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MCID: PMP010
MIFTS: 37

Pompholyx

Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Pompholyx

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MalaCards integrated aliases for Pompholyx:

Name: Pompholyx 12 15
Vesicular Eczema of Hands and/or Feet 12 71
Dyshidrosis 12 17
Vesicular Hand Eczema 71
Eczema, Dyshidrotic 43
Dyshydrotic Eczema 12
Cheiropompholyx 12

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:9230
ICD9CM 34 705.81
MeSH 43 D011146
SNOMED-CT 67 25560004
ICD10 32 L30.1
UMLS 71 C0032633 C1535513
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Summaries for Pompholyx

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Disease Ontology : 12 A sweat gland disease that is characterized by recurrent vesicles and bullae that develop particularly upon the lateral palms, soles, and fingers and has symptom pruritis and cracked skin.

MalaCards based summary : Pompholyx, also known as vesicular eczema of hands and/or feet, is related to incontinentia pigmenti and anhidrosis, and has symptoms including pruritis and pustular rash. An important gene associated with Pompholyx is AQP10 (Aquaporin 10), and among its related pathways/superpathways are NF-kappa B signaling pathway and TNFs bind their physiological receptors. The drugs Alitretinoin and Isotretinoin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related phenotype is Decreased interferon-beta reporter expression.

Wikipedia : 74 Dyshidrosis, is a type of dermatitis, that is characterized by itchy blisters on the palms of the hands... more...

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Related Diseases for Pompholyx

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Diseases related to Pompholyx via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 incontinentia pigmenti 29.8 EDAR EDA
2 anhidrosis 29.0 GLA EDARADD EDAR EDA
3 ectodermal dysplasia 28.5 NECTIN1 GJB6 EDARADD EDAR EDA
4 palmoplantar carcinoma, multiple self-healing 11.3
5 dermatitis 10.7
6 contact dermatitis 10.3
7 bullous pemphigoid 10.3
8 skin disease 10.2
9 fabry disease 10.2
10 ige responsiveness, atopic 10.2
11 pemphigus vulgaris, familial 10.2
12 dermatitis, atopic 10.2
13 metal allergy 10.2
14 allergic hypersensitivity disease 10.2
15 pemphigus 10.2
16 48,xyyy 10.2
17 impaired renal function disease 10.0 AQP3 AQP10
18 syringomyelia, noncommunicating isolated 10.0
19 mycosis fungoides 10.0
20 insensitivity to pain, congenital, with anhidrosis 10.0
21 peeling skin syndrome 2 10.0
22 pain sensitivity quantitative trait locus 1 10.0
23 peripheral t-cell lymphoma 10.0
24 peeling skin syndrome 10.0
25 amenorrhea 10.0
26 candidiasis 10.0
27 epidermolysis bullosa 10.0
28 syringomyelia 10.0
29 purpura 10.0
30 spongiotic dermatitis 10.0
31 epidermolysis bullosa simplex 10.0
32 herpes zoster 10.0
33 neuropathy 10.0
34 diabetes mellitus 10.0
35 diabetic neuropathy 10.0
36 chiari malformation 10.0
37 nevus of ota 10.0
38 amyotrophic lateral sclerosis 1 10.0
39 polykaryocytosis inducer 10.0
40 pseudoxanthoma elasticum 10.0
41 pemphigus gestationis 10.0
42 exanthem 10.0
43 adult t-cell leukemia 10.0
44 lymphoma 10.0
45 neutropenia 10.0
46 leukemia 10.0
47 tinea pedis 10.0
48 pancytopenia 10.0
49 guillain-barre syndrome 10.0
50 pemphigoid gestationis 10.0

Graphical network of the top 20 diseases related to Pompholyx:



Diseases related to Pompholyx
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Symptoms & Phenotypes for Pompholyx

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Symptoms:

12
  • • pruritis

UMLS symptoms related to Pompholyx:


pustular rash

GenomeRNAi Phenotypes related to Pompholyx according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased interferon-beta reporter expression GR00307-A 8.8 AQP3 GLA SPINK6
Sources

Drugs & Therapeutics for Pompholyx

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Drugs for Pompholyx (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alitretinoin Approved, Investigational Phase 3 5300-03-8 444795 449171
2
Isotretinoin Approved Phase 3 4759-48-2 5538 5282379
3
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
4
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
5
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
6
Betamethasone Approved, Vet_approved Phase 3 378-44-9 9782
7
Ketoconazole Approved, Investigational Phase 3 65277-42-1 47576
8
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
9
Tretinoin Approved, Investigational, Nutraceutical Phase 3 302-79-4 5538 444795
10 Dermatologic Agents Phase 3
11 Anti-Infective Agents Phase 3
12 Cyclosporins Phase 3
13 Antifungal Agents Phase 3
14 Immunosuppressive Agents Phase 3
15 Antirheumatic Agents Phase 3
16 Immunologic Factors Phase 3
17 Calcineurin Inhibitors Phase 3
18 Gastrointestinal Agents Phase 3
19 Antiemetics Phase 3
20 Cytochrome P-450 CYP3A Inhibitors Phase 3
21 HIV Protease Inhibitors Phase 3
22 Anti-Asthmatic Agents Phase 3
23
protease inhibitors Phase 3
24 Cytochrome P-450 Enzyme Inhibitors Phase 3
25 Anti-Inflammatory Agents Phase 3
26 Respiratory System Agents Phase 3
27 Hormone Antagonists Phase 3
28 Betamethasone benzoate Phase 3
29 Autonomic Agents Phase 3
30 BB 1101 Phase 3
31 Betamethasone Valerate Phase 3 2152-44-5
32 Betamethasone sodium phosphate Phase 3
33 Anti-Infective Agents, Local Phase 3
34 Steroid Synthesis Inhibitors Phase 3
35 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
36 Antineoplastic Agents, Hormonal Phase 3
37 glucocorticoids Phase 3
38 Hormones Phase 3
39 Betamethasone-17,21-dipropionate Phase 3
40 Dandelion

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Alitretinoin in the Treatment of Severe Chronic Hand Eczema Refractory to Topical Therapy Completed NCT00817063 Phase 3 alitretinoin;Placebo
2 Efficacy of Oral Alitretinoin Versus Oral Cyclosporine in Patients With Severe Recurrent Vesicular Hand Eczema. A Randomized Prospective Open-label Trial With Blinded Outcome Assessment Recruiting NCT03026946 Phase 3 Alitretinoin;cyclosporin A
3 Phase 3 Study, Randomized, Double-blind, Parallel to Evaluate Ketoconazole and Betamethasone Dipropionate(Candicort®) Compared to Clotrimazole and Dexamethasone Acetate(Baycuten N®) in Relief of Fungal Infections/Dermatophytosis Symptoms. Recruiting NCT02582177 Phase 3 Candicort®;Nizoral®;Baycuten N®;Canesten®
4 Dandelion Juice in the Treatment of Dyshidrotic Hand Eczema Recruiting NCT00442091 dandelion juice

Search NIH Clinical Center for Pompholyx

Cochrane evidence based reviews: eczema, dyshidrotic

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Genetic Tests for Pompholyx

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Anatomical Context for Pompholyx

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MalaCards organs/tissues related to Pompholyx:

40
Skin, T Cells, Testes
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Publications for Pompholyx

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Articles related to Pompholyx:

(show top 50) (show all 156)
# Title Authors PMID Year
1
Pompholyx vesicles contain small clusters of cells with high levels of hyaluronate resembling the pustulovesicles of palmoplantar pustulosis. 61
31254390 2019
2
Pompholyx-Like Eruptions Induced by Penicillamine in a Patient with Wilson's Disease. 61
31516144 2019
3
Diagnostic histopathological features distinguishing palmoplantar pustulosis from pompholyx. 61
30919463 2019
4
Botulinum toxin (Botox) A for reducing the appearance of facial wrinkles: a literature review of clinical use and pharmacological aspect. 61
31114283 2019
5
A Case of Tinea Pedis in a Child Caused by Trichophyton interdigitale with Two Different Colony Phenotypes on Primary Culture. 61
31787732 2019
6
The microbiome of the "sterile" pustules in palmoplantar pustulosis. 61
30281856 2018
7
Non-cosmetic dermatological uses of botulinum neurotoxin. 61
27421250 2016
8
Patch Test as a Diagnostic Tool in Hand Eczema. 61
28050486 2016
9
Photoaggravated pompholyx. 61
26868937 2016
10
Pompholyx as a clinical manifestation suggesting increased serum IgG levels in a patient with drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. 61
26412450 2016
11
Pompholyx-like skin manifestation of adult T-cell leukemia/lymphoma. 61
26474722 2016
12
Dyshidrotic Eczema and Its Relationship to Metal Allergy. 61
27584966 2016
13
A Severe Case of Recalcitrant Pompholyx. 61
25876642 2015
14
Eccrine Chromhidrosis Resembling Clinical Features of Pompholyx with Bile-Like Greenish Pigmentation on the Right Palm and Soles. 61
26273179 2015
15
Single-Port Microthoracoscopic Sympathicotomy for the Treatment of Primary Palmar Hyperhidrosis: an Analysis of 56 Consecutive Cases. 61
26702233 2015
16
The key role of aquaporin 3 and aquaporin 10 in the pathogenesis of pompholyx. 61
25725905 2015
17
Pompholyx-like manifestation in Churg-Strauss syndrome. 61
25547649 2015
18
Unusual presentation of severe pompholyx. 61
25506565 2014
19
Dyshidrosiform presentation (pompholyx-like) of pemphigoid gestationis with intrauterine fetal death. 61
23432199 2014
20
Clinical and contact allergological observations on hand eczema: a descriptive study. 61
25799809 2014
21
Eczema and dermatitis in the afloat population: an overview of the assessment and management of the common erythematous skin conditions encountered in adults deployed on afloat platforms. 61
25895402 2014
22
Pompholyx of the hands after intravenous immunoglobulin therapy for clinically isolated syndrome: a paediatric case. 61
24674688 2014
23
A comparison of inflammatory mediator expression between palmoplantar pustulosis and pompholyx. 61
23802874 2013
24
Utility of epithelial membrane antigen immunostaining in the differentiation between palmoplantar pustulosis and pompholyx. 61
22988903 2013
25
Histological differentiation between palmoplantar pustulosis and pompholyx. 61
22691103 2013
26
Vesicular palmoplantar pityriasis rosea. 61
22545332 2012
27
Hand eczema: correlation of morphologic patterns, atopy, contact sensitization and disease severity. 61
22421645 2012
28
Pompholyx and eczematous reactions associated with intravenous immunoglobulin therapy. 61
21601310 2012
29
Detection of a novel single nucleotide polymorphism of the human thiopurine s-methyltransferase gene in a Chinese individual. 61
22447118 2012
30
Vesico-bullous rash caused by pompholyx eczema. 61
22665876 2012
31
Thoracoscopic Sympathicotomy vs Sympathectomy in Primary Hyperhidrosis. 61
24350109 2012
32
[Pompholyx-like reactions occurring early in treatment of severe atopic dermatitis in children and adolescence]. 61
22270129 2011
33
Topical and systemic therapies for nickel allergy. 61
22652902 2011
34
Seasonal variations in zooplankton abundances in the Iturbide reservoir (Isidro Fabela, State of Mexico, Mexico). 61
22315826 2011
35
[A case of dyshidrosiform pemphigoid]. 61
21702123 2011
36
Unilateral palm pompholyx in a patient with amyotrophic lateral sclerosis. 61
21561836 2011
37
Case study 4--A 35-year old male handyman with pompholyx blisters. 61
21309814 2011
38
[Monthly low-dose immunoglobulin infusion as a maintenance therapy for multifocal motor neuropathy may reduce allergic adverse effects: a case report]. 61
20803965 2010
39
Pemphigus vulgaris of the pompholyx type. 61
20403799 2010
40
Hand dermatitis/eczema: current management strategy. 61
20629825 2010
41
A case of palmar lichen nitidus presenting as a clinical feature of pompholyx. 61
20548925 2010
42
Pompholyx with bile-coloured vesicles in a patient with jaundice: are sweat ducts involved in the development of pompholyx? 61
19686259 2010
43
Pompholyx: a review of clinical features, differential diagnosis, and management. 61
20642293 2010
44
Dyshidrotic eczema: relevance to the immune response in situ. 61
22666682 2009
45
Hand dermatitis and lymphoedema. 61
19298277 2009
46
Acute and recurrent vesicular hand dermatitis. 61
19580928 2009
47
Pompholyx after intravenous immunoglobulin therapy for treatment of Guillain-Barré syndrome. 61
18761548 2009
48
[A new case of systemic contact eczema to nickel in a peripheral venous catheter]. 61
19061658 2008
49
Hand eczema: diagnosis and management. 61
19202671 2008
50
Patterns of lower leg and foot eczema in South India. 61
19052403 2008
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Variations for Pompholyx

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Expression for Pompholyx

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Search GEO for disease gene expression data for Pompholyx.
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Pathways for Pompholyx

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Pathways related to Pompholyx according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
NF-kappa B signaling pathway 36
11.14 EDARADD EDAR EDA
2
TNFs bind their physiological receptors 65
10.28 EDARADD EDAR EDA
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GO Terms for Pompholyx

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Biological processes related to Pompholyx according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.43 EDAR EDA
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.43 EDARADD EDAR EDA
3 odontogenesis of dentin-containing tooth GO:0042475 9.4 EDAR EDA
4 pigmentation GO:0043473 9.37 EDAR EDA
5 water transport GO:0006833 9.32 AQP3 AQP10
6 urea transmembrane transport GO:0071918 9.16 AQP3 AQP10
7 glycerol transport GO:0015793 8.96 AQP3 AQP10
8 salivary gland cavitation GO:0060662 8.62 EDAR EDA

Molecular functions related to Pompholyx according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 channel activity GO:0015267 9.26 AQP3 AQP10
2 water channel activity GO:0015250 9.16 AQP3 AQP10
3 urea transmembrane transporter activity GO:0015204 8.96 AQP3 AQP10
4 glycerol channel activity GO:0015254 8.62 AQP3 AQP10
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Sources for Pompholyx

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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