MCID: PLY040
MIFTS: 40

Polymorphous Low-Grade Adenocarcinoma

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Polymorphous Low-Grade Adenocarcinoma

MalaCards integrated aliases for Polymorphous Low-Grade Adenocarcinoma:

Name: Polymorphous Low-Grade Adenocarcinoma 53
Polymorphous Low Grade Adenocarcinoma 73

Classifications:



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UMLS 73 C1266086

Summaries for Polymorphous Low-Grade Adenocarcinoma

MalaCards based summary : Polymorphous Low-Grade Adenocarcinoma, also known as polymorphous low grade adenocarcinoma, is related to adenocarcinoma and pleomorphic adenoma. An important gene associated with Polymorphous Low-Grade Adenocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are MicroRNAs in cancer and DNA Damage. The drugs Gemcitabine and Antiviral Agents have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, tongue and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Polymorphous low-grade adenocarcinoma, often abbreviated PLGA, is a rare, asymptomatic, slow-growing... more...

Related Diseases for Polymorphous Low-Grade Adenocarcinoma

Diseases related to Polymorphous Low-Grade Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 31.4 CCND1 CTNNB1 KIT MUC1 NTRK3
2 pleomorphic adenoma 30.1 ACTC1 MUC1 S100B SERPINB5 TP63 VIM
3 squamous cell carcinoma 29.7 CCND1 CTNNB1 MKI67 MUC1 TP63
4 myoepithelioma 29.5 ACTC1 S100A1 S100B SERPINB5 TP63 VIM
5 adenoid cystic carcinoma 28.4 ACTC1 CCND1 CTNNB1 KIT MKI67 MUC1
6 adenoma 10.4
7 lymphangiectasis 10.3 ACTC1 VIM
8 ovarian fibrothecoma 10.3 ACTC1 KIT
9 glomangiomyoma 10.3 ACTC1 VIM
10 angiolipoma 10.3 ACTC1 VIM
11 intravascular papillary endothelial hyperplasia 10.3 ACTC1 VIM
12 cutaneous leiomyosarcoma 10.3 ACTC1 VIM
13 malignant peritoneal mesothelioma 10.3 MUC1 VIM
14 secretory meningioma 10.3 MUC1 VIM
15 mast-cell sarcoma 10.3 KIT VIM
16 spindle cell lipoma 10.3 ACTC1 VIM
17 nodular hidradenoma 10.2 MUC1 VIM
18 epithelioid leiomyosarcoma 10.2 ACTC1 VIM
19 clear cell ependymoma 10.2 MUC1 VIM
20 fasciitis 10.2 ACTC1 MUC1 VIM
21 benign metastasizing leiomyoma 10.2 ACTC1 VIM
22 parachordoma 10.2 ACTC1 MUC1 VIM
23 adenofibroma 10.2 ACTC1 MUC1 VIM
24 cribriform carcinoma 10.2 KIT TP63
25 bile duct adenoma 10.2 MUC1 VIM
26 polycystic liver disease 1 with or without kidney cysts 10.2 ACTC1 CEACAM3 MUC1
27 biphasic synovial sarcoma 10.2 MUC1 VIM
28 rhabdoid tumor predisposition syndrome 1 10.2 ACTC1 MUC1 VIM
29 granulosa cell tumor of the ovary 10.2 ACTC1 CEACAM3 VIM
30 papillary tumor of the pineal region 10.2 MUC1 S100A1 VIM
31 smooth muscle tumor 10.2 ACTC1 KIT VIM
32 angiosarcoma 10.2 KIT MUC1 VIM
33 giant cell tumor 10.2 ACTC1 MUC1 VIM
34 oncocytoma 10.2 KIT MUC1 VIM
35 clear cell meningioma 10.2 MUC1 VIM
36 adenosquamous carcinoma 10.2 KIT MUC1 TP63
37 localized hypertrophic neuropathy 10.2 MUC1 S100B
38 sclerosing perineurioma 10.2 MUC1 S100B
39 pericardial mesothelioma 10.2 MUC1 S100A1 VIM
40 pseudosarcomatous fibromatosis 10.2 ACTC1 CTNNB1 VIM
41 intracranial cysts 10.2 MUC1 S100B
42 desmoid tumor 10.2 CTNNB1 KIT
43 mesothelioma, malignant 10.2 CEACAM3 MUC1 VIM
44 hydromyelia 10.2 S100B VIM
45 malignant giant cell tumor of soft parts 10.2 ACTC1 S100B
46 malignant giant cell tumor 10.2 ACTC1 S100B
47 adenomyoma 10.2 CTNNB1 MUC1
48 non-functioning pituitary adenoma 10.2 MUC1 S100B
49 bednar tumor 10.2 S100B VIM
50 epithelioid malignant peripheral nerve sheath tumor 10.2 MUC1 S100B

Graphical network of the top 20 diseases related to Polymorphous Low-Grade Adenocarcinoma:



Diseases related to Polymorphous Low-Grade Adenocarcinoma

Symptoms & Phenotypes for Polymorphous Low-Grade Adenocarcinoma

GenomeRNAi Phenotypes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

26 (show all 40)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.98 MYB
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.98 NFIB VIM
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.98 CTNNB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.98 CTNNB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.98 NFIB
6 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.98 MYB
7 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.98 MYB
8 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.98 MYB
9 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.98 CCND1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.98 VIM
11 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.98 MYB
12 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.98 CCND1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.98 CCND1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.98 MYB
15 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.98 CCND1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.98 MYB
17 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.98 MYB
18 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.98 VIM
19 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.98 CCND1 CTNNB1 MYB NFIB VIM
20 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.98 VIM
21 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.98 VIM
22 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.98 CTNNB1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.98 CCND1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.98 CCND1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.98 CCND1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.98 CCND1 NFIB
27 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.98 VIM
28 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.98 VIM
29 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.98 NFIB
30 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.98 CCND1
31 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.98 CTNNB1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.98 CTNNB1
33 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.98 VIM
34 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.98 CTNNB1
35 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.98 CTNNB1 MYB
36 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.98 CTNNB1
37 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.98 CTNNB1
38 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.98 MYB
39 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.98 VIM
40 Decreased viability in esophageal squamous lineage GR00235-A 9.61 CCND1 CEACAM3 CTNNB1 KIT MYB NFIB

MGI Mouse Phenotypes related to Polymorphous Low-Grade Adenocarcinoma:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.25 ACTC1 CCND1 CTNNB1 KIT LGALS3 MYB
2 cellular MP:0005384 10.24 ACTC1 CCND1 CTNNB1 KIT LGALS3 MYB
3 behavior/neurological MP:0005386 10.22 CCND1 CTNNB1 KIT LGALS3 NTRK3 S100A1
4 growth/size/body region MP:0005378 10.2 ACTC1 CCND1 CTNNB1 KIT LGALS3 MYB
5 homeostasis/metabolism MP:0005376 10.17 ACTC1 CCND1 CTNNB1 KIT LGALS3 MYH11
6 mortality/aging MP:0010768 10.15 ACTC1 CCND1 CTNNB1 KIT LGALS3 MYB
7 digestive/alimentary MP:0005381 10.02 CCND1 CTNNB1 KIT LGALS3 MYH11 NFIB
8 integument MP:0010771 10.01 CCND1 CTNNB1 KIT LGALS3 MYB MYH11
9 normal MP:0002873 9.9 ACTC1 CCND1 CTNNB1 KIT MKI67 MYB
10 muscle MP:0005369 9.87 ACTC1 CTNNB1 KIT MYH11 S100A1 TP63
11 no phenotypic analysis MP:0003012 9.8 CTNNB1 KIT MKI67 MYB NTRK3 SERPINB5
12 respiratory system MP:0005388 9.65 CCND1 CTNNB1 KIT LGALS3 MYH11 NFIB
13 vision/eye MP:0005391 9.17 CCND1 CTNNB1 KIT NFIB NTRK3 TP63

Drugs & Therapeutics for Polymorphous Low-Grade Adenocarcinoma

Drugs for Polymorphous Low-Grade Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 2 95058-81-4 60750
2 Antiviral Agents Phase 2
3 Anti-Infective Agents Phase 2
4 Antimetabolites, Antineoplastic Phase 2
5 Immunologic Factors Phase 2
6 Antimetabolites Phase 2
7 Immunosuppressive Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gemcitabine in Treating Patients With Advanced Salivary Gland Cancer That Cannot Be Removed During Surgery Completed NCT00003744 Phase 2 gemcitabine

Search NIH Clinical Center for Polymorphous Low-Grade Adenocarcinoma

Genetic Tests for Polymorphous Low-Grade Adenocarcinoma

Anatomical Context for Polymorphous Low-Grade Adenocarcinoma

MalaCards organs/tissues related to Polymorphous Low-Grade Adenocarcinoma:

41
Salivary Gland, Tongue, Lung, Pituitary, Tonsil, Smooth Muscle, Kidney

Publications for Polymorphous Low-Grade Adenocarcinoma

Articles related to Polymorphous Low-Grade Adenocarcinoma:

(show top 50) (show all 176)
# Title Authors Year
1
Factors that may influence polymorphous low-grade adenocarcinoma growth. ( 28188441 )
2017
2
Polymorphous Low Grade Adenocarcinoma of Hard Palate: AHistopathological Pictorial. ( 29056135 )
2017
3
Establishment of a primary culture of polymorphous low grade adenocarcinoma cells. ( 28647648 )
2017
4
Advancing toward a molecular characterization of polymorphous low grade adenocarcinoma. ( 28939261 )
2017
5
Diagnostic utility of C-kit protein (CD117) expression in differentiating adenoid cystic carcinoma and polymorphous low grade Adenocarcinoma. ( 29492062 )
2017
6
Polymorphous Low Grade Adenocarcinoma of the Parotid in a Teenager. ( 28955679 )
2017
7
Predictors of Outcome in the Phenotypic Spectrum of Polymorphous Low-grade Adenocarcinoma (PLGA) and Cribriform Adenocarcinoma of Salivary Gland (CASG): A Retrospective Study of 69 Patients. ( 27454943 )
2016
8
Cribriform adenocarcinoma of minor salivary gland: A mimic of polymorphous low-grade adenocarcinoma. ( 27721624 )
2016
9
Polymorphous low-grade adenocarcinoma of the epiglottis: A case report. ( 27123278 )
2016
10
Mammaglobin and DOG-1 expression in polymorphous low-grade adenocarcinoma: an appraisal of its origin and morphology. ( 27591391 )
2016
11
Plasmacytoid-Type Cellular Differentiation in Polymorphous Low-Grade Adenocarcinoma. ( 26912473 )
2016
12
Polymorphous low-grade adenocarcinoma: A Danish national study. ( 27016011 )
2016
13
Polymorphous Low-Grade Adenocarcinoma of the Palate: A Rare Case Report. ( 27366306 )
2016
14
Polymorphous low grade adenocarcinoma. ( 26097312 )
2015
15
Histopathological spectrum of polymorphous low-grade adenocarcinoma. ( 26604510 )
2015
16
Doing more with less: the challenging diagnosis of polymorphous low-grade adenocarcinoma in incisional biopsy samples. ( 26408830 )
2015
17
Immunoexpression of growth factors and receptors in polymorphous low-grade adenocarcinoma. ( 26671844 )
2015
18
Polymorphous low-grade adenocarcinoma of the upper lip: 11 cases of an uncommon diagnosis. ( 25747177 )
2015
19
Polymorphous Low Grade Adenocarcinoma of Retromolar Region - A Rare Case Report with Distinct Clinical Manifestations. ( 26266226 )
2015
20
Polymorphous low-grade adenocarcinoma of the tongue base treated by transoral robotic surgery. ( 25954561 )
2015
21
A case report of a pulmonary metastasis of a polymorphous low-grade adenocarcinoma. ( 25693921 )
2015
22
Polymorphous low-grade adenocarcinoma of the head and neck: A population-based study of 460 cases. ( 25877006 )
2015
23
Polymorphous low grade adenocarcinoma of lip clinically mimicking squamous cell carcinoma: An unusual presentation. ( 25948951 )
2015
24
Polymorphous Low-Grade Adenocarcinoma of the Oral Cavity. ( 26413969 )
2015
25
Case report of polymorphous low-grade adenocarcinoma in the trachea with metastasis to the right middle lobe bronchus. ( 26273362 )
2015
26
Polymorphous Low Grade Adenocarcinoma has a Consistent p63+/p40- Immunophenotype that Helps Distinguish it from Adenoid Cystic Carcinoma and Cellular Pleomorphic Adenoma. ( 24969705 )
2014
27
Polymorphous low-grade adenocarcinoma: A case series and determination of recurrence. ( 25229805 )
2014
28
Polymorphous low-grade adenocarcinoma. ( 24452888 )
2014
29
Oral and maxillofacial pathology. Case of the month. Polymorphous low-grade adenocarcinoma. ( 25163215 )
2014
30
Immunohistochemical pattern of pleomorphic adenoma, polymorphous low grade adenocarcinoma and adenoid cystic carcinoma in minor salivary glands. ( 24910675 )
2014
31
Surface Papillary Epithelial Hyperplasia (Rough Mucosa) is a Helpful Clue for Identification of Polymorphous Low-Grade Adenocarcinoma. ( 25322702 )
2014
32
Polymorphous low-grade adenocarcinoma of the head and neck. ( 23428952 )
2014
33
PRKD1 mutations characterize salivary gland polymorphous low-grade adenocarcinoma. ( 25367945 )
2014
34
Polymorphous low-grade adenocarcinoma of the maxillary sinus. ( 23714964 )
2013
35
Immunohistochemical clue for the histological overlap of salivary adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. ( 24265903 )
2013
36
Polymorphous Low-Grade Adenocarcinoma (PLGA) in an 18-Year-Old Male. ( 24426416 )
2013
37
Polymorphous low-grade adenocarcinoma: an analysis of epidemiological studies and hints for pathologists. ( 23320410 )
2013
38
Expression and localization of osteopontin, homing cell adhesion molecule/CD44, and integrin I+vI^3 in pleomorphic adenoma, polymorphous low-grade adenocarcinoma, and adenoid cystic carcinoma. ( 24237725 )
2013
39
Polymorphous low-grade adenocarcinoma of maxillary alveolus metastasising to the abdomen: the role of immunomarkers in diagnosis. ( 23661663 )
2013
40
Polymorphous low-grade adenocarcinoma: a case report. ( 22184472 )
2013
41
Polymorphous low-grade adenocarcinoma of the upper lip with metachronous myoepithelioma of the buccal mucosa. ( 24268388 )
2013
42
Polymorphous low-grade adenocarcinoma of the larynx: a rare case report. ( 23981163 )
2013
43
Polymorphous low-grade adenocarcinoma--management and reconstruction with temporalis myofacial flap. ( 24431823 )
2013
44
Polymorphous low-grade adenocarcinoma in the upper lip: a well-described but infrequently recognized tumor. ( 24021444 )
2013
45
Polymorphous low-grade adenocarcinoma: a 17 patient case series. ( 23618791 )
2013
46
Cytomorphological features of an aggressive variant of polymorphous low-grade adenocarcinoma in adolescence with lymph node metastasis. ( 22144102 )
2013
47
Fine needle aspiration cytology of metastatic polymorphous low-grade adenocarcinoma of the palate in a cervical lymph node. ( 21883542 )
2013
48
Proton beam therapy and continuous intra-arterial chemotherapy for polymorphous low-grade adenocarcinoma in the hard palate. ( 23466803 )
2013
49
Intraosseous polymorphous low-grade adenocarcinoma of mandible: A rare entity. ( 23162596 )
2012
50
Polymorphous low-grade adenocarcinoma located in the maxillary sinus. ( 23011832 )
2012

Variations for Polymorphous Low-Grade Adenocarcinoma

Expression for Polymorphous Low-Grade Adenocarcinoma

Search GEO for disease gene expression data for Polymorphous Low-Grade Adenocarcinoma.

Pathways for Polymorphous Low-Grade Adenocarcinoma

GO Terms for Polymorphous Low-Grade Adenocarcinoma

Biological processes related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.72 CCND1 CTNNB1 KIT NTRK3 S100B
2 cytokine-mediated signaling pathway GO:0019221 9.71 CCND1 KIT MUC1 VIM
3 response to ethanol GO:0045471 9.63 ACTC1 CCND1 NTRK3
4 response to corticosterone GO:0051412 9.48 CCND1 NTRK3
5 positive regulation of histone H3-K4 methylation GO:0051571 9.43 CTNNB1 MYB
6 negative regulation of transcription by RNA polymerase II GO:0000122 9.43 CCND1 CTNNB1 MYB NFIB S100A1 TP63
7 positive regulation of phospholipase C activity GO:0010863 9.37 KIT NTRK3
8 regulation of T cell proliferation GO:0042129 9.26 CTNNB1 LGALS3
9 cranial skeletal system development GO:1904888 9.16 CTNNB1 TP63
10 positive regulation of gene expression GO:0010628 9.02 ACTC1 CTNNB1 KIT NTRK3 VIM

Molecular functions related to Polymorphous Low-Grade Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 S100 protein binding GO:0044548 8.96 S100A1 S100B
2 p53 binding GO:0002039 8.8 MUC1 NTRK3 TP63

Sources for Polymorphous Low-Grade Adenocarcinoma

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9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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36 IUPHAR
37 KEGG
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44 MeSH
45 MESH via Orphanet
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62 PubMed
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69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
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74 UMLS via Orphanet
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