Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: PMP010
MIFTS: 35

Pompholyx

Categories: Skin diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Pompholyx

About this section

MalaCards integrated aliases for Pompholyx:

Name: Pompholyx 12 15
Vesicular Eczema of Hands and/or Feet 12 72
Dyshidrosis 12 17
Vesicular Hand Eczema 72
Eczema, Dyshidrotic 44
Dyshydrotic Eczema 12
Cheiropompholyx 12

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:9230
ICD9CM 35 705.81
MeSH 44 D011146
SNOMED-CT 68 25560004
ICD10 33 L30.1
UMLS 72 C0032633 C1535513
Sources

Summaries for Pompholyx

About this section
Disease Ontology : 12 A sweat gland disease that is characterized by recurrent vesicles and bullae that develop particularly upon the lateral palms, soles, and fingers and has symptom pruritis and cracked skin.

MalaCards based summary : Pompholyx, also known as vesicular eczema of hands and/or feet, is related to palmoplantar carcinoma, multiple self-healing and dermatitis, and has symptoms including pruritis and pustular rash. An important gene associated with Pompholyx is TGM5 (Transglutaminase 5). The drugs Alitretinoin and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells, and related phenotype is taste/olfaction.

Wikipedia : 75 Dyshidrosis, is a type of dermatitis, that is characterized by itchy blisters on the palms of the hands... more...

Sources

Related Diseases for Pompholyx

About this section

Diseases related to Pompholyx via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 palmoplantar carcinoma, multiple self-healing 11.3
2 dermatitis 10.7
3 anhidrosis 10.4
4 contact dermatitis 10.3
5 bullous pemphigoid 10.3
6 pulmonary alveolar microlithiasis 10.2
7 skin disease 10.2
8 fabry disease 10.2
9 ige responsiveness, atopic 10.1
10 pemphigus vulgaris, familial 10.1
11 dermatitis, atopic 10.1
12 metal allergy 10.1
13 allergic hypersensitivity disease 10.1
14 pemphigus 10.1
15 48,xyyy 10.1
16 syringomyelia, noncommunicating isolated 10.0
17 mycosis fungoides 10.0
18 incontinentia pigmenti 10.0
19 peeling skin syndrome 2 10.0
20 pain sensitivity quantitative trait locus 1 10.0
21 peripheral t-cell lymphoma 10.0
22 peeling skin syndrome 10.0
23 amenorrhea 10.0
24 candidiasis 10.0
25 ectodermal dysplasia 10.0
26 epidermolysis bullosa 10.0
27 syringomyelia 10.0
28 purpura 10.0
29 spongiotic dermatitis 10.0
30 epidermolysis bullosa simplex 10.0
31 herpes zoster 10.0
32 neuropathy 10.0
33 diabetes mellitus 10.0
34 diabetic neuropathy 10.0
35 chiari malformation 10.0
36 nevus of ota 10.0
37 amyotrophic lateral sclerosis 1 10.0
38 polykaryocytosis inducer 10.0
39 pemphigus gestationis 10.0
40 exanthem 10.0
41 adult t-cell leukemia 10.0
42 lymphoma 10.0
43 neutropenia 10.0
44 leukemia 10.0
45 tinea pedis 10.0
46 pancytopenia 10.0
47 guillain-barre syndrome 10.0
48 pemphigoid gestationis 10.0
49 lateral sclerosis 10.0
50 vesiculobullous skin disease 10.0

Graphical network of the top 20 diseases related to Pompholyx:



Diseases related to Pompholyx
Sources

Symptoms & Phenotypes for Pompholyx

About this section

Symptoms:

12
  • • pruritis

UMLS symptoms related to Pompholyx:


pustular rash

MGI Mouse Phenotypes related to Pompholyx:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 taste/olfaction MP:0005394 8.62 AQP3 PDE4A
Sources

Drugs & Therapeutics for Pompholyx

About this section

Drugs for Pompholyx (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alitretinoin Approved, Investigational Phase 3 5300-03-8 444795 449171
2
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
3
Isotretinoin Approved Phase 3 4759-48-2 5282379 5538
4
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
5
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
6
Ketoconazole Approved, Investigational Phase 3 65277-42-1 47576
7
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
8
Betamethasone Approved, Vet_approved Phase 3 378-44-9 9782
9
Tretinoin Approved, Investigational, Nutraceutical Phase 3 302-79-4 5538 444795
10 Dermatologic Agents Phase 3
11 Antifungal Agents Phase 3
12 Anti-Infective Agents Phase 3
13 Cyclosporins Phase 3
14 Immunosuppressive Agents Phase 3
15 Immunologic Factors Phase 3
16 Calcineurin Inhibitors Phase 3
17 Antirheumatic Agents Phase 3
18 14-alpha Demethylase Inhibitors Phase 3
19 Gastrointestinal Agents Phase 3
20 Cytochrome P-450 CYP3A Inhibitors Phase 3
21 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
22 Antiemetics Phase 3
23 Anti-Inflammatory Agents Phase 3
24 Hormones Phase 3
25 Respiratory System Agents Phase 3
26 Peripheral Nervous System Agents Phase 3
27 Cytochrome P-450 Enzyme Inhibitors Phase 3
28 HIV Protease Inhibitors Phase 3
29 Steroid Synthesis Inhibitors Phase 3
30 glucocorticoids Phase 3
31
protease inhibitors Phase 3
32 Anti-Infective Agents, Local Phase 3
33 Antineoplastic Agents, Hormonal Phase 3
34 Hormone Antagonists Phase 3
35 Autonomic Agents Phase 3
36 Anti-Asthmatic Agents Phase 3
37 Betamethasone-17,21-dipropionate Phase 3
38 Betamethasone Valerate Phase 3 2152-44-5
39 BB 1101 Phase 3
40 Betamethasone sodium phosphate Phase 3
41 Betamethasone benzoate Phase 3
42 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
43 Dandelion

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Alitretinoin in the Treatment of Severe Chronic Hand Eczema Refractory to Topical Therapy Completed NCT00817063 Phase 3 alitretinoin;Placebo
2 Efficacy of Oral Alitretinoin Versus Oral Cyclosporine in Patients With Severe Recurrent Vesicular Hand Eczema. A Randomized Prospective Open-label Trial With Blinded Outcome Assessment Recruiting NCT03026946 Phase 3 Alitretinoin;cyclosporin A
3 Phase 3 Study, Randomized, Double-blind, Parallel to Evaluate Ketoconazole and Betamethasone Dipropionate(Candicort®) Compared to Clotrimazole and Dexamethasone Acetate(Baycuten N®) in Relief of Fungal Infections/Dermatophytosis Symptoms. Recruiting NCT02582177 Phase 3 Candicort®;Nizoral®;Baycuten N®;Canesten®
4 Dandelion Juice in the Treatment of Dyshidrotic Hand Eczema Recruiting NCT00442091 dandelion juice

Search NIH Clinical Center for Pompholyx

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Bendazac

Cochrane evidence based reviews: eczema, dyshidrotic

Sources

Genetic Tests for Pompholyx

About this section
Sources

Anatomical Context for Pompholyx

About this section

MalaCards organs/tissues related to Pompholyx:

41
Skin, Testes, T Cells
Sources

Publications for Pompholyx

About this section

Articles related to Pompholyx:

(show top 50) (show all 154)
# Title Authors PMID Year
1
Pompholyx vesicles contain small clusters of cells with high levels of hyaluronate resembling the pustulovesicles of palmoplantar pustulosis. 38
31254390 2019
2
Diagnostic histopathological features distinguishing palmoplantar pustulosis from pompholyx. 38
30919463 2019
3
Botulinum toxin (Botox) A for reducing the appearance of facial wrinkles: a literature review of clinical use and pharmacological aspect. 38
31114283 2019
4
The microbiome of the "sterile" pustules in palmoplantar pustulosis. 38
30281856 2018
5
Non-cosmetic dermatological uses of botulinum neurotoxin. 38
27421250 2016
6
Patch Test as a Diagnostic Tool in Hand Eczema. 38
28050486 2016
7
Photoaggravated pompholyx. 38
26868937 2016
8
Pompholyx as a clinical manifestation suggesting increased serum IgG levels in a patient with drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. 38
26412450 2016
9
Pompholyx-like skin manifestation of adult T-cell leukemia/lymphoma. 38
26474722 2016
10
Dyshidrotic Eczema and Its Relationship to Metal Allergy. 38
27584966 2016
11
A Severe Case of Recalcitrant Pompholyx. 38
25876642 2015
12
Eccrine Chromhidrosis Resembling Clinical Features of Pompholyx with Bile-Like Greenish Pigmentation on the Right Palm and Soles. 38
26273179 2015
13
Single-Port Microthoracoscopic Sympathicotomy for the Treatment of Primary Palmar Hyperhidrosis: an Analysis of 56 Consecutive Cases. 38
26702233 2015
14
The key role of aquaporin 3 and aquaporin 10 in the pathogenesis of pompholyx. 38
25725905 2015
15
Pompholyx-like manifestation in Churg-Strauss syndrome. 38
25547649 2015
16
Unusual presentation of severe pompholyx. 38
25506565 2014
17
Dyshidrosiform presentation (pompholyx-like) of pemphigoid gestationis with intrauterine fetal death. 38
23432199 2014
18
Clinical and contact allergological observations on hand eczema: a descriptive study. 38
25799809 2014
19
Eczema and dermatitis in the afloat population: an overview of the assessment and management of the common erythematous skin conditions encountered in adults deployed on afloat platforms. 38
25895402 2014
20
Pompholyx of the hands after intravenous immunoglobulin therapy for clinically isolated syndrome: a paediatric case. 38
24674688 2014
21
A comparison of inflammatory mediator expression between palmoplantar pustulosis and pompholyx. 38
23802874 2013
22
Utility of epithelial membrane antigen immunostaining in the differentiation between palmoplantar pustulosis and pompholyx. 38
22988903 2013
23
Histological differentiation between palmoplantar pustulosis and pompholyx. 38
22691103 2013
24
Vesicular palmoplantar pityriasis rosea. 38
22545332 2012
25
Hand eczema: correlation of morphologic patterns, atopy, contact sensitization and disease severity. 38
22421645 2012
26
Pompholyx and eczematous reactions associated with intravenous immunoglobulin therapy. 38
21601310 2012
27
Vesico-bullous rash caused by pompholyx eczema. 38
22665876 2012
28
Detection of a novel single nucleotide polymorphism of the human thiopurine s-methyltransferase gene in a Chinese individual. 38
22447118 2012
29
Thoracoscopic Sympathicotomy vs Sympathectomy in Primary Hyperhidrosis. 38
24350109 2012
30
[Pompholyx-like reactions occurring early in treatment of severe atopic dermatitis in children and adolescence]. 38
22270129 2011
31
Topical and systemic therapies for nickel allergy. 38
22652902 2011
32
Seasonal variations in zooplankton abundances in the Iturbide reservoir (Isidro Fabela, State of Mexico, Mexico). 38
22315826 2011
33
[A case of dyshidrosiform pemphigoid]. 38
21702123 2011
34
Unilateral palm pompholyx in a patient with amyotrophic lateral sclerosis. 38
21561836 2011
35
Case study 4--A 35-year old male handyman with pompholyx blisters. 38
21309814 2011
36
[Monthly low-dose immunoglobulin infusion as a maintenance therapy for multifocal motor neuropathy may reduce allergic adverse effects: a case report]. 38
20803965 2010
37
Pemphigus vulgaris of the pompholyx type. 38
20403799 2010
38
Hand dermatitis/eczema: current management strategy. 38
20629825 2010
39
A case of palmar lichen nitidus presenting as a clinical feature of pompholyx. 38
20548925 2010
40
Pompholyx with bile-coloured vesicles in a patient with jaundice: are sweat ducts involved in the development of pompholyx? 38
19686259 2010
41
Pompholyx: a review of clinical features, differential diagnosis, and management. 38
20642293 2010
42
Dyshidrotic eczema: relevance to the immune response in situ. 38
22666682 2009
43
Acute and recurrent vesicular hand dermatitis. 38
19580928 2009
44
Hand dermatitis and lymphoedema. 38
19298277 2009
45
Pompholyx after intravenous immunoglobulin therapy for treatment of Guillain-Barré syndrome. 38
18761548 2009
46
[A new case of systemic contact eczema to nickel in a peripheral venous catheter]. 38
19061658 2008
47
Hand eczema: diagnosis and management. 38
19202671 2008
48
Patterns of lower leg and foot eczema in South India. 38
19052403 2008
49
Pompholyx: what's new? 38
18491990 2008
50
"Macular arteritis": a latent form of cutaneous polyarteritis nodosa? 38
18360118 2008
Sources

Variations for Pompholyx

About this section
Sources

Expression for Pompholyx

About this section
Search GEO for disease gene expression data for Pompholyx.
Sources

Pathways for Pompholyx

About this section
Sources

GO Terms for Pompholyx

About this section

Cellular components related to Pompholyx according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell junction GO:0005911 8.62 COL17A1 AQP3

Biological processes related to Pompholyx according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 8.96 TGM5 KRT4
2 epidermis development GO:0008544 8.62 TGM5 COL17A1
Sources

Sources for Pompholyx

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....