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FUSE
MCID: PLY150
MIFTS: 31

Polykaryocytosis Inducer (FUSE)

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Aliases & Classifications for Polykaryocytosis Inducer

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MalaCards integrated aliases for Polykaryocytosis Inducer:

Name: Polykaryocytosis Inducer 56
Fuse 56

External Ids:

OMIM 56 174750
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Summaries for Polykaryocytosis Inducer

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MalaCards based summary : Polykaryocytosis Inducer, also known as fuse, is related to incisors, fused mandibular and teeth, fused. An important gene associated with Polykaryocytosis Inducer is FUSE (Polykaryocytosis Promoter). The drugs Midazolam and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and skeletal muscle.

More information from OMIM: 174750
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Related Diseases for Polykaryocytosis Inducer

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Diseases related to Polykaryocytosis Inducer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 830)
# Related Disease Score Top Affiliating Genes
1 incisors, fused mandibular 12.5
2 teeth, fused 12.5
3 sirenomelia 11.9
4 solitary median maxillary central incisor 11.9
5 ackerman syndrome 11.9
6 klippel-feil syndrome 1, autosomal dominant 11.7
7 pyramidal molars-abnormal upper lip syndrome 11.7
8 klippel-feil syndrome 11.6
9 chromosome 2q35 duplication syndrome 11.6
10 fraser syndrome 1 11.5
11 craniosynostosis 11.5
12 spondyloarthropathy 1 11.5
13 fraser-like syndrome 11.5
14 rela fusion-positive ependymoma 11.5
15 apert syndrome 11.5
16 syndactyly, type v 11.5
17 horseshoe kidney 11.4
18 schizencephaly 11.4
19 synpolydactyly 11.3
20 acute promyelocytic leukemia 11.3
21 anaplastic large cell lymphoma 11.3
22 synostosis 11.3
23 myxoid liposarcoma 11.3
24 aortic valve disease 1 11.3
25 greig cephalopolysyndactyly syndrome 11.3
26 acrocallosal syndrome 11.3
27 thrombocytopenia-absent radius syndrome 11.3
28 sacral defect with anterior meningocele 11.3
29 becker nevus syndrome 11.3
30 caffey disease 11.2
31 spondylocostal dysostosis 5 11.2
32 syndactyly, type iii 11.2
33 spondylocostal dysostosis 3, autosomal recessive 11.2
34 isolated klippel-feil syndrome 11.2
35 brachydactyly, type a1 11.2
36 tarsal-carpal coalition syndrome 11.2
37 baller-gerold syndrome 11.2
38 ankyloblepharon-ectodermal defects-cleft lip/palate 11.1
39 craniosynostosis 1 11.1
40 acromesomelic dysplasia, hunter-thompson type 11.1
41 microphthalmia with limb anomalies 11.1
42 craniofacial dysmorphism, skeletal anomalies, and mental retardation syndrome 11.1
43 focal dermal hypoplasia 11.1
44 robinow syndrome 11.1
45 bladder exstrophy-epispadias-cloacal exstrophy complex 11.1
46 ring chromosome 15 11.1
47 ring chromosome 20 11.1
48 saethre-chotzen syndrome 10.9
49 ankyloglossia with or without tooth anomalies 10.9
50 atelosteogenesis, type iii 10.9

Graphical network of the top 20 diseases related to Polykaryocytosis Inducer:



Diseases related to Polykaryocytosis Inducer
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Symptoms & Phenotypes for Polykaryocytosis Inducer

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Clinical features from OMIM:

174750
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Drugs & Therapeutics for Polykaryocytosis Inducer

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Drugs for Polykaryocytosis Inducer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
3 Cola Phase 4
4 Neurotransmitter Agents Phase 4
5 Narcotics Phase 4
6 Hypnotics and Sedatives Phase 4
7 Anti-Anxiety Agents Phase 4
8 Psychotropic Drugs Phase 4
9 Analgesics, Opioid Phase 4
10 Analgesics Phase 4
11 Anesthetics, General Phase 4
12 GABA Modulators Phase 4
13 Anesthetics, Intravenous Phase 4
14 Calcium, Dietary Phase 4
15
Calcium Nutraceutical Phase 4 7440-70-2 271
16
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
17
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
18 Hormone Antagonists Phase 3
19 Estrogen Receptor Antagonists Phase 3
20 Antineoplastic Agents, Hormonal Phase 3
21 Estrogen Antagonists Phase 3
22 Aromatase Inhibitors Phase 3
23 Hormones Phase 3
24 Estrogens Phase 3
25
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
26 English walnut Approved Phase 2
27
Tacrolimus Approved, Investigational Phase 1, Phase 2 104987-11-3 445643 439492 6473866
28 Vaccines Phase 2
29 abobotulinumtoxinA Phase 2
30 Cholinergic Agents Phase 2
31 incobotulinumtoxinA Phase 2
32 Botulinum Toxins Phase 2
33 Botulinum Toxins, Type A Phase 2
34 Antioxidants Phase 2
35 Pharmaceutical Solutions Phase 1, Phase 2
36 Imatinib Mesylate Phase 2 220127-57-1 123596
37 Immunoglobulins Phase 1
38 Antibodies Phase 1
39 Antibodies, Monoclonal Phase 1
40
Iodine Approved, Investigational 7553-56-2 807
41
Povidone Approved 9003-39-8
42
Povidone-iodine Approved 25655-41-8
43
Blueberry Approved
44
Metronidazole Approved 443-48-1 4173
45
Hydroxychloroquine Approved 118-42-3 3652
46
tannic acid Approved 1401-55-4
47
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
48
Sulfasalazine Approved 599-79-1 5353980 5359476
49
Adenosine Approved, Investigational 58-61-7 60961
50
Nitroglycerin Approved, Investigational 55-63-0 4510

Interventional clinical trials:

(show top 50) (show all 82)
# Name Status NCT ID Phase Drugs
1 Clinical Trial to Evaluate the Efficacy and Safety of SurgiFill™ on Spinal Fusion -Comparison Between Autograft Mixed With SurgiFill™ and Autograft in Spinal Fusion- Unknown status NCT02466048 Phase 4
2 Single Center, Prospective, Open Label Post Marketing Study of EndoChoice's Fuse® Endoscopic System Performance In Routine Practice Completed NCT02439502 Phase 4
3 Fentanyl Use for Sedation in Esophagogastroduodenoscopy (FUSE): a Phase 4, Randomized, Double-blind, Placebo-controlled Trial of Fentanyl Added to Midazolam Compared to Midazolam Alone for Sedation in Routine Upper Endoscopy Completed NCT01514695 Phase 4 Midazolam;Fentanyl
4 Actifuse ABX and Local Bone Have Comparable Outcomes to Local Bone in Instrumented Multi-Level Adult Spinal Deformity Patients Terminated NCT01852747 Phase 4
5 A Randomized Controlled Trial Of The Use Of Aromatase Inhibitors, Alone And In Combination With Growth Hormone In Adolescent Boys With Idiopathic Short Stature Completed NCT01248416 Phase 3 Aromatase Inhibitor;Growth Hormone;Aromatase Inhibitor and Growth Hormone
6 A Prospective, Multi-Center Clinical Study to Assess the Saftey and Effectiveness of the Impliant TOPS System Completed NCT00405691 Phase 3
7 Adjustment of Optimal Immune System by Using Cytokine Cocktails Before Applying DC Vaccine Unknown status NCT00521287 Phase 2
8 Transurethral Autologous Myoblast Injection for Treatment of Urinary Incontinence in Children With Bladder Exstrophy Unknown status NCT02075216 Phase 1, Phase 2
9 Comparative Study of the Efficacy and Safety of Liposome Encapsulated Botulinum Toxin-A (Lipotoxin) Versus Normal Saline Instillation in Treatment of Patients With Refractory Overactive Bladder Syndrome Completed NCT01167257 Phase 2 Liposome encapsulated botulinum toxin A;Normal saline instillation
10 Benefits of Walnuts for Male Reproductive Health Completed NCT01505140 Phase 2
11 Transplantation of Myoblasts to Duchenne Muscular Dystrophy (DMD) Patients Recruiting NCT02196467 Phase 1, Phase 2
12 A RANDOMIZED NON-COMPARATIVE PHASE 2 PILOT STUDY TESTING THE VALUE OF IMATINIB MESYLATE AS AN EARLY TREATMENT OF COVID-19 DISEASE IN AGED HOSPITALIZED PATIENTS. Not yet recruiting NCT04357613 Phase 2 Experimental drug
13 EVALUATION Of A NEW THERAPEUTIC STRATEGY FOR URETHRAL SPHINCTER INSUFFICIENCY BASED ON THE INTRA-URETHRAL IMPLANTATION OF AUTOLOGOUS MYOFIBERS WITH THEIR SATELLITE CELLS Completed NCT00472069 Phase 1
14 An Ascending Single- and Multiple-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneous Gimsilumab in Healthy Subjects and Subjects With Ankylosing Spondylitis Completed NCT04205851 Phase 1 KIN-1901;Placebo
15 An Open Label, Phase Ib Study to Evaluate the Impact of Low Doses of Nilotinib Treatment on Safety, Tolerability and Biomarkers in Huntington's Disease Recruiting NCT03764215 Phase 1 Nilotinib 150 MG
16 Effect of a Longer Withdrawal Time or of the Use of a Wide-angle Endoscope on the Adenoma Detection Rate of Screening Colonoscopy Unknown status NCT02985944
17 A Comparative Study of the Safety and Efficacy of Face Talc Slurry and Iodopovidone for Pleurodesis Unknown status NCT00430664
18 A Study to Evaluate the Safety and Effectiveness of the TOPS™ SP System Unknown status NCT03247166
19 A Study to Evaluate the Safety and Effectiveness of the TOPS System Unknown status NCT02234154
20 A Study to Evaluate the Safety and Effectiveness of the TOPS System Unknown status NCT01933607
21 Assessment of Cyclofusion Capabilities of Normal Subjects and Patients With 3D Dynamic Random-dot Stereograms Unknown status NCT03322111
22 Use of Bedside Ultrasound in Emergency Department Patients With Concern for Pulmonary Embolism to Reduce CT Imaging Unknown status NCT03532165
23 Ultrasound-CT Fusion System for Interventional Radiology Procedures Unknown status NCT03226535
24 Neutrophils Function and Identification of Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis). Unknown status NCT01862068
25 Full Spectrum vs. Standard Forward-viewing Colonoscopy With and Without Right-colon Retroflexion: a Randomized, Bicentric Back-to-back Study Completed NCT02117674
26 A 4-arm Randomized Controlled Trial of Fuse®, EndoCuff™, EndoRings™ and Standard Colonoscopy Completed NCT02345889
27 Exploratory Study of Upper and Lower Endoscopic Fuse System Completed NCT02651857
28 Evaluation of Oesogastroduodenoscopy With Vision to 245 ° (Full Spectrum Endoscopy) to View the Main Disc and Accessory Completed NCT02859883
29 Identifying Prostate Brachytherapy Seeds Using MRI Completed NCT01878058
30 Single-Center, Exploratory Study of EndoChoice's Upper&Lower Endoscopic Systems Utilizing EndoChoice's Full Spectrum Optical Technology Completed NCT02143284
31 Evaluation of the Colonoscope With Vision to 330 ° (Full Spectrum Endoscopy) in the Detection of Colorectal Adenomas Completed NCT02859870
32 Post-bariatric Abdominoplasty: Skin Sensation Evaluation. Completed NCT00831610
33 Accuracy of Commercially Available Heart Rate Monitors II Completed NCT02818244
34 Human Sperm Binding to Transgenic Mouse Eggs Completed NCT00340587
35 Validation of a New Method of Measuring Spinal Flexibility in Axial Spondyloarthritis Using Inertial Motion (IMU) Sensors Completed NCT03159767
36 In Vivo Evaluation of Image Registration Techniques During Endovascular Repair Completed NCT03116880
37 Family Studies of the Genetics of Ankylosing Spondylitis Completed NCT00081562
38 Subjective Image Quality in Stereoscopic Image Modifications Completed NCT01624415
39 Sacroiliac Joint Fusion With iFuse Implant System (SIFI) Completed NCT01640353
40 Mindfulness and Acceptance-Based Treatments for Social Anxiety: Defusion App Completed NCT02265211
41 Molecular Image-directed, 3D Ultrasound-guided Biopsy of the Prostate Completed NCT02013414
42 Effect of a Blueberry Enriched Diet on Skeletal Muscle Progenitor Cells Completed NCT04262258
43 Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study Completed NCT00056719
44 Randomized Multi-Center Post Market Clinical Study to Evaluate the Safety and Performance of NextraTM for Use in Foot Surgery to Fuse the Proximal-interphalangeal- Joints Completed NCT01604070
45 The CAROLE (CArdiac Related Oncologic Late Effects) Study Completed NCT03235427
46 Lumbar Fusion or Non-operative Care for Treatment of Presumed Discogenic Pain: A Randomized Study Completed NCT02695576
47 Uni-center, Retrospective Observational Study to Compare Outcomes of Fistulectomy With Primary Sphincteroplasty, Advancement Flap and Full-thickness Low Rectum Posterior Mobilization After Excision of a High Recurrent Anorectal Fistula Completed NCT04357210
48 Accuracy of Commercially Available Heart Rate Monitors: A Prospective Study Completed NCT02697214
49 NaF PET/MRI Evaluation for Bone Metastases in Breast Cancer Completed NCT02103634
50 Risk Factors for Proximal Junctional Kyphosis Assessment After Spinal Instrumentation Completed NCT02881580

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Genetic Tests for Polykaryocytosis Inducer

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Anatomical Context for Polykaryocytosis Inducer

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MalaCards organs/tissues related to Polykaryocytosis Inducer:

40
Bone, Brain, Skeletal Muscle, Heart, Prostate, Liver, T Cells
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Publications for Polykaryocytosis Inducer

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Articles related to Polykaryocytosis Inducer:

(show top 50) (show all 9523)
# Title Authors PMID Year
1
Gene assignment of a polykaryocytosis promoter (FUSE) to chromosome 10 in man. 61 56
752487 1978
2
Evaluating the effect of silver nanoparticles on bacteriophage lytic infection cycle-a mechanistic understanding. 61
32504909 2020
3
Sequential vessel segmentation via deep channel attention network. 61
32447262 2020
4
Sperm ultrastructure and spermatogenesis in the Japanese beetle Popillia japonica (Coleoptera, Scarabaeidae). 61
32416441 2020
5
Visual Object Tracking by Hierarchical Attention Siamese Network. 61
31536029 2020
6
Characterization of Skeletal Muscle Endocrine Control in an In Vitro Model of Myogenesis. 61
32107602 2020
7
Efficient Robust Model Fitting for Multistructure Data Using Global Greedy Search. 61
30843859 2020
8
Temporal frequency joint sparse optimization and fuzzy fusion for motor imagery-based brain-computer interfaces. 61
32311375 2020
9
Tea extract increases cell fusion via regulation of cell surface DC-STAMP. 61
32420461 2020
10
Posterior Fusion for the Subaxial Cervical Spine: A Review of the Major Techniques. 61
32508546 2020
11
NAADP-regulated two-pore channels drive phagocytosis through endo-lysosomal Ca2+ nanodomains, calcineurin and dynamin. 61
32510172 2020
12
Dimensionality Reduction of Hyperspectral Imagery Based on Spatial-Spectral Manifold Learning. 61
30946691 2020
13
Decomposing the composite face effect: Evidence for non-holistic processing based on the ex-Gaussian distribution. 61
31952449 2020
14
Recurrent traumatic atlantoaxial rotatory subluxation: Case report. 61
32382411 2020
15
Veterinary Intern Program for Entrustable Professional Activities Skills, a.k.a. Intern Boot Camp. 61
31194630 2020
16
ASS1 Overexpression: A Hallmark of Sonic Hedgehog Hepatocellular Adenomas; Recommendations for Clinical Practice. 61
32490318 2020
17
Radiogenomics model for overall survival prediction of glioblastoma. 61
32488372 2020
18
Cardiac VFM visualization and analysis based on YOLO deep learning model and modified 2D continuity equation. 61
32417649 2020
19
Sertoli cells in the freshwater pearl mussel Margaritifera laevis (Bivalvia: Margaritiferidae): A histological and ultrastructural study. 61
32473707 2020
20
Harmonized representation learning on dynamic EHR graphs. 61
32339747 2020
21
Reliable Vision-Based Grasping Target Recognition for Upper Limb Prostheses. 61
32520717 2020
22
Liquid-liquid phase separation of type II diabetes-associated IAPP initiates hydrogelation and aggregation. 61
32414928 2020
23
Spatiotemporal Interaction Residual Networks with Pseudo3D for Video Action Recognition. 61
32492842 2020
24
[A Case of Unruptured Cerebral Aneurysm Arising from Duplicate Origin of the Middle Cerebral Artery]. 61
32572003 2020
25
Bio-inspired micro glue threads fabricated by liquid bridge-to-solidification as an effective sensing platform. 61
32573204 2020
26
Where does the cargo go?: Solutions to provide experimental support for the "extracellular vesicle cargo transfer hypothesis". 61
32060725 2020
27
Osteoclast formation at the bone marrow/bone surface interface: Importance of structural elements, matrix, and intercellular communication. 61
32563679 2020
28
Natural human chimeras: A review. 61
32565253 2020
29
3D dense connectivity network with atrous convolutional feature pyramid for brain tumor segmentation in magnetic resonance imaging of human heads. 61
32568669 2020
30
A viable method to enhance the electrical conductivity of CNT bundles: direct in situ TEM evaluation. 61
32543632 2020
31
An improved functional analysis of linker-mediated complex (iFALC) strategy. 61
32327258 2020
32
Endomembrane architecture and dynamics during secretion of the extracellular matrix of the unicellular charophyte, Penium margaritaceum. 61
31974570 2020
33
Activated α2-macroglobulin binding to cell surface GRP78 induces trophoblastic cell fusion. 61
32541810 2020
34
Extracellular Matrix in Secondary Palate Development. 61
31513730 2020
35
Need to Amplify Health Security? Fuse Academia and Practice. 61
32492355 2020
36
Fuse to defuse: a self-limiting ribonuclease-ring nuclease fusion for type III CRISPR defence. 61
32347937 2020
37
Endogenous glutamatergic inputs to the Parabrachial Nucleus/Kölliker-Fuse Complex determine respiratory rate. 61
32036030 2020
38
HLPpred-Fuse: improved and robust prediction of hemolytic peptide and its activity by fusing multiple feature representation. 61
32145017 2020
39
Liposomal delivery of functional transmembrane ion channels into the cell membranes of target cells; a potential approach for the treatment of channelopathies. 61
31756462 2020
40
Deep learning on mammary glands distribution for architectural distortion detection in digital breast tomosynthesis. 61
32485700 2020
41
Anatomical Attention Guided Deep Networks for ROI Segmentation of Brain MR Images. 61
31899417 2020
42
Taxonomic revision of the genus Zygorhizidium: Zygorhizidiales and Zygophlyctidales ord. nov. (Chytridiomycetes, Chytridiomycota). 61
32467913 2020
43
Exploring Structural Knowledge for Automated Visual Inspection of Moving Trains. 61
32559172 2020
44
Rab11 is essential for lgl mediated JNK-Dpp signaling in dorsal closure and epithelial morphogenesis in Drosophila. 61
32562757 2020
45
Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta. 61
32482863 2020
46
Acute inhibition of centriolar satellite function and positioning reveals their functions at the primary cilium. 61
32555591 2020
47
Detection of TMPRSS2-ERG Fusion Transcript in Biopsy Specimen of Prostate Cancer Patients: A Single Centre Experience. 61
32573479 2020
48
VAMP4 maintains a Ca2+-sensitive pool of spontaneously recycling synaptic vesicles. 61
32532887 2020
49
Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles. 61
32514112 2020
50
A novel class of selective CK2 inhibitors targeting its open hinge conformation. 61
32283296 2020
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Variations for Polykaryocytosis Inducer

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Expression for Polykaryocytosis Inducer

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Search GEO for disease gene expression data for Polykaryocytosis Inducer.
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Pathways for Polykaryocytosis Inducer

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GO Terms for Polykaryocytosis Inducer

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Sources for Polykaryocytosis Inducer

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
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70 Tocris
71 UMLS
72 UMLS via Orphanet
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