Aliases & Classifications for Pompholyx

MalaCards integrated aliases for Pompholyx:

Name: Pompholyx 12 15
Vesicular Eczema of Hands and/or Feet 12 74
Dyshidrosis 12 17
Vesicular Hand Eczema 74
Eczema, Dyshidrotic 45
Dyshydrotic Eczema 12
Cheiropompholyx 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9230
ICD9CM 36 705.81
MeSH 45 D011146
SNOMED-CT 69 25560004
ICD10 34 L30.1

Summaries for Pompholyx

Disease Ontology : 12 A sweat gland disease that is characterized by recurrent vesicles and bullae that develop particularly upon the lateral palms, soles, and fingers and has symptom pruritis and cracked skin.

MalaCards based summary : Pompholyx, also known as vesicular eczema of hands and/or feet, is related to palmoplantar carcinoma, multiple self-healing and dermatitis, and has symptoms including pruritis and pustular rash. An important gene associated with Pompholyx is TGM5 (Transglutaminase 5). The drugs Alitretinoin and Dermatologic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Dyshidrosis, is a type of dermatitis, that is characterized by itchy blisters on the palms of the hands... more...

Related Diseases for Pompholyx

Diseases related to Pompholyx via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 palmoplantar carcinoma, multiple self-healing 11.1
2 dermatitis 10.4
3 fabry disease 10.1
4 anhidrosis 10.1
5 pulmonary alveolar microlithiasis 10.1
6 contact dermatitis 10.1
7 bullous pemphigoid 10.1
8 mycosis fungoides 9.9
9 insensitivity to pain, congenital, with anhidrosis 9.9
10 incontinentia pigmenti 9.9
11 neuropathy, hereditary sensory and autonomic, type v 9.9
12 pain sensitivity quantitative trait locus 1 9.9
13 diabetes mellitus 9.9
14 diabetic neuropathy 9.9
15 ectodermal dysplasia 9.9
16 peripheral t-cell lymphoma 9.9
17 syringomyelia 9.9
18 herpes zoster 9.9
19 neuropathy 9.9
20 nevus of ota 9.9
21 amyotrophic lateral sclerosis 1 9.9
22 pemphigus vulgaris, familial 9.9
23 dermatitis, atopic 9.9
24 adult t-cell leukemia 9.9
25 leukemia 9.9
26 neutropenia 9.9
27 pemphigus vulgaris 9.9
28 pemphigus gestationis 9.9
29 lymphoma 9.9
30 metal allergy 9.9
31 allergic hypersensitivity disease 9.9
32 pancytopenia 9.9
33 guillain-barre syndrome 9.9
34 pemphigoid gestationis 9.9
35 lateral sclerosis 9.9
36 churg-strauss syndrome 9.9
37 human immunodeficiency virus infectious disease 9.9
38 t-cell leukemia 9.9
39 lichen nitidus 9.9
40 pemphigus 9.9
41 hypereosinophilic syndrome 9.9
42 allergic angiitis 9.9
43 chromhidrosis 9.9
44 drug reaction with eosinophilia and systemic symptoms 9.9
45 eosinophilic granulomatosis with polyangiitis 9.9
46 linear iga disease 9.9

Graphical network of the top 20 diseases related to Pompholyx:



Diseases related to Pompholyx

Symptoms & Phenotypes for Pompholyx

Symptoms:

12
  • pruritis

UMLS symptoms related to Pompholyx:


pustular rash

GenomeRNAi Phenotypes related to Pompholyx according to GeneCards Suite gene sharing:

27 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.87 TGM5 AQP3
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.87 TGM5
3 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.87 AQP3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-129 9.87 AQP3
5 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.87 KRT4
6 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.87 TGM5
7 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.87 KRT4
8 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.87 TGM5
9 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.87 AQP3
10 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.87 KRT4
11 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.87 TGM5
12 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.87 AQP3
13 Increased shRNA abundance (Z-score > 2) GR00366-A-162 9.87 TGM5
14 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.87 KRT4
15 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.87 KRT4
16 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.87 AQP3
17 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.87 KRT4
18 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.87 AQP3
19 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.87 TGM5
20 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.87 AQP3
21 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.87 AQP3
22 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.87 KRT4
23 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.87 KRT4 TGM5
24 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.87 TGM5

MGI Mouse Phenotypes related to Pompholyx:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 taste/olfaction MP:0005394 8.62 AQP3 PDE4A

Drugs & Therapeutics for Pompholyx

Drugs for Pompholyx (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alitretinoin Approved, Investigational Phase 3 5300-03-8 449171 444795
2 Dermatologic Agents Phase 3
3 Dandelion Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of a Retinoid in the Treatment of Severe Chronic Hand Eczema Completed NCT00817063 Phase 3 alitretinoin;Placebo
2 Dandelion Juice in the Treatment of Dyshidrotic Hand Eczema Recruiting NCT00442091 Not Applicable dandelion juice

Search NIH Clinical Center for Pompholyx

Cochrane evidence based reviews: eczema, dyshidrotic

Genetic Tests for Pompholyx

Anatomical Context for Pompholyx

MalaCards organs/tissues related to Pompholyx:

42
Skin, T Cells, Testes

Publications for Pompholyx

Articles related to Pompholyx:

(show top 50) (show all 87)
# Title Authors Year
1
Diagnostic histopathological features distinguishing palmoplantar pustulosis from pompholyx. ( 30919463 )
2019
2
Study protocol: efficacy of oral alitretinoin versus oral cyclosporine A in patients with severe recurrent vesicular hand eczema (ALICsA): a randomised prospective open-label trial with blinded outcome assessment. ( 29997136 )
2018
3
Patch testing in patients with recurrent vesicular hand eczema. ( 28381367 )
2017
4
Pompholyx-like skin manifestation of adult T-cell leukemia/lymphoma. ( 26474722 )
2016
5
Pompholyx as a clinical manifestation suggesting increased serum IgG levels in a patient with drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. ( 26412450 )
2016
6
Photoaggravated pompholyx. ( 26868937 )
2016
7
Eccrine Chromhidrosis Resembling Clinical Features of Pompholyx with Bile-Like Greenish Pigmentation on the Right Palm and Soles. ( 26273179 )
2015
8
Pompholyx-like manifestation in Churg-Strauss syndrome. ( 25547649 )
2015
9
The key role of aquaporin 3 and aquaporin 10 in the pathogenesis of pompholyx. ( 25725905 )
2015
10
A Severe Case of Recalcitrant Pompholyx. ( 25876642 )
2015
11
Dyshidrosiform presentation (pompholyx-like) of pemphigoid gestationis with intrauterine fetal death. ( 23432199 )
2014
12
Pompholyx of the hands after intravenous immunoglobulin therapy for clinically isolated syndrome: a paediatric case. ( 24674688 )
2014
13
Unusual presentation of severe pompholyx. ( 25506565 )
2014
14
Histological differentiation between palmoplantar pustulosis and pompholyx. ( 22691103 )
2013
15
Utility of epithelial membrane antigen immunostaining in the differentiation between palmoplantar pustulosis and pompholyx. ( 22988903 )
2013
16
A comparison of inflammatory mediator expression between palmoplantar pustulosis and pompholyx. ( 23802874 )
2013
17
Increase in vesicular hand eczema after house dust mite inhalation provocation: a double-blind, placebo-controlled, cross-over study. ( 23046099 )
2013
18
Pompholyx and eczematous reactions associated with intravenous immunoglobulin therapy. ( 21601310 )
2012
19
Vesico-bullous rash caused by pompholyx eczema. ( 22665876 )
2012
20
Blastomycosis-like pyoderma in association with recurrent vesicular hand eczema: good response to acitretin. ( 21426875 )
2011
21
Case study 4--A 35-year old male handyman with pompholyx blisters. ( 21309814 )
2011
22
Unilateral palm pompholyx in a patient with amyotrophic lateral sclerosis. ( 21561836 )
2011
23
Bullous pemphigoid masquerading as recurrent vesicular hand eczema. ( 20107717 )
2010
24
A case of palmar lichen nitidus presenting as a clinical feature of pompholyx. ( 20548925 )
2010
25
Pemphigus vulgaris of the pompholyx type. ( 20403799 )
2010
26
Pompholyx with bile-coloured vesicles in a patient with jaundice: are sweat ducts involved in the development of pompholyx? ( 19686259 )
2010
27
Pompholyx: a review of clinical features, differential diagnosis, and management. ( 20642293 )
2010
28
Pompholyx after intravenous immunoglobulin therapy for treatment of Guillain-Barré syndrome. ( 18761548 )
2009
29
Pompholyx: what's new? ( 18491990 )
2008
30
Pompholyx eczema as a manifestation of HIV infection, response to antiretroviral therapy. ( 17598050 )
2007
31
Pompholyx induced by intravenous immunoglobulin therapy. ( 17694704 )
2007
32
Pompholyx. ( 17902549 )
2007
33
A 3-year causative study of pompholyx in 120 patients. ( 18086998 )
2007
34
Acute and recurrent vesicular hand dermatitis not pompholyx or dyshidrosis. ( 18087011 )
2007
35
Recalcitrant hand pompholyx: variable response to etanercept. ( 16309517 )
2006
36
The gene for a rare autosomal dominant form of pompholyx maps to chromosome 18q22.1-18q22.3. ( 16374448 )
2006
37
Azathioprine-induced pancytopenia in a patient with pompholyx and deficiency of erythrocyte thiopurine methyltransferase. ( 15705694 )
2005
38
Topical khellin and natural sunlight in the outpatient treatment of recalcitrant palmoplantar pompholyx: report of an open pilot study. ( 16286756 )
2005
39
Photoinduced pompholyx: a report of 5 cases. ( 14699365 )
2004
40
Role of contact allergens in pompholyx. ( 15187338 )
2004
41
Pharmacotherapy of pompholyx. ( 15212602 )
2004
42
Severe pompholyx following endoscopic thoracic sympathectomy for palmar hyperhidrosis. ( 17670319 )
2004
43
What you need to know about... pompholyx eczema. ( 14603652 )
2003
44
Constitutional pompholyx eczema complicated by secondary lymphoedema. ( 11859954 )
2001
45
Pompholyx after IV immunoglobulin therapy for neurologic disease. ( 10802813 )
2000
46
Low-dose oral methotrexate treatment for recalcitrant palmoplantar pompholyx. ( 10188683 )
1999
47
Pompholyx (vesicular eczema) after i.v. immunoglobulin therapy for neurologic disease. ( 10496291 )
1999
48
Pompholyx: a still unresolved kind of eczema. ( 8513186 )
1993
49
The role of metal allergy and local hyperhidrosis in the pathogenesis of pompholyx. ( 1293189 )
1992
50
Epidemiological, clinical and allergological observations on pompholyx. ( 1534730 )
1992

Variations for Pompholyx

Expression for Pompholyx

Search GEO for disease gene expression data for Pompholyx.

Pathways for Pompholyx

GO Terms for Pompholyx

Cellular components related to Pompholyx according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell junction GO:0005911 8.62 AQP3 COL17A1

Biological processes related to Pompholyx according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 8.96 KRT4 TGM5
2 epidermis development GO:0008544 8.62 COL17A1 TGM5

Sources for Pompholyx

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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