MCID: PLY021
MIFTS: 33

Polyradiculopathy

Categories: Neuronal diseases

Aliases & Classifications for Polyradiculopathy

MalaCards integrated aliases for Polyradiculopathy:

Name: Polyradiculopathy 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4307
MeSH 44 D011128
NCIt 50 C34934
SNOMED-CT 68 75572007
UMLS 73 C0032586

Summaries for Polyradiculopathy

MalaCards based summary : Polyradiculopathy is related to cauda equina syndrome and chronic polyradiculoneuritis. An important gene associated with Polyradiculopathy is AKR1B1 (Aldo-Keto Reductase Family 1 Member B), and among its related pathways/superpathways is Heart Development. The drugs Mycophenolic acid and Mycophenolate mofetil have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and cervix, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 Radiculopathy, also commonly referred to as pinched nerve, refers to a set of conditions in which one or... more...

Related Diseases for Polyradiculopathy

Diseases related to Polyradiculopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 cauda equina syndrome 11.1
2 chronic polyradiculoneuritis 11.0
3 ossification of the posterior longitudinal ligament of spine 10.4 AVPR2 BMP2
4 spondylolisthesis 10.4 BMP2 IVD
5 spinal cord disease 10.2 AVPR2 HSF4
6 bronchus cancer 10.1 AVPR2 CD6
7 spastic hemiplegia 10.1 CAPN15 HFM1
8 neuropathy 10.0
9 aging 9.9
10 cervicitis 9.9
11 systemic lupus erythematosus 9.8
12 leukemia, acute lymphoblastic 9.8
13 lymphoma 9.8
14 siderosis 9.8
15 lymphoblastic leukemia 9.8
16 lyme disease 9.8
17 guillain-barre syndrome 9.8
18 polyneuropathy 9.8
19 pneumonia 9.8
20 acquired immunodeficiency syndrome 9.8
21 herpes zoster 9.8
22 lupus erythematosus 9.8
23 intracranial hypertension 9.8
24 meningitis 9.8
25 cytomegalovirus infection 9.8
26 superficial siderosis 9.8
27 aortic valve disease 1 9.7 BMP2 NOTCH1
28 amyotrophic lateral sclerosis 1 9.7
29 lymphoma, hodgkin, classic 9.7
30 focal segmental glomerulosclerosis 1 9.7
31 autoimmune lymphoproliferative syndrome, type v 9.7
32 acute lymphocytic leukemia 9.7
33 diabetes mellitus 9.7
34 focal segmental glomerulosclerosis 9.7
35 hematopoietic stem cell transplantation 9.7
36 leukemia 9.7
37 spinal stenosis 9.7
38 amyotrophic neuralgia 9.7
39 st. louis encephalitis 9.7
40 gastroparesis 9.7
41 arachnoiditis 9.7
42 melanoma 9.7
43 pharyngitis 9.7
44 lateral sclerosis 9.7
45 substance abuse 9.7
46 syphilis 9.7
47 myopathy 9.7
48 genital herpes 9.7
49 encephalitis 9.7
50 blastic plasmacytoid dendritic cell 9.7

Graphical network of the top 20 diseases related to Polyradiculopathy:



Diseases related to Polyradiculopathy

Symptoms & Phenotypes for Polyradiculopathy

GenomeRNAi Phenotypes related to Polyradiculopathy according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.86 CAPN15
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.86 NOTCH1 AKR1B1 BMP2 CAPN15
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.86 AKR1B1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.86 CAPN15
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.86 AKR1B1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.86 AKR1B1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.86 NOTCH1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.86 AKR1B1 BMP2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.86 CAPN15
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.86 NOTCH1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.86 NOTCH1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.86 AKR1B1
13 Increased transferrin (TF) endocytosis GR00363-A 9.28 CD6 HSF4 IVD KLK8 ACAN AKR1B1

Drugs & Therapeutics for Polyradiculopathy

Drugs for Polyradiculopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolic acid Approved Phase 3 24280-93-1 446541
2
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
3 Rho(D) Immune Globulin Phase 3
4 gamma-Globulins Phase 3
5 Anti-Bacterial Agents Phase 3
6 Antibiotics, Antitubercular Phase 3
7 Antibodies Phase 3
8 Immunoglobulins Phase 3
9 Immunoglobulins, Intravenous Phase 3
10 Anti-Infective Agents Phase 3
11 Antitubercular Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Interest of Mycophenolate for CIDP Weaning Active, not recruiting NCT02494505 Phase 3 Mycophenolate Mofetil;placebo
2 Peristeen Bowel Irrigation System in Cauda Equina Completed NCT01784328 Not Applicable
3 BLB Study Back or Leg Pain and Bladder Symptoms Study Recruiting NCT03325374
4 Stereotactic Body Radiotherapy Boost After Palliative Radiotherapy for Spinal Cord Compression Not yet recruiting NCT03529708 Not Applicable
5 Post-void Bladder Scanning in Acute Cauda Equina Syndrome Withdrawn NCT02806167 Not Applicable

Search NIH Clinical Center for Polyradiculopathy

Genetic Tests for Polyradiculopathy

Anatomical Context for Polyradiculopathy

MalaCards organs/tissues related to Polyradiculopathy:

41
Spinal Cord, Cervix

Publications for Polyradiculopathy

Articles related to Polyradiculopathy:

(show top 50) (show all 117)
# Title Authors Year
1
Lumbosacral polyradiculopathy after intrathecal chemotherapy in pediatric acute lymphoblastic leukemia. ( 29470812 )
2018
2
Utility of somatosensory evoked potentials in the assessment of response to IVIG in a long-lasting case of chronic immune sensory polyradiculopathy. ( 28668085 )
2017
3
Motor polyradiculopathy during pembrolizumab treatment of metastatic melanoma. ( 28439919 )
2017
4
Meningitis, polyradiculopathy, and optic nerve involvement in neurobrucellosis: A rare clinical presentation. ( 28879916 )
2017
5
Two cases of chronic immune sensorimotor polyradiculopathy: Expanding the spectrum of chronic immune polyradiculopathies. ( 27530499 )
2016
6
Impaired function of C-nociceptors in chronic inflammatory demyelinating polyradiculopathy indicated by electrically induced axon flare reflex. ( 27763966 )
2016
7
Polyradiculopathy secondary to severe hypertriglyceridemia. ( 25956495 )
2015
8
Polyradiculopathy and Gastroparesis due to Cytomegalovirus Infection in AIDS: A Case Report and Review of Literature. ( 26552851 )
2015
9
Diagnostic utility of somatosensory evoked potentials in chronic polyradiculopathy without electrodiagnostic signs of peripheral demyelination. ( 25908550 )
2015
10
Cytomegalovirus polyradiculopathy in three Japanese patients with AIDS. ( 25758080 )
2015
11
Leukemic Polyradiculopathy Due to Blastic Plasmacytoid Dendritic Cell Neoplasm. ( 26099022 )
2015
12
Lyme Disease -Induced Polyradiculopathy Mimicking Amyotrophic Lateral Sclerosis. ( 24397499 )
2014
13
Acute inflammatory demyelinating polyradiculopathy in Legionella pneumonia. ( 25043391 )
2014
14
Successful treatment of infliximab-associated immune-mediated sensory polyradiculopathy with intravenous immunoglobulin. ( 23906523 )
2013
15
Steroid-responsive polyradiculopathy in association with focal segmental glomerulosclerosis. ( 26069832 )
2013
16
Cervical polyradiculopathy caused by vertebral artery dissection. ( 23622284 )
2013
17
Cytomegalovirus polyradiculopathy of late onset in a young renal transplant recipient. ( 23803598 )
2013
18
Chronic immune sensory polyradiculopathy with cranial and peripheral nerve involvement. ( 22124665 )
2012
19
Intracranial hypertension with polyradiculopathy--early CSF diversion to optimize neurological recovery. ( 22448758 )
2012
20
Chronic inflammatory lumbosacral polyradiculopathy: a regional variant of CIDP. ( 22006701 )
2011
21
Truncal polyradiculopathy due to sarcoidosis. ( 19339022 )
2009
22
Successful treatment of cytomegalovirus polyradiculopathy in a 9-year-old child with congenital human immunodeficiency virus infection. ( 19182160 )
2009
23
Polyradiculopathy and herpes zoster. ( 19633742 )
2009
24
Facial and trigeminal neuropathies as the initial manifestation of chronic inflammatory demyelinating polyradiculopathy. ( 19494731 )
2009
25
Subacute inflammatory polyradiculopathy associated with SjAPgren's syndrome. ( 19367638 )
2009
26
Familial ALS with SOD1 mutation misdiagnosed with polyradiculopathy and myopathy. ( 19922143 )
2009
27
Polyradiculopathy due to methotrexate-induced ebv-associated lymphoproliferative disorder. ( 19001256 )
2008
28
Significant clinical improvement in radiation-induced lumbosacral polyradiculopathy by a treatment combining pentoxifylline, tocopherol, and clodronate (Pentoclo). ( 18804790 )
2008
29
Chronic sensorimotor polyradiculopathy with antibodies to P2: an electrophysiological and immunoproteomic analysis. ( 18508345 )
2008
30
Anterior lumbosacral polyradiculopathy after intrathecal administration of methotrexate. ( 17949753 )
2008
31
Cytomegalovirus polyradiculopathy: a rare neurological manifestation of acquired immunodeficiency syndrome. ( 19127057 )
2008
32
Paraneoplastic lumbosacral axonal polyradiculopathy preceding the diagnosis of nodular lymphocyte predominant Hodgkin lymphoma: a case report. ( 18720211 )
2008
33
Chronic inflammatory demyelinating polyradiculopathy: an atypical pediatric case complicated with phrenic nerve palsy. ( 17907525 )
2007
34
AJR teaching file: progressive polyradiculopathy. ( 16498140 )
2006
35
Acute toxic polyradiculopathy after exorbitant intracarotid substance abuse. ( 16619129 )
2006
36
Intracranial hypertension causing polyradiculopathy and late or absent F-waves. ( 17110754 )
2006
37
Intracranial germinoma presenting as polyradiculopathy due to widespread spinal dissemination. ( 16937013 )
2006
38
Cidofovir treatment of HIV-associated cytomegalovirus polyradiculopathy. ( 16470133 )
2006
39
Reinfection with Lyme borreliosis presenting as a painful polyradiculopathy: Bannwarth's, Beevor's and Borrelia. ( 17043300 )
2006
40
Diabetic thoracic polyradiculopathy. ( 15833693 )
2005
41
Early syphilis presenting as a painful polyradiculopathy in an HIV positive individual. ( 15800090 )
2005
42
Polyradiculopathy post-concomitant chemoradiation for carcinoma of the uterine cervix treated with pelvic and para-aortic fields. ( 16188304 )
2005
43
Chronic immune sensory polyradiculopathy: a possibly treatable sensory ataxia. ( 15534252 )
2004
44
Late cytomegalovirus polyradiculopathy following haploidentical CD34+-selected hematopoietic stem cell transplantation. ( 14716290 )
2004
45
Severe lumbosacral polyradiculopathy complicating epidural anaesthesia. ( 14586612 )
2003
46
Polyradiculopathy. A rare complication of neurobrucellosis. ( 23648986 )
2003
47
Post-irradiation polyradiculopathy mimics leptomeningeal tumor on MRI. ( 12771271 )
2003
48
Polyradiculopathy in a patient of systemic lupus erythematosus. ( 12839359 )
2003
49
Ethylene glycol intoxication: electrophysiological studies suggest a polyradiculopathy. ( 12473781 )
2002
50
Ventral polyradiculopathy with pediatric acute lymphocytic leukemia. ( 11754193 )
2002

Variations for Polyradiculopathy

Expression for Polyradiculopathy

Search GEO for disease gene expression data for Polyradiculopathy.

Pathways for Polyradiculopathy

Pathways related to Polyradiculopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.29 BMP2 NOTCH1

GO Terms for Polyradiculopathy

Biological processes related to Polyradiculopathy according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cell development GO:0048468 9.51 BMP2 HSF4
2 positive regulation of cell differentiation GO:0045597 9.49 BMP2 HSF4
3 positive regulation of epithelial to mesenchymal transition GO:0010718 9.48 BMP2 NOTCH1
4 epithelial to mesenchymal transition GO:0001837 9.46 BMP2 NOTCH1
5 renal water homeostasis GO:0003091 9.43 AKR1B1 AVPR2
6 telencephalon development GO:0021537 9.4 AVPR2 BMP2
7 positive regulation of JAK-STAT cascade GO:0046427 9.37 AKR1B1 NOTCH1
8 cardiac muscle tissue morphogenesis GO:0055008 9.32 BMP2 NOTCH1
9 endocardial cushion morphogenesis GO:0003203 9.26 BMP2 NOTCH1
10 cardiac epithelial to mesenchymal transition GO:0060317 9.16 BMP2 NOTCH1
11 positive regulation of astrocyte differentiation GO:0048711 8.96 BMP2 NOTCH1
12 atrioventricular valve morphogenesis GO:0003181 8.62 BMP2 NOTCH1

Sources for Polyradiculopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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