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PCO
MCID: PLY011
MIFTS: 56

Polycystic Ovary Syndrome (PCO)

Categories: Endocrine diseases, Rare diseases, Reproductive diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Polycystic Ovary Syndrome

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MalaCards integrated aliases for Polycystic Ovary Syndrome:

Name: Polycystic Ovary Syndrome 12 74 25 36 54 42 43 15 17 71
Polycystic Ovarian Syndrome 74 52 25 15 32
Polycystic Ovaries 12 29 54
Pcos 12 52 25
Polycystic Ovarian Disease 12 25
Stein-Leventhal Syndrome 12 25
Sclerocystic Ovaries 25 71
Multicystic Ovaries 12 25
Polycystic Ovary Syndrome, Susceptibility to 6
Sclerocystic Ovarian Degeneration 25
Sclerocystic Ovary Syndrome 25
Cystic Disease of Ovaries 25
Cystic Disease of Ovary 25
Stein-Leventhal Synd. 12
Polycystic Ovary 12
Pcod 25
Pco 25

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Endocrine diseases Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:11612
KEGG 36 H01739
ICD9CM 34 256.4
MeSH 43 D011085
NCIt 49 C26862
SNOMED-CT 67 237055002
ICD10 32 E28.2
UMLS 71 C0032460 C1136382
Sources

Summaries for Polycystic Ovary Syndrome

About this section
Genetics Home Reference : 25 Polycystic ovary syndrome is a condition that affects women in their child-bearing years and alters the levels of multiple hormones, resulting in problems affecting many body systems. Most women with polycystic ovary syndrome produce excess male sex hormones (androgens), a condition called hyperandrogenism. Having too much of these hormones typically leads to excessive body hair growth (hirsutism), acne, and male pattern baldness. Hyperandrogenism and abnormal levels of other sex hormones prevent normal release of egg cells from the ovaries (ovulation) and regular menstrual periods, leading to difficulty conceiving a child (subfertility) or a complete inability to conceive (infertility). For those who achieve pregnancy, there is an increased risk of complications and pregnancy loss. Due to irregular and infrequent menstruation and hormone abnormalities, affected women have an increased risk of cancer of the uterine lining (endometrial cancer). In polycystic ovary syndrome, one or both ovaries can contain multiple small, immature ovarian follicles that can appear as cysts on medical imaging. Normally, ovarian follicles contain egg cells, which are released during ovulation. In polycystic ovary syndrome, abnormal hormone levels prevent follicles from growing and maturing to release egg cells. Instead, these immature follicles accumulate in the ovaries. Affected women can have 12 or more of these follicles. The number of these follicles usually decreases with age. About half of all women with polycystic ovary syndrome are overweight or obese and are at increased risk of a fatty liver. Additionally, many women with polycystic ovary syndrome have elevated levels of insulin, which is a hormone that helps control blood sugar levels. By age 40, about 10 percent of overweight women with polycystic ovary syndrome develop abnormally high blood sugar levels (type 2 diabetes), and up to 35 percent develop prediabetes (higher-than-normal blood sugar levels that do not reach the cutoff for diabetes). Obesity and increased insulin levels (hyperinsulinemia) further increase the production of androgens in polycystic ovary syndrome. Women with polycystic ovary syndrome are also at increased risk for developing metabolic syndrome, which is a group of conditions that include high blood pressure (hypertension), increased belly fat, high levels of unhealthy fats and low levels of healthy fats in the blood, and high blood sugar levels. About 20 percent of affected adults experience pauses in breathing during sleep (sleep apnea). Women with polycystic ovary syndrome are more likely than women in the general popluation to have mood disorders such as depression.

MalaCards based summary : Polycystic Ovary Syndrome, also known as polycystic ovarian syndrome, is related to ovarian cyst and alopecia, androgenetic, 1, and has symptoms including pelvic pain An important gene associated with Polycystic Ovary Syndrome is ENSG00000230704 (), and among its related pathways/superpathways are Glucose / Energy Metabolism and HIF-1 signaling pathway. The drugs Levonorgestrel and Lamotrigine have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and endothelial, and related phenotypes are endocrine/exocrine gland and liver/biliary system

Disease Ontology : 12 An ovarian dysfunction that is characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight.

NIH Rare Diseases : 52 Polycystic ovarian syndrome (PCOS) is a health problem that can affect a woman's menstrual cycle, ability to have children, hormones , heart, blood vessels, and appearance. Women with this condition typically have high levels of hormones called androgens , missed or irregular periods, and many small cysts in their ovaries. The cause of PCOS is unknown, but probably involves a combination of genetic and environmental factors . Treatment for PCOS may involve birth control pills and medications for diabetes and infertility. Medicines called anti-androgens are also used to speed the growth of hair and clear acne.

MedlinePlus : 42 Polycystic ovary syndrome (PCOS) happens when a woman's ovaries or adrenal glands produce more male hormones than normal. PCOS causes cysts (fluid-filled sacs) to grow on the ovaries. Symptoms include Irregular menstrual periods Infertility Pelvic pain Excess hair growth on the face, chest, stomach, or thighs Weight gain Acne or oily skin Patches of thickened skin Women with PCOS are at higher risk of diabetes, metabolic syndrome, heart disease, and high blood pressure. PCOS is more common in women who have obesity or have a mother or sister with PCOS. To diagnose PCOS, your health care provider may do a physical exam, pelvic exam, blood tests, and an ultrasound. There is no cure, but diet, exercise, and medicines can help control the symptoms. Birth control pills help women have normal periods, reduce male hormone levels, and clear acne. Treatments for infertility caused by PCOS may include medicines, surgery, and in vitro fertilization (IVF). NIH: National Institute of Child Health and Human Development

KEGG : 36 Polycystic ovary syndrome (PCOS) is a common heterogeneous endocrine disorder characterized by elevated androgen levels, menstrual irregularities, and/or small cysts on one or both ovaries. Clinical manifestations include oligomenorrhea or amenorrhea, hirsutism, and frequently infertility. Clinical signs of PCOS include elevated luteinizing hormone (LH) and gonadotropin-releasing hormone (GnRH) levels, whereas follicle-stimulating hormone (FSH) levels are muted or unchanged. As a result of the increase in GnRH, stimulation of the ovarian theca cells, in turn, produces more androgens. Risk factors for PCOS in adults includes insulin resistance (IR), type 2 diabetes, obesity, and cardiovascular disease. PCOS can be described as an oligogenic disorder in which the interaction of a number of genetic and environmental factors determine the heterogeneous, clinical, and biochemical phenotype. Management of clinical manifestations of PCOS includes oral contraceptives for menstrual irregularities and hirsutism. Treatment options for infertility include clomiphene, laparoscopic ovarian drilling, gonadotropins, and assisted reproductive technology.

Wikipedia : 74 Polycystic ovary syndrome (PCOS) is a set of symptoms due to elevated androgens (male hormones) in... more...

Sources

Related Diseases for Polycystic Ovary Syndrome

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Diseases in the Polycystic Ovary Syndrome family:

Polycystic Ovary Syndrome 1

Diseases related to Polycystic Ovary Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 601)
# Related Disease Score Top Affiliating Genes
1 ovarian cyst 33.3 PRL GNRH1 CYP19A1
2 alopecia, androgenetic, 1 33.2 SHBG CYP21A2 CYP19A1
3 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 32.9 INSR INS IGF1
4 cytochrome p450 oxidoreductase deficiency 32.6 CYP21A2 CYP17A1
5 hyperinsulinism 32.5 SHBG INSR INS IGF1 GNRH1
6 ovarian disease 32.4 SHBG PRL INSR INS IGF1 GNRH1
7 infertility 32.4 SHBG PRL GNRH1 GDF9 CYP19A1
8 ovarian hyperstimulation syndrome 32.3 SHBG INS GNRH1 CYP19A1
9 lipid metabolism disorder 32.2 SHBG INSR INS CYP21A2
10 gestational diabetes 32.2 SHBG INSR INS IGF1 CAPN10
11 glucose intolerance 32.2 SHBG INSR INS IGF1 CAPN10
12 anovulation 32.0 SHBG PRL INS IGF1 GNRH1 GDF9
13 acanthosis nigricans 32.0 SHBG PRL INSR INS IGF1
14 hyperprolactinemia 31.7 SHBG PRL INS IGF1 GNRH1
15 insulin-like growth factor i 31.7 SHBG PRL INSR INS IGF1
16 amenorrhea 31.7 SHBG PRL INS IGF1 GNRH1 GDF9
17 hyperandrogenism 31.6 SHBG PRL INSR INS IGF1 GNRH1
18 hypothyroidism 31.6 SHBG PRL INS IGF1 GNRH1
19 androgenic alopecia 31.5 SHBG PRL INS IGF1 CYP19A1
20 sexual disorder 31.5 SHBG PRL INS IGF1 GNRH1
21 galactorrhea 31.4 PRL IGF1
22 hypoglycemia 31.4 PRL INSR INS IGF1
23 sleep disorder 31.3 PRL INS IGF1
24 estrogen excess 31.2 SHBG PRL GNRH1 CYP19A1
25 precocious puberty 31.1 GNRH1 CYP21A2 CYP19A1
26 acromegaly 31.1 SHBG PRL INS IGF1 GNRH1
27 central precocious puberty 31.1 IGF1 GNRH1
28 bone resorption disease 31.1 INS IGF1 CYP19A1
29 fetal macrosomia 31.1 INSR INS IGF1
30 male infertility 31.1 SHBG GNRH1 CYP21A2 CYP19A1
31 goiter 31.0 SHBG PRL INS IGF1
32 pituitary gland disease 31.0 PRL INS IGF1 GNRH1
33 body mass index quantitative trait locus 11 31.0 SHBG PRL INSR INS IGF1 FST
34 pseudohermaphroditism 31.0 CYP21A2 CYP19A1 CYP17A1
35 anorexia nervosa 30.9 SHBG PRL INS IGF1
36 endometrial cancer 30.9 SHBG INS IGF1 GNRH1 GAS5 CYP19A1
37 hypogonadism 30.9 SHBG PRL INS IGF1 GNRH1 CYP19A1
38 lipoid congenital adrenal hyperplasia 30.9 SHBG PRL INS GNRH1 CYP21A2 CYP19A1
39 aromatase deficiency 30.8 INS GNRH1 CYP19A1
40 thyroid gland disease 30.8 SHBG PRL INS IGF1
41 premature menopause 30.8 GNRH1 GDF9 CYP19A1
42 diabetes mellitus, noninsulin-dependent 30.8 SHBG INSR INS IGF1 GAS5 FST
43 hyperthyroidism 30.8 SHBG PRL INS IGF1
44 leiomyoma 30.8 GNRH1 CYP19A1 CYP17A1
45 breast disease 30.8 SHBG PRL IGF1 CYP19A1
46 donohue syndrome 30.6 INSR INS IGF1
47 premenstrual tension 30.6 SHBG GNRH1
48 psychosexual disorder 30.6 SHBG PRL
49 empty sella syndrome 30.5 PRL INS IGF1 GNRH1
50 primary hyperparathyroidism 30.5 PRL INS IGF1

Graphical network of the top 20 diseases related to Polycystic Ovary Syndrome:



Diseases related to Polycystic Ovary Syndrome
Sources

Symptoms & Phenotypes for Polycystic Ovary Syndrome

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UMLS symptoms related to Polycystic Ovary Syndrome:


pelvic pain

MGI Mouse Phenotypes related to Polycystic Ovary Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.85 CAPN10 CYP11A1 CYP19A1 FST GDF9 GNRH1
2 liver/biliary system MP:0005370 9.5 CAPN10 CYP11A1 CYP19A1 GNRH1 INS INSR
3 reproductive system MP:0005389 9.32 CYP11A1 CYP17A1 CYP19A1 FST GDF9 GNRH1
Sources

Drugs & Therapeutics for Polycystic Ovary Syndrome

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Drugs for Polycystic Ovary Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 336)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levonorgestrel Approved, Investigational Phase 4 797-63-7, 17489-40-6 13109
2
Lamotrigine Approved, Investigational Phase 4 84057-84-1 3878
3
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
4
Cetrorelix Approved, Investigational Phase 4 120287-85-6 16129715 25074887
5
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
6
Moxonidine Approved, Investigational Phase 4 75438-57-2 4810
7
Simvastatin Approved Phase 4 79902-63-9 54454
8
Alogliptin Approved Phase 4 850649-61-5 11450633
9
Citalopram Approved Phase 4 59729-33-8 2771
10
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
11
Hydroxocobalamin Approved Phase 4 13422-51-0 15589840 11953898
12
Isotretinoin Approved Phase 4 4759-48-2 5282379 5538
13
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
14
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
15
Tamoxifen Approved Phase 4 10540-29-1 2733526
16
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
17
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
18
Leuprolide Approved, Investigational Phase 4 53714-56-0 657181 3911
19
Liraglutide Approved Phase 4 204656-20-2 44147092
20
Lactitol Approved, Investigational Phase 4 585-88-6, 585-86-4 493591
21
Drospirenone Approved Phase 4 67392-87-4 68873
22
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
23
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
24
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
25 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
26
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
27
Zinc Approved, Investigational Phase 4 7440-66-6 32051
28
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
29
Letrozole Approved, Investigational Phase 4 112809-51-5 3902
30
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
31
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
32
Orlistat Approved, Investigational Phase 4 96829-58-2 3034010
33
Iron Approved, Experimental Phase 4 15438-31-0, 7439-89-6 27284 23925
34
Testosterone Approved, Experimental, Investigational Phase 4 58-22-0, 481-30-1 10204 6013
35
leucovorin Approved Phase 4 58-05-9 6006 143
36
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
37
Inulin Approved, Investigational, Nutraceutical Phase 4 9005-80-5 24763
38
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
39
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
40
Calcifediol Approved, Nutraceutical Phase 4 19356-17-3 5283731 6433735
41
Manganese Approved, Nutraceutical Phase 4 7439-96-5 27854
42
Cysteine Approved, Nutraceutical Phase 4 52-90-4 5862
43
Coenzyme Q10 Approved, Investigational, Nutraceutical Phase 4 303-98-0 5281915
44
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
45
Cobalamin Experimental Phase 4 13408-78-1 6857388
46
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
47
2,4-thiazolidinedione Investigational Phase 4 2295-31-0
48 Diuretics, Potassium Sparing Phase 4
49 Hemostatics Phase 4
50 carnitine Phase 4

Interventional clinical trials:

(show top 50) (show all 815)
# Name Status NCT ID Phase Drugs
1 Endometrial Thickness And Subendometrial Vascularity In Anovulatory Polycystic Ovarian Syndrome Patients Treated by Metformin Unknown status NCT03486626 Phase 4 Metformin
2 Endometrial Scratching at Time of Laproscopic Ovarian Drilling in Women With Anovulatory Infertility Due to Polycystic Ovarian Syndrome (PCOS): Randomized Controlled Trial. Unknown status NCT02140398 Phase 4
3 Randomized Controlled Trial Comparing the Effect of GnRH Agonist and Antagonist Ovarian Stimulation Protocols in PCOS Patients Unknown status NCT00417144 Phase 4 Arvekap 0.1mg (Triptorelin, Ipsen, France);Ganirelix 0.25mg (Orgalutran, Organon, The Netherlands)
4 Therapeutic Monitoring of Metformin in Women With Polycystic Ovary Syndrome Unknown status NCT01366391 Phase 4 Metformin
5 The Effect of Weight Loss With Orlistat or Sibutramine Administration , Hypocaloric Diet and Physical Exercise , on AMH Levels, in Women With Polycystic Ovary Syndrome Unknown status NCT01475019 Phase 4 Orlistat;Sibutramine
6 PERCING : Ovarian Drilling Versus Ovarian Stimulation + Intra Uterine Insemination (IUI) + Metformin in the PCOS (PolyCystic Ovaries Syndrome) Treatment Unknown status NCT00378729 Phase 4 Metformin and FSHr
7 Prospective, Randomized, Double - Blind Placebo Controlled Trial of Simvastatin and Resveratrol Therapy on Clinical, Endocrinological, Biochemical and Endothelial Dysfunction Parameters in Women With Polycystic Ovary Syndrome. Unknown status NCT02766803 Phase 4 Simvastatin and micronized trans-resveratrol
8 Comparison of Three Different Strategies for Treating Infertility in Anovulatory Women With Polycystic Ovary Syndrome: a Multicentre Randomized Controlled Clinical Trial Unknown status NCT00461643 Phase 4 Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
9 Effects of Different Therapies on Surrogate Markers of Cardiovascular Risk in Women With Polycystic Ovary Syndrome (PCOS) Unknown status NCT01798875 Phase 4 oral metformin;oral contraceptive
10 The Effect of Diane-35 Pretreatment on Endocrine and Clinical Profile for Patients With Polycystic Ovary Syndrome Undergoing In-vitro Fertilization Unknown status NCT01752270 Phase 4 Diane-35 pretreatment;Diane-35 pretreatment
11 Corifollitropin Alfa in Combination With Elective Cryopreservation of All Embryos After GnRH Agonist Triggering of Final Oocyte Maturation in PCOS Patients- a Prospective, Observational Proof-of -Concept Study Unknown status NCT02215135 Phase 4 Corifollitropin alfa
12 Prospective, Randomized, Double - Blind, Placebo Controlled Trial of Dietary Modification in Conjunction With Probiotic Therapy on Clinical and Endocrinological Parameters as Well as Body Composition in Women With Polycystic Ovary Syndrome Unknown status NCT03325023 Phase 4
13 Efficacy of Long- Versus Short-term Metformin Protocol in Infertile Anovulatory PCOS Patients Unknown status NCT00501904 Phase 4 Metformin
14 A Comparison Study of a Novel Stimulation Protocol With Metformin in Step-down Regimen and the Conventional Low Dose Step-up Protocol in Patients With Polycystic Ovary Syndrome Undergoing in Vitro Fertilization Unknown status NCT01438190 Phase 4 Metformin, gonadotropins in step-down regimen;Placebo, gonadotropins in step-up regimen
15 The Changes of Hemocoagulation and Lipoperoxidation in Women Using Combined Oral Contraceptives With Antiandrogenic Activity, Correction by Antioxidants Unknown status NCT02027337 Phase 4 20 mcg ethinylestradiol /3 mg drospirenone;20 mcg ethinylestradiol/3 mg drospirenone and Selmevit;30 mcg ethinylestradiol/3 mg drospirenone;30 mcg ethinylestradiol/3 mg drospirenone and Selmevit;35 mcg ethinylestradiol/2 mg cyproterone;35 mcg ethinylestradiol/2 mg cyproterone and Selmevit
16 Metformin Treatment for Preventing Gestational Diabetes in High-risk Patients Unknown status NCT00883259 Phase 4 Metformin
17 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in PCOS Patients. Unknown status NCT01246310 Phase 4
18 The Effects of Contraceptive Pill and Hormonal Vaginal Ring on Hormonal, Inflammatory and Metabolic Parameters in Women of Reproductive Age With Polycystic Ovary Syndrome (PCOS). Unknown status NCT01588873 Phase 4 oc:E-E-desogestrel/vaginal ring:E-E -ethonogestrel
19 Metformin for the Treatment of Unexplained Oligozspermia and Azoospermia Unknown status NCT01529177 Phase 4 Metformin / clomid / hCG;Clomiphene citrate / hCG
20 Hormone Profiles in Adults Treated With Valproate vs. Lamotrigine Monotherapy for Newly Diagnosed Epilepsy: A Prospective Randomised Study Unknown status NCT00137709 Phase 4 Sodium valproate;Lamotrigine
21 Prospective Randomized Trial on GnRH Agonist Triggering Versus hCG Triggering in IVF Stimulation in PCOS Patients Unknown status NCT01683513 Phase 4 GnRh agonist +1500E hCG
22 Adding L-carnitine in Clomiphene Resistant Pco Improves the Quality of Ovulation and the Pregnancy Outcome,a Randomized Clinical Trial Unknown status NCT01665547 Phase 4 l-carnitine
23 Levonorgestrel-releasing Intrauterine Device Effects on Hemostatic and Arterial Function of Obese Women Unknown status NCT01320917 Phase 4
24 Phase 4 Study of Effectiveness of Metformin in Patients With Unexplained Recurrent Miscarriages Unknown status NCT01718340 Phase 4 Metformin
25 Administration of Single High Dose Letrozole for Ovulation Induction - A Randomized Controlled Trial Unknown status NCT02703649 Phase 4 Letrozole
26 Follicular Fluid, Serum Endocrine Profile Following Stimulation With Recombinant Gonadotropins or Highly Purified Human Menopausal Gonadotropin During GnRH-antagonist Protocol Unknown status NCT02992808 Phase 4 recombinant gonadotropins;HP-HMG
27 Ovarian Stimulation and Intrauterine Insemination in Women With Polycystic Ovarian Syndrome Completed NCT01675843 Phase 4
28 Phytoestrogens as an Alternative to Estradiol in Reversing the Antiestrogenic Effect of Clomid on Endometrium in Ovulation Induction in Cases of Polycystic Ovarian Syndrome Completed NCT02352597 Phase 4 phytoestrogen;estradiol valerate;clomiphene citrate
29 Polycystic Ovary Syndrome - Targeting the Sympathetic Nervous System to Improve Outcomes Completed NCT01504321 Phase 4 Moxonidine;Placebo
30 Multi-Centre Randomised Controlled Trial of the Effectiveness of Metformin and Clomiphene Citrate for Treating Anovulatory Infertility in Women With Polycystic Ovary Syndrome Completed NCT00795808 Phase 4 Metformin;Placebo;Metformin + Clomiphene;Metformin;Clomiphene
31 Short-term Liraglutide Treatment in Obese Women With Polycystic Ovary Syndrome Completed NCT01899430 Phase 4 liraglutide;metformin
32 Effects of Structured Exercise Program Versus Hypocaloric Hyperproteic Diet on the Reproductive Function in Obese Anovulatory Infertile Patients With Polycystic Ovary Syndrome: a 24-Week Prospective Study. Completed NCT00473538 Phase 4
33 Comparison of Alogliptin Versus Alogliptin and Pioglitazone on Insulin Resistance of Metformin Treated Women With PCOS Completed NCT02683226 Phase 4 Vipdomet;Incresync
34 Therapeutic Effect of Vitamin D3 Supplementation to Clomiphene Citrate Resistant Polycystic Ovary Syndrome Women Completed NCT04010942 Phase 4 Vit D;Metformin;Clomiphene
35 Role of Melatonin Supplementation in Follicular Fluid of in Vitro Fertilization (IVF) Patients With Polycystic Ovarian Syndrome Completed NCT01540747 Phase 4
36 The Cardiovascular Risk Profile Associated With The Polycystic Ovary Syndrome And With Ovulatory Hyperandrogenism, And Its Changes During Treatment With Metformin Or Oral Contraceptives Completed NCT00428311 Phase 4 Metformin;Ethynyl-estradiol plus cyproterone acetate
37 Combined Treatment With PDE-4 Inhibitor Roflumilast and Metformin Leads to Significant Weight Loss in Obese Women With Polycystic Ovary Syndrome Completed NCT02037672 Phase 4 metformin;metformin and roflumilast
38 Effects of Metformin Plus Simvastatin on Polycystic Ovarian Syndrome (PCOS): A Prospective, Randomized, Double-Blind, Placebo-Controlled Study Completed NCT01021579 Phase 4 Metformin plus Placebo;Metfomin plus Simvastatin
39 Low Dose Liraglutide and Metformin vs. High Dose Liraglutide Alone in Treatment of Obesity Completed NCT02909933 Phase 4 liraglutide;metformin and liraglutide
40 A Randomised, Double-blind, Placebo-controlled Study of the Effect of Liraglutide in Polycystic Ovary Syndrome on Risk Markers of Vascular Thrombosis. Completed NCT02073929 Phase 4 Liraglutide for 26 weeks;placebo
41 Liraglutide as Add on Therapy on Metformin in Women With Polycystic Ovary Syndrome Completed NCT02483299 Phase 4 Metformin;Glucophage tablets and Victoza
42 Inkretineffekten Hos Patienter Med Polycystisk Ovariesyndrom før og Efter Behandling af Insulinresistens (Incretin Effect in Patients With Polycystic Ovary Syndrome Before and After Treatment of Insulin Resistance) Completed NCT01892254 Phase 4 Metformin;Placebo
43 A Clinical Trial to Measure the Effect of DHA-enriched Fish Oils on Blood Pressure, Heart Rate Variability and Liver Fat Content in the Polycystic Ovary Syndrome Completed NCT00620529 Phase 4
44 The Effect of Metformin on Serum Insulin, Androgens and AMH in PCOS Patients Completed NCT02568488 Phase 4 Metformin
45 The Effect of Cipralex in Polycystic Ovary Syndrome Completed NCT01961180 Phase 4 Cipralex;Placebo
46 A Multi-Center, Randomized, Open-Label Evaluation of MENOPUR® Versus FOLLISTIM® in Polycystic Ovarian Syndrome (PCOS) Patients Completed NCT00805935 Phase 4 Menotropin;Progesterone vaginal insert;Follitropin beta;Progesterone in oil;leuprolide acetate
47 Short-term Combined Treatment With Liraglutide and Metformin Leads to Significant Weight Loss in Obese Women With Polycystic Ovary Syndrome and Previous Poor Response to Metformin Completed NCT01911468 Phase 4 metformin;liraglutide;metformin and liraglutide
48 Short-term Treatment With PDE-4 Inhibitor Roflumilast or GLP-1 Agonist Liraglutide or Metformin in Treatment Naive Obese Women With Polycystic Ovary Syndrome Completed NCT02187250 Phase 4 metformin;liraglutide;roflumilast
49 Double Blind Cross-over Randomized Controlled Trial Comparing Letrozole Versus Clomifene Citrate for Ovulation Induction in Women With Polycystic Ovarian Syndrome Completed NCT00478504 Phase 4 Letrozole;Clomifene citrate
50 Metformin vs. Acarbose Treatment in Infertile Overweight Women With PCOS: A Prospective Randomized Clinical Trial Completed NCT01279512 Phase 4 Metformin;Acarbose

Search NIH Clinical Center for Polycystic Ovary Syndrome

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Urofollitropin

Cochrane evidence based reviews: polycystic ovary syndrome

Sources

Genetic Tests for Polycystic Ovary Syndrome

About this section

Genetic tests related to Polycystic Ovary Syndrome:

# Genetic test Affiliating Genes
1 Polycystic Ovaries 29
Sources

Anatomical Context for Polycystic Ovary Syndrome

About this section

MalaCards organs/tissues related to Polycystic Ovary Syndrome:

40
Ovary, Liver, Endothelial, Heart, Testes, Pituitary, Skin
Sources

Publications for Polycystic Ovary Syndrome

About this section

Articles related to Polycystic Ovary Syndrome:

(show top 50) (show all 14644)
# Title Authors PMID Year
1
Specific CAPN10 gene haplotypes influence the clinical profile of polycystic ovary patients. 54 61 6
14602801 2003
2
Comment: CAPN10 alleles are associated with polycystic ovary syndrome. 54 61 6
12161543 2002
3
Psychological well-being and personality in relation to weight loss following behavioral modification intervention in obese women with polycystic ovary syndrome: a randomized controlled trial. 61 42
32503005 2020
4
Clinical effects of Shou-Wu Jiang-Qi Decoction combined acupuncture on the treatment of Polycystic Ovarian Syndrome with kidney deficiency, phlegm and blood stasisness: Study protocol clinical trial (SPIRIT Compliant). 42 61
32195930 2020
5
Letrozole and human menopausal gonadotropin for ovulation induction in clomiphene resistance polycystic ovary syndrome patients: A randomized controlled study. 42 61
31977842 2020
6
Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility. 6
14574648 2003
7
Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom. 6
11481585 2001
8
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. 6
11017071 2000
9
Genetic variations of follicle stimulating hormone receptor are associated with polycystic ovary syndrome. 61 54
20514429 2010
10
C-reactive protein and homocysteine levels are associated with abnormal heart rate recovery in women with polycystic ovary syndrome. 54 61
19362308 2010
11
FSH receptor, KL1/2, P450, and PAPP genes in granulosa-lutein cells from in vitro fertilization patients show a different expression pattern depending on the infertility diagnosis. 61 54
19342032 2010
12
Expression of growth differentiation factor-9 and bone morphogenetic protein-15 in oocytes and cumulus granulosa cells of patients with polycystic ovary syndrome. 54 61
19376510 2010
13
CYP19 gene: a genetic modifier of polycystic ovary syndrome phenotype. 61 54
19324338 2010
14
No association of the G972S polymorphism of the insulin receptor substrate-1 gene with polycystic ovary syndrome in lean PCOS women with biochemical hyperandrogenemia. 54 61
20012307 2010
15
Insulin resistance and overweight-obese women with polycystic ovary syndrome. 54 61
19903118 2010
16
Identification of the G994T polymorphism in exon 9 of plasma platelet-activating factor acetylhydrolase gene as a risk factor for polycystic ovary syndrome. 61 54
20185515 2010
17
Serum soluble glycoprotein 130 concentration is inversely related to insulin sensitivity in women with polycystic ovary syndrome. 54 61
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18
Decreased active, total and altered active to total ghrelin ratio in normal weight women with the more severe form of polycystic ovary syndrome. 61 54
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19
The effect of serum and intrafollicular insulin resistance parameters and homocysteine levels of nonobese, nonhyperandrogenemic polycystic ovary syndrome patients on in vitro fertilization outcome. 54 61
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20
Increased follistatin levels after oral contraceptive treatment in obese and non-obese women with polycystic ovary syndrome. 54 61
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21
Serum resistin and adiponectin levels in young non-obese women with polycystic ovary syndrome. 61 54
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22
[Polymorphism of CYP11A1 gene in Chinese patients with polycystic ovarian syndrome]. 54 61
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23
High-molecular-weight adiponectin is selectively reduced in women with polycystic ovary syndrome independent of body mass index and severity of insulin resistance. 54 61
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24
Effect of rimonabant and metformin on glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 in obese women with polycystic ovary syndrome. 61 54
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Flexible GnRH antagonist protocol versus GnRH agonist long protocol in patients with polycystic ovary syndrome treated for IVF: a prospective randomised controlled trial (RCT). 54 61
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26
Hepatic steatosis in young lean insulin resistant women with polycystic ovary syndrome. 54 61
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27
Regulation of adiponectin secretion by adipocytes in the polycystic ovary syndrome: role of tumor necrosis factor-{alpha}. 61 54
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28
Polymorphisms of the insulin receptor and the insulin receptor substrates genes in polycystic ovary syndrome: a Mendelian randomization meta-analysis. 54 61
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29
Metformin versus laparoscopic ovarian drilling in clomiphene- and insulin-resistant women with polycystic ovary syndrome. 54 61
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30
Effect of metformin on serum visfatin levels in patients with polycystic ovary syndrome. 61 54
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Serum retinol-binding protein 4 levels in nonobese women with polycystic ovary syndrome. 54 61
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32
Decreased adiponectin levels in polycystic ovary syndrome, independent of body mass index. 61 54
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[Activity and distribution of plasma platelet-activating factor acetylhydrolase in polycystic ovary syndrome patients with insulin resistance]. 61 54
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34
Association of insulin resistance with anti-Mullerian hormone levels in women without polycystic ovary syndrome (PCOS). 61 54
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Adiponectin and resistin concentrations after glucose load in adolescents with polycystic ovary syndrome. 61 54
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36
Unilateral ovarian enlargement in adolescents with polycystic ovary syndrome: a variant of bilateral disease. 54 61
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37
Endothelial function and insulin resistance in polycystic ovary syndrome: the effects of medical therapy. 54 61
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38
The relationship between follistatin and chronic low-grade inflammation in women with polycystic ovary syndrome. 61 54
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Association between CYP19 gene SNP rs2414096 polymorphism and polycystic ovary syndrome in Chinese women. 54 61
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Adiponectin levels reflect the different phenotypes of polycystic ovary syndrome: study in normal weight, normoinsulinemic patients. 61 54
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41
Response of IGF and IL-6 to ovarian stimulation in PCOS and normal women. 54 61
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42
Altered distribution of plasma platelet-activating factor acetylhydrolase between high-density lipoprotein and low-density lipoprotein in patients with polycystic ovary syndrome. 54 61
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Central-to-peripheral fat ratio, but not peripheral body fat, is related to insulin resistance and androgen markers in polycystic ovary syndrome. 54 61
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44
Adiponectin levels in adolescent girls with polycystic ovary syndrome (PCOS). 54 61
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45
Effects of polymorphisms of the sex hormone-binding globulin (SHBG) gene on free estradiol and bone mineral density. 54 61
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[Increased risk of early pregnancy loss and lower live birth rate with GNRH antagonist vs. long GNRH agonist protocol in PCOS women undergoing controlled ovarian hyperstimulation]. 61 54
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[The activity of platelet activating factor acetylhydrolase and its metabolic profile in patients with polycystic ovary syndrome]. 54 61
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Body fat and insulin resistance independently predict increased serum C-reactive protein in hyperandrogenic women with polycystic ovary syndrome. 61 54
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Association of single nucleotide polymorphisms in adiponectin and its receptor genes with polycystic ovary syndrome. 61 54
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50
Thyroid-stimulating hormone is associated with insulin resistance independently of body mass index and age in women with polycystic ovary syndrome. 61 54
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Variations for Polycystic Ovary Syndrome

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ClinVar genetic disease variations for Polycystic Ovary Syndrome:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CAPN10 NM_023083.4(CAPN10):c.471-187T>CSNV risk factor 5096 rs2975760 2:241531163-241531163 2:240591746-240591746
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Expression for Polycystic Ovary Syndrome

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Search GEO for disease gene expression data for Polycystic Ovary Syndrome.
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Pathways for Polycystic Ovary Syndrome

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Pathways related to Polycystic Ovary Syndrome according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Glucose / Energy Metabolism 4
12.14 INSR INS CYP19A1 CYP17A1 CYP11A1
2
HIF-1 signaling pathway 36
11.67 INSR INS IGF1
3
G-protein signaling_RhoA regulation pathway 22
11.47 INSR IGF1 GNRH1 GDF9
4
AGE/RAGE pathway 1
11.43 MSR1 INSR INS
5
Metabolism of steroid hormones 65
Show member pathways
 11.4 CYP21A2 CYP19A1 CYP17A1 CYP11A1
6
Signaling events mediated by PTP1B 1
11.28 PRL INSR INS
7
Differentiation Pathway 1
11.23 INS IGF1 FST
8
Steroid hormone biosynthesis 36
Show member pathways
 11.08 CYP21A2 CYP19A1 CYP17A1 CYP11A1
9
Aldosterone-regulated sodium reabsorption 36
11.07 INSR INS IGF1
10
Ovarian steroidogenesis 36
10.81 INSR INS IGF1 CYP19A1 CYP17A1 CYP11A1
11
Nongenotropic Androgen signaling 1
10.75 SHBG GNRH1
Sources

GO Terms for Polycystic Ovary Syndrome

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Cellular components related to Polycystic Ovary Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 8.96 PRL INS
2 organelle membrane GO:0031090 8.8 CYP21A2 CYP19A1 CYP17A1

Biological processes related to Polycystic Ovary Syndrome according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.92 PRL INSR INS IGF1 GDF9
2 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.67 INSR INS IGF1
3 activation of protein kinase B activity GO:0032148 9.61 INSR INS IGF1
4 positive regulation of mitotic nuclear division GO:0045840 9.58 INSR INS IGF1
5 amyloid-beta clearance GO:0097242 9.54 MSR1 INSR
6 sterol metabolic process GO:0016125 9.54 CYP21A2 CYP19A1 CYP11A1
7 male sex determination GO:0030238 9.51 INSR GNRH1
8 positive regulation of glycolytic process GO:0045821 9.5 INSR INS IGF1
9 neuron projection maintenance GO:1990535 9.48 INSR INS
10 positive regulation of respiratory burst GO:0060267 9.46 INSR INS
11 steroid biosynthetic process GO:0006694 9.46 CYP21A2 CYP19A1 CYP17A1 CYP11A1
12 positive regulation of glycogen biosynthetic process GO:0045725 9.43 INSR INS IGF1
13 glucocorticoid biosynthetic process GO:0006704 9.13 CYP21A2 CYP17A1 CYP11A1
14 positive regulation of glucose import GO:0046326 8.92 INSR INS IGF1 CAPN10

Molecular functions related to Polycystic Ovary Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.67 CYP21A2 CYP19A1 CYP17A1 CYP11A1
2 iron ion binding GO:0005506 9.62 CYP21A2 CYP19A1 CYP17A1 CYP11A1
3 hormone activity GO:0005179 9.56 PRL INS IGF1 GNRH1
4 monooxygenase activity GO:0004497 9.46 CYP21A2 CYP19A1 CYP17A1 CYP11A1
5 cargo receptor activity GO:0038024 9.4 MSR1 INSR
6 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.26 CYP21A2 CYP19A1 CYP17A1 CYP11A1
7 insulin-like growth factor receptor binding GO:0005159 8.8 INSR INS IGF1
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Sources for Polycystic Ovary Syndrome

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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