MCID: PLY073
MIFTS: 24

Polyposis, Gastric

Categories: Gastrointestinal diseases

Aliases & Classifications for Polyposis, Gastric

MalaCards integrated aliases for Polyposis, Gastric:

Name: Polyposis, Gastric 57 55 73
Gastric Polyposis 29 6

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
polyposis, gastric:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 175020
MedGen 42 C0236048
SNOMED-CT via HPO 69 263681008 78809005 87252009
UMLS 73 C0236048

Summaries for Polyposis, Gastric

MalaCards based summary : Polyposis, Gastric, also known as gastric polyposis, is related to polyposis, skin pigmentation, alopecia, and fingernail changes and gastritis. An important gene associated with Polyposis, Gastric is APC (APC, WNT Signaling Pathway Regulator). The drugs Amoxicillin and Clarithromycin have been mentioned in the context of this disorder. Affiliated tissues include bone and skin, and related phenotype is multiple gastric polyps.

Description from OMIM: 175020

Related Diseases for Polyposis, Gastric

Graphical network of the top 20 diseases related to Polyposis, Gastric:



Diseases related to Polyposis, Gastric

Symptoms & Phenotypes for Polyposis, Gastric

Symptoms via clinical synopsis from OMIM:

57
G I:
multiple gastric polyps

Oncology:
stomach adenocarcinoma propensity


Clinical features from OMIM:

175020

Human phenotypes related to Polyposis, Gastric:

32
# Description HPO Frequency HPO Source Accession
1 multiple gastric polyps 32 HP:0004394

Drugs & Therapeutics for Polyposis, Gastric

Drugs for Polyposis, Gastric (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
2
Clarithromycin Approved Phase 4 81103-11-9 84029
3
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
4
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
5 Anti-Bacterial Agents Phase 4
6 Anti-Infective Agents Phase 4
7 Cytochrome P-450 Enzyme Inhibitors Phase 4
8 Cytochrome P-450 CYP3A Inhibitors Phase 4
9 Antacids Phase 4
10 Anti-Ulcer Agents Phase 4
11 Proton Pump Inhibitors Phase 4
12 Gastrointestinal Agents Phase 4
13
Midazolam Approved, Illicit Not Applicable 59467-70-8 4192
14
Fentanyl Approved, Illicit, Investigational, Vet_approved Not Applicable 437-38-7 3345
15 Cola Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dual Therapy With High Doses of Ilaprazole and Amoxicillin for Helicobacter Pylori Infection Completed NCT02401477 Phase 4 Ilaprazole + Amoxicillin
2 Effect of H. Pylori Eradication on the Fate of H. Pylori-associated Gastric Polyp Recruiting NCT03065868 Phase 4 H. pylori eradication (Amoxaxillin, Lanston, Clarithromycin)
3 Vonoprazan Study in Patients With Erosive Esophagitis to Evaluate Long-term Safety Active, not recruiting NCT02679508 Phase 4 Vonoprazan;Lansoprazole
4 Magnetic-controlled Capsule Endoscopy vs. Gastroscopy for Detection of Gastric Diseases Completed NCT02219529 Phase 3
5 Remote-controlled Capsule Endoscopy: a Feasibility Study Unknown status NCT01946633 Not Applicable
6 Optimal Procedural Sequence in Same-day Bidirectional Endoscopy: A Prospective Randomized Controlled Study Completed NCT02708212 Not Applicable
7 Endoscopic Resection Multicenter Registry Recruiting NCT03065257
8 Fundic Gland Polyps and Proton Pump Inhibitor (PPI) Drugs Terminated NCT01130363

Search NIH Clinical Center for Polyposis, Gastric

Genetic Tests for Polyposis, Gastric

Genetic tests related to Polyposis, Gastric:

# Genetic test Affiliating Genes
1 Gastric Polyposis 29

Anatomical Context for Polyposis, Gastric

MalaCards organs/tissues related to Polyposis, Gastric:

41
Bone, Skin

Publications for Polyposis, Gastric

Articles related to Polyposis, Gastric:

(show top 50) (show all 77)
# Title Authors Year
1
An unusual cause of anemia : familial hyperplastic gastric polyposis. ( 30350540 )
2018
2
The gastric mucosal-associated microbiome in patients with gastric polyposis. ( 30217998 )
2018
3
FANCA D1359Y mutation in a patient with gastric polyposis and cancer susceptibility: A case report and review of literature. ( 30344425 )
2018
4
Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) - a rare recently described gastric polyposis syndrome - report of a case. ( 29141268 )
2017
5
RECURRENT GASTRIC POLYPOSIS IN A PATIENT USING ANTIEPILEPTIC DRUGS FOR A LONG TIME. ( 28362663 )
2017
6
Multiple Myeloma Causing Gastric Polyposis. ( 28848770 )
2017
7
Massive Gastric Polyposis Associated with Juvenile Polyposis Syndrome. ( 27301526 )
2016
8
Multiple endocrine neoplasia type 1 with gastric neuroendocrine tumor presented with gastric polyposis. ( 25460558 )
2015
9
Massive gastric polyposis associated with a germline SMAD4 gene mutation. ( 26159157 )
2015
10
Gastric Polyposis: A Rare Cause of Iron Deficiency Anemia in a Patient With Portal Hypertension. ( 26157923 )
2015
11
Total gastrectomy with isoperistaltic jejunal interposition flap for symptomatic management of gastric polyposis from familial adenomatous polyposis. ( 24490047 )
2014
12
Hyperplastic gastric polyposis complicated by a high-grade sarcomatoid malignancy. ( 24839617 )
2014
13
Gastric polyposis associated with portal hypertension. ( 23526873 )
2013
14
A rare gastric polyposis: Cronkhite-Canada syndrome. ( 23021871 )
2012
15
Juvenile polyposis syndrome presenting with familial gastric cancer and massive gastric polyposis. ( 22826269 )
2012
16
The use of ¹⁸F-FDG PET/CT in Cowden syndrome to differentiate multifocal gastric carcinoma from extensive benign gastric polyposis. ( 22310267 )
2012
17
A case of Cowden syndrome diagnosed from multiple gastric polyposis. ( 22371648 )
2012
18
Evaluation of the oncogenic risk of diffuse gastric polyposis. A case report. ( 23130859 )
2012
19
Isolated diffuse hyperplastic gastric polyposis: a rare case. ( 23205366 )
2012
20
Total gastrectomy and pancreaticoduodenectomy for gastric polyposis and duodenal ampullary adenoma in a patient with attenuated familial adenomatous polyposis. ( 21375864 )
2011
21
Sporadic diffuse gastric polyposis: Report of a case. ( 21922371 )
2011
22
Education and imaging. Gastrointestinal: Atypical hyperplastic gastric polyposis: a case report and brief review of the literature. ( 22011301 )
2011
23
Severe bone disease with bilateral femur fracture in a young woman after gastrectomy for gastric polyposis with SMAD4 mutation. ( 19564721 )
2010
24
Hyperplastic gastric polyposis: a rare entity. ( 20399907 )
2010
25
A case of gastric polyposis in antral area of stomach following prolonged proton-pump therapy. ( 20930929 )
2010
26
Degenerative gastric polyposis and pernicious anemia. ( 19505789 )
2009
27
Diagnosis and treatment of Gardner syndrome with gastric polyposis: a case report and review of the literature. ( 18395919 )
2008
28
Isolated diffuse hyperplastic gastric polyposis presenting with severe anemia. ( 18755016 )
2008
29
Multiple myeloma presenting as gastric polyposis. ( 17410432 )
2007
30
Gastric polyposis in familial juvenile polyposis. ( 17719585 )
2007
31
Peutz-Jeghers gastric polyposis. ( 16377337 )
2006
32
Hyperplastic gastric polyposis, hypergastrinaemia and colorectal neoplasia: a description of four cases. ( 14624161 )
2003
33
Juvenile polyposis: massive gastric polyposis is more common in MADH4 mutation carriers than in BMPR1A mutation carriers. ( 12136244 )
2002
34
Diffuse gastric polyposis: report of a case. ( 12517046 )
2002
35
Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice. ( 10773876 )
2000
36
Hamartomatous gastric polyposis in a patient with tuberous sclerosis. ( 10983700 )
2000
37
Tc-99m albumin scintigraphy in protein-losing gastroenteropathy caused by gastric polyposis. ( 9596161 )
1998
38
Gastric polyposis caused by multiple carcinoids and early carcinoma. ( 7665711 )
1995
39
Langerhans cell histiocytosis of the stomach. A cause of granulomatous gastritis and gastric polyposis. ( 7979922 )
1994
40
Juvenile gastric polyposis: reduction in blood- and protein-losing gastropathy with omeprazole. ( 8122663 )
1994
41
Gastric polyposis: onset during long-term therapy with omeprazole. ( 8419774 )
1993
42
Omeprazole and gastric polyposis in humans. ( 8482482 )
1993
43
Gastric polyposis caused by multifocal histiocytosis X. ( 1644344 )
1992
44
Gastric polyposis: onset during long-term therapy with omeprazole. ( 1406434 )
1992
45
Gastric polyposis: onset during long-term therapy with omeprazole. ( 1435464 )
1992
46
Familial gastric polyposis revisited. Autosomal dominant inheritance confirmed. ( 1645228 )
1991
47
Gastric xanthelasma in hyperplastic gastric polyposis. ( 2705875 )
1989
48
Trichobezoar associated with gastric polyposis. ( 3247739 )
1988
49
Gastric polyposis and malignancy. ( 3730784 )
1986
50
Unusual gastric polyposis. ( 7171436 )
1982

Variations for Polyposis, Gastric

ClinVar genetic disease variations for Polyposis, Gastric:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 APC NM_000038.5(APC): c.3927_3931delAAAGA (p.Glu1309Aspfs) deletion Pathogenic rs121913224 GRCh37 Chromosome 5, 112175218: 112175222
2 APC NM_000038.5(APC): c.3927_3931delAAAGA (p.Glu1309Aspfs) deletion Pathogenic rs121913224 GRCh38 Chromosome 5, 112839521: 112839525

Expression for Polyposis, Gastric

Search GEO for disease gene expression data for Polyposis, Gastric.

Pathways for Polyposis, Gastric

GO Terms for Polyposis, Gastric

Sources for Polyposis, Gastric

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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