Aliases & Classifications for Polyhydramnios

MalaCards integrated aliases for Polyhydramnios:

Name: Polyhydramnios 12 29 54 6 43 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:8488
ICD9CM 34 657 657.0
MeSH 43 D006831
NCIt 49 C92848
SNOMED-CT 67 86203003
ICD10 32 O40
UMLS 71 C0020224

Summaries for Polyhydramnios

Disease Ontology : 12 A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac.

MalaCards based summary : Polyhydramnios is related to polyhydramnios, megalencephaly, and symptomatic epilepsy and bartter disease, and has symptoms including morning sickness An important gene associated with Polyhydramnios is MTM1 (Myotubularin 1), and among its related pathways/superpathways is Diuretics Pathway, Pharmacodynamics. The drugs Metformin and Glyburide have been mentioned in the context of this disorder. Affiliated tissues include placenta, lung and heart, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 74 Polyhydramnios is a medical condition describing an excess of amniotic fluid in the amniotic sac. It is... more...

Related Diseases for Polyhydramnios

Diseases related to Polyhydramnios via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 279)
# Related Disease Score Top Affiliating Genes
1 polyhydramnios, megalencephaly, and symptomatic epilepsy 35.0 STRADA STK11
2 bartter disease 33.2 SLC12A1 MAGED2 KCNJ1 CLCNKB
3 oligohydramnios 32.8 AQP9 AQP8 AQP3 AFP
4 bartter syndrome, type 1, antenatal 32.6 SLC12A1 KCNJ1
5 bartter syndrome, type 2, antenatal 32.6 SLC12A1 KCNJ1
6 bartter syndrome, type 3 32.6 SLC12A1 KCNJ1 CLCNKB
7 fetal akinesia deformation sequence 1 32.4 RAPSN MUSK DOK7 CNTNAP1
8 bartter syndrome, type 4a, neonatal, with sensorineural deafness 32.3 KCNJ1 CLCNKB
9 diabetes insipidus 30.7 SLC12A1 CLCNKB AQP3 AFP
10 antenatal bartter syndrome 30.7 SLC12A1 MAGED2 KCNJ1
11 placenta disease 30.6 SLC12A1 KCNJ1 AFP
12 muscular disease 30.4 RAPSN MUSK MTM1 LMOD3 DOK7
13 diabetes insipidus, nephrogenic, autosomal 30.3 SLC12A1 KCNJ1 CLCNKB CFAP47 AQP8 AQP3
14 nephrocalcinosis 29.9 SLC12A1 KCNJ1 CLCNKB
15 polyhydramnios, chronic idiopathic 12.3
16 muscular hypertrophy-hepatomegaly-polyhydramnios syndrome 12.2
17 bartter syndrome, type 5, antenatal, transient 11.6
18 fetal akinesia syndrome, x-linked 11.6
19 esophageal atresia 11.5
20 twin-to-twin transfusion syndrome 11.4
21 duodenal atresia 11.4
22 kagami-ogata syndrome 11.4
23 perlman syndrome 11.3
24 chondrodysplasia, blomstrand type 11.2
25 pontocerebellar hypoplasia, type 4 11.2
26 restrictive dermopathy, lethal 11.2
27 lethal congenital contracture syndrome 7 11.2
28 bartter syndrome type 4 11.2
29 caffey disease 11.0
30 thanatophoric dysplasia, type ii 11.0
31 glycogen storage disease iv 11.0
32 multiple pterygium syndrome, lethal type 11.0
33 spinal muscular atrophy, x-linked 2 11.0
34 hydrocephalus, endocardial fibroelastosis, and cataracts 11.0
35 megalencephaly-capillary malformation-polymicrogyria syndrome 11.0
36 bartter syndrome, type 4b, neonatal, with sensorineural deafness 11.0
37 nemaline myopathy 10 11.0
38 lethal congenital contracture syndrome 6 11.0
39 fetal akinesia deformation sequence 2 11.0
40 fetal akinesia deformation sequence 3 11.0
41 fetal akinesia deformation sequence 4 11.0
42 congenital chloride diarrhea 11.0
43 arterial calcification of infancy 11.0
44 bamforth syndrome 11.0
45 tracheal agenesis 11.0
46 postsynaptic congenital myasthenic syndromes 10.6 RAPSN MUSK DOK7
47 cenani-lenz syndactyly syndrome 10.6 RAPSN MUSK DOK7
48 hypomagnesemia 5, renal, with or without ocular involvement 10.6 SLC12A1 KCNJ1
49 protoporphyria, erythropoietic, 1 10.6 RAPSN MUSK DOK7
50 hydrarthrosis 10.6 AQP9 AQP3

Graphical network of the top 20 diseases related to Polyhydramnios:



Diseases related to Polyhydramnios

Symptoms & Phenotypes for Polyhydramnios

UMLS symptoms related to Polyhydramnios:


morning sickness

MGI Mouse Phenotypes related to Polyhydramnios:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.18 AFP AQP3 AQP9 CNTNAP1 DOK7 GLDN
2 homeostasis/metabolism MP:0005376 10.1 AFP AQP3 AQP8 AQP9 CLCNKB KCNJ1
3 mortality/aging MP:0010768 10.07 AFP AQP3 CNTNAP1 DOK7 DYNC2H1 GLDN
4 muscle MP:0005369 9.76 CNTNAP1 DOK7 KCNQ1 LMOD3 MTM1 MUSK
5 renal/urinary system MP:0005367 9.5 AQP3 AQP8 CLCNKB DYNC2H1 KCNJ1 SLC12A1
6 respiratory system MP:0005388 9.17 AQP3 DOK7 DYNC2H1 MTM1 MUSK RAPSN

Drugs & Therapeutics for Polyhydramnios

Drugs for Polyhydramnios (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 14219 4091
2
Glyburide Approved Phase 4 10238-21-8 3488
3 Hypoglycemic Agents Phase 4
4
Oxytocin Approved, Vet_approved Phase 3 50-56-6 439302 53477758
5
Misoprostol Approved Phase 3 59122-46-2 5282381
6
Carbetocin Approved, Investigational Phase 3 37025-55-1 71715 16681432
7 Oxytocics Phase 3
8 Gastrointestinal Agents Phase 3
9 Anti-Ulcer Agents Phase 3
10 Antacids Phase 3
11
Tranexamic Acid Approved Phase 1, Phase 2 1197-18-8 5526
12
Betamethasone Approved, Vet_approved Phase 1, Phase 2 378-44-9 9782
13 Hemostatics Phase 1, Phase 2
14 Antifibrinolytic Agents Phase 1, Phase 2
15 Coagulants Phase 1, Phase 2
16 Hormones Phase 1, Phase 2
17 Anti-Asthmatic Agents Phase 1, Phase 2
18 Respiratory System Agents Phase 1, Phase 2
19 Hormone Antagonists Phase 1, Phase 2
20 Betamethasone benzoate Phase 1, Phase 2
21 Betamethasone sodium phosphate Phase 1, Phase 2
22 Anti-Inflammatory Agents Phase 1, Phase 2
23 Betamethasone Valerate Phase 1, Phase 2 2152-44-5
24 Betamethasone-17,21-dipropionate Phase 1, Phase 2
25 glucocorticoids Phase 1, Phase 2
26
Propranolol Approved, Investigational 525-66-6 4946
27
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
28
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
29
Calcium Approved, Nutraceutical 7440-70-2 271
30
Vitamin D3 Approved, Nutraceutical 67-97-0 6221 5280795
31
Pomegranate Experimental, Investigational
32 Micronutrients
33 Trace Elements
34 Nutrients
35 Ergocalciferols
36 Vitamin D2
37 Calcium, Dietary
38 Calciferol
39 Vitamins
40 Pharmaceutical Solutions
41 Neurotransmitter Agents
42 Antihypertensive Agents
43 Anti-Arrhythmia Agents
44 Adrenergic Antagonists
45 Adrenergic beta-Antagonists
46 Vasodilator Agents
47 Adrenergic Agents
48 Anesthetics
49 Central Nervous System Depressants

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus Completed NCT01563120 Phase 4 metformin;glybenclamide
2 Syringe or Continuous Amnioreduction for Symptomatic Polyhydramnios. A Prospective Randomized Study. Completed NCT00236340 Phase 3
3 Carbetocin in Preventing Postpartum Bleeding in Women With Severe Preeclampsia. Completed NCT02086994 Phase 3 misoprostol;carbetocin
4 Randomized Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) Versus Expectant Management During Pregnancy in Fetuses With Left Sided and Isolated Congenital Diaphragma Hernia and Severe Pulmonary Hypoplasia. Recruiting NCT01240057 Phase 2, Phase 3
5 Prevention of Pre-Term Birth by Treatment of Periodontal Disease During Pregnancy - The Smile Study Unknown status NCT00133926 Phase 2
6 Efficacy of Tranexamic Acid in Reducing Blood Loss During and After Caesarean Section Unknown status NCT02350179 Phase 1, Phase 2 Tranexamic Acid;Glucose
7 Investigation of Prenatal Steroids for Treatment of Prenatally Diagnosed CCAMs Terminated NCT00670956 Phase 1, Phase 2 Betamethasone;Placebo
8 Does the Amniotic Fluid Index Affect the Fetal Cardiac Performance? Unknown status NCT03277417
9 Effect of Treatment of Vitamin D Deficiency During Pregnancy on Hypocalcemia Unknown status NCT02021864 vitamin D3 50,000 unit;prenatal multivitamin
10 Sonographic Assessment of Fetal Deglutition Associated With Hydramnion:Its Absence is Indicative of CNS Pathology? a Report on Two Cases. Unknown status NCT00687752
11 The Value of Prenatal Ultrasound in the Diagnosis and Monitoring of Complicated Twin Pregnancy and Its Correlation With Chromosomal Anomalies of Twin Unknown status NCT02732717
12 Pomegranate to Reduce Maternal and Fetal Oxidative Stress and Improve Outcome in Pregnancies Complicated With Preterm Premature Rupture of the Membranes Unknown status NCT01584323
13 Efficacy and Efficiency of Uterocervical Angle for Prediction of Preterm Labor in Patients With Idiopathic Polyhydramnios: a Prospective Cohort Study Completed NCT03828695
14 Classification of Fetal Breathing Patterns in the Maturing Upper Airway: Spectral Waveform Analysis of Amniotic Fluid Flow Dynamics in Normal Development, Polyhydramnios, and Oligohydramnios Completed NCT00066976
15 Continuous Glucose Monitoring in Women With Type 1 Diabetes in Pregnancy Trial Completed NCT01788527
16 Maternal and Perinatal Outcome in Women With History of Premature Labor in Previous Pregnancy and Submitted to Active Search of Genital Infection Completed NCT01375439
17 Chewing Gums to Stimulate Intestinal Motility After Cesarean Section: A Randomized Controlled Trial Completed NCT02386748
18 Effect of Adjunctive Misoprostol on Blood Loss at Vaginal Delivery Completed NCT02411916
19 Effects of Co-administered Oxytocin and Intravenous Tranexamic Acid on Prevention of Postpartum Hemorrhage in Pregnant Women With Twin Pregnancy Undergoing Elective Cesarean Section: A Double-Blind Randomized Clinical Trial Recruiting NCT03778242 oxytocin;TA;placebo to TA
20 Effects of Co-administered Sublingual Misoprostol and Intravenous Tranexamic Acid on Prevention of Postpartum Hemorrhage in Pregnant Women With Twin Pregnancy Undergoing Elective Cesarean Section: A Double-Blind Randomized Clinical Trial Recruiting NCT03774524 Misoprostol;TA;placebo to misoprostol;placebo to TA
21 The Effect of Carbetocin Versus Oral Tranexamic Acid Plus, Buccal Misoprostol on Blood Loss After Vaginal Delivery: a Randomized Controlled Trial Recruiting NCT03708497 carbetocin;Tranexamic acid plus misoprostol;misoprostol
22 Feto-Fetal Transfusion Syndrome in Multiple Pregnancies Recruiting NCT04148859
23 A Comparison Between the Effect of Oxytocin Only and Oxytocin Plus Propranolol on Induction of Labor in Term Pregnancy Recruiting NCT03533699 Propranolol;Placebo Oral Tablet
24 Colloid Preload Versus Crystalloid Co-load in Cesarean Section Under Spinal Anesthesia Randomized Controlled Trial Terminated NCT03107598 colloid preload
25 Pilot Study-A Cost and Time Savings Comparison of Lamellar Body Count and FLM II Withdrawn NCT00613977

Search NIH Clinical Center for Polyhydramnios

Cochrane evidence based reviews: polyhydramnios

Genetic Tests for Polyhydramnios

Genetic tests related to Polyhydramnios:

# Genetic test Affiliating Genes
1 Polyhydramnios 29

Anatomical Context for Polyhydramnios

MalaCards organs/tissues related to Polyhydramnios:

40
Placenta, Lung, Heart, Kidney, Testes, Thyroid, Brain

Publications for Polyhydramnios

Articles related to Polyhydramnios:

(show top 50) (show all 2342)
# Title Authors PMID Year
1
Phenotype-genotype correlation in antenatal and neonatal variants of Bartter syndrome. 54 61
19096086 2009
2
Steady-state levels of aquaporin 1 mRNA expression are increased in idiopathic polyhydramnios. 54 61
16522429 2006
3
Prenatal findings in epidermolysis bullosa with pyloric atresia in a family not known to be at risk. 54 61
15912478 2005
4
A novel model of polyhydramnios: amniotic fluid volume is increased in aquaporin 1 knockout mice. 54 61
15970890 2005
5
The importance of investigating for uniparental disomy in prenatally identified balanced acrocentric rearrangements. 54 61
11857621 2002
6
Prenatal diagnosis of thanatophoric dysplasia by mutational analysis of the fibroblast growth factor receptor 3 gene and a proposed correction of previously published PCR results. 54 61
10073901 1999
7
Open neural tube defects: immunocytochemical demonstration of neuroepithelial cells in amniotic fluid. 54 61
9067106 1997
8
The effect of increased amnion volume severity on fetal Doppler indices and perinatal outcomes in idiopathic polyhydramnios. 61
30081701 2020
9
The influence of different inositol stereoisomers supplementation in pregnancy on maternal gestational diabetes mellitus and fetal outcomes in high-risk patients: a randomized controlled trial. 61
30558466 2020
10
Tracheal agenesis with esophageal atresia: an autopsy case report of a variant incompatible with life. 61
31314628 2020
11
Single-Center Outcome of Fetoscopic Tracheal Balloon Occlusion for Severe Congenital Diaphragmatic Hernia. 61
32028493 2020
12
Value of routine ultrasound examination at 35-37 weeks' gestation in diagnosis of non-cephalic presentation. 61
31671470 2020
13
Accuracy of the Ultrasound Estimate of the Amniotic Fluid Volume (Amniotic Fluid Index and Single Deepest Pocket) to Identify Actual Low, Normal, and High Amniotic Fluid Volumes as Determined by Quantile Regression. 61
31423632 2020
14
[Postnatal outcome from polyhydramnios without sonographic abnormalities]. 61
31785376 2020
15
Kagami-Ogata syndrome: an important differential diagnosis to Beckwith-Wiedemann syndrome. 61
31994200 2020
16
Biallelic loss of function variants in ATP1A2 cause hydrops fetalis, microcephaly, arthrogryposis and extensive cortical malformations. 61
30690204 2020
17
Reproductive health issues in female patients with beta-thalassaemia major: a narrative literature review. 61
31999213 2020
18
Prenatal and perinatal history in Kabuki Syndrome. 61
31654559 2020
19
Perinatal features of Prader-Willi syndrome: a Chinese cohort of 134 patients. 61
31964399 2020
20
GATAD2B-associated neurodevelopmental disorder (GAND): clinical and molecular insights into a NuRD-related disorder. 61
31949314 2020
21
Congenital Myotonic Dystrophy and Brugada Syndrome: A Report of Two Cases. 61
31915326 2020
22
Acute Kidney Injury is Associated with Poor Lung Outcomes in Infants Born ≥32 Weeks of Gestational Age. 61
31739364 2020
23
Non-invasive fetal electrocardiography ameliorates fetal outcome in chorioangioma: A case report. 61
32007964 2020
24
Understanding Factors Leading to Primary Cesarean Section and Vaginal Birth After Cesarean Delivery in the Friuli-Venezia Giulia Region (North-Eastern Italy), 2005-2015. 61
31941963 2020
25
Adherence to postpartum diabetes mellitus screening, do associated pregnancy complications make a difference? 61
31805350 2020
26
Updating the amniotic fluid index nomograms according to perinatal outcome. 61
30021504 2020
27
Antepartum and intrapartum risk factors for neonatal hypoxic-ischemic encephalopathy: a systematic review with meta-analysis. 61
31567446 2019
28
Host and viral mechanisms of congenital Zika syndrome. 61
31451049 2019
29
Inherited salt-losing tubulopathy: an old condition but a new category of tubulopathy. 61
31830341 2019
30
Cantú syndrome: Findings from 74 patients in the International Cantú Syndrome Registry. 61
31828977 2019
31
[Kagami-Ogata Syndrome: An Anomaly of the Ribs as a Pathognomonic Feature for the Clinical Diagnosis of an (epi)Genetic Syndrome]. 61
31853915 2019
32
The association between pregnancies complicated with isolated polyhydramnios or oligohydramnios and offspring long-term gastrointestinal morbidity. 61
31642947 2019
33
Prenatal exposure to isolated amniotic fluid disorders and the risk for long-term cardiovascular morbidity in the offspring. 61
31876194 2019
34
Oral glucose tolerance test for suspected late onset gestational diabetes. 61
31851555 2019
35
Risk factors for reduced fetal movements in pregnancy: A systematic review and meta-analysis. 61
31677496 2019
36
Effect of intra-amniotic fluid pressure from polyhydramnios on cervical length in patients with twin-twin transfusion syndrome undergoing fetoscopic laser surgery. 61
30693576 2019
37
Ex utero intrapartum treatment (EXIT) for fetal neck masses: A tertiary center experience and literature review. 61
31479918 2019
38
Transient Isolated Polyhydramnios and Perinatal Outcomes. 61
30253428 2019
39
Fetal brain MRI in polyhydramnios: is it justified? 61
29865922 2019
40
Single-nucleotide polymorphism-based chromosomal microarray analysis provides clues and insights into disease mechanisms. 61
30693591 2019
41
Outcome of Pregnancies Diagnosed with TRAP Sequence Prenatally: A Single-Centre Experience. 61
31770756 2019
42
Congenital Chylothorax: Common and Uncommon Findings in an Infant with Chylous Effusions. 61
31712400 2019
43
Kagami-Ogata syndrome in a fetus presenting with polyhydramnios, malformations, and preterm delivery: a case report. 61
31753000 2019
44
Novel solute carrier family 26, member 3 mutation in a prenatal recurrent case with congenital chloride diarrhea. 61
31499577 2019
45
The association between polyhydramnios and CMV infection - retrospective cohort study. 61
31698981 2019
46
Predicting poor outcomes and the need for surgical treatment in neonates with meconium peritonitis. 61
31713898 2019
47
Incidence of gastro-intestinal anomalies and surgical outcome of fetuses diagnosed with echogenic bowel and bowel dilatation. 61
31461799 2019
48
A case of amniotic fluid embolism successfully treated by multidisciplinary treatment. 61
32026080 2019
49
Perinatal complications and live-birth outcomes following assisted reproductive technology: a retrospective cohort study. 61
31634242 2019
50
The utility of next generation sequencing in the correct diagnosis of congenital hypochloremic hypokalemic metabolic alkalosis. 61
31325522 2019

Variations for Polyhydramnios

ClinVar genetic disease variations for Polyhydramnios:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 46;XX;t(10;15)(q25.2;q11.2)Translocation Pathogenic 267923
2 MTM1 NM_000252.2(MTM1):c.1262G>T (p.Arg421Leu)SNV Pathogenic 599006 rs587783772 X:149828138-149828138 X:150659665-150659665
3 KCNQ1 NM_181798.1(KCNQ1):c.704A>G (p.Lys235Arg)SNV Pathogenic/Likely pathogenic 52953 rs12720458 11:2606494-2606494 11:2585264-2585264
4 GLDN NM_181789.4(GLDN):c.1305G>A (p.Trp435Ter)SNV Pathogenic/Likely pathogenic 488521 rs775011495 15:51696600-51696600 15:51404403-51404403
5 ABCC8 NM_001287174.2(ABCC8):c.1024G>T (p.Gly342Trp)SNV Likely pathogenic 523360 rs763028380 11:17474818-17474818 11:17453271-17453271
6 STRADA NM_001003787.4(STRADA):c.792T>A (p.Ser264Arg)SNV Uncertain significance 374250 rs1057519011 17:61784061-61784061 17:63706701-63706701

Expression for Polyhydramnios

Search GEO for disease gene expression data for Polyhydramnios.

Pathways for Polyhydramnios

Pathways related to Polyhydramnios according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.26 SLC12A1 KCNJ1 CLCNKB

GO Terms for Polyhydramnios

Cellular components related to Polyhydramnios according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.77 SLC12A1 RAPSN MUSK MTM1 KCNQ1 KCNJ1
2 membrane GO:0016020 9.55 STK11 SLC12A1 RAPSN MUSK MTM1 MAGED2

Biological processes related to Polyhydramnios according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.63 SLC12A1 KCNQ1 CLCNKB AQP9 AQP8 AQP3
2 potassium ion transport GO:0006813 9.58 SLC12A1 KCNQ1 KCNJ1
3 cellular response to cAMP GO:0071320 9.43 KCNQ1 AQP9 AQP8
4 urea transmembrane transport GO:0071918 9.37 AQP9 AQP3
5 glycerol transport GO:0015793 9.32 AQP9 AQP3
6 excretion GO:0007588 9.13 KCNJ1 CLCNKB AQP9
7 water transport GO:0006833 8.8 AQP9 AQP8 AQP3

Molecular functions related to Polyhydramnios according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase activator activity GO:0030295 9.32 STRADA STK11
2 urea transmembrane transporter activity GO:0015204 9.26 AQP9 AQP3
3 glycerol channel activity GO:0015254 9.16 AQP9 AQP3
4 channel activity GO:0015267 9.13 AQP9 AQP8 AQP3
5 water channel activity GO:0015250 8.8 AQP9 AQP8 AQP3

Sources for Polyhydramnios

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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