BKVN
MCID: PLY043
MIFTS: 13

Polyomavirus Allograft Nephropathy (BKVN)

Categories: Nephrological diseases, Rare diseases

Aliases & Classifications for Polyomavirus Allograft Nephropathy

MalaCards integrated aliases for Polyomavirus Allograft Nephropathy:

Name: Polyomavirus Allograft Nephropathy 52
Polyomavirus-Related Transplant Nephropathy 52
Bkvn 52

Classifications:



Summaries for Polyomavirus Allograft Nephropathy

MalaCards based summary : Polyomavirus Allograft Nephropathy, also known as polyomavirus-related transplant nephropathy, is related to polyomavirus-associated nephropathy and bk-virus nephropathy. The drugs Sirolimus and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include kidney.

Related Diseases for Polyomavirus Allograft Nephropathy

Diseases related to Polyomavirus Allograft Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 3, show less)
# Related Disease Score Top Affiliating Genes
1 polyomavirus-associated nephropathy 10.3
2 bk-virus nephropathy 10.3
3 acute kidney failure 10.0

Symptoms & Phenotypes for Polyomavirus Allograft Nephropathy

Drugs & Therapeutics for Polyomavirus Allograft Nephropathy

Drugs for Polyomavirus Allograft Nephropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 30, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
2
Everolimus Approved Phase 4 159351-69-6 6442177 70789204
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4
Mycophenolic acid Approved Phase 4 24280-93-1 446541
5 Dermatologic Agents Phase 4
6 Antirheumatic Agents Phase 4
7 Antitubercular Agents Phase 4
8 Anti-Bacterial Agents Phase 4
9 Antibiotics, Antitubercular Phase 4
10 Cyclosporins Phase 4
11 Antifungal Agents Phase 4
12 Immunosuppressive Agents Phase 4
13 Immunologic Factors Phase 4
14
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492 6473866
15
Cidofovir Approved Phase 1, Phase 2 113852-37-2 60613
16 Calcineurin Inhibitors Phase 2
17 Anti-Infective Agents Phase 1, Phase 2
18 Antiviral Agents Phase 1, Phase 2
19 Pharmaceutical Solutions Phase 1, Phase 2
20
Methylprednisolone Approved, Vet_approved 83-43-2 6741
21
Leflunomide Approved, Investigational 75706-12-6 3899
22
Prednisolone phosphate Approved, Vet_approved 302-25-0
23 Prednisolone acetate Approved, Vet_approved 52-21-1
24
Methylprednisolone hemisuccinate Approved 2921-57-5
25
Prednisolone Approved, Vet_approved 50-24-8 5755
26
Prednisolone hemisuccinate Experimental 2920-86-7
27 Antibodies
28 Immunoglobulins
29 Antibodies, Blocking
30 Methylprednisolone Acetate

Interventional clinical trials:

(showing 8, show less)
# Name Status NCT ID Phase Drugs
1 Prospective Randomized Study to Characterize Risk Factors of Polyomavirus-related Transplant Nephropathy and the Impact of Three Immunosuppressive Regimens on Nephropathy Incidence Completed NCT00160966 Phase 4 Ciclosporin and Mycophenolate-mofetil;Tacrolimus and Mycophenolate-mofetil;Tacrolimus and Mycophenolate-mofetil with change from Mycophenolate-mofetil to Everolimus
2 Multicenter Randomized Two-arms Study Evaluating the BK Viral Clearance in Kidney Transplant Recipients With BK Viremia After Reduction of Immunosuppression Alone vs. Reduction of Immunosuppression and Replacement of Mycophenolate Mofetil by Everolimus Recruiting NCT03216967 Phase 4 everolimus
3 Conversion From Tacrolimus to Envarsus in Rapid Metabolizers Post Kidney Transplant Protects Against BK Infection Recruiting NCT03762473 Phase 2 Study Group;Control Group
4 A Randomized, Placebo-Controlled, Dose-Escalation Study to Assess the Safety and Effect of Cidofovir in Renal Transplant Recipients With BK Virus Nephropathy Terminated NCT00138424 Phase 1, Phase 2 Cidofovir;Placebo
5 Role of Anti-BK Virus Neutralizing Antibodies (BKV) as a Prognostic Marker for the Development of Nephropathy BK Unknown status NCT02826811
6 BK Viremia After Renal Transplantation: Screening, Early Diagnosis, Early Reduction in Immunosuppression and Treatment With Leflunomide (Arava) Unknown status NCT00684372 leflunomide
7 Validating Injury to Renal Transplant Using Urinary Signatures in Children Recruiting NCT03719339
8 Natural History of Infection Caused by BK Virus (and Other Opportunistic Viral Pathogens) in Renal Transplant Recipients Active, not recruiting NCT01782209

Search NIH Clinical Center for Polyomavirus Allograft Nephropathy

Genetic Tests for Polyomavirus Allograft Nephropathy

Anatomical Context for Polyomavirus Allograft Nephropathy

MalaCards organs/tissues related to Polyomavirus Allograft Nephropathy:

40
Kidney

Publications for Polyomavirus Allograft Nephropathy

Articles related to Polyomavirus Allograft Nephropathy:

(showing 7, show less)
# Title Authors PMID Year
1
A very early and acute renal impairment due to polyomavirus allograft nephropathy. 61
20604905 2010
2
Clinical utility of histological features of polyomavirus allograft nephropathy. 61
16858282 2006
3
Latent and productive polyomavirus infections of renal allografts: morphological, clinical, and pathophysiological aspects. 61
16626037 2006
4
Negative impact of human leukocyte antigen matching in the outcome of polyomavirus nephropathy. 61
16041275 2005
5
Cost efficiency in the prospective diagnosis and follow-up of polyomavirus allograft nephropathy. 61
15686687 2004
6
Polyomavirus allograft nephropathy and concurrent acute rejection: a diagnostic and therapeutic challenge. 61
15084184 2004
7
Polyomavirus allograft nephropathy: sequential assessment of histologic viral load, tubulitis, and graft function following changes in immunosuppression. 61
14525598 2003

Variations for Polyomavirus Allograft Nephropathy

Expression for Polyomavirus Allograft Nephropathy

Search GEO for disease gene expression data for Polyomavirus Allograft Nephropathy.

Pathways for Polyomavirus Allograft Nephropathy

GO Terms for Polyomavirus Allograft Nephropathy

Sources for Polyomavirus Allograft Nephropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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