MCID: PLY036
MIFTS: 33

Polyembryoma

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Polyembryoma

MalaCards integrated aliases for Polyembryoma:

Name: Polyembryoma 54 60 74
Gonadal Polyembryoma 54 74

Classifications:



External Ids:

UMLS via Orphanet 75 C0334518
Orphanet 60 ORPHA180229

Summaries for Polyembryoma

NIH Rare Diseases : 54 Polyembryoma is a type of tumor that develops from the cells of the gonads (testes in men or ovaries in women).  Such tumors are called germ cell tumors.  Polyembryomas have a distinctive look because they are composed of many parts that are shaped like embryos, one of the earliest stages of a developing human during pregnancy.  Symptoms of a polyembryoma may include an unusual bump or mass in the abdomen which can cause pain in some individuals; puberty at an unusually young age (known as precocious puberty); or irregularities in a female's menstruation.  Treatment begins with surgery and may be followed by chemotherapy and/or radiation therapy.  The cause of polyembryoma is not yet known.

MalaCards based summary : Polyembryoma, also known as gonadal polyembryoma, is related to mixed germ cell tumor and teratoma. An important gene associated with Polyembryoma is CGA (Glycoprotein Hormones, Alpha Polypeptide), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Glucocorticoid receptor regulatory network. The drugs Cyclophosphamide and Captopril have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone and bone marrow.

Wikipedia : 77 Polyembryoma is a rare, very aggressive form of germ cell tumor usually found in the ovaries.... more...

Related Diseases for Polyembryoma

Graphical network of the top 20 diseases related to Polyembryoma:



Diseases related to Polyembryoma

Symptoms & Phenotypes for Polyembryoma

Drugs & Therapeutics for Polyembryoma

Drugs for Polyembryoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
2
Captopril Approved Phase 3 62571-86-2 44093
3
Palivizumab Approved, Investigational Phase 3 188039-54-5
4
Ribavirin Approved Phase 3 36791-04-5 37542
5
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
6
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
7
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
8
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
9
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 2826718 468682
10 Antineoplastic Agents, Alkylating Phase 3,Phase 2
11 HIV Protease Inhibitors Phase 3
12
protease inhibitors Phase 3
13 Angiotensin-Converting Enzyme Inhibitors Phase 3
14 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
15 Immunologic Factors Phase 3,Phase 2,Phase 1
16 Alkylating Agents Phase 3,Phase 2
17 Antihypertensive Agents Phase 3
18 Antirheumatic Agents Phase 3
19 Antibodies Phase 3,Phase 1
20 Antibodies, Monoclonal Phase 3,Phase 1
21 Antimetabolites Phase 3
22 Anti-Infective Agents Phase 3,Phase 2
23 Antiviral Agents Phase 3,Phase 2
24 Immunoglobulins Phase 3,Phase 1
25
Hydroxyitraconazole Phase 3
26 Cytochrome P-450 CYP2C19 Inhibitors Phase 3
27 Cytochrome P-450 Enzyme Inhibitors Phase 3
28 Cytochrome P-450 CYP3A Inhibitors Phase 3
29 Hormones Phase 3,Phase 1,Phase 2
30 Steroid Synthesis Inhibitors Phase 3
31 Hormone Antagonists Phase 3,Phase 1,Phase 2
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
33 Antifungal Agents Phase 3
34 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
35 Antiprotozoal Agents Phase 3
36 Antiparasitic Agents Phase 3
37 Liposomal amphotericin B Phase 3
38 Anti-Bacterial Agents Phase 3
39
Cisplatin Approved Phase 2 15663-27-1 441203 84093 2767
40
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
41
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
42
Ifosfamide Approved Phase 2 3778-73-2 3690
43
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
44
Lenograstim Approved, Investigational Phase 2 135968-09-1
45
Oprelvekin Approved, Investigational Phase 2 145941-26-0
46
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
47
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
48 Antineoplastic Agents, Phytogenic Phase 2
49 Antimitotic Agents Phase 2
50 Albumin-Bound Paclitaxel Phase 2

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
2 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
3 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
4 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
5 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
6 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
7 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
8 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
9 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
10 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
11 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
12 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
13 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
14 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
15 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Completed NCT01080521
16 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021 Not Applicable
17 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465 Not Applicable

Search NIH Clinical Center for Polyembryoma

Genetic Tests for Polyembryoma

Anatomical Context for Polyembryoma

MalaCards organs/tissues related to Polyembryoma:

42
Ovary, Bone, Bone Marrow, Brain, Colon, Breast, Small Intestine

Publications for Polyembryoma

Articles related to Polyembryoma:

(show all 16)
# Title Authors Year
1
Polyembryoma of the testis: a report of two cases dominant within mixed germ cell tumors and review of gonadal polyembryomas. ( 28429716 )
2017
2
The Polyembryoma: One of the Most Intriguing Human Neoplasms, With Comments on the Investigator Who Brought it to Light, Albert Peyron. ( 26840034 )
2016
3
Conservative management of ovarian mixed germ cell tumor associating polyembryoma and immature teratoma. ( 19437819 )
2008
4
Testicular mixed germ cell tumor with polyembryoma component in brothers. ( 15803215 )
2005
5
Mediastinal polyembryoma associated with Klinefelter syndrome. ( 12679648 )
2003
6
Ovarian mixed germ cell tumor with predominance of polyembryoma: a case report with literature review. ( 11781529 )
2002
7
Ovarian mixed germ cell tumor composed of polyembryoma and immature teratoma. ( 9648599 )
1998
8
Ovarian mixed germ cell tumor comprising polyembryoma and choriocarcinoma. ( 9605457 )
1998
9
[Histopathological and immunohistochemical study of ovarian polyembryoma]. ( 7538460 )
1995
10
Conservative management of an ovarian polyembryoma. ( 8159384 )
1994
11
Retroperitoneal giant tumor formed by migrating polyembryoma with numerous embryoid bodies from an ovarian mixed germ cell tumor. ( 1849112 )
1991
12
Mixed germ cell tumor of the ovary with a prominent polyembryoma component. ( 1848837 )
1991
13
Polyembryoma of testis. ( 2986435 )
1985
14
Polyembryoma of ovary producing alpha-fetoprotein and HCG: immunoperoxidase and electron microscopic study. ( 6176314 )
1982
15
Sexual precocity and thoracic polyembryoma: Klinefelter syndrome? ( 758406 )
1979
16
Sexual precocity in a male due to thoracic polyembryoma. ( 73579 )
1978

Variations for Polyembryoma

Expression for Polyembryoma

Search GEO for disease gene expression data for Polyembryoma.

Pathways for Polyembryoma

Pathways related to Polyembryoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.08 AFP SERPINA1
2 10.54 AFP CGA

GO Terms for Polyembryoma

Cellular components related to Polyembryoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.33 AFP CGA SERPINA1
2 endoplasmic reticulum lumen GO:0005788 8.96 AFP SERPINA1
3 extracellular space GO:0005615 8.8 AFP CGA SERPINA1

Biological processes related to Polyembryoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 8.96 AFP SERPINA1
2 cellular protein metabolic process GO:0044267 8.62 AFP SERPINA1

Sources for Polyembryoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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