MCID: PLY100
MIFTS: 41

Polyploidy

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Polyploidy

MalaCards integrated aliases for Polyploidy:

Name: Polyploidy 59

Classifications:



External Ids:

MESH via Orphanet 45 D011123
ICD10 via Orphanet 34 Q92.7
UMLS via Orphanet 73 C0032578
Orphanet 59 ORPHA96321

Summaries for Polyploidy

MalaCards based summary : Polyploidy is related to tetraploidy and triploidy. An important gene associated with Polyploidy is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Cell Cycle, Mitotic and Regulation of TP53 Activity. Affiliated tissues include liver, smooth muscle and breast, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Wikipedia : 75 Polyploidy is the state of a cell or organism having more than two paired (homologous) sets of... more...

Related Diseases for Polyploidy

Diseases related to Polyploidy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)
# Related Disease Score Top Affiliating Genes
1 tetraploidy 32.9 TP73 AURKB
2 triploidy 12.0
3 hypomelanosis of ito 11.2
4 macrozoospermia 11.2
5 parameningeal embryonal rhabdomyosarcoma 10.2 TP53 ALK
6 papillomatosis, confluent and reticulated 10.2
7 lymphoma 10.2
8 48,xyyy 10.2
9 lung papillary adenocarcinoma 10.2 TP53 ALK
10 hair whorl 10.2
11 autoimmune lymphoproliferative syndrome 10.2
12 leukemia 10.2
13 b-cell lymphoma 10.2
14 pleomorphic carcinoma 10.1 TP53 ALK
15 nondisjunction 10.1
16 polykaryocytosis inducer 10.1
17 retinoblastoma 10.1
18 leukemia, acute myeloid 10.1
19 acute promyelocytic leukemia 10.1
20 myelodysplastic syndrome 10.1
21 diffuse large b-cell lymphoma 10.1
22 melanoma 10.1
23 hermaphroditism 10.1
24 familial retinoblastoma 10.1
25 infertility 10.1
26 47,xyy 10.1
27 gigantism 10.1
28 retinal cancer 10.0 TP53 CDK1
29 spermatogenic failure 5 10.0
30 myelofibrosis 10.0
31 osteogenic sarcoma 10.0
32 papilloma of choroid plexus 10.0
33 barrett esophagus 10.0
34 pachyonychia congenita 3 10.0
35 deficiency anemia 10.0
36 polycystic kidney disease 10.0
37 goiter 10.0
38 squamous cell papilloma 10.0
39 papilloma 10.0
40 glioblastoma multiforme 10.0
41 atypical choroid plexus papilloma 10.0
42 liver disease 10.0
43 hyperglycemia 10.0
44 kidney disease 10.0
45 hemolytic anemia 10.0
46 adenoma 10.0
47 myeloid leukemia 10.0
48 autosomal dominant polycystic kidney disease 10.0
49 chromosomal triplication 10.0
50 familial hypertension 10.0

Graphical network of the top 20 diseases related to Polyploidy:



Diseases related to Polyploidy

Symptoms & Phenotypes for Polyploidy

GenomeRNAi Phenotypes related to Polyploidy according to GeneCards Suite gene sharing:

26 (show all 31)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 10.82 BUB1 CDK1 PLK1
2 Decreased substrate adherent cell growth GR00193-A-2 10.82 BUB1 PLK1 ALK AURKB
3 Decreased substrate adherent cell growth GR00193-A-3 10.82 BUB1 CDK1 PLK1
4 Decreased substrate adherent cell growth GR00193-A-4 10.82 BUB1 PLK1 AURKB AURKC
5 Decreased viability GR00055-A-2 10.63 PLK1 AURKC
6 Decreased viability GR00173-A 10.63 AURKB PLK1
7 Decreased viability GR00221-A-1 10.63 AURKB
8 Decreased viability GR00221-A-2 10.63 AURKB PLK1
9 Decreased viability GR00221-A-3 10.63 AURKC
10 Decreased viability GR00221-A-4 10.63 AURKB AURKC
11 Decreased viability GR00231-A 10.63 PLK1
12 Decreased viability GR00240-S-1 10.63 PLK1
13 Decreased viability GR00301-A 10.63 PLK1 AURKC BUB1 CDK1
14 Decreased viability GR00342-S-1 10.63 AURKC
15 Decreased viability GR00381-A-1 10.63 AURKC
16 Decreased viability GR00402-S-2 10.63 AURKB PLK1 AURKC BUB1 CDK1
17 Decreased cell migration GR00055-A-1 9.84 ALK AURKC CDK1 PLK1
18 Condensed cis-Golgi GR00365-A 9.73 AURKB BUB1 CDK1
19 Effect on mitosis GR00257-A-2 9.73 AURKB AURKC BUB1 PLK1
20 Decreased CDKN1A mRNA expression GR00389-S-1 9.72 TP53
21 Decreased CDKN1A mRNA expression GR00389-S-2 9.72 PLK1 TP53
22 Decreased cella89culturea89derived Hepatitis C virus (HCVcc; Luca89Jc1) infection GR00234-A-2 9.7 AURKB CDK1 PLK1
23 Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection GR00234-A-1 9.69 AURKB CDK1 PLK1
24 Increased cell number in S GR00096-A 9.67 AURKB BUB1 CDK1 PLK1
25 Decreased TP53 mRNA expression GR00389-S-5 9.48 PLK1 TP53
26 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.46 CDK1 PLK1 TP53 TP73
27 Increased BBC3 mRNA expression GR00389-S-4 9.4 PLK1 TP53
28 Increased proliferation GR00094-A 9.32 BUB1 TP53
29 Increased TP53 mRNA expression GR00389-S-6 9.26 PLK1 TP53
30 Increased viability with TRAIL GR00154-A 8.96 BUB1 PLK1
31 Misorientated spindle GR00256-A 8.8 ALK AURKC PLK1

MGI Mouse Phenotypes related to Polyploidy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.7 ALK AURKB BUB1 CDK1 PLK1 TP53
2 embryo MP:0005380 9.65 AURKB CDK1 PLK1 TP53 TP73
3 neoplasm MP:0002006 9.5 ALK AURKB BUB1 CDK1 PLK1 TP53
4 reproductive system MP:0005389 9.17 ALK AURKB AURKC BUB1 CDK1 TP53

Drugs & Therapeutics for Polyploidy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparaison de la Chromo Endoscopie Virtuelle FICE (Fujinon Intelligent Chromoendoscopy) Avec la Coloscopie Conventionnelle Dans la détection de la Dysplasie Chez Patients Porteurs de Recto Colite ulcéro hémorragique (RCH). Unknown status NCT00816491
2 Ultrasensitive Chromosomal Aneuploidy Detection (UCAD) in Urine Exfoliated Cells for Diagnosis of Urothelial Carcinoma in in Urine Exfoliated Cells Recruiting NCT03998371
3 Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics Not yet recruiting NCT03325517

Search NIH Clinical Center for Polyploidy

Genetic Tests for Polyploidy

Anatomical Context for Polyploidy

MalaCards organs/tissues related to Polyploidy:

41
Liver, Smooth Muscle, Breast, Lung, Testes, Bone, Heart

Publications for Polyploidy

Articles related to Polyploidy:

(show top 50) (show all 3709)
# Title Authors PMID Year
1
'At the crossroads towards polyploidy': genomic divergence and extent of homoploid hybridization are drivers for the formation of the ox-eye daisy polyploid complex (Leucanthemum, Compositae-Anthemideae). 38
30851196 2019
2
Identification and evaluation of novel drug combinations of Aurora kinase inhibitor CCT137690 for enhanced efficacy in oral cancer cells. 38
31318643 2019
3
Traction forces at the cytokinetic ring regulate cell division and polyploidy in the migrating zebrafish epicardium. 38
31160803 2019
4
A new biological species in the Mercurialis annua polyploid complex: functional divergence in inflorescence morphology and hybrid sterility. 38
31098610 2019
5
Wound-induced polyploidization is driven by Myc and supports tissue repair in the presence of DNA damage. 38
31315896 2019
6
Evaluation of two aneuploidy screening tests for chorionic villus samples: Multiplex ligation-dependent probe amplification and fluorescence in situ hybridization. 38
31319160 2019
7
Characterization and expression profiles of miRNAs in the triploid hybrids of Brassica napus and Brassica rapa. 38
31412776 2019
8
Heat Stress-Induced Multiple Multipolar Divisions of Human Cancer Cells. 38
31412680 2019
9
Reconciling event-labeled gene trees with MUL-trees and species networks. 38
31410552 2019
10
Population genomics of an exceptional hybridogenetic system of Pelophylax water frogs. 38
31382876 2019
11
Genome-wide analysis of alternative splicing divergences between Brassica hexaploid and its parents. 38
31139927 2019
12
A little bit of sex prevents mutation accumulation even in apomictic polyploid plants. 38
31412772 2019
13
Resistance in marine cyanobacteria differs against specialist and generalist cyanophages. 38
31383764 2019
14
Polyploidy promotes species diversification of Allium through ecological shifts. 38
31394010 2019
15
[PROVISIONAL] Chromosomal variability in Brazilian species of Anthurium Schott (Araceae): heterochromatin, polyploidy, and B chromosomes. 38
31429859 2019
16
Cytological and transcriptome analysis reveal that interaction at Sb pollen sterility locus cause down-regulation of important meiosis-related genes associated with high pollen sterility in autotetraploid rice hybrids. 38
31132695 2019
17
Stem cell-based small-diameter vascular grafts in dynamic culture. 38
31379220 2019
18
Conservation of the Threatened Species, Pulsatilla vulgaris Mill. (Pasqueflower), is Aided by Reproductive System and Polyploidy. 38
31102445 2019
19
Performance of gene expression analyses using de novo assembled transcripts in polyploid species. 38
31400193 2019
20
The avocado genome informs deep angiosperm phylogeny, highlights introgressive hybridization, and reveals pathogen-influenced gene space adaptation. 38
31387975 2019
21
Biotechnological interventions on the genus Rauvolfia: recent trends and imminent prospects. 38
31363825 2019
22
Proteomic and metabolomic insights into the functions of the male reproductive system in fishes. 38
31029849 2019
23
Impacts of soil nitrogen and phosphorus levels on cytotype performance of the circumboreal herb Chamerion angustifolium: implications for polyploid establishment. 38
31283844 2019
24
Allopolyploid origin in Rubus (Rosaceae) inferred from nuclear granule-bound starch synthase I (GBSSI) sequences. 38
31291892 2019
25
Threonine Tyrosine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy. 38
31358662 2019
26
How does genome size affect the evolution of pollen tube growth rate, a haploid performance trait? 38
31294836 2019
27
Parallelism and convergence in post-domestication adaptation in cereal grasses. 38
31154975 2019
28
iTRAQ-based proteome profiling of hyposaline responses in zygotes of the Pacific oyster Crassostrea gigas. 38
30771561 2019
29
Irrigation affects characteristics of narrow-leaved lupin (Lupinus angustifolius L.) seeds. 38
30684036 2019
30
Genome-wide alternative splicing landscapes modulated by biotrophic sugarcane smut pathogen. 38
31222001 2019
31
Hepatitis B virus X protein enhances the development of liver fibrosis and the expression of genes associated with epithelial-mesenchymal transitions and tumor progenitor cells. 38
31175830 2019
32
ChIP-cloning analysis uncovers centromere-specific retrotransposons in Brassica nigra and reveals their rapid diversification in Brassica allotetraploids. 38
30993455 2019
33
Role of ploidy in colonization of alpine habitats in natural populations of Arabidopsis arenosa. 38
31185073 2019
34
Comparative karyotype analysis among cytotypes of Cynodon dactylon (L.) Pers. (Poaceae). 38
31240527 2019
35
Hybrid sequencing reveals insight into heat sensing and signaling of bread wheat. 38
30891832 2019
36
Comparative genomics reveals origin of MIR159A-MIR159B paralogy, and complexities of PTGS interaction between miR159 and target GA-MYBs in Brassicaceae. 38
30840147 2019
37
Mass spectrometric characterization of the zein protein composition in maize flour extracts upon protein separation by SDS-PAGE and 2D gel electrophoresis. 38
31169923 2019
38
Evolutionary history of the Pasque-flowers (Pulsatilla, Ranunculaceae): Molecular phylogenetics, systematics and rDNA evolution. 38
30831271 2019
39
Detecting novel mutations and combined Klinefelter syndrome in Usher syndrome cases. 38
31035849 2019
40
Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling. 38
30916493 2019
41
Polyploidy in halophilic archaea: regulation, evolutionary advantages, and gene conversion. 38
31189733 2019
42
The origins and functions of hepatic polyploidy. 38
31096847 2019
43
Polyploid Hepatocytes Facilitate Adaptation and Regeneration to Chronic Liver Injury. 38
30928253 2019
44
[Genetic testing of chorionic villi from abortuses during early pregnancy]. 38
31055802 2019
45
[Hepatic polyploidy: Dr Jekyll or Mr Hyde]. 38
31274081 2019
46
Role for polo-like kinase 4 in mediation of cytokinesis. 38
31097597 2019
47
Development and characterization of microsatellite markers for Antennaria corymbosa (Asteraceae) and close relatives. 38
31236315 2019
48
Next-generation transcriptome assembly and analysis: Impact of ploidy. 38
31176772 2019
49
Studies on Colchicine Induced Chromosome Doubling for Enhancement of Quality Traits in Ornamental Plants. 38
31261798 2019
50
Small, but surprisingly repetitive genomes: transposon expansion and not polyploidy has driven a doubling in genome size in a metazoan species complex. 38
31174483 2019

Variations for Polyploidy

Expression for Polyploidy

Search GEO for disease gene expression data for Polyploidy.

Pathways for Polyploidy

Pathways related to Polyploidy according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.08 TP53 PLK1 CDK1 BUB1 AURKB
2
Show member pathways
12.66 TP73 TP53 CDK1 AURKB
3
Show member pathways
12.29 PLK1 CDK1 BUB1 AURKB
4
Show member pathways
12.11 TP73 TP53 CDK1
5
Show member pathways
12.08 PLK1 CDK1 BUB1
6 12.06 TP53 PLK1 CDK1 BUB1
7
Show member pathways
11.59 TP73 TP53 CDK1
8 11.57 TP73 TP53 PLK1 CDK1 AURKC AURKB
9 11.33 PLK1 CDK1
10
Show member pathways
11.32 PLK1 CDK1 BUB1
11
Show member pathways
11.25 TP53 CDK1
12 11.21 TP53 PLK1 CDK1
13 11.16 CDK1 BUB1 AURKB
14
Show member pathways
11.14 PLK1 CDK1
15 11.1 CDK1 AURKB
16
Show member pathways
11.09 BUB1 AURKC AURKB
17 11.08 TP53 CDK1
18 11.05 TP53 AURKB
19 10.99 PLK1 CDK1 BUB1 AURKB
20 10.9 PLK1 CDK1 AURKB
21
Show member pathways
10.85 TP73 TP53
22 10.77 TP53 CDK1

GO Terms for Polyploidy

Cellular components related to Polyploidy according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.99 TP73 TP53 PLK1 CDK1 BUB1 AURKB
2 chromosome GO:0005694 9.78 PLK1 BUB1 AURKC AURKB
3 spindle GO:0005819 9.67 PLK1 CDK1 AURKC AURKB
4 kinetochore GO:0000776 9.63 PLK1 BUB1 AURKB
5 midbody GO:0030496 9.62 PLK1 CDK1 AURKC AURKB
6 spindle pole centrosome GO:0031616 9.49 AURKC AURKB
7 chromosome, centromeric region GO:0000775 9.46 PLK1 BUB1 AURKC AURKB
8 chromosome passenger complex GO:0032133 9.43 AURKC AURKB
9 spindle midzone GO:0051233 9.43 PLK1 AURKC AURKB
10 condensed nuclear chromosome outer kinetochore GO:0000942 9.4 PLK1 BUB1
11 condensed nuclear chromosome, centromeric region GO:0000780 9.13 PLK1 AURKC AURKB
12 spindle microtubule GO:0005876 8.92 PLK1 CDK1 AURKC AURKB

Biological processes related to Polyploidy according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.91 TP73 TP53 CDK1 BUB1
2 regulation of apoptotic process GO:0042981 9.81 TP73 TP53 ALK
3 cell division GO:0051301 9.77 PLK1 CDK1 BUB1 AURKC AURKB
4 negative regulation of apoptotic process GO:0043066 9.75 TP53 PLK1 CDK1
5 phosphorylation GO:0016310 9.73 PLK1 CDK1 BUB1 AURKC AURKB ALK
6 activation of MAPK activity GO:0000187 9.72 TP73 CDK1 ALK
7 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.66 TP53 CDK1
8 cellular response to UV GO:0034644 9.65 TP53 AURKB
9 mitotic spindle organization GO:0007052 9.65 AURKC AURKB
10 regulation of mitotic cell cycle GO:0007346 9.65 TP73 PLK1
11 regulation of signal transduction by p53 class mediator GO:1901796 9.65 TP73 TP53 AURKB
12 centrosome cycle GO:0007098 9.64 PLK1 CDK1
13 response to organonitrogen compound GO:0010243 9.63 TP73 CDK1
14 positive regulation of cytokinesis GO:0032467 9.63 AURKC AURKB
15 protein phosphorylation GO:0006468 9.63 PLK1 CDK1 BUB1 AURKC AURKB ALK
16 protein tetramerization GO:0051262 9.62 TP73 TP53
17 cell aging GO:0007569 9.62 TP53 CDK1
18 positive regulation of cell cycle arrest GO:0071158 9.61 TP73 TP53
19 regulation of cytokinesis GO:0032465 9.61 PLK1 AURKC AURKB
20 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.6 TP73 TP53
21 positive regulation of protein localization to nucleus GO:1900182 9.59 PLK1 CDK1
22 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.58 TP73 TP53
23 anaphase-promoting complex-dependent catabolic process GO:0031145 9.58 PLK1 CDK1 AURKB
24 regulation of chromosome segregation GO:0051983 9.57 BUB1 AURKB
25 mitotic nuclear envelope disassembly GO:0007077 9.56 PLK1 CDK1
26 protein localization to kinetochore GO:0034501 9.54 CDK1 AURKB
27 mitotic spindle midzone assembly GO:0051256 9.52 AURKC AURKB
28 histone modification GO:0016570 9.51 AURKC AURKB
29 mitotic spindle assembly checkpoint GO:0007094 9.5 PLK1 BUB1 AURKB
30 attachment of spindle microtubules to kinetochore GO:0008608 9.49 AURKC AURKB
31 regulation of cell cycle G2/M phase transition GO:1902749 9.46 TP53 PLK1
32 cell proliferation GO:0008283 9.35 TP53 CDK1 BUB1 AURKB ALK
33 cell cycle GO:0007049 9.17 TP73 TP53 PLK1 CDK1 BUB1 AURKC

Molecular functions related to Polyploidy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity GO:0016740 9.85 PLK1 CDK1 BUB1 AURKC AURKB ALK
2 ATP binding GO:0005524 9.7 TP53 PLK1 CDK1 BUB1 AURKC AURKB
3 protein serine/threonine kinase activity GO:0004674 9.65 PLK1 CDK1 BUB1 AURKC AURKB
4 p53 binding GO:0002039 9.43 TP73 TP53
5 kinase activity GO:0016301 9.43 PLK1 CDK1 BUB1 AURKC AURKB ALK
6 protein serine/threonine/tyrosine kinase activity GO:0004712 9.4 AURKC AURKB
7 histone serine kinase activity GO:0035174 9.32 AURKC AURKB
8 protein kinase activity GO:0004672 9.1 PLK1 CDK1 BUB1 AURKC AURKB ALK

Sources for Polyploidy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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