MCID: PST106
MIFTS: 33

Post-Cardiac Arrest Syndrome

Categories: Blood diseases, Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Post-Cardiac Arrest Syndrome

MalaCards integrated aliases for Post-Cardiac Arrest Syndrome:

Name: Post-Cardiac Arrest Syndrome 12 15
Post Cardiac Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0070306

Summaries for Post-Cardiac Arrest Syndrome

Disease Ontology : 12 A syndrome that is characterized by four main components

MalaCards based summary : Post-Cardiac Arrest Syndrome, also known as post cardiac syndrome, is related to acrocallosal syndrome and cardiac arrest. An important gene associated with Post-Cardiac Arrest Syndrome is RBM28 (RNA Binding Motif Protein 28), and among its related pathways/superpathways are AGE-RAGE signaling pathway in diabetic complications and Dendritic Cells Developmental Lineage Pathway. The drugs Clonazepam and Valproic Acid have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and heart.

Related Diseases for Post-Cardiac Arrest Syndrome

Graphical network of the top 20 diseases related to Post-Cardiac Arrest Syndrome:



Diseases related to Post-Cardiac Arrest Syndrome

Symptoms & Phenotypes for Post-Cardiac Arrest Syndrome

Drugs & Therapeutics for Post-Cardiac Arrest Syndrome

Drugs for Post-Cardiac Arrest Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
2
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
3 Kava Approved, Investigational, Nutraceutical Phase 4 9000-38-8
4 Central Nervous System Depressants Phase 4,Phase 3
5 Psychotropic Drugs Phase 4
6 GABA Agents Phase 4
7 GABA Modulators Phase 4
8 Neurotransmitter Agents Phase 4
9 Tranquilizing Agents Phase 4
10 Antimanic Agents Phase 4
11 Anticonvulsants Phase 4
12
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
13 Xenon Experimental Phase 3 7440-63-3
14 Immunologic Factors Phase 3,Not Applicable
15 Immunosuppressive Agents Phase 3
16 Dermatologic Agents Phase 3
17 Anti-Infective Agents Phase 3
18 Antifungal Agents Phase 3
19 Antirheumatic Agents Phase 3
20 Protective Agents Phase 3,Phase 2
21 Calcineurin Inhibitors Phase 3
22 Cyclosporins Phase 3
23 Anesthetics Phase 3
24 Anesthetics, General Phase 3
25 Anesthetics, Inhalation Phase 3
26
Epoprostenol Approved Phase 2 35121-78-9, 61849-14-7 5282411 5280427
27
Iloprost Approved, Investigational Phase 2 78919-13-8 6443959
28
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 2 70-16-6, 59-43-8 1130
29
Vitamin C Approved, Nutraceutical Phase 2 50-81-7 54670067 5785
30
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
31 Tezosentan Investigational Phase 2 180384-57-0
32 Platelet Aggregation Inhibitors Phase 2
33 Vasodilator Agents Phase 2
34 Antihypertensive Agents Phase 2
35 Vitamins Phase 2
36 Micronutrients Phase 2
37 Antioxidants Phase 2
38 Folate Phase 2
39 Vitamin B Complex Phase 2
40 Nutrients Phase 2
41 Trace Elements Phase 2
42 Thiamin Phase 2
43 Vitamin B9 Phase 2
44 Complement System Proteins Not Applicable

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 The Benefit of Prophylactic Anticonvulsant in Post Cardiac Arrest Syndrome With Induced Mild Hypothermia Unknown status NCT01083784 Phase 4 Use of prophylactic anticonvulsants (valproate, clonazepam);Control group
2 Trial of Different Hypothermia Temperatures in Patients Recovered From Out-of-hospital Cardiac Arrest Completed NCT01155622 Phase 4
3 Cyclosporine A in Cardiac Arrest Completed NCT01595958 Phase 3 Cyclosporine A
4 Xenon for Neuroprotection During Post-Cardiac Arrest Syndrome in Comatose Survivors of an Out of Hospital Cardiac Arrest Recruiting NCT03176186 Phase 3
5 Endothelial Dysfunction in Resuscitated Cardiac Arrest Completed NCT02685618 Phase 2 Iloprost;Saline
6 Vitamin C in Post-cardiac Arrest Not yet recruiting NCT03509662 Phase 2 Vitamin C;Thiamine;Placebos
7 The Complement Lectin Pathway After Cardiac Arrest Unknown status NCT02826057 Not Applicable
8 Bronchial Alpha Amylase as a Marker for Early Aspiration Pneumonia in Therapeutic Hypothermia. Unknown status NCT03007862
9 Bacterial Infection Diagnosis Using Blood DNA Unknown status NCT00698919
10 Study of Survivors of Different Types of Cardiac Arrest and Their Neurological Recovery Unknown status NCT02033720
11 Histones and Free-plasma DNA After Cardiac Arrest Completed NCT02733146
12 Transitions Between Clinical Circulatory States After Out-of-hospital Cardiac Arrest Completed NCT02648061
13 Hemoadsorption With CytoSorb® in Post-Cardiac Arrest Syndrome Recruiting NCT03523039 Not Applicable
14 The Effect of IABP Early Insertion on Mortality in Post Cardiac Arrest Patients With Acute Coronary Syndrome Recruiting NCT03638609 Not Applicable
15 Predicting Long-term Outcomes After Cardiac Arrest by Using Serum NGAL Recruiting NCT03615300
16 Prognostic Value of Ventricular Fibrillation Spectral Analysis in Sudden Cardiac Death Recruiting NCT03248557
17 Cerebral Oxymetry and Neurological Outcome in Therapeutic Hypothermia Recruiting NCT03024021
18 Cytokine Adsorption in Post-cardiac Arrest Syndrome in Patients Requiring Extracorporeal Cardiopulmonary Resuscitation Not yet recruiting NCT03685383 Not Applicable

Search NIH Clinical Center for Post-Cardiac Arrest Syndrome

Genetic Tests for Post-Cardiac Arrest Syndrome

Anatomical Context for Post-Cardiac Arrest Syndrome

MalaCards organs/tissues related to Post-Cardiac Arrest Syndrome:

42
Brain, Endothelial, Heart, B Cells

Publications for Post-Cardiac Arrest Syndrome

Articles related to Post-Cardiac Arrest Syndrome:

(show top 50) (show all 73)
# Title Authors Year
1
The post-cardiac arrest syndrome: A case for lung-brain coupling and opportunities for neuroprotection. ( 30866740 )
2019
2
ExtraCorporeal life support for Cardiac ARrest in patients with post cardiac arrest syndrome: The ECCAR study. ( 30612896 )
2019
3
Early Initiation of Continuous Renal Replacement Therapy Induces Fast Hypothermia and Improves Post-Cardiac Arrest Syndrome in a Porcine Model. ( 30335673 )
2018
4
Accuracy of the first interpretation of early brain CT images for predicting the prognosis of post-cardiac arrest syndrome patients at the emergency department. ( 29721320 )
2018
5
Differential effect of mild therapeutic hypothermia depending on the findings of hypoxic encephalopathy on early CT images in patients with post-cardiac arrest syndrome. ( 29698752 )
2018
6
Duration of Untreated Cardiac Arrest and Clinical Relevance of Animal Experiments: The Relationship Between the "No-Flow" Duration and the Severity of Post-Cardiac Arrest Syndrome in a Porcine Model. ( 28562475 )
2018
7
Differences in coagulofibrinolytic changes between post-cardiac arrest syndrome of cardiac causes and hypoxic insults: a pilot study. ( 29123894 )
2017
8
Systemic impact on secondary brain aggravation due to ischemia/reperfusion injury in post-cardiac arrest syndrome: a prospective observational study using high-mobility group box 1 protein. ( 28950909 )
2017
9
Oxidative stress and abnormal cholesterol metabolism in patients with post-cardiac arrest syndrome. ( 28955127 )
2017
10
Coagulofibrinolytic Changes in Patients with Post-cardiac Arrest Syndrome. ( 29034235 )
2017
11
Post-cardiac arrest syndrome: pathological processes, biomarkers and vasopressor support, and potential therapeutic targets. ( 29055751 )
2017
12
Factors Influencing the Quality of Standardized Treatment for Patients with Post-Cardiac Arrest Syndrome. ( 28765736 )
2017
13
A novel scoring system for predicting the neurologic prognosis prior to the initiation of induced hypothermia in cases of post-cardiac arrest syndrome: the CAST score. ( 28490379 )
2017
14
Fast therapeutic hypothermia prevents post-cardiac arrest syndrome through cyclophilin D-mediated mitochondrial permeability transition inhibition. ( 28492973 )
2017
15
Helium ventilation for treatment of post-cardiac arrest syndrome: A safety and feasibility study. ( 27473390 )
2016
16
Endothelial Dysfunction in Resuscitated Cardiac Arrest (ENDO-RCA): safety and efficacy of low-dose prostacyclin administration and blood pressure target in addition to standard therapy, as compared to standard therapy alone, in post-cardiac arrest syndrome patients: study protocol for a randomized controlled trial. ( 27484224 )
2016
17
Endothelial activation/injury and associations with severity of post-cardiac arrest syndrome and mortality after out-of-hospital cardiac arrest. ( 27523954 )
2016
18
Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome - First-in-Human Pilot Study. ( 27334126 )
2016
19
High-mobility group box 1 is associated with neurological outcome in patients with post-cardiac arrest syndrome after out-of-hospital cardiac arrest. ( 27247778 )
2016
20
Heart Rate and the Post Cardiac Arrest Syndrome: Another Clue to Individualizing Care? ( 26771792 )
2016
21
MIF reflects tissue damage rather than inflammation in post-cardiac arrest syndrome in a real life cohort. ( 26784134 )
2016
22
Prognostic Utility of Computed Tomography Histogram Analysis in Patients With Post-Cardiac Arrest Syndrome: Evaluation Using an Automated Whole-Brain Extraction Algorithm. ( 26953771 )
2016
23
SOFA score to assess the severity of the post-cardiac arrest syndrome. ( 26965206 )
2016
24
Letter by Chan Regarding Article, "The Utility of Therapeutic Hypothermia for Post-Cardiac Arrest Syndrome Patients With an Initial Nonshockable Rhythm". ( 27143158 )
2016
25
Response to Letter Regarding Article, "The Utility of Therapeutic Hypothermia for Post-Cardiac Arrest Syndrome Patients With an Initial Nonshockable Rhythm". ( 27143159 )
2016
26
Internal Mammary Artery Injury Related to Chest Compressions in a Patient with Post-cardiac Arrest Syndrome. ( 27181536 )
2016
27
Effectiveness of lower target temperature therapeutic hypothermia in post-cardiac arrest syndrome patients with a resuscitation interval of ≤30 min. ( 26097741 )
2015
28
Enterocyte Damage: A Piece in the Puzzle of Post-Cardiac Arrest Syndrome. ( 26196845 )
2015
29
The Utility of Therapeutic Hypothermia for Post-Cardiac Arrest Syndrome Patients With an Initial Nonshockable Rhythm. ( 26572795 )
2015
30
Sudden Cardiac Death and Post Cardiac Arrest Syndrome. An Overview. ( 29967826 )
2015
31
Response to letter regarding article, "association between postresuscitation partial pressure of arterial carbon dioxide and neurological outcome in patients with post-cardiac arrest syndrome". ( 24396019 )
2014
32
Letter by Eastwood et Al regarding article, "association between postresuscitation partial pressure of arterial carbon dioxide and neurological outcome in patients with post-cardiac arrest syndrome". ( 24396021 )
2014
33
Association between initial prescribed minute ventilation and post-resuscitation partial pressure of arterial carbon dioxide in patients with post-cardiac arrest syndrome. ( 24602367 )
2014
34
Immature/total granulocyte ratio: a promising tool to assess the severity and the outcome of post-cardiac arrest syndrome. ( 24795281 )
2014
35
Cool hemodynamics--the intricate interplay between therapeutic hypothermia and the post-cardiac arrest syndrome. ( 24998165 )
2014
36
Estimated cerebral oxyhemoglobin as a useful indicator of neuroprotection in patients with post-cardiac arrest syndrome: a prospective, multicenter observational study. ( 25168063 )
2014
37
Survival and neurologic outcomes of out-of-hospital cardiac arrest patients who were transferred after return of spontaneous circulation for integrated post-cardiac arrest syndrome care: the another feasibility of the cardiac arrest center. ( 25246751 )
2014
38
Coagulofibrinolytic changes in patients with disseminated intravascular coagulation associated with post-cardiac arrest syndrome--fibrinolytic shutdown and insufficient activation of fibrinolysis lead to organ dysfunction. ( 23726093 )
2013
39
Status of systemic oxidative stress during therapeutic hypothermia in patients with post-cardiac arrest syndrome. ( 24066191 )
2013
40
EEG patterns in hypoxic encephalopathies (post-cardiac arrest syndrome): fluctuations, transitions, and reactions. ( 24084181 )
2013
41
Plasma thioredoxin levels during post-cardiac arrest syndrome: relationship with severity and outcome. ( 23356570 )
2013
42
Serum procalcitonin as a marker of post-cardiac arrest syndrome and long-term neurological recovery, but not of early-onset infections, in comatose post-anoxic patients treated with therapeutic hypothermia. ( 23380286 )
2013
43
Association between postresuscitation partial pressure of arterial carbon dioxide and neurological outcome in patients with post-cardiac arrest syndrome. ( 23613256 )
2013
44
Therapeutic effects of Shenfu Injection on post-cardiac arrest syndrome. ( 23975138 )
2013
45
Post-cardiac Arrest Syndrome in Children. ( 25417033 )
2013
46
Early findings on brain computed tomography and the prognosis of post-cardiac arrest syndrome: application of the score for stroke patients. ( 22227499 )
2012
47
Management of the post-cardiac arrest syndrome. ( 22281034 )
2012
48
Perturbation of the endothelial glycocalyx in post cardiac arrest syndrome. ( 22306259 )
2012
49
The frequency and timing of epileptiform activity on continuous electroencephalogram in comatose post-cardiac arrest syndrome patients treated with therapeutic hypothermia. ( 22366352 )
2012
50
Seizures and status epilepticus in post cardiac arrest syndrome: therapeutic opportunities to improve outcome or basis to withhold life sustaining therapies? ( 22513351 )
2012

Variations for Post-Cardiac Arrest Syndrome

Expression for Post-Cardiac Arrest Syndrome

Search GEO for disease gene expression data for Post-Cardiac Arrest Syndrome.

Pathways for Post-Cardiac Arrest Syndrome

Pathways related to Post-Cardiac Arrest Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.26 IL6 THBD
2 11.02 IL6 THBD
3 10.64 HMGB1 IL6
4 10.15 IL6 THBD

GO Terms for Post-Cardiac Arrest Syndrome

Biological processes related to Post-Cardiac Arrest Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-6 production GO:0032755 8.96 HMGB1 IL6
2 response to glucocorticoid GO:0051384 8.85 IL6
3 response to peptidoglycan GO:0032494 8.62 IL6 IRAK3

Sources for Post-Cardiac Arrest Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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