MCID: PST095
MIFTS: 50

Post-Thrombotic Syndrome

Categories: Blood diseases, Cardiovascular diseases, Rare diseases

Aliases & Classifications for Post-Thrombotic Syndrome

MalaCards integrated aliases for Post-Thrombotic Syndrome:

Name: Post-Thrombotic Syndrome 12 15 17
Postphlebitic Syndrome 12 54 44 70
Postthrombotic Syndrome 70 32
Postphlebetic Syndrome with Ulcer and Inflammation 12
Postphlebetic Syndrome with Inflammation 12
Postphlebetic Syndrome with Ulcer 12
Venous Stress Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2364
ICD9CM 34 459.1
MeSH 44 D011186
SNOMED-CT 67 155460004
ICD10 32 I87.0
UMLS 70 C0032807 C0277919

Summaries for Post-Thrombotic Syndrome

Disease Ontology : 12 A venous insufficiency that is characterized by aching pain, heaviness, swelling, cramps, itching, or tingling in the affected limb and is a chronic complication of deep venous thrombosis.

MalaCards based summary : Post-Thrombotic Syndrome, also known as postphlebitic syndrome, is related to chronic venous insufficiency and venous insufficiency. An important gene associated with Post-Thrombotic Syndrome is F5 (Coagulation Factor V), and among its related pathways/superpathways are Integrin Pathway and Response to elevated platelet cytosolic Ca2+. The drugs Glucosamine and Plasminogen have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and heart, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 73 Post-thrombotic syndrome (PTS), also called postphlebitic syndrome and venous stress disorder is a... more...

Related Diseases for Post-Thrombotic Syndrome

Diseases in the Post-Thrombotic Syndrome family:

Rare Thrombotic Disorder Due to an Acquired Platelet Anomaly Rare Thrombotic Disorder Due to a Constitutional Platelet Anomaly
Rare Thrombotic Disorder Due to a Platelet Anomaly Rare Thrombotic Disorder Due to an Acquired Coagulation Factors Defect
Rare Thrombotic Disorder Due to a Constitutional Coagulation Factors Defect Rare Thrombotic Disorder Due to a Coagulation Factors Defect

Diseases related to Post-Thrombotic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 399)
# Related Disease Score Top Affiliating Genes
1 chronic venous insufficiency 31.8 VCAM1 SERPINE1 ICAM1 F2
2 venous insufficiency 30.8 VCAM1 SERPINE1 ICAM1 F5 F2
3 varicose veins 30.3 SERPINC1 IL6 ICAM1 F5 F2
4 thrombophilia due to thrombin defect 30.1 SERPINE1 SERPINC1 F8 F5 F3 F2
5 pulmonary embolism 30.0 SERPINE1 SERPINC1 F8 F5 F3 F2
6 exanthem 30.0 IL6 F3 F2
7 thrombosis 29.8 SERPINE1 SERPINC1 PLG F8 F5 F3
8 thrombophilia 29.8 SERPINE1 SERPINC1 F8 F5 F3 F2
9 portal vein thrombosis 29.7 SERPINE1 SERPINC1 F5 F2
10 thoracic outlet syndrome 29.7 SERPINC1 PLG F2
11 intermittent claudication 29.6 SERPINE1 SERPINC1 IL6 F2
12 protein c deficiency 29.6 SERPINE1 SERPINC1 F5 F2
13 lipid metabolism disorder 29.5 SERPINE1 IL6 CCL2 ADIPOQ
14 protein s deficiency 29.5 SERPINC1 F5 F3 F2
15 homocysteinemia 29.1 VCAM1 SERPINE1 SERPINC1 F5 F2 CCL2
16 thrombophlebitis 28.7 SERPINE1 SERPINC1 PLG F8 F5 F3
17 peripheral vascular disease 28.3 VCAM1 SERPINE1 SERPINC1 IL6 F5 F3
18 thrombophilia due to activated protein c resistance 28.3 SERPINE1 SERPINC1 PLG F8 F5 F3
19 pulmonary hypertension 28.2 SERPINE1 SERPINC1 PLG IL6 F3 F2
20 vascular disease 27.1 VCAM1 SERPINE1 SERPINC1 PLG IL6 ICAM1
21 paracetamol poisoning 10.4 F5 F2
22 arteritic anterior ischemic optic neuropathy 10.4 F5 F2
23 aspirin resistance 10.4 F5 F2
24 amaurosis fugax 10.3 SERPINE1 F5
25 factor v and factor viii, combined deficiency of, 2 10.3 F8 F5
26 pyridoxine deficiency anemia 10.3 VCAM1 F2
27 acute cholangitis 10.3 IL6 F2
28 anaerobic pneumonia 10.3 SERPINE1 IL6
29 fuchs' heterochromic uveitis 10.3 IL6 CCL2
30 generalized atherosclerosis 10.2 SERPINE1 IL6
31 sudden sensorineural hearing loss 10.2 IL6 F5 F2
32 pyuria 10.2 IL6 F2
33 achenbach syndrome 10.2 F3 F2
34 stachybotrys chartarum 10.2 IL6 CCL2
35 herpes simplex virus keratitis 10.2 ICAM1 CCL2
36 macular degeneration, age-related, 9 10.2 VCAM1 ICAM1
37 renal pelvis squamous cell carcinoma 10.2 F3 F2
38 papillary adenofibroma 10.2 F3 F2
39 femoral neuropathy 10.2 F3 F2
40 emphysematous cholecystitis 10.2 F3 F2
41 hemopneumothorax 10.2 F3 F2
42 dowling-degos disease 1 10.2
43 lipodermatosclerosis 10.2
44 cryptogenic cirrhosis 10.2 SERPINE1 F5 F2
45 severe nonproliferative diabetic retinopathy 10.2 ICAM1 CCL2
46 actinic prurigo 10.2 VCAM1 ICAM1
47 ankylosing spondylitis 1 10.2 F3 F2
48 pulmonary embolism and infarction 10.2 F3 F2
49 epidural abscess 10.2 F3 F2
50 denture stomatitis 10.2 IL6 CCL2

Comorbidity relations with Post-Thrombotic Syndrome via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease
Hypertension, Essential Peripheral Vascular Disease
Venous Insufficiency

Graphical network of the top 20 diseases related to Post-Thrombotic Syndrome:



Diseases related to Post-Thrombotic Syndrome

Symptoms & Phenotypes for Post-Thrombotic Syndrome

MGI Mouse Phenotypes related to Post-Thrombotic Syndrome:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.19 ADIPOQ F2 F3 F5 ICAM1 IL6
2 homeostasis/metabolism MP:0005376 10.18 ADIPOQ F2 F3 F5 F8 ICAM1
3 growth/size/body region MP:0005378 10.16 ADIPOQ F2 F3 F5 ICAM1 IL6
4 immune system MP:0005387 10.15 ADIPOQ CCL2 F2 F3 F8 ICAM1
5 cellular MP:0005384 10.13 ADIPOQ F2 F3 ICAM1 IL6 PLG
6 hematopoietic system MP:0005397 10.13 ADIPOQ F3 F8 ICAM1 IL6 PLG
7 mortality/aging MP:0010768 9.93 ADIPOQ F2 F3 F5 F8 ICAM1
8 integument MP:0010771 9.92 ADIPOQ F2 F3 F5 ICAM1 IL6
9 liver/biliary system MP:0005370 9.73 ADIPOQ F5 IL6 PLG SERPINC1 SERPINE1
10 neoplasm MP:0002006 9.43 ADIPOQ F3 ICAM1 IL6 PLG SERPINE1
11 respiratory system MP:0005388 9.1 ADIPOQ F2 F3 IL6 PLG SERPINE1

Drugs & Therapeutics for Post-Thrombotic Syndrome

Drugs for Post-Thrombotic Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
2 Plasminogen Phase 4
3 Tissue Plasminogen Activator Phase 4
4 Anticoagulants Phase 4
5 Fibrinolytic Agents Phase 4
6 Antimetabolites Phase 4
7 Lipid Regulating Agents Phase 4
8 Hypoglycemic Agents Phase 4
9 Hypolipidemic Agents Phase 4
10 Glucuronyl glucosamine glycan sulfate Phase 4
11
Troxerutin Investigational Phase 3 7085-55-4 5486699
12 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
13 Anticholesteremic Agents Phase 3
14 Rosuvastatin Calcium Phase 3 147098-20-2
15 Hormones Phase 3
16 Calcium, Dietary Phase 3
17
Calcium Nutraceutical Phase 3 7440-70-2 271
18
Rivaroxaban Approved Phase 2 366789-02-8
19
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
20 Analgesics, Non-Narcotic Phase 2
21 Cyclooxygenase Inhibitors Phase 2
22 Analgesics Phase 2
23 Antirheumatic Agents Phase 2
24 Anti-Inflammatory Agents Phase 2
25 Anti-Inflammatory Agents, Non-Steroidal Phase 2
26 Antipyretics Phase 2
27 Platelet Aggregation Inhibitors Phase 2
28
Thrombin Approved, Investigational
29
Ephedrine Approved 299-42-3 9294
30
Oxymetazoline Approved, Investigational 1491-59-4 4636
31
Pseudoephedrine Approved 90-82-4 7028
32
Vitamin K1 Approved, Investigational 84-80-0 5284607
33
Heparin Approved, Investigational 9005-49-6 772 9812414
34
Dalteparin Approved 9005-49-6
35
Tinzaparin Approved 9041-08-1, 9005-49-6 25244225
36
Edoxaban Approved 480449-70-5
37
Apixaban Approved 503612-47-3 10182969
38
Enoxaparin Approved 9005-49-6 772
39 Kava Approved, Investigational, Nutraceutical 9000-38-8
40
Menadione Approved, Nutraceutical 58-27-5 4055
41 Menaquinone Investigational 1182-68-9
42
Dabigatran Investigational 211914-51-1
43 Adrenergic alpha-Agonists
44 Vasoconstrictor Agents
45 Respiratory System Agents
46 Sympathomimetics
47 Neurotransmitter Agents
48 Adrenergic Agents
49 Nasal Decongestants
50 Adrenergic Agonists

Interventional clinical trials:

(show top 50) (show all 52)
# Name Status NCT ID Phase Drugs
1 The Efficacy of Rivaroxaban With Diosmin in the Long-term Treatment of Acute Proximal Deep Vein Thrombosis Completed NCT03413618 Phase 4 Rivaroxaban;Diosmin
2 Gliding Aids for Medical Compression Stockings - Practicability in Elderly Patients With Chronic Venous Insufficiency Completed NCT01432795 Phase 4
3 ACCElerated ThrombolySiS for Post-Thrombotic Syndrome Using the EKOS System Completed NCT02159521 Phase 4
4 Pharmacomechanical Catheter-directed Thrombolysis (PCDT) Plus Anticoagulation Compared to Anticoagulation Alone for Acute Primary Iliofemoral Deep Venous Thrombosis: Recruiting NCT04411316 Phase 4 Anticoagulation
5 Tinzaparin Lead-In to Prevent the Post-Thrombotic Syndrome Phase IV Pilot Study Not yet recruiting NCT04794569 Phase 4 tinzaparin;Rivaroxaban
6 Prospective Evaluation of the Quality of Life of Patients With Post-thrombotic Syndrome Who Receive Compression Therapy and Sulodexide - SQUARES Study Terminated NCT02512601 Phase 4 Sulodexide
7 Evaluation of a Venous-Return Assist Device (Venowave) to Treat Post-Thrombotic Syndrome: A Randomized Controlled Trial Completed NCT00182208 Phase 3
8 The SOX Trial: Compression Stockings to Prevent the Post-Thrombotic Syndrome After Symptomatic Proximal Deep Venous Thrombosis Completed NCT00143598 Phase 3
9 Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis--The ATTRACT Trial Completed NCT00790335 Phase 3 Recombinant tissue plasminogen activator (rt-PA)
10 Full-Leg vs Below-Knee Elastic Stockings for Prevention of the Post-Thrombotic Syndrome Completed NCT00426075 Phase 3
11 Resolution Enhancement by a Supplemental Obstruction Lessening Venoactive Drug for Eight Weeks in Deep Vein Thrombosis: A Pilot Study to Evaluate if Hydroxyethylrutoside Reduces the Risk of Post-Thrombotic Syndrome in Patients With DVT. Recruiting NCT04670432 Phase 3 Hydroxyethylrutoside
12 Statins for Venous Event Reduction in Patients With Venous Thromboembolism Recruiting NCT04319627 Phase 3 Rosuvastatin Calcium;Placebo Oral Tablet
13 The MUFFIN-PTS Trial: Micronized Purified Flavonoid Fraction for the Treatment of Post-Thrombotic Syndrome Not yet recruiting NCT03833024 Phase 3 Micronized Purified Flavonoid Fraction;Placebo
14 Evaluation of the Efficacy of the Thermal Cure in the Prevention of the Post-Thrombotic Syndrome After a Deep Venous Thrombosis of Lower Limbs. Terminated NCT00348907 Phase 3 thermal cure;late thermal cure
15 Pediatric High-Risk Deep Venous Thrombosis Lytic Outcomes Trial Withdrawn NCT02767232 Phase 3 Recombinant tissue plasminogen activator (rt-PA);Standard Anticoagulation Therapy
16 The Use of Intermittent Pneumatic Compression Device for Symptomatic Relief in Patients With Post Thrombotic Syndrome Unknown status NCT01637428 Phase 2
17 Aspirin® Plus Rivaroxaban Versus Rivaroxaban Alone for the Prevention of Venous Stent Thrombosis in Patients With Post-thrombotic Syndrome a Multi-center, International, Randomized, Open Label, Controlled Trial Recruiting NCT04128956 Phase 2 Aspirin 100mg
18 Long Term Natural History of PTS and Other Adverse Outcomes After Venous Thromboembolism in the Optimev Study (SPOT) Unknown status NCT03054727
19 Flow Augmentation With Geko Device in Patients With Postthrombotic Syndrome a Prospective Randomised Cross-Over Trial Unknown status NCT03111758
20 A Patient Outcome Study After Pharmacomechanical Catheter-directed Thrombolysis and Standard Treatment for Venous Thrombosis Unknown status NCT02113475
21 Comparison of the Recanalization Rate and Incidence of Postthrombotic Syndrome in Patients With Lower-limb Deep Venous Thrombosis Treated With Rivaroxaban or Warfarin Unknown status NCT02704598 Rivaroxaban;Warfarin
22 Evaluation of the Efficacy of Elastic Compression in Preventing Post-thrombotic Syndrome. Randomised Non-inferiority Study for Ankle Pressure Targeted at 25 mm Hg Versus 35 mm Hg Completed NCT01578122
23 Iliofemoral Thrombosis and Postthrombotic Syndrome: Registration and Analysis Within the Frankfurt Thrombophilia Registry Completed NCT03148548
24 Optimal Intensity and Frequency of a Portable Electrical Muscle Stimulator (VeinoPlus) to Improve Symptoms of Postthrombotic Syndrome Completed NCT00858130
25 A Randomized Trial to Determine the Impact of Lymphedema Therapy on Quality of Life and Disease Severity in Patients With Post-Thrombotic Syndrome Completed NCT00633971
26 The Prevalence of Post-Thrombotic Syndrome in Deep-Vein Thrombosis (DVT) Patients Treated With Dabigatran- a Cross-Sectional Assessment of RE-COVER Study Patients Completed NCT03050138
27 New Biomarkers in Post Thrombotic Syndrome Completed NCT02376764
28 Individually Tailored Elastic Compression Therapy After Deep Venous Thrombosis in Relation to the Incidence of Post Thrombotic Syndrome, a Randomized Multicenter Trial Completed NCT01429714
29 Physical Activity in Children at Risk of Post-thrombotic Sequelae: A Pilot Randomized Controlled Trial Completed NCT03075761
30 The Effect of PTA & Stenting on Intravenous Pressure in Deep Venous Obstructive Disease Before, After and During Ambulation on a Treadmill - Pilot Study. Completed NCT01846780
31 Non-interventional, Multicenter, Multinational Venous Stent Study for the Treatment of the Post-thrombotic Syndrome With Common Iliac Vein Compression Completed NCT02942394
32 Association of Thrombophilia and Inflammation With Post-Thrombotic Syndrome Completed NCT00395265
33 The Etiologic Role of Inflammation, Thrombophilia and Fibrinolysis in the Post-thrombotic Syndrome: The Bio-SOX Sub Study Completed NCT01615705
34 The BERN Ultrasound-enhanced Thrombolysis for Ilio-Femoral Deep Vein Thrombosis versUs Standard Catheter Directed thromboLysis Trial (BERNUTIFUL-Trial) Completed NCT01482273
35 EXPERT Trial: Exercise to Prevent Post-thrombotic Syndrome Elicited by Recent Thrombosis Completed NCT00910364
36 Long Term Outcomes of Venous Thromboembolism -the LOVE Study- Recruiting NCT02268630
37 Long-term Outcome After Heparin and Edoxaban Versus Heparin Plus Vitamin K Antagonists for Acute Deep Vein Thrombosis and Pulmonary Embolism HOKUSAÏ POST VT Recruiting NCT03757481
38 Bern Venous Stent Registry Recruiting NCT02433054
39 The Relationship Between Deep Venous Thrombus Characteristics and Venous Dynamics With Subsequent Thrombus Resolution and Post-thrombotic Syndrome Recruiting NCT04597138
40 Post-thrombotic Syndrome After Deep Venous Thrombosis (DVT) in Patients Treated According to the NOPHO ALL2008 Protocol Recruiting NCT04825548
41 Non-elastic Compression Garment Therapy Versus Control for Deep Vein Thrombosis: A Bayesian Adaptive Randomized Trial Recruiting NCT03368313
42 Russian Registry of Treatment of Venous Thromboembolism Recruiting NCT03881345 Anticoagulants
43 Chronic Venous Thrombosis: Relief With Adjunctive Catheter-Directed Therapy - The C-TRACT Trial Recruiting NCT03250247
44 Long-term Outcome After Edoxaban Versus Vitamin K Antagonists for Acute VTE Recruiting NCT04007653
45 Novel PET/CT and Treatment Strategies to Reduce PTS Following DVT Recruiting NCT03195777
46 A Prospective Randomized, Open-label, Blind Evaluator, Evaluating the Efficacy of Proximal Venous Angioplasty-stenting vs Optimal Medical Treatment on Post-thrombotic Syndrome Reduction Active, not recruiting NCT04250025
47 Pilot Study of Post-thrombotic Syndrome & Predictors of Recurrence in Cancer Patients With Catheter-related Thrombosis Active, not recruiting NCT01999179 Heparin, Low-Molecular-Weight, or direct oral anticoagulants
48 Role of a Novel Exercise Program to Prevent Post-thrombotic Syndrome Active, not recruiting NCT02148029
49 Compression Hosiery to Avoid Post-Thrombotic Syndrome (CHAPS) Not yet recruiting NCT04103112
50 Efficacy and Safety of Vascular Boot Warming Program After Acute DVT±PE for Earlier Resolution of Venous Thromboembolism (VTE) and Prevention of Post Thrombotic Syndrome: A Pilot Study. Terminated NCT03465735 Standard of Care

Search NIH Clinical Center for Post-Thrombotic Syndrome

Cochrane evidence based reviews: postphlebitic syndrome

Genetic Tests for Post-Thrombotic Syndrome

Anatomical Context for Post-Thrombotic Syndrome

MalaCards organs/tissues related to Post-Thrombotic Syndrome:

40
Skin, Endothelial, Heart, Cervix

Publications for Post-Thrombotic Syndrome

Articles related to Post-Thrombotic Syndrome:

(show top 50) (show all 1450)
# Title Authors PMID Year
1
Combined genetic defect (homogeneity for factor V Leiden and heterogeneity for prothrombin G20210A allele), in a young patient, with recurrent deep vein thrombosis and serious postphlebitic syndrome--a case report. 54 61
10779003 2000
2
Occult antithrombin III deficiency: a potentially lethal complication of the postphlebitic limb. 54 61
2325220 1990
3
Pharmacomechanical catheter thrombolysis for pregnancy-related proximal deep venous thrombosis: prevention of post-thrombotic syndrome. 61
31257966 2021
4
Less frequent post-thrombotic syndrome after successful catheter-directed thrombolysis for acute iliofemoral deep vein thrombosis. 61
32219735 2021
5
Endovascular and medical therapy of May-Thurner syndrome: Case series and scoping literature review. 61
33752850 2021
6
Successful treatment of acquired arteriovenous fistula following iliac vein thrombosis. 61
33761810 2021
7
Post-thrombotic syndrome after deep vein thrombosis: The role of follow-up Doppler ultrasound. 61
32139077 2021
8
A review of upper extremity deep vein thrombosis. 61
33618595 2021
9
The efficacy of rotational pharmaco-mechanical thrombectomy in patients with acute iliofemoral deep vein thrombosis: Is the standard treatment of deep vein thrombosis changing? 61
33092483 2021
10
Post-thrombotic syndrome - a position paper from European Society of Vascular Medicine. 61
33720757 2021
11
Leukocyte gene expression in post-thrombotic syndrome. 61
33713866 2021
12
Mid-term patency of iliac venous stenting for post-thrombotic syndrome: systematic review and meta-analysis. 61
33739078 2021
13
Comparing Safety and Efficacy of Rivaroxaban with Warfarin for Patients after Successful Stent Placement for Chronic Iliofemoral Occlusion: A Retrospective Single Institution Study. 61
33388238 2021
14
Pediatric May-Thurner Syndrome-Systematic review and individual patient data meta-analysis. 61
33651481 2021
15
Long-term outcomes following use of a composite Wallstent-Z stent approach to iliofemoral venous stenting. 61
32827734 2021
16
DEep VEin Lesion OPtimisation (DEVELOP) trial: protocol for a randomised, assessor-blinded feasibility trial of iliac vein intervention for venous leg ulcers. 61
33541436 2021
17
Clinical outcomes of venous self-expanding stent placement for iliofemoral venous outflow obstruction. 61
33548554 2021
18
Diagnostic and Technical Challenges in the Care of a Complex Patient With Post-Thrombotic Syndrome. 61
33563142 2021
19
Predictors for the risk and severity of post-thrombotic syndrome in vascular Behçet's disease. 61
33618067 2021
20
Performance of two clinical scales to assess quality of life in patients with post-thrombotic syndrome. 61
33548557 2021
21
Quality of life outcomes for patients undergoing venous stenting for chronic deep venous disease. 61
33540137 2021
22
Clinical efficacy of one-stage thrombus removal via contralateral femoral and ipsilateral tibial venous access for pharmacomechanical thrombectomy in entire-limb acute deep vein thrombosis: a retrospective cohort study. 61
33540135 2021
23
Outcomes of Aspirex®S thrombectomy system combined with catheter-directed thrombolysis for treating bilateral lower extremity deep venous thrombosis. 61
33359384 2021
24
Referral patterns for catheter-directed thrombolysis for iliofemoral deep venous thrombosis. 61
33428542 2021
25
Predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis: a cross-sectional study. 61
33419441 2021
26
Association between deep vein thrombosis and stent patency in symptomatic iliac vein compression syndrome: Systematic review and meta-analysis. 61
32827731 2021
27
Endovascular mechanical thrombectomy versus thrombolysis in patients with iliofemoral deep vein thrombosis - a systematic review and meta-analysis. 61
32449481 2021
28
Thrombolytic strategies versus standard anticoagulation for acute deep vein thrombosis of the lower limb. 61
33464575 2021
29
Contemporary nationwide trends and in-hospital outcomes of adjunctive stenting in patients undergoing catheter-directed thrombolysis for proximal deep venous thrombosis. 61
32522616 2021
30
A pilot randomized trial of atorvastatin as adjunct therapy in patients with acute venous thromboembolism. 61
33196511 2021
31
Surgical management of post-thrombotic syndrome in chronic venous thoracic outlet syndrome. 61
33429091 2021
32
Surgical and non-surgical approaches in the management of lower limb post-thrombotic syndrome. 61
33455484 2021
33
The Burden of Post-Thrombotic Syndrome in a Long-Term Retrospective Cohort in Northern Portugal. 61
33159722 2021
34
Long-term outcome after nonsurgical management of Paget-Schroetter syndrome. 61
32446004 2021
35
Paget-Schroetter Syndrome in a Young Female. 61
33749370 2021
36
Relaxation-Enhanced Angiography without Contrast and Triggering (REACT) for pelvic MR venography in comparison to balanced gradient-echo and T2-weighted spin-echo techniques. 61
33607595 2021
37
Direct Oral Anticoagulants in Patients With Inherited Thrombophilia and Venous Thromboembolism: A Prospective Cohort Study. 61
33222589 2020
38
Prevalence and Clinical Characteristics of Post-Thrombotic Syndrome in High-Altitude-Induced Deep Vein Thrombosis: Experience of a Single Tertiary Care Center from Real-World Settings. 61
32707006 2020
39
A Narrative Review of Aspirin Resistance in VTE Prophylaxis for Orthopaedic Surgery. 61
33037568 2020
40
Why Venous Leg Ulcers Have Difficulty Healing: Overview on Pathophysiology, Clinical Consequences, and Treatment. 61
33374372 2020
41
Medicine and Phlebolymphology: Time to Change? 61
33353052 2020
42
Characterization of Venous Involvement in Vasculo-Behçet Disease. 61
33115969 2020
43
Single-Session Treatment of Upper Extremity Deep Venous Thrombosis and Central Venous Catheter Malfunction Using the ClotTriever System. 61
33489489 2020
44
Long-term anticoagulant treatment in patients with inferior vena cava agenesis and deep vein thrombosis. 61
32977127 2020
45
Percutaneous mechanical thrombectomy of lower extremity deep vein thrombosis in a pediatric patient. 61
33134638 2020
46
Risk of post-thrombotic syndrome after deep vein thrombosis treated with rivaroxaban versus vitamin-K antagonists: A systematic review and meta-analysis. 61
32977134 2020
47
Experience of a 40-day (6 week) LMWH treatment for isolated distal deep vein thrombosis. 61
32189191 2020
48
Ten-year trends in iliofemoral deep vein thrombosis treatment and referral pathways. 61
33249975 2020
49
The good, bad and the ugly of the Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis trial from the viewpoint of clinicians. 61
32414676 2020
50
Effect of thrombophilia on clinical outcomes of chronic post-thrombotic patients after iliofemoral stenting with nitinol venous stents. 61
33186751 2020

Variations for Post-Thrombotic Syndrome

Expression for Post-Thrombotic Syndrome

Search GEO for disease gene expression data for Post-Thrombotic Syndrome.

Pathways for Post-Thrombotic Syndrome

Pathways related to Post-Thrombotic Syndrome according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.24 VCAM1 SERPINE1 PLG ICAM1 F2 CCL2
2
Show member pathways
13.15 SERPINE1 SERPINC1 PLG F8 F5 F3
3
Show member pathways
13.04 VCAM1 TLR9 SERPINE1 IL6 ICAM1 CCL2
4
Show member pathways
12.71 SERPINC1 F8 F5 F3 F2
5
Show member pathways
12.67 TLR9 PLG IL6 ICAM1 CCL2
6
Show member pathways
12.6 VCAM1 SERPINE1 PLG ICAM1
7
Show member pathways
12.57 TLR9 SERPINE1 IL6 F3
8
Show member pathways
12.44 PLG IL6 F2 CCL2
9
Show member pathways
12.13 SERPINE1 PLG IL6 ICAM1 F2 CCL2
10 11.95 VCAM1 ICAM1 CCL2
11 11.92 SERPINE1 IL6 ADIPOQ
12 11.87 IL6 ICAM1 CCL2
13 11.86 VCAM1 SERPINE1 PLG ICAM1 F3
14 11.85 VCAM1 IL6 ICAM1 CCL2
15 11.83 VCAM1 IL6 ICAM1 CCL2
16 11.75 VCAM1 IL6 ADIPOQ
17 11.74 IL6 ICAM1 CCL2
18
Show member pathways
11.7 SERPINE1 SERPINC1 PLG F8 F5 F3
19 11.63 VCAM1 SERPINE1 IL6 ICAM1 F3 CCL2
20
Show member pathways
11.55 VCAM1 IL6 ICAM1
21 11.55 VCAM1 TLR9 IL6 ICAM1
22 11.41 IL6 ICAM1 CCL2
23 11.39 PLG IL6 ICAM1
24 11.35 VCAM1 TLR9 IL6 ICAM1 CCL2
25 11.33 SERPINE1 SERPINC1 PLG F8 F5 F3
26 11.27 VCAM1 TLR9 IL6 ICAM1
27 11.08 ICAM1 F2 CCL2
28 10.99 IL6 ADIPOQ
29 10.96 PLG F2
30 10.84 VCAM1 ICAM1 CCL2
31 10.73 SERPINE1 PLG

GO Terms for Post-Thrombotic Syndrome

Cellular components related to Post-Thrombotic Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.1 VCAM1 TLR9 SERPINE1 SERPINC1 PLG ICAM1
2 extracellular region GO:0005576 9.9 TLR9 SERPINE1 SERPINC1 PLG IL6 F8
3 cell surface GO:0009986 9.77 VCAM1 PLG ICAM1 F3 ADIPOQ
4 endoplasmic reticulum lumen GO:0005788 9.72 SERPINC1 IL6 F8 F5 F2
5 blood microparticle GO:0072562 9.61 SERPINC1 PLG F2
6 platelet alpha granule lumen GO:0031093 9.56 SERPINE1 PLG F8 F5
7 collagen-containing extracellular matrix GO:0062023 9.5 SERPINE1 SERPINC1 PLG ICAM1 F3 F2
8 extracellular space GO:0005615 9.4 VCAM1 SERPINE1 SERPINC1 PLG IL6 ICAM1

Biological processes related to Post-Thrombotic Syndrome according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 regulation of cell shape GO:0008360 9.8 ICAM1 F2 CCL2
2 cytokine-mediated signaling pathway GO:0019221 9.8 VCAM1 IL6 ICAM1 F3 CCL2
3 cellular response to tumor necrosis factor GO:0071356 9.79 VCAM1 ICAM1 CCL2
4 cellular response to lipopolysaccharide GO:0071222 9.78 SERPINE1 IL6 ICAM1 CCL2
5 response to ethanol GO:0045471 9.77 VCAM1 ICAM1 ADIPOQ
6 platelet activation GO:0030168 9.74 IL6 F8 F2
7 platelet degranulation GO:0002576 9.73 SERPINE1 PLG F8 F5
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.72 IL6 ICAM1 ADIPOQ
9 cellular protein metabolic process GO:0044267 9.72 SERPINC1 PLG IL6 F5 F2
10 defense response to Gram-negative bacterium GO:0050829 9.71 TLR9 SERPINE1 IL6
11 response to nutrient GO:0007584 9.7 VCAM1 SERPINC1 ADIPOQ
12 acute-phase response GO:0006953 9.63 IL6 F8 F2
13 blood coagulation GO:0007596 9.63 SERPINC1 PLG F8 F5 F3 F2
14 positive regulation of immunoglobulin production GO:0002639 9.62 TLR9 IL6
15 blood coagulation, intrinsic pathway GO:0007597 9.61 F8 F2
16 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.6 TLR9 CCL2
17 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.58 IL6 ICAM1
18 positive regulation of blood coagulation GO:0030194 9.58 SERPINE1 F2
19 regulation of blood coagulation GO:0030193 9.56 SERPINC1 F2
20 fibrinolysis GO:0042730 9.54 SERPINE1 PLG F2
21 acute inflammatory response to antigenic stimulus GO:0002438 9.51 SERPINC1 ICAM1
22 membrane to membrane docking GO:0022614 9.49 VCAM1 ICAM1
23 negative regulation of fibrinolysis GO:0051918 9.43 SERPINE1 PLG F2
24 positive regulation of interleukin-8 production GO:0032757 9.35 TLR9 SERPINE1 IL6 F3 ADIPOQ
25 hemostasis GO:0007599 9.1 SERPINC1 PLG F8 F5 F3 F2

Molecular functions related to Post-Thrombotic Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.13 SERPINE1 SERPINC1 F3
2 signaling receptor binding GO:0005102 9.02 SERPINE1 PLG F2 CCL2 ADIPOQ

Sources for Post-Thrombotic Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....