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PVAN
MCID: PLY179
MIFTS: 22

Polyomavirus-Associated Nephropathy (PVAN)

Categories: Infectious diseases, Nephrological diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Polyomavirus-Associated Nephropathy

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MalaCards integrated aliases for Polyomavirus-Associated Nephropathy:

Name: Polyomavirus-Associated Nephropathy 12 15
Polyomavirus Associated Nephropathy 12
Pvan 12

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0040086
UMLS 73 C1697878
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Summaries for Polyomavirus-Associated Nephropathy

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Disease Ontology : 12 A viral infectious disease has material basis in BK polyomavirus.

MalaCards based summary : Polyomavirus-Associated Nephropathy, also known as polyomavirus associated nephropathy, is related to kidney disease and hematopoietic stem cell transplantation. An important gene associated with Polyomavirus-Associated Nephropathy is STX18 (Syntaxin 18), and among its related pathways/superpathways are Hepatitis C and Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics. The drugs Ergocalciferol and Vitamin D3 have been mentioned in the context of this disorder. Affiliated tissues include kidney, pancreas and testes.

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Related Diseases for Polyomavirus-Associated Nephropathy

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Diseases related to Polyomavirus-Associated Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 kidney disease 10.2
2 hematopoietic stem cell transplantation 10.0
3 viral infectious disease 10.0

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Symptoms & Phenotypes for Polyomavirus-Associated Nephropathy

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Drugs & Therapeutics for Polyomavirus-Associated Nephropathy

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Drugs for Polyomavirus-Associated Nephropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
2
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
3
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
4 Micronutrients Phase 4
5 Epoetin alfa Phase 4 113427-24-0
6 Trace Elements Phase 4
7 Ergocalciferols Phase 4
8 Bone Density Conservation Agents Phase 4
9 Vitamin D2 Phase 4
10 Calciferol Phase 4
11 Hematinics Phase 4
12 Vitamins Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Correcting Anemia and Native Vitamin D Supplementation in Kidney Transplant Recipients Enrolling by invitation NCT01817699 Phase 4

Search NIH Clinical Center for Polyomavirus-Associated Nephropathy

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Genetic Tests for Polyomavirus-Associated Nephropathy

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Anatomical Context for Polyomavirus-Associated Nephropathy

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MalaCards organs/tissues related to Polyomavirus-Associated Nephropathy:

41
Kidney, Pancreas, Testes, Myeloid
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Publications for Polyomavirus-Associated Nephropathy

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Articles related to Polyomavirus-Associated Nephropathy:

(show top 50) (show all 58)
# Title Authors Year
1
Aryl hydrocarbon receptor expression by macrophages and lymphocytes within infiltrates in BK polyomavirus associated nephropathy. ( 29305091 )
2018
2
BK polyomavirus microRNA expression and sequence variation in polyomavirus-associated nephropathy. ( 29518695 )
2018
3
Granulomatous inflammation in BK polyomavirus-associated nephropathy. ( 29863293 )
2018
4
Persistent polyomavirus-associated nephropathy in a patient with GvHD and treatment with the JAK1/2 inhibitor ruxolitinib. ( 30349038 )
2018
5
Ultrasound findings of BK polyomavirus-associated nephropathy in renal transplant patients. ( 27342655 )
2017
6
Stabilization of renal function after the first year of follow-up in kidney transplant recipients treated for significant BK polyomavirus infection or BK polyomavirus-associated nephropathy. ( 28207975 )
2017
7
A delicate balance between rejection and BK polyomavirus associated nephropathy; A retrospective cohort study in renal transplant recipients. ( 28609473 )
2017
8
BK virus infection activates the TNFα/TNF receptor system in Polyomavirus-associated nephropathy. ( 26446017 )
2016
9
Intragraft Blood Dendritic Cell Antigen-1-Positive Myeloid Dendritic Cells Increase during BK Polyomavirus-Associated Nephropathy. ( 26701980 )
2016
10
Simultaneous pancreas/kidney transplant recipients present with late-onset BK polyomavirus-associated nephropathy. ( 26758790 )
2016
11
Concurrent cytomegalovirus glomerulitis and BK polyomavirus-associated nephropathy in a kidney allograft biopsy. ( 26782090 )
2016
12
Predominant Tubular Interleukin-18 Expression in Polyomavirus-Associated Nephropathy. ( 26863474 )
2016
13
Intragraft Antiviral-Specific Gene Expression as a Distinctive Transcriptional Signature for Studies in Polyomavirus-Associated Nephropathy. ( 27140517 )
2016
14
Polyomavirus-associated nephropathy in renal and simultaneous pancreas-kidney transplant recipients: report of three cases. ( 25579723 )
2015
15
Brincidofovir for polyomavirus-associated nephropathy after allogeneic hematopoietic stem cell transplantation. ( 25600489 )
2015
16
Falsely decreased ionized calcium levels in kidney transplant recipients with polyomavirus-associated nephropathy treated with leflunomide. ( 25711674 )
2015
17
Early identification of renal transplant recipients with high risk of polyomavirus-associated nephropathy. ( 25749892 )
2015
18
Impact of HMG-CoA reductase inhibitors on the incidence of polyomavirus-associated nephropathy in renal transplant recipients with human BK polyomavirus viremia. ( 25989423 )
2015
19
Factors Influencing Graft Outcomes Following Diagnosis of Polyomavirus -Associated Nephropathy after Renal Transplantation. ( 26544696 )
2015
20
Treatment of Polyomavirus-Associated Nephropathy With the Association of Sirolimus and Leflunomide. ( 26643679 )
2015
21
Pathology of resolving polyomavirus-associated nephropathy. ( 23721552 )
2013
22
Adaptive immunity rather than viral cytopathology mediates polyomavirus-associated nephropathy in mice. ( 22420885 )
2012
23
Management of polyomavirus-associated nephropathy in renal transplant recipients. ( 22508181 )
2012
24
Analytical and clinical performance characteristics of the Simplexa BK virus quantitative PCR assay for the diagnosis of polyomavirus-associated nephropathy in renal transplant recipients using plasma and urine specimens. ( 22975084 )
2012
25
Adaptive immunity rather than viral cytopathology mediates polyomavirus-associated nephropathy in mice. ( 22994873 )
2012
26
Polyomavirus-associated nephropathy. ( 24175200 )
2012
27
Polyomavirus associated nephropathy presenting five years after kidney transplantation. ( 21999857 )
2011
28
Polyomavirus-associated nephropathy: a comparison of 2 different strategies for immunosuppression reduction. ( 21857366 )
2011
29
High incidence of malignancy in polyomavirus-associated nephropathy in renal transplant recipients. ( 20430180 )
2010
30
Polyomavirus associated nephropathy after kidney and pancreas transplantation: case report. ( 20698140 )
2010
31
Reducing immunosuppression preserves allograft function in presumptive and definitive polyomavirus-associated nephropathy. ( 21114642 )
2010
32
Evaluation of a preemptive strategy for BK polyomavirus-associated nephropathy based on prospective monitoring of BK viremia: a kidney transplantation center experience. ( 21168633 )
2010
33
The effect of low-dose cidofovir on the long-term outcome of polyomavirus-associated nephropathy in renal transplant recipients. ( 19059933 )
2009
34
Detection, distribution, and pathologic significance of BK virus strains isolated from patients with kidney transplants, with and without polyomavirus-associated nephropathy. ( 19415951 )
2009
35
Diagnostic accuracy of blood qualitative nucleic acid testing for polyomavirus-associated nephropathy in kidney recipients. ( 19444968 )
2009
36
Screening for polyomavirus associated nephropathy in renal transplantation with blood viral load measurement. ( 19559645 )
2009
37
Polyomavirus-associated nephropathy: critical issues in virological monitoring. ( 19845105 )
2009
38
A case of polyomavirus-associated nephropathy presenting late after transplantation. ( 18334968 )
2008
39
Antiviral therapy for polyomavirus-associated nephropathy after renal transplantation. ( 18658193 )
2008
40
Low-dose cidofovir for the treatment of polyomavirus-associated nephropathy: two case reports and review of the literature. ( 19195325 )
2008
41
Polyomavirus-associated nephropathy risk in kidney transplants: the influence of recipient age and donor gender. ( 17410099 )
2007
42
Polyomavirus polymerase chain reaction as a surrogate marker of polyomavirus-associated nephropathy. ( 17700158 )
2007
43
BK virus regulatory region sequence deletions in a case of human polyomavirus associated nephropathy (PVAN) after kidney transplantation. ( 16202649 )
2006
44
Retransplantation after polyomavirus-associated nephropathy: just do it? ( 16433749 )
2006
45
A mouse model for polyomavirus-associated nephropathy of kidney transplants. ( 16611327 )
2006
46
Kidney transplant function and histological clearance of virus following diagnosis of polyomavirus-associated nephropathy (PVAN). ( 16611340 )
2006
47
Polyomavirus-associated nephropathy in renal transplantation: critical issues of screening and management. ( 16626034 )
2006
48
Polyomavirus-associated nephropathy: updates on a persisting challenge. ( 16734627 )
2006
49
Polyomavirus-associated nephropathy: update in diagnosis. ( 16734629 )
2006
50
Polyomavirus-associated nephropathy: update of clinical management in kidney transplant patients. ( 16734630 )
2006
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Variations for Polyomavirus-Associated Nephropathy

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Expression for Polyomavirus-Associated Nephropathy

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Search GEO for disease gene expression data for Polyomavirus-Associated Nephropathy.
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Pathways for Polyomavirus-Associated Nephropathy

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Pathways related to Polyomavirus-Associated Nephropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Hepatitis C 37
11.07 DDX58 IRF9
2
Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics 61
Show member pathways
 9.98 DDX58 IRF9
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GO Terms for Polyomavirus-Associated Nephropathy

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Sources for Polyomavirus-Associated Nephropathy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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