PR
MCID: PLY039
MIFTS: 21

Polymorphic Reticulosis (PR)

Categories: Rare diseases

Aliases & Classifications for Polymorphic Reticulosis

MalaCards integrated aliases for Polymorphic Reticulosis:

Name: Polymorphic Reticulosis 52 71
Malignant Histiocytosis 71
Nk-Cell Malignancy 52
Pr 52

Classifications:



External Ids:

UMLS 71 C0019623 C2350168

Summaries for Polymorphic Reticulosis

MalaCards based summary : Polymorphic Reticulosis, also known as malignant histiocytosis, is related to pr interval, variation in and atrial tachyarrhythmia with short pr interval. Affiliated tissues include nk cells, t cells and b cells.

Related Diseases for Polymorphic Reticulosis

Diseases related to Polymorphic Reticulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 407)
# Related Disease Score Top Affiliating Genes
1 pr interval, variation in 12.6
2 atrial tachyarrhythmia with short pr interval 12.4
3 phosphoribosylpyrophosphate synthetase superactivity 12.3
4 pityriasis rosea 11.9
5 first-degree atrioventricular block 11.6
6 second-degree atrioventricular block 11.6
7 palindromic rheumatism 11.6
8 rheumatic fever 11.5
9 prieto x-linked mental retardation syndrome 11.4
10 pierre robin syndrome and oligodactyly 11.3
11 pierre robin syndrome 11.3
12 epidermolysis bullosa dystrophica, pretibial 11.2
13 epidermolysis bullosa pruriginosa 11.2
14 hemifacial atrophy, progressive 11.2
15 peeling skin syndrome 11.2
16 facial hemiatrophy 11.2
17 chaotic atrial tachycardia 11.2
18 breast cancer 10.6
19 atrioventricular block 10.5
20 endometrial cancer 10.5
21 progressive familial heart block, type ia 10.4
22 lethal midline granuloma 10.4
23 lymphoma 10.4
24 human immunodeficiency virus type 1 10.3
25 atrial fibrillation 10.3
26 alzheimer disease 10.3
27 pancreatic ductal adenocarcinoma 10.3
28 hepatosplenic t-cell lymphoma 10.3
29 left bundle branch hemiblock 10.3
30 pericarditis 10.3
31 lymphomatoid granulomatosis 10.3
32 adenocarcinoma 10.3
33 dengue virus 10.2
34 in situ carcinoma 10.2
35 syncope 10.2
36 peripheral t-cell lymphoma 10.2
37 cardiac conduction defect 10.2
38 hepatitis c virus 10.2
39 ductal carcinoma in situ 10.2
40 amyotrophic lateral sclerosis 1 10.2
41 progressive familial heart block, type ib 10.2
42 right bundle branch block 10.2
43 constipation 10.2
44 lateral sclerosis 10.2
45 coronary heart disease 1 10.2
46 cold agglutinin disease 10.2
47 heart block, congenital 10.1
48 pulmonary hypertension, primary, 3 10.1
49 endometriosis 10.1
50 breast ductal carcinoma 10.1

Graphical network of the top 20 diseases related to Polymorphic Reticulosis:



Diseases related to Polymorphic Reticulosis

Symptoms & Phenotypes for Polymorphic Reticulosis

Drugs & Therapeutics for Polymorphic Reticulosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Study to Assess the Safety and Efficacy of Cobimetinib in Refractory Langerhans Cell Histiocytosis, LCH-Associated Neurodegenerative Disease, and Other Histiocytic Disorders. Not yet recruiting NCT04079179 Phase 2 Cobimetinib
2 CASPALLO: A Phase I Study Evaluating the Use of Allodepleted T Cells Transduced With Inducible Caspase 9 Suicide Gene After Haploidentical Stem Cell Transplantation Active, not recruiting NCT00710892 Phase 1

Search NIH Clinical Center for Polymorphic Reticulosis

Genetic Tests for Polymorphic Reticulosis

Anatomical Context for Polymorphic Reticulosis

MalaCards organs/tissues related to Polymorphic Reticulosis:

40
Nk Cells, T Cells, B Cells, Colon, Skin, Tonsil, Neutrophil

Publications for Polymorphic Reticulosis

Articles related to Polymorphic Reticulosis:

(show top 50) (show all 90)
# Title Authors PMID Year
1
Diagnosis and management of natural killer-cell malignancies. 61
21083476 2010
2
Nasal natural killer (NK)/T-cell lymphoma: clinical, histological, virological, and genetic features. 61
19593607 2009
3
Aggressive NK cell leukaemia after splenectomy: association with CD95-resistant memory T-cell proliferation and recalcitrant clinical course of haemophagocytic syndrome. 61
18510705 2008
4
[Future perspectives of research and clinical studies for NK-cell malignancy in Asia]. 61
18800602 2008
5
Polymorphic reticulosis: A case report. 61
23120326 2006
6
Natural killer-cell malignancies: diagnosis and treatment. 61
16179910 2005
7
Body cavity-based presentation of natural killer cell lymphoma. 61
15621817 2005
8
Blastic CD4 NK cell leukemia/lymphoma: a distinct clinical entity. 61
12127554 2002
9
[Midfacial necrosis secondary to cocaine-abuse]. 61
11998527 2002
10
Blastic natural killer cell lymphoma arising from the mediastinum with terminal deoxynucleotidyl transferase expression. 61
11148466 2001
11
Low frequency of HLA-A*0201 allele in patients with Epstein-Barr virus-positive nasal lymphomas with polymorphic reticulosis morphology. 61
10861473 2000
12
Specific c-kit mutations in sinonasal natural killer/T-cell lymphoma in China and Japan. 61
10811105 2000
13
[Epstein-Barr virus and malignant lymphoma]. 61
10741124 2000
14
Immunophenotypic and genotypic characterization of nasal lymphoma with polymorphic reticulosis morphology. 61
10362131 1999
15
Chronological changes in incidences of polymorphic reticulosis in Korea and Japan. 61
10202275 1999
16
Acute leukemia with the phenotype of a natural killer/T cell bipotential precursor. 61
10037270 1999
17
[Polymorphic reticulosis of the rhinopharynx]. 61
10520275 1999
18
[Centrofacial lymphoma, cause of middle line granuloma syndrome. Report of a case]. 61
9927781 1998
19
Malignant lymphomas of sinonasal region, including cases of polymorphic reticulosis: a retrospective clinicopathologic analysis of 34 cases. 61
9509678 1997
20
Epstein-Barr virus in lymphoproliferative diseases in the sino-nasal region: close association with CD56+ immunophenotype and polymorphic-reticulosis morphology. 61
8985084 1997
21
Idiopathic midline granuloma--current classification and management controversies. 61
8937608 1996
22
Angiocentric T-cell lymphoma of the tonsil: a case report. 61
8935531 1996
23
The spectrum of pulmonary vasculitis. 61
8901319 1996
24
[Two cases of lethal midline granuloma thought to be of natural killer cell origin]. 61
8822254 1996
25
[On classification of changes in necrotizing lesions of the midface]. 61
9045157 1996
26
Sinonasal T-cell lymphoma in the differential diagnosis of lethal midline granuloma using in situ hybridization for Epstein-Barr virus RNA. 61
8821949 1996
27
Coxiella burnetii in polymorphic lymphocytes in tissue and blood of patients with polymorphic reticulosis. 61
8722296 1995
28
Expression of interleukin-6 in polymorphic reticulosis--immunohistochemical study of 5 cases. 61
8750057 1995
29
Polymorphic reticulosis is a neoplasm of large granular lymphocytes with CD3+ phenotype. 61
8625143 1995
30
Polymorphic reticulosis is a neoplasm of large granular lymphocytes with CD3+ phenotype. 61
7828140 1995
31
Sinonasal lymphomas. 61
7979008 1994
32
Polymorphic reticulosis: a reappraisal. 61
8026825 1994
33
EBV in situ hybridization study for non-Hodgkin's lymphomas. 61
7993589 1994
34
Epstein-Barr virus in nasal T-cell lymphomas (polymorphic reticulosis/midline malignant reticulosis) in western China. 61
7522272 1994
35
Epstein-Barr virus in patients with polymorphic reticulosis (lethal midline granuloma) from China and Japan. 61
8200002 1994
36
Lethal midline granuloma in Okinawa with special emphasis on polymorphic reticulosis. 61
8200852 1994
37
Nasal T-cell lymphoma. 61
8172815 1994
38
[An ELISA for the detection of anti-neutrophil cytoplasmic antibodies using the cytoplasmic alpha-fraction--clinical use for the diagnosis of Wegener granulomatosis and for monitoring its activity]. 61
8176533 1994
39
[Cases of lethal midline granuloma (polymorphic reticulosis) at our department in a recent 10-year period]. 61
8345394 1993
40
Radiotherapy compared to chemotherapy as initial treatment of angiocentric centrofacial lymphoma (polymorphic reticulosis). 61
8466767 1993
41
Lethal midline granuloma: a case of Ki-1 lymphoma. 61
8191049 1993
42
Malignant lymphomas of the nasal cavity and Waldeyer's ring--clinicopathologic and immunohistochemical study. 61
1299234 1992
43
[Genotypic analysis of lethal midline granuloma]. 61
1491277 1992
44
[Polymorphic reticulosis: a type of lymphoma? Report of 3 cases]. 61
1340950 1992
45
Fireside conference 19. Wegener's granulomatosis and lethal midline granuloma. 61
1389398 1992
46
Non-Hodgkin's lymphoma confined to the nasal cavity: its relationship to the polymorphic reticulosis and results of radiation therapy. 61
2004957 1991
47
Angiocentric immunoproliferative lesion/T-cell non-Hodgkin's lymphoma and the acquired immune deficiency syndrome: a case report and review of the literature. 61
2245397 1990
48
Nasal lymphoma. A retrospective analysis of 60 cases. 61
2224776 1990
49
Polymorphic reticulosis and conventional lymphomas of the nose and upper aerodigestive tract: a clinicopathologic study of 70 cases, and immunophenotypic studies of 16 cases. 61
2210727 1990
50
Histopathological and immunohistochemical studies of polymorphic reticulosis. 61
2281681 1990

Variations for Polymorphic Reticulosis

Expression for Polymorphic Reticulosis

Search GEO for disease gene expression data for Polymorphic Reticulosis.

Pathways for Polymorphic Reticulosis

GO Terms for Polymorphic Reticulosis

Sources for Polymorphic Reticulosis

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70 Tocris
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72 UMLS via Orphanet
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