Aliases & Classifications for Polyhydramnios

MalaCards integrated aliases for Polyhydramnios:

Name: Polyhydramnios 12 29 55 6 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:8488
ICD10 33 O40
ICD9CM 35 657 657.0
MeSH 44 D006831
NCIt 50 C92848
SNOMED-CT 68 86203003
UMLS 73 C0020224

Summaries for Polyhydramnios

Disease Ontology : 12 A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac.

MalaCards based summary : Polyhydramnios is related to polyhydramnios, megalencephaly, and symptomatic epilepsy and bartter disease, and has symptoms including morning sickness An important gene associated with Polyhydramnios is GLDN (Gliomedin), and among its related pathways/superpathways are Vasopressin-regulated water reabsorption and LKB1 signaling events. The drugs Metformin and Glyburide have been mentioned in the context of this disorder. Affiliated tissues include placenta, brain and lung, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Wikipedia : 76 Polyhydramnios is a medical condition describing an excess of amniotic fluid in the amniotic sac. It is... more...

Related Diseases for Polyhydramnios

Diseases related to Polyhydramnios via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Related Disease Score Top Affiliating Genes
1 polyhydramnios, megalencephaly, and symptomatic epilepsy 34.1 STK11 STRADA
2 bartter disease 31.9 CLCNKB KCNJ1 SLC12A1
3 oligohydramnios 31.6 AFP AQP1 AQP3
4 bartter syndrome, type 3 31.6 CLCNKB KCNJ1 SLC12A1
5 chorioangioma 30.3 AFP FGFR3
6 antenatal bartter syndrome 29.8 KCNJ1 MAGED2 SLC12A1
7 diabetes insipidus, nephrogenic, autosomal 29.4 AQP1 AQP3 SLC12A1
8 polyhydramnios, chronic idiopathic 12.0
9 muscular hypertrophy-hepatomegaly-polyhydramnios syndrome 12.0
10 esophageal atresia 11.4
11 twin-to-twin transfusion syndrome 11.3
12 bartter syndrome, type 5, antenatal, transient 11.2
13 fetal akinesia syndrome, x-linked 11.1
14 chondrodysplasia, blomstrand type 11.1
15 pontocerebellar hypoplasia, type 4 11.1
16 bartter syndrome, type 2, antenatal 11.1
17 perlman syndrome 11.1
18 restrictive dermopathy, lethal 11.1
19 bartter syndrome, type 1, antenatal 11.1
20 lethal congenital contracture syndrome 7 11.1
21 bartter syndrome type 4 11.1
22 thanatophoric dysplasia, type ii 10.9
23 fetal akinesia deformation sequence 10.9
24 duodenal atresia 10.9
25 multiple pterygium syndrome, lethal type 10.9
26 spinal muscular atrophy, x-linked 2 10.9
27 megalencephaly-capillary malformation-polymicrogyria syndrome 10.9
28 bartter syndrome, type 4a, neonatal, with sensorineural deafness 10.9
29 bartter syndrome, type 4b, neonatal, with sensorineural deafness 10.9
30 nemaline myopathy 10 10.9
31 lethal congenital contracture syndrome 6 10.9
32 congenital chloride diarrhea 10.9
33 tracheal agenesis 10.9
34 hydrops fetalis, nonimmune, and/or atrial septal defect 10.1
35 myotonic dystrophy 10.1
36 fetal edema 10.1
37 hydrops fetalis 10.1
38 myotonia atrophica 10.1
39 teratoma 10.1
40 congenital mesoblastic nephroma 10.1
41 seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance 10.0 AQP3 KCNJ1
42 mineral metabolism disease 10.0 CLCNKB KCNJ1
43 dowling-degos disease 1 10.0 FGFR3 STK11
44 renal tubular transport disease 10.0 CLCNKB KCNJ1 SLC12A1
45 diaphragmatic hernia, congenital 10.0
46 hydronephrosis 10.0
47 hypothyroidism 10.0
48 epilepsy 10.0
49 ovarian cyst 10.0
50 megalencephaly 10.0

Graphical network of the top 20 diseases related to Polyhydramnios:



Diseases related to Polyhydramnios

Symptoms & Phenotypes for Polyhydramnios

UMLS symptoms related to Polyhydramnios:


morning sickness

GenomeRNAi Phenotypes related to Polyhydramnios according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.02 STK11 STRADA
2 Decreased substrate adherent cell growth GR00193-A-3 9.02 FGFR3 STK11 STRADA

MGI Mouse Phenotypes related to Polyhydramnios:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 AFP AQP1 AQP3 CNTNAP1 FGFR3 GLDN
2 growth/size/body region MP:0005378 10.02 AQP1 AQP3 CNTNAP1 DYNC2H1 FGFR3 HSD17B4
3 mortality/aging MP:0010768 10 AFP AQP1 AQP3 CNTNAP1 DYNC2H1 FGFR3
4 homeostasis/metabolism MP:0005376 9.97 AFP AQP1 AQP3 CLCNKB FGFR3 HSD17B4
5 renal/urinary system MP:0005367 9.76 AQP1 AQP3 CLCNKB DYNC2H1 FGFR3 KCNJ1
6 reproductive system MP:0005389 9.5 AFP AQP1 CNTNAP1 FGFR3 HSD17B4 SLC12A1
7 vision/eye MP:0005391 9.17 AQP1 AQP3 CNTNAP1 DYNC2H1 FGFR3 HSD17B4

Drugs & Therapeutics for Polyhydramnios

Drugs for Polyhydramnios (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 14219 4091
2
Glyburide Approved Phase 4 10238-21-8 3488
3 Hypoglycemic Agents Phase 4,Not Applicable
4 Acidophilus Phase 3
5
Betamethasone Approved, Vet_approved Phase 1, Phase 2 378-44-9 9782
6 glucocorticoids Phase 1, Phase 2
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
8 Respiratory System Agents Phase 1, Phase 2
9 Betamethasone Valerate Phase 1, Phase 2 2152-44-5
10 Hormone Antagonists Phase 1, Phase 2
11 Betamethasone-17,21-dipropionate Phase 1, Phase 2
12 Anti-Inflammatory Agents Phase 1, Phase 2
13 Hormones Phase 1, Phase 2
14 Anti-Asthmatic Agents Phase 1, Phase 2
15 Betamethasone sodium phosphate Phase 1, Phase 2
16 Betamethasone benzoate Phase 1, Phase 2
17
leucovorin Approved 58-05-9 6006 143
18
Zinc Approved, Investigational Not Applicable 7440-66-6
19
Insulin Detemir Approved Not Applicable 169148-63-4 5311023
20
Ergocalciferol Approved, Nutraceutical Not Applicable 50-14-6 5280793
21
Vitamin D Approved, Nutraceutical, Vet_approved Not Applicable 1406-16-2
22
Vitamin D3 Approved, Nutraceutical Not Applicable 67-97-0 5280795 6221
23
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
24 Vitamins Not Applicable
25 Trace Elements Not Applicable
26 Ergocalciferols Not Applicable
27 Vitamin D2 Not Applicable
28 Calciferol Not Applicable
29 Bone Density Conservation Agents Not Applicable
30 Micronutrients Not Applicable
31 Calcium, Dietary Not Applicable
32 Folate
33 Vitamin B9
34 Hematinics
35 Vitamin B Complex
36 Pharmaceutical Solutions Not Applicable
37 Insulin, Isophane Not Applicable
38 Isophane Insulin, Human Not Applicable
39 insulin Not Applicable
40 Isophane insulin, beef Not Applicable
41 Insulin, Globin Zinc Not Applicable
42 Insulin, Short-Acting Not Applicable
43 Insulin, Long-Acting Not Applicable
44 Antibodies Not Applicable
45 Immunoglobulins Not Applicable
46 Vaccines Not Applicable

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus Completed NCT01563120 Phase 4 metformin;glybenclamide
2 Probiotics (Lactobacillus Rhamnosus) in Reducing Glucose Intolerance During and After Pregnancy Unknown status NCT01436448 Phase 3 Probiotics Lactobacillus Rhamnosus
3 Syringe or Continuous Amnioreduction for Symptomatic Polyhydramnios. A Prospective Randomized Study. Completed NCT00236340 Phase 3
4 Tracheal Occlusion To Accelerate Lung Growth (TOTAL) Trial for Severe Pulmonary Hypoplasia Recruiting NCT01240057 Phase 2, Phase 3
5 The Safety, Tolerability And Metabolism Of GSK221149A, In Pregnant Women (30-36 Weeks), In Pre-Term Labor Completed NCT00404768 Phase 2 GSK221149A;Placebo
6 Prenatal Steroids for Treatment of Congenital Cystic Adenomatoid Malformations (CCAM) Terminated NCT00670956 Phase 1, Phase 2 Betamethasone;Placebo
7 Sonographic Assessment of Fetal Deglutition Associated With Hydramnion:Its Absence is Indicative of Central Nervous System (CNS) Pathology Unknown status NCT00687752
8 The Value of Prenatal Ultrasound in Complicated Twin Pregnancy and Its Correlation With Chromosomal Anomalies Unknown status NCT02732717
9 Vitamin D Treatment and Hypocalcemic Pregnant Women Unknown status NCT02021864 Not Applicable vitamin D3 50,000 unit;prenatal multivitamin
10 Myo-inositol, D-chiro-inositol, and D-chiro/Myo-inositol in Gestational Diabetes Unknown status NCT01762826
11 Studying Fetal Breathing Patterns Completed NCT00066976
12 Chewing Gums to Stimulate Intestinal Motility After Cesarean Section Completed NCT02386748 Not Applicable
13 Maternal and Perinatal Outcome in Women With History of Premature Labor in Previous Pregnancy Completed NCT01375439 Not Applicable
14 Determination of Abnormal Fetal Growth or Amniotic Fluid With Third Trimester Ultrasounds in Uncomplicated Pregnancies: A Randomized Trial Completed NCT02702999 Not Applicable
15 Improved Outcomes Associated With Inositol Dietary Supplementation in Women With Gestational Diabetes Mellitus Completed NCT01342874
16 Glycemic Control Using Insulin Levemir Versus Insulin NPH for Diabetes in Pregnancy Completed NCT01837680 Not Applicable Insulin
17 Fetoscopic Endoluminal Tracheal Occlusion (FETO) for Congenital Diaphragm Hernia Completed NCT02596802 Not Applicable
18 Fetoscopic Endoluminal Tracheal Occlusion (FETO) Recruiting NCT03674372 Not Applicable
19 Real-time Continuous Glucose Monitoring Recruiting NCT03326232 Not Applicable
20 Intra-abdominal Umbilical Vein Aneurysm Recruiting NCT03653884
21 One Step Versus Two Step Approach for Gestational Diabetes Mellitus Screening Recruiting NCT03073330 Not Applicable
22 Pregnancy Outcomes and Medical Costs According to Gestational Diabetes Mellitus Diagnostic Criteria Recruiting NCT03421262 Not Applicable
23 Longitudinal Observation of Insulin Requirements and Sensor Use in Pregnancy Recruiting NCT03761615
24 Diabetes Mellitus With Pregnancy in Benisuef Localities Enrolling by invitation NCT03169205
25 Does Amniotic Fluid Index Affect the Fetal Cardiac Performance? Not yet recruiting NCT03277417
26 A Study of Outcomes and Events of Interest in Pregnant Women, Neonates and Infants and of RSV Surveillance Not yet recruiting NCT03614676 Not Applicable
27 Is Vitamin D Insufficiency and Deficiency Associated With Antepartum and Postpartum Depression? Terminated NCT02272387 Not Applicable

Search NIH Clinical Center for Polyhydramnios

Cochrane evidence based reviews: polyhydramnios

Genetic Tests for Polyhydramnios

Genetic tests related to Polyhydramnios:

# Genetic test Affiliating Genes
1 Polyhydramnios 29

Anatomical Context for Polyhydramnios

MalaCards organs/tissues related to Polyhydramnios:

41
Placenta, Brain, Lung, Kidney, Heart, Bone, Small Intestine

Publications for Polyhydramnios

Articles related to Polyhydramnios:

(show top 50) (show all 355)
# Title Authors Year
1
Targeted gene panel sequencing prenatally detects two novel mutations of DYNC2H1 in a fetus with increased biparietal diameter and polyhydramnios. ( 29359448 )
2018
2
A step towards precision medicine in management of severe transient polyhydramnios: MAGED2 variant. ( 29893154 )
2018
3
Placental abruption after amnioreduction for polyhydramnios caused by chorioangioma. ( 29507014 )
2018
4
Preterm Parturient with Polyhydramnios and Pancreatitis: Primary Presentation of Hyperparathyroidism. ( 29607233 )
2018
5
Fetal brain MRI in polyhydramnios: is it justified? ( 29865922 )
2018
6
Novel Homozygous Deletion in STRADA Gene Associated With Polyhydramnios, Megalencephaly, and Epilepsy in 2 Siblings: Implications for Diagnosis and Treatment. ( 30311510 )
2018
7
Fetal Goitrous Hypothyroidism and Polyhydramnios in a Patient with Compound Heterozygous DUOXA2 Mutations. ( 30110704 )
2018
8
Prenatal drainage of fetal urinoma with polyhydramnios: a case report and literature review. ( 28076981 )
2018
9
SMFM Consult Series #46: Evaluation and management of polyhydramnios. ( 30048635 )
2018
10
The effect of increased amnion volume severity on fetal Doppler indices and perinatal outcomes in idiopathic polyhydramnios. ( 30081701 )
2018
11
A novel differential diagnosis to nonobstructive diffuse and dilated bowel loops with polyhydramnios: Bartter syndrome. ( 30246465 )
2018
12
Transient Isolated Polyhydramnios and Perinatal Outcomes. ( 30253428 )
2018
13
Pregnant woman with polyhydramnios and fetus with small intestinal atresia. ( 28925193 )
2017
14
Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a thyroglobulin mutation. ( 28620499 )
2017
15
The relation between causes and onset time of polyhydramnios. ( 29714878 )
2017
16
Perinatal outcome in pregnancy with polyhydramnios in comparison with normal pregnancy in department of obstetrics at Shiraz University of Medical Sciences. ( 28462606 )
2017
17
Amount of polyhydramnios attributable to diabetes may be less than previously reported. ( 28138359 )
2017
18
Delivery outcomes of term pregnancy complicated by idiopathic polyhydramnios. ( 28643663 )
2017
19
Polyhydramnios or Excessive Fetal Growth Are Markers for Abnormal Perinatal Outcome in Euglycemic Pregnancies. ( 28838004 )
2017
20
Polyhydramnios - frequency of congenital anomalies in relation to the value of the amniotic fluid index. ( 28930371 )
2017
21
Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter? ( 29076544 )
2017
22
Polyhydramnios Affecting a Recipient-like Twin: Risk of Progression to Twin-Twin Transfusion Syndrome and Outcomes. ( 29287298 )
2017
23
Outcome of pregnancy in women diagnosed with idiopathic polyhydramnios. ( 28251633 )
2017
24
Isolated polyhydramnios in the third trimester: is a gestational diabetes evaluation of value? ( 28488900 )
2017
25
Mode of delivery among women admitted with polyhydramnios. ( 28019126 )
2016
26
A Case of the TOF with APV Complicated with Polyhydramnios and Severe Bronchomalacia. ( 27579200 )
2016
27
Prenatal ultrasound factors and genetic disorders in pregnancies complicated by polyhydramnios. ( 27247190 )
2016
28
Pregnancy outcomes in severe polyhydramnios: no increase in risk in patients needing amnioreduction for maternal pain or respiratory distress. ( 26948899 )
2016
29
Pregnancy after oocyte donation in 45, X Turner syndrome women, complicated by gestational diabetes and polyhydramnios. Case report and mini-review of literature. ( 26942946 )
2016
30
Idiopathic polyhydramnios: persistence across gestation and impact on pregnancy outcomes. ( 26937648 )
2016
31
Rapid Resolution of Polyhydramnios Foretells Circulatory Collapse for the Donor Twin in Feto-Fetal Transfusion Syndrome. ( 26932285 )
2016
32
Polyhydramnios, Transient Antenatal Bartter's Syndrome, and MAGED2 Mutations. ( 27120771 )
2016
33
Idiopathic Polyhydramnios: Severity and Perinatal Morbidity. ( 26862725 )
2016
34
Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance. ( 26847765 )
2016
35
Polyhydramnios and cerebellar atrophy: a prenatal presentation of mitochondrial encephalomyopathy caused by mutations in the FBXL4 gene. ( 27099744 )
2016
36
Transient antenatal Bartter's Syndrome and X-linked polyhydramnios: insights from theA genetics of a rare condition. ( 27633862 )
2016
37
Molecular cytogenetic characterization of inv dup del(8p) in a fetus associated with ventriculomegaly, hypoplastic left heart, polyhydramnios and intestinal obstruction. ( 27343326 )
2016
38
Fetal hypothyroidism induced by maternal anti-TSH receptor blocking antibodies and complicated by polyhydramnios despite the absence of goiter. Treatment by intra-amniotic injections of levothyroxine. ( 27919402 )
2016
39
Idiopathic polyhydramnios at term and pregnancy outcomes: a multicenter observational study. ( 27625160 )
2016
40
Prevalence of a positive TORCH and parvovirus B19 screening in pregnancies complicated by polyhydramnios. ( 26970557 )
2016
41
QUESTION 1: Should the passage of a nasogastric tube be universal to all babies born to mothers with polyhydramnios or targeted to those with additional findings on ultrasound? ( 27540183 )
2016
42
Whole exome sequencing identifies the first STRADA point mutation in a patient with polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome (PMSE). ( 27170158 )
2016
43
Polyhydramnios in isolated oral cleft pregnancies: incidence and outcome in a retrospective study. ( 27943390 )
2016
44
EP21.17: Amnioreduction procedure for singleton pregnancies complicated by polyhydramnios causing maternal discomfort. ( 27647433 )
2016
45
Prenatal Diagnosis and Pregnancy Outcome Analysis of Polyhydramnios. ( 26720631 )
2016
46
Variable genetic penetrance of myotonic dystrophy following the diagnosis of idiopathic polyhydramnios. ( 27039051 )
2016
47
Foetal biometry in polyhydramnios: Does femur length fall behind? ( 26467094 )
2016
48
Can the Myocardial Performance Index Be Used as a New Predictive Factor for a Poor Prognosis in Fetuses With Idiopathic Polyhydramnios? ( 27821651 )
2016
49
Outcomes From Polyhydramnios With Normal Ultrasound. ( 26755694 )
2016
50
Intrapartum, postpartum characteristics and early neonatal outcomes of idiopathic polyhydramnios. ( 26926000 )
2016

Variations for Polyhydramnios

ClinVar genetic disease variations for Polyhydramnios:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 STRADA NM_001003787.2(STRADA): c.792T> A (p.Ser264Arg) single nucleotide variant Uncertain significance rs1057519011 GRCh37 Chromosome 17, 61784061: 61784061
2 STRADA NM_001003787.2(STRADA): c.792T> A (p.Ser264Arg) single nucleotide variant Uncertain significance rs1057519011 GRCh38 Chromosome 17, 63706701: 63706701
3 GLDN NM_181789.3(GLDN): c.1305G> A (p.Trp435Ter) single nucleotide variant Pathogenic/Likely pathogenic rs775011495 GRCh37 Chromosome 15, 51696600: 51696600
4 GLDN NM_181789.3(GLDN): c.1305G> A (p.Trp435Ter) single nucleotide variant Pathogenic/Likely pathogenic rs775011495 GRCh38 Chromosome 15, 51404403: 51404403
5 ABCC8 NM_000352.4(ABCC8): c.1024G> T (p.Gly342Trp) single nucleotide variant Likely pathogenic rs763028380 GRCh37 Chromosome 11, 17474818: 17474818
6 ABCC8 NM_000352.4(ABCC8): c.1024G> T (p.Gly342Trp) single nucleotide variant Likely pathogenic rs763028380 GRCh38 Chromosome 11, 17453271: 17453271

Expression for Polyhydramnios

Search GEO for disease gene expression data for Polyhydramnios.

Pathways for Polyhydramnios

Pathways related to Polyhydramnios according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.8 AQP3 DYNC2H1
2 10.58 STK11 STRADA
3 10.26 CLCNKB KCNJ1 SLC12A1

GO Terms for Polyhydramnios

Cellular components related to Polyhydramnios according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.4 AQP1 AQP3 CLCNKB CNTNAP1 DYNC2H1 FGFR3

Biological processes related to Polyhydramnios according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.78 AQP1 AQP3 CLCNKB SLC12A1
2 potassium ion transport GO:0006813 9.5 AQP1 KCNJ1 SLC12A1
3 potassium ion import across plasma membrane GO:1990573 9.49 KCNJ1 SLC12A1
4 potassium ion import GO:0010107 9.46 KCNJ1 SLC12A1
5 ion transmembrane transport GO:0034220 9.46 AQP1 CLCNKB KCNJ1 SLC12A1
6 odontogenesis GO:0042476 9.43 AQP1 AQP3
7 renal water homeostasis GO:0003091 9.4 AQP1 AQP3
8 cell volume homeostasis GO:0006884 9.37 AQP1 SLC12A1
9 water transport GO:0006833 9.26 AQP1 AQP3
10 glycerol transport GO:0015793 8.96 AQP1 AQP3
11 excretion GO:0007588 8.8 AQP3 CLCNKB KCNJ1

Molecular functions related to Polyhydramnios according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 channel activity GO:0015267 9.16 AQP1 AQP3
2 protein kinase activator activity GO:0030295 8.96 STK11 STRADA
3 water channel activity GO:0015250 8.62 AQP1 AQP3

Sources for Polyhydramnios

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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