MCID: PST047
MIFTS: 20

Post-Traumatic Epilepsy

Categories: Rare diseases

Aliases & Classifications for Post-Traumatic Epilepsy

MalaCards integrated aliases for Post-Traumatic Epilepsy:

Name: Post-Traumatic Epilepsy 53

Classifications:



Summaries for Post-Traumatic Epilepsy

MalaCards based summary : Post-Traumatic Epilepsy is related to epilepsy and brain injury. An important gene associated with Post-Traumatic Epilepsy is MTHFR (Methylenetetrahydrofolate Reductase). The drugs Phenytoin and Piracetam have been mentioned in the context of this disorder. Affiliated tissues include brain and temporal lobe.

Wikipedia : 76 Post-traumatic epilepsy (PTE) is a form of epilepsy that results from brain damage caused by physical... more...

Related Diseases for Post-Traumatic Epilepsy

Diseases related to Post-Traumatic Epilepsy via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 epilepsy 10.8
2 brain injury 10.2
3 traumatic brain injury 10.1
4 head injury 10.1
5 esophagitis 9.8

Graphical network of the top 20 diseases related to Post-Traumatic Epilepsy:



Diseases related to Post-Traumatic Epilepsy

Symptoms & Phenotypes for Post-Traumatic Epilepsy

Drugs & Therapeutics for Post-Traumatic Epilepsy

Drugs for Post-Traumatic Epilepsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenytoin Approved, Vet_approved Phase 3,Phase 2 57-41-0 1775
2 Piracetam Approved, Investigational Phase 3,Phase 2 7491-74-9
3
Valproic Acid Approved, Investigational Phase 3 99-66-1 3121
4
Biperiden Approved, Investigational Phase 3 514-65-8 2381
5 Etiracetam Investigational Phase 3,Phase 2 33996-58-6
6 Central Nervous System Depressants Phase 3,Phase 2
7 GABA Agents Phase 3
8 Sodium Channel Blockers Phase 3
9 Neuroprotective Agents Phase 3,Phase 2
10 Neurotransmitter Agents Phase 3
11 Nootropic Agents Phase 3,Phase 2
12 Tranquilizing Agents Phase 3
13 Diuretics, Potassium Sparing Phase 3
14 Pharmaceutical Solutions Phase 3,Phase 2
15 Anticonvulsants Phase 3,Phase 2
16 Protective Agents Phase 3,Phase 2
17 Psychotropic Drugs Phase 3
18 Antimanic Agents Phase 3
19 Cholinergic Agents Phase 3
20 Muscarinic Antagonists Phase 3
21 Cholinergic Antagonists Phase 3
22 Parasympatholytics Phase 3
23 Peripheral Nervous System Agents Phase 3
24 Antiparkinson Agents Phase 3
25 Autonomic Agents Phase 3
26 Biperiden lactate Phase 3
27 Ether Phase 2
28 Pregnanolone Phase 2 128-20-1
29 Anesthetics Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Double Blind Trial of Valproate Sodium for Prophylaxis of Post Traumatic Seizures Completed NCT00004817 Phase 3 phenytoin;valproate sodium
2 Use of Biperiden for the Prevention of Post-traumatic Epilepsy Recruiting NCT01048138 Phase 3 Biperiden Lactate;Placebo
3 Prevention of Post-traumatic Seizures With Levetiracetam Terminated NCT00566046 Phase 3 Levetiracetam;Placebo
4 Levetiracetam to Prevent Post-Traumatic Epilepsy Completed NCT01463033 Phase 2 Levetiracetam
5 Allopregnanolone for the Treatment of Traumatic Brain Injury Completed NCT01673828 Phase 2 Allopregnanolone injection;Placebo injection
6 Characteristics of Blood- Brain Barrier Permeability in Neurological Patients Unknown status NCT00419874
7 Observational Study of Cortical Spreading Depression in Human Brain Trauma Completed NCT00803036
8 Neuroimaging Biomarker for Seizures Recruiting NCT03441867 Not Applicable
9 Microvascular Injury and Blood-brain Barrier Dysfunction as Novel Biomarkers and Targets for Treatment in Traumatic Brain Injury Recruiting NCT03139682

Search NIH Clinical Center for Post-Traumatic Epilepsy

Genetic Tests for Post-Traumatic Epilepsy

Anatomical Context for Post-Traumatic Epilepsy

MalaCards organs/tissues related to Post-Traumatic Epilepsy:

41
Brain, Temporal Lobe

Publications for Post-Traumatic Epilepsy

Articles related to Post-Traumatic Epilepsy:

(show top 50) (show all 106)
# Title Authors Year
1
Epileptiform activity in traumatic brain injury predicts post-traumatic epilepsy. ( 29537656 )
2018
2
Algorithm for automatic detection of spontaneous seizures in rats with post-traumatic epilepsy. ( 29936072 )
2018
3
Rapamycin provides anti-epileptogenic effect in a rat model of post-traumatic epilepsy via deactivation of mTOR signaling pathway. ( 29904395 )
2018
4
In search of antiepileptogenic treatments for post-traumatic epilepsy. ( 29936231 )
2018
5
Big data sharing and analysis to advance research in post-traumatic epilepsy. ( 29864492 )
2018
6
Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study. ( 29859872 )
2018
7
Epileptic spasms in paediatric post-traumatic epilepsy at a tertiary referral centre. ( 28316319 )
2017
8
Post-traumatic epilepsy associations with mental health outcomes in the first two years after moderate to severe TBI: A TBI Model Systems analysis. ( 28658654 )
2017
9
Risk of post-traumatic epilepsy after severe head injury in patients with at least one seizure. ( 28919762 )
2017
10
Management of post-traumatic epilepsy: An evidence review over the last 5 years and future directions. ( 29588942 )
2017
11
Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy. ( 28753497 )
2017
12
Animal models of post-traumatic epilepsy. ( 27044802 )
2016
13
Progress on Post Traumatic Epilepsy and Its Forensic Evaluation. ( 29171740 )
2016
14
Late Post-traumatic Epilepsy in Children and Young Adults: Impropriety of Long-Term Antiepileptic Prophylaxis and Risks in Tapering. ( 26913859 )
2016
15
Modeling Post-Traumatic Epilepsy for Therapy Development ( 26583185 )
2016
16
Autoregressive spectral analysis of cortical electroencephalographic signals in a rat model of post-traumatic epilepsy. ( 26215653 )
2015
17
Post-traumatic epilepsy: clinical clues to pathogenesis and paths to prevention. ( 25701905 )
2015
18
Post-traumatic epilepsy in children-experience from a tertiary referral center. ( 25693582 )
2015
19
Epileptogenic focus localization in treatment-resistant post-traumatic epilepsy. ( 25542591 )
2015
20
Progressive, Seizure-Like, Spike-Wave Discharges Are Common in Both Injured and Uninjured Sprague-Dawley Rats: Implications for the Fluid Percussion Injury Model of Post-Traumatic Epilepsy. ( 26085641 )
2015
21
A rapid lateral fluid percussion injury rodent model of traumatic brain injury and post-traumatic epilepsy. ( 24553065 )
2014
22
Prophylaxis for post-traumatic epilepsy: can your kinase do that? ( 24526877 )
2014
23
Traumatic Brain Injury Causes a Tacrolimus-Sensitive Increase in Non-Convulsive Seizures in a Rat Model of Post-Traumatic Epilepsy. ( 25580467 )
2014
24
Subtypes of post-traumatic epilepsy: clinical, electrophysiological, and imaging features. ( 24693960 )
2014
25
Post-traumatic epilepsy: review of risks, pathophysiology, and potential biomarkers. ( 24763802 )
2014
26
Post-traumatic epilepsy with isolated memory flashbacks. ( 23531494 )
2013
27
Neural circuit mechanisms of post-traumatic epilepsy. ( 23785313 )
2013
28
Symptomatic diffuse esophageal spasm as a major ictal manifestation of post-traumatic epilepsy: a case report. ( 23121455 )
2013
29
PI3K-Akt signaling activates mTOR-mediated epileptogenesis in organotypic hippocampal culture model of post-traumatic epilepsy. ( 23699517 )
2013
30
Cutting through the complexity: the role of brain-derived neurotrophic factor in post-traumatic epilepsy (Commentary on Gill et al.). ( 24289826 )
2013
31
Treatment of post-traumatic epilepsy. ( 22723198 )
2012
32
Development of post-traumatic epilepsy after controlled cortical impact and lateral fluid-percussion-induced brain injury in the mouse. ( 22023672 )
2012
33
Results of phase II pharmacokinetic study of levetiracetam for prevention of post-traumatic epilepsy. ( 22771222 )
2012
34
A multimodal imaging approach to the evaluation of post-traumatic epilepsy. ( 22592963 )
2012
35
MTHFR C677T genotype as a risk factor for epilepsy including post-traumatic epilepsy in a representative military cohort. ( 21787169 )
2011
36
Progress on the issue of excitotoxic injury modification vs. real neuroprotection; implications for post-traumatic epilepsy. ( 21839755 )
2011
37
Progressive loss of phasic, but not tonic, GABAA receptor-mediated inhibition in dentate granule cells in a model of post-traumatic epilepsy in rats. ( 21840377 )
2011
38
Anti-epileptogenesis in rodent post-traumatic epilepsy models. ( 21402123 )
2011
39
Quality of life and its influencing factors in patients with post-traumatic epilepsy. ( 21453576 )
2011
40
Profile of post-traumatic epilepsy in Benin City, Nigeria. ( 20665457 )
2010
41
Post-traumatic epilepsy: an overview. ( 24761136 )
2010
42
Effect of vagus nerve stimulation in post-traumatic epilepsy and failed epilepsy surgery : preliminary report. ( 19096676 )
2008
43
Early post-traumatic epilepsy in a patient with initial normal CT scan. ( 18825806 )
2008
44
Blood-brain barrier disruption in post-traumatic epilepsy. ( 17991703 )
2008
45
Characteristics and surgical outcomes for medial temporal post-traumatic epilepsy. ( 18348018 )
2008
46
The impact of prophylactic treatment on post-traumatic epilepsy after severe traumatic brain injury. ( 17522989 )
2007
47
Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsy. ( 17070687 )
2007
48
Post traumatic epilepsy: a review of scientific evidence. ( 16850898 )
2006
49
Prevention and treatment of post-traumatic epilepsy. ( 16893349 )
2006
50
Animal models of post-traumatic epilepsy. ( 16503807 )
2006

Variations for Post-Traumatic Epilepsy

Expression for Post-Traumatic Epilepsy

Search GEO for disease gene expression data for Post-Traumatic Epilepsy.

Pathways for Post-Traumatic Epilepsy

GO Terms for Post-Traumatic Epilepsy

Sources for Post-Traumatic Epilepsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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