MCID: PLY021
MIFTS: 35

Polyradiculopathy

Categories: Neuronal diseases

Aliases & Classifications for Polyradiculopathy

MalaCards integrated aliases for Polyradiculopathy:

Name: Polyradiculopathy 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4307
MeSH 44 D011128
NCIt 50 C34934
SNOMED-CT 68 75572007
UMLS 73 C0032586

Summaries for Polyradiculopathy

MalaCards based summary : Polyradiculopathy is related to cauda equina syndrome and chronic polyradiculoneuritis. An important gene associated with Polyradiculopathy is AKR1B1 (Aldo-Keto Reductase Family 1 Member B), and among its related pathways/superpathways is Heart Development. The drugs Mycophenolic acid and Antitubercular Agents have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, cervix and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 Radiculopathy, also commonly referred to as pinched nerve, refers to a set of conditions in which one or... more...

Related Diseases for Polyradiculopathy

Diseases related to Polyradiculopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 cauda equina syndrome 11.6
2 chronic polyradiculoneuritis 11.1
3 ossification of the posterior longitudinal ligament of spine 10.1 AVPR2 BMP2
4 spondylolisthesis 10.1 BMP2 IVD
5 neuropathy 10.1
6 spinal cord disease 10.1 AVPR2 HSF4
7 leukemia 10.1
8 lymphoma 10.1
9 lymphocytic leukemia 10.1
10 spastic hemiplegia 10.0 CAPN15 HFM1
11 ischemic bone disease 10.0 ACAN BMP2
12 degenerative disc disease 10.0 ACAN BMP2
13 systemic lupus erythematosus 10.0
14 leukemia, acute lymphoblastic 10.0
15 siderosis 10.0
16 lyme disease 10.0
17 guillain-barre syndrome 10.0
18 polyneuropathy 10.0
19 pneumonia 10.0
20 acquired immunodeficiency syndrome 10.0
21 herpes zoster 10.0
22 lupus erythematosus 10.0
23 intracranial hypertension 10.0
24 meningitis 10.0
25 cytomegalovirus infection 10.0
26 superficial siderosis 10.0
27 bone deterioration disease 10.0 ACAN BMP2 IVD
28 bone structure disease 10.0 ACAN BMP2 IVD
29 keratopathy 9.9 AKR1B1 TAC1
30 epicondylitis 9.9 HFM1 TAC1
31 aortic valve disease 1 9.9 ACAN BMP2 NOTCH1
32 amyotrophic lateral sclerosis 1 9.8
33 lymphoma, hodgkin, classic 9.8
34 focal segmental glomerulosclerosis 1 9.8
35 acute lymphocytic leukemia 9.8
36 diabetes mellitus 9.8
37 focal segmental glomerulosclerosis 9.8
38 hematopoietic stem cell transplantation 9.8
39 spinal stenosis 9.8
40 amyotrophic neuralgia 9.8
41 st. louis encephalitis 9.8
42 gastroparesis 9.8
43 arachnoiditis 9.8
44 melanoma 9.8
45 lateral sclerosis 9.8
46 substance abuse 9.8
47 neurilemmomatosis 9.8
48 syphilis 9.8
49 myopathy 9.8
50 human immunodeficiency virus infectious disease 9.8

Graphical network of the top 20 diseases related to Polyradiculopathy:



Diseases related to Polyradiculopathy

Symptoms & Phenotypes for Polyradiculopathy

GenomeRNAi Phenotypes related to Polyradiculopathy according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.89 CAPN15
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.89 BMP2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.89 AKR1B1 BMP2 CAPN15 NOTCH1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.89 AKR1B1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.89 CAPN15
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.89 AKR1B1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.89 AKR1B1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.89 NOTCH1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.89 AKR1B1 BMP2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.89 CAPN15
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.89 NOTCH1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.89 NOTCH1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.89 AKR1B1
14 Increased transferrin (TF) endocytosis GR00363-A 9.32 ACAN AKR1B1 AVPR2 BMP2 CAPN15 CD6

Drugs & Therapeutics for Polyradiculopathy

Drugs for Polyradiculopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolic acid Approved Phase 3 24280-93-1 446541
2 Antitubercular Agents Phase 3
3 gamma-Globulins Phase 3
4 Immunoglobulins, Intravenous Phase 3
5 Immunoglobulins Phase 3
6 Antibiotics, Antitubercular Phase 3
7 Anti-Infective Agents Phase 3
8 Anti-Bacterial Agents Phase 3
9 Rho(D) Immune Globulin Phase 3
10 Antibodies Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Interest of Mycophenolate for CIDP Weaning Active, not recruiting NCT02494505 Phase 3 Mycophenolate Mofetil;placebo
2 Peristeen Bowel Irrigation System in Cauda Equina Completed NCT01784328 Not Applicable
3 BLB Study Back or Leg Pain and Bladder Symptoms Study Recruiting NCT03325374
4 Stereotactic Body Radiotherapy Boost After Palliative Radiotherapy for Spinal Cord Compression Not yet recruiting NCT03529708 Not Applicable
5 Post-void Bladder Scanning in Acute Cauda Equina Syndrome Withdrawn NCT02806167 Not Applicable

Search NIH Clinical Center for Polyradiculopathy

Genetic Tests for Polyradiculopathy

Anatomical Context for Polyradiculopathy

MalaCards organs/tissues related to Polyradiculopathy:

41
Spinal Cord, Cervix, Bone

Publications for Polyradiculopathy

Articles related to Polyradiculopathy:

(show top 50) (show all 122)
# Title Authors Year
1
Lumbosacral polyradiculopathy after intrathecal chemotherapy in pediatric acute lymphoblastic leukemia. ( 29470812 )
2018
2
Acute polyradiculopathy secondary to idelalisib in Relapsed Classical Hodgkin's lymphoma. ( 30191811 )
2018
3
Management of chronic inflammatory demyelinating polyradiculopathy. ( 30045075 )
2018
4
Diagnostic usefulness of plexus MRI in chronic inflammatory demyelinating polyradiculopathy without electrodiagnostic criteria of demyelination. ( 30431216 )
2018
5
Utility of somatosensory evoked potentials in the assessment of response to IVIG in a long-lasting case of chronic immune sensory polyradiculopathy. ( 28668085 )
2017
6
Motor polyradiculopathy during pembrolizumab treatment of metastatic melanoma. ( 28439919 )
2017
7
Meningitis, polyradiculopathy, and optic nerve involvement in neurobrucellosis: A rare clinical presentation. ( 28879916 )
2017
8
Two cases of chronic immune sensorimotor polyradiculopathy: Expanding the spectrum of chronic immune polyradiculopathies. ( 27530499 )
2016
9
Impaired function of C-nociceptors in chronic inflammatory demyelinating polyradiculopathy indicated by electrically induced axon flare reflex. ( 27763966 )
2016
10
Polyradiculopathy secondary to severe hypertriglyceridemia. ( 25956495 )
2015
11
Polyradiculopathy and Gastroparesis due to Cytomegalovirus Infection in AIDS: A Case Report and Review of Literature. ( 26552851 )
2015
12
Diagnostic utility of somatosensory evoked potentials in chronic polyradiculopathy without electrodiagnostic signs of peripheral demyelination. ( 25908550 )
2015
13
Cytomegalovirus polyradiculopathy in three Japanese patients with AIDS. ( 25758080 )
2015
14
Leukemic Polyradiculopathy Due to Blastic Plasmacytoid Dendritic Cell Neoplasm. ( 26099022 )
2015
15
Lyme Disease -Induced Polyradiculopathy Mimicking Amyotrophic Lateral Sclerosis. ( 24397499 )
2014
16
Acute inflammatory demyelinating polyradiculopathy in Legionella pneumonia. ( 25043391 )
2014
17
Successful treatment of infliximab-associated immune-mediated sensory polyradiculopathy with intravenous immunoglobulin. ( 23906523 )
2013
18
Steroid-responsive polyradiculopathy in association with focal segmental glomerulosclerosis. ( 26069832 )
2013
19
Cervical polyradiculopathy caused by vertebral artery dissection. ( 23622284 )
2013
20
Cytomegalovirus polyradiculopathy of late onset in a young renal transplant recipient. ( 23803598 )
2013
21
Chronic immune sensory polyradiculopathy with cranial and peripheral nerve involvement. ( 22124665 )
2012
22
Intracranial hypertension with polyradiculopathy--early CSF diversion to optimize neurological recovery. ( 22448758 )
2012
23
Chronic inflammatory lumbosacral polyradiculopathy: a regional variant of CIDP. ( 22006701 )
2011
24
Truncal polyradiculopathy due to sarcoidosis. ( 19339022 )
2009
25
Successful treatment of cytomegalovirus polyradiculopathy in a 9-year-old child with congenital human immunodeficiency virus infection. ( 19182160 )
2009
26
Polyradiculopathy and herpes zoster. ( 19633742 )
2009
27
Facial and trigeminal neuropathies as the initial manifestation of chronic inflammatory demyelinating polyradiculopathy. ( 19494731 )
2009
28
Subacute inflammatory polyradiculopathy associated with SjAPgren's syndrome. ( 19367638 )
2009
29
Familial ALS with SOD1 mutation misdiagnosed with polyradiculopathy and myopathy. ( 19922143 )
2009
30
Polyradiculopathy due to methotrexate-induced ebv-associated lymphoproliferative disorder. ( 19001256 )
2008
31
Significant clinical improvement in radiation-induced lumbosacral polyradiculopathy by a treatment combining pentoxifylline, tocopherol, and clodronate (Pentoclo). ( 18804790 )
2008
32
Chronic sensorimotor polyradiculopathy with antibodies to P2: an electrophysiological and immunoproteomic analysis. ( 18508345 )
2008
33
Anterior lumbosacral polyradiculopathy after intrathecal administration of methotrexate. ( 17949753 )
2008
34
Cytomegalovirus polyradiculopathy: a rare neurological manifestation of acquired immunodeficiency syndrome. ( 19127057 )
2008
35
Paraneoplastic lumbosacral axonal polyradiculopathy preceding the diagnosis of nodular lymphocyte predominant Hodgkin lymphoma: a case report. ( 18720211 )
2008
36
Chronic inflammatory demyelinating polyradiculopathy: an atypical pediatric case complicated with phrenic nerve palsy. ( 17907525 )
2007
37
AJR teaching file: progressive polyradiculopathy. ( 16498140 )
2006
38
Acute toxic polyradiculopathy after exorbitant intracarotid substance abuse. ( 16619129 )
2006
39
Intracranial hypertension causing polyradiculopathy and late or absent F-waves. ( 17110754 )
2006
40
Intracranial germinoma presenting as polyradiculopathy due to widespread spinal dissemination. ( 16937013 )
2006
41
Cidofovir treatment of HIV-associated cytomegalovirus polyradiculopathy. ( 16470133 )
2006
42
Reinfection with Lyme borreliosis presenting as a painful polyradiculopathy: Bannwarth's, Beevor's and Borrelia. ( 17043300 )
2006
43
Diabetic thoracic polyradiculopathy. ( 15833693 )
2005
44
Early syphilis presenting as a painful polyradiculopathy in an HIV positive individual. ( 15800090 )
2005
45
Polyradiculopathy post-concomitant chemoradiation for carcinoma of the uterine cervix treated with pelvic and para-aortic fields. ( 16188304 )
2005
46
Chronic immune sensory polyradiculopathy: a possibly treatable sensory ataxia. ( 15534252 )
2004
47
Late cytomegalovirus polyradiculopathy following haploidentical CD34+-selected hematopoietic stem cell transplantation. ( 14716290 )
2004
48
Severe lumbosacral polyradiculopathy complicating epidural anaesthesia. ( 14586612 )
2003
49
Polyradiculopathy. A rare complication of neurobrucellosis. ( 23648986 )
2003
50
Post-irradiation polyradiculopathy mimics leptomeningeal tumor on MRI. ( 12771271 )
2003

Variations for Polyradiculopathy

Expression for Polyradiculopathy

Search GEO for disease gene expression data for Polyradiculopathy.

Pathways for Polyradiculopathy

Pathways related to Polyradiculopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.29 BMP2 NOTCH1

GO Terms for Polyradiculopathy

Cellular components related to Polyradiculopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 ACAN BMP2 CD6 KLK8 NOTCH1 TAC1

Biological processes related to Polyradiculopathy according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.69 ACAN BMP2 NOTCH1
2 response to lipopolysaccharide GO:0032496 9.58 CD6 NOTCH1 TAC1
3 cell development GO:0048468 9.55 BMP2 HSF4
4 positive regulation of cell differentiation GO:0045597 9.54 BMP2 HSF4
5 positive regulation of epithelial to mesenchymal transition GO:0010718 9.52 BMP2 NOTCH1
6 epithelial to mesenchymal transition GO:0001837 9.49 BMP2 NOTCH1
7 renal water homeostasis GO:0003091 9.48 AKR1B1 AVPR2
8 telencephalon development GO:0021537 9.46 AVPR2 BMP2
9 positive regulation of JAK-STAT cascade GO:0046427 9.43 AKR1B1 NOTCH1
10 cardiac muscle tissue morphogenesis GO:0055008 9.37 BMP2 NOTCH1
11 endocardial cushion morphogenesis GO:0003203 9.32 BMP2 NOTCH1
12 positive regulation of ossification GO:0045778 9.26 BMP2 TAC1
13 cardiac epithelial to mesenchymal transition GO:0060317 9.16 BMP2 NOTCH1
14 atrioventricular valve morphogenesis GO:0003181 8.96 BMP2 NOTCH1
15 positive regulation of astrocyte differentiation GO:0048711 8.62 BMP2 NOTCH1

Sources for Polyradiculopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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