MCID: PSN006
MIFTS: 27

Posner-Schlossman Syndrome

Categories: Rare diseases

Aliases & Classifications for Posner-Schlossman Syndrome

MalaCards integrated aliases for Posner-Schlossman Syndrome:

Name: Posner-Schlossman Syndrome 53
Glaucomatocyclitic Crisis 53 73

Classifications:



Summaries for Posner-Schlossman Syndrome

MalaCards based summary : Posner-Schlossman Syndrome, also known as glaucomatocyclitic crisis, is related to glaucomatocyclitic crisis and iridocyclitis. An important gene associated with Posner-Schlossman Syndrome is HLA-DPA1 (Major Histocompatibility Complex, Class II, DP Alpha 1), and among its related pathways/superpathways are Allograft rejection and Influenza A. The drug Antiviral Agents has been mentioned in the context of this disorder. Affiliated tissues include endothelial and eye.

Related Diseases for Posner-Schlossman Syndrome

Diseases related to Posner-Schlossman Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 glaucomatocyclitic crisis 10.3
2 iridocyclitis 10.3
3 nonarteritic anterior ischemic optic neuropathy 10.3
4 ischemic optic neuropathy 10.3
5 uveitis 10.3
6 optic nerve disease 10.3
7 herpes simplex 10.3
8 neuropathy 10.3
9 fuchs' heterochromic uveitis 10.3
10 anterior uveitis 10.2
11 cytomegalovirus infection 10.2
12 helicobacter pylori infection 10.2
13 berylliosis 9.5 HLA-DPA1 HLA-DPB1
14 beryllium disease 9.4 HLA-DPA1 HLA-DPB1
15 chronic beryllium disease 9.3 HLA-DPA1 HLA-DPB1
16 celiac disease 1 9.2 HLA-DPA1 HLA-DPB1
17 systemic lupus erythematosus 9.0 HLA-DPA1 HLA-DPB1

Graphical network of the top 20 diseases related to Posner-Schlossman Syndrome:



Diseases related to Posner-Schlossman Syndrome

Symptoms & Phenotypes for Posner-Schlossman Syndrome

Drugs & Therapeutics for Posner-Schlossman Syndrome

Drugs for Posner-Schlossman Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antiviral Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Patient Registry of Posner-Schlossman Syndrome Recruiting NCT03233477

Search NIH Clinical Center for Posner-Schlossman Syndrome

Genetic Tests for Posner-Schlossman Syndrome

Anatomical Context for Posner-Schlossman Syndrome

MalaCards organs/tissues related to Posner-Schlossman Syndrome:

41
Endothelial, Eye

Publications for Posner-Schlossman Syndrome

Articles related to Posner-Schlossman Syndrome:

(show top 50) (show all 67)
# Title Authors Year
1
Different composition of intraocular immune mediators in Posner-Schlossman-Syndrome and Fuchs' Uveitis. ( 29944680 )
2018
2
Posner-Schlossman syndrome induced laser<i>in situ</i>keratomileusis keratectasia-a case report. ( 29062785 )
2017
3
Characteristics of cases needing advanced treatment for intractable Posner-Schlossman syndrome. ( 28399831 )
2017
4
In vivo Confocal Microscopy of Posner-Schlossman Syndrome: Comparison with herpes simplex keratitis, HLA-B27 anterior uveitis and acute attack of primary angle closure. ( 28852187 )
2017
5
Posner-Schlossman syndrome in Wenzhou, China: a retrospective review study. ( 28450379 )
2017
6
A novel HLA-G allele, HLA-G*01:01:01:07, was identified in a Chinese patient with Posner-Schlossman syndrome. ( 28557312 )
2017
7
Bilateral simultaneous presentation of Posner-Schlossman syndrome. ( 28486785 )
2017
8
Serum Th1 and Th17 related cytokines and autoantibodies in patients with Posner-Schlossman syndrome. ( 28384257 )
2017
9
Posner-Schlossman Syndrome. ( 28012873 )
2016
10
Human Leukocyte Antigens-B and -C Loci Associated with Posner-Schlossman Syndrome in a Southern Chinese Population. ( 26161794 )
2015
11
[Association of HLA-DPA1 and -DPB1 polymorphisms with Posner-Schlossman syndrome among southern Chinese Han population]. ( 25863099 )
2015
12
Glaucomatocyclitic crisis and glaucomatous optic neuropathy. ( 29018666 )
2015
13
Long-term efficacy of deep sclerectomy in Posner-Schlossman syndrome. ( 25616652 )
2015
14
Trabeculectomy ab interno (trabectome): yet another possibility in the treatment of uncontrolled glaucomatocyclitic crisis under systemic valganciclovir therapy? ( 26139050 )
2015
15
Detection of the progression of retinal nerve fiber layer loss by optical coherence tomography in a patient with glaucomatocyclitic crisis. ( 29018674 )
2015
16
Long-term oral therapy with valganciclovir in patients with Posner-Schlossman syndrome. ( 24287937 )
2014
17
Clinical Outcomes in Cytomegalovirus-Positive Posner-Schlossman Syndrome Patients Treated With Topical Ganciclovir Therapy. ( 25124264 )
2014
18
Concurrence of iridocorneal endothelial syndrome in a patient with glaucomatocyclitic crisis. ( 24790889 )
2014
19
Point-of-care monitoring of perioperative intraocular pressure using portable tonometry in a patient with Posner-Schlossman syndrome: a case report. ( 24729850 )
2014
20
Posner-Schlossman syndrome associated with cytomegalovirus infection: a case series from a non-endemic area. ( 24622824 )
2014
21
Optic disc atrophy in patient with Posner-Schlossman syndrome. ( 23204806 )
2012
22
Aqueous cytokine changes associated with Posner-Schlossman syndrome with and without human cytomegalovirus. ( 23028541 )
2012
23
Infectious theories of Posner-Schlossman syndrome. ( 21897144 )
2011
24
Posner-Schlossman glaucomatocyclitic crisis. ( 21958175 )
2011
25
Association between Helicobacter pylori infection and Posner-Schlossman syndrome. ( 19229276 )
2010
26
Peripheral vascular endothelial dysfunction in glaucomatocyclitic crisis: a preliminary study. ( 19684007 )
2010
27
Trabeculectomy in the management of glaucomatocyclitic crisis with visual field defect. ( 20482405 )
2010
28
Presumed Fuchs heterochromic iridocyclitis and Posner-Schlossman syndrome: comparison of cytomegalovirus-positive and -negative eyes. ( 19463548 )
2009
29
Presumed fuchs heterochromic iridocyclitis and Posner-Schlossman syndrome: comparison of cytomegalovirus-positive and negative eyes. ( 19027423 )
2008
30
Idiopathic no more: clues to the pathogenesis of Fuchs heterochromic iridocyclitis and glaucomatocyclitic crisis. ( 18435976 )
2008
31
Glaucomatocyclitic crisis in Edo State, Nigeria: report of two cases. ( 18817059 )
2008
32
Posner-Schlossman syndrome (glaucomatocyclitic crisis). ( 17177667 )
2007
33
Pressure phosphene self-tonometry in a patient with Posner-Schlossman syndrome. ( 16925696 )
2006
34
A case of glaucomatocyclitic crisis in the emergency department. ( 16431228 )
2006
35
Posner-Schlossman syndrome and medical certification. ( 17042259 )
2006
36
Cytomegalovirus in aetiology of Posner-Schlossman syndrome: evidence from quantitative polymerase chain reaction. ( 15543169 )
2005
37
Posner-Schlossman syndrome and nonarteritic anterior ischemic optic neuropathy. ( 14663306 )
2003
38
Nonarteritic anterior ischemic optic neuropathy associated with acute glaucoma secondary to Posner-Schlossman syndrome. ( 12523901 )
2003
39
Posner Schlossman syndrome. ( 11874732 )
2002
40
Trabeculectomy in the management of Posner-Schlossman syndrome. ( 12134994 )
2002
41
Is Posner Schlossman syndrome benign? ( 11320022 )
2001
42
Optic nerve head behavior in Posner-Schlossman syndrome. ( 11944864 )
2001
43
Selective reduction of the S-cone component of the electroretinogram in Posner-Schlossman syndrome. ( 11339583 )
2001
44
Glaucomatocyclitic crisis in a child. ( 10334370 )
1999
45
Posner-Schlossman syndrome: a case report. ( 10618850 )
1999
46
Glaucomatocyclitic crisis in a child. ( 9683163 )
1998
47
Bilateral glaucomatocyclitic crisis in a patient with Holmes Adie syndrome. ( 10703577 )
1998
48
Reversal of optic disc topography in patients with glaucomatocyclitic crisis after remission of attack. ( 9713778 )
1998
49
Possible role of herpes simplex virus in the origin of Posner-Schlossman syndrome. ( 7785697 )
1995
50
Apraclonidine in the management of glaucomatocyclitic crisis. ( 7958055 )
1994

Variations for Posner-Schlossman Syndrome

Expression for Posner-Schlossman Syndrome

Search GEO for disease gene expression data for Posner-Schlossman Syndrome.

Pathways for Posner-Schlossman Syndrome

Pathways related to Posner-Schlossman Syndrome according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.33 HLA-DPA1 HLA-DPB1
2
Show member pathways
12.27 HLA-DPA1 HLA-DPB1
3
Show member pathways
12.12 HLA-DPA1 HLA-DPB1
4
Show member pathways
12.07 HLA-DPA1 HLA-DPB1
5
Show member pathways
11.98 HLA-DPA1 HLA-DPB1
6 11.95 HLA-DPA1 HLA-DPB1
7
Show member pathways
11.88 HLA-DPA1 HLA-DPB1
8 11.83 HLA-DPA1 HLA-DPB1
9
Show member pathways
11.78 HLA-DPA1 HLA-DPB1
10 11.75 HLA-DPA1 HLA-DPB1
11
Show member pathways
11.72 HLA-DPA1 HLA-DPB1
12 11.64 HLA-DPA1 HLA-DPB1
13
Show member pathways
11.6 HLA-DPA1 HLA-DPB1
14 11.56 HLA-DPA1 HLA-DPB1
15 11.41 HLA-DPA1 HLA-DPB1
16
Show member pathways
11.36 HLA-DPA1 HLA-DPB1
17 11.27 HLA-DPA1 HLA-DPB1
18 11.14 HLA-DPA1 HLA-DPB1
19 10.91 HLA-DPA1 HLA-DPB1
20 10.37 HLA-DPA1 HLA-DPB1

GO Terms for Posner-Schlossman Syndrome

Cellular components related to Posner-Schlossman Syndrome according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 endosome GO:0005768 9.52 HLA-DPA1 HLA-DPB1
2 cell surface GO:0009986 9.51 HLA-DPA1 HLA-DPB1
3 Golgi membrane GO:0000139 9.49 HLA-DPA1 HLA-DPB1
4 lysosome GO:0005764 9.48 HLA-DPA1 HLA-DPB1
5 lysosomal membrane GO:0005765 9.46 HLA-DPA1 HLA-DPB1
6 endosome membrane GO:0010008 9.43 HLA-DPA1 HLA-DPB1
7 trans-Golgi network membrane GO:0032588 9.4 HLA-DPA1 HLA-DPB1
8 endocytic vesicle membrane GO:0030666 9.37 HLA-DPA1 HLA-DPB1
9 ER to Golgi transport vesicle membrane GO:0012507 9.32 HLA-DPA1 HLA-DPB1
10 transport vesicle membrane GO:0030658 9.26 HLA-DPA1 HLA-DPB1
11 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DPA1 HLA-DPB1
12 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DPA1 HLA-DPB1
13 MHC class II protein complex GO:0042613 8.62 HLA-DPA1 HLA-DPB1

Biological processes related to Posner-Schlossman Syndrome according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.49 HLA-DPA1 HLA-DPB1
2 immune response GO:0006955 9.48 HLA-DPA1 HLA-DPB1
3 T cell receptor signaling pathway GO:0050852 9.46 HLA-DPA1 HLA-DPB1
4 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.43 HLA-DPA1 HLA-DPB1
5 T cell costimulation GO:0031295 9.4 HLA-DPA1 HLA-DPB1
6 interferon-gamma-mediated signaling pathway GO:0060333 9.37 HLA-DPA1 HLA-DPB1
7 positive regulation of T cell proliferation GO:0042102 9.32 HLA-DPA1 HLA-DPB1
8 positive regulation of interferon-gamma production GO:0032729 9.26 HLA-DPA1 HLA-DPB1
9 antigen processing and presentation GO:0019882 9.16 HLA-DPA1 HLA-DPB1
10 positive regulation of T cell activation GO:0050870 8.96 HLA-DPA1 HLA-DPB1
11 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 8.62 HLA-DPA1 HLA-DPB1

Molecular functions related to Posner-Schlossman Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.62 HLA-DPA1 HLA-DPB1

Sources for Posner-Schlossman Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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