MCID: PLY100
MIFTS: 40

Polyploidy

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Polyploidy

MalaCards integrated aliases for Polyploidy:

Name: Polyploidy 58

Classifications:

Orphanet: 58  
Developmental anomalies during embryogenesis


External Ids:

MESH via Orphanet 44 D011123
ICD10 via Orphanet 33 Q92.7
UMLS via Orphanet 72 C0032578
Orphanet 58 ORPHA96321

Summaries for Polyploidy

MalaCards based summary : Polyploidy is related to breast adenocarcinoma and mantle cell lymphoma. An important gene associated with Polyploidy is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Cell Cycle, Mitotic and Regulation of TP53 Activity. Affiliated tissues include liver, smooth muscle and breast, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Wikipedia : 74 Polyploidy is a condition in which the cells of an organism have more than two paired (homologous) sets... more...

Related Diseases for Polyploidy

Diseases related to Polyploidy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
# Related Disease Score Top Affiliating Genes
1 breast adenocarcinoma 29.1 TP73 TP53 CDK1
2 mantle cell lymphoma 29.0 TP53 PIM1 CDK1
3 leukemia, acute myeloid 28.2 TP53 PLK1 PIM1 CDK1 AURKB
4 tetraploidy 12.0
5 spermatogenic failure 5 11.6
6 hypomelanosis of ito 11.2
7 triploidy 10.9
8 papillomatosis, confluent and reticulated 10.2
9 48,xyyy 10.2
10 hair whorl 10.2
11 autoimmune lymphoproliferative syndrome 10.2
12 lymphoma 10.2
13 leukemia 10.2
14 b-cell lymphoma 10.2
15 myeloid leukemia 10.2
16 nondisjunction 10.1
17 polykaryocytosis inducer 10.1
18 retinoblastoma 10.1
19 acute promyelocytic leukemia 10.1
20 myelodysplastic syndrome 10.1
21 diffuse large b-cell lymphoma 10.1
22 hermaphroditism 10.1
23 familial retinoblastoma 10.1
24 infertility 10.1
25 47,xyy 10.1
26 gigantism 10.1
27 endometrial serous adenocarcinoma 10.1 TP53 AURKB
28 ulcerative stomatitis 10.0 TP73 TP53
29 myelofibrosis 10.0
30 osteogenic sarcoma 10.0
31 papilloma of choroid plexus 10.0
32 barrett esophagus 10.0
33 pachyonychia congenita 3 10.0
34 polycystic kidney disease 10.0
35 goiter 10.0
36 squamous cell papilloma 10.0
37 melanoma 10.0
38 papilloma 10.0
39 glioblastoma multiforme 10.0
40 atypical choroid plexus papilloma 10.0
41 liver disease 10.0
42 hyperglycemia 10.0
43 hemolytic anemia 10.0
44 adenoma 10.0
45 autosomal dominant polycystic kidney disease 10.0
46 chromosomal triplication 10.0
47 familial hypertension 10.0
48 anal squamous cell carcinoma 10.0 TP73 TP53
49 neurofibrosarcoma 10.0 TP73 TP53
50 cholestasis, intrahepatic, of pregnancy, 1 9.9 BUB1 AURKB

Graphical network of the top 20 diseases related to Polyploidy:



Diseases related to Polyploidy

Symptoms & Phenotypes for Polyploidy

GenomeRNAi Phenotypes related to Polyploidy according to GeneCards Suite gene sharing:

26 (show all 28)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 10.67 BUB1 CDK1 PLK1 PIM1
2 Decreased substrate adherent cell growth GR00193-A-2 10.67 BUB1 PLK1 PIM1 AURKB
3 Decreased substrate adherent cell growth GR00193-A-3 10.67 BUB1 CDK1 PLK1
4 Decreased substrate adherent cell growth GR00193-A-4 10.67 BUB1 PLK1 AURKB AURKC
5 Decreased viability GR00055-A-1 10.45 PLK1 AURKC
6 Decreased viability GR00055-A-2 10.45 PLK1 AURKC
7 Decreased viability GR00055-A-3 10.45 PLK1
8 Decreased viability GR00154-A 10.45 PLK1
9 Decreased viability GR00173-A 10.45 PLK1
10 Decreased viability GR00221-A-2 10.45 PIM1 PLK1
11 Decreased viability GR00221-A-3 10.45 PIM1 AURKC
12 Decreased viability GR00221-A-4 10.45 AURKC
13 Decreased viability GR00231-A 10.45 PLK1
14 Decreased viability GR00240-S-1 10.45 PLK1
15 Decreased viability GR00249-S 10.45 PLK1 BUB1 CDK1
16 Decreased viability GR00301-A 10.45 PLK1 AURKC BUB1 CDK1
17 Decreased viability GR00342-S-1 10.45 AURKC
18 Decreased viability GR00381-A-1 10.45 AURKC
19 Decreased viability GR00386-A-1 10.45 PLK1
20 Decreased viability GR00402-S-2 10.45 PLK1 AURKC CDK1
21 Decreased cell–culture–derived Hepatitis C virus (HCVcc; Luc–Jc1) infection GR00234-A-2 9.61 AURKB CDK1 PLK1
22 Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection GR00234-A-1 9.58 AURKB CDK1 PLK1
23 Decreased TP53 mRNA expression GR00389-S-5 9.56 PLK1 TP53
24 Decreased TP53 mRNA expression GR00389-S-6 9.56 PLK1 TP53
25 Decreased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 9.54 AURKB CDK1 PIM1
26 Decreased cell migration GR00055-A-1 9.16 PIM1
27 Increased proliferation GR00094-A 8.96 BUB1 TP53
28 Misorientated spindle GR00256-A 8.62 AURKC PLK1

MGI Mouse Phenotypes related to Polyploidy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.7 AURKB BUB1 CDK1 PIM1 PLK1 TP53
2 neoplasm MP:0002006 9.43 AURKB BUB1 CDK1 PLK1 TP53 TP73
3 reproductive system MP:0005389 9.1 AURKB AURKC BUB1 CDK1 TP53 TP73

Drugs & Therapeutics for Polyploidy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparaison de la Chromo Endoscopie Virtuelle FICE (Fujinon Intelligent Chromoendoscopy) Avec la Coloscopie Conventionnelle Dans la détection de la Dysplasie Chez Patients Porteurs de Recto Colite ulcéro hémorragique (RCH). Unknown status NCT00816491
2 Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics Unknown status NCT03325517
3 Ultrasensitive Chromosomal Aneuploidy Detection (UCAD) in Urine Exfoliated Cells for Diagnosis of Urothelial Carcinoma in in Urine Exfoliated Cells Recruiting NCT03998371
4 Application of Ultrasensitive Chromosomal Aneuploidy Detection (UCAD) as a Surrogate Biomarker of Minimal Residual Diseases for Multiple Myeloma Patients Recruiting NCT04122092

Search NIH Clinical Center for Polyploidy

Genetic Tests for Polyploidy

Anatomical Context for Polyploidy

MalaCards organs/tissues related to Polyploidy:

40
Liver, Smooth Muscle, Breast, Lung, Testes, Bone, Heart

Publications for Polyploidy

Articles related to Polyploidy:

(show top 50) (show all 3883)
# Title Authors PMID Year
1
Evolution of Lomandroideae: Multiple origins of polyploidy and biome occupancy in Australia. 61
32304826 2020
2
Autophagy inhibition by reversine and its suppressive effects on human hepatocellular carcinoma cells. 61
32456791 2020
3
The C- and G-value paradox with polyploidy, repeatomes, introns, phenomes and cell economy. 61
32445179 2020
4
Does reproductive assurance explain the incidence of polyploidy in plants and animals? 61
31883115 2020
5
Cyanobacterial multi-copy chromosomes and their replication. 61
32157949 2020
6
Hyper-polyploid embryos survive after implantation in mice. 61
32151294 2020
7
Destruction of a Microtubule-Bound MYC Reservoir during Mitosis Contributes to Vincristine's Anticancer Activity. 61
32161139 2020
8
Impact of genome duplication on secondary metabolite composition in non-cultivated species: A systematic meta-analysis. 61
32504537 2020
9
Reduced chromatin accessibility underlies gene expression differences in homologous chromosome arms of diploid Aegilops tauschii and hexaploid wheat. 61
32562491 2020
10
Secondary origin, hybridization and sexual reproduction in a diploid-tetraploid contact zone of the facultatively apomictic orchid Zygopetalum mackayi. 61
32558140 2020
11
Role of NGS and SNP genotyping methods in sugarcane improvement programs. 61
32508157 2020
12
The protected tree Dimorphandra wilsonii (Fabaceae) is a population of inter-specific hybrids: recommendations for conservation in the Brazilian Cerrado/Atlantic Forest ecotone. 61
32277237 2020
13
Hyaluronan-binding protein 1 (HABP1) overexpression triggers induction of senescence in fibroblasts cells. 61
32068317 2020
14
New insights into the evolution of the fern family dennstaedtiaceae from an expanded molecular phylogeny and morphological analysis. 61
32512193 2020
15
Genetic testing on products of conception and its relationship with body mass index. 61
32519011 2020
16
Polyploidy in gymnosperms - Insights into the genomic and evolutionary consequences of polyploidy in Ephedra. 61
32135310 2020
17
The Battle to Sequence the Bread Wheat Genome: A Tale of the Three Kingdoms. 61
32561470 2020
18
Regain of sex determination system and sexual reproduction ability in a synthetic octoploid male fish. 61
32529288 2020
19
DNA synthesis increases during the first hours post-emergence in Anopheles albimanus mosquito midgut. 61
32526289 2020
20
The effects of hybridization and genome doubling in plant evolution via allopolyploidy. 61
32572735 2020
21
Overcoming polyploidy pitfalls: a user guide for effective SNP conversion into KASP markers in wheat. 61
32500260 2020
22
Diving in uncharted waters: an updated genetics toolkit highlights the challenges of polyploidy in landscape genomics analyses. 61
32492285 2020
23
Cyto-genotoxic effects of Pinoxaden on Allium cepa L. roots. 61
32399682 2020
24
Development and characterization of Triticum turgidum - Aegilops comosa and T. turgidum - Ae. markgrafii amphidiploids. 61
32160479 2020
25
Determinants of geographic range size in plants. 61
31901139 2020
26
ddRAD analyses reveal a credible phylogenetic relationship of the four main genera of Bambusa-Dendrocalamus-Gigantochloa complex (Poaceae: Bambusoideae). 61
32028031 2020
27
Engineering Stable Pseudomonas putida S12 by CRISPR for 2,5-Furandicarboxylic Acid (FDCA) Production. 61
32298581 2020
28
Hepatitis B virus X protein enhances the development of liver fibrosis and the expression of genes associated with epithelial-mesenchymal transitions and tumor progenitor cells. 61
31175830 2020
29
Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing. 61
32401198 2020
30
Identification and Evolution of the WUSCHEL-Related Homeobox Protein Family in Bambusoideae. 61
32397500 2020
31
Modifications of fatty acid profile through targeted mutation at BnaFAD2 gene with CRISPR/Cas9-mediated gene editing in Brassica napus. 61
32448919 2020
32
Polyploidy breaks speciation barriers in Australian burrowing frogs Neobatrachus. 61
32392206 2020
33
LRPPRC sustains Yap-P27-mediated cell ploidy and P62-HDAC6-mediated autophagy maturation and suppresses genome instability and hepatocellular carcinomas. 61
32203162 2020
34
Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity But Develop Fewer Hepatocellular Carcinomas Following Chronic Liver Injury. 61
31972235 2020
35
Polyploidy affects the seed, dormancy and seedling characteristics of a perennial grass, conferring an advantage in stressful climates. 61
32011086 2020
36
For things to stay the same, things must change: polyploidy and pollen tube growth rates. 61
31957784 2020
37
Role of cell cycling and polyploidy in placental trophoblast of different mammalian species. 61
32470192 2020
38
Centrosome Abnormalities and Polyploidy in Murine Mammary Carcinomas with Different Degrees of Hormone Responsiveness. 61
32378982 2020
39
Phenotypic delay in the evolution of bacterial antibiotic resistance: Mechanistic models and their implications. 61
32469859 2020
40
Whole genome duplication does not promote common modes of reproductive isolation in Trifolium pratense. 61
32329070 2020
41
Dalayed Effects of Antitumor Drug Paclitaxel on the Hereditary Material and Hemopoietic System of CBA Mice. 61
32488780 2020
42
Genomic diversifications of five Gossypium allopolyploid species and their impact on cotton improvement. 61
32313247 2020
43
IL33 Is a Key Driver of Treatment Resistance of Cancer. 61
32156776 2020
44
A deep dive into the ancestral chromosome number and genome size of flowering plants. 61
32421860 2020
45
Assessment of the cytotoxic and genotoxic potential of pillar[5]arene derivatives by Allium cepa roots and Drosophila melanogaster haemocytes. 61
32078840 2020
46
Biotechnological Interventions for Ginsenosides Production. 61
32252467 2020
47
Sublethal Radiation Affects Antigen Processing and Presentation Genes to Enhance Immunogenicity of Cancer Cells. 61
32272797 2020
48
Exposure to acrylamide inhibits uterine decidualization via suppression of cyclin D3/p21 and apoptosis in mice. 61
31818667 2020
49
Synthetic hybrids of six yeast species. 61
32350251 2020
50
Allopolyploid speciation accompanied by gene flow in a tree fern. 61
32302390 2020

Variations for Polyploidy

Expression for Polyploidy

Search GEO for disease gene expression data for Polyploidy.

Pathways for Polyploidy

Pathways related to Polyploidy according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.08 TP53 PLK1 CDK1 BUB1 AURKB
2
Show member pathways
12.66 TP73 TP53 CDK1 AURKB
3
Show member pathways
12.29 PLK1 CDK1 BUB1 AURKB
4
Show member pathways
12.1 TP73 TP53 CDK1
5
Show member pathways
12.08 PLK1 CDK1 BUB1
6 12.06 TP53 PLK1 CDK1 BUB1
7
Show member pathways
11.59 TP73 TP53 CDK1
8 11.57 TP73 TP53 PLK1 CDK1 AURKC AURKB
9 11.34 PLK1 CDK1
10
Show member pathways
11.32 PLK1 CDK1 BUB1
11
Show member pathways
11.25 TP53 CDK1
12 11.21 TP53 PLK1 CDK1
13 11.16 CDK1 BUB1 AURKB
14
Show member pathways
11.14 PLK1 CDK1
15 11.1 CDK1 AURKB
16
Show member pathways
11.09 BUB1 AURKC AURKB
17 11.08 TP53 CDK1
18 11.06 TP53 AURKB
19 10.99 PLK1 CDK1 BUB1 AURKB
20 10.9 PLK1 CDK1 AURKB
21
Show member pathways
10.85 TP73 TP53
22 10.77 TP53 CDK1

GO Terms for Polyploidy

Cellular components related to Polyploidy according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.13 TP73 TP53 PLK1 PIM1 CDK1 BUB1
2 cytosol GO:0005829 10.09 TP73 TP53 PLK1 PIM1 CDK1 BUB1
3 nucleoplasm GO:0005654 10.02 TP73 TP53 PLK1 PIM1 CDK1 BUB1
4 cytoskeleton GO:0005856 9.93 TP53 PLK1 CDK1 AURKC AURKB
5 chromosome GO:0005694 9.8 PLK1 BUB1 AURKC AURKB
6 spindle GO:0005819 9.67 PLK1 CDK1 AURKC AURKB
7 kinetochore GO:0000776 9.63 PLK1 BUB1 AURKB
8 midbody GO:0030496 9.62 PLK1 CDK1 AURKC AURKB
9 chromosome, centromeric region GO:0000775 9.56 PLK1 BUB1 AURKC AURKB
10 spindle pole centrosome GO:0031616 9.51 AURKC AURKB
11 chromosome passenger complex GO:0032133 9.43 AURKC AURKB
12 condensed nuclear chromosome outer kinetochore GO:0000942 9.4 PLK1 BUB1
13 spindle midzone GO:0051233 9.33 PLK1 AURKC AURKB
14 condensed nuclear chromosome, centromeric region GO:0000780 9.13 PLK1 AURKC AURKB
15 spindle microtubule GO:0005876 8.92 PLK1 CDK1 AURKC AURKB

Biological processes related to Polyploidy according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.88 TP73 TP53 CDK1 BUB1
2 negative regulation of apoptotic process GO:0043066 9.88 TP53 PLK1 PIM1 CDK1
3 response to drug GO:0042493 9.83 TP73 TP53 CDK1
4 apoptotic process GO:0006915 9.8 TP73 TP53 PIM1 CDK1 BUB1
5 cell proliferation GO:0008283 9.74 CDK1 BUB1 AURKB
6 regulation of signal transduction by p53 class mediator GO:1901796 9.73 TP73 TP53 AURKB
7 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.66 TP53 CDK1
8 cellular response to UV GO:0034644 9.65 TP53 AURKB
9 mitotic spindle organization GO:0007052 9.65 AURKC AURKB
10 cell division GO:0051301 9.65 PLK1 CDK1 BUB1 AURKC AURKB
11 centrosome cycle GO:0007098 9.64 PLK1 CDK1
12 positive regulation of cardiac muscle cell proliferation GO:0060045 9.64 PIM1 CDK1
13 positive regulation of cytokinesis GO:0032467 9.63 AURKC AURKB
14 response to organonitrogen compound GO:0010243 9.63 TP73 CDK1
15 anaphase-promoting complex-dependent catabolic process GO:0031145 9.63 PLK1 CDK1 AURKB
16 phosphorylation GO:0016310 9.63 PLK1 PIM1 CDK1 BUB1 AURKC AURKB
17 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.62 TP73 TP53
18 cell aging GO:0007569 9.62 TP53 CDK1
19 positive regulation of cell cycle arrest GO:0071158 9.61 TP73 TP53
20 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.61 TP73 TP53
21 positive regulation of protein localization to nucleus GO:1900182 9.6 PLK1 CDK1
22 protein tetramerization GO:0051262 9.59 TP73 TP53
23 regulation of chromosome segregation GO:0051983 9.55 BUB1 AURKB
24 mitotic nuclear envelope disassembly GO:0007077 9.54 PLK1 CDK1
25 regulation of cytokinesis GO:0032465 9.54 PLK1 AURKC AURKB
26 protein localization to kinetochore GO:0034501 9.52 CDK1 AURKB
27 histone modification GO:0016570 9.51 AURKC AURKB
28 mitotic spindle assembly checkpoint GO:0007094 9.5 PLK1 BUB1 AURKB
29 attachment of spindle microtubules to kinetochore GO:0008608 9.49 AURKC AURKB
30 mitotic spindle midzone assembly GO:0051256 9.48 AURKC AURKB
31 regulation of cell cycle G2/M phase transition GO:1902749 9.43 TP53 PLK1
32 protein phosphorylation GO:0006468 9.43 PLK1 PIM1 CDK1 BUB1 AURKC AURKB
33 cell cycle GO:0007049 9.23 TP73 TP53 PLK1 PIM1 CDK1 BUB1

Molecular functions related to Polyploidy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity GO:0016740 9.91 PLK1 PIM1 CDK1 BUB1 AURKC AURKB
2 nucleotide binding GO:0000166 9.88 PLK1 PIM1 CDK1 BUB1 AURKC AURKB
3 ATP binding GO:0005524 9.8 TP53 PLK1 PIM1 CDK1 BUB1 AURKC
4 kinase activity GO:0016301 9.63 PLK1 PIM1 CDK1 BUB1 AURKC AURKB
5 protein serine/threonine/tyrosine kinase activity GO:0004712 9.46 AURKC AURKB
6 protein kinase activity GO:0004672 9.43 PLK1 PIM1 CDK1 BUB1 AURKC AURKB
7 MDM2/MDM4 family protein binding GO:0097371 9.37 TP73 TP53
8 histone serine kinase activity GO:0035174 9.32 AURKC AURKB
9 protein serine/threonine kinase activity GO:0004674 9.1 PLK1 PIM1 CDK1 BUB1 AURKC AURKB

Sources for Polyploidy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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