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MCID: PLY068
MIFTS: 35

Polysubstance Abuse

Categories: Genetic diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Polysubstance Abuse

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MalaCards integrated aliases for Polysubstance Abuse:

Name: Polysubstance Abuse 57 55 73
Polysubstance Abuse, Susceptibility to 57 29 6 40
Drug Addiction, Susceptibility to 57 13
Drug Addiction 57 55
Drug Dependence 73
Psab 57

Classifications:

MalaCards categories:
Global: Genetic diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM 57 606581
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Summaries for Polysubstance Abuse

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MalaCards based summary : Polysubstance Abuse, also known as polysubstance abuse, susceptibility to, is related to substance dependence and hallucinogen dependence. An important gene associated with Polysubstance Abuse is FAAH (Fatty Acid Amide Hydrolase), and among its related pathways/superpathways are Circadian entrainment and Monoamine GPCRs. The drug Cocaine has been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotypes are behavior/neurological and homeostasis/metabolism

Description from OMIM: 606581
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Related Diseases for Polysubstance Abuse

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Diseases related to Polysubstance Abuse via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 substance dependence 30.9 CNR1 DRD2 DRD3
2 hallucinogen dependence 10.3 CNR1 FAAH
3 autoimmune encephalitis 10.2 CNR1 FAAH
4 delusional disorder 10.0 DRD2 DRD3
5 impulse control disorder 10.0 DRD2 DRD3
6 pathological gambling 10.0 DRD2 DRD3
7 drug-induced mental disorder 10.0 CNR1 DRD2
8 drug psychosis 10.0 CNR1 DRD2
9 migraine without aura 9.9 DRD2 DRD3
10 opiate dependence 9.9 DRD2 DRD3
11 acute leukemia 9.9
12 hepatitis 9.9
13 leukemia 9.9
14 subdural empyema 9.9
15 mononeuritis multiplex 9.9
16 hepatitis c 9.9
17 bacterial meningitis 9.9
18 meningitis 9.9
19 cocaine dependence 9.9 DRD2 DRD3
20 chronic pain 9.8 CNR1 COMT
21 movement disease 9.8 DRD2 DRD3
22 somatoform disorder 9.7 COMT FAAH
23 schizophreniform disorder 9.7 COMT DRD2
24 oppositional defiant disorder 9.6 COMT DRD2
25 alexithymia 9.6 COMT DRD2
26 opioid addiction 9.6 COMT DRD2
27 traumatic brain injury 9.6 COMT DRD2
28 antisocial personality disorder 9.6 COMT DRD2
29 brain injury 9.6 COMT DRD2
30 conduct disorder 9.5 COMT DRD2
31 specific developmental disorder 9.5 CNR1 COMT
32 drug dependence 9.5 CNR1 DRD2 DRD3
33 restless legs syndrome 9.5 DRD2 DRD3
34 cannabis dependence 9.3 CNR1 COMT FAAH
35 tobacco addiction 9.3 COMT DRD2
36 body mass index quantitative trait locus 11 9.3 CNR1 DRD2 FAAH
37 gilles de la tourette syndrome 9.2 COMT DRD2
38 tardive dyskinesia 9.1 COMT DRD2 DRD3
39 early-onset schizophrenia 9.1 COMT DRD2 DRD3
40 personality disorder 9.1 COMT DRD2 DRD3
41 substance abuse 9.1 COMT DRD2 DRD3
42 eating disorder 9.1 CNR1 COMT DRD2
43 schizoaffective disorder 9.1 COMT DRD2 DRD3
44 mood disorder 9.1 COMT DRD2 DRD3
45 obsessive-compulsive disorder 9.1 COMT DRD2 DRD3
46 major depressive disorder 9.1 COMT DRD2 DRD3
47 attention deficit-hyperactivity disorder 9.0 COMT DRD2 DRD3
48 anxiety 9.0 CNR1 COMT
49 alcohol abuse 9.0 CNR1 DRD2 DRD3 FAAH
50 bipolar disorder 8.9 COMT DRD2 DRD3

Graphical network of the top 20 diseases related to Polysubstance Abuse:



Diseases related to Polysubstance Abuse
Sources

Symptoms & Phenotypes for Polysubstance Abuse

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Clinical features from OMIM:

606581

MGI Mouse Phenotypes related to Polysubstance Abuse:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.55 CNR1 COMT DRD2 DRD3 FAAH
2 homeostasis/metabolism MP:0005376 9.35 CNR1 COMT DRD2 DRD3 FAAH
3 nervous system MP:0003631 9.02 CNR1 COMT DRD2 DRD3 FAAH
Sources

Drugs & Therapeutics for Polysubstance Abuse

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Drugs for Polysubstance Abuse (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cocaine Approved, Illicit Phase 2 50-36-2 5760 446220

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Abstinence-Linked Money Management Multisite Completed NCT01327586 Phase 2

Search NIH Clinical Center for Polysubstance Abuse

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Genetic Tests for Polysubstance Abuse

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Genetic tests related to Polysubstance Abuse:

# Genetic test Affiliating Genes
1 Polysubstance Abuse, Susceptibility to 29 FAAH
Sources

Anatomical Context for Polysubstance Abuse

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MalaCards organs/tissues related to Polysubstance Abuse:

41
Liver
Sources

Publications for Polysubstance Abuse

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Articles related to Polysubstance Abuse:

(show all 21)
# Title Authors Year
1
Prevalence of Polysubstance Abuse and Dual Diagnosis in Patients Admitted to Alcohol Rehabilitation Units for Alcohol-Related Problems in Italy: Changes in 15 Years. ( 29016981 )
2017
2
Active Polysubstance Abuse Concurrent With Surgery as a Possible Newly Identified Infection Risk Factor in Inflatable Penile Prosthesis Placement Based on a Retrospective Analysis of Health and Socioeconomic Factors. ( 26928774 )
2016
3
Critical needs in drug discovery for cessation of alcohol and nicotine polysubstance abuse. ( 26582145 )
2016
4
Subdural Empyema Complicating Bacterial Meningitis: A Challenging Diagnosis in a Patient with Polysubstance Abuse. ( 26543484 )
2015
5
Polysubstance abuse: alcohol, opioids and benzodiazepines require coordinated engagement by society, patients, and physicians. ( 25671013 )
2015
6
Bedside Nurse-Driven Protocol for Management of Alcohol/Polysubstance Abuse Withdrawal. ( 26628550 )
2015
7
Anabolic androgenic steroids and violent offending: confounding by polysubstance abuse among 10,365 general population men. ( 25170826 )
2015
8
Polysubstance abuse related subacute urinary retention and Hutch diverticulum of urinary bladder. ( 24765281 )
2011
9
A case of catatonia secondary to polysubstance abuse and acetaminophen overdose. ( 20582301 )
2010
10
A case of suspected mononeuritis multiplex in a teenager from polysubstance abuse. ( 19769924 )
2009
11
Acculturation and polysubstance abuse in Arab-American treatment clients. ( 20028679 )
2009
12
Infection following treatment of mandible fractures: the role of immunosuppression and polysubstance abuse. ( 17178492 )
2007
13
Polysubstance abuse in liver transplant patients and its impact on survival outcome. ( 18194121 )
2007
14
A 30-year-old man with a history of polysubstance abuse and hepatitis C presents with exertional dyspnea and patchy ground-glass opacities. ( 17099044 )
2006
15
Increased blasts mimicking acute leukemia in a patient with polysubstance abuse. ( 15679445 )
2005
16
The predictive validity of the university of rhode island change assessment questionnaire in a heroin-addicted polysubstance abuse sample. ( 15238052 )
2004
17
Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse. ( 15289816 )
2004
18
Treatment of polysubstance abuse in the active user. ( 14996244 )
2004
19
Delayed neuroexcitatory symptoms following propofol sedation in a patient with polysubstance abuse. ( 14507571 )
2003
20
Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms. ( 11704927 )
2001
21
D2 dopamine receptor gene TaqI A1 and B1 restriction fragment length polymorphisms: enhanced frequencies in psychostimulant-preferring polysubstance abusers. ( 8894071 )
1996
Sources

Variations for Polysubstance Abuse

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ClinVar genetic disease variations for Polysubstance Abuse:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 FAAH NM_001441.2(FAAH): c.385C> A (p.Pro129Thr) single nucleotide variant risk factor rs324420 GRCh37 Chromosome 1, 46870761: 46870761
2 FAAH NM_001441.2(FAAH): c.385C> A (p.Pro129Thr) single nucleotide variant risk factor rs324420 GRCh38 Chromosome 1, 46405089: 46405089
Sources

Expression for Polysubstance Abuse

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Search GEO for disease gene expression data for Polysubstance Abuse.
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Pathways for Polysubstance Abuse

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Pathways related to Polysubstance Abuse according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Circadian entrainment 37
Show member pathways
 12.41 COMT DRD2 DRD3
2
Monoamine GPCRs 1
Show member pathways
 11.38 DRD2 DRD3
3
GPCRs, Other 1
11.27 CNR1 DRD3
4
Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics 61
Show member pathways
 11.16 DRD2 DRD3
5
Ibuprofen Pathway, Pharmacodynamics 61
10.4 CNR1 FAAH
6
DARPP-32 Phosphorylation 65
9.97 DRD2 DRD3
Sources

GO Terms for Polysubstance Abuse

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Cellular components related to Polysubstance Abuse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytic vesicle GO:0030139 8.96 DRD2 DRD3
2 axon GO:0030424 8.8 CNR1 COMT DRD2

Biological processes related to Polysubstance Abuse according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.79 COMT DRD2 DRD3
2 response to ethanol GO:0045471 9.67 CNR1 DRD2 DRD3
3 regulation of lipid metabolic process GO:0019216 9.66 CNR1 DRD3
4 locomotory behavior GO:0007626 9.66 DRD2 DRD3
5 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007188 9.65 CNR1 DRD2
6 learning GO:0007612 9.65 COMT DRD3
7 negative regulation of protein kinase B signaling GO:0051898 9.65 DRD2 DRD3
8 learning or memory GO:0007611 9.64 CNR1 DRD3
9 circadian regulation of gene expression GO:0032922 9.64 DRD2 DRD3
10 visual learning GO:0008542 9.63 DRD2 DRD3
11 response to nicotine GO:0035094 9.63 CNR1 DRD2
12 positive regulation of cytokinesis GO:0032467 9.62 DRD2 DRD3
13 response to amphetamine GO:0001975 9.61 DRD2 DRD3
14 arachidonic acid secretion GO:0050482 9.61 DRD2 DRD3
15 behavioral response to cocaine GO:0048148 9.6 DRD2 DRD3
16 regulation of dopamine secretion GO:0014059 9.59 DRD2 DRD3
17 dopamine receptor signaling pathway GO:0007212 9.58 DRD2 DRD3
18 synaptic transmission, dopaminergic GO:0001963 9.58 DRD2 DRD3
19 negative regulation of protein secretion GO:0050709 9.57 DRD2 DRD3
20 positive regulation of renal sodium excretion GO:0035815 9.56 DRD2 DRD3
21 regulation of synaptic transmission, GABAergic GO:0032228 9.55 CNR1 DRD2
22 prepulse inhibition GO:0060134 9.54 DRD2 DRD3
23 G-protein coupled receptor internalization GO:0002031 9.52 DRD2 DRD3
24 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.51 DRD2 DRD3
25 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.48 DRD2 DRD3
26 acid secretion GO:0046717 9.46 DRD2 DRD3
27 negative regulation of dopamine secretion GO:0033602 9.43 CNR1 DRD2
28 response to cocaine GO:0042220 9.43 CNR1 DRD2 DRD3
29 negative regulation of dopamine receptor signaling pathway GO:0060160 9.4 DRD2 DRD3
30 response to histamine GO:0034776 9.37 DRD2 DRD3
31 response to morphine GO:0043278 9.33 CNR1 DRD2 DRD3
32 regulation of locomotion involved in locomotory behavior GO:0090325 9.32 DRD2 DRD3
33 negative regulation of blood pressure GO:0045776 9.13 CNR1 DRD2 DRD3
34 dopamine metabolic process GO:0042417 8.8 COMT DRD2 DRD3

Molecular functions related to Polysubstance Abuse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 obsolete signal transducer activity GO:0004871 9.5 CNR1 DRD2 DRD3
2 dopamine binding GO:0035240 9.26 DRD2 DRD3
3 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.16 DRD2 DRD3
4 dopamine neurotransmitter receptor activity GO:0004952 8.96 DRD2 DRD3
5 drug binding GO:0008144 8.8 CNR1 DRD2 DRD3
Sources

Sources for Polysubstance Abuse

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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