MCID: PST047
MIFTS: 20

Post-Traumatic Epilepsy

Categories: Rare diseases

Aliases & Classifications for Post-Traumatic Epilepsy

MalaCards integrated aliases for Post-Traumatic Epilepsy:

Name: Post-Traumatic Epilepsy 20

Classifications:



Summaries for Post-Traumatic Epilepsy

MalaCards based summary : Post-Traumatic Epilepsy is related to alzheimer disease and epilepsy. An important gene associated with Post-Traumatic Epilepsy is MTHFR (Methylenetetrahydrofolate Reductase). The drugs Phenytoin and Levetiracetam have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and eye, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 73 Post-traumatic epilepsy (PTE) is a form of acquired epilepsy that results from brain damage caused by... more...

Related Diseases for Post-Traumatic Epilepsy

Diseases related to Post-Traumatic Epilepsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 alzheimer disease 29.1 NRG1 MTHFR
2 epilepsy 10.9
3 traumatic brain injury 10.7
4 head injury 10.6
5 seizure disorder 10.5
6 brain injury 10.4
7 temporal lobe epilepsy 10.1
8 ocular motor apraxia 9.9
9 anxiety 9.9
10 migraine with aura 9.9
11 amnestic disorder 9.9
12 generalized anxiety disorder 9.9
13 disease of mental health 9.9
14 status epilepticus 9.9
15 encephalomalacia 9.9
16 post-traumatic stress disorder 9.9
17 focal epilepsy 9.9
18 movement disease 9.9
19 acute stress disorder 9.9
20 47,xyy 9.9
21 glioma 9.9
22 cerebral atrophy 9.9
23 dysphagia 9.9
24 myoclonus 9.9
25 glial tumor 9.9
26 psychotic disorder 9.7 NRG1 MTHFR
27 bipolar disorder 9.7 NRG1 MTHFR
28 autism 9.7 NRG1 MTHFR
29 autism spectrum disorder 9.6 NRG1 MTHFR
30 schizophrenia 9.6 NRG1 MTHFR

Graphical network of the top 20 diseases related to Post-Traumatic Epilepsy:



Diseases related to Post-Traumatic Epilepsy

Symptoms & Phenotypes for Post-Traumatic Epilepsy

GenomeRNAi Phenotypes related to Post-Traumatic Epilepsy according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-130 9.4 MTHFR NRG1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.4 MTHFR
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.4 MTHFR
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.4 NRG1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.4 MTHFR
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.4 MTHFR
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.4 MTHFR
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.4 MTHFR
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.4 MTHFR
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.4 MTHFR
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.4 MTHFR

Drugs & Therapeutics for Post-Traumatic Epilepsy

Drugs for Post-Traumatic Epilepsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenytoin Approved, Vet_approved Phase 2 57-41-0 1775
2
Levetiracetam Approved Phase 2 102767-28-2 441341
3 Anticonvulsants Phase 2
4 Nootropic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pilot: Levetiracetam to Prevent Post-Traumatic Epilepsy Completed NCT01463033 Phase 2 Levetiracetam
2 Imaging of Glial Activation and Risk for Post-Traumatic Epilepsy Recruiting NCT03999164 Phase 1 [18F]DPA-714 Positron Emission Tomography Scan

Search NIH Clinical Center for Post-Traumatic Epilepsy

Genetic Tests for Post-Traumatic Epilepsy

Anatomical Context for Post-Traumatic Epilepsy

MalaCards organs/tissues related to Post-Traumatic Epilepsy:

40
Brain, Temporal Lobe, Eye, Spinal Cord, Thalamus

Publications for Post-Traumatic Epilepsy

Articles related to Post-Traumatic Epilepsy:

(show top 50) (show all 429)
# Title Authors PMID Year
1
Apoptosis-antagonizing transcription factor is involved in rat post-traumatic epilepsy pathogenesis. 61
33717233 2021
2
Response of Voltage-Gated Sodium and Calcium Channels Subtypes on Dehydroepiandrosterone Treatment in Iron-Induced Epilepsy. 61
32318899 2021
3
Astrocytes and Epilepsy. 61
33661442 2021
4
Two decades of research towards a potential first anti-epileptic drug. 61
33714677 2021
5
Determinants of caregiver burden in male patients with epilepsy following penetrating traumatic brain injury. 61
33567399 2021
6
Post-traumatic epilepsy in adults: a nationwide register-based study. 61
33687971 2021
7
Post-traumatic seizures and antiepileptic therapy as predictors of the functional outcome in patients with traumatic brain injury. 61
33633297 2021
8
Manchester Arena Attack: management of paediatric penetrating brain injuries. 61
32677863 2021
9
Neuropathophysiological Mechanisms and Treatment Strategies for Post-traumatic Epilepsy. 61
33708071 2021
10
Repeated traumatic brain injury and risk of epilepsy: a Danish nationwide cohort study. 61
33439977 2021
11
An unusual case of coma related to glutamate receptor 3 (GluR3) auto-antibodies after a traumatic spinal cord injury: Clinical and pathological aspects. 61
33331219 2020
12
Early Increase in Cortical T2 Relaxation Is a Prognostic Biomarker for the Evolution of Severe Cortical Damage, but Not for Epileptogenesis, after Experimental Traumatic Brain Injury. 61
32349620 2020
13
Early brain biomarkers of post-traumatic seizures: initial report of the multicentre epilepsy bioinformatics study for antiepileptogenic therapy (EpiBioS4Rx) prospective study. 61
32848013 2020
14
Preventing epilepsy after traumatic brain injury: A propensity score analysis. 61
32858550 2020
15
Can we predict response to vagus nerve stimulation in intractable epilepsy. 61
31914344 2020
16
A review of seizures and epilepsy following traumatic brain injury. 61
32444981 2020
17
Antagonism of Macrophage Migration Inhibitory Factory (MIF) after Traumatic Brain Injury Ameliorates Astrocytosis and Peripheral Lymphocyte Activation and Expansion. 61
33050322 2020
18
Role of Innate Immune Receptor TLR4 and its endogenous ligands in epileptogenesis. 61
32871246 2020
19
In vivo KPT-350 treatment decreases cortical hyperexcitability following traumatic brain injury. 61
32853051 2020
20
Ameliorative effect of curcumin on altered expression of CACNA1A and GABRD in the pathogenesis of FeCl3-induced epilepsy. 61
32803504 2020
21
Tumor Necrosis Factor-α, the Pathological Key to Post-Traumatic Epilepsy: A Comprehensive Systematic Review. 61
32479057 2020
22
Pyrazolo[4,3-c]pyridine-4-one (PP-4-one) Exhibits Anti-Epileptogenic Effect in Rat Model of Traumatic Epilepsy by Mammalian Target of Rapamycin (mTOR) Signaling Pathway Downregulation. 61
32687486 2020
23
Progress in Research on Biomarkers of Post-Traumatic Epilepsy. 61
32705851 2020
24
Neuroinflammatory mechanisms of post-traumatic epilepsy. 61
32552898 2020
25
Complement in the Development of Post-Traumatic Epilepsy: Prospects for Drug Repurposing. 61
32000582 2020
26
Statistical Guidelines for Handling Missing Data in Traumatic Brain Injury Clinical Research. 61
32008424 2020
27
Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury. 61
32090988 2020
28
The Positive Allosteric Modulator of α2/3-Containing GABAA Receptors, KRM-II-81, Is Active in Pharmaco-Resistant Models of Epilepsy and Reduces Hyperexcitability after Traumatic Brain Injury. 61
31694876 2020
29
Identification of MicroRNA-Potassium Channel Messenger RNA Interactions in the Brain of Rats With Post-traumatic Epilepsy. 61
33597846 2020
30
Modeling of post-traumatic epilepsy and experimental research aimed at its prevention. 61
33331416 2020
31
Surgical Outcomes in Post-Traumatic Epilepsy: A Single Institutional Experience. 61
30924499 2020
32
Post-Traumatic Epilepsy and Seizure Susceptibility in Rat Models of Penetrating and Closed-Head Brain Injury. 61
31530242 2020
33
Iron Metabolism and Ferroptosis in Epilepsy. 61
33424539 2020
34
Neuronal injury and death following focal mild brain injury: The role of network excitability and seizure. 61
32405349 2020
35
Multiplex Networks to Characterize Seizure Development in Traumatic Brain Injury Patients. 61
33328863 2020
36
α-Helical protein absorption at post-traumatic epileptic foci monitored by Fourier transform infrared mapping. 61
32345781 2020
37
Animal Models of Post-Traumatic Epilepsy. 61
31861595 2019
38
Neuroinflammation in Post-Traumatic Epilepsy: Pathophysiology and Tractable Therapeutic Targets. 61
31717556 2019
39
Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis. 61
31076256 2019
40
Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis. 61
30981541 2019
41
Preface - Practical and theoretical considerations for performing a multi-center preclinical biomarker discovery study of post-traumatic epileptogenesis: lessons learned from the EpiBioS4Rx consortium. 61
30685321 2019
42
Potential therapeutic implications of ergogenic compounds on pathophysiology induced by traumatic brain injury: A narrative review. 61
31351083 2019
43
Progesterone modulates post-traumatic epileptogenesis through regulation of BDNF-TrkB signaling and cell survival-related pathways in the rat hippocampus. 61
31325580 2019
44
Post traumatic epilepsy: there is still much to learn. 61
31314837 2019
45
Clinical analysis on risk factors and prognosis of early post-traumatic epilepsy. 61
31314838 2019
46
The Level of Neuregulin-1 after Traumatic Brain Injury and Formation of Post-Traumatic Epilepsy. 61
31236887 2019
47
Retrospective Analysis of Forensic Appraisal of Post-traumatic Epilepsy in 30 Cases. 61
31282625 2019
48
Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury. 61
31282886 2019
49
Delayed creatine supplementation counteracts reduction of GABAergic function and protects against seizures susceptibility after traumatic brain injury in rats. 61
30742861 2019
50
Epilepsy-on-a-Chip System for Antiepileptic Drug Discovery. 61
30235116 2019

Variations for Post-Traumatic Epilepsy

Expression for Post-Traumatic Epilepsy

Search GEO for disease gene expression data for Post-Traumatic Epilepsy.

Pathways for Post-Traumatic Epilepsy

GO Terms for Post-Traumatic Epilepsy

Cellular components related to Post-Traumatic Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 synapse GO:0045202 8.62 NRG1 MTHFR

Sources for Post-Traumatic Epilepsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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