Aliases & Classifications for Polyhydramnios

MalaCards integrated aliases for Polyhydramnios:

Name: Polyhydramnios 12 29 54 6 43 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:8488
ICD9CM 34 657.0
MeSH 43 D006831
NCIt 49 C92848
SNOMED-CT 67 86203003
ICD10 32 O40
UMLS 71 C0020224

Summaries for Polyhydramnios

Disease Ontology : 12 A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac.

MalaCards based summary : Polyhydramnios is related to polyhydramnios, megalencephaly, and symptomatic epilepsy and bartter disease, and has symptoms including morning sickness An important gene associated with Polyhydramnios is MTM1 (Myotubularin 1), and among its related pathways/superpathways is Diuretics Pathway, Pharmacodynamics. The drugs Metformin and Glyburide have been mentioned in the context of this disorder. Affiliated tissues include placenta, lung and testes, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 74 Polyhydramnios is a medical condition describing an excess of amniotic fluid in the amniotic sac. It is... more...

Related Diseases for Polyhydramnios

Diseases related to Polyhydramnios via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 284)
# Related Disease Score Top Affiliating Genes
1 polyhydramnios, megalencephaly, and symptomatic epilepsy 35.0 STRADA STK11
2 bartter disease 33.2 SLC12A1 MAGED2 KCNJ1 CLCNKB
3 oligohydramnios 32.9 AQP9 AQP8 AQP3 AFP
4 bartter syndrome, type 1, antenatal 32.6 SLC12A1 KCNJ1
5 bartter syndrome, type 3 32.6 SLC12A1 KCNJ1 CLCNKB
6 bartter syndrome, type 2, antenatal 32.6 SLC12A1 KCNJ1
7 fetal akinesia deformation sequence 1 32.4 RAPSN MUSK DOK7 CNTNAP1
8 bartter syndrome, type 4a, neonatal, with sensorineural deafness 32.3 KCNJ1 CLCNKB
9 diabetes insipidus 30.7 SLC12A1 CLCNKB AQP3 AFP
10 antenatal bartter syndrome 30.7 SLC12A1 MAGED2 KCNJ1
11 placenta disease 30.6 SLC12A1 KCNJ1 AFP
12 myasthenia gravis 30.4 RAPSN MUSK DOK7
13 diabetes insipidus, nephrogenic, autosomal 30.3 SLC12A1 KCNJ1 CLCNKB CFAP47 AQP8 AQP3
14 nephrocalcinosis 29.7 SLC12A1 KCNJ1 CLCNKB
15 polyhydramnios, chronic idiopathic 12.3
16 muscular hypertrophy-hepatomegaly-polyhydramnios syndrome 12.2
17 bartter syndrome, type 5, antenatal, transient 11.6
18 fetal akinesia syndrome, x-linked 11.6
19 esophageal atresia 11.5
20 kagami-ogata syndrome 11.5
21 twin-to-twin transfusion syndrome 11.4
22 duodenal atresia 11.4
23 perlman syndrome 11.3
24 chondrodysplasia, blomstrand type 11.2
25 pontocerebellar hypoplasia, type 4 11.2
26 restrictive dermopathy, lethal 11.2
27 lethal congenital contracture syndrome 7 11.2
28 bartter syndrome type 4 11.2
29 caffey disease 11.1
30 thanatophoric dysplasia, type ii 11.1
31 glycogen storage disease iv 11.1
32 multiple pterygium syndrome, lethal type 11.1
33 spinal muscular atrophy, x-linked 2 11.1
34 hydrocephalus, endocardial fibroelastosis, and cataracts 11.1
35 megalencephaly-capillary malformation-polymicrogyria syndrome 11.1
36 myopathy, congenital, compton-north 11.1
37 bartter syndrome, type 4b, neonatal, with sensorineural deafness 11.1
38 nemaline myopathy 10 11.1
39 lethal congenital contracture syndrome 6 11.1
40 fetal akinesia deformation sequence 2 11.1
41 fetal akinesia deformation sequence 3 11.1
42 fetal akinesia deformation sequence 4 11.1
43 congenital chloride diarrhea 11.1
44 arterial calcification of infancy 11.1
45 bamforth syndrome 11.1
46 tracheal agenesis 11.1
47 postsynaptic congenital myasthenic syndromes 10.6 RAPSN MUSK DOK7
48 cenani-lenz syndactyly syndrome 10.6 RAPSN MUSK DOK7
49 hypomagnesemia 5, renal, with or without ocular involvement 10.6 SLC12A1 KCNJ1
50 protoporphyria, erythropoietic, 1 10.6 RAPSN MUSK DOK7

Graphical network of the top 20 diseases related to Polyhydramnios:



Diseases related to Polyhydramnios

Symptoms & Phenotypes for Polyhydramnios

UMLS symptoms related to Polyhydramnios:


morning sickness

MGI Mouse Phenotypes related to Polyhydramnios:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.13 AFP AQP3 AQP9 CNTNAP1 DOK7 GLDN
2 homeostasis/metabolism MP:0005376 10.07 AFP AQP3 AQP8 AQP9 CLCNKB KCNJ1
3 muscle MP:0005369 9.76 CNTNAP1 DOK7 KCNQ1 LMOD3 MTM1 MUSK
4 renal/urinary system MP:0005367 9.5 AQP3 AQP8 CLCNKB DYNC2H1 KCNJ1 SLC12A1
5 respiratory system MP:0005388 9.17 AQP3 DOK7 DYNC2H1 MTM1 MUSK RAPSN

Drugs & Therapeutics for Polyhydramnios

Drugs for Polyhydramnios (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 14219 4091
2
Glyburide Approved Phase 4 10238-21-8 3488
3 Hypoglycemic Agents Phase 4
4
Misoprostol Approved Phase 3 59122-46-2 5282381
5
Carbetocin Approved, Investigational Phase 3 37025-55-1 71715 16681432
6 Antacids Phase 3
7 Anti-Ulcer Agents Phase 3
8 Gastrointestinal Agents Phase 3
9
Tranexamic Acid Approved Phase 1, Phase 2 1197-18-8 5526
10
Betamethasone Approved, Vet_approved Phase 1, Phase 2 378-44-9 9782
11 Hemostatics Phase 1, Phase 2
12 Antifibrinolytic Agents Phase 1, Phase 2
13 Coagulants Phase 1, Phase 2
14 Hormones Phase 1, Phase 2
15 Respiratory System Agents Phase 1, Phase 2
16 Anti-Asthmatic Agents Phase 1, Phase 2
17 glucocorticoids Phase 1, Phase 2
18 Hormone Antagonists Phase 1, Phase 2
19 Anti-Inflammatory Agents Phase 1, Phase 2
20
Oxytocin Approved, Vet_approved 50-56-6 53477758 439302
21
Propranolol Approved, Investigational 525-66-6 4946
22
Vitamin D3 Approved, Nutraceutical 67-97-0 5280795 6221
23
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
24
Pomegranate Experimental, Investigational
25 Trace Elements
26 Vitamins
27 Micronutrients
28 Nutrients
29 Calcium, Dietary
30 Calciferol
31 Pharmaceutical Solutions
32 Adrenergic beta-Antagonists
33 Antihypertensive Agents
34 Adrenergic Agents
35 Adrenergic Antagonists
36 Anti-Arrhythmia Agents
37 Vasodilator Agents
38 Neurotransmitter Agents
39 Anesthetics
40
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus Completed NCT01563120 Phase 4 metformin;glybenclamide
2 Syringe or Continuous Amnioreduction for Symptomatic Polyhydramnios. A Prospective Randomized Study. Completed NCT00236340 Phase 3
3 Carbetocin in Preventing Postpartum Bleeding in Women With Severe Preeclampsia. Completed NCT02086994 Phase 3 misoprostol;carbetocin
4 Randomized Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) Versus Expectant Management During Pregnancy in Fetuses With Left Sided and Isolated Congenital Diaphragma Hernia and Severe Pulmonary Hypoplasia. Active, not recruiting NCT01240057 Phase 2, Phase 3
5 Efficacy of Tranexamic Acid in Reducing Blood Loss During and After Caesarean Section Unknown status NCT02350179 Phase 1, Phase 2 Tranexamic Acid;Glucose
6 Prevention of Pre-Term Birth by Treatment of Periodontal Disease During Pregnancy - The Smile Study Unknown status NCT00133926 Phase 2
7 Investigation of Prenatal Steroids for Treatment of Prenatally Diagnosed CCAMs Terminated NCT00670956 Phase 1, Phase 2 Betamethasone;Placebo
8 Does the Amniotic Fluid Index Affect the Fetal Cardiac Performance? Unknown status NCT03277417
9 Effect of Treatment of Vitamin D Deficiency During Pregnancy on Hypocalcemia Unknown status NCT02021864 vitamin D3 50,000 unit;prenatal multivitamin
10 Sonographic Assessment of Fetal Deglutition Associated With Hydramnion:Its Absence is Indicative of CNS Pathology? a Report on Two Cases. Unknown status NCT00687752
11 The Value of Prenatal Ultrasound in the Diagnosis and Monitoring of Complicated Twin Pregnancy and Its Correlation With Chromosomal Anomalies of Twin Unknown status NCT02732717
12 Pomegranate to Reduce Maternal and Fetal Oxidative Stress and Improve Outcome in Pregnancies Complicated With Preterm Premature Rupture of the Membranes Unknown status NCT01584323
13 Efficacy and Efficiency of Uterocervical Angle for Prediction of Preterm Labor in Patients With Idiopathic Polyhydramnios: a Prospective Cohort Study Completed NCT03828695
14 Classification of Fetal Breathing Patterns in the Maturing Upper Airway: Spectral Waveform Analysis of Amniotic Fluid Flow Dynamics in Normal Development, Polyhydramnios, and Oligohydramnios Completed NCT00066976
15 Continuous Glucose Monitoring in Women With Type 1 Diabetes in Pregnancy Trial Completed NCT01788527
16 Maternal and Perinatal Outcome in Women With History of Premature Labor in Previous Pregnancy and Submitted to Active Search of Genital Infection Completed NCT01375439
17 Chewing Gums to Stimulate Intestinal Motility After Cesarean Section: A Randomized Controlled Trial Completed NCT02386748
18 Effect of Adjunctive Misoprostol on Blood Loss at Vaginal Delivery Completed NCT02411916
19 Effects of Co-administered Oxytocin and Intravenous Tranexamic Acid on Prevention of Postpartum Hemorrhage in Pregnant Women With Twin Pregnancy Undergoing Elective Cesarean Section: A Double-Blind Randomized Clinical Trial Recruiting NCT03778242 oxytocin;TA;placebo to TA
20 Effects of Co-administered Sublingual Misoprostol and Intravenous Tranexamic Acid on Prevention of Postpartum Hemorrhage in Pregnant Women With Twin Pregnancy Undergoing Elective Cesarean Section: A Double-Blind Randomized Clinical Trial Recruiting NCT03774524 Misoprostol;TA;placebo to misoprostol;placebo to TA
21 The Effect of Carbetocin Versus Oral Tranexamic Acid Plus, Buccal Misoprostol on Blood Loss After Vaginal Delivery: a Randomized Controlled Trial Recruiting NCT03708497 carbetocin;Tranexamic acid plus misoprostol;misoprostol
22 Feto-Fetal Transfusion Syndrome in Multiple Pregnancies Recruiting NCT04148859
23 A Comparison Between the Effect of Oxytocin Only and Oxytocin Plus Propranolol on Induction of Labor in Term Pregnancy Recruiting NCT03533699 Propranolol;Placebo Oral Tablet
24 Antenatal and Intrapartum Risk Factors Associated With Neonatal Hypoxic Ischemic Encephalopathy Not yet recruiting NCT04364932
25 Colloid Preload Versus Crystalloid Co-load in Cesarean Section Under Spinal Anesthesia Randomized Controlled Trial Terminated NCT03107598 colloid preload
26 Pilot Study-A Cost and Time Savings Comparison of Lamellar Body Count and FLM II Withdrawn NCT00613977

Search NIH Clinical Center for Polyhydramnios

Cochrane evidence based reviews: polyhydramnios

Genetic Tests for Polyhydramnios

Genetic tests related to Polyhydramnios:

# Genetic test Affiliating Genes
1 Polyhydramnios 29

Anatomical Context for Polyhydramnios

MalaCards organs/tissues related to Polyhydramnios:

40
Placenta, Lung, Testes, Heart, Brain, Kidney, Liver

Publications for Polyhydramnios

Articles related to Polyhydramnios:

(show top 50) (show all 2376)
# Title Authors PMID Year
1
Phenotype-genotype correlation in antenatal and neonatal variants of Bartter syndrome. 54 61
19096086 2009
2
Steady-state levels of aquaporin 1 mRNA expression are increased in idiopathic polyhydramnios. 61 54
16522429 2006
3
A novel model of polyhydramnios: amniotic fluid volume is increased in aquaporin 1 knockout mice. 61 54
15970890 2005
4
Prenatal findings in epidermolysis bullosa with pyloric atresia in a family not known to be at risk. 61 54
15912478 2005
5
The importance of investigating for uniparental disomy in prenatally identified balanced acrocentric rearrangements. 54 61
11857621 2002
6
Prenatal diagnosis of thanatophoric dysplasia by mutational analysis of the fibroblast growth factor receptor 3 gene and a proposed correction of previously published PCR results. 54 61
10073901 1999
7
Open neural tube defects: immunocytochemical demonstration of neuroepithelial cells in amniotic fluid. 54 61
9067106 1997
8
Pregnancy complications and adverse outcomes in placental chorioangioma: a retrospective cohort analysis. 61
30431372 2020
9
Comparison of criteria of International Association of Diabetes and Pregnancy Study Groups (IADPSG) with National Institute for Health and Care Excellence (NICE) for diagnosis of gestational diabetes mellitus. 61
32388777 2020
10
Delivery mode and perinatal outcomes after diagnosis of oligohydramnios at term in China. 61
30486718 2020
11
Polyhydramnios and abnormal foetal heart rate patterns in a foetus with Prader-Willi syndrome: A case report. 61
32528861 2020
12
A comparison of the risk of cesarean section in gestational diabetes mellitus patients supplemented antenatally with vitamin D containing supplements versus placebo: A systematic review and meta-analysis of double-blinded randomized controlled trials. 61
32517428 2020
13
Prevention of perinatal complications in pregnant women with chronic papillomavirus infection. 61
32564038 2020
14
Sacrococcygeal teratoma with preterm delivery: a case report. 61
32552844 2020
15
Ultrasound markers for prediction of complex gastroschisis and adverse outcome: longitudinal prospective nationwide cohort study. 61
31613023 2020
16
[Kagami-Ogata Syndrome: An Anomaly of the Ribs as a Pathognomonic Feature for the Clinical Diagnosis of an (epi)Genetic Syndrome]. 61
31853915 2020
17
Impact of Perinatal Primary Hyperparathyroidism on Maternal and Fetal and Neonatal Outcomes: Retrospective Case Series. 61
32238314 2020
18
Maternal Work and Spontaneous Preterm Birth: A Multicenter Observational Study in Brazil. 61
32546709 2020
19
A giant symptomatic placental chorioangioma managed with a histoacryl injection. 61
32372255 2020
20
Marginal placental cord insertion: the need for follow up? 61
32397941 2020
21
Fetal congenital midaortic syndrome with unilateral renal artery stenosis prenatally presenting with polyhydramnios and postpartum as hyponatremic hypertensive syndrome. 61
32444441 2020
22
Prenatal and perinatal risk and protective factors for psychosis: a systematic review and meta-analysis. 61
32220288 2020
23
False diagnosis of small for gestational age and macrosomia - clinical and sonographic predictors. 61
32429707 2020
24
Outcomes in the giant omphalocele population: A single center comprehensive experience. 61
32475506 2020
25
Pregnancy related pharmacokinetics and antimicrobial prophylaxis during fetal surgery, cefazolin and clindamycin as examples. 61
32441341 2020
26
Esophageal Atresia: Associated Anomalies, Mortality, and Morbidity in Jordan. 61
32432365 2020
27
GATAD2B-associated neurodevelopmental disorder (GAND): clinical and molecular insights into a NuRD-related disorder. 61
31949314 2020
28
Kagami-Ogata syndrome: an important differential diagnosis to Beckwith-Wiedemann syndrome. 61
31994200 2020
29
Delayed Diagnosis in Esophageal Atresia and Tracheoesophageal Fistula: Case Study. 61
32384331 2020
30
Mirror syndrome due to anti-Jra alloimmunization. 61
32416899 2020
31
Society for Maternal-Fetal Medicine (SMFM) Consult Series #52: Diagnosis and Management of Fetal Growth Restriction. 61
32407785 2020
32
Changes in treatment needs of hypoparathyroidism during pregnancy and lactation: A case series. 61
32350890 2020
33
Effectiveness of telemedicine for pregnant women with gestational diabetes mellitus: an updated meta-analysis of 32 randomized controlled trials with trial sequential analysis. 61
32252676 2020
34
Adverse perinatal outcomes in 665,244 term and post-term deliveries-a Norwegian population-based study. 61
32146227 2020
35
Ferulic acid confers protection on islet β cells and placental tissues of rats with gestational diabetes mellitus. 61
32359381 2020
36
A two-year follow-up of asfotase alfa replacement in a patient with hypophosphatasia: clinical, biochemical, and radiological evaluation. 61
32267350 2020
37
Perinatal outcome of pregnancies complicated by placental chorioangioma: systematic review and meta-analysis. 61
31034661 2020
38
[Chorangioma of the Placenta - A Rare Placental Cause of Fetal High Output Cardiac Failure]. 61
31559610 2020
39
Esophageal atresia and tracheoesophageal fistula: prenatal sonographic Manifestation from early to late pregnancy. 61
32304613 2020
40
Recognizing the unique prenatal phenotype of Prader-Willi Syndrome (PWS) indicates the need for a diagnostic methylation test. 61
32297338 2020
41
Novel features of PIK3CA-Related Overgrowth Spectrum: Lesson from an aborted fetus presenting a de novo constitutional PIK3CA mutation. 61
31568861 2020
42
The KLHL40 c.1516A>C is a Chinese-specific founder mutation causing nemaline myopathy 8: Report of six patients with pre- and postnatal phenotypes. 61
32352246 2020
43
[Etiological diagnosis and clinical evaluation of isolated fetal ascites]. 61
32375431 2020
44
Inherited salt-losing tubulopathy: An old condition but a new category of tubulopathy. 61
31830341 2020
45
Hydrops fetalis and neonatal abdominal compartment syndrome continuum from immature gastric teratoma: a case report. 61
32340629 2020
46
The effect of increased amnion volume severity on fetal Doppler indices and perinatal outcomes in idiopathic polyhydramnios. 61
30081701 2020
47
Superior Vena Cava Syndrome and Hypoxic Ischemic Encephalopathy Secondary to a Massive, Right-Sided Immature Cervical Teratoma. 61
31335287 2020
48
"INTERGROWTH21st vs customized fetal growth curves in the assessment of the neonatal nutritional status: a retrospective cohort study of gestational diabetes". 61
32131758 2020
49
The influence of different inositol stereoisomers supplementation in pregnancy on maternal gestational diabetes mellitus and fetal outcomes in high-risk patients: a randomized controlled trial. 61
30558466 2020
50
Development of a prenatal clinical care pathway for uncomplicated gastroschisis and literature review. 61
32145003 2020

Variations for Polyhydramnios

ClinVar genetic disease variations for Polyhydramnios:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 MTM1 NM_000252.2(MTM1):c.1262G>T (p.Arg421Leu)SNV Pathogenic 599006 rs587783772 X:149828138-149828138 X:150659665-150659665
2 46;XX;t(10;15)(q25.2;q11.2)Translocation Pathogenic 267923
3 KCNQ1 NM_181798.1(KCNQ1):c.704A>G (p.Lys235Arg)SNV Pathogenic/Likely pathogenic 52953 rs12720458 11:2606494-2606494 11:2585264-2585264
4 GLDN NM_181789.4(GLDN):c.1305G>A (p.Trp435Ter)SNV Pathogenic/Likely pathogenic 488521 rs775011495 15:51696600-51696600 15:51404403-51404403
5 ABCC8 NM_000352.6(ABCC8):c.1024G>T (p.Gly342Trp)SNV Likely pathogenic 523360 rs763028380 11:17474818-17474818 11:17453271-17453271
6 STRADA NM_001003787.4(STRADA):c.792T>A (p.Ser264Arg)SNV Uncertain significance 374250 rs1057519011 17:61784061-61784061 17:63706701-63706701

Expression for Polyhydramnios

Search GEO for disease gene expression data for Polyhydramnios.

Pathways for Polyhydramnios

Pathways related to Polyhydramnios according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.26 SLC12A1 KCNJ1 CLCNKB

GO Terms for Polyhydramnios

Cellular components related to Polyhydramnios according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.77 SLC12A1 RAPSN MUSK MTM1 KCNQ1 KCNJ1
2 membrane GO:0016020 9.55 STK11 SLC12A1 RAPSN MUSK MTM1 MAGED2

Biological processes related to Polyhydramnios according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.63 SLC12A1 KCNQ1 CLCNKB AQP9 AQP8 AQP3
2 potassium ion transport GO:0006813 9.58 SLC12A1 KCNQ1 KCNJ1
3 cellular response to cAMP GO:0071320 9.43 KCNQ1 AQP9 AQP8
4 urea transmembrane transport GO:0071918 9.37 AQP9 AQP3
5 glycerol transport GO:0015793 9.32 AQP9 AQP3
6 excretion GO:0007588 9.13 KCNJ1 CLCNKB AQP9
7 water transport GO:0006833 8.8 AQP9 AQP8 AQP3

Molecular functions related to Polyhydramnios according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.54 KCNQ1 KCNJ1 CLCNKB
2 protein kinase activator activity GO:0030295 9.32 STRADA STK11
3 urea transmembrane transporter activity GO:0015204 9.26 AQP9 AQP3
4 glycerol channel activity GO:0015254 9.16 AQP9 AQP3
5 channel activity GO:0015267 9.13 AQP9 AQP8 AQP3
6 water channel activity GO:0015250 8.8 AQP9 AQP8 AQP3

Sources for Polyhydramnios

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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