MCID: PST106
MIFTS: 31

Post-Cardiac Arrest Syndrome

Categories: Blood diseases, Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Post-Cardiac Arrest Syndrome

MalaCards integrated aliases for Post-Cardiac Arrest Syndrome:

Name: Post-Cardiac Arrest Syndrome 12 15
Post Cardiac Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0070306

Summaries for Post-Cardiac Arrest Syndrome

Disease Ontology : 12 A syndrome that is characterized by four main components: post-cardiac arrest brain injury, post-cardiac arrest myocardial dysfunction, systemic ischemia reperfusion response, and persistent precipitating pathologies.

MalaCards based summary : Post-Cardiac Arrest Syndrome, also known as post cardiac syndrome, is related to brain injury and disseminated intravascular coagulation. An important gene associated with Post-Cardiac Arrest Syndrome is TXN (Thioredoxin), and among its related pathways/superpathways are Fluid shear stress and atherosclerosis and Cytosolic sensors of pathogen-associated DNA. The drugs Clonazepam and Valproic acid have been mentioned in the context of this disorder. Affiliated tissues include endothelial, heart and lung.

Related Diseases for Post-Cardiac Arrest Syndrome

Diseases in the Cardiac Arrest family:

Post-Cardiac Arrest Syndrome

Diseases related to Post-Cardiac Arrest Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 brain injury 30.1 S100B IL6 ENO2
2 disseminated intravascular coagulation 29.9 THBD PPIC IL6 HMGB1
3 adult respiratory distress syndrome 29.9 THBD IL6 HMGB1
4 stroke, ischemic 29.7 THBD IL6 HMGB1 ENO2
5 cardiac arrest 11.0
6 ocular motor apraxia 10.3
7 intracranial cysts 10.3 S100B ENO2
8 bednar tumor 10.3 S100B ENO2
9 meningeal melanocytoma 10.3 S100B ENO2
10 head injury 10.3 S100B ENO2
11 pineocytoma 10.3 S100B ENO2
12 akinetic mutism 10.2 S100B ENO2
13 ossifying fibromyxoid tumor 10.2 S100B ENO2
14 optic nerve glioma 10.2 S100B ENO2
15 middle cerebral artery infarction 10.2 S100B ENO2
16 subleukemic leukemia 10.2 S100B ENO2
17 acute mountain sickness 10.2 S100B ENO2
18 ovarian small cell carcinoma 10.2 S100B ENO2
19 ventricular fibrillation, paroxysmal familial, 1 10.2
20 spondylosis 10.2 S100B ENO2
21 papilloma of choroid plexus 10.2 S100B ENO2
22 acute cholangitis 10.2 THBD IL6
23 encephalomalacia 10.2 S100B IL6
24 idiopathic neutropenia 10.2 IL6 HMGB1
25 glomeruloid hemangioma 10.1 SDC1 IL6
26 olfactory neuroblastoma 10.1 S100B ENO2
27 pleural empyema 10.1 SDC1 IL6
28 granular cell tumor 10.1 S100B ENO2
29 extramedullary plasmacytoma 10.1 SDC1 IL6
30 endophthalmitis 10.1 IL6 HMGB1
31 status epilepticus 10.1
32 ischemia 10.1
33 myocardial stunning 10.1
34 48,xyyy 10.1
35 encephalopathy 10.1
36 seizure disorder 10.1
37 sertoli-leydig cell tumor 10.1 THBD ENO2
38 spherocytosis, type 5 10.1 SDC1 IL6
39 hemangiopericytoma, malignant 10.1 S100B ENO2
40 traumatic brain injury 10.1 S100B IL6 ENO2
41 asphyxia neonatorum 10.1 S100B IL6 ENO2
42 neuroma 10.1 S100B IL6 ENO2
43 endometrial disease 10.1 SDC1 IL6
44 multicentric castleman disease 10.1 SDC1 IL6
45 appendicitis 10.1 IL6 HMGB1 ENO2
46 desmoplastic small round cell tumor 10.0 THBD S100B ENO2
47 retinal detachment 10.0 IL6 HMGB1 ENO2
48 plasma protein metabolism disease 10.0 SDC1 IL6
49 castleman disease 10.0 SDC1 S100B IL6
50 subependymal giant cell astrocytoma 10.0 S100B ENO2

Graphical network of the top 20 diseases related to Post-Cardiac Arrest Syndrome:



Diseases related to Post-Cardiac Arrest Syndrome

Symptoms & Phenotypes for Post-Cardiac Arrest Syndrome

Drugs & Therapeutics for Post-Cardiac Arrest Syndrome

Drugs for Post-Cardiac Arrest Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
2
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
3 Psychotropic Drugs Phase 4
4 Anticonvulsants Phase 4
5 Neurotransmitter Agents Phase 4
6 GABA Modulators Phase 4
7
Xenon Experimental Phase 3 7440-63-3
8 Anesthetics Phase 3
9 Anesthetics, Inhalation Phase 3
10 Anesthetics, General Phase 3
11
Epoprostenol Approved Phase 2 35121-78-9, 61849-14-7 5282411 5280427
12
Iloprost Approved, Investigational Phase 2 78919-13-8 6443959
13
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
14
Vitamin C Approved, Nutraceutical Phase 2 50-81-7 5785 54670067
15
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 2 70-16-6, 59-43-8 1130
16
Tezosentan Investigational Phase 2 180384-57-0
17 Vasodilator Agents Phase 2
18 Platelet Aggregation Inhibitors Phase 2
19 Vitamin B9 Phase 2
20 Nutrients Phase 2
21 Trace Elements Phase 2
22 Micronutrients Phase 2
23 Vitamins Phase 2
24 Vitamin B Complex Phase 2
25 Folate Phase 2
26 Antioxidants Phase 2
27 Thiamin Phase 2
28 Protective Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Benefit of Prophylactic Anticonvulsant in Post Cardiac Arrest Syndrome With Induced Mild Hypothermia Unknown status NCT01083784 Phase 4 Use of prophylactic anticonvulsants (valproate, clonazepam);Control group
2 XePOHCAS - Xenon by Inhalation for Post Out of Hospital Cardiac Arrest Syndrome Unknown status NCT03176186 Phase 3
3 Safety and Efficacy of Low-dose Prostacyclin Administration and Blood Pressure Target in Addition to Standard Therapy, as Compared to Standard Therapy Alone, in Post-cardiac-arrest-syndrome Patients - a Randomized, Controlled, Double-blinded Investigator-initiated Trial. Completed NCT02685618 Phase 2 Iloprost;Saline
4 Early High-dose Vitamin C in Post-cardiac Arrest Syndrome Recruiting NCT03509662 Phase 2 Vitamin C;Thiamine;Placebos
5 The Effect of Intra Aortic Balloon Pump Early Insertion on Mortality in Post Cardiac Arrest Patients With Acute Coronary Syndrome Unknown status NCT03638609
6 The Effect of Cerebral Oxymetry in Determining Neurological Outcome in Patients Treated With Therapeutic Hypothermia Completed NCT03024021
7 Cytokine Adsorption in Post-cardiac Arrest Syndrome in Patients Requiring Extracorporeal Cardiopulmonary Resuscitation Completed NCT03685383
8 Early Prognostic Value of an Algorithm Based on Spectral Variables of Ventricular fibrillAtion From the EKG of Patients With suddEn Cardiac Death: a Multicenter Observational Trial Recruiting NCT03248557
9 Hemoadsorption With CytoSorb® in Post-Cardiac Arrest Syndrome: a Pilot Study (The CATCH Trial: Post Cardiac Arrest Therapy With Cytosorb Hemoadsorption) Recruiting NCT03523039
10 Intensive Care Unit Management After Cardiac ARrest in Russia. - a Retrospective Observational Multi-center Cohort Study Not yet recruiting NCT04608825

Search NIH Clinical Center for Post-Cardiac Arrest Syndrome

Genetic Tests for Post-Cardiac Arrest Syndrome

Anatomical Context for Post-Cardiac Arrest Syndrome

MalaCards organs/tissues related to Post-Cardiac Arrest Syndrome:

40
Endothelial, Heart, Lung, Adrenal Gland, Monocytes, Neutrophil

Publications for Post-Cardiac Arrest Syndrome

Articles related to Post-Cardiac Arrest Syndrome:

(show top 50) (show all 216)
# Title Authors PMID Year
1
European Resuscitation Council and European Society of Intensive Care Medicine Guidelines 2021: Post-resuscitation care. 61
33773827 2021
2
European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care. 61
33765189 2021
3
Levosimendan Ameliorates Post-Resuscitation Acute Intestinal Microcirculation Dysfunction Partly Independent of Its Effects on Systemic Circulation: A Pilot Study On Cardiac Arrest In A Rat Model. 61
33710108 2021
4
Treatment Effects of Interleukin-6 Receptor Antibodies for Modulating the Systemic Inflammatory Response After Out-of-Hospital Cardiac Arrest (The IMICA Trial): A Double-Blinded, Placebo-Controlled, Single-Center, Randomized Clinical Trial. 61
33745292 2021
5
Effects of 9-t-butyl doxycycline on the innate immune response to CNS ischemia-reperfusion injury. 61
33385413 2021
6
Pilot analysis of the usefulness of mortality risk score systems at resuscitated patients 61
33423023 2021
7
Ultrafast Hypothermia Selectively Mitigates the Early Humoral Response After Cardiac Arrest. 61
33198571 2020
8
Post-Cardiac Arrest Syndrome. 61
33313705 2020
9
Pathophysiology and clinical consequences of arterial blood gases and pH after cardiac arrest. 61
33336311 2020
10
Protective effects of therapeutic hypothermia on renal injury in an asphyxial cardiac arrest rat model. 61
33293002 2020
11
Endothelial BMP4 Promotes Leukocyte Rolling and Adhesion and Is Elevated in Patients After Survived Out-of-Hospital Cardiac Arrest. 61
32803667 2020
12
The complement lectin pathway protein MAp19 and out-of-hospital cardiac arrest: Insights from two randomized clinical trials. 61
31538810 2020
13
Vitamin C levels amongst initial survivors of out of hospital cardiac arrest. 61
32946985 2020
14
Acute respiratory failure and inflammatory response after out-of-hospital cardiac arrest: results of the Post-Cardiac Arrest Syndrome (PCAS) pilot study. 61
32004080 2020
15
Interleukin-6 Receptor Antibodies for Modulating the Systemic Inflammatory Response after Out-of-Hospital Cardiac Arrest (IMICA): study protocol for a double-blinded, placebo-controlled, single-center, randomized clinical trial. 61
33081828 2020
16
Comprehensive Cardiac Care After Cardiac Arrest. 61
32892828 2020
17
Monocyte subsets predict mortality after cardiac arrest. 61
33020969 2020
18
The association between post-cardiac arrest cerebral oxygenation and survival with favorable neurological outcomes: A multicenter study. 61
32544414 2020
19
The Sequential Organ Failure Assessment (SOFA) score predicts mortality and neurological outcome in patients with post-cardiac arrest syndrome. 61
32305260 2020
20
Hydrogen gas inhalation alleviates oxidative stress in patients with post-cardiac arrest syndrome. 61
33041520 2020
21
How to carry out and interpret EEG recordings in COVID-19 patients in ICU? 61
32405259 2020
22
Inter-Hospital Transfer after Return of Spontaneous Circulation Shows no Correlation with Neurological Outcomes in Cardiac Arrest Patients Undergoing Targeted Temperature Management in Cardiac Arrest Centers. 61
32599840 2020
23
Nitric Oxide in Post-cardiac Arrest Syndrome. 61
32421275 2020
24
Imbalance between plasma double-stranded DNA and deoxyribonuclease activity predicts mortality after out-of-hospital cardiac arrest. 61
32251701 2020
25
Somatosensory Evoked Potentials and Neuroprognostication After Cardiac Arrest. 61
31907802 2020
26
Determinants of outcomes for acute encephalopathy with reduced subcortical diffusion. 61
32499614 2020
27
Copeptin as a marker of outcome after cardiac arrest: a sub-study of the TTM trial. 61
32345356 2020
28
Dynamic determination of functional liver capacity with the LiMAx test in post-cardiac arrest patients undergoing targeted temperature management-A prospective trial. 61
31828754 2020
29
High plasma levels of pro-inflammatory factors interleukin-17 and interleukin-23 are associated with poor outcome of cardiac-arrest patients: a single center experience. 61
32293300 2020
30
The Role of Inflammatory Cytokines in Cardiac Arrest. 61
30526209 2020
31
Inhaled Gases as Therapies for Post-Cardiac Arrest Syndrome: A Narrative Review of Recent Developments. 61
33585501 2020
32
"Endothelial Dysfunction in Resuscitated Cardiac Arrest (ENDO-RCA): Safety and efficacy of low-dose Iloprost, a prostacyclin analogue, in addition to standard therapy, as compared to standard therapy alone, in post-cardiac-arrest-syndrome patients." 61
31710844 2020
33
Therapeutic strategies for ischemia reperfusion injury in emergency medicine. 61
32431842 2020
34
The Relationship Between Hematological Parameters and Mortality in Cardiovascular Patients With Postcardiac Arrest Syndrome. 61
32025402 2019
35
Effect of mild hypothermia on lung injury after cardiac arrest in swine based on lung ultrasound. 61
31690318 2019
36
[Target temperature in post-cardiac-arrest complex intensive care: arguments for mild therapeutic hypothermia]. 61
31707816 2019
37
Elimination of glutamate using CRRT for 72 h in patients with post-cardiac arrest syndrome: A randomized clinical pilot trial. 61
31557520 2019
38
Prognostic value of 18F-FDG brain PET as an early indicator of neurological outcomes in a rat model of post-cardiac arrest syndrome. 61
31616019 2019
39
Early Initiation of Continuous Renal Replacement Therapy Induces Fast Hypothermia and Improves Post-Cardiac Arrest Syndrome in a Porcine Model. 61
30335673 2019
40
Cardiac output, heart rate and stroke volume during targeted temperature management after out-of-hospital cardiac arrest: Association with mortality and cause of death. 61
31362081 2019
41
Management of post-cardiac arrest syndrome. 61
31723926 2019
42
Disseminated intravascular coagulation in cardiac arrest and resuscitation. 61
31102491 2019
43
Pediatric Post-Cardiac Arrest Care: A Scientific Statement From the American Heart Association. 61
31242751 2019
44
External validation of a risk classification at the emergency department of post-cardiac arrest syndrome patients undergoing targeted temperature management. 61
31153943 2019
45
Postresuscitation Care after Out-of-hospital Cardiac Arrest: Clinical Update and Focus on Targeted Temperature Management. 61
31021845 2019
46
[A case of post-cardiac arrest syndrome presenting with lateralized periodic discharges evolving to a cyclic seizure pattern on electroencephalogram]. 61
31243246 2019
47
The post-cardiac arrest syndrome: A case for lung-brain coupling and opportunities for neuroprotection. 61
30866740 2019
48
Bilateral internal mammary artery laceration after cardiac pulmonary resuscitation. 61
30884133 2019
49
Procalcitonin as a prognostic marker for outcomes in post-cardiac arrest patients: A systematic review and meta-analysis. 61
30872069 2019
50
Repetitive anodal transcranial direct current stimulation improves neurological outcome and survival in a ventricular fibrillation cardiac arrest rat model. 61
30611705 2019

Variations for Post-Cardiac Arrest Syndrome

Expression for Post-Cardiac Arrest Syndrome

Search GEO for disease gene expression data for Post-Cardiac Arrest Syndrome.

Pathways for Post-Cardiac Arrest Syndrome

GO Terms for Post-Cardiac Arrest Syndrome

Biological processes related to Post-Cardiac Arrest Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA binding GO:0043388 8.96 TXN HMGB1
2 response to glucocorticoid GO:0051384 8.8 SDC1 IL6 HMGB1

Molecular functions related to Post-Cardiac Arrest Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RAGE receptor binding GO:0050786 8.62 S100B HMGB1

Sources for Post-Cardiac Arrest Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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