MCID: PLY100
MIFTS: 40

Polyploidy

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Polyploidy

MalaCards integrated aliases for Polyploidy:

Name: Polyploidy 58

Classifications:

Orphanet: 58  
Developmental anomalies during embryogenesis


External Ids:

MESH via Orphanet 44 D011123
ICD10 via Orphanet 33 Q92.7
UMLS via Orphanet 72 C0032578
Orphanet 58 ORPHA96321

Summaries for Polyploidy

MalaCards based summary : Polyploidy is related to breast adenocarcinoma and mantle cell lymphoma. An important gene associated with Polyploidy is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Cell Cycle, Mitotic and Regulation of TP53 Activity. Affiliated tissues include liver, breast and heart, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Wikipedia : 74 Polyploidy is the state of a cell or organism having more than two paired (homologous) sets of... more...

Related Diseases for Polyploidy

Diseases related to Polyploidy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 breast adenocarcinoma 29.1 TP73 TP53 CDK1
2 mantle cell lymphoma 29.0 TP53 PIM1 CDK1
3 leukemia, acute myeloid 28.2 TP53 PLK1 PIM1 CDK1 AURKB
4 tetraploidy 12.1
5 triploidy 12.0
6 spermatogenic failure 5 11.5
7 hypomelanosis of ito 11.2
8 papillomatosis, confluent and reticulated 10.2
9 lymphoma 10.2
10 48,xyyy 10.2
11 hair whorl 10.2
12 autoimmune lymphoproliferative syndrome 10.2
13 leukemia 10.2
14 b-cell lymphoma 10.2
15 uterine corpus serous adenocarcinoma 10.1 TP53 AURKB
16 hyperinsulinemic hypoglycemia, familial, 3 10.1 AURKC AURKB
17 nondisjunction 10.1
18 polykaryocytosis inducer 10.1
19 retinoblastoma 10.1
20 acute promyelocytic leukemia 10.1
21 myelodysplastic syndrome 10.1
22 diffuse large b-cell lymphoma 10.1
23 hermaphroditism 10.1
24 familial retinoblastoma 10.1
25 infertility 10.1
26 47,xyy 10.1
27 gigantism 10.1
28 ulcerative stomatitis 10.0 TP73 TP53
29 myelofibrosis 10.0
30 osteogenic sarcoma 10.0
31 papilloma of choroid plexus 10.0
32 barrett esophagus 10.0
33 pachyonychia congenita 3 10.0
34 polycystic kidney disease 10.0
35 goiter 10.0
36 squamous cell papilloma 10.0
37 melanoma 10.0
38 papilloma 10.0
39 glioblastoma multiforme 10.0
40 atypical choroid plexus papilloma 10.0
41 liver disease 10.0
42 hyperglycemia 10.0
43 hemolytic anemia 10.0
44 adenoma 10.0
45 myeloid leukemia 10.0
46 autosomal dominant polycystic kidney disease 10.0
47 chromosomal triplication 10.0
48 familial hypertension 10.0
49 neurofibrosarcoma 10.0 TP73 TP53
50 anal squamous cell carcinoma 10.0 TP73 TP53

Graphical network of the top 20 diseases related to Polyploidy:



Diseases related to Polyploidy

Symptoms & Phenotypes for Polyploidy

GenomeRNAi Phenotypes related to Polyploidy according to GeneCards Suite gene sharing:

26 (show all 32)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 10.88 BUB1 CDK1 PLK1 PIM1
2 Decreased substrate adherent cell growth GR00193-A-2 10.88 BUB1 PLK1 PIM1 AURKB
3 Decreased substrate adherent cell growth GR00193-A-3 10.88 BUB1 CDK1 PLK1
4 Decreased substrate adherent cell growth GR00193-A-4 10.88 BUB1 PLK1 AURKB AURKC
5 Decreased viability GR00055-A-2 10.66 PLK1 AURKC
6 Decreased viability GR00173-A 10.66 PLK1
7 Decreased viability GR00221-A-2 10.66 PIM1 PLK1
8 Decreased viability GR00221-A-3 10.66 PIM1 AURKC
9 Decreased viability GR00221-A-4 10.66 AURKC
10 Decreased viability GR00231-A 10.66 PIM1 PLK1
11 Decreased viability GR00240-S-1 10.66 PLK1
12 Decreased viability GR00301-A 10.66 PLK1 AURKC BUB1 CDK1
13 Decreased viability GR00342-S-1 10.66 AURKC
14 Decreased viability GR00381-A-1 10.66 AURKC
15 Decreased viability GR00402-S-2 10.66 PIM1 PLK1 AURKC BUB1 CDK1
16 Decreased cell migration GR00055-A-1 9.86 AURKC CDK1 PIM1 PLK1
17 Effect on mitosis GR00257-A-2 9.78 AURKB AURKC BUB1 PLK1
18 Condensed cis-Golgi GR00365-A 9.75 AURKB BUB1 CDK1
19 Decreased CDKN1A mRNA expression GR00389-S-1 9.74 TP53
20 Decreased CDKN1A mRNA expression GR00389-S-2 9.74 PLK1 TP53
21 Increased cell number in S GR00096-A 9.73 AURKB BUB1 CDK1 PLK1
22 Decreased cella89culturea89derived Hepatitis C virus (HCVcc; Luca89Jc1) infection GR00234-A-2 9.72 AURKB CDK1 PLK1
23 Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection GR00234-A-1 9.71 AURKB CDK1 PLK1
24 Increased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 9.67 AURKB AURKC CDK1 PIM1
25 Increased cell viability after pRB stimulation GR00230-A-1 9.58 BUB1 CDK1 PIM1
26 Decreased TP53 mRNA expression GR00389-S-5 9.51 PLK1 TP53
27 Increased BBC3 mRNA expression GR00389-S-4 9.46 PLK1 TP53
28 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.46 CDK1 PLK1 TP53 TP73
29 Increased proliferation GR00094-A 9.32 BUB1 TP53
30 Increased TP53 mRNA expression GR00389-S-6 9.26 PLK1 TP53
31 Increased viability with TRAIL GR00154-A 8.96 BUB1 PLK1
32 Misorientated spindle GR00256-A 8.62 AURKC PLK1

MGI Mouse Phenotypes related to Polyploidy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.7 AURKB BUB1 CDK1 PIM1 PLK1 TP53
2 neoplasm MP:0002006 9.43 AURKB BUB1 CDK1 PLK1 TP53 TP73
3 reproductive system MP:0005389 9.1 AURKB AURKC BUB1 CDK1 TP53 TP73

Drugs & Therapeutics for Polyploidy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparaison de la Chromo Endoscopie Virtuelle FICE (Fujinon Intelligent Chromoendoscopy) Avec la Coloscopie Conventionnelle Dans la détection de la Dysplasie Chez Patients Porteurs de Recto Colite ulcéro hémorragique (RCH). Unknown status NCT00816491
2 Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics Unknown status NCT03325517
3 Application of Ultrasensitive Chromosomal Aneuploidy Detection (UCAD) as a Surrogate Biomarker of Minimal Residual Diseases for Multiple Myeloma Patients Recruiting NCT04122092
4 Ultrasensitive Chromosomal Aneuploidy Detection (UCAD) in Urine Exfoliated Cells for Diagnosis of Urothelial Carcinoma in in Urine Exfoliated Cells Recruiting NCT03998371

Search NIH Clinical Center for Polyploidy

Genetic Tests for Polyploidy

Anatomical Context for Polyploidy

MalaCards organs/tissues related to Polyploidy:

40
Liver, Breast, Heart, Smooth Muscle, Lung, Prostate, Kidney

Publications for Polyploidy

Articles related to Polyploidy:

(show top 50) (show all 3789)
# Title Authors PMID Year
1
Identification of phytic acid mutants in oilseed rape (Brassica napus) by large-scale screening of mutant populations through amplicon sequencing. 61
31651044 2020
2
Femtosecond laser-induced blastomere fusion results in embryo tetraploidy by common metaphase plate formation. 61
32027865 2020
3
Polyploidy spectrum: a new marker in HCC classification. 61
30979717 2020
4
Ploidy affects the seed, dormancy and seedling characteristics of a perennial grass, conferring an advantage in stressful climates. 61
32011086 2020
5
ddRAD analyses reveal a credible phylogenetic relationship of the four main genera of Bambusa-Dendrocalamus-Gigantochloa complex (Poaceae: Bambusoideae). 61
32028031 2020
6
Interventions in WNT Signaling to Induce Cardiomyocyte Proliferation: Crosstalk with Other Pathways. 61
31757861 2020
7
Polyploidy promotes species diversification of Allium through ecological shifts. 61
31394010 2020
8
Differential properties of mitosis-associated events following CHK1 and WEE1 inhibitor treatments in human tongue carcinoma cells. 61
31738907 2020
9
A Single, Shared Triploidy in Three Species of Parasitic Nematodes. 61
31694855 2020
10
Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity but Develop Fewer Tumors Following Chronic Liver Injury. 61
31972235 2020
11
Radiation-induced alterations in immunogenicity of a murine pancreatic ductal adenocarcinoma cell line. 61
31959787 2020
12
Genetic Contribution of Paleopolyploidy to Adaptive Evolution in Angiosperms. 61
31678615 2020
13
Transcriptomic Dissection of Hepatocyte Heterogeneity: Linking Ploidy, Zonation, and Stem/Progenitor Cell Characteristics. 61
31493546 2020
14
Broad Distribution of Hepatocyte Proliferation in Liver Homeostasis and Regeneration. 61
31866223 2020
15
For things to stay the same, things must change - Polyploidy and pollen tube growth rates. 61
31957784 2020
16
The influence of experimentally induced polyploidy on the relationships between endopolyploidy and plant function in Arabidopsis thaliana. 61
31988723 2020
17
Mammalian egg coat modifications and the block to polyspermy. 61
32003503 2020
18
Robust Cytonuclear Coordination of Transcription in Nascent Arabidopsis thaliana Autopolyploids. 61
32012851 2020
19
Evolution of small RNA expression following hybridization and allopolyploidization: insights from Spartina species (Poaceae, Chloridoideae). 61
31748889 2020
20
Determinants of geographic range size in plants. 61
31901139 2020
21
PolyCluster: Minimum Fragment Disagreement Clustering for Polyploid Phasing. 61
30040655 2020
22
Sequential Paleotetraploidization shaped the carrot genome. 61
32005164 2020
23
Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction. 61
31917811 2020
24
Characterization of a Saccharum spontaneum with a basic chromosome number of x = 10 provides new insights on genome evolution in genus Saccharum. 61
31587087 2020
25
Genome and Karyotype Reorganization after Whole Genome Duplication in Free-Living Flatworms of the Genus Macrostomum. 61
31968653 2020
26
Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy. 61
31530649 2019
27
Ancestral Eukaryotes Reproduced Asexually, Facilitated by Polyploidy: A Hypothesis. 61
31667871 2019
28
Polyploidy remodels fruit metabolism by modifying carbon source utilization and metabolic flux in Ponkan mandarin (Citrus reticulata Blanco). 61
31623787 2019
29
INDUCED POLYPLOIDY AND SORTING OF DAMAGED DNA BY MICRONUCLEATION IN RADIORESISTANT RAT LIVER EPITHELIAL STEM-LIKE CELLS EXPOSED TO X-RAYS. 61
31841469 2019
30
Does reproductive assurance explain the incidence of polyploidy in plants and animals? 61
31883115 2019
31
Phylotranscriptomic Analyses Reveal Asymmetrical Gene Duplication Dynamics and Signatures of Ancient Polyploidy in Mints. 61
31687761 2019
32
Distinguishing successive ancient polyploidy levels based on genome-internal syntenic alignment. 61
31842736 2019
33
The C-Fern (Ceratopteris richardii) genome: insights into plant genome evolution with the first partial homosporous fern genome assembly. 61
31796775 2019
34
Combined effects of dosage compensation and incomplete dominance on gene expression in triploid cyprinids. 61
31883002 2019
35
Residual Diploidy in Polyploid Tissues: A Cellular State with Enhanced Proliferative Capacity for Tissue Regeneration? 61
31608782 2019
36
Rhodoccoccus erythropolis Is Different from Other Members of Actinobacteria: Monoploidy, Overlapping Replication Cycle, and Unique Segregation Pattern. 61
31570531 2019
37
Camelina: A History of Polyploidy, Chromosome Shattering, and Recovery. 61
31562214 2019
38
Genome duplication effects on functional traits and fitness are genetic context and species dependent: studies of synthetic polyploid Fragaria. 61
31732972 2019
39
Cell-Cycle Asynchrony Generates DNA Damage at Mitotic Entry in Polyploid Cells. 61
31708395 2019
40
Unraveling cis and trans regulatory evolution during cotton domestication. 61
31776348 2019
41
The Chromatin Extrusion Phenomenon in Amoeba proteus Cell Cycle. 61
31691412 2019
42
Evolutionary associations between polyploidy, clonal reproduction, and perenniality in the angiosperms. 61
31215649 2019
43
Performance of gene expression analyses using de novo assembled transcripts in polyploid species. 61
31400193 2019
44
Autopolyploidy alters nodule-level interactions in the legume-rhizobium mutualism. 61
31721161 2019
45
Chloroplast Genome Sequence of Artemisia scoparia: Comparative Analyses and Screening of Mutational Hotspots. 61
31698805 2019
46
Distinct functional roles for hopanoid composition in the chemical tolerance of Zymomonas mobilis. 61
31468587 2019
47
Interaction among ploidy, breeding system and lineage diversification. 61
31617595 2019
48
Exposure to acrylamide inhibits uterine decidualization via suppression of cyclin D3/p21 and apoptosis in mice. 61
31818667 2019
49
Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers. 61
31740746 2019
50
Genome size variation at constant chromosome number is not correlated with repetitive DNA dynamism in Anacyclus (Asteraceae). 61
31697800 2019

Variations for Polyploidy

Expression for Polyploidy

Search GEO for disease gene expression data for Polyploidy.

Pathways for Polyploidy

Pathways related to Polyploidy according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.08 TP53 PLK1 CDK1 BUB1 AURKB
2
Show member pathways
12.66 TP73 TP53 CDK1 AURKB
3
Show member pathways
12.29 PLK1 CDK1 BUB1 AURKB
4
Show member pathways
12.11 TP73 TP53 CDK1
5
Show member pathways
12.08 PLK1 CDK1 BUB1
6 12.06 TP53 PLK1 CDK1 BUB1
7
Show member pathways
11.59 TP73 TP53 CDK1
8 11.57 TP73 TP53 PLK1 CDK1 AURKC AURKB
9 11.33 PLK1 CDK1
10
Show member pathways
11.32 PLK1 CDK1 BUB1
11
Show member pathways
11.25 TP53 CDK1
12 11.21 TP53 PLK1 CDK1
13 11.16 CDK1 BUB1 AURKB
14
Show member pathways
11.14 PLK1 CDK1
15 11.1 CDK1 AURKB
16
Show member pathways
11.09 BUB1 AURKC AURKB
17 11.08 TP53 CDK1
18 11.05 TP53 AURKB
19 10.99 PLK1 CDK1 BUB1 AURKB
20 10.9 PLK1 CDK1 AURKB
21
Show member pathways
10.85 TP73 TP53
22 10.77 TP53 CDK1

GO Terms for Polyploidy

Cellular components related to Polyploidy according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.13 TP73 TP53 PLK1 PIM1 CDK1 BUB1
2 cytosol GO:0005829 10.08 TP73 TP53 PLK1 PIM1 CDK1 BUB1
3 nucleoplasm GO:0005654 10.04 TP73 TP53 PLK1 PIM1 CDK1 BUB1
4 chromosome GO:0005694 9.78 PLK1 BUB1 AURKC AURKB
5 spindle GO:0005819 9.67 PLK1 CDK1 AURKC AURKB
6 kinetochore GO:0000776 9.63 PLK1 BUB1 AURKB
7 midbody GO:0030496 9.62 PLK1 CDK1 AURKC AURKB
8 spindle pole centrosome GO:0031616 9.51 AURKC AURKB
9 chromosome, centromeric region GO:0000775 9.46 PLK1 BUB1 AURKC AURKB
10 chromosome passenger complex GO:0032133 9.43 AURKC AURKB
11 spindle midzone GO:0051233 9.43 PLK1 AURKC AURKB
12 condensed nuclear chromosome outer kinetochore GO:0000942 9.4 PLK1 BUB1
13 condensed nuclear chromosome, centromeric region GO:0000780 9.13 PLK1 AURKC AURKB
14 spindle microtubule GO:0005876 8.92 PLK1 CDK1 AURKC AURKB

Biological processes related to Polyploidy according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.88 TP53 PLK1 PIM1 CDK1
2 response to drug GO:0042493 9.83 TP73 TP53 CDK1
3 apoptotic process GO:0006915 9.83 TP73 TP53 PIM1 CDK1 BUB1
4 cell division GO:0051301 9.77 PLK1 CDK1 BUB1 AURKC AURKB
5 regulation of signal transduction by p53 class mediator GO:1901796 9.74 TP73 TP53 AURKB
6 phosphorylation GO:0016310 9.73 PLK1 PIM1 CDK1 BUB1 AURKC AURKB
7 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.66 TP53 CDK1
8 cellular response to UV GO:0034644 9.65 TP53 AURKB
9 regulation of mitotic cell cycle GO:0007346 9.65 TP73 PLK1
10 anaphase-promoting complex-dependent catabolic process GO:0031145 9.65 PLK1 CDK1 AURKB
11 mitotic spindle organization GO:0007052 9.64 AURKC AURKB
12 centrosome cycle GO:0007098 9.64 PLK1 CDK1
13 positive regulation of cardiac muscle cell proliferation GO:0060045 9.63 PIM1 CDK1
14 positive regulation of cytokinesis GO:0032467 9.63 AURKC AURKB
15 protein phosphorylation GO:0006468 9.63 PLK1 PIM1 CDK1 BUB1 AURKC AURKB
16 protein tetramerization GO:0051262 9.62 TP73 TP53
17 response to organonitrogen compound GO:0010243 9.62 TP73 CDK1
18 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.61 TP73 TP53
19 cell aging GO:0007569 9.61 TP53 CDK1
20 positive regulation of cell cycle arrest GO:0071158 9.6 TP73 TP53
21 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.59 TP73 TP53
22 positive regulation of protein localization to nucleus GO:1900182 9.58 PLK1 CDK1
23 regulation of cytokinesis GO:0032465 9.58 PLK1 AURKC AURKB
24 regulation of chromosome segregation GO:0051983 9.56 BUB1 AURKB
25 mitotic nuclear envelope disassembly GO:0007077 9.55 PLK1 CDK1
26 protein localization to kinetochore GO:0034501 9.54 CDK1 AURKB
27 attachment of spindle microtubules to kinetochore GO:0008608 9.52 AURKC AURKB
28 histone modification GO:0016570 9.51 AURKC AURKB
29 mitotic spindle assembly checkpoint GO:0007094 9.5 PLK1 BUB1 AURKB
30 mitotic spindle midzone assembly GO:0051256 9.49 AURKC AURKB
31 regulation of cell cycle G2/M phase transition GO:1902749 9.46 TP53 PLK1
32 cell proliferation GO:0008283 9.35 TP53 PIM1 CDK1 BUB1 AURKB
33 cell cycle GO:0007049 9.23 TP73 TP53 PLK1 PIM1 CDK1 BUB1

Molecular functions related to Polyploidy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity GO:0016740 9.88 PLK1 PIM1 CDK1 BUB1 AURKC AURKB
2 ATP binding GO:0005524 9.8 TP53 PLK1 PIM1 CDK1 BUB1 AURKC
3 kinase activity GO:0016301 9.63 PLK1 PIM1 CDK1 BUB1 AURKC AURKB
4 protein serine/threonine/tyrosine kinase activity GO:0004712 9.43 AURKC AURKB
5 protein kinase activity GO:0004672 9.43 PLK1 PIM1 CDK1 BUB1 AURKC AURKB
6 MDM2/MDM4 family protein binding GO:0097371 9.37 TP73 TP53
7 histone serine kinase activity GO:0035174 9.32 AURKC AURKB
8 protein serine/threonine kinase activity GO:0004674 9.1 PLK1 PIM1 CDK1 BUB1 AURKC AURKB

Sources for Polyploidy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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