MCID: PLY021
MIFTS: 32

Polyradiculopathy

Categories: Bone diseases, Muscle diseases, Neuronal diseases

Aliases & Classifications for Polyradiculopathy

MalaCards integrated aliases for Polyradiculopathy:

Name: Polyradiculopathy 12 44 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4307
MeSH 44 D011128
NCIt 50 C34934
SNOMED-CT 67 75572007
UMLS 70 C0032586

Summaries for Polyradiculopathy

Disease Ontology : 12 A radiculopathy that is present in more than one nerve.

MalaCards based summary : Polyradiculopathy is related to guillain-barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy. An important gene associated with Polyradiculopathy is ICOSLG (Inducible T Cell Costimulator Ligand), and among its related pathways/superpathways is Cell adhesion molecules. The drugs Mycophenolic acid and Antibiotics, Antitubercular have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, myeloid and cervix.

Wikipedia : 73 Radiculopathy, also commonly referred to as pinched nerve, refers to a set of conditions in which one or... more...

Related Diseases for Polyradiculopathy

Diseases related to Polyradiculopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 193)
# Related Disease Score Top Affiliating Genes
1 guillain-barre syndrome 31.5 MBP DAAM2
2 chronic inflammatory demyelinating polyradiculoneuropathy 30.5 MBP ICOSLG
3 myelitis 30.1 MBP ICOSLG
4 demyelinating polyneuropathy 30.0 NFASC CNTN1
5 polyneuropathy 30.0 NFASC MBP CNTN1 AKR1B1
6 chickenpox 29.9 ICOSLG CD4
7 transverse myelitis 29.8 MBP ICOSLG
8 neuropathy 29.8 NFASC MBP GLDN AKR1B1
9 peripheral nervous system disease 29.5 NFASC MBP ICOSLG CD4 AKR1B1
10 exanthem 29.4 ICOSLG CD4
11 cauda equina syndrome 11.2
12 polyradiculoneuropathy 11.0
13 chronic polyradiculoneuritis 10.9
14 ataxia and polyneuropathy, adult-onset 10.3
15 american histoplasmosis 10.3 CD4 AKR1B1
16 ophthalmomyiasis 10.3 CD4 AKR1B1
17 autoimmune peripheral neuropathy 10.3 ICOSLG CD4
18 dacryoadenitis 10.3 ICOSLG CD4
19 immunodeficiency with hyper-igm, type 3 10.3 ICOSLG CD4
20 legume allergy 10.2 ICOSLG CD4
21 acquired immunodeficiency syndrome 10.2
22 fruit allergy 10.2 ICOSLG CD4
23 acute proliferative glomerulonephritis 10.2 ICOSLG CD4
24 immunodeficiency 16 10.2 ICOSLG CD4
25 chronic conjunctivitis 10.2 ICOSLG CD4
26 autoimmune glomerulonephritis 10.2 ICOSLG CD4
27 autoimmune disease of urogenital tract 10.2 ICOSLG CD4
28 immunodeficiency 13 10.2 ICOSLG CD4
29 childhood type dermatomyositis 10.2 ICOSLG CD4
30 autoimmune disease of eyes, ear, nose and throat 10.2 ICOSLG CD4
31 intestinal schistosomiasis 10.2 ICOSLG CD4
32 primary thrombocytopenia 10.2 ICOSLG CD4
33 klebsiella pneumonia 10.2 ICOSLG CD4
34 lichen disease 10.2 ICOSLG CD4
35 immune-complex glomerulonephritis 10.2 ICOSLG CD4
36 sialadenitis 10.2 ICOSLG CD4
37 hypersensitivity reaction type iii disease 10.2 ICOSLG CD4
38 immunoglobulin alpha deficiency 10.2 ICOSLG CD4
39 lacrimal apparatus disease 10.2 ICOSLG CD4
40 anemia, autoimmune hemolytic 10.2 ICOSLG CD4
41 thrombocytopenia due to platelet alloimmunization 10.2 ICOSLG CD4
42 autoimmune disease of blood 10.2 ICOSLG CD4
43 respiratory allergy 10.2 ICOSLG CD4
44 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.2 ICOSLG CD4
45 t cell deficiency 10.2 ICOSLG CD4
46 herpangina 10.2 ICOSLG CD4
47 conjunctival disease 10.2 ICOSLG CD4
48 panuveitis 10.2 ICOSLG CD4
49 listeriosis 10.2 ICOSLG CD4
50 autoimmune disease of exocrine system 10.2 ICOSLG CD4

Graphical network of the top 20 diseases related to Polyradiculopathy:



Diseases related to Polyradiculopathy

Symptoms & Phenotypes for Polyradiculopathy

Drugs & Therapeutics for Polyradiculopathy

Drugs for Polyradiculopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolic acid Approved Phase 3 24280-93-1 446541
2 Antibiotics, Antitubercular Phase 3
3 Immunoglobulins, Intravenous Phase 3
4 Immunoglobulins Phase 3
5 gamma-Globulins Phase 3
6 Antitubercular Agents Phase 3
7 Anti-Bacterial Agents Phase 3
8 Rho(D) Immune Globulin Phase 3
9 Antibodies Phase 3
10 Anti-Infective Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Does the Mycophenolate Improve the Ability of Weaning Patients Off the Treatment in Chronic Inflammatory Demyelinating Polyradiculopathy (CIDP) Completed NCT02494505 Phase 3 Mycophenolate Mofetil;placebo
2 A Study Into the Use of Post-Void Bladder Scanning as Part of a Clinical Algorithm for the Assessment of Patients With Suspected Acute Cauda Equina Syndrome Withdrawn NCT02806167

Search NIH Clinical Center for Polyradiculopathy

Cochrane evidence based reviews: polyradiculopathy

Genetic Tests for Polyradiculopathy

Anatomical Context for Polyradiculopathy

MalaCards organs/tissues related to Polyradiculopathy:

40
Spinal Cord, Myeloid, Cervix, Neutrophil

Publications for Polyradiculopathy

Articles related to Polyradiculopathy:

(show top 50) (show all 372)
# Title Authors PMID Year
1
Acute immune sensory polyradiculopathy: a new variant of Guillain-Barré syndrome. 61
33347623 2021
2
In the borderland of multifocal motor neuropathy and chronic inflammatory demyelinating polyradiculopathy. 61
33074453 2021
3
CISP-Plus: Expanding the Spectrum of Chronic Immune Sensory Polyradiculopathy (CISP). 61
33653905 2021
4
Juvenile Chronic Inflammatory Demyelinating Polyneuropathy Epidemiology in Sardinia, Insular Italy. 61
33111308 2021
5
Leucine Zipper 4 Autoantibody: A Novel Germ Cell Tumor and Paraneoplastic Biomarker. 61
33583072 2021
6
Chronic inflammatory demyelinating polyradiculoneuropathy: can a diagnosis be made in patients not fulfilling electrodiagnostic criteria? 61
32959475 2021
7
Lumbosacral polyradiculitis associated with brucellosis. 61
33384926 2021
8
Evaluation of clinical, diagnostic features and therapeutic outcome of neurobrucellosis: a case series and review of literature. 61
33287603 2021
9
Chronic immune sensory polyradiculopathy (CISP): First juvenile case description. 61
32651857 2021
10
Guillain-Barre Syndrome Amid Osteosarcoma Treatment: A Therapeutic Dilemma and Literature Review. 61
33542879 2021
11
Chronic immune polyradiculopathies: Three clinical variants of one disease? 61
32710692 2021
12
Polyradiculopathy and Multiple Cranial Nerve Palsies - Rare Manifestations of Cerebral Venous Sinus Thrombosis. 61
33642294 2021
13
Optimizing Investigations for Evaluation of Enlargements of the Roots, Plexuses and Nerves: A Study of 133 Patients. 61
33623269 2020
14
Camidanlumab tesirine, an antibody-drug conjugate, in relapsed/refractory CD25-positive acute myeloid leukemia or acute lymphoblastic leukemia: A phase I study. 61
32521310 2020
15
Contactin-1 autoimmunity: Serologic, neurologic, and pathologic correlates. 61
32461352 2020
16
High-Pressure Normocephalus-Raised Intracranial Pressure with False Localizing Signs. 61
33223673 2020
17
Neurologic complications of immune checkpoint inhibitors. 61
32126176 2020
18
An Atypical and Multifactorial Acute Immune Polyradiculopathy: A Case Report. 61
32373275 2020
19
Cauda Equina Syndrome Secondary to Diffuse Infiltration of the Cauda Equina by Acute Myeloid Leukemia: Case Report and Literature Review. 61
31759146 2020
20
Early Aggressive Immunotherapy Improves Functional Outcome in Chronic Immune Sensory Polyradiculopathy. 61
32148984 2020
21
Pneumococcal Meningitis Complicated by Spinal Cord Dysfunction and Acute Polyradiculopathy. 61
32612480 2020
22
Expanded neuromuscular morbidity in Hodgkin lymphoma after radiotherapy. 61
32954302 2020
23
Brucellosis causing subacute motor polyradiculopathy and the pathological correlation of pseudomyopathic electromyography: A case report. 61
32642603 2020
24
Integrated Chinese and Western Medicine for Acute Guillain-barré Syndrome Treatment. 61
32161685 2020
25
Meningoradiculitis and transaminitis from neuroborreliosis: A case of variant Bannwarth syndrome. 61
31574359 2019
26
Embolized Spinal Dural AV Fistula Repairs Syringomyelia and Polyradiculopathy. 61
31486386 2019
27
Neurotoxicity associated with cancer immunotherapy: immune checkpoint inhibitors and chimeric antigen receptor T-cell therapy. 61
30893101 2019
28
Bilateral pan-plexus lesion after substance use: A case report. 61
31893280 2019
29
Chronic immune sensorimotor polyradiculopathy: Report of a case series. 61
30697760 2019
30
Autonomic involvement in Guillain-Barré syndrome: an update. 61
30019292 2019
31
Role of Anti-ganglioside Antibodies in the Diagnosis of Guillain-Barré Syndrome as an Alternate Investigation. 61
31312551 2019
32
Guillain Barre syndrome with pulmonary tuberculosis: A case series from a tertiary care hospital. 61
31198762 2019
33
Diagnostic usefulness of plexus magnetic resonance imaging in chronic inflammatory demyelinating polyradiculopathy without electrodiagnostic criteria of demyelination. 61
30431216 2019
34
Leptospirosis complicated with Guillain Barre syndrome, papillitis and thrombotic thrombocytopenic Purpura; a case report. 61
30577755 2018
35
Foot drop post varicella zoster virus. 61
30567099 2018
36
Mononeuritis multiplex: an uncommon neurological manifestation of cytomegalovirus reactivation in an HIV-infected patient. 61
30419847 2018
37
Management of chronic inflammatory demyelinating polyradiculopathy. 61
30045075 2018
38
Acute polyradiculopathy secondary to idelalisib in Relapsed Classical Hodgkin's lymphoma. 61
30191811 2018
39
Posterior Epidural Migration of a Lumbar Intervertebral Disc Fragment Resembling a Spinal Tumor: A Case Report. 61
30180533 2018
40
Increased intracranial pressure in Guillain-Barré syndrome: A case report. 61
30045288 2018
41
A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection. 61
29985307 2018
42
Lumbosacral polyradiculopathy after intrathecal chemotherapy in pediatric acute lymphoblastic leukemia. 61
29470812 2018
43
Severe Acute Axonal Neuropathy Induced by Ciprofloxacin: A Case Report. 61
29928218 2018
44
Disorders of the Cauda Equina. 61
29613901 2018
45
Acute demyelinating neuropathy in a patient with neurolymphomatosis. 61
29507018 2018
46
Autoimmune/inflammatory syndrome induced by adjuvants-ASIA-related to biomaterials: analysis of 45 cases and comprehensive review of the literature. 61
29199390 2018
47
Fibromyalgia and unexplained widespread pain: The idiopathic cerebrospinal pressure dysregulation hypothesis. 61
29317060 2018
48
Epidemiology and Clinical Features of Guillain-Barre Syndrome in Isfahan, Iran. 61
29930927 2018
49
Motor polyradiculopathy during pembrolizumab treatment of metastatic melanoma. 61
28439919 2017
50
Meningitis, polyradiculopathy, and optic nerve involvement in neurobrucellosis: A rare clinical presentation. 61
28879916 2017

Variations for Polyradiculopathy

Expression for Polyradiculopathy

Search GEO for disease gene expression data for Polyradiculopathy.

Pathways for Polyradiculopathy

Pathways related to Polyradiculopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.1 NFASC ICOSLG CNTN1 CD4

GO Terms for Polyradiculopathy

Cellular components related to Polyradiculopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 paranodal junction GO:0033010 8.96 NFASC AKR1B1
2 Schwann cell microvillus GO:0097454 8.62 NFASC AKR1B1

Biological processes related to Polyradiculopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myelination GO:0042552 9.16 NFASC MBP
2 T cell activation GO:0042110 8.96 ICOSLG CD4
3 heterotypic cell-cell adhesion GO:0034113 8.62 NFASC GLDN

Sources for Polyradiculopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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