MCID: PST047
MIFTS: 19

Post-Traumatic Epilepsy

Categories: Rare diseases

Aliases & Classifications for Post-Traumatic Epilepsy

MalaCards integrated aliases for Post-Traumatic Epilepsy:

Name: Post-Traumatic Epilepsy 54

Classifications:



Summaries for Post-Traumatic Epilepsy

MalaCards based summary : Post-Traumatic Epilepsy is related to epilepsy and brain injury. An important gene associated with Post-Traumatic Epilepsy is MTHFR (Methylenetetrahydrofolate Reductase). The drugs Phenytoin and Valproic Acid have been mentioned in the context of this disorder. Affiliated tissues include brain and temporal lobe.

Wikipedia : 77 Post-traumatic epilepsy (PTE) is a form of epilepsy that results from brain damage caused by physical... more...

Related Diseases for Post-Traumatic Epilepsy

Diseases related to Post-Traumatic Epilepsy via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 epilepsy 10.9
2 brain injury 10.4
3 traumatic brain injury 10.3
4 head injury 10.2
5 seizure disorder 10.1
6 amnestic disorder 9.9
7 disease of mental health 9.9

Graphical network of the top 20 diseases related to Post-Traumatic Epilepsy:



Diseases related to Post-Traumatic Epilepsy

Symptoms & Phenotypes for Post-Traumatic Epilepsy

Drugs & Therapeutics for Post-Traumatic Epilepsy

Drugs for Post-Traumatic Epilepsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenytoin Approved, Vet_approved Phase 3,Phase 2 57-41-0 1775
2
Valproic Acid Approved, Investigational Phase 3 99-66-1 3121
3
Levetiracetam Approved, Investigational Phase 3,Phase 2 102767-28-2 441341
4
Biperiden Approved, Investigational Phase 3 514-65-8 2381
5 Psychotropic Drugs Phase 3
6 Diuretics, Potassium Sparing Phase 3
7 Neurotransmitter Agents Phase 3
8 GABA Agents Phase 3
9 Tranquilizing Agents Phase 3
10 Central Nervous System Depressants Phase 3,Phase 2
11 Sodium Channel Blockers Phase 3
12 Antimanic Agents Phase 3
13 Anticonvulsants Phase 3,Phase 2
14 Pharmaceutical Solutions Phase 3,Phase 2
15 Nootropic Agents Phase 3,Phase 2
16 Parasympatholytics Phase 3
17 Biperiden lactate Phase 3
18 Peripheral Nervous System Agents Phase 3
19 Cholinergic Antagonists Phase 3
20 Muscarinic Antagonists Phase 3
21 Autonomic Agents Phase 3
22 Cholinergic Agents Phase 3
23 Antiparkinson Agents Phase 3
24 Ether Phase 2
25 Pregnanolone Phase 2 128-20-1
26 Anesthetics Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Double Blind Trial of Valproate Sodium for Prophylaxis of Post Traumatic Seizures Completed NCT00004817 Phase 3 phenytoin;valproate sodium
2 Use of Biperiden for the Prevention of Post-traumatic Epilepsy Recruiting NCT01048138 Phase 3 Biperiden Lactate;Placebo
3 Prevention of Post-traumatic Seizures With Levetiracetam Terminated NCT00566046 Phase 3 Levetiracetam;Placebo
4 Levetiracetam to Prevent Post-Traumatic Epilepsy Completed NCT01463033 Phase 2 Levetiracetam
5 Allopregnanolone for the Treatment of Traumatic Brain Injury Completed NCT01673828 Phase 2 Allopregnanolone injection;Placebo injection
6 Characteristics of Blood- Brain Barrier Permeability in Neurological Patients Unknown status NCT00419874
7 Observational Study of Cortical Spreading Depression in Human Brain Trauma Completed NCT00803036
8 Neuroimaging Biomarker for Seizures Recruiting NCT03441867 Not Applicable
9 Microvascular Injury and Blood-brain Barrier Dysfunction as Novel Biomarkers and Targets for Treatment in Traumatic Brain Injury Recruiting NCT03139682

Search NIH Clinical Center for Post-Traumatic Epilepsy

Genetic Tests for Post-Traumatic Epilepsy

Anatomical Context for Post-Traumatic Epilepsy

MalaCards organs/tissues related to Post-Traumatic Epilepsy:

42
Brain, Temporal Lobe

Publications for Post-Traumatic Epilepsy

Articles related to Post-Traumatic Epilepsy:

(show top 50) (show all 116)
# Title Authors Year
1
Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy. ( 30059725 )
2019
2
Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis. ( 31076256 )
2019
3
Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis. ( 30981541 )
2019
4
Surgical Outcomes in Post-Traumatic Epilepsy: A Single Institutional Experience. ( 30924499 )
2019
5
Targeting neurodegeneration to prevent post-traumatic epilepsy. ( 30099094 )
2019
6
Breakdown of blood brain barrier as a mechanism of post-traumatic epilepsy. ( 30030025 )
2019
7
Big data sharing and analysis to advance research in post-traumatic epilepsy. ( 29864492 )
2019
8
Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study. ( 29859872 )
2019
9
Applying participatory action research in traumatic brain injury studies to prevent post-traumatic epilepsy. ( 30031158 )
2018
10
Epileptiform activity in traumatic brain injury predicts post-traumatic epilepsy. ( 29537656 )
2018
11
Seizure manifesting as a reaching/grasping movement in a patient with post-traumatic epilepsy. ( 30455935 )
2018
12
Dysregulated Glucose Metabolism as a Therapeutic Target to Reduce Post-traumatic Epilepsy. ( 30459556 )
2018
13
Algorithm for automatic detection of spontaneous seizures in rats with post-traumatic epilepsy. ( 29936072 )
2018
14
In search of antiepileptogenic treatments for post-traumatic epilepsy. ( 29936231 )
2018
15
Rapamycin provides anti-epileptogenic effect in a rat model of post-traumatic epilepsy via deactivation of mTOR signaling pathway. ( 29904395 )
2018
16
Management of post-traumatic epilepsy: An evidence review over the last 5 years and future directions. ( 29588942 )
2017
17
Risk of post-traumatic epilepsy after severe head injury in patients with at least one seizure. ( 28919762 )
2017
18
Epileptic spasms in paediatric post-traumatic epilepsy at a tertiary referral centre. ( 28316319 )
2017
19
Post-traumatic epilepsy associations with mental health outcomes in the first two years after moderate to severe TBI: A TBI Model Systems analysis. ( 28658654 )
2017
20
Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy. ( 28753497 )
2017
21
Late Post-traumatic Epilepsy in Children and Young Adults: Impropriety of Long-Term Antiepileptic Prophylaxis and Risks in Tapering. ( 26913859 )
2016
22
Animal models of post-traumatic epilepsy. ( 27044802 )
2016
23
Progress on Post Traumatic Epilepsy and Its Forensic Evaluation. ( 29171740 )
2016
24
Epileptogenic focus localization in treatment-resistant post-traumatic epilepsy. ( 25542591 )
2015
25
Post-traumatic epilepsy in children-experience from a tertiary referral center. ( 25693582 )
2015
26
Post-traumatic epilepsy: clinical clues to pathogenesis and paths to prevention. ( 25701905 )
2015
27
Progressive, Seizure-Like, Spike-Wave Discharges Are Common in Both Injured and Uninjured Sprague-Dawley Rats: Implications for the Fluid Percussion Injury Model of Post-Traumatic Epilepsy. ( 26085641 )
2015
28
Autoregressive spectral analysis of cortical electroencephalographic signals in a rat model of post-traumatic epilepsy. ( 26215653 )
2015
29
Prophylaxis for post-traumatic epilepsy: can your kinase do that? ( 24526877 )
2014
30
A rapid lateral fluid percussion injury rodent model of traumatic brain injury and post-traumatic epilepsy. ( 24553065 )
2014
31
Subtypes of post-traumatic epilepsy: clinical, electrophysiological, and imaging features. ( 24693960 )
2014
32
Post-traumatic epilepsy: review of risks, pathophysiology, and potential biomarkers. ( 24763802 )
2014
33
Post-traumatic epilepsy: current and emerging treatment options. ( 25143737 )
2014
34
Traumatic Brain Injury Causes a Tacrolimus-Sensitive Increase in Non-Convulsive Seizures in a Rat Model of Post-Traumatic Epilepsy. ( 25580467 )
2014
35
Post-traumatic epilepsy with isolated memory flashbacks. ( 23531494 )
2013
36
PI3K-Akt signaling activates mTOR-mediated epileptogenesis in organotypic hippocampal culture model of post-traumatic epilepsy. ( 23699517 )
2013
37
Neural circuit mechanisms of post-traumatic epilepsy. ( 23785313 )
2013
38
Cutting through the complexity: the role of brain-derived neurotrophic factor in post-traumatic epilepsy (Commentary on Gill et al.). ( 24289826 )
2013
39
Symptomatic diffuse esophageal spasm as a major ictal manifestation of post-traumatic epilepsy: a case report. ( 23121455 )
2013
40
Development of post-traumatic epilepsy after controlled cortical impact and lateral fluid-percussion-induced brain injury in the mouse. ( 22023672 )
2012
41
A multimodal imaging approach to the evaluation of post-traumatic epilepsy. ( 22592963 )
2012
42
Treatment of post-traumatic epilepsy. ( 22723198 )
2012
43
Results of phase II pharmacokinetic study of levetiracetam for prevention of post-traumatic epilepsy. ( 22771222 )
2012
44
Anti-epileptogenesis in rodent post-traumatic epilepsy models. ( 21402123 )
2011
45
Quality of life and its influencing factors in patients with post-traumatic epilepsy. ( 21453576 )
2011
46
MTHFR C677T genotype as a risk factor for epilepsy including post-traumatic epilepsy in a representative military cohort. ( 21787169 )
2011
47
Progress on the issue of excitotoxic injury modification vs. real neuroprotection; implications for post-traumatic epilepsy. ( 21839755 )
2011
48
Progressive loss of phasic, but not tonic, GABAA receptor-mediated inhibition in dentate granule cells in a model of post-traumatic epilepsy in rats. ( 21840377 )
2011
49
Profile of post-traumatic epilepsy in Benin City, Nigeria. ( 20665457 )
2010
50
Post-traumatic epilepsy: an overview. ( 24761136 )
2010

Variations for Post-Traumatic Epilepsy

Expression for Post-Traumatic Epilepsy

Search GEO for disease gene expression data for Post-Traumatic Epilepsy.

Pathways for Post-Traumatic Epilepsy

GO Terms for Post-Traumatic Epilepsy

Sources for Post-Traumatic Epilepsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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