MCID: PLY105
MIFTS: 30

Polycystic Ovary Syndrome 1

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Polycystic Ovary Syndrome 1

MalaCards integrated aliases for Polycystic Ovary Syndrome 1:

Name: Polycystic Ovary Syndrome 1 57 13
Polycystic Ovary Syndrome 73
Stein-Leventhal Syndrome 57
Hyperandrogenemia 57
Pco1; Pco 57
Pcos1 57
Pco1 57
Pcos 57
Pco 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant
probably heterogeneous


HPO:

32
polycystic ovary syndrome 1:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 184700
MedGen 42 C0032460

Summaries for Polycystic Ovary Syndrome 1

MalaCards based summary : Polycystic Ovary Syndrome 1, also known as polycystic ovary syndrome, is related to classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency and polycystic ovary syndrome, and has symptoms including pelvic pain An important gene associated with Polycystic Ovary Syndrome 1 is PCOS1 (Polycystic Ovary Syndrome 1). The drugs Metformin and Cyproterone Acetate have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and brain, and related phenotypes are obesity and abnormality of metabolism/homeostasis

Description from OMIM: 184700

Related Diseases for Polycystic Ovary Syndrome 1

Diseases in the Polycystic Ovary Syndrome family:

Polycystic Ovary Syndrome 1

Diseases related to Polycystic Ovary Syndrome 1 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 11.0
2 polycystic ovary syndrome 9.8

Symptoms & Phenotypes for Polycystic Ovary Syndrome 1

Symptoms via clinical synopsis from OMIM:

57
Growth:
obesity

Hair:
hirsutism

Misc:
response to bilateral wedge resection of the ovaries
increased frequency of early baldness or excessive hairiness in male first-degree relatives

GU:
enlarged polycystic ovaries
amenorrhea
oligomenorrhea

Endocrine:
no virilization

Lab:
normal 24-hr urinary ketosteroids
elevated dehydroepiandrosteronesulfate
increased 5-alpha-reductase activity in the liver and skin
elevated androstanedione and/or testosterone and luteinizing hormone
low estradiol and follicle-stimulating hormone levels
more

Clinical features from OMIM:

184700

Human phenotypes related to Polycystic Ovary Syndrome 1:

32 (show all 6)
# Description HPO Frequency HPO Source Accession
1 obesity 32 HP:0001513
2 abnormality of metabolism/homeostasis 32 HP:0001939
3 enlarged polycystic ovaries 32 HP:0008675
4 amenorrhea 32 HP:0000141
5 hirsutism 32 HP:0001007
6 oligomenorrhea 32 HP:0000876

UMLS symptoms related to Polycystic Ovary Syndrome 1:


pelvic pain

Drugs & Therapeutics for Polycystic Ovary Syndrome 1

Drugs for Polycystic Ovary Syndrome 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 344)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 657-24-9 14219 4091
2
Cyproterone Acetate Approved, Investigational Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable 427-51-0
3
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-28-2 5757
4 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 979-32-8
5
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 57-63-6 5991
6
Polyestradiol phosphate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 28014-46-2
7
Orlistat Approved, Investigational Phase 4,Phase 2,Not Applicable 96829-58-2 3034010
8
Ganirelix Approved Phase 4,Early Phase 1 123246-29-7, 124904-93-4 25081094
9
Drospirenone Approved Phase 4,Phase 3,Phase 1,Not Applicable 67392-87-4 68873
10
Menotropins Approved Phase 4,Phase 2,Phase 1,Not Applicable 61489-71-2, 9002-68-0 5360545
11
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1 57-83-0 5994
12
Hydrocortisone Approved, Vet_approved Phase 4,Not Applicable,Early Phase 1 50-23-7 5754
13
Pioglitazone Approved, Investigational Phase 4,Not Applicable,Early Phase 1 111025-46-8 4829
14
Simvastatin Approved Phase 4,Phase 3,Not Applicable 79902-63-9 54454
15
Letrozole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 112809-51-5 3902
16
Zinc Approved, Investigational Phase 4,Early Phase 1,Not Applicable 7440-66-6 23994
17
Resveratrol Approved, Experimental, Investigational Phase 4,Phase 1,Not Applicable 501-36-0 445154
18
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-22-0 6013
19
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 71-58-9
20
Moxonidine Approved, Investigational Phase 4 75438-57-2 4810
21
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 616-91-1 12035
22
Liraglutide Approved Phase 4 204656-20-2 44147092
23
Leuprolide Approved, Investigational Phase 4,Phase 2,Not Applicable,Early Phase 1 53714-56-0 3911 657181
24
Citalopram Approved Phase 4 59729-33-8 2771
25
Epinephrine Approved, Vet_approved Phase 4,Not Applicable,Early Phase 1 51-43-4 5816
26
Racepinephrine Approved Phase 4,Not Applicable,Early Phase 1 329-65-7 838
27
Rosiglitazone Approved, Investigational Phase 4,Not Applicable 122320-73-4 77999
28
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
29
Hydroxocobalamin Approved Phase 4,Not Applicable 13422-51-0 11953898 44475014
30
Alogliptin Approved Phase 4 850649-61-5 11450633
31
Isotretinoin Approved Phase 4 4759-48-2 5538 5282379
32
Acarbose Approved, Investigational Phase 4,Not Applicable 56180-94-0 441184
33
Tamoxifen Approved Phase 4 10540-29-1 2733526
34
Exenatide Approved, Investigational Phase 4,Phase 2,Phase 3 141758-74-9 15991534
35
Desogestrel Approved Phase 4,Phase 3 54024-22-5 40973
36
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
37
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
38
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 77-92-9 311
39
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 59-30-3 6037
40
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 58-05-9 143 6006
41
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-14-6 5280793
42
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1406-16-2
43
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 3,Not Applicable 67-97-0 6221 5280795
44
Melatonin Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 73-31-4 896
45
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
46
Nicotinamide Approved, Investigational, Nutraceutical Phase 4 98-92-0 936
47
Cyanocobalamin Approved, Nutraceutical Phase 4,Not Applicable 68-19-9 44176380
48
Manganese Approved, Nutraceutical Phase 4 7439-96-5 27854
49
Methylcobalamin Approved, Experimental, Investigational, Nutraceutical Phase 4,Not Applicable 13422-55-4
50
Inulin Approved, Investigational, Nutraceutical Phase 4 9005-80-5 24763

Interventional clinical trials:

(show top 50) (show all 569)
# Name Status NCT ID Phase Drugs
1 Therapeutic Monitoring of Metformin in Women With Polycystic Ovary Syndrome Unknown status NCT01366391 Phase 4 Metformin
2 the Effect of Diane-35 Pretreatment on In-vitro Fertilization Outcome for Patients With Polycystic Ovary Syndrome Unknown status NCT01752270 Phase 4 Diane-35 pretreatment;Diane-35 pretreatment
3 The Effect of Weight Loss on Anti-Müllerian Hormone Levels in Women With Polycystic Ovary Syndrome (PCOS) Unknown status NCT01475019 Phase 4 Orlistat;Sibutramine
4 Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS) Unknown status NCT00378729 Phase 4 Metformin and FSHr
5 Endometrial Scratching During Laproscopic Ovarian Drilling in Subfertile PCOS Women Unknown status NCT02140398 Phase 4
6 Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS Unknown status NCT00461643 Phase 4 Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
7 Metformin in Infertile PCOS Patients Unknown status NCT00501904 Phase 4 Metformin
8 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT01246310 Phase 4
9 PCOS, Therapy and Markers of Cardiovascular Risk Unknown status NCT01798875 Phase 4 oral metformin;oral contraceptive
10 Metformin in Step-down Regimen Versus Conventional Low Dose Step-up Protocol in Patients With PCOS Undergoing IVF Unknown status NCT01438190 Phase 4 Metformin, gonadotropins in step-down regimen;Placebo, gonadotropins in step-up regimen
11 Metformin and Gestational Diabetes in High-risk Patients: a RCTs Unknown status NCT00883259 Phase 4 Metformin
12 Adding L-carnitine in Clomiphene Resistant Polycystic Ovary Improves the Quality of Ovulation and the Pregnancy Outcome Unknown status NCT01665547 Phase 4 l-carnitine
13 Comparison Between GnRH Agonist and GnRH Antagonist Protocols of Ovarian Stimulation in PCOS Patients Unknown status NCT00417144 Phase 4 Arvekap 0.1mg (Triptorelin, Ipsen, France);Ganirelix 0.25mg (Orgalutran, Organon, The Netherlands)
14 Hemocoagulation and Lipoperoxidation in Women Using Combined Oral Contraceptives, Correction by Antioxidants Unknown status NCT02027337 Phase 4 20 mcg ethinylestradiol /3 mg drospirenone;20 mcg ethinylestradiol/3 mg drospirenone and Selmevit;30 mcg ethinylestradiol/3 mg drospirenone;30 mcg ethinylestradiol/3 mg drospirenone and Selmevit;35 mcg ethinylestradiol/2 mg cyproterone;35 mcg ethinylestradiol/2 mg cyproterone and Selmevit
15 Corifollitropin Alfa Application in PCOS Patients Unknown status NCT02215135 Phase 4 Corifollitropin alfa
16 Metformin for the Treatment of Unexplained Oligozspermia Unknown status NCT01529177 Phase 4 Metformin / clomid / hCG;Clomiphene citrate / hCG
17 Efficacy of Corifollitropin Alfa in Obese Women in Terms of Clinical and Molecular Parameters of IVF Success Unknown status NCT02606500 Phase 4 Elonva
18 Polycystic Ovary Syndrome - Improving Outcomes Completed NCT01504321 Phase 4 Moxonidine;Placebo
19 Metformin and Lifestyle Intervention in Women With Polycystic Ovary Syndrome Completed NCT00679679 Phase 4 Metformin;Placebo
20 N-acetyl Cysteine for Ovulation Induction in Clomiphene Citrate Resistant Polycystic Ovary Syndrome Completed NCT02239107 Phase 4 N-Acetyl cysteine
21 Trial With Metformin in Women With Polycystic Ovary Syndrome Completed NCT02280057 Phase 4 Metformin;Placebo
22 PCOSMIC Trial - PolyCystic Ovary Syndrome, Metformin for Infertility With Clomiphene Completed NCT00795808 Phase 4 Metformin;Placebo;Metformin + Clomiphene;Metformin;Clomiphene
23 The Effects of Fish Oils on Blood Pressure, Heart Rate Variability and Liver Fat in the Polycystic Ovary Syndrome Completed NCT00620529 Phase 4
24 Effect of Nicotinic Acid on Cardiovascular Risks Indices in Polycystic Ovary Syndrome Completed NCT01118598 Phase 4 tredaptive (nicotinic acid/ laropiprant);placebo
25 Low Dose OC Therapy in Women With Polycystic Ovary Syndrome (PCOS): Impact of BMI on Hyperandrogenism Completed NCT01360996 Phase 4 3 mg DRSP/20 μg EE
26 LIPT - Liraglutide in Polycystic Ovary Syndrome Completed NCT02073929 Phase 4 Liraglutide;placebo
27 The Effect of Ethinyl Estradiol on Polycystic Ovary Syndrome Women Undergoing Intrauterine Insemination Completed NCT01219101 Phase 4 clomiphene citrate with ethinyl esteradiol;clomiphene citrate with plasebo
28 Menopur® Versus Follistim® in Polycystic Ovarian Syndrome (PCOS) Completed NCT00805935 Phase 4 Menotropin;Progesterone vaginal insert;Follitropin beta;Progesterone in oil;leuprolide acetate
29 The Effects of Vitamin D on Transforming Growth Factor-beta1 in Polycystic Ovary Syndrome Completed NCT02460380 Phase 4 Vitamin D3
30 Metformin and Folate Supplementation in Polycystic Ovary Syndrome (PCOS) Patients Completed NCT00953355 Phase 4 Folate plus metformin;Placebo plus metformin
31 Short-term Structured Exercise Training Program Plus Diet Intervention in Patients With Polycystic Ovary Syndrome (PCOS) Completed NCT01004068 Phase 4 Clomiphene citrate
32 Ovarian Stimulation and Intrauterine Insemination in Women With Polycystic Ovarian Syndrome Completed NCT01675843 Phase 4
33 Pioglitazone Treatment in Polycystic Ovary Syndrome Completed NCT00145340 Phase 4 pioglitazone
34 Effects of Metformin Plus Simvastatin on Polycystic Ovarian Syndrome (PCOS): A Prospective, Randomized, Double-Blind, Placebo-Controlled Study Completed NCT01021579 Phase 4 Metformin plus Placebo;Metfomin plus Simvastatin
35 Polycystic Ovary Syndrome and Liraglutide Completed NCT01899430 Phase 4 liraglutide;metformin
36 Phytoestrogens as an Alternative to Estradiol in Ovulation Induction in PCOS Completed NCT02352597 Phase 4 phytoestrogen;estradiol valerate;clomiphene citrate
37 Metformin and Folate in Pregnant Polycystic Ovary Syndrome(PCOS) Women Completed NCT01115140 Phase 4 metformin plus placebo;Metformin plus folic acid;placebo plus folic acid;placebo alone
38 Role of Melatonin Supplementation in Follicular Fluid of in Vitro Fertilization (IVF) Patients With Polycystic Ovarian Syndrome Completed NCT01540747 Phase 4
39 Polycystic Ovary Syndrome and Liraglutide as Add-on Therapy on Metformin Completed NCT01911468 Phase 4 metformin;liraglutide;metformin and liraglutide
40 The Effect of Cipralex on Quality of Life, Adrenal Activity Glucose Metabolism, Physical and Mental Health in PCOS Completed NCT01961180 Phase 4 Cipralex;Placebo
41 PDE-4 Inhibitor Roflumilast and Polycystic Ovary Syndrome Completed NCT02037672 Phase 4 metformin;metformin and roflumilast
42 PDE-4 Inhibitor Roflumilast and GLP-1 Agonist Liraglutide in Polycystic Ovary Syndrome Completed NCT02187250 Phase 4 metformin;liraglutide;roflumilast
43 The Effects of OCP and Metformin on Clinical, Hormonal, Metabolic and Ultrasonographic Characteristics in PCOS Completed NCT02866786 Phase 4 Metformin;ethinyl estradiol and cyproterone acetate
44 Insulin Resistance, Polycystic Ovary Syndrome, and Bone Research Study Completed NCT00640224 Phase 4 rosiglitazone;drospirenone/ethinyl estradiol
45 Effects of Metformin vs Oral Contraceptives on CV Risk Markers in PCOS Completed NCT00428311 Phase 4 Metformin;Ethynyl-estradiol plus cyproterone acetate
46 Incretin Effect in PCOS Women Completed NCT01892254 Phase 4 Metformin;Placebo
47 Letrozole Versus Clomifene Citrate for Ovulation Induction Completed NCT00478504 Phase 4 Letrozole;Clomifene citrate
48 Metformin in High Responder Polycystic Ovary Syndrome (PCOS) Patients Undergoing IVF Cycles Completed NCT01233206 Phase 4 Metformin;Placebo administration
49 Metformin Suspension and Insulin Sensitivity Completed NCT00437333 Phase 4 Metformin cloridrate
50 Clinical, Metabolic and Endocrine Effects of the Treatment With Drospirenone and Ethinyl Estradiol Alone or in Combination With Myo-inositol in Young Women With Polycystic Ovary Syndrome (PCOS) and Insulin Resistance Completed NCT01511822 Phase 4 Drospirenone Ethinyl estradiol;Drospirenone Ethinyl estradiol Myo-inositol;placebo

Search NIH Clinical Center for Polycystic Ovary Syndrome 1

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Polycystic Ovary Syndrome 1

Anatomical Context for Polycystic Ovary Syndrome 1

MalaCards organs/tissues related to Polycystic Ovary Syndrome 1:

41
Ovary, Liver, Brain, Bone, Pituitary, Heart, Endothelial

Publications for Polycystic Ovary Syndrome 1

Articles related to Polycystic Ovary Syndrome 1:

# Title Authors Year
1
The polycystic ovary syndrome. 1. Pathogenesis. ( 8012678 )
1994

Variations for Polycystic Ovary Syndrome 1

Expression for Polycystic Ovary Syndrome 1

Search GEO for disease gene expression data for Polycystic Ovary Syndrome 1.

Pathways for Polycystic Ovary Syndrome 1

GO Terms for Polycystic Ovary Syndrome 1

Sources for Polycystic Ovary Syndrome 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....