MCID: PST106
MIFTS: 33

Post-Cardiac Arrest Syndrome

Categories: Blood diseases, Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Post-Cardiac Arrest Syndrome

MalaCards integrated aliases for Post-Cardiac Arrest Syndrome:

Name: Post-Cardiac Arrest Syndrome 12 15
Post Cardiac Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0070306

Summaries for Post-Cardiac Arrest Syndrome

Disease Ontology : 12 A syndrome that is characterized by four main components

MalaCards based summary : Post-Cardiac Arrest Syndrome, also known as post cardiac syndrome, is related to cardiac arrest and encephalopathy. An important gene associated with Post-Cardiac Arrest Syndrome is RBM28 (RNA Binding Motif Protein 28), and among its related pathways/superpathways is Pertussis. The drugs Valproic Acid and Clonazepam have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and endothelial, and related phenotype is Synthetic lethal with vaccinia virus (VACV) infection.

Related Diseases for Post-Cardiac Arrest Syndrome

Diseases in the Cardiac Arrest family:

Post-Cardiac Arrest Syndrome

Diseases related to Post-Cardiac Arrest Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 cardiac arrest 10.8
2 encephalopathy 10.0
3 acrocallosal syndrome 10.0 RBM28 RFXANK
4 churg-strauss syndrome 10.0 HMGB1 THBD
5 cardiac conduction defect 9.9
6 brain injury 9.9
7 disseminated intravascular coagulation 9.9
8 status epilepticus 9.9
9 ischemia 9.9
10 pleuropneumonia 9.9 IRAK3 IRAK4
11 rheumatic disease 9.8 HMGB1 THBD

Graphical network of the top 20 diseases related to Post-Cardiac Arrest Syndrome:



Diseases related to Post-Cardiac Arrest Syndrome

Symptoms & Phenotypes for Post-Cardiac Arrest Syndrome

GenomeRNAi Phenotypes related to Post-Cardiac Arrest Syndrome according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.92 HMGB1 IRAK3 IRAK4 THBD

Drugs & Therapeutics for Post-Cardiac Arrest Syndrome

Drugs for Post-Cardiac Arrest Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
2
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
3 Kava Approved, Investigational, Nutraceutical Phase 4 9000-38-8
4 Neurotransmitter Agents Phase 4
5 Psychotropic Drugs Phase 4
6 GABA Modulators Phase 4
7 Central Nervous System Depressants Phase 4,Phase 3
8 Anticonvulsants Phase 4
9 GABA Agents Phase 4
10 Tranquilizing Agents Phase 4
11 Antimanic Agents Phase 4
12
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
13 Immunologic Factors Phase 3,Not Applicable
14 Calcineurin Inhibitors Phase 3
15 Cyclosporins Phase 3
16 Protective Agents Phase 3,Phase 2
17 Dermatologic Agents Phase 3
18 Antifungal Agents Phase 3
19 Antirheumatic Agents Phase 3
20 Immunosuppressive Agents Phase 3
21 Anti-Infective Agents Phase 3
22 Xenon Phase 3
23 Anesthetics Phase 3
24 Anesthetics, Inhalation Phase 3
25 Anesthetics, General Phase 3
26
Epoprostenol Approved Phase 2 61849-14-7, 35121-78-9 5280427 5282411
27
Iloprost Approved, Investigational Phase 2 78919-13-8 6443959
28
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 2 59-43-8, 70-16-6 1130
29
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
30
Vitamin C Approved, Nutraceutical Phase 2 50-81-7 5785 54670067
31 Tezosentan Investigational Phase 2 180384-57-0
32 Antihypertensive Agents Phase 2
33 Vasodilator Agents Phase 2
34 Platelet Aggregation Inhibitors Phase 2
35 Antioxidants Phase 2
36 Micronutrients Phase 2
37 Folate Phase 2
38 Vitamin B9 Phase 2
39 Thiamin Phase 2
40 Vitamins Phase 2
41 Trace Elements Phase 2
42 Vitamin B Complex Phase 2
43 Complement System Proteins Not Applicable

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 The Benefit of Prophylactic Anticonvulsant in Post Cardiac Arrest Syndrome With Induced Mild Hypothermia Unknown status NCT01083784 Phase 4 Use of prophylactic anticonvulsants (valproate, clonazepam);Control group
2 Trial of Different Hypothermia Temperatures in Patients Recovered From Out-of-hospital Cardiac Arrest Completed NCT01155622 Phase 4
3 Cyclosporine A in Cardiac Arrest Completed NCT01595958 Phase 3 Cyclosporine A
4 Xenon for Neuroprotection During Post-Cardiac Arrest Syndrome in Comatose Survivors of an Out of Hospital Cardiac Arrest Active, not recruiting NCT03176186 Phase 3
5 Endothelial Dysfunction in Resuscitated Cardiac Arrest Completed NCT02685618 Phase 2 Iloprost;Saline
6 Vitamin C in Post-cardiac Arrest Not yet recruiting NCT03509662 Phase 2 Vitamin C;Thiamine;Placebos
7 The Complement Lectin Pathway After Cardiac Arrest Unknown status NCT02826057 Not Applicable
8 Bacterial Infection Diagnosis Using Blood DNA Unknown status NCT00698919
9 Study of Survivors of Different Types of Cardiac Arrest and Their Neurological Recovery Unknown status NCT02033720
10 Histones and Free-plasma DNA After Cardiac Arrest Completed NCT02733146
11 Transitions Between Clinical Circulatory States After Out-of-hospital Cardiac Arrest Completed NCT02648061
12 The Effect of IABP Early Insertion on Mortality in Post Cardiac Arrest Patients With Acute Coronary Syndrome Recruiting NCT03638609 Not Applicable
13 Predicting Long-term Outcomes After Cardiac Arrest by Using Serum NGAL Recruiting NCT03615300
14 Bronchial Alpha Amylase as a Marker for Early Aspiration Pneumonia in Therapeutic Hypothermia. Recruiting NCT03007862
15 Prognostic Value of Ventricular Fibrillation Spectral Analysis in Sudden Cardiac Death Recruiting NCT03248557
16 Cerebral Oxymetry and Neurological Outcome in Therapeutic Hypothermia Recruiting NCT03024021
17 Cytokine Adsorption in Post-cardiac Arrest Syndrome in Patients Requiring Extracorporeal Cardiopulmonary Resuscitation Not yet recruiting NCT03685383 Not Applicable
18 Hemoadsorption With CytoSorb® in Post-Cardiac Arrest Syndrome Not yet recruiting NCT03523039 Not Applicable

Search NIH Clinical Center for Post-Cardiac Arrest Syndrome

Genetic Tests for Post-Cardiac Arrest Syndrome

Anatomical Context for Post-Cardiac Arrest Syndrome

MalaCards organs/tissues related to Post-Cardiac Arrest Syndrome:

41
Brain, Heart, Endothelial

Publications for Post-Cardiac Arrest Syndrome

Articles related to Post-Cardiac Arrest Syndrome:

(show top 50) (show all 71)
# Title Authors Year
1
Early Initiation of Continuous Renal Replacement Therapy Induces Fast Hypothermia and Improves Post-Cardiac Arrest Syndrome in a Porcine Model. ( 30335673 )
2018
2
Differential effect of mild therapeutic hypothermia depending on the findings of hypoxic encephalopathy on early CT images in patients with post-cardiac arrest syndrome. ( 29698752 )
2018
3
Accuracy of the first interpretation of early brain CT images for predicting the prognosis of post-cardiac arrest syndrome patients at the emergency department. ( 29721320 )
2018
4
Duration of Untreated Cardiac Arrest and Clinical Relevance of Animal Experiments: The Relationship Between the "No-Flow" Duration and the Severity of Post-Cardiac Arrest Syndrome in a Porcine Model. ( 28562475 )
2018
5
Systemic impact on secondary brain aggravation due to ischemia/reperfusion injury in post-cardiac arrest syndrome: a prospective observational study using high-mobility group box 1 protein. ( 28950909 )
2017
6
A novel scoring system for predicting the neurologic prognosis prior to the initiation of induced hypothermia in cases of post-cardiac arrest syndrome: the CAST score. ( 28490379 )
2017
7
Fast therapeutic hypothermia prevents post-cardiac arrest syndrome through cyclophilin D-mediated mitochondrial permeability transition inhibition. ( 28492973 )
2017
8
Factors Influencing the Quality of Standardized Treatment for Patients with Post-Cardiac Arrest Syndrome. ( 28765736 )
2017
9
Oxidative stress and abnormal cholesterol metabolism in patients with post-cardiac arrest syndrome. ( 28955127 )
2017
10
Coagulofibrinolytic Changes in Patients with Post-cardiac Arrest Syndrome. ( 29034235 )
2017
11
Post-cardiac arrest syndrome: pathological processes, biomarkers and vasopressor support, and potential therapeutic targets. ( 29055751 )
2017
12
Differences in coagulofibrinolytic changes between post-cardiac arrest syndrome of cardiac causes and hypoxic insults: a pilot study. ( 29123894 )
2017
13
Internal Mammary Artery Injury Related to Chest Compressions in a Patient with Post-cardiac Arrest Syndrome. ( 27181536 )
2016
14
High-mobility group box 1 is associated with neurological outcome in patients with post-cardiac arrest syndrome after out-of-hospital cardiac arrest. ( 27247778 )
2016
15
Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome - First-in-Human Pilot Study. ( 27334126 )
2016
16
Helium ventilation for treatment of post-cardiac arrest syndrome: A safety and feasibility study. ( 27473390 )
2016
17
Endothelial Dysfunction in Resuscitated Cardiac Arrest (ENDO-RCA): safety and efficacy of low-dose prostacyclin administration and blood pressure target in addition to standard therapy, as compared to standard therapy alone, in post-cardiac arrest syndrome patients: study protocol for a randomized controlled trial. ( 27484224 )
2016
18
Endothelial activation/injury and associations with severity of post-cardiac arrest syndrome and mortality after out-of-hospital cardiac arrest. ( 27523954 )
2016
19
Heart Rate and the Post Cardiac Arrest Syndrome: Another Clue to Individualizing Care? ( 26771792 )
2016
20
MIF reflects tissue damage rather than inflammation in post-cardiac arrest syndrome in a real life cohort. ( 26784134 )
2016
21
Prognostic Utility of Computed Tomography Histogram Analysis in Patients With Post-Cardiac Arrest Syndrome: Evaluation Using an Automated Whole-Brain Extraction Algorithm. ( 26953771 )
2016
22
SOFA score to assess the severity of the post-cardiac arrest syndrome. ( 26965206 )
2016
23
Letter by Chan Regarding Article, "The Utility of Therapeutic Hypothermia for Post-Cardiac Arrest Syndrome Patients With an Initial Nonshockable Rhythm". ( 27143158 )
2016
24
Response to Letter Regarding Article, "The Utility of Therapeutic Hypothermia for Post-Cardiac Arrest Syndrome Patients With an Initial Nonshockable Rhythm". ( 27143159 )
2016
25
The Utility of Therapeutic Hypothermia for Post-Cardiac Arrest Syndrome Patients With an Initial Non-Shockable Rhythm. ( 26572795 )
2015
26
Sudden Cardiac Death and Post Cardiac Arrest Syndrome. An Overview. ( 29967826 )
2015
27
Effectiveness of lower target temperature therapeutic hypothermia in post-cardiac arrest syndrome patients with a resuscitation interval of ≤30 min. ( 26097741 )
2015
28
Enterocyte Damage: A Piece in the Puzzle of Post-Cardiac Arrest Syndrome. ( 26196845 )
2015
29
Response to letter regarding article, "association between postresuscitation partial pressure of arterial carbon dioxide and neurological outcome in patients with post-cardiac arrest syndrome". ( 24396019 )
2014
30
Letter by Eastwood et Al regarding article, "association between postresuscitation partial pressure of arterial carbon dioxide and neurological outcome in patients with post-cardiac arrest syndrome". ( 24396021 )
2014
31
Association between initial prescribed minute ventilation and post-resuscitation partial pressure of arterial carbon dioxide in patients with post-cardiac arrest syndrome. ( 24602367 )
2014
32
Immature/total granulocyte ratio: a promising tool to assess the severity and the outcome of post-cardiac arrest syndrome. ( 24795281 )
2014
33
Cool hemodynamics--the intricate interplay between therapeutic hypothermia and the post-cardiac arrest syndrome. ( 24998165 )
2014
34
Estimated cerebral oxyhemoglobin as a useful indicator of neuroprotection in patients with post-cardiac arrest syndrome: a prospective, multicenter observational study. ( 25168063 )
2014
35
Survival and neurologic outcomes of out-of-hospital cardiac arrest patients who were transferred after return of spontaneous circulation for integrated post-cardiac arrest syndrome care: the another feasibility of the cardiac arrest center. ( 25246751 )
2014
36
Plasma thioredoxin levels during post-cardiac arrest syndrome: relationship with severity and outcome. ( 23356570 )
2013
37
Coagulofibrinolytic changes in patients with disseminated intravascular coagulation associated with post-cardiac arrest syndrome--fibrinolytic shutdown and insufficient activation of fibrinolysis lead to organ dysfunction. ( 23726093 )
2013
38
Serum procalcitonin as a marker of post-cardiac arrest syndrome and long-term neurological recovery, but not of early-onset infections, in comatose post-anoxic patients treated with therapeutic hypothermia. ( 23380286 )
2013
39
Association between postresuscitation partial pressure of arterial carbon dioxide and neurological outcome in patients with post-cardiac arrest syndrome. ( 23613256 )
2013
40
Therapeutic effects of Shenfu Injection on post-cardiac arrest syndrome. ( 23975138 )
2013
41
Status of systemic oxidative stress during therapeutic hypothermia in patients with post-cardiac arrest syndrome. ( 24066191 )
2013
42
EEG patterns in hypoxic encephalopathies (post-cardiac arrest syndrome): fluctuations, transitions, and reactions. ( 24084181 )
2013
43
Post-cardiac Arrest Syndrome in Children. ( 25417033 )
2013
44
Seizures and status epilepticus in post cardiac arrest syndrome: therapeutic opportunities to improve outcome or basis to withhold life sustaining therapies? ( 22513351 )
2012
45
Early findings on brain computed tomography and the prognosis of post-cardiac arrest syndrome: application of the score for stroke patients. ( 22227499 )
2012
46
Management of the post-cardiac arrest syndrome. ( 22281034 )
2012
47
Perturbation of the endothelial glycocalyx in post cardiac arrest syndrome. ( 22306259 )
2012
48
The frequency and timing of epileptiform activity on continuous electroencephalogram in comatose post-cardiac arrest syndrome patients treated with therapeutic hypothermia. ( 22366352 )
2012
49
Duration of well-controlled core temperature correlates with neurological outcome in patients with post-cardiac arrest syndrome. ( 22795997 )
2012
50
A pilot study examining the severity and outcome of the post-cardiac arrest syndrome: a comparative analysis of two geographically distinct hospitals. ( 22879369 )
2012

Variations for Post-Cardiac Arrest Syndrome

Expression for Post-Cardiac Arrest Syndrome

Search GEO for disease gene expression data for Post-Cardiac Arrest Syndrome.

Pathways for Post-Cardiac Arrest Syndrome

Pathways related to Post-Cardiac Arrest Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.5 IRAK4 PYCARD

GO Terms for Post-Cardiac Arrest Syndrome

Cellular components related to Post-Cardiac Arrest Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.5 HMGB1 IRAK3 IRAK4 PRDX4 PYCARD RBM28
2 secretory granule lumen GO:0034774 8.8 HMGB1 PRDX4 PYCARD

Biological processes related to Post-Cardiac Arrest Syndrome according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.74 HMGB1 IRAK4 PYCARD
2 neutrophil degranulation GO:0043312 9.73 HMGB1 PRDX4 PYCARD
3 positive regulation of JNK cascade GO:0046330 9.55 HMGB1 PYCARD
4 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.54 IRAK3 PYCARD
5 regulation of autophagy GO:0010506 9.52 HMGB1 PYCARD
6 positive regulation of interleukin-6 production GO:0032755 9.51 HMGB1 PYCARD
7 positive regulation of tumor necrosis factor production GO:0032760 9.49 HMGB1 PYCARD
8 interleukin-1-mediated signaling pathway GO:0070498 9.48 IRAK3 IRAK4
9 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.46 HMGB1 PYCARD
10 toll-like receptor signaling pathway GO:0002224 9.43 HMGB1 IRAK4
11 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.4 IRAK3 IRAK4
12 positive regulation of interleukin-1 beta secretion GO:0050718 9.37 HMGB1 PYCARD
13 positive regulation of activated T cell proliferation GO:0042104 9.32 HMGB1 PYCARD
14 positive regulation of interleukin-6 secretion GO:2000778 9.26 HMGB1 PYCARD
15 activation of innate immune response GO:0002218 9.16 HMGB1 PYCARD
16 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.13 IRAK3 IRAK4 PYCARD
17 myeloid dendritic cell activation GO:0001773 8.62 HMGB1 PYCARD

Sources for Post-Cardiac Arrest Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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