MCID: PLY036
MIFTS: 30

Polyembryoma

Categories: Fetal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Polyembryoma

MalaCards integrated aliases for Polyembryoma:

Name: Polyembryoma 20 58 70
Gonadal Polyembryoma 20 70

Classifications:



External Ids:

UMLS via Orphanet 71 C0334518
Orphanet 58 ORPHA180229
UMLS 70 C0334518 C1880996

Summaries for Polyembryoma

GARD : 20 Polyembryoma is a type of tumor that develops from the cells of the gonads ( testes in men or ovaries in women). Such tumors are called germ cell tumors. Polyembryomas have a distinctive look because they are composed of many parts that are shaped like embryos, one of the earliest stages of a developing human during pregnancy. Symptoms of a polyembryoma may include an unusual bump or mass in the abdomen which can cause pain in some individuals; puberty at an unusually young age (known as precocious puberty ); or irregularities in a female's menstruation. Treatment begins with surgery and may be followed by chemotherapy and/or radiation therapy. The cause of polyembryoma is not yet known.

MalaCards based summary : Polyembryoma, also known as gonadal polyembryoma, is related to mixed germ cell tumor and teratoma. An important gene associated with Polyembryoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Glucocorticoid receptor regulatory network. Affiliated tissues include testes, ovary and testis, and related phenotypes are gonadal neoplasm and neuroectodermal neoplasm

Wikipedia : 73 Polyembryoma is a rare, very aggressive form of germ cell tumor usually found in the ovaries.... more...

Related Diseases for Polyembryoma

Diseases related to Polyembryoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 mixed germ cell tumor 30.2 CGA AFP
2 teratoma 30.2 CGA AFP
3 endodermal sinus tumor 30.1 SERPINA1 AFP
4 ovarian mixed germ cell neoplasm 29.6 SERPINA1 CGA AFP
5 testis polyembryoma 11.1
6 polyembryoma of the ovary 11.0
7 germ cells tumors 10.4
8 precocious puberty 10.2
9 choriocarcinoma 10.1
10 testicular yolk sac tumor 10.1
11 embryonal carcinoma 10.0
12 liver sarcoma 10.0 SERPINA1 AFP
13 bile duct cysts 10.0 SERPINA1 AFP
14 esophageal varix 10.0 SERPINA1 AFP
15 pancreatoblastoma 10.0 SERPINA1 AFP
16 hepatic tuberculosis 10.0 SERPINA1 AFP
17 plasma protein metabolism disease 9.9 SERPINA1 AFP
18 tyrosinemia, type i 9.9 SERPINA1 AFP
19 acinar cell carcinoma 9.9 SERPINA1 AFP
20 hepatic vascular disease 9.9 SERPINA1 AFP
21 metal metabolism disorder 9.9 SERPINA1 AFP
22 hepatitis a 9.9 SERPINA1 AFP
23 alpha-1-antitrypsin deficiency 9.9 SERPINA1 AFP
24 crigler-najjar syndrome, type i 9.9 SERPINA1 AFP
25 cholangitis, primary sclerosing 9.9 SERPINA1 AFP
26 viral hepatitis 9.9 SERPINA1 AFP
27 infant gynecomastia 9.9
28 gynecomastia 9.9
29 mature teratoma 9.9
30 biliary tract disease 9.9 SERPINA1 AFP
31 bilirubin metabolic disorder 9.9 SERPINA1 AFP
32 sacrococcygeal teratoma 9.8 CGA AFP
33 triploidy 9.8 CGA AFP
34 hemorrhagic disease 9.8 SERPINA1 AFP
35 hydrocele 9.8 CGA AFP
36 orofaciodigital syndrome viii 9.8 CGA AFP
37 trophoblastic neoplasm 9.8 CGA AFP
38 hemochromatosis, type 1 9.8 SERPINA1 AFP
39 germinoma 9.8 CGA AFP
40 oligohydramnios 9.8 CGA AFP
41 ectopic pregnancy 9.8 CGA AFP
42 placenta disease 9.7 CGA AFP
43 seminoma 9.7 CGA AFP
44 germ cell cancer 9.7 CGA AFP
45 liver disease 9.7 SERPINA1 AFP
46 cryptorchidism, unilateral or bilateral 9.7 CGA AFP
47 testicular cancer 9.7 CGA AFP
48 down syndrome 9.6 CGA AFP
49 liver cirrhosis 9.6 SERPINA1 AFP

Graphical network of the top 20 diseases related to Polyembryoma:



Diseases related to Polyembryoma

Symptoms & Phenotypes for Polyembryoma

Human phenotypes related to Polyembryoma:

58 31 (show all 19)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 gonadal neoplasm 58 31 frequent (33%) Frequent (79-30%) HP:0010785
2 neuroectodermal neoplasm 58 31 frequent (33%) Frequent (79-30%) HP:0030061
3 abnormal circulating gonadotropin level 58 31 frequent (33%) Frequent (79-30%) HP:0030338
4 abdominal pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0002027
5 abnormal sacrum morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0005107
6 elevated alpha-fetoprotein 58 31 occasional (7.5%) Occasional (29-5%) HP:0006254
7 abnormality of the peritoneum 58 31 occasional (7.5%) Occasional (29-5%) HP:0002585
8 abnormality of the mediastinum 58 31 occasional (7.5%) Occasional (29-5%) HP:0045026
9 neoplasm of head and neck 58 31 occasional (7.5%) Occasional (29-5%) HP:0012288
10 abdominal mass 58 31 occasional (7.5%) Occasional (29-5%) HP:0031500
11 abnormal onset of bleeding 58 31 occasional (7.5%) Occasional (29-5%) HP:0040231
12 macroorchidism 58 31 very rare (1%) Very rare (<4-1%) HP:0000053
13 fever 58 31 very rare (1%) Very rare (<4-1%) HP:0001945
14 abdominal distention 58 31 very rare (1%) Very rare (<4-1%) HP:0003270
15 irregular menstruation 58 31 very rare (1%) Very rare (<4-1%) HP:0000858
16 increased serum testosterone level 58 31 very rare (1%) Very rare (<4-1%) HP:0030088
17 isosexual precocious puberty 58 31 very rare (1%) Very rare (<4-1%) HP:0008236
18 increased serum serotonin 58 31 very rare (1%) Very rare (<4-1%) HP:0003144
19 abnormality of the endocrine system 58 Very rare (<4-1%)

Drugs & Therapeutics for Polyembryoma

Search Clinical Trials , NIH Clinical Center for Polyembryoma

Genetic Tests for Polyembryoma

Anatomical Context for Polyembryoma

MalaCards organs/tissues related to Polyembryoma:

40
Testes, Ovary, Testis, Liver, Spleen, Placenta

Publications for Polyembryoma

Articles related to Polyembryoma:

(show all 38)
# Title Authors PMID Year
1
Malignant Mixed Germ Cell Tumors of the Ovary: An Analysis of 100 Cases Emphasizing the Frequency and Interrelationships of Their Tumor Types. 61
33284192 2020
2
Polyembryoma of the testis: a report of two cases dominant within mixed germ cell tumors and review of gonadal polyembryomas. 61
28429716 2017
3
The Polyembryoma: One of the Most Intriguing Human Neoplasms, With Comments on the Investigator Who Brought it to Light, Albert Peyron. 61
26840034 2016
4
Testicular embryonal carcinoma: a morphologic study of 180 cases highlighting unusual and unemphasized aspects. 61
24503753 2014
5
Malignant mixed ovarian germ cell tumor with embryonal component. 61
20869284 2011
6
Morphologic, immunohistochemical, and fluorescence in situ hybridization study of ovarian embryonal carcinoma with comparison to solid variant of yolk sac tumor and immature teratoma. 61
20096442 2010
7
Testicular tumors--some new and a few perennial problems. 61
18384207 2008
8
Immunohistochemical expression of OCT4 in primary central nervous system germ cell tumours. 61
17997317 2008
9
Conservative management of ovarian mixed germ cell tumor associating polyembryoma and immature teratoma. 61
19437819 2008
10
Mediastinal germ cell tumor associated with histiocytic sarcoma of spleen: case report of an unusual association. 61
16086090 2005
11
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues. 61
15761467 2005
12
Pure nongestational choriocarcinoma of ovary. 61
14991382 2005
13
Testicular mixed germ cell tumor with polyembryoma component in brothers. 61
15803215 2005
14
Mediastinal polyembryoma associated with Klinefelter syndrome. 61
12679648 2003
15
[Polyembrioma of the testis: case report following chemotherapy for non-Hodgkin's lymphoma]. 61
12109226 2002
16
Ovarian mixed germ cell tumor with predominance of polyembryoma: a case report with literature review. 61
11781529 2002
17
Ovarian mixed germ cell tumor composed of polyembryoma and immature teratoma. 61
9648599 1998
18
Ovarian mixed germ cell tumor comprising polyembryoma and choriocarcinoma. 61
9605457 1998
19
Current management of malignant germ cell tumor of the ovary. 61
7661594 1995
20
[Histopathological and immunohistochemical study of ovarian polyembryoma]. 61
7538460 1995
21
Diffuse embryoma of the testis. An immunohistochemical study of two cases. 61
7524298 1994
22
Conservative management of an ovarian polyembryoma. 61
8159384 1994
23
Germ cell neoplasms of the testis. 61
8214253 1993
24
Prognostic factors in yolk sac tumors of the ovary. A clinicopathologic analysis of 29 cases. 61
1845936 1991
25
Mixed germ cell tumor of the ovary with a prominent polyembryoma component. 61
1848837 1991
26
Retroperitoneal giant tumor formed by migrating polyembryoma with numerous embryoid bodies from an ovarian mixed germ cell tumor. 61
1849112 1991
27
Alpha-fetoprotein in malignant germ cell tumors of the ovary. 61
1699854 1990
28
The frequency and histology of hepatic tissue in germ cell tumors. 61
2443027 1987
29
Immunohistochemical demonstration of alpha-fetoprotein in testicular germ cell tumors. 61
2426730 1986
30
Polyembryoma of testis. 61
2986435 1985
31
Pathology of germ cell tumors of testes. 61
3008176 1985
32
[Histopathology of testicular germ cell tumors]. 61
6210048 1984
33
[The pathology of germ cell tumors of the ovary]. 61
6095759 1984
34
Tumor markers and pathology of testicular tumors. 61
6206511 1984
35
[Germ cell tumors of testis: histological classification of 552 cases according to the WHO-nomenclature]. 61
6637191 1983
36
Polyembryoma of ovary producing alpha-fetoprotein and HCG: immunoperoxidase and electron microscopic study. 61
6176314 1982
37
Sexual precocity and thoracic polyembryoma: Klinefelter syndrome? 61
758406 1979
38
Sexual precocity in a male due to thoracic polyembryoma. 61
73579 1978

Variations for Polyembryoma

Expression for Polyembryoma

Search GEO for disease gene expression data for Polyembryoma.

Pathways for Polyembryoma

Pathways related to Polyembryoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.08 SERPINA1 AFP
2 10.54 CGA AFP

GO Terms for Polyembryoma

Cellular components related to Polyembryoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.13 SERPINA1 CGA AFP
2 endoplasmic reticulum lumen GO:0005788 8.62 SERPINA1 AFP

Biological processes related to Polyembryoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 8.96 SERPINA1 AFP
2 cellular protein metabolic process GO:0044267 8.62 SERPINA1 AFP

Sources for Polyembryoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....