Aliases & Classifications for Polyhydramnios

MalaCards integrated aliases for Polyhydramnios:

Name: Polyhydramnios 12 30 56 6 45 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:8488
ICD9CM 36 657 657.0
MeSH 45 D006831
NCIt 51 C92848
SNOMED-CT 69 86203003
ICD10 34 O40
UMLS 74 C0020224

Summaries for Polyhydramnios

Disease Ontology : 12 A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac.

MalaCards based summary : Polyhydramnios is related to polyhydramnios, megalencephaly, and symptomatic epilepsy and bartter disease, and has symptoms including morning sickness An important gene associated with Polyhydramnios is GLDN (Gliomedin), and among its related pathways/superpathways is Diuretics Pathway, Pharmacodynamics. The drugs Glyburide and Metformin have been mentioned in the context of this disorder. Affiliated tissues include placenta, kidney and heart, and related phenotypes are Decreased human cytomegalovirus (HCMV) strain AD169 replication and Decreased substrate adherent cell growth

Wikipedia : 77 Polyhydramnios is a medical condition describing an excess of amniotic fluid in the amniotic sac. It is... more...

Related Diseases for Polyhydramnios

Diseases related to Polyhydramnios via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 polyhydramnios, megalencephaly, and symptomatic epilepsy 34.4 STK11 STRADA
2 bartter disease 32.2 CLCNKB KCNJ1 SLC12A1
3 bartter syndrome, type 3 31.9 CLCNKB KCNJ1 SLC12A1
4 oligohydramnios 31.8 AFP AQP1 AQP3
5 antenatal bartter syndrome 30.2 KCNJ1 MAGED2 SLC12A1
6 chorioangioma 30.0 AFP FGFR3
7 diabetes insipidus, nephrogenic, autosomal 29.7 AQP1 AQP3 SLC12A1
8 polyhydramnios, chronic idiopathic 12.1
9 muscular hypertrophy-hepatomegaly-polyhydramnios syndrome 12.1
10 bartter syndrome, type 5, antenatal, transient 11.5
11 esophageal atresia 11.4
12 twin-to-twin transfusion syndrome 11.3
13 fetal akinesia syndrome, x-linked 11.1
14 chondrodysplasia, blomstrand type 11.1
15 pontocerebellar hypoplasia, type 4 11.1
16 bartter syndrome, type 2, antenatal 11.1
17 perlman syndrome 11.1
18 restrictive dermopathy, lethal 11.1
19 bartter syndrome, type 1, antenatal 11.1
20 lethal congenital contracture syndrome 7 11.1
21 bartter syndrome type 4 11.1
22 thanatophoric dysplasia, type ii 11.0
23 fetal akinesia deformation sequence 1 11.0
24 duodenal atresia 11.0
25 multiple pterygium syndrome, lethal type 11.0
26 spinal muscular atrophy, x-linked 2 11.0
27 megalencephaly-capillary malformation-polymicrogyria syndrome 11.0
28 bartter syndrome, type 4a, neonatal, with sensorineural deafness 11.0
29 bartter syndrome, type 4b, neonatal, with sensorineural deafness 11.0
30 nemaline myopathy 10 11.0
31 lethal congenital contracture syndrome 6 11.0
32 congenital chloride diarrhea 11.0
33 arterial calcification of infancy 11.0
34 tracheal agenesis 11.0
35 arthrogryposis, distal, type 1a 10.3 CNTNAP1 RAPSN
36 postsynaptic congenital myasthenic syndromes 10.3 MUSK RAPSN
37 brachial plexus neuritis 10.2 MTM1 MUSK
38 lymphatic malformation 7 10.2
39 fetal edema 10.2
40 hydrops fetalis 10.2
41 renal tubular transport disease 10.2 CLCNKB KCNJ1 SLC12A1
42 neonatal myasthenia gravis 10.2 AFP MUSK
43 gitelman syndrome 10.2 CLCNKB KCNJ1 SLC12A1
44 myotonic dystrophy 10.1
45 myotonia atrophica 10.1
46 hypokalemia 10.1 CLCNKB KCNJ1 SLC12A1
47 peripheral nervous system disease 10.1 MTM1 MUSK RAPSN
48 teratoma 10.1
49 congenital mesoblastic nephroma 10.1
50 nephrocalcinosis 10.1 CLCNKB KCNJ1 SLC12A1

Graphical network of the top 20 diseases related to Polyhydramnios:



Diseases related to Polyhydramnios

Symptoms & Phenotypes for Polyhydramnios

UMLS symptoms related to Polyhydramnios:


morning sickness

GenomeRNAi Phenotypes related to Polyhydramnios according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 9.26 FGFR3 MUSK STK11 STRADA
2 Decreased substrate adherent cell growth GR00193-A-1 9.02 STK11 STRADA
3 Decreased substrate adherent cell growth GR00193-A-3 9.02 FGFR3 STK11 STRADA

MGI Mouse Phenotypes related to Polyhydramnios:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.34 AFP AQP1 AQP3 CNTNAP1 FGFR3 GLDN
2 mortality/aging MP:0010768 10.31 AFP AQP1 AQP3 CNTNAP1 DYNC2H1 FGFR3
3 growth/size/body region MP:0005378 10.29 AQP1 AQP3 CNTNAP1 DYNC2H1 FGFR3 HSD17B4
4 homeostasis/metabolism MP:0005376 10.23 AFP AQP1 AQP3 CLCNKB FGFR3 HSD17B4
5 nervous system MP:0003631 10.11 AQP1 CNTNAP1 DYNC2H1 FGFR3 GLDN HSD17B4
6 muscle MP:0005369 9.95 CNTNAP1 HSD17B4 KCNQ1 MTM1 MUSK RAPSN
7 renal/urinary system MP:0005367 9.92 AQP1 AQP3 CLCNKB DYNC2H1 FGFR3 KCNJ1
8 reproductive system MP:0005389 9.91 AFP AQP1 CNTNAP1 FGFR3 HSD17B4 MTM1
9 respiratory system MP:0005388 9.81 AQP1 AQP3 DYNC2H1 FGFR3 MTM1 MUSK
10 skeleton MP:0005390 9.56 AQP1 AQP3 CNTNAP1 DYNC2H1 FGFR3 MTM1
11 vision/eye MP:0005391 9.17 AQP1 AQP3 CNTNAP1 DYNC2H1 FGFR3 HSD17B4

Drugs & Therapeutics for Polyhydramnios

Drugs for Polyhydramnios (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glyburide Approved Phase 4 10238-21-8 3488
2
Metformin Approved Phase 4 657-24-9 14219 4091
3 Hypoglycemic Agents Phase 4,Not Applicable
4 Acidophilus Phase 3
5
Betamethasone Approved, Vet_approved Phase 1, Phase 2 378-44-9 9782
6 Hormones Phase 1, Phase 2,Not Applicable
7 Anti-Inflammatory Agents Phase 1, Phase 2
8 Respiratory System Agents Phase 1, Phase 2
9 glucocorticoids Phase 1, Phase 2
10 Betamethasone benzoate Phase 1, Phase 2
11 Anti-Asthmatic Agents Phase 1, Phase 2
12 Betamethasone Valerate Phase 1, Phase 2 2152-44-5
13 Betamethasone-17,21-dipropionate Phase 1, Phase 2
14 Betamethasone sodium phosphate Phase 1, Phase 2
15 Hormone Antagonists Phase 1, Phase 2
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
17
leucovorin Approved 58-05-9 143 6006
18
Insulin Detemir Approved Not Applicable 169148-63-4 5311023
19
Zinc Approved, Investigational Not Applicable 7440-66-6 32051
20
Pancrelipase Approved, Investigational 53608-75-6
21
Vitamin D Approved, Nutraceutical, Vet_approved Not Applicable 1406-16-2
22
Calcium Approved, Nutraceutical Not Applicable 7440-70-2 271
23
Vitamin D3 Approved, Nutraceutical Not Applicable 67-97-0 5280795 6221
24
Ergocalciferol Approved, Nutraceutical Not Applicable 50-14-6 5280793
25
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
26 Trace Elements Not Applicable
27 Bone Density Conservation Agents Not Applicable
28 Calcium, Dietary Not Applicable
29 Ergocalciferols Not Applicable
30 Nutrients Not Applicable
31 Vitamins Not Applicable
32 Micronutrients Not Applicable
33 Vitamin D2 Not Applicable
34 Calciferol Not Applicable
35 Vitamin B Complex
36 Vitamin B9
37 Hematinics
38 Folate
39 Pharmaceutical Solutions Not Applicable
40 Insulin, Short-Acting Not Applicable
41 Insulin, Long-Acting Not Applicable
42 Isophane insulin, beef Not Applicable
43 Isophane Insulin, Human Not Applicable
44 Insulin, Isophane Not Applicable
45 insulin Not Applicable
46 Insulin, Globin Zinc Not Applicable
47 pancreatin
48 Vaccines Not Applicable
49 Antibodies Not Applicable
50 Immunoglobulins Not Applicable

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus Completed NCT01563120 Phase 4 metformin;glybenclamide
2 Probiotics (Lactobacillus Rhamnosus) in Reducing Glucose Intolerance During and After Pregnancy Unknown status NCT01436448 Phase 3 Probiotics Lactobacillus Rhamnosus
3 Syringe or Continuous Amnioreduction for Symptomatic Polyhydramnios. A Prospective Randomized Study. Completed NCT00236340 Phase 3
4 Tracheal Occlusion To Accelerate Lung Growth (TOTAL) Trial for Severe Pulmonary Hypoplasia Recruiting NCT01240057 Phase 2, Phase 3
5 The Safety, Tolerability And Metabolism Of GSK221149A, In Pregnant Women (30-36 Weeks), In Pre-Term Labor Completed NCT00404768 Phase 2 GSK221149A;Placebo
6 Prenatal Steroids for Treatment of Congenital Cystic Adenomatoid Malformations (CCAM) Terminated NCT00670956 Phase 1, Phase 2 Betamethasone;Placebo
7 Sonographic Assessment of Fetal Deglutition Associated With Hydramnion:Its Absence is Indicative of Central Nervous System (CNS) Pathology Unknown status NCT00687752
8 The Value of Prenatal Ultrasound in Complicated Twin Pregnancy and Its Correlation With Chromosomal Anomalies Unknown status NCT02732717
9 Vitamin D Treatment and Hypocalcemic Pregnant Women Unknown status NCT02021864 Not Applicable vitamin D3 50,000 unit;prenatal multivitamin
10 Diabetes Mellitus With Pregnancy in Benisuef Localities Unknown status NCT03169205
11 Myo-inositol, D-chiro-inositol, and D-chiro/Myo-inositol in Gestational Diabetes Unknown status NCT01762826
12 One Step Versus Two Step Approach for Gestational Diabetes Mellitus Screening Unknown status NCT03073330 Not Applicable
13 Studying Fetal Breathing Patterns Completed NCT00066976
14 Chewing Gums to Stimulate Intestinal Motility After Cesarean Section Completed NCT02386748 Not Applicable
15 Maternal and Perinatal Outcome in Women With History of Premature Labor in Previous Pregnancy Completed NCT01375439 Not Applicable
16 Determination of Abnormal Fetal Growth or Amniotic Fluid With Third Trimester Ultrasounds in Uncomplicated Pregnancies: A Randomized Trial Completed NCT02702999 Not Applicable
17 Improved Outcomes Associated With Inositol Dietary Supplementation in Women With Gestational Diabetes Mellitus Completed NCT01342874
18 Glycemic Control Using Insulin Levemir Versus Insulin NPH for Diabetes in Pregnancy Completed NCT01837680 Not Applicable Insulin
19 Fetoscopic Endoluminal Tracheal Occlusion (FETO) for Congenital Diaphragm Hernia Completed NCT02596802 Not Applicable
20 Uterocervical Angle in Idiopathic Polyhydramnios Recruiting NCT03828695 Not Applicable
21 Fetoscopic Endoluminal Tracheal Occlusion (FETO) Recruiting NCT03674372 Not Applicable
22 Real-time Continuous Glucose Monitoring Recruiting NCT03326232 Not Applicable
23 Intra-abdominal Umbilical Vein Aneurysm Recruiting NCT03653884
24 Pregnancy Outcomes and Medical Costs According to Gestational Diabetes Mellitus Diagnostic Criteria Recruiting NCT03421262 Not Applicable
25 Longitudinal Observation of Insulin Requirements and Sensor Use in Pregnancy Recruiting NCT03761615
26 Does Amniotic Fluid Index Affect the Fetal Cardiac Performance? Not yet recruiting NCT03277417
27 A Study of Outcomes and Events of Interest in Pregnant Women, Neonates and Infants and of RSV Surveillance Not yet recruiting NCT03614676 Not Applicable
28 Is Vitamin D Insufficiency and Deficiency Associated With Antepartum and Postpartum Depression? Terminated NCT02272387 Not Applicable

Search NIH Clinical Center for Polyhydramnios

Cochrane evidence based reviews: polyhydramnios

Genetic Tests for Polyhydramnios

Genetic tests related to Polyhydramnios:

# Genetic test Affiliating Genes
1 Polyhydramnios 30

Anatomical Context for Polyhydramnios

MalaCards organs/tissues related to Polyhydramnios:

42
Placenta, Kidney, Heart, Bone, Brain, Small Intestine, Tongue

Publications for Polyhydramnios

Articles related to Polyhydramnios:

(show top 50) (show all 362)
# Title Authors Year
1
Placental chorioangioma associated with polyhydramnios and hydrops fetalis. ( 30700468 )
2019
2
A step towards precision medicine in management of severe transient polyhydramnios: MAGED2 variant. ( 29893154 )
2019
3
A novel differential diagnosis to nonobstructive diffuse and dilated bowel loops with polyhydramnios: Bartter syndrome. ( 30246465 )
2019
4
The association between polyhydramnios and the risk of placenta abruption: a meta-analysis. ( 30624999 )
2019
5
Prenatal progressive cardiomegaly and functional pulmonary atresia on one fetus of monochorionic diamniotic twin pregnancy regardless of spontaneous resolution of isolated polyhydramnios. ( 30638480 )
2019
6
Effect of intra-amniotic fluid pressure from polyhydramnios on cervical length in patients with twin-twin transfusion syndrome undergoing fetoscopic laser surgery. ( 30693576 )
2019
7
Relationship between higher intra-amniotic pressures in polyhydramnios and maternal symptoms. ( 30797177 )
2019
8
Follow-up of children with antenatally diagnosed idiopathic polyhydramnios. ( 30860276 )
2019
9
First confirmation of the hypothesis that polyhydramnios causes bone maldevelopment. ( 30915876 )
2019
10
Placental abruption after amnioreduction for polyhydramnios caused by chorioangioma. ( 29507014 )
2018
11
Novel Homozygous Deletion in STRADA Gene Associated With Polyhydramnios, Megalencephaly, and Epilepsy in 2 Siblings: Implications for Diagnosis and Treatment. ( 30311510 )
2018
12
Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter? ( 29076544 )
2018
13
Preterm Parturient with Polyhydramnios and Pancreatitis: Primary Presentation of Hyperparathyroidism. ( 29607233 )
2018
14
Fetal Goitrous Hypothyroidism and Polyhydramnios in a Patient with Compound Heterozygous DUOXA2 Mutations. ( 30110704 )
2018
15
Fetal brain MRI in polyhydramnios: is it justified? ( 29865922 )
2018
16
SMFM Consult Series #46: Evaluation and management of polyhydramnios. ( 30048635 )
2018
17
The effect of increased amnion volume severity on fetal Doppler indices and perinatal outcomes in idiopathic polyhydramnios. ( 30081701 )
2018
18
Transient Isolated Polyhydramnios and Perinatal Outcomes. ( 30253428 )
2018
19
Prenatal drainage of fetal urinoma with polyhydramnios: a case report and literature review. ( 28076981 )
2018
20
Perinatal outcome in pregnancy with polyhydramnios in comparison with normal pregnancy in department of obstetrics at Shiraz University of Medical Sciences. ( 28462606 )
2018
21
Polyhydramnios or Excessive Fetal Growth Are Markers for Abnormal Perinatal Outcome in Euglycemic Pregnancies. ( 28838004 )
2018
22
Polyhydramnios Affecting a Recipient-like Twin: Risk of Progression to Twin-Twin Transfusion Syndrome and Outcomes. ( 29287298 )
2018
23
Targeted gene panel sequencing prenatally detects two novel mutations of DYNC2H1 in a fetus with increased biparietal diameter and polyhydramnios. ( 29359448 )
2018
24
Isolated polyhydramnios in the third trimester: is a gestational diabetes evaluation of value? ( 28488900 )
2017
25
Fetal hypothyroidism induced by maternal anti-TSH receptor blocking antibodies and complicated by polyhydramnios despite the absence of goiter. Treatment by intra-amniotic injections of levothyroxine. ( 27919402 )
2017
26
Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a thyroglobulin mutation. ( 28620499 )
2017
27
Pregnant woman with polyhydramnios and fetus with small intestinal atresia. ( 28925193 )
2017
28
Idiopathic polyhydramnios at term and pregnancy outcomes: a multicenter observational study. ( 27625160 )
2017
29
Polyhydramnios in isolated oral cleft pregnancies: incidence and outcome in a retrospective study. ( 27943390 )
2017
30
Mode of delivery among women admitted with polyhydramnios. ( 28019126 )
2017
31
Amount of polyhydramnios attributable to diabetes may be less than previously reported. ( 28138359 )
2017
32
Outcome of pregnancy in women diagnosed with idiopathic polyhydramnios. ( 28251633 )
2017
33
Delivery outcomes of term pregnancy complicated by idiopathic polyhydramnios. ( 28643663 )
2017
34
Polyhydramnios - frequency of congenital anomalies in relation to the value of the amniotic fluid index. ( 28930371 )
2017
35
The relation between causes and onset time of polyhydramnios. ( 29714878 )
2017
36
A Case of the TOF with APV Complicated with Polyhydramnios and Severe Bronchomalacia. ( 27579200 )
2016
37
Pregnancy after oocyte donation in 45, X Turner syndrome women, complicated by gestational diabetes and polyhydramnios. Case report and mini-review of literature. ( 26942946 )
2016
38
Molecular cytogenetic characterization of inv dup del(8p) in a fetus associated with ventriculomegaly, hypoplastic left heart, polyhydramnios and intestinal obstruction. ( 27343326 )
2016
39
Whole exome sequencing identifies the first STRADA point mutation in a patient with polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome (PMSE). ( 27170158 )
2016
40
Polyhydramnios and cerebellar atrophy: a prenatal presentation of mitochondrial encephalomyopathy caused by mutations in the FBXL4 gene. ( 27099744 )
2016
41
Variable genetic penetrance of myotonic dystrophy following the diagnosis of idiopathic polyhydramnios. ( 27039051 )
2016
42
Foetal biometry in polyhydramnios: Does femur length fall behind? ( 26467094 )
2016
43
Prenatal Diagnosis and Pregnancy Outcome Analysis of Polyhydramnios. ( 26720631 )
2016
44
Outcomes From Polyhydramnios With Normal Ultrasound. ( 26755694 )
2016
45
Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance. ( 26847765 )
2016
46
Idiopathic Polyhydramnios: Severity and Perinatal Morbidity. ( 26862725 )
2016
47
Intrapartum, postpartum characteristics and early neonatal outcomes of idiopathic polyhydramnios. ( 26926000 )
2016
48
Rapid Resolution of Polyhydramnios Foretells Circulatory Collapse for the Donor Twin in Feto-Fetal Transfusion Syndrome. ( 26932285 )
2016
49
Idiopathic polyhydramnios: persistence across gestation and impact on pregnancy outcomes. ( 26937648 )
2016
50
Pregnancy outcomes in severe polyhydramnios: no increase in risk in patients needing amnioreduction for maternal pain or respiratory distress. ( 26948899 )
2016

Variations for Polyhydramnios

ClinVar genetic disease variations for Polyhydramnios:

6 (show all 11)
# Gene Variation Type Significance SNP ID Assembly Location
1 KCNQ1 NM_000218.2(KCNQ1): c.1085A> G (p.Lys362Arg) single nucleotide variant Pathogenic/Likely pathogenic rs12720458 GRCh37 Chromosome 11, 2606494: 2606494
2 KCNQ1 NM_000218.2(KCNQ1): c.1085A> G (p.Lys362Arg) single nucleotide variant Pathogenic/Likely pathogenic rs12720458 GRCh38 Chromosome 11, 2585264: 2585264
3 46;XX;t(10;15)(q25.2;q11.2) Translocation Pathogenic
4 STRADA NM_001003787.3(STRADA): c.792T> A (p.Ser264Arg) single nucleotide variant Uncertain significance rs1057519011 GRCh37 Chromosome 17, 61784061: 61784061
5 STRADA NM_001003787.3(STRADA): c.792T> A (p.Ser264Arg) single nucleotide variant Uncertain significance rs1057519011 GRCh38 Chromosome 17, 63706701: 63706701
6 GLDN NM_181789.3(GLDN): c.1305G> A (p.Trp435Ter) single nucleotide variant Pathogenic/Likely pathogenic rs775011495 GRCh37 Chromosome 15, 51696600: 51696600
7 GLDN NM_181789.3(GLDN): c.1305G> A (p.Trp435Ter) single nucleotide variant Pathogenic/Likely pathogenic rs775011495 GRCh38 Chromosome 15, 51404403: 51404403
8 ABCC8 NM_000352.4(ABCC8): c.1024G> T (p.Gly342Trp) single nucleotide variant Likely pathogenic rs763028380 GRCh37 Chromosome 11, 17474818: 17474818
9 ABCC8 NM_000352.4(ABCC8): c.1024G> T (p.Gly342Trp) single nucleotide variant Likely pathogenic rs763028380 GRCh38 Chromosome 11, 17453271: 17453271
10 MTM1 NM_000252.2(MTM1): c.1262G> T (p.Arg421Leu) single nucleotide variant Pathogenic GRCh37 Chromosome X, 149828138: 149828138
11 MTM1 NM_000252.2(MTM1): c.1262G> T (p.Arg421Leu) single nucleotide variant Pathogenic GRCh38 Chromosome X, 150659665: 150659665

Expression for Polyhydramnios

Search GEO for disease gene expression data for Polyhydramnios.

Pathways for Polyhydramnios

Pathways related to Polyhydramnios according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.26 CLCNKB KCNJ1 SLC12A1

GO Terms for Polyhydramnios

Cellular components related to Polyhydramnios according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.77 AQP1 AQP3 CLCNKB DYNC2H1 FGFR3 GLDN
2 membrane GO:0016020 9.53 AQP1 AQP3 CLCNKB CNTNAP1 DYNC2H1 FGFR3
3 voltage-gated potassium channel complex GO:0008076 9.33 CNTNAP1 KCNJ1 KCNQ1

Biological processes related to Polyhydramnios according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.72 AQP1 AQP3 CLCNKB KCNQ1 SLC12A1
2 potassium ion transmembrane transport GO:0071805 9.58 AQP1 KCNJ1 KCNQ1
3 potassium ion transport GO:0006813 9.46 AQP1 KCNJ1 KCNQ1 SLC12A1
4 cell volume homeostasis GO:0006884 9.43 AQP1 SLC12A1
5 water transport GO:0006833 9.37 AQP1 AQP3
6 glycerol transport GO:0015793 9.26 AQP1 AQP3
7 excretion GO:0007588 9.13 AQP3 CLCNKB KCNJ1
8 ion transmembrane transport GO:0034220 9.02 AQP1 CLCNKB KCNJ1 KCNQ1 SLC12A1

Molecular functions related to Polyhydramnios according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 water channel activity GO:0015250 8.62 AQP1 AQP3

Sources for Polyhydramnios

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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