BKVN
MCID: PLY043
MIFTS: 13

Polyomavirus Allograft Nephropathy (BKVN)

Categories: Nephrological diseases, Rare diseases

Aliases & Classifications for Polyomavirus Allograft Nephropathy

MalaCards integrated aliases for Polyomavirus Allograft Nephropathy:

Name: Polyomavirus Allograft Nephropathy 52
Polyomavirus-Related Transplant Nephropathy 52
Bkvn 52

Classifications:



Summaries for Polyomavirus Allograft Nephropathy

MalaCards based summary : Polyomavirus Allograft Nephropathy, also known as polyomavirus-related transplant nephropathy, is related to polyomavirus-associated nephropathy and bk-virus nephropathy. The drugs Clotrimazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include kidney.

Related Diseases for Polyomavirus Allograft Nephropathy

Diseases related to Polyomavirus Allograft Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 polyomavirus-associated nephropathy 10.3
2 bk-virus nephropathy 10.3
3 acute kidney failure 10.0

Symptoms & Phenotypes for Polyomavirus Allograft Nephropathy

Drugs & Therapeutics for Polyomavirus Allograft Nephropathy

Drugs for Polyomavirus Allograft Nephropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
2
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
3
Everolimus Approved Phase 4 159351-69-6 70789204 6442177
4
Mycophenolic acid Approved Phase 4 24280-93-1 446541
5 Antitubercular Agents Phase 4
6 Anti-Bacterial Agents Phase 4
7 Antifungal Agents Phase 4
8 Dermatologic Agents Phase 4
9 Antibiotics, Antitubercular Phase 4
10 Antirheumatic Agents Phase 4
11 Immunologic Factors Phase 4
12 Immunosuppressive Agents Phase 4
13 Cyclosporins Phase 4
14
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492 6473866
15
Cidofovir Approved Phase 1, Phase 2 113852-37-2 60613
16 Calcineurin Inhibitors Phase 2
17 Anti-Infective Agents Phase 1, Phase 2
18 Pharmaceutical Solutions Phase 1, Phase 2
19 Antiviral Agents Phase 1, Phase 2
20
Leflunomide Approved, Investigational 75706-12-6 3899
21
Methylprednisolone Approved, Vet_approved 83-43-2 6741
22
Prednisolone phosphate Approved, Vet_approved 302-25-0
23
Methylprednisolone hemisuccinate Approved 2921-57-5
24
Prednisolone Approved, Vet_approved 50-24-8 5755
25 Prednisolone acetate Approved, Vet_approved 52-21-1
26
Prednisolone hemisuccinate Experimental 2920-86-7
27 Antibodies
28 Antibodies, Blocking
29 Immunoglobulins
30 Methylprednisolone Acetate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective Randomized Study to Characterize Risk Factors of Polyomavirus-related Transplant Nephropathy and the Impact of Three Immunosuppressive Regimens on Nephropathy Incidence Completed NCT00160966 Phase 4 Ciclosporin and Mycophenolate-mofetil;Tacrolimus and Mycophenolate-mofetil;Tacrolimus and Mycophenolate-mofetil with change from Mycophenolate-mofetil to Everolimus
2 Multicenter Randomized Two-arms Study Evaluating the BK Viral Clearance in Kidney Transplant Recipients With BK Viremia After Reduction of Immunosuppression Alone vs. Reduction of Immunosuppression and Replacement of Mycophenolate Mofetil by Everolimus Recruiting NCT03216967 Phase 4 everolimus
3 Conversion From Tacrolimus to Envarsus in Rapid Metabolizers Post Kidney Transplant Protects Against BK Infection Recruiting NCT03762473 Phase 2 Study Group;Control Group
4 A Randomized, Placebo-Controlled, Dose-Escalation Study to Assess the Safety and Effect of Cidofovir in Renal Transplant Recipients With BK Virus Nephropathy Terminated NCT00138424 Phase 1, Phase 2 Cidofovir;Placebo
5 Role of Anti-BK Virus Neutralizing Antibodies (BKV) as a Prognostic Marker for the Development of Nephropathy BK Unknown status NCT02826811
6 BK Viremia After Renal Transplantation: Screening, Early Diagnosis, Early Reduction in Immunosuppression and Treatment With Leflunomide (Arava) Unknown status NCT00684372 leflunomide
7 Natural History of Infection Caused by BK Virus (and Other Opportunistic Viral Pathogens) in Renal Transplant Recipients Completed NCT01782209
8 Validating Injury to Renal Transplant Using Urinary Signatures in Children Active, not recruiting NCT03719339

Search NIH Clinical Center for Polyomavirus Allograft Nephropathy

Genetic Tests for Polyomavirus Allograft Nephropathy

Anatomical Context for Polyomavirus Allograft Nephropathy

MalaCards organs/tissues related to Polyomavirus Allograft Nephropathy:

40
Kidney

Publications for Polyomavirus Allograft Nephropathy

Articles related to Polyomavirus Allograft Nephropathy:

# Title Authors PMID Year
1
A very early and acute renal impairment due to polyomavirus allograft nephropathy. 61
20604905 2010
2
Clinical utility of histological features of polyomavirus allograft nephropathy. 61
16858282 2006
3
Latent and productive polyomavirus infections of renal allografts: morphological, clinical, and pathophysiological aspects. 61
16626037 2006
4
Negative impact of human leukocyte antigen matching in the outcome of polyomavirus nephropathy. 61
16041275 2005
5
Cost efficiency in the prospective diagnosis and follow-up of polyomavirus allograft nephropathy. 61
15686687 2004
6
Polyomavirus allograft nephropathy and concurrent acute rejection: a diagnostic and therapeutic challenge. 61
15084184 2004
7
Polyomavirus allograft nephropathy: sequential assessment of histologic viral load, tubulitis, and graft function following changes in immunosuppression. 61
14525598 2003

Variations for Polyomavirus Allograft Nephropathy

Expression for Polyomavirus Allograft Nephropathy

Search GEO for disease gene expression data for Polyomavirus Allograft Nephropathy.

Pathways for Polyomavirus Allograft Nephropathy

GO Terms for Polyomavirus Allograft Nephropathy

Sources for Polyomavirus Allograft Nephropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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