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MCID: PMP010
MIFTS: 35

Pompholyx

Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Pompholyx

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MalaCards integrated aliases for Pompholyx:

Name: Pompholyx 12 15
Vesicular Eczema of Hands and/or Feet 12 73
Vesicular Hand Eczema 73
Eczema, Dyshidrotic 44
Dyshydrotic Eczema 12
Cheiropompholyx 12
Dyshidrosis 12

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:9230
ICD9CM 35 705.81
MeSH 44 D011146
SNOMED-CT 68 25560004
ICD10 33 L30.1
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Summaries for Pompholyx

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MalaCards based summary : Pompholyx, also known as vesicular eczema of hands and/or feet, is related to dermatitis, atopic and palmoplantar carcinoma, multiple self-healing, and has symptoms including pustular rash An important gene associated with Pompholyx is TGM5 (Transglutaminase 5), and among its related pathways/superpathways is cAMP signaling pathway. The drugs Alitretinoin and Tretinoin have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Dyshidrosis, is a type of dermatitis, that is characterized by itchy blisters on the palms of the hands... more...

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Related Diseases for Pompholyx

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Diseases related to Pompholyx via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 dermatitis, atopic 29.3 IL9 PDE4A
2 palmoplantar carcinoma, multiple self-healing 11.1
3 dermatitis 10.3
4 contact dermatitis 10.0
5 bullous pemphigoid 10.0
6 mycosis fungoides 9.9
7 insensitivity to pain, congenital, with anhidrosis 9.9
8 fabry disease 9.9
9 incontinentia pigmenti 9.9
10 neuropathy, hereditary sensory and autonomic, type v 9.9
11 ectodermal dysplasia 9.9
12 peripheral t-cell lymphoma 9.9
13 anhidrosis 9.9
14 syringomyelia 9.9
15 herpes zoster 9.9
16 nevus of ota 9.9
17 amyotrophic lateral sclerosis 1 9.9
18 adult t-cell leukemia 9.9
19 drug reaction with eosinophilia and systemic symptoms 9.9
20 linear iga disease 9.9
21 pemphigoid gestationis 9.9
22 chromhidrosis 9.9
23 allergic angiitis 9.9
24 pemphigus 9.9
25 lichen nitidus 9.9
26 t-cell leukemia 9.9
27 human immunodeficiency virus infectious disease 9.9
28 churg-strauss syndrome 9.9
29 lateral sclerosis 9.9
30 pancytopenia 9.9
31 metal allergy 9.9
32 lymphoma 9.9
33 pemphigus gestationis 9.9
34 pemphigus vulgaris 9.9
35 neutropenia 9.9
36 leukemia 9.9
37 pemphigus vulgaris, familial 9.9

Graphical network of the top 20 diseases related to Pompholyx:



Diseases related to Pompholyx
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Symptoms & Phenotypes for Pompholyx

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UMLS symptoms related to Pompholyx:


pustular rash

GenomeRNAi Phenotypes related to Pompholyx according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.91 AQP3 TGM5
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.91 TGM5
3 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.91 AQP3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-129 9.91 AQP3
5 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.91 TGM5
6 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.91 TGM5
7 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.91 AQP3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.91 TGM5
9 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.91 AQP3
10 Increased shRNA abundance (Z-score > 2) GR00366-A-162 9.91 TGM5
11 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.91 AQP3
12 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.91 AQP3
13 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.91 TGM5
14 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.91 AQP3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.91 AQP3
16 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.91 TGM5
17 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.91 TGM5
18 Reduced mammosphere formation GR00396-S 8.8 ATP2A2 IL9 PDE4A

MGI Mouse Phenotypes related to Pompholyx:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 taste/olfaction MP:0005394 8.62 AQP3 PDE4A
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Drugs & Therapeutics for Pompholyx

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Drugs for Pompholyx (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alitretinoin Approved, Investigational Phase 3 5300-03-8 449171 444795
2
Tretinoin Approved, Investigational, Nutraceutical Phase 3 302-79-4 5538 444795
3 Keratolytic Agents Phase 3
4 Dermatologic Agents Phase 3
5 Dandelion Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of a Retinoid in the Treatment of Severe Chronic Hand Eczema Completed NCT00817063 Phase 3 alitretinoin;Placebo
2 Dandelion Juice in the Treatment of Dyshidrotic Hand Eczema Recruiting NCT00442091 Not Applicable dandelion juice

Search NIH Clinical Center for Pompholyx

Cochrane evidence based reviews: eczema, dyshidrotic

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Genetic Tests for Pompholyx

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Anatomical Context for Pompholyx

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MalaCards organs/tissues related to Pompholyx:

41
Skin, Testes, T Cells
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Publications for Pompholyx

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Articles related to Pompholyx:

(show top 50) (show all 85)
# Title Authors Year
1
Study protocol: efficacy of oral alitretinoin versus oral cyclosporine A in patients with severe recurrent vesicular hand eczema (ALICsA): a randomised prospective open-label trial with blinded outcome assessment. ( 29997136 )
2018
2
Patch testing in patients with recurrent vesicular hand eczema. ( 28381367 )
2017
3
Photoaggravated pompholyx. ( 26868937 )
2016
4
Pompholyx as a clinical manifestation suggesting increased serum IgG levels in a patient with drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. ( 26412450 )
2016
5
Pompholyx-like skin manifestation of adult T-cell leukemia/lymphoma. ( 26474722 )
2015
6
A Severe Case of Recalcitrant Pompholyx. ( 25876642 )
2015
7
The key role of aquaporin 3 and aquaporin 10 in the pathogenesis of pompholyx. ( 25725905 )
2015
8
Eccrine Chromhidrosis Resembling Clinical Features of Pompholyx with Bile-Like Greenish Pigmentation on the Right Palm and Soles. ( 26273179 )
2015
9
Unusual presentation of severe pompholyx. ( 25506565 )
2014
10
Pompholyx-like manifestation in Churg-Strauss syndrome. ( 25547649 )
2014
11
Pompholyx of the hands after intravenous immunoglobulin therapy for clinically isolated syndrome: a paediatric case. ( 24674688 )
2014
12
Utility of epithelial membrane antigen immunostaining in the differentiation between palmoplantar pustulosis and pompholyx. ( 22988903 )
2013
13
A comparison of inflammatory mediator expression between palmoplantar pustulosis and pompholyx. ( 23802874 )
2013
14
Dyshidrosiform presentation (pompholyx-like) of pemphigoid gestationis with intrauterine fetal death. ( 23432199 )
2013
15
Histological differentiation between palmoplantar pustulosis and pompholyx. ( 22691103 )
2013
16
Vesico-bullous rash caused by pompholyx eczema. ( 22665876 )
2012
17
Pompholyx and eczematous reactions associated with intravenous immunoglobulin therapy. ( 21601310 )
2012
18
Unilateral palm pompholyx in a patient with amyotrophic lateral sclerosis. ( 21561836 )
2011
19
Case study 4--A 35-year old male handyman with pompholyx blisters. ( 21309814 )
2011
20
Blastomycosis-like pyoderma in association with recurrent vesicular hand eczema: good response to acitretin. ( 21426875 )
2011
21
Pompholyx: a review of clinical features, differential diagnosis, and management. ( 20642293 )
2010
22
A case of palmar lichen nitidus presenting as a clinical feature of pompholyx. ( 20548925 )
2010
23
Bullous pemphigoid masquerading as recurrent vesicular hand eczema. ( 20107717 )
2010
24
Pemphigus vulgaris of the pompholyx type. ( 20403799 )
2010
25
Pompholyx with bile-coloured vesicles in a patient with jaundice: are sweat ducts involved in the development of pompholyx? ( 19686259 )
2010
26
Pompholyx after intravenous immunoglobulin therapy for treatment of Guillain-Barré syndrome. ( 18761548 )
2009
27
Pompholyx: what's new? ( 18491990 )
2008
28
Acute and recurrent vesicular hand dermatitis not pompholyx or dyshidrosis. ( 18087011 )
2007
29
Pompholyx eczema as a manifestation of HIV infection, response to antiretroviral therapy. ( 17598050 )
2007
30
Pompholyx induced by intravenous immunoglobulin therapy. ( 17694704 )
2007
31
Pompholyx. ( 17902549 )
2007
32
A 3-year causative study of pompholyx in 120 patients. ( 18086998 )
2007
33
Recalcitrant hand pompholyx: variable response to etanercept. ( 16309517 )
2006
34
The gene for a rare autosomal dominant form of pompholyx maps to chromosome 18q22.1-18q22.3. ( 16374448 )
2006
35
Azathioprine-induced pancytopenia in a patient with pompholyx and deficiency of erythrocyte thiopurine methyltransferase. ( 15705694 )
2005
36
Topical khellin and natural sunlight in the outpatient treatment of recalcitrant palmoplantar pompholyx: report of an open pilot study. ( 16286756 )
2005
37
Photoinduced pompholyx: a report of 5 cases. ( 14699365 )
2004
38
Role of contact allergens in pompholyx. ( 15187338 )
2004
39
Pharmacotherapy of pompholyx. ( 15212602 )
2004
40
Severe pompholyx following endoscopic thoracic sympathectomy for palmar hyperhidrosis. ( 17670319 )
2004
41
What you need to know about... pompholyx eczema. ( 14603652 )
2003
42
Constitutional pompholyx eczema complicated by secondary lymphoedema. ( 11859954 )
2001
43
Pompholyx after IV immunoglobulin therapy for neurologic disease. ( 10802813 )
2000
44
Low-dose oral methotrexate treatment for recalcitrant palmoplantar pompholyx. ( 10188683 )
1999
45
Pompholyx (vesicular eczema) after i.v. immunoglobulin therapy for neurologic disease. ( 10496291 )
1999
46
Pompholyx: a still unresolved kind of eczema. ( 8513186 )
1993
47
Epidemiological, clinical and allergological observations on pompholyx. ( 1534730 )
1992
48
The role of metal allergy and local hyperhidrosis in the pathogenesis of pompholyx. ( 1293189 )
1992
49
Linear IgA disease with haemorrhagic pompholyx and dapsone-induced neutropenia. ( 1832928 )
1991
50
Hand dermatitis resembling pompholyx in nickel-sensitive patients. ( 1827063 )
1991
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Variations for Pompholyx

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Expression for Pompholyx

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Search GEO for disease gene expression data for Pompholyx.
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Pathways for Pompholyx

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Pathways related to Pompholyx according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
cAMP signaling pathway 37
Show member pathways
 10.93 ATP2A2 PDE4A
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GO Terms for Pompholyx

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Biological processes related to Pompholyx according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 8.62 ATP2A2 TGM5
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Sources for Pompholyx

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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