MCID: PST095
MIFTS: 51

Post-Thrombotic Syndrome

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Post-Thrombotic Syndrome

MalaCards integrated aliases for Post-Thrombotic Syndrome:

Name: Post-Thrombotic Syndrome 12 15
Postphlebitic Syndrome 12 55 44 73
Postphlebetic Syndrome with Ulcer and Inflammation 12
Postphlebetic Syndrome with Inflammation 12
Postphlebetic Syndrome with Ulcer 12
Postthrombotic Syndrome 73
Venous Stress Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2364
ICD10 33 I87.0
ICD9CM 35 459.1
MeSH 44 D011186
SNOMED-CT 68 20427003

Summaries for Post-Thrombotic Syndrome

Disease Ontology : 12 A venous insufficiency that is characterized by aching pain, heaviness, swelling, cramps, itching, or tingling in the affected limb and is a chronic complication of deep venous thrombosis.

MalaCards based summary : Post-Thrombotic Syndrome, also known as postphlebitic syndrome, is related to chronic venous insufficiency and thrombosis. An important gene associated with Post-Thrombotic Syndrome is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Toll-like Receptor Signaling Pathway. The drugs Heparin and Dalteparin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, liver and bone, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 76 Post-thrombotic syndrome (PTS), also called postphlebitic syndrome and venous stress disorder is a... more...

Related Diseases for Post-Thrombotic Syndrome

Diseases related to Post-Thrombotic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 231)
# Related Disease Score Top Affiliating Genes
1 chronic venous insufficiency 32.1 ICAM1 SERPINE1
2 thrombosis 30.6 F2 F5 F8 SERPINC1 SERPINE1
3 thrombophilia due to thrombin defect 30.3 F2 F5 F8 SERPINC1 SERPINE1
4 varicose veins 29.9 F2 F5 SERPINC1
5 venous insufficiency 29.8 F2 ICAM1 SERPINE1
6 pulmonary embolism 29.7 F2 F5 SERPINC1 SERPINE1
7 thrombophilia 29.6 F2 F5 F8 SERPINC1 SERPINE1
8 thrombophlebitis 29.1 F2 F5 F8 SERPINC1 SERPINE1
9 vascular disease 28.7 CCL2 F2 F5 IL6 SERPINC1 SERPINE1
10 plasmodium vivax malaria 10.2 ICAM1 IL6
11 nodular goiter 10.2 ICAM1 IL6
12 arteriosclerosis obliterans 10.2 ICAM1 IL6
13 acute respiratory distress syndrome 10.2 F5 IL6
14 exanthem 10.2 IL6 TLR9
15 autoimmune disease of eyes, ear, nose and throat 10.2 IL6 TLR9
16 meningoencephalitis 10.2 IL6 TLR9
17 keratoconjunctivitis sicca 10.2 IL6 TLR9
18 lacrimal apparatus disease 10.2 IL6 TLR9
19 middle ear disease 10.2 IL6 TLR9
20 mature b-cell neoplasm 10.2 IL6 TLR9
21 collagen disease 10.2 IL6 TLR9
22 perinatal necrotizing enterocolitis 10.2 IL6 TLR9
23 lymph node disease 10.2 IL6 TLR9
24 nasal cavity disease 10.2 ICAM1 TLR9
25 factor vii deficiency 10.2 F2 F8
26 lichen disease 10.2 ICAM1 TLR9
27 compartment syndrome 10.2 F2 F8
28 acquired hemophilia 10.2 F5 F8
29 acquired hemophilia a 10.2 F5 F8
30 angina pectoris 10.2 IL6 SERPINC1
31 hemophilia a 10.2 F5 F8
32 intermediate coronary syndrome 10.2 IL6 SERPINC1
33 factor v and factor viii, combined deficiency of, 2 10.2 F5 F8
34 hemophilia 10.2 F2 F8
35 factor xii deficiency 10.2 F5 SERPINC1
36 acute liver failure 10.2 F2 F5
37 thrombasthenia 10.2 F2 F5
38 eye lymphoma 10.2 IL6 TLR9
39 autoimmune disease of urogenital tract 10.1 F2 TLR9
40 arteritic anterior ischemic optic neuropathy 10.1 F2 F5
41 paracetamol poisoning 10.1 F2 F5
42 autoimmune glomerulonephritis 10.1 ICAM1 TLR9
43 factor xi deficiency 10.1 F2 SERPINC1
44 brachydactyly, type d 10.1 F2 F8
45 viral pneumonia 10.1 IL6 TLR9
46 branch retinal artery occlusion 10.1 F2 SERPINC1
47 alcohol-related birth defect 10.1 F2 F8
48 hypersplenism 10.1 F2 SERPINC1
49 vitamin k deficiency hemorrhagic disease 10.1 F2 F8
50 von willebrand disease, type 1 10.1 F2 F8

Comorbidity relations with Post-Thrombotic Syndrome via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease
Hypertension, Essential Ischemic Heart Disease
Peripheral Vascular Disease Venous Insufficiency

Graphical network of the top 20 diseases related to Post-Thrombotic Syndrome:



Diseases related to Post-Thrombotic Syndrome

Symptoms & Phenotypes for Post-Thrombotic Syndrome

MGI Mouse Phenotypes related to Post-Thrombotic Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 F2 F5 ICAM1 IL6 SERPINC1 SERPINE1
2 hematopoietic system MP:0005397 9.8 F2 F8 ICAM1 IL6 SERPINC1 SERPINE1
3 homeostasis/metabolism MP:0005376 9.76 F2 F5 F8 ICAM1 IL6 SERPINC1
4 immune system MP:0005387 9.56 CCL2 F2 F8 ICAM1 IL6 SERPINC1
5 mortality/aging MP:0010768 9.23 F2 F5 F8 ICAM1 IL6 SERPINC1

Drugs & Therapeutics for Post-Thrombotic Syndrome

Drugs for Post-Thrombotic Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 9005-49-6 772 46507594
2
Dalteparin Approved Phase 4,Phase 3,Phase 1,Not Applicable 9005-49-6
3
Enoxaparin Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 9005-49-6 772
4
Rivaroxaban Approved Phase 4,Not Applicable 366789-02-8
5
Apixaban Approved Phase 4,Not Applicable 503612-47-3 10182969
6
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
7
Serine Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 56-45-1 5951
8 Fibrinolytic Agents Phase 4,Phase 3,Phase 1,Not Applicable
9 calcium heparin Phase 4,Phase 3,Phase 1,Not Applicable
10 Heparin, Low-Molecular-Weight Phase 4,Phase 3,Phase 1,Not Applicable
11 Anticoagulants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 Factor Xa Inhibitors Phase 4,Phase 3,Not Applicable
13 Serine Proteinase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
14 Antithrombin III Phase 4,Phase 3,Phase 2,Not Applicable
15 Antithrombins Phase 4,Phase 3,Phase 2,Not Applicable
16
protease inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
17 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
18 Hemostatics Phase 4
19 Fibrin fragment D Phase 4
20 Antifibrinolytic Agents Phase 4
21 Coagulants Phase 4
22 Antimetabolites Phase 4,Phase 2,Phase 1
23 Hypolipidemic Agents Phase 4,Phase 2,Phase 1
24 Lipid Regulating Agents Phase 4,Phase 2,Phase 1
25 Hypoglycemic Agents Phase 4
26 Glucuronyl glucosamine glycan sulfate Phase 4
27
Warfarin Approved Phase 3,Phase 1,Phase 2,Not Applicable 81-81-2 6691 54678486
28
Tinzaparin Approved Phase 3 9005-49-6, 9041-08-1 25244225
29
Nadroparin Approved, Investigational Phase 3
30
Benzocaine Approved, Investigational Phase 3,Not Applicable 94-09-7, 1994-09-7 2337
31 tannic acid Approved Phase 3,Not Applicable
32
Phytonadione Approved, Investigational Phase 3 84-80-0 4812 5284607
33
Tenecteplase Approved Phase 3 191588-94-0
34 Kava Approved, Investigational, Nutraceutical Phase 3 9000-38-8
35
Menadione Approved, Nutraceutical Phase 3 58-27-5 4055
36 Calcium, Dietary Phase 3,Phase 2,Phase 1,Not Applicable
37 Tissue Plasminogen Activator Phase 3,Not Applicable
38 Plasminogen Phase 3
39 Dabigatran Phase 3,Phase 2,Not Applicable
40 Vitamin K Phase 3
41 Vitamins Phase 3
42 naphthoquinone Phase 3
43 Menaquinone Phase 3
44 Antibodies Phase 3
45 Immunologic Factors Phase 3
46 Antibodies, Antiphospholipid Phase 3
47 Immunoglobulins Phase 3
48 Rosuvastatin Calcium Phase 2 147098-20-2
49 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2,Phase 1
50 Anticholesteremic Agents Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 82)
# Name Status NCT ID Phase Drugs
1 Outcome of Percutaneous Mechanical Thrombectomy to Treat Acute Deep Venous Thrombosis Unknown status NCT02959801 Phase 4
2 Two Weeks of Low Molecular Weight Heparin for Distal Vein Thrombosis Unknown status NCT01252420 Phase 4 Enoxaparin
3 Practicability of Gliding Aids for Medical Compression Stockings Completed NCT01432795 Phase 4
4 Apixaban for Extended Anticoagulation (APIDULCIS) Recruiting NCT03678506 Phase 4 Apixaban
5 Apixaban for Routine Management of Upper Extremity Deep Venous Thrombosis Recruiting NCT02945280 Phase 4 apixaban
6 Rivaroxaban With Diosmine in Long-term Treatment of DVT Active, not recruiting NCT03413618 Phase 4 Rivaroxaban;Diosmin
7 Prospective Evaluation of the QoL of Patients With PTS Who Receive Compression Therapy and Sulodexide Terminated NCT02512601 Phase 4 Sulodexide
8 Treatment Trial for Post-Thrombotic Syndrome Unknown status NCT00633971 Phase 3
9 The SOX Trial: Compression Stockings to Prevent the Post-Thrombotic Syndrome Completed NCT00143598 Phase 3
10 Evaluation of a Venous-Return Assist Device (Venowave) to Treat Post-Thrombotic Syndrome: A Randomized Controlled Trial Completed NCT00182208 Phase 3
11 Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis Completed NCT00790335 Phase 3 Recombinant tissue plasminogen activator (rt-PA)
12 Full-Leg vs Below-Knee Elastic Stockings for Prevention of the Post-Thrombotic Syndrome Completed NCT00426075 Phase 3
13 Randomized Controlled Trial of Anticoagulation vs. Placebo for a First Symptomatic Isolated Distal Deep-vein Thrombosis (IDDVT) Completed NCT00421538 Phase 3 nadroparine calcium;Placebo
14 Evaluation of Long-Term Sequelae After Thrombophlebitis, i.e. Deep Venous Thrombosis of the Lower Extremities Completed NCT00628576 Phase 3 unfractionated heparin;Tinzaparin (Leo)
15 DUTCH CAVA-trial: CAtheter Versus Anticoagulation Alone for Acute Primary (Ilio)Femoral DVT. Recruiting NCT00970619 Phase 3
16 Evaluation of the Duration of Therapy for Thrombosis in Children Recruiting NCT00687882 Phase 3
17 Safety of Dabigatran Etexilate in Blood Clot Prevention in Children Recruiting NCT02197416 Phase 3 dabigatran etexilate
18 EVENT: Hydrotherapy and Deep Venous Thrombosis Terminated NCT00348907 Phase 3 thermal cure;late thermal cure
19 Clot Dissolving Treatment for Blood Clots in the Lungs Terminated NCT00680628 Phase 3 Tenecteplase + Enoxaparin;0.9% Saline + Enoxaparin
20 Pediatric High-Risk Deep Venous Thrombosis Lytic Outcomes Trial Withdrawn NCT02767232 Phase 3 Recombinant tissue plasminogen activator (rt-PA);Standard Anticoagulation Therapy
21 Efficacy of Sodium Heparin in Prophylaxis of Venous Thromboembolism in Surgical Patients Withdrawn NCT00912483 Phase 3
22 Enoxaparin in Children With Asymptomatic Venous Thrombosis After Pediatric Cardiac Surgery Withdrawn NCT01474902 Phase 3 Enoxaparin
23 The Use of Intermittent Pneumatic Compression Device for Symptomatic Relief in Patients With Post Thrombotic Syndrome Unknown status NCT01637428 Phase 2
24 Laparoscopic Bariatric Surgery: Two Regimens of Venous Thromboprophylaxis: Prospective Randomized Study Unknown status NCT02128178 Phase 1, Phase 2 Enoxaparin 40 mg 2 hours before arm;Enoxaparin 40 mg 12 hours before arm
25 Safety and Tolerability of Dabigatran Etexilate in Adolescents Completed NCT00844415 Phase 2 dabigatran etexilate
26 StAtins for Venous Event Reduction in Patients With Venous Thromboembolism Pilot Study Recruiting NCT02679664 Phase 2 Rosuvastatin
27 Statin Use in Patients With Acute VTE Recruiting NCT02331095 Phase 1, Phase 2 Atorvastatin;Warfarin
28 Single Session Percutaneous Mechanical Thrombectomy for the Treatment of Ilio-femoral Deep Vein Thrombosis: A Preliminary Evaluation Terminated NCT02066597 Phase 2
29 Twice Daily Enoxaparin Prophylaxis in Reconstructive Surgery Patients Completed NCT02687204 Phase 1 Twice daily enoxaparin prophylaxis;Real time dose adjustment
30 Aqua Therapy in Deep Venous Thrombosis and Insufficiency Unknown status NCT02553720 Not Applicable
31 Global Anticoagulant Registry in the FIELD- Venous Thromboembolic Events Unknown status NCT02155491
32 Observational Prospectif Monocentric Registry of Patients Suffering From VIE Unknown status NCT02188056
33 Prevention of Recurrence After Thrombolysis in Acute Iliofemoral Venous Thrombosis (PRAIS) Study Unknown status NCT01986192 Not Applicable rivaroxaban;Warfarin
34 REVITIVE for the Treatment of Patients With Venous Insufficiency Unknown status NCT02114307 Not Applicable
35 Study of a Novel Thrombectomy Device to Treat Acute Iliofemoral Deep Venous Thrombosis Unknown status NCT02414802 Not Applicable low-molecular-weight heparin calcium;urokinase
36 Biomarkers in Post Thrombotic Syndrome Completed NCT02376764
37 Post Thrombotic Syndrome Prevention Study Completed NCT03039517 Not Applicable
38 The Ideal Deep Venous Thrombosis (DVT) Study Completed NCT01429714 Not Applicable
39 Pilot Study for VeinoPlus to Improve Symptoms of Postthrombotic Syndrome (PTS) Completed NCT00858130 Not Applicable
40 Biomarker Sub Study of the Compression Stockings to Prevent the Post-Thrombotic Syndrome (SOX) Trial Completed NCT01615705
41 Evaluating the Relationship Between Blood Clotting Disorders, Inflammation, and Obesity in Individuals With Venous Disorders and Post-Thrombotic Syndrome Completed NCT00395265
42 Substudy - Evaluation of Patients With Iliac Vein Thrombosis Completed NCT03148548
43 Feasibility Study of Exercise in Patients With Leg Blood Clots Completed NCT00910364 Not Applicable
44 Ultrasound-enhanced Thrombolysis Versus Standard Catheter Directed Thrombolysis for Ilio-femoral Deep Vein Thrombosis Completed NCT01482273 Not Applicable
45 Catheter-Directed Venous Thrombolysis in Acute Iliofemoral Vein Thrombosis Completed NCT00251771 Not Applicable
46 Treadmill Pilot Study (Invasive Pressure Measurements in PTS) Completed NCT01846780
47 Ultrasound Elasticity Imaging of Venous Thrombi Completed NCT00726947 Early Phase 1
48 Evaluation of Patients With Vena Cava Inferior Thrombosis Completed NCT00631423
49 The Swiss Venous Thromboembolism Cohort 65+ Completed NCT00973596
50 Clinical Assessment of Thrombosis in Children After Heart Surgery Completed NCT01435473

Search NIH Clinical Center for Post-Thrombotic Syndrome

Cochrane evidence based reviews: postphlebitic syndrome

Genetic Tests for Post-Thrombotic Syndrome

Anatomical Context for Post-Thrombotic Syndrome

MalaCards organs/tissues related to Post-Thrombotic Syndrome:

41
Endothelial, Liver, Bone, Heart, Lymph Node, Eye, Spinal Cord

Publications for Post-Thrombotic Syndrome

Articles related to Post-Thrombotic Syndrome:

(show top 50) (show all 340)
# Title Authors Year
1
Predicting Post-Thrombotic Syndrome with Ultrasonographic Follow-Up after Deep Vein Thrombosis: A Systematic Review and Meta-Analysis. ( 29972864 )
2018
2
Prevention of recurrent venous thrombosis and post-thrombotic syndrome. ( 29795059 )
2018
3
Individualised versus standard duration of elastic compression therapy for prevention of post-thrombotic syndrome (IDEAL DVT): a multicentre, randomised, single-blind, allocation-concealed, non-inferiority trial. ( 29217387 )
2018
4
Stockings to prevent post-thrombotic syndrome-where are we now? ( 29304324 )
2018
5
ABO blood group and the risk of post-thrombotic syndrome. ( 29387976 )
2018
6
Rivaroxaban versus warfarin for the prevention of post-thrombotic syndrome. ( 29324334 )
2018
7
Elevated leptin and decreased adiponectin independently predict the post-thrombotic syndrome in obese and non-obese patients. ( 29720688 )
2018
8
Treatment of Femoral Vein Obstruction Concomitant with Iliofemoral Stenting in Patients with Severe Post-thrombotic Syndrome. ( 29292209 )
2018
9
Development and Validation of a Practical Two-Step Prediction Model and Clinical Risk Score for Post-Thrombotic Syndrome. ( 29864783 )
2018
10
Iliofemoral deep vein thrombosis and the problem of post-thrombotic syndrome. ( 29882562 )
2018
11
Rivaroxaban Versus Warfarin and Risk of Post-Thrombotic Syndrome Among Patients with Venous Thromboembolism. ( 29476744 )
2018
12
A Summation Analysis of Compliance and Complications of Compression Hosiery for Patients with Chronic Venous Disease or Post-thrombotic Syndrome. ( 29329662 )
2018
13
Post-thrombotic syndrome in children. ( 28811041 )
2018
14
Derivation and Validation of a Prediction Model for Risk Stratification of Post-Thrombotic Syndrome in Elderly Patients with a First Deep Vein Thrombosis. ( 29960276 )
2018
15
Beneficial Effect of Endovascular Treatment on Villalta Score in Japanese Patients With Chronic Iliofemoral Venous Thrombosis and Post-Thrombotic Syndrome. ( 30033947 )
2018
16
Prevention and treatment of the post-thrombotic syndrome. ( 30046723 )
2018
17
Characteristics of pain, other symptoms and function in pediatric post-thrombotic syndrome. ( 30046736 )
2018
18
Assessment of limb edema in pediatric post-thrombotic syndrome. ( 30046764 )
2018
19
Predicting the Post-Thrombotic Syndrome: Not Quite Ready for Prime Time. ( 30060253 )
2018
20
Assessment of the Probability of Post-thrombotic Syndrome in Patients with Lower Extremity Deep Venous Thrombosis. ( 30139989 )
2018
21
Electrical calf muscle stimulation in patients with post-thrombotic syndrome and residual venous obstruction after anticoagulation therapy. ( 30160082 )
2018
22
Risk factors for post-thrombotic syndrome in patients with deep vein thrombosis: from the COMMAND VTE registry. ( 30293163 )
2018
23
Elastic compression therapy to prevent post-thrombotic syndrome. ( 30314711 )
2018
24
Individually shortened duration versus standard duration of elastic compression therapy for prevention of post-thrombotic syndrome: a cost-effectiveness analysis. ( 30314712 )
2018
25
Rutosides for prevention of post-thrombotic syndrome. ( 30406639 )
2018
26
Rutosides for treatment of post-thrombotic syndrome. ( 30406640 )
2018
27
Venous Thrombosis and Post-Thrombotic Syndrome: From Novel Biomarkers to Biology. ( 30410646 )
2018
28
Systematic Review and Meta-Analysis of Iliofemoral Stenting for Post-thrombotic Syndrome. ( 30414801 )
2018
29
Treatment of DVT with rivaroxaban and its potential to prevent the post-thrombotic syndrome. ( 30465419 )
2018
30
Acute thrombosis of the azygos vein and severe post-thrombotic syndrome of superior vena cava. ( 30470443 )
2018
31
Incidence and Risk Factors for Post-Thrombotic Syndrome in Patients With Deep Vein Thrombosis Following Total Knee and Hip Arthroplasty. ( 30503320 )
2018
32
Characterization of Post-Thrombotic Syndrome in Children with Cardiac Disease. ( 30528575 )
2018
33
Post-thrombotic syndrome and recurrent thromboembolism in patients with upper extremity deep vein thrombosis: A systematic review and meta-analysis. ( 30553163 )
2018
34
Endophlebectomy of the common femoral vein and arteriovenous fistula creation as adjuncts to venous stenting for post-thrombotic syndrome. ( 28221670 )
2017
35
Post thrombotic syndrome following deep vein thrombosis in paediatric patients. ( 28121229 )
2017
36
Diagnostic scales for the post-thrombotic syndrome. ( 29126608 )
2017
37
Compression therapy for prevention of post-thrombotic syndrome. ( 28950030 )
2017
38
Prevention and treatment of the post-thrombotic syndrome. ( 28736157 )
2017
39
Rivaroxaban versus warfarin in the prevention of post-thrombotic syndrome. ( 28692839 )
2017
40
Epidemiology of the post-thrombotic syndrome. ( 28844444 )
2017
41
The importance of post thrombotic syndrome as an outcome after deep venous thrombosis: A survey of Canadian thrombosis clinicians. ( 28942356 )
2017
42
Two divergent paths: compression vs. non-compression in deep venous thrombosis and post thrombotic syndrome. ( 29930664 )
2017
43
Toll-like receptor 9 gene expression in the post-thrombotic syndrome, residual thrombosis and recurrent deep venous thrombosis: A case-control study. ( 26938157 )
2016
44
Clot structure and fibrinolytic potential in patients with post thrombotic syndrome. ( 26589270 )
2016
45
Post-thrombotic syndrome and venous disease-specific quality of life in patients with vascular BehAset's disease. ( 27318049 )
2016
46
Predictors of the post-thrombotic syndrome and their effect on the therapeutic management of deep vein thrombosis. ( 27639012 )
2016
47
Time taken to the maximum increase in the oxygenated hemoglobin level in calf muscle as a predictor of mild and moderate post-thrombotic syndrome. ( 27638999 )
2016
48
Stockings to prevent post-thrombotic syndrome. ( 27245828 )
2016
49
Efficacy of compression for the prevention of post-thrombotic syndrome: an unsolved clinical conundrum Comment on Burgstaller et al, p. 141 - 147. ( 27058794 )
2016
50
Post-thrombotic syndrome in patients treated with rivaroxaban or enoxaparin/vitamin K antagonists for acute deep-vein thrombosis. A post-hoc analysis. ( 27583311 )
2016

Variations for Post-Thrombotic Syndrome

Expression for Post-Thrombotic Syndrome

Search GEO for disease gene expression data for Post-Thrombotic Syndrome.

Pathways for Post-Thrombotic Syndrome

Pathways related to Post-Thrombotic Syndrome according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.03 F2 F5 F8 SERPINC1 SERPINE1
2
Show member pathways
12.74 CCL2 IL6 SERPINE1 TLR9
3
Show member pathways
12.57 F2 F5 F8 SERPINC1
4
Show member pathways
12.53 CCL2 ICAM1 IL6 TLR9
5
Show member pathways
11.99 CCL2 F2 ICAM1 IL6 SERPINE1
6
Show member pathways
11.97 CCL2 F2 ICAM1 TLR9
7 11.77 CCL2 ICAM1 IL6
8 11.73 CCL2 ICAM1 IL6
9 11.69 CCL2 ICAM1 IL6
10 11.62 CCL2 ICAM1 IL6 SERPINE1
11 11.59 CCL2 ICAM1 IL6
12
Show member pathways
11.56 F2 F5 F8 SERPINC1 SERPINE1
13 11.3 CCL2 ICAM1 IL6
14 11.16 F2 F5 F8 SERPINC1 SERPINE1
15 11.15 CCL2 ICAM1 IL6 TLR9
16 11.12 ICAM1 IL6 TLR9
17 11.11 CCL2 IL6
18 10.94 CCL2 F2 ICAM1
19 10.73 CCL2 ICAM1

GO Terms for Post-Thrombotic Syndrome

Cellular components related to Post-Thrombotic Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 CCL2 F2 F5 F8 IL6 SERPINC1
2 platelet alpha granule lumen GO:0031093 9.43 F5 F8 SERPINE1
3 endoplasmic reticulum lumen GO:0005788 9.35 F2 F5 F8 IL6 SERPINC1
4 extracellular space GO:0005615 9.23 CCL2 F2 F5 F8 ICAM1 IL6

Biological processes related to Post-Thrombotic Syndrome according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.84 CCL2 F2 IL6 SERPINE1
2 ER to Golgi vesicle-mediated transport GO:0006888 9.77 F2 F5 F8
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.73 ICAM1 IL6 TLR9
4 regulation of cell shape GO:0008360 9.72 CCL2 F2 ICAM1
5 platelet degranulation GO:0002576 9.65 F5 F8 SERPINE1
6 platelet activation GO:0030168 9.63 F2 F8 IL6
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.62 ICAM1 SERPINE1
8 cellular protein metabolic process GO:0044267 9.62 F2 F5 IL6 SERPINC1
9 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.61 ICAM1 SERPINE1
10 positive regulation of interleukin-8 production GO:0032757 9.61 SERPINE1 TLR9
11 positive regulation of JAK-STAT cascade GO:0046427 9.59 F2 IL6
12 fibrinolysis GO:0042730 9.58 F2 SERPINE1
13 positive regulation of chemokine production GO:0032722 9.58 IL6 TLR9
14 blood coagulation, intrinsic pathway GO:0007597 9.57 F2 F8
15 blood coagulation GO:0007596 9.56 F2 F5 F8 SERPINC1
16 defense response to Gram-negative bacterium GO:0050829 9.54 IL6 SERPINE1 TLR9
17 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.52 CCL2 TLR9
18 positive regulation of blood coagulation GO:0030194 9.51 F2 SERPINE1
19 regulation of blood coagulation GO:0030193 9.49 F2 SERPINC1
20 negative regulation of fibrinolysis GO:0051918 9.43 F2 SERPINE1
21 acute inflammatory response to antigenic stimulus GO:0002438 9.4 ICAM1 SERPINC1
22 acute-phase response GO:0006953 9.33 F2 F8 IL6
23 cellular response to lipopolysaccharide GO:0071222 9.26 CCL2 ICAM1 IL6 SERPINE1
24 hemostasis GO:0007599 8.92 F2 F5 F8 SERPINC1

Sources for Post-Thrombotic Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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