PVAN
MCID: PLY179
MIFTS: 24

Polyomavirus-Associated Nephropathy (PVAN)

Categories: Infectious diseases, Nephrological diseases

Aliases & Classifications for Polyomavirus-Associated Nephropathy

MalaCards integrated aliases for Polyomavirus-Associated Nephropathy:

Name: Polyomavirus-Associated Nephropathy 12 15
Polyomavirus Associated Nephropathy 12
Pvan 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0040086
SNOMED-CT 67 713886006
UMLS 71 C1697878

Summaries for Polyomavirus-Associated Nephropathy

Disease Ontology : 12 A viral infectious disease has material basis in BK polyomavirus.

MalaCards based summary : Polyomavirus-Associated Nephropathy, also known as polyomavirus associated nephropathy, is related to interstitial nephritis and end stage renal disease. An important gene associated with Polyomavirus-Associated Nephropathy is LINC01194 (Long Intergenic Non-Protein Coding RNA 1194), and among its related pathways/superpathways is Alzheimers Disease. Affiliated tissues include kidney, t cells and pancreas, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Polyomavirus-Associated Nephropathy

Diseases related to Polyomavirus-Associated Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 interstitial nephritis 10.2
2 end stage renal disease 10.2
3 bk-virus nephropathy 10.2
4 kaposi sarcoma 10.0
5 obstructive nephropathy 10.0
6 nephrosclerosis 10.0
7 transitional cell carcinoma 10.0
8 skin squamous cell carcinoma 10.0
9 arteriolosclerosis 10.0
10 48,xyyy 10.0
11 hemorrhagic cystitis 9.9 LINC01194 EPRS1 CABIN1
12 hantavirus hemorrhagic fever with renal syndrome 9.9 LINC01194 GAPDH CHADL CABIN1
13 cerebral degeneration 9.8 MAPT GAPDH EPRS1
14 specific developmental disorder 9.6 MAPT GAPDH EPRS1

Graphical network of the top 20 diseases related to Polyomavirus-Associated Nephropathy:



Diseases related to Polyomavirus-Associated Nephropathy

Symptoms & Phenotypes for Polyomavirus-Associated Nephropathy

GenomeRNAi Phenotypes related to Polyomavirus-Associated Nephropathy according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-115 9.53 NDUFB4
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.53 PPP1R8
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.53 NFATC3
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-146 9.53 PPP1R8
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-158 9.53 PPP1R8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-170 9.53 NFATC3
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.53 NDUFB4
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-189 9.53 NDUFB4
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.53 NFATC3
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-198 9.53 NDUFB4
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.53 NDUFB4
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-31 9.53 PPP1R8
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-54 9.53 PPP1R8
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.53 NDUFB4
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-78 9.53 PPP1R8
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-96 9.53 PPP1R8

Drugs & Therapeutics for Polyomavirus-Associated Nephropathy

Search Clinical Trials , NIH Clinical Center for Polyomavirus-Associated Nephropathy

Genetic Tests for Polyomavirus-Associated Nephropathy

Anatomical Context for Polyomavirus-Associated Nephropathy

MalaCards organs/tissues related to Polyomavirus-Associated Nephropathy:

40
Kidney, T Cells, Pancreas, Heart, Testes, Bone Marrow, Bone

Publications for Polyomavirus-Associated Nephropathy

Articles related to Polyomavirus-Associated Nephropathy:

(show top 50) (show all 253)
# Title Authors PMID Year
1
Significance of revised criteria for chronic active T cell-mediated rejection in the 2017 Banff classification: Surveillance by 1-year protocol biopsies for kidney transplantation. 61
32484280 2020
2
BK Virus RNA in Renal Allograft Biopsies. 61
32352851 2020
3
Longitudinal assessment of the CXCL10 blood and urine concentration in kidney transplant recipients with BK polyomavirus replication-a retrospective study. 61
31981424 2020
4
Possibility of BKV-Associated Nephropathy in Hospitalized Burn Patients. 61
31867602 2020
5
Immunosuppression, BK polyomavirus infections, and BK polyomavirus-specific T cells after pediatric kidney transplantation. 61
31858227 2020
6
Low-dose cidofovir and conversion to mTOR-based immunosuppression in polyomavirus-associated nephropathy. 61
31797495 2020
7
Non-invasive urinary sediment double-immunostaining predicts BK polyomavirus associated-nephropathy in kidney transplant recipients. 61
32309382 2020
8
Mitral chordae tendineae force profile characterization using a posterior ventricular anchoring neochordal repair model for mitral regurgitation in a three-dimensional-printed ex vivo left heart simulator. 61
31638697 2020
9
BK Polyomavirus-associated nephropathy managed by screening policy in a real-life setting. 61
31724282 2020
10
Use of intravenous immunoglobulin in a highly sensitized pediatric renal transplant recipient with severe BK DNAemia and rising DSA. 61
31657100 2020
11
Next-generation sequencing shows marked rearrangements of BK polyomavirus that favor but are not required for polyomavirus-associated nephropathy. 61
31783265 2020
12
Early fulminant BK polyomavirus-associated nephropathy in two kidney transplant patients with low neutralizing antibody titers receiving allografts from the same donor. 61
31924245 2020
13
Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys. 61
31971979 2020
14
Pathogenicity of BK virus on the urinary system. 61
32395331 2020
15
A Multicenter Application of the 2018 Banff Classification for BK Polyomavirus-associated Nephropathy in Renal Transplantation. 61
30896679 2019
16
BK Polyomavirus-specific T cell immune responses in kidney transplant recipients diagnosed with BK Polyomavirus-associated nephropathy. 61
31744480 2019
17
Multiplex analysis of Human Polyomavirus diversity in kidney transplant recipients with BK virus replication. 61
31505316 2019
18
Viral load and duration of BK polyomavirus viraemia determine renal graft fibrosis progression: histologic evaluation of late protocol biopsies. 61
31071208 2019
19
Cytomegalovirus prevention strategies and the risk of BK polyomavirus viremia and nephropathy. 61
31220412 2019
20
Kidney graft failure induced by BKPyV replication despite a strong reduction of the immunosuppressive therapy. 61
30866070 2019
21
Significant Suppression of Staphylococcus aureus Colonization on Intramedullary Ti6Al4V Implants Surface-Grafted with Vancomycin-Bearing Polymer Brushes. 61
31313901 2019
22
Poly(4-vinylaniline)/Polyaniline Bilayer-Functionalized Bacterial Cellulose for Flexible Electrochemical Biosensors. 61
31318565 2019
23
Epidemiology of and Risk Factors for BK Polyomavirus Replication and Nephropathy in Pediatric Renal Transplant Recipients: An International CERTAIN Registry Study. 61
30130322 2019
24
Expression of novel proteins by polyomaviruses and recent advances in the structural and functional features of agnoprotein of JC virus, BK virus, and simian virus 40. 61
30390301 2019
25
Predictive Value of the Combination of Peripheral Blood Lymphocyte Count and Urinary Cytology in BK Polyomavirus-associated Nephropathy. 61
31056251 2019
26
Variable sources of Bk virus in renal allograft recipients. 61
30680753 2019
27
Persistent polyomavirus-associated nephropathy in a patient with GvHD and treatment with the JAK1/2 inhibitor ruxolitinib. 61
30349038 2019
28
Glomerular Parietal Epithelial Cells Infection Is Associated With Poor Graft Outcome in Kidney Transplant Recipients With BK Polyomavirus-Associated Nephropathy. 61
30649366 2019
29
Clinical utility of leflunomide for BK polyomavirus associated nephropathy in kidney transplant recipients: A multicenter retrospective study. 61
30730102 2019
30
Incidence, risk factors, and outcome of BK polyomavirus infection after kidney transplantation. 61
30746369 2019
31
Poly(4-vinylaniline)/polyaniline bilayer functionalized bacterial cellulose membranes as bioelectronics interfaces. 61
30366531 2019
32
Kidney transplant recipients with polycystic kidney disease have a lower risk of post-transplant BK infection than those with end-stage renal disease due to other causes. 61
30102820 2018
33
Impact of immune suppressive agents on the BK-Polyomavirus non coding control region. 61
30268912 2018
34
Differential profiles of adverse events associated with mycophenolate mofetil between adult and pediatric renal transplant patients. 61
30060680 2018
35
Nucleic Acid Tests for BK Polyomavirus Is Critical in Renal Transplant Recipients. 61
30316383 2018
36
Granulomatous inflammation in BK polyomavirus-associated nephropathy. 61
29863293 2018
37
Elimination of BK viremia in renal transplant recipients by optimization of immunosuppressive medications without precipitating acute rejection. 61
30381503 2018
38
BK Polyomavirus Immune Response With Stress on BK-Specific T Cells. 61
29766776 2018
39
The Structure of an Infectious Human Polyomavirus and Its Interactions with Cellular Receptors. 61
29706532 2018
40
BK polyomavirus microRNA expression and sequence variation in polyomavirus-associated nephropathy. 61
29518695 2018
41
Aryl hydrocarbon receptor expression by macrophages and lymphocytes within infiltrates in BK polyomavirus associated nephropathy. 61
29305091 2018
42
Severe BK polyomavirus-induced hemorrhagic cystitis in a kidney transplant recipient with the absence of renal allograft involvement. 61
29143415 2018
43
Association of BK Virus Infection with CXCL11 Gene Expression and Protein Levels in Kidney Transplant Patients. 61
27759557 2018
44
Absence of JC polyomavirus (JCPyV) viremia in early post-transplant JCPyV nephropathy: A case report. 61
28805990 2017
45
Kidney allograft failure in the steroid-free immunosuppression era: A matched case-control study. 61
28921709 2017
46
Clinical-Scale Rapid Autologous BK Virus-Specific T Cell Line Generation From Kidney Transplant Recipients With Active Viremia for Adoptive Immunotherapy. 61
28230645 2017
47
Simultaneous pancreas/kidney transplant recipients are predisposed to tissue-invasive cytomegalovirus disease and concomitant infectious complications. 61
28665480 2017
48
Identification of Rab18 as an Essential Host Factor for BK Polyomavirus Infection Using a Whole-Genome RNA Interference Screen. 61
28815213 2017
49
Stabilization of renal function after the first year of follow-up in kidney transplant recipients treated for significant BK polyomavirus infection or BK polyomavirus-associated nephropathy. 61
28207975 2017
50
Ultrasound findings of BK polyomavirus-associated nephropathy in renal transplant patients. 61
27342655 2017

Variations for Polyomavirus-Associated Nephropathy

Expression for Polyomavirus-Associated Nephropathy

Search GEO for disease gene expression data for Polyomavirus-Associated Nephropathy.

Pathways for Polyomavirus-Associated Nephropathy

Pathways related to Polyomavirus-Associated Nephropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.97 MAPT HSD17B10 GAPDH

GO Terms for Polyomavirus-Associated Nephropathy

Cellular components related to Polyomavirus-Associated Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GAIT complex GO:0097452 8.62 GAPDH EPRS1

Biological processes related to Polyomavirus-Associated Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of translation GO:0006417 8.8 GAPDH EPRS1 CTIF

Molecular functions related to Polyomavirus-Associated Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA binding GO:0003723 9.17 PPP1R8 NOSIP MAPT JMJD6 HSD17B10 EPRS1

Sources for Polyomavirus-Associated Nephropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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