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MCID: PMP010
MIFTS: 31

Pompholyx

Categories: Skin diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Pompholyx

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MalaCards integrated aliases for Pompholyx:

Name: Pompholyx 12 15
Vesicular Eczema of Hands and/or Feet 12 73
Vesicular Hand Eczema 73
Eczema, Dyshidrotic 44
Dyshydrotic Eczema 12
Cheiropompholyx 12
Dyshidrosis 12

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 33


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Summaries for Pompholyx

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MalaCards based summary : Pompholyx, also known as vesicular eczema of hands and/or feet, is related to palmoplantar carcinoma, multiple self-healing and amyotrophic lateral sclerosis 1, and has symptoms including pustular rash An important gene associated with Pompholyx is TGM5 (Transglutaminase 5). The drugs Alitretinoin and Tretinoin have been mentioned in the context of this disorder. Affiliated tissues include skin and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Dyshidrosis, is a type of dermatitis, that is characterized by itchy blisters on the palms of the hands... more...

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Related Diseases for Pompholyx

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Diseases related to Pompholyx via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 palmoplantar carcinoma, multiple self-healing 10.9
2 amyotrophic lateral sclerosis 1 9.8
3 pemphigus vulgaris, familial 9.8
4 adult t-cell leukemia 9.8
5 leukemia 9.8
6 neutropenia 9.8
7 pemphigus vulgaris 9.8
8 lymphoma 9.8
9 pancytopenia 9.8
10 lateral sclerosis 9.8
11 dermatitis 9.8
12 churg-strauss syndrome 9.8
13 t-cell leukemia 9.8
14 lichen nitidus 9.8
15 pemphigus 9.8
16 allergic angiitis 9.8
17 chromhidrosis 9.8
18 linear iga disease 9.8
19 pemphigoid gestationis 9.8
20 bullous skin disease 9.6 ATP2A2 COL17A1
21 subcorneal pustular dermatosis 9.5 ATP2A2 COL17A1
22 skin disease 9.2 ATP2A2 COL17A1

Graphical network of the top 20 diseases related to Pompholyx:



Diseases related to Pompholyx
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Symptoms & Phenotypes for Pompholyx

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UMLS symptoms related to Pompholyx:


pustular rash

GenomeRNAi Phenotypes related to Pompholyx according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.58 AQP3 TGM5
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.58 TGM5
3 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.58 AQP3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-129 9.58 AQP3
5 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.58 TGM5
6 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.58 TGM5
7 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.58 AQP3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.58 TGM5
9 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.58 AQP3
10 Increased shRNA abundance (Z-score > 2) GR00366-A-162 9.58 TGM5
11 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.58 AQP3
12 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.58 AQP3
13 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.58 TGM5
14 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.58 AQP3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.58 AQP3
16 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.58 TGM5
17 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.58 TGM5
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Drugs & Therapeutics for Pompholyx

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Drugs for Pompholyx (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alitretinoin Approved, Investigational Phase 3 5300-03-8 444795 449171
2
Tretinoin Approved, Investigational, Nutraceutical Phase 3 302-79-4 5538 444795
3 Dermatologic Agents Phase 3
4 Keratolytic Agents Phase 3
5 Dandelion Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of a Retinoid in the Treatment of Severe Chronic Hand Eczema Completed NCT00817063 Phase 3 alitretinoin;Placebo
2 Dandelion Juice in the Treatment of Dyshidrotic Hand Eczema Recruiting NCT00442091 Not Applicable dandelion juice

Search NIH Clinical Center for Pompholyx

Cochrane evidence based reviews: eczema, dyshidrotic

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Genetic Tests for Pompholyx

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Anatomical Context for Pompholyx

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MalaCards organs/tissues related to Pompholyx:

41
Skin, T Cells
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Publications for Pompholyx

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Articles related to Pompholyx:

(show all 28)
# Title Authors Year
1
Photoaggravated pompholyx. ( 26868937 )
2016
2
Pompholyx as a clinical manifestation suggesting increased serum IgG levels in a patient with drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. ( 26412450 )
2016
3
Pompholyx-like skin manifestation of adult T-cell leukemia/lymphoma. ( 26474722 )
2015
4
A Severe Case of Recalcitrant Pompholyx. ( 25876642 )
2015
5
The key role of aquaporin 3 and aquaporin 10 in the pathogenesis of pompholyx. ( 25725905 )
2015
6
Eccrine Chromhidrosis Resembling Clinical Features of Pompholyx with Bile-Like Greenish Pigmentation on the Right Palm and Soles. ( 26273179 )
2015
7
Unusual presentation of severe pompholyx. ( 25506565 )
2014
8
Pompholyx-like manifestation in Churg-Strauss syndrome. ( 25547649 )
2014
9
Pompholyx of the hands after intravenous immunoglobulin therapy for clinically isolated syndrome: a paediatric case. ( 24674688 )
2014
10
Utility of epithelial membrane antigen immunostaining in the differentiation between palmoplantar pustulosis and pompholyx. ( 22988903 )
2013
11
A comparison of inflammatory mediator expression between palmoplantar pustulosis and pompholyx. ( 23802874 )
2013
12
Dyshidrosiform presentation (pompholyx-like) of pemphigoid gestationis with intrauterine fetal death. ( 23432199 )
2013
13
Histological differentiation between palmoplantar pustulosis and pompholyx. ( 22691103 )
2013
14
Vesico-bullous rash caused by pompholyx eczema. ( 22665876 )
2012
15
Pompholyx and eczematous reactions associated with intravenous immunoglobulin therapy. ( 21601310 )
2012
16
Unilateral palm pompholyx in a patient with amyotrophic lateral sclerosis. ( 21561836 )
2011
17
Case study 4--A 35-year old male handyman with pompholyx blisters. ( 21309814 )
2011
18
Blastomycosis-like pyoderma in association with recurrent vesicular hand eczema: good response to acitretin. ( 21426875 )
2011
19
Pompholyx: a review of clinical features, differential diagnosis, and management. ( 20642293 )
2010
20
A case of palmar lichen nitidus presenting as a clinical feature of pompholyx. ( 20548925 )
2010
21
Bullous pemphigoid masquerading as recurrent vesicular hand eczema. ( 20107717 )
2010
22
Pemphigus vulgaris of the pompholyx type. ( 20403799 )
2010
23
Acute and recurrent vesicular hand dermatitis not pompholyx or dyshidrosis. ( 18087011 )
2007
24
Azathioprine-induced pancytopenia in a patient with pompholyx and deficiency of erythrocyte thiopurine methyltransferase. ( 15705694 )
2005
25
Epidemiological, clinical and allergological observations on pompholyx. ( 1534730 )
1992
26
Linear IgA disease with haemorrhagic pompholyx and dapsone-induced neutropenia. ( 1832928 )
1991
27
Pompholyx (dyshidrosis). A case study. ( 3156983 )
1985
28
Atypical pompholyx (dyshidrosis): a case presentation. ( 126255 )
1975
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Variations for Pompholyx

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Expression for Pompholyx

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Search GEO for disease gene expression data for Pompholyx.
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Pathways for Pompholyx

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GO Terms for Pompholyx

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Cellular components related to Pompholyx according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell junction GO:0005911 8.62 AQP3 COL17A1

Biological processes related to Pompholyx according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 8.8 ATP2A2 COL17A1 TGM5
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Sources for Pompholyx

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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