Aliases & Classifications for Polyhydramnios

MalaCards integrated aliases for Polyhydramnios:

Name: Polyhydramnios 12 29 55 6 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:8488
ICD10 33 O40
ICD9CM 35 657 657.0
MeSH 44 D006831
NCIt 50 C92848
UMLS 73 C0020224

Summaries for Polyhydramnios

Disease Ontology : 12 A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac.

MalaCards based summary : Polyhydramnios is related to polyhydramnios, megalencephaly, and symptomatic epilepsy and bartter disease, and has symptoms including morning sickness An important gene associated with Polyhydramnios is STRADA (STE20-Related Kinase Adaptor Alpha), and among its related pathways/superpathways are LKB1 signaling events and Diuretics Pathway, Pharmacodynamics. The drugs Metformin and Glyburide have been mentioned in the context of this disorder. Affiliated tissues include placenta, lung and bone, and related phenotypes are Decreased human cytomegalovirus (HCMV) strain AD169 replication and Decreased substrate adherent cell growth

Wikipedia : 76 Polyhydramnios (polyhydramnion, hydramnios, polyhydramnios) is a medical condition describing an excess... more...

Related Diseases for Polyhydramnios

Diseases related to Polyhydramnios via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
# Related Disease Score Top Affiliating Genes
1 polyhydramnios, megalencephaly, and symptomatic epilepsy 34.4 STK11 STRADA
2 bartter disease 31.8 CLCNKB KCNJ1 SLC12A1
3 bartter syndrome, type 3 31.5 CLCNKB KCNJ1 SLC12A1
4 oligohydramnios 30.5 AFP AQP1 AQP3
5 antenatal bartter syndrome 29.9 KCNJ1 MAGED2 SLC12A1
6 chorioangioma 29.9 AFP FGFR3
7 diabetes insipidus, nephrogenic, autosomal 28.7 AQP1 AQP3 SLC12A1
8 polyhydramnios, chronic idiopathic 11.9
9 muscular hypertrophy-hepatomegaly-polyhydramnios syndrome 11.9
10 esophageal atresia 11.2
11 twin-to-twin transfusion syndrome 11.1
12 bartter syndrome, type 5, antenatal, transient 11.0
13 fetal akinesia syndrome, x-linked 10.9
14 chondrodysplasia, blomstrand type 10.9
15 pontocerebellar hypoplasia, type 4 10.9
16 bartter syndrome, type 2, antenatal 10.9
17 perlman syndrome 10.9
18 restrictive dermopathy, lethal 10.9
19 bartter syndrome, type 1, antenatal 10.9
20 lethal congenital contracture syndrome 7 10.9
21 bartter syndrome type 4 10.9
22 thanatophoric dysplasia, type ii 10.8
23 fetal akinesia deformation sequence 10.8
24 duodenal atresia 10.8
25 multiple pterygium syndrome, lethal type 10.8
26 spinal muscular atrophy, x-linked 2 10.8
27 megalencephaly-capillary malformation-polymicrogyria syndrome 10.8
28 bartter syndrome, type 4a, neonatal, with sensorineural deafness 10.8
29 bartter syndrome, type 4b, neonatal, with sensorineural deafness 10.8
30 nemaline myopathy 10 10.8
31 lethal congenital contracture syndrome 6 10.8
32 congenital chloride diarrhea 10.8
33 tracheal agenesis 10.8
34 placenta disease 10.2
35 dent disease 1 10.1 CLCNKB KCNJ1
36 renal tubular transport disease 10.1 CLCNKB KCNJ1 SLC12A1
37 dowling-degos disease 1 10.1 FGFR3 STK11
38 neonatal myasthenia gravis 10.1 AFP MUSK
39 gitelman syndrome 10.1 CLCNKB KCNJ1 SLC12A1
40 hypokalemia 10.0 CLCNKB KCNJ1 SLC12A1
41 nephrocalcinosis 10.0 CLCNKB KCNJ1 SLC12A1
42 hydrops fetalis, nonimmune, and/or atrial septal defect 10.0
43 myotonic dystrophy 10.0
44 fetal edema 10.0
45 hydrops fetalis 10.0
46 myotonia atrophica 10.0
47 mineral metabolism disease 9.9 CLCNKB KCNJ1
48 uterine anomalies 9.9 AFP STRADA
49 cervicitis 9.9
50 teratoma 9.9

Graphical network of the top 20 diseases related to Polyhydramnios:



Diseases related to Polyhydramnios

Symptoms & Phenotypes for Polyhydramnios

UMLS symptoms related to Polyhydramnios:


morning sickness

GenomeRNAi Phenotypes related to Polyhydramnios according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 9.26 MUSK STK11 STRADA FGFR3
2 Decreased substrate adherent cell growth GR00193-A-1 9.02 STK11 STRADA
3 Decreased substrate adherent cell growth GR00193-A-3 9.02 FGFR3 STK11 STRADA

MGI Mouse Phenotypes related to Polyhydramnios:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.14 GLDN AQP1 HSD17B4 KCNJ1 AQP3 MUSK
2 growth/size/body region MP:0005378 10.02 FGFR3 HSD17B4 AQP1 KCNJ1 AQP3 MUSK
3 homeostasis/metabolism MP:0005376 10.02 AFP HSD17B4 AQP1 KCNJ1 AQP3 MUSK
4 mortality/aging MP:0010768 10 AFP GLDN HSD17B4 AQP1 KCNJ1 AQP3
5 renal/urinary system MP:0005367 9.7 AQP1 KCNJ1 AQP3 CLCNKB SLC12A1 FGFR3
6 reproductive system MP:0005389 9.5 AFP HSD17B4 AQP1 CNTNAP1 SLC12A1 FGFR3
7 vision/eye MP:0005391 9.1 FGFR3 HSD17B4 AQP1 AQP3 CNTNAP1 STK11

Drugs & Therapeutics for Polyhydramnios

Drugs for Polyhydramnios (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 14219 4091
2
Glyburide Approved Phase 4 10238-21-8 3488
3 Hypoglycemic Agents Phase 4,Not Applicable
4 Acidophilus Nutraceutical Phase 3
5
Betamethasone Approved, Vet_approved Phase 1, Phase 2 378-44-9 9782
6 Betamethasone Valerate Phase 1, Phase 2 2152-44-5
7 glucocorticoids Phase 1, Phase 2
8 Respiratory System Agents Phase 1, Phase 2
9 Hormone Antagonists Phase 1, Phase 2
10 Hormones Phase 1, Phase 2
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
12 Anti-Asthmatic Agents Phase 1, Phase 2
13 Anti-Inflammatory Agents Phase 1, Phase 2
14 Betamethasone benzoate Phase 1, Phase 2
15 Betamethasone sodium phosphate Phase 1, Phase 2
16 Betamethasone-17,21-dipropionate Phase 1, Phase 2
17
Zinc Approved, Investigational Not Applicable 7440-66-6 23994
18
Insulin Detemir Approved Not Applicable 169148-63-4 5311023
19
Menthol Approved Not Applicable 2216-51-5 16666
20
leucovorin Approved, Nutraceutical 58-05-9 143 6006
21
Vitamin D Approved, Nutraceutical, Vet_approved Not Applicable 1406-16-2
22
Vitamin D3 Approved, Nutraceutical Not Applicable 67-97-0 6221 5280795
23
Ergocalciferol Approved, Nutraceutical Not Applicable 50-14-6 5280793
24
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
25 Micronutrients Not Applicable
26 Hematinics
27 Trace Elements Not Applicable
28 Vitamin B Complex
29 Ergocalciferols Not Applicable
30 Vitamins Not Applicable
31 Bone Density Conservation Agents Not Applicable
32 Calcium, Dietary Not Applicable
33 insulin Not Applicable
34 Pharmaceutical Solutions Not Applicable
35 Insulin, Isophane Not Applicable
36 Insulin, Long-Acting Not Applicable
37 Insulin, Short-Acting Not Applicable
38 Insulin, Globin Zinc Not Applicable
39 Isophane insulin, beef Not Applicable
40 Isophane Insulin, Human Not Applicable
41 Folate Nutraceutical
42 Vitamin B9 Nutraceutical
43 Vitamin D2 Nutraceutical Not Applicable
44 Calciferol Nutraceutical Not Applicable

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus Completed NCT01563120 Phase 4 metformin;glybenclamide
2 Probiotics (Lactobacillus Rhamnosus) in Reducing Glucose Intolerance During and After Pregnancy Unknown status NCT01436448 Phase 3 Probiotics Lactobacillus Rhamnosus
3 Syringe or Continuous Amnioreduction for Symptomatic Polyhydramnios. A Prospective Randomized Study. Completed NCT00236340 Phase 3
4 Tracheal Occlusion To Accelerate Lung Growth (TOTAL) Trial for Severe Pulmonary Hypoplasia Recruiting NCT01240057 Phase 2, Phase 3
5 The Safety, Tolerability And Metabolism Of GSK221149A, In Pregnant Women (30-36 Weeks), In Pre-Term Labor Completed NCT00404768 Phase 2 GSK221149A;Placebo
6 Prenatal Steroids for Treatment of Congenital Cystic Adenomatoid Malformations (CCAM) Terminated NCT00670956 Phase 1, Phase 2 Betamethasone;Placebo
7 Sonographic Assessment of Fetal Deglutition Associated With Hydramnion:Its Absence is Indicative of Central Nervous System (CNS) Pathology Unknown status NCT00687752
8 The Value of Prenatal Ultrasound in Complicated Twin Pregnancy and Its Correlation With Chromosomal Anomalies Unknown status NCT02732717
9 Vitamin D Treatment and Hypocalcemic Pregnant Women Unknown status NCT02021864 Not Applicable vitamin D3 50,000 unit;prenatal multivitamin
10 Myo-inositol, D-chiro-inositol, and D-chiro/Myo-inositol in Gestational Diabetes Unknown status NCT01762826
11 Studying Fetal Breathing Patterns Completed NCT00066976
12 Chewing Gums to Stimulate Intestinal Motility After Cesarean Section Completed NCT02386748 Not Applicable
13 Maternal and Perinatal Outcome in Women With History of Premature Labor in Previous Pregnancy Completed NCT01375439 Not Applicable
14 Improved Outcomes Associated With Inositol Dietary Supplementation in Women With Gestational Diabetes Mellitus Completed NCT01342874
15 Glycemic Control Using Insulin Levemir Versus Insulin NPH for Diabetes in Pregnancy Completed NCT01837680 Not Applicable Insulin
16 Real-time Continuous Glucose Monitoring Recruiting NCT03326232 Not Applicable
17 One Step Versus Two Step Approach for Gestational Diabetes Mellitus Screening Recruiting NCT03073330 Not Applicable
18 Pregnancy Outcomes and Medical Costs According to Gestational Diabetes Mellitus Diagnostic Criteria Recruiting NCT03421262 Not Applicable
19 Fetoscopic Endoluminal Tracheal Occlusion (FETO) for Congenital Diaphragm Hernia Recruiting NCT02596802 Not Applicable
20 Diabetes Mellitus With Pregnancy in Benisuef Localities Enrolling by invitation NCT03169205
21 Does Amniotic Fluid Index Affect the Fetal Cardiac Performance? Not yet recruiting NCT03277417
22 Is Vitamin D Insufficiency and Deficiency Associated With Antepartum and Postpartum Depression? Terminated NCT02272387 Not Applicable

Search NIH Clinical Center for Polyhydramnios

Cochrane evidence based reviews: polyhydramnios

Genetic Tests for Polyhydramnios

Genetic tests related to Polyhydramnios:

# Genetic test Affiliating Genes
1 Polyhydramnios 29

Anatomical Context for Polyhydramnios

MalaCards organs/tissues related to Polyhydramnios:

41
Placenta, Lung, Bone, Brain, Kidney, Heart, Fetal Lung

Publications for Polyhydramnios

Articles related to Polyhydramnios:

(show top 50) (show all 342)
# Title Authors Year
1
Targeted gene panel sequencing prenatally detects two novel mutations of DYNC2H1 in a fetus with increased biparietal diameter and polyhydramnios. ( 29359448 )
2018
2
A step towards precision medicine in management of severe transient polyhydramnios: MAGED2 variant. ( 29893154 )
2018
3
Placental abruption after amnioreduction for polyhydramnios caused by chorioangioma. ( 29507014 )
2018
4
Preterm Parturient with Polyhydramnios and Pancreatitis: Primary Presentation of Hyperparathyroidism. ( 29607233 )
2018
5
Fetal brain MRI in polyhydramnios: is it justified? ( 29865922 )
2018
6
Pregnant woman with polyhydramnios and fetus with small intestinal atresia. ( 28925193 )
2017
7
Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a thyroglobulin mutation. ( 28620499 )
2017
8
The relation between causes and onset time of polyhydramnios. ( 29714878 )
2017
9
Perinatal outcome in pregnancy with polyhydramnios in comparison with normal pregnancy in department of obstetrics at Shiraz University of Medical Sciences. ( 28462606 )
2017
10
Amount of polyhydramnios attributable to diabetes may be less than previously reported. ( 28138359 )
2017
11
Delivery outcomes of term pregnancy complicated by idiopathic polyhydramnios. ( 28643663 )
2017
12
Polyhydramnios or Excessive Fetal Growth Are Markers for Abnormal Perinatal Outcome in Euglycemic Pregnancies. ( 28838004 )
2017
13
Polyhydramnios - frequency of congenital anomalies in relation to the value of the amniotic fluid index. ( 28930371 )
2017
14
Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter? ( 29076544 )
2017
15
Polyhydramnios Affecting a Recipient-like Twin: Risk of Progression to Twin-Twin Transfusion Syndrome and Outcomes. ( 29287298 )
2017
16
Outcome of pregnancy in women diagnosed with idiopathic polyhydramnios. ( 28251633 )
2017
17
Isolated polyhydramnios in the third trimester: is a gestational diabetes evaluation of value?() ( 28488900 )
2017
18
Prenatal drainage of fetal urinoma with polyhydramnios: a case report and literature review. ( 28076981 )
2017
19
Mode of delivery among women admitted with polyhydramnios. ( 28019126 )
2016
20
A Case of the TOF with APV Complicated with Polyhydramnios and Severe Bronchomalacia. ( 27579200 )
2016
21
Prenatal ultrasound factors and genetic disorders in pregnancies complicated by polyhydramnios. ( 27247190 )
2016
22
Pregnancy outcomes in severe polyhydramnios: no increase in risk in patients needing amnioreduction for maternal pain or respiratory distress. ( 26948899 )
2016
23
Pregnancy after oocyte donation in 45, X Turner syndrome women, complicated by gestational diabetes and polyhydramnios. Case report and mini-review of literature. ( 26942946 )
2016
24
Idiopathic polyhydramnios: persistence across gestation and impact on pregnancy outcomes. ( 26937648 )
2016
25
Rapid Resolution of Polyhydramnios Foretells Circulatory Collapse for the Donor Twin in Feto-Fetal Transfusion Syndrome. ( 26932285 )
2016
26
Polyhydramnios, Transient Antenatal Bartter's Syndrome, and MAGED2 Mutations. ( 27120771 )
2016
27
Idiopathic Polyhydramnios: Severity and Perinatal Morbidity. ( 26862725 )
2016
28
Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance. ( 26847765 )
2016
29
Polyhydramnios and cerebellar atrophy: a prenatal presentation of mitochondrial encephalomyopathy caused by mutations in the FBXL4 gene. ( 27099744 )
2016
30
Transient antenatal Bartter's Syndrome and X-linked polyhydramnios: insights from theA genetics of a rare condition. ( 27633862 )
2016
31
Molecular cytogenetic characterization of inv dup del(8p) in a fetus associated with ventriculomegaly, hypoplastic left heart, polyhydramnios and intestinal obstruction. ( 27343326 )
2016
32
Fetal hypothyroidism induced by maternal anti-TSH receptor blocking antibodies and complicated by polyhydramnios despite the absence of goiter. Treatment by intra-amniotic injections of levothyroxine. ( 27919402 )
2016
33
Idiopathic polyhydramnios at term and pregnancy outcomes: a multicenter observational study. ( 27625160 )
2016
34
Prevalence of a positive TORCH and parvovirus B19 screening in pregnancies complicated by polyhydramnios. ( 26970557 )
2016
35
QUESTION 1: Should the passage of a nasogastric tube be universal to all babies born to mothers with polyhydramnios or targeted to those with additional findings on ultrasound? ( 27540183 )
2016
36
Whole exome sequencing identifies the first STRADA point mutation in a patient with polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome (PMSE). ( 27170158 )
2016
37
Polyhydramnios in isolated oral cleft pregnancies: incidence and outcome in a retrospective study. ( 27943390 )
2016
38
EP21.17: Amnioreduction procedure for singleton pregnancies complicated by polyhydramnios causing maternal discomfort. ( 27647433 )
2016
39
Prenatal Diagnosis and Pregnancy Outcome Analysis of Polyhydramnios. ( 26720631 )
2016
40
Variable genetic penetrance of myotonic dystrophy following the diagnosis of idiopathic polyhydramnios. ( 27039051 )
2016
41
Foetal biometry in polyhydramnios: Does femur length fall behind? ( 26467094 )
2016
42
Can the Myocardial Performance Index Be Used as a New Predictive Factor for a Poor Prognosis in Fetuses With Idiopathic Polyhydramnios? ( 27821651 )
2016
43
Outcomes From Polyhydramnios With Normal Ultrasound. ( 26755694 )
2016
44
Intrapartum, postpartum characteristics and early neonatal outcomes of idiopathic polyhydramnios. ( 26926000 )
2016
45
Hyperechogenic kidneys and polyhydramnios associated with HNF1B gene mutation. ( 27286685 )
2016
46
Questions about and speculations on the incidence of idiopathic polyhydramnios by fetal gender. ( 25786637 )
2015
47
Decreased umbilical orexin-A level is associated with idiopathic polyhydramnios. ( 25494826 )
2015
48
Association of isolated polyhydramnios at or beyond 34 weeks of gestation and pregnancy outcome. ( 25751210 )
2015
49
Reply to "Questions about and speculations on the incidence of idiopathic polyhydramnios by fetal gender". ( 25786638 )
2015
50
Polyhydramnios associated with Prader-Willi syndrome. ( 26271012 )
2015

Variations for Polyhydramnios

ClinVar genetic disease variations for Polyhydramnios:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 46;XX;t(10;15)(q25.2;q11.2) Translocation Pathogenic
2 STRADA NM_001003787.2(STRADA): c.792T> A (p.Ser264Arg) single nucleotide variant Uncertain significance rs1057519011 GRCh37 Chromosome 17, 61784061: 61784061
3 STRADA NM_001003787.2(STRADA): c.792T> A (p.Ser264Arg) single nucleotide variant Uncertain significance rs1057519011 GRCh38 Chromosome 17, 63706701: 63706701
4 GLDN NM_181789.3(GLDN): c.1305G> A (p.Trp435Ter) single nucleotide variant Pathogenic/Likely pathogenic rs775011495 GRCh37 Chromosome 15, 51696600: 51696600
5 GLDN NM_181789.3(GLDN): c.1305G> A (p.Trp435Ter) single nucleotide variant Pathogenic/Likely pathogenic rs775011495 GRCh38 Chromosome 15, 51404403: 51404403
6 ABCC8 NM_000352.4(ABCC8): c.1024G> T (p.Gly342Trp) single nucleotide variant Likely pathogenic rs763028380 GRCh37 Chromosome 11, 17474818: 17474818
7 ABCC8 NM_000352.4(ABCC8): c.1024G> T (p.Gly342Trp) single nucleotide variant Likely pathogenic rs763028380 GRCh38 Chromosome 11, 17453271: 17453271

Expression for Polyhydramnios

Search GEO for disease gene expression data for Polyhydramnios.

Pathways for Polyhydramnios

Pathways related to Polyhydramnios according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.58 STK11 STRADA
2 10.26 CLCNKB KCNJ1 SLC12A1

GO Terms for Polyhydramnios

Cellular components related to Polyhydramnios according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.4 AQP1 AQP3 CLCNKB CNTNAP1 FGFR3 GLDN

Biological processes related to Polyhydramnios according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein autophosphorylation GO:0046777 9.61 FGFR3 MUSK STK11
2 potassium ion transport GO:0006813 9.58 AQP1 KCNJ1 SLC12A1
3 potassium ion transmembrane transport GO:0071805 9.54 AQP1 KCNJ1 SLC12A1
4 potassium ion import GO:0010107 9.49 KCNJ1 SLC12A1
5 odontogenesis GO:0042476 9.48 AQP1 AQP3
6 renal water homeostasis GO:0003091 9.46 AQP1 AQP3
7 ion transmembrane transport GO:0034220 9.46 AQP1 CLCNKB KCNJ1 SLC12A1
8 water transport GO:0006833 9.32 AQP1 AQP3
9 cell volume homeostasis GO:0006884 9.26 AQP1 SLC12A1
10 glycerol transport GO:0015793 8.96 AQP1 AQP3
11 excretion GO:0007588 8.8 AQP3 CLCNKB KCNJ1

Molecular functions related to Polyhydramnios according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.56 FGFR3 MUSK STK11 STRADA
2 channel activity GO:0015267 9.16 AQP1 AQP3
3 protein kinase activator activity GO:0030295 8.96 STK11 STRADA
4 water channel activity GO:0015250 8.62 AQP1 AQP3

Sources for Polyhydramnios

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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