PVAN
MCID: PLY179
MIFTS: 25

Polyomavirus-Associated Nephropathy (PVAN)

Categories: Infectious diseases, Nephrological diseases

Aliases & Classifications for Polyomavirus-Associated Nephropathy

MalaCards integrated aliases for Polyomavirus-Associated Nephropathy:

Name: Polyomavirus-Associated Nephropathy 12 15
Polyomavirus Associated Nephropathy 12
Pvan 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0040086
SNOMED-CT 67 713886006
UMLS 71 C1697878

Summaries for Polyomavirus-Associated Nephropathy

Disease Ontology : 12 A viral infectious disease has material basis in BK polyomavirus.

MalaCards based summary : Polyomavirus-Associated Nephropathy, also known as polyomavirus associated nephropathy, is related to interstitial nephritis and hantavirus hemorrhagic fever with renal syndrome. An important gene associated with Polyomavirus-Associated Nephropathy is NDUFB4 (NADH:Ubiquinone Oxidoreductase Subunit B4). Affiliated tissues include kidney, pancreas and heart, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Polyomavirus-Associated Nephropathy

Diseases related to Polyomavirus-Associated Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 interstitial nephritis 10.2
2 hantavirus hemorrhagic fever with renal syndrome 10.1 NDUFB4 LINC01194
3 bk-virus nephropathy 10.1
4 hemorrhagic cystitis 10.1 LINC01194 EPRS1
5 kaposi sarcoma 10.0
6 type 1 diabetes mellitus 10.0
7 obstructive nephropathy 10.0
8 nephrosclerosis 10.0
9 transitional cell carcinoma 10.0
10 skin squamous cell carcinoma 10.0
11 arteriolosclerosis 10.0
12 end stage renal disease 10.0
13 48,xyyy 10.0
14 thrombotic microangiopathy 10.0
15 mitral valve insufficiency 9.9 NPPA MYH6

Graphical network of the top 20 diseases related to Polyomavirus-Associated Nephropathy:



Diseases related to Polyomavirus-Associated Nephropathy

Symptoms & Phenotypes for Polyomavirus-Associated Nephropathy

GenomeRNAi Phenotypes related to Polyomavirus-Associated Nephropathy according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-115 9.53 NDUFB4
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.53 PPP1R8
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.53 NFATC3
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-146 9.53 PPP1R8
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-158 9.53 PPP1R8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-170 9.53 NFATC3
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.53 NDUFB4
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-189 9.53 NDUFB4
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.53 NFATC3
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-198 9.53 NDUFB4
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.53 NDUFB4
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-31 9.53 PPP1R8
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-54 9.53 PPP1R8
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.53 NDUFB4
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-78 9.53 PPP1R8
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-96 9.53 PPP1R8

Drugs & Therapeutics for Polyomavirus-Associated Nephropathy

Search Clinical Trials , NIH Clinical Center for Polyomavirus-Associated Nephropathy

Genetic Tests for Polyomavirus-Associated Nephropathy

Anatomical Context for Polyomavirus-Associated Nephropathy

MalaCards organs/tissues related to Polyomavirus-Associated Nephropathy:

40
Kidney, Pancreas, Heart, T Cells, Bone Marrow, Bone, Brain

Publications for Polyomavirus-Associated Nephropathy

Articles related to Polyomavirus-Associated Nephropathy:

(show top 50) (show all 270)
# Title Authors PMID Year
1
Viruria of Human BK Virus and John Cunningham Virus among Renal Transplant Recipients and Healthy Control in Southeast of Caspian Sea. 61
33596566 2021
2
Non-permissive human conventional CD1c+ dendritic cells enable trans-infection of human primary renal tubular epithelial cells and protect BK polyomavirus from neutralization. 61
33592065 2021
3
Significance of revised criteria for chronic active T cell-mediated rejection in the 2017 Banff classification: Surveillance by 1-year protocol biopsies for kidney transplantation. 61
32484280 2021
4
Upregulation of HLA-F expression by BK polyomavirus infection induces immune recognition by KIR3DS1-positive natural killer cells. 61
33359499 2020
5
An application of the 2018 Banff Classification for BK polyomavirus-associated nephropathy in renal transplantation. 61
33377580 2020
6
Control of Archetype BK Polyomavirus MicroRNA Expression. 61
33115878 2020
7
Functional immune monitoring of BK Virus and donor-specific T-cell effector immune responses to guide treatment decision-making after kidney transplantation; an illustrative case report and literature review. 61
33070461 2020
8
Leflunomide in the treatment of BK polyomavirus associated nephropathy in kidney transplanted patients - A systematic review. 61
32611496 2020
9
Nephrotoxicity of calcineurin inhibitors as a risk factor for BK polyomavirus replication after kidney transplantation. 61
32940913 2020
10
Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015-19. 61
32962215 2020
11
Impedance mapping with constant contact force on 3D electroanatomic map to characterize tissues at pulmonary veno-atrial junction. 61
32749567 2020
12
Pathological characteristics of BK polyomavirus-associated nephropathy with glomerular involvement. 61
32953723 2020
13
BKTyper: Free Online Tool for Polyoma BK Virus VP1 and NCCR Typing. 61
32751885 2020
14
Possibility of BKV-Associated Nephropathy in Hospitalized Burn Patients. 61
31867602 2020
15
Longitudinal assessment of the CXCL10 blood and urine concentration in kidney transplant recipients with BK polyomavirus replication-a retrospective study. 61
31981424 2020
16
BK Virus RNA in Renal Allograft Biopsies. 61
32352851 2020
17
Immunosuppression, BK polyomavirus infections, and BK polyomavirus-specific T cells after pediatric kidney transplantation. 61
31858227 2020
18
Low-dose cidofovir and conversion to mTOR-based immunosuppression in polyomavirus-associated nephropathy. 61
31797495 2020
19
Mitral chordae tendineae force profile characterization using a posterior ventricular anchoring neochordal repair model for mitral regurgitation in a three-dimensional-printed ex vivo left heart simulator. 61
31638697 2020
20
Non-invasive urinary sediment double-immunostaining predicts BK polyomavirus associated-nephropathy in kidney transplant recipients. 61
32309382 2020
21
BK Polyomavirus-associated nephropathy managed by screening policy in a real-life setting. 61
31724282 2020
22
Use of intravenous immunoglobulin in a highly sensitized pediatric renal transplant recipient with severe BK DNAemia and rising DSA. 61
31657100 2020
23
Urine Donor-Derived Cell-Free DNA Helps Discriminate BK Polyomavirus-Associated Nephropathy in Kidney Transplant Recipients With BK Polyomavirus Infection. 61
32973745 2020
24
Next-generation sequencing shows marked rearrangements of BK polyomavirus that favor but are not required for polyomavirus-associated nephropathy. 61
31783265 2020
25
Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys. 61
31971979 2020
26
Comparison of Immunohistochemical Staining for Large T Antigen and Capsid Protein VP1 in BK Polyomavirus-Associated Nephropathy. 61
33221810 2020
27
Detection of Proximal Tubule Involvement by BK Polyomavirus in Kidney Transplant Recipients With Urinary Sediment Double-Immunostaining. 61
33072129 2020
28
Clinical Efficacy of Intravenous Immunoglobulin for BK Polyomavirus-Associated Nephropathy After Living Kidney Transplantation. 61
33116544 2020
29
Pathogenicity of BK virus on the urinary system. 61
32395331 2020
30
Early fulminant BK polyomavirus-associated nephropathy in two kidney transplant patients with low neutralizing antibody titers receiving allografts from the same donor. 61
31924245 2020
31
A Multicenter Application of the 2018 Banff Classification for BK Polyomavirus-associated Nephropathy in Renal Transplantation. 61
30896679 2019
32
BK Polyomavirus-specific T cell immune responses in kidney transplant recipients diagnosed with BK Polyomavirus-associated nephropathy. 61
31744480 2019
33
Multiplex analysis of Human Polyomavirus diversity in kidney transplant recipients with BK virus replication. 61
31505316 2019
34
Viral load and duration of BK polyomavirus viraemia determine renal graft fibrosis progression: histologic evaluation of late protocol biopsies. 61
31071208 2019
35
Kidney graft failure induced by BKPyV replication despite a strong reduction of the immunosuppressive therapy. 61
30866070 2019
36
Cytomegalovirus prevention strategies and the risk of BK polyomavirus viremia and nephropathy. 61
31220412 2019
37
Significant Suppression of Staphylococcus aureus Colonization on Intramedullary Ti6Al4V Implants Surface-Grafted with Vancomycin-Bearing Polymer Brushes. 61
31313901 2019
38
Poly(4-vinylaniline)/Polyaniline Bilayer-Functionalized Bacterial Cellulose for Flexible Electrochemical Biosensors. 61
31318565 2019
39
Epidemiology of and Risk Factors for BK Polyomavirus Replication and Nephropathy in Pediatric Renal Transplant Recipients: An International CERTAIN Registry Study. 61
30130322 2019
40
Variable sources of Bk virus in renal allograft recipients. 61
30680753 2019
41
Expression of novel proteins by polyomaviruses and recent advances in the structural and functional features of agnoprotein of JC virus, BK virus, and simian virus 40. 61
30390301 2019
42
Predictive Value of the Combination of Peripheral Blood Lymphocyte Count and Urinary Cytology in BK Polyomavirus-associated Nephropathy. 61
31056251 2019
43
Carbon Nanotube-Reinforced Poly(4-vinylaniline)/Polyaniline Bilayer-Grafted Bacterial Cellulose for Bioelectronic Applications. 61
33405718 2019
44
Glomerular Parietal Epithelial Cells Infection Is Associated With Poor Graft Outcome in Kidney Transplant Recipients With BK Polyomavirus-Associated Nephropathy. 61
30649366 2019
45
Persistent polyomavirus-associated nephropathy in a patient with GvHD and treatment with the JAK1/2 inhibitor ruxolitinib. 61
30349038 2019
46
Clinical utility of leflunomide for BK polyomavirus associated nephropathy in kidney transplant recipients: A multicenter retrospective study. 61
30730102 2019
47
Incidence, risk factors, and outcome of BK polyomavirus infection after kidney transplantation. 61
30746369 2019
48
Poly(4-vinylaniline)/polyaniline bilayer functionalized bacterial cellulose membranes as bioelectronics interfaces. 61
30366531 2019
49
Kidney transplant recipients with polycystic kidney disease have a lower risk of post-transplant BK infection than those with end-stage renal disease due to other causes. 61
30102820 2018
50
Differential profiles of adverse events associated with mycophenolate mofetil between adult and pediatric renal transplant patients. 61
30060680 2018

Variations for Polyomavirus-Associated Nephropathy

Expression for Polyomavirus-Associated Nephropathy

Search GEO for disease gene expression data for Polyomavirus-Associated Nephropathy.

Pathways for Polyomavirus-Associated Nephropathy

GO Terms for Polyomavirus-Associated Nephropathy

Cellular components related to Polyomavirus-Associated Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GAIT complex GO:0097452 8.62 GAPDH EPRS1

Biological processes related to Polyomavirus-Associated Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of translation GO:0006417 9.13 GAPDH EPRS1 CTIF
2 cardiac muscle hypertrophy in response to stress GO:0014898 8.62 NPPA MYH6

Sources for Polyomavirus-Associated Nephropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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