MCID: PLY008
MIFTS: 19

Polyneuropathy Due to Drug

Categories: Neuronal diseases

Aliases & Classifications for Polyneuropathy Due to Drug

MalaCards integrated aliases for Polyneuropathy Due to Drug:

Name: Polyneuropathy Due to Drug 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:14184
ICD9CM 34 357.6
SNOMED-CT 67 7339009
ICD10 32 G62.0
UMLS 71 C0154762

Summaries for Polyneuropathy Due to Drug

MalaCards based summary : Polyneuropathy Due to Drug is related to inflammatory and toxic neuropathy and sister chromatid exchange, frequency of. An important gene associated with Polyneuropathy Due to Drug is RPRD1B (Regulation Of Nuclear Pre-MRNA Domain Containing 1B), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. Related phenotype is homeostasis/metabolism.

Related Diseases for Polyneuropathy Due to Drug

Diseases in the Polyneuropathy family:

Polyneuropathy Due to Drug Chronic Polyneuropathy

Diseases related to Polyneuropathy Due to Drug via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 inflammatory and toxic neuropathy 10.2 RPRD1B MIDN
2 sister chromatid exchange, frequency of 10.0 EPHX1 CYP2E1
3 acetaminophen metabolism 10.0 GSTP1 CYP2E1
4 liver benign neoplasm 9.9 GSTP1 CYP2E1
5 maturity-onset diabetes of the young, type 2 9.9 WFS1 HNF4A
6 testicular cancer 9.8 SLC22A2 GSTP1 ERCC1 ACYP2
7 tobacco addiction 9.6 GSTP1 EPHX1 CYP2E1 COMT
8 childhood acute lymphocytic leukemia 9.6 TPMT GSTP1 CYP2E1

Graphical network of the top 20 diseases related to Polyneuropathy Due to Drug:



Diseases related to Polyneuropathy Due to Drug

Symptoms & Phenotypes for Polyneuropathy Due to Drug

MGI Mouse Phenotypes related to Polyneuropathy Due to Drug:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.47 ABCG2 COMT CYP2E1 EPHX1 ERCC1 FIGN

Drugs & Therapeutics for Polyneuropathy Due to Drug

Search Clinical Trials , NIH Clinical Center for Polyneuropathy Due to Drug

Genetic Tests for Polyneuropathy Due to Drug

Anatomical Context for Polyneuropathy Due to Drug

Publications for Polyneuropathy Due to Drug

Variations for Polyneuropathy Due to Drug

Expression for Polyneuropathy Due to Drug

Search GEO for disease gene expression data for Polyneuropathy Due to Drug.

Pathways for Polyneuropathy Due to Drug

Pathways related to Polyneuropathy Due to Drug according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 TPMT THEM5 SLC22A2 HS3ST3A1 HPGDS GSTP1
2
Show member pathways
12.92 TPMT HS3ST3A1 HPGDS GSTP1 EPHX1 CYP2E1
3
Show member pathways
12.62 TPMT HPGDS GSTP1 EPHX1 CYP2E1
4 12.3 WFS1 SLC31A1 HNF4A ABCG2
5 11.52 SLC31A1 GSTP1 ERCC1
6
Show member pathways
11.42 EPHX1 CYP2E1 COMT
7
Show member pathways
11.38 SLC22A2 CYP2E1 COMT ABCG2
8
Show member pathways
11.15 GSTP1 EPHX1 CYP2E1 ABCG2
9
Show member pathways
10.97 SLC22A2 COMT
10 10.88 GSTP1 EPHX1 CYP2E1
11 10.86 CYP2E1 ABCG2
12
Show member pathways
10.85 SLC22A2 ABCG2
13 10.79 SLC22A2 ABCG2
14 10.79 GSTP1 EPHX1 ABCG2
15
Show member pathways
10.75 TPMT COMT
16 10.39 SLC31A1 GSTP1 ERCC1 ABCG2
17 10.36 HNF4A CYP2E1
18 10.18 EPHX1 CYP2E1

GO Terms for Polyneuropathy Due to Drug

Biological processes related to Polyneuropathy Due to Drug according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug metabolic process GO:0017144 9.37 TPMT CYP2E1
2 xenobiotic transport GO:0042908 9.32 SLC22A2 ABCG2
3 glutathione derivative biosynthetic process GO:1901687 9.26 HPGDS GSTP1
4 export across plasma membrane GO:0140115 9.16 SLC22A2 ABCG2
5 drug transport across blood-brain barrier GO:1990962 8.96 SLC22A2 ABCG2
6 xenobiotic metabolic process GO:0006805 8.92 HNF4A GSTP1 EPHX1 CYP2E1

Molecular functions related to Polyneuropathy Due to Drug according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fatty acid binding GO:0005504 9.26 HNF4A GSTP1
2 glutathione transferase activity GO:0004364 9.16 HPGDS GSTP1
3 xenobiotic transmembrane transporter activity GO:0042910 8.96 SLC22A2 ABCG2
4 efflux transmembrane transporter activity GO:0015562 8.62 SLC22A2 ABCG2

Sources for Polyneuropathy Due to Drug

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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