Polyneuropathy Due to Drug disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Polyneuropathy Due to Drug

MalaCards integrated aliases for Polyneuropathy Due to Drug:

Name: Polyneuropathy Due to Drug ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the nervous system

Polyneuropathies and other disorders of the peripheral nervous system

Other polyneuropathies

Drug-induced polyneuropathy

External Ids:

Disease Ontology ¹² DOID:14184

ICD9CM ³⁴ 357.6

SNOMED-CT ⁶⁷ 7339009

ICD10 ³² G62.0

UMLS ⁷¹ C0154762

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Summaries for Polyneuropathy Due to Drug

MalaCards based summary : Polyneuropathy Due to Drug is related to inflammatory and toxic neuropathy and sister chromatid exchange, frequency of. An important gene associated with Polyneuropathy Due to Drug is RPRD1B (Regulation Of Nuclear Pre-MRNA Domain Containing 1B), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. Related phenotype is homeostasis/metabolism.

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Related Diseases for Polyneuropathy Due to Drug

Diseases in the Polyneuropathy family:

Polyneuropathy Due to Drug

Chronic Polyneuropathy

Diseases related to Polyneuropathy Due to Drug via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	inflammatory and toxic neuropathy	10.2	RPRD1B MIDN
2	sister chromatid exchange, frequency of	10.0	EPHX1 CYP2E1
3	acetaminophen metabolism	10.0	GSTP1 CYP2E1
4	liver benign neoplasm	9.9	GSTP1 CYP2E1
5	maturity-onset diabetes of the young, type 2	9.9	WFS1 HNF4A
6	testicular cancer	9.8	SLC22A2 GSTP1 ERCC1 ACYP2
7	tobacco addiction	9.6	GSTP1 EPHX1 CYP2E1 COMT
8	childhood acute lymphocytic leukemia	9.6	TPMT GSTP1 CYP2E1

Graphical network of the top 20 diseases related to Polyneuropathy Due to Drug:

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Symptoms & Phenotypes for Polyneuropathy Due to Drug

MGI Mouse Phenotypes related to Polyneuropathy Due to Drug:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.47	ABCG2 COMT CYP2E1 EPHX1 ERCC1 FIGN

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Drugs & Therapeutics for Polyneuropathy Due to Drug

Search Clinical Trials , NIH Clinical Center for Polyneuropathy Due to Drug

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Genetic Tests for Polyneuropathy Due to Drug

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Anatomical Context for Polyneuropathy Due to Drug

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Publications for Polyneuropathy Due to Drug

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Genes for Polyneuropathy Due to Drug

Genes related to Polyneuropathy Due to Drug (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	RPRD1B	Regulation Of Nuclear Pre-MRNA Domain Containing 1B	Protein Coding	7.89	DISEASES inferred ¹⁵
2	THEM5	Thioesterase Superfamily Member 5	Protein Coding	6.43	DISEASES inferred ¹⁵
3	MIDN	Midnolin	Protein Coding	6.35	DISEASES inferred ¹⁵
4	HS3ST3A1	Heparan Sulfate-Glucosamine 3-Sulfotransferase 3A1	Protein Coding	5.85	DISEASES inferred ¹⁵
5	FIGN	Fidgetin, Microtubule Severing Factor	Protein Coding	5.79	DISEASES inferred ¹⁵
6	ACYP2	Acylphosphatase 2	Protein Coding	5.56	DISEASES inferred ¹⁵
7	ATP8A2	ATPase Phospholipid Transporting 8A2	Protein Coding	5.49	DISEASES inferred ¹⁵
8	EPHA5	EPH Receptor A5	Protein Coding	4.98	DISEASES inferred ¹⁵
9	SLC31A1	Solute Carrier Family 31 Member 1	Protein Coding	4.96	DISEASES inferred ¹⁵
10	SLC22A2	Solute Carrier Family 22 Member 2	Protein Coding	4.76	DISEASES inferred ¹⁵
11	EPHX1	Epoxide Hydrolase 1	Protein Coding	4.6	DISEASES inferred ¹⁵
12	ERCC1	ERCC Excision Repair 1, Endonuclease Non-Catalytic Subunit	Protein Coding	4.58	DISEASES inferred ¹⁵
13	GSTP1	Glutathione S-Transferase Pi 1	Protein Coding	4.47	DISEASES inferred ¹⁵
14	TPMT	Thiopurine S-Methyltransferase	Protein Coding	4.41	DISEASES inferred ¹⁵
15	WFS1	Wolframin ER Transmembrane Glycoprotein	Protein Coding	4.37	DISEASES inferred ¹⁵
16	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	3.73	DISEASES inferred ¹⁵
17	COMT	Catechol-O-Methyltransferase	Protein Coding	3.69	DISEASES inferred ¹⁵
18	HPGDS	Hematopoietic Prostaglandin D Synthase	Protein Coding	3.45	DISEASES inferred ¹⁵
19	ABCG2	ATP Binding Cassette Subfamily G Member 2 (Junior Blood Group)	Protein Coding	3.43	DISEASES inferred ¹⁵
20	HNF4A	Hepatocyte Nuclear Factor 4 Alpha	Protein Coding	3.32	DISEASES inferred ¹⁵

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Variations for Polyneuropathy Due to Drug

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Expression for Polyneuropathy Due to Drug

Search GEO for disease gene expression data for Polyneuropathy Due to Drug.

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Pathways for Polyneuropathy Due to Drug

Pathways related to Polyneuropathy Due to Drug according to GeneCards Suite gene sharing:

(show all 18)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism ⁶⁵ Show member pathways Metabolic pathways ³⁶ Metabolism of lipids and lipoproteins ⁶⁵	13.96	TPMT THEM5 SLC22A2 HS3ST3A1 HPGDS GSTP1
2	Cytochrome P450 - arranged by substrate type ⁶⁵ Show member pathways Amine Oxidase reactions ⁶⁵ Aryl hydrocarbon receptor signalling ⁶⁵ Benzo(a)pyrene metabolism ¹ Biological oxidations ⁶⁵ bupropion degradation ¹ Cannabidiol Pathway, Pharmacokinetics ⁶⁰ CYP2E1 reactions ⁶⁵ Cytosolic sulfonation of small molecules ⁶⁵ Doxepin Pathway, Pharmacokinetics ⁶⁰ Eicosanoids ⁶⁵ Endogenous sterols ⁶⁵ Estradiol metabolism ²³ Ethanol oxidation ⁶⁵ Fatty Acid Omega Oxidation ¹ Fatty acids ⁶⁵ Fluoxetine Pathway, Pharmacokinetics ⁶⁰ Lidocaine Pathway, Pharmacokinetics ⁶⁰ Metapathway biotransformation ¹ Methylation ⁶⁵ Methylphenidate Pathway, Pharmacokinetics ⁶⁰ Miscellaneous substrates ⁶⁵ Oxidation by Cytochrome P450 ¹ Phase 1 - Functionalization of compounds ⁶⁵ Phase II conjugation ⁶⁵ Sterols are 12-hydroxylated by CYP8B1 ⁶⁵ Transport and synthesis of PAPS ⁶⁵ Vitamin D2 (ergocalciferol) metabolism ²³ vitamin D3 biosynthesis ¹ Vitamins ⁶⁵ Xenobiotics ⁶⁵	12.92	TPMT HS3ST3A1 HPGDS GSTP1 EPHX1 CYP2E1
3	Drug metabolism - cytochrome P450 ³⁶ Show member pathways Aflatoxin B1 metabolism ¹ Artemisinin and Derivatives Pathway, Pharmacokinetics ⁶⁰ Arylamine metabolism ¹ Benzo[a]pyrene metabolism ²³ Benzodiazepine Pathway, Pharmacokinetics ⁶⁰ Celecoxib Pathway, Pharmacokinetics ⁶⁰ Chemical carcinogenesis ³⁶ Drug metabolism - other enzymes ³⁶ Fluvoxamine Pathway, Pharmacokinetics ⁶⁰ Haloperidol Pathway, Pharmacokinetics ⁶⁰ Ifosfamide Pathway, Pharmacokinetics ⁶⁰ Metabolism of xenobiotics by cytochrome P450 ³⁶ Naproxen Pathway, Pharmacokinetics ⁶⁰ Nicotine Metabolism ¹ Nicotine Pathway, Pharmacokinetics ⁶⁰ Retinol metabolism ³⁶ Retinol metabolism ²³ Sertraline Pathway, Pharmacokinetics ⁶⁰ Voriconazole Pathway, Pharmacokinetics ⁶⁰	12.62	TPMT HPGDS GSTP1 EPHX1 CYP2E1
4	Glucose / Energy Metabolism ⁴	12.3	WFS1 SLC31A1 HNF4A ABCG2
5	Platinum drug resistance ³⁶	11.52	SLC31A1 GSTP1 ERCC1
6	Phenytoin Pathway, Pharmacokinetics ⁶⁰ Show member pathways Atomoxetine Pathway, Pharmacokinetics ⁶⁰ Carbamazepine Pathway, Pharmacokinetics ⁶⁰ Cyclophosphamide Pathway, Pharmacokinetics ⁶⁰ Efavirenz Pathway, Pharmacokinetics ⁶⁰ Sorafenib Pharmacokinetics ⁶⁰	11.42	EPHX1 CYP2E1 COMT
7	Paroxetine Pathway, Pharmacokinetics ⁶⁰ Show member pathways Amitriptyline and Nortriptyline Pathway, Pharmacokinetics ⁶⁰ Candesartan Pathway, Pharmacokinetics ⁶⁰ Citalopram Pathway, Pharmacokinetics ⁶⁰ Clomipramine Pathway, Pharmacokinetics ⁶⁰ Clozapine Pathway, Pharmacokinetics ⁶⁰ Imipramine/Desipramine Pathway, Pharmacokinetics ⁶⁰ Olanzapine Pathway, Pharmacokinetics ⁶⁰ Proton Pump Inhibitor Pathway, Pharmacokinetics ⁶⁰ Venlafaxine Pathway, Pharmacokinetics ⁶⁰ Verapamil Pathway, Pharmacokinetics ⁶⁰ Warfarin Pathway, Pharmacokinetics ⁶⁰	11.38	SLC22A2 CYP2E1 COMT ABCG2
8	Acetaminophen Pathway (therapeutic doses), Pharmacokinetics ⁶⁰ Show member pathways 2-Naphthylamine and 2-Nitronaphtalene metabolism ²³ Acetaminophen metabolism ²³ Acetaminophen Pathway (toxic doses), Pharmacokinetics ⁶⁰	11.15	GSTP1 EPHX1 CYP2E1 ABCG2
9	Neurotransmitter Clearance In The Synaptic Cleft ⁶⁵ Show member pathways Dopamine clearance from the synaptic cleft ⁶⁵ Enzymatic degradation of dopamine by COMT ⁶⁵ Enzymatic degradation of Dopamine by monoamine oxidase ⁶⁵ Metabolism of serotonin ⁶⁵ Serotonin clearance from the synaptic cleft ⁶⁵	10.97	SLC22A2 COMT
10	Naphthalene metabolism ²³	10.88	GSTP1 EPHX1 CYP2E1
11	Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.86	CYP2E1 ABCG2
12	Abacavir transport and metabolism ⁶⁵ Show member pathways Abacavir metabolism ⁶⁵ Abacavir transmembrane transport ⁶⁵	10.85	SLC22A2 ABCG2
13	Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.79	SLC22A2 ABCG2
14	Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling ¹	10.79	GSTP1 EPHX1 ABCG2
15	Methylation Pathways ¹ Show member pathways methionine degradation ¹ Methylation of MeSeH for excretion ⁶⁵ S-adenosyl-L-methionine biosynthesis ¹	10.75	TPMT COMT
16	Platinum Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.39	SLC31A1 GSTP1 ERCC1 ABCG2
17	Dichloroethylene metabolism ²³	10.36	HNF4A CYP2E1
18	Benzene metabolism ¹	10.18	EPHX1 CYP2E1

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GO Terms for Polyneuropathy Due to Drug

Biological processes related to Polyneuropathy Due to Drug according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	drug metabolic process	GO:0017144	9.37	TPMT CYP2E1
2	xenobiotic transport	GO:0042908	9.32	SLC22A2 ABCG2
3	glutathione derivative biosynthetic process	GO:1901687	9.26	HPGDS GSTP1
4	export across plasma membrane	GO:0140115	9.16	SLC22A2 ABCG2
5	drug transport across blood-brain barrier	GO:1990962	8.96	SLC22A2 ABCG2
6	xenobiotic metabolic process	GO:0006805	8.92	HNF4A GSTP1 EPHX1 CYP2E1

Molecular functions related to Polyneuropathy Due to Drug according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	fatty acid binding	GO:0005504	9.26	HNF4A GSTP1
2	glutathione transferase activity	GO:0004364	9.16	HPGDS GSTP1
3	xenobiotic transmembrane transporter activity	GO:0042910	8.96	SLC22A2 ABCG2
4	efflux transmembrane transporter activity	GO:0015562	8.62	SLC22A2 ABCG2

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