PTSD
MCID: PST028
MIFTS: 58

Post-Traumatic Stress Disorder (PTSD)

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Post-Traumatic Stress Disorder

MalaCards integrated aliases for Post-Traumatic Stress Disorder:

Name: Post-Traumatic Stress Disorder 12 29 42 15 17 71 32
Stress Disorders, Post-Traumatic 43
Post Traumatic Stress Disorder 74
Posttraumatic Stress Disorder 15
Traumatic Neurosis 12
Ptsd 47

Classifications:



External Ids:

Disease Ontology 12 DOID:2055
ICD9CM 34 309.81
MeSH 43 D013313
NCIt 49 C3389
SNOMED-CT 67 47505003
ICD10 32 F43.1 F43.10
UMLS 71 C0038436

Summaries for Post-Traumatic Stress Disorder

MedlinePlus : 42 Post-traumatic stress disorder (PTSD) is a real illness. You can get PTSD after living through or seeing a traumatic event, such as war, a hurricane, sexual assault, physical abuse, or a bad accident. PTSD makes you feel stressed and afraid after the danger is over. It affects your life and the people around you. PTSD can cause problems like Flashbacks, or feeling like the event is happening again Trouble sleeping or nightmares Feeling alone Angry outbursts Feeling worried, guilty, or sad PTSD starts at different times for different people. Signs of PTSD may start soon after a frightening event and then continue. Other people develop new or more severe signs months or even years later. PTSD can happen to anyone, even children. Treatment may include talk therapy, medicines, or both. Treatment might take 6 to 12 weeks. For some people, it takes longer. NIH: National Institute of Mental Health

MalaCards based summary : Post-Traumatic Stress Disorder, also known as stress disorders, post-traumatic, is related to acute stress disorder and traumatic brain injury, and has symptoms including nervousness An important gene associated with Post-Traumatic Stress Disorder is LINC01090 (Long Intergenic Non-Protein Coding RNA 1090), and among its related pathways/superpathways are Circadian entrainment and cAMP signaling pathway. The drugs Tramadol and Diazepam have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related phenotypes are behavior/neurological and homeostasis/metabolism

Disease Ontology : 12 An anxiety disorder which results from a traumatic experience that results in psychological trauma.

Wikipedia : 74 Posttraumatic stress disorder (PTSD)[note 1] is a mental disorder that can develop after a person is... more...

Related Diseases for Post-Traumatic Stress Disorder

Diseases related to Post-Traumatic Stress Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 503)
# Related Disease Score Top Affiliating Genes
1 acute stress disorder 33.9 SLC6A4 NR3C1 FKBP5 CRP CRH BDNF
2 traumatic brain injury 33.7 DRD2 COMT BDNF APOE
3 brain injury 32.1 DRD2 COMT BDNF APOE
4 depression 32.0 SLC6A4 MAOA HTR2A CRH BDNF
5 anxiety 31.9 SLC6A4 NR3C1 MAOB MAOA HTR2A FKBP5
6 alcohol use disorder 31.7 SLC6A4 HTR2A DRD2 CRH COMT BDNF
7 adjustment disorder 31.5 SLC6A4 HTR2A BDNF
8 neurotic disorder 31.5 SLC6A4 MAOA HTR2A BDNF
9 chronic pain 31.5 COMT CNR1
10 alexithymia 31.5 SLC6A4 DRD2 CRP COMT
11 amnestic disorder 31.5 PREP DRD2 CNR1 BDNF APOE
12 sleep disorder 31.5 SLC6A4 HTR2A DRD2 CRP BDNF
13 somatization disorder 31.4 SLC6A4 HTR2A CRH
14 sexual disorder 31.4 SLC6A4 HTR2A DRD2
15 avoidant personality disorder 31.4 SLC6A4 MAOA DRD2
16 panic disorder 31.3 SLC6A4 MAOA HTR2A DRD2 CRH COMT
17 mental depression 31.3 SLC6A4 NR3C1 MAOA HTR2A FKBP5 DRD2
18 substance abuse 31.2 SLC6A4 MAOA HTR2A DRD2 DBH CRH
19 social phobia 31.2 SLC6A4 MAOA DRD2 COMT
20 sleep apnea 31.2 SLC6A4 IL1B HTR2A CRP BDNF APOE
21 postpartum depression 31.1 SLC6A4 MAOA CRH COMT BDNF
22 borderline personality disorder 31.1 SLC6A4 NR3C1 MAOA HTR2A FKBP5 DRD2
23 mood disorder 31.1 SLC6A4 NR3C1 MAOB MAOA HTR2A DRD2
24 conduct disorder 31.1 SLC6A4 MAOA DRD2 DBH COMT
25 agoraphobia 31.1 SLC6A4 MAOA HTR2A COMT
26 substance dependence 31.1 SLC6A4 MAOA DRD2 CRH COMT CNR1
27 personality disorder 31.1 SLC6A4 NR3C1 MAOB MAOA HTR2A FKBP5
28 dysthymic disorder 31.0 SLC6A4 MAOA HTR2A CRH BDNF
29 phobia, specific 31.0 SLC6A4 MAOA COMT
30 opiate dependence 31.0 SLC6A4 DRD2 CRH
31 dementia 31.0 MAOB MAOA HTR2A DRD2 COMT BDNF
32 dissociative disorder 31.0 SLC6A4 HTR2A FKBP5
33 psychotic disorder 30.9 SLC6A4 MAOB MAOA HTR2A DRD2 DBH
34 drug dependence 30.9 SLC6A4 DRD2 CRH CNR1 BDNF
35 irritable bowel syndrome 30.9 SLC6A4 HTR2A CRH COMT CNR1 BDNF
36 pure autonomic failure 30.9 MAOB MAOA DBH
37 heroin dependence 30.9 SLC6A4 MAOA DRD2 COMT BDNF
38 vascular dementia 30.9 IL1B CRP APOE
39 generalized anxiety disorder 30.8 SLC6A4 NR3C1 MAOA HTR2A DRD2 CRP
40 cannabis dependence 30.8 FAAH COMT CNR1
41 fibromyalgia 30.8 SLC6A4 PREP IL1B HTR2A DRD2 CRP
42 antisocial personality disorder 30.8 SLC6A4 MAOB MAOA HTR2A DRD2 COMT
43 bipolar i disorder 30.8 SLC6A4 HTR2A DRD2 COMT BDNF
44 eating disorder 30.7 SLC6A4 HTR2A FAAH DRD2 CRH COMT
45 hypochondriasis 30.7 SLC6A4 HTR2A BDNF
46 bulimia nervosa 30.7 SLC6A4 MAOA HTR2A DRD2 CRH COMT
47 chronic fatigue syndrome 30.7 SLC6A4 NR3C1 MAOA IL1B HTR2A CRH
48 cocaine dependence 30.7 SLC6A4 MAOB HTR2A DRD2 DBH COMT
49 alcohol dependence 30.7 SLC6A4 MAOB MAOA HTR2A FAAH DRD2
50 pulmonary disease, chronic obstructive 30.7 SLC6A4 NR3C1 IL1B CRP

Comorbidity relations with Post-Traumatic Stress Disorder via Phenotypic Disease Network (PDN):


Anxiety Dysthymic Disorder
Major Depressive Disorder

Graphical network of the top 20 diseases related to Post-Traumatic Stress Disorder:



Diseases related to Post-Traumatic Stress Disorder

Symptoms & Phenotypes for Post-Traumatic Stress Disorder

UMLS symptoms related to Post-Traumatic Stress Disorder:


nervousness

MGI Mouse Phenotypes related to Post-Traumatic Stress Disorder:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.44 ADCYAP1 ADCYAP1R1 APOE BDNF CNR1 COMT
2 homeostasis/metabolism MP:0005376 10.41 ADCYAP1 ADCYAP1R1 APOE BDNF CNR1 COMT
3 nervous system MP:0003631 10.27 ADCYAP1 ADCYAP1R1 APOE BDNF CNR1 COMT
4 growth/size/body region MP:0005378 10.26 ADCYAP1 ADCYAP1R1 APOE BDNF CNR1 CRH
5 mortality/aging MP:0010768 10.22 ADCYAP1 ADCYAP1R1 APOE BDNF CNR1 DBH
6 endocrine/exocrine gland MP:0005379 10.15 APOE BDNF COMT CRH DBH DRD2
7 adipose tissue MP:0005375 10.13 ADCYAP1 APOE CNR1 CRH DBH DRD2
8 integument MP:0010771 10.13 APOE BDNF CNR1 CRH DBH DRD2
9 normal MP:0002873 9.96 ADCYAP1R1 BDNF CNR1 CRH DBH DRD2
10 no phenotypic analysis MP:0003012 9.92 ADCYAP1 ADCYAP1R1 APOE BDNF CNR1 CRH
11 renal/urinary system MP:0005367 9.76 APOE COMT CRH DRD2 FKBP5 MAOB
12 reproductive system MP:0005389 9.61 ADCYAP1 ADCYAP1R1 APOE BDNF CNR1 COMT
13 taste/olfaction MP:0005394 8.92 APOE BDNF CNR1 DRD2

Drugs & Therapeutics for Post-Traumatic Stress Disorder

Drugs for Post-Traumatic Stress Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 367)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
2
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
3
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
4
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
5
Cycloserine Approved Phase 4 68-41-7 401 6234
6
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
7
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
8
Mifepristone Approved, Investigational Phase 4 84371-65-3 55245
9
Lamotrigine Approved, Investigational Phase 4 84057-84-1 3878
10
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
11
Mianserin Approved, Investigational Phase 4 24219-97-4 4184
12
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
13
Histamine Approved, Investigational Phase 4 51-45-6 774
14
Dronabinol Approved, Illicit Phase 4 1972-08-3 16078
15
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
16
Haloperidol Approved Phase 4 52-86-8 3559
17
Asenapine Approved Phase 4 85650-56-2, 65576-45-6 3001386
18
Memantine Approved, Investigational Phase 4 19982-08-2 4054
19
Levodopa Approved Phase 4 59-92-7 6047
20
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
21
Citalopram Approved Phase 4 59729-33-8 2771
22
Vortioxetine Approved, Investigational Phase 4 508233-74-7 9966051
23
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
24
Suvorexant Approved, Investigational Phase 4 1030377-33-3
25
Promethazine Approved, Investigational Phase 4 60-87-7 4927
26
Bupropion Approved Phase 4 34911-55-2, 34841-39-9 444
27
Carbon monoxide Approved, Investigational Phase 4 630-08-0 281
28
Fluvoxamine Approved, Investigational Phase 4 54739-18-3 3404 5324346
29
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
30
Pimavanserin Approved, Investigational Phase 4 706779-91-1 16058810
31
Prazosin Approved Phase 4 19216-56-9 4893
32
Sertraline Approved Phase 4 79617-96-2 68617
33
Propranolol Approved, Investigational Phase 4 525-66-6 4946
34
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
35
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
36
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
37
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
38
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
39 Olive Phase 4
40 Antineoplastic Agents, Hormonal Phase 4
41 Analgesics, Non-Narcotic Phase 4
42 Autonomic Agents Phase 4
43 Quetiapine Fumarate Phase 4 111974-72-2
44 Anti-Infective Agents Phase 4
45 Calcium, Dietary Phase 4
46 calcium channel blockers Phase 4
47 Renal Agents Phase 4
48 Antitubercular Agents Phase 4
49 Antibiotics, Antitubercular Phase 4
50 Anti-Bacterial Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 1632)
# Name Status NCT ID Phase Drugs
1 A Prospective Double Blind Randomized Placebo Controlled Trial of Repetitive Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder Unknown status NCT00134446 Phase 4
2 A Double-Blind, Placebo-Controlled, Flexible-Dose Pilot Clinical Trial of Once-Daily Extended-Release Tramadol for the Treatment of PTSD Unknown status NCT01517711 Phase 4 Tramadol;Placebo
3 The Effect of 21-Days Intranasal Oxytocin on Clinical Symptoms and Social Function in Patients With Post Traumatic Stress Disorder (PTSD), a Randomized Controled Trail Unknown status NCT02336568 Phase 4 Oxytoine;PLACEBO
4 Predictors of Treatment Response to Fluoxetine in PTSD Following a Recent History of War Zone Stress Exposure Unknown status NCT00633685 Phase 4 Fluoxetine;Placebo
5 A Randomized Cross Over Trial of Two Treatments for Obstructive Sleep Apnea in Veterans With Post Traumatic Stress Disorder Unknown status NCT01535586 Phase 4
6 Posttraumatic Stress Disorder and Affective Functioning: A Test of the Potentially Normalizing Effects of Oxytocin Unknown status NCT02546570 Phase 4 Oxytocin;Placebo
7 Early Pharmacological Intervention With Diazepam in the Emergency Room Setting to Prevent Posttraumatic Stress Disorder (PTSD). Unknown status NCT01221883 Phase 4 Diazepam
8 Identifying Neural Mechanisms of PTSD Symptom Reduction Induced by Combined Estrogen and Prolonged Exposure Therapy Unknown status NCT03371654 Phase 4 Estradiol;Placebo
9 Fear Conditioning, Extinction and Recall in Healthy Subjects and in Obsessive-compulsive Disorder Patients Pre and Post Treatment With Sertraline. Unknown status NCT03068429 Phase 4 Sertraline Hydrochloride
10 Double Blind, Placebo-Controlled Trial of THC as add-on Therapy for PTSD Unknown status NCT00965809 Phase 4 Tetrahydrocannabinol
11 Neurofunctional Markers of SSRI Treatment Response in PTSD Completed NCT00700999 Phase 4 Paroxetine
12 Eszopiclone for the Treatment of PTSD Completed NCT01605253 Phase 4 Eszopiclone;Placebo
13 Prophylaxis of Posttraumatic Stress Disorder With Post-Trauma Propranolol Completed NCT00158262 Phase 4 Propranolol;Placebo
14 Randomized Trial of Sertraline, Prolonged Exposure, and Their Combination for Post-traumatic Stress Disorder (PTSD) in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF). Completed NCT01524133 Phase 4 Sertraline
15 Naltrexone and Cognitive-Behavioral Therapy for Patients With Alcoholism and Post-Traumatic Stress Disorder Completed NCT00006489 Phase 4 Naltrexone;Placebo
16 Reducing Suicidal Ideation Through Treatment of Nightmares-PTSD Completed NCT02199652 Phase 4 Prazosin;Placebo
17 Geodon (Ziprasidone) for Posttraumatic Stress Disorder Completed NCT00208208 Phase 4 Ziprasidone
18 Combined Treatment With a Benzodiazepine (Clonazepam) and a Selective Serotonin Reuptake Inhibitor (Paroxetine) for Rapid Treatment of Posttraumatic Stress Disorder (PTSD) Completed NCT00025740 Phase 4 clonazepam and paroxetine
19 Risperidone Monotherapy in the Treatment of PTSD in Women Survivors of Domestic Abuse and Rape Trauma: a Double-Blind, Placebo Controlled, Randomized Clinical Trial Completed NCT00208182 Phase 4 Risperidone
20 Topiramate in the Treatment of Post Traumatic Stress Disorder (PTSD) Completed NCT00203463 Phase 4 topiramate
21 Effects of Escitalopram on Autonomic Reactivity in Post Traumatic Stress Disorder Among Veterans of Operation Enduring Freedom and Iraqi Freedom (OEF/OIF) Completed NCT01271244 Phase 4 Escitalopram
22 A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Determine the Efficacy and Safety of Topiramate in the Treatment of Posttraumatic Stress Disorder in Civilians Completed NCT00208130 Phase 4 Topiramate
23 Coordinated Anxiety Learning and Management (CALM): Improving Primary Care Anxiety Outcomes Completed NCT00347269 Phase 4 Psychotropic medication optimization
24 Eszopiclone for Sleep Disturbance and Nightmares in Post-Traumatic Stress Disorder Completed NCT00120250 Phase 4 Eszopiclone
25 Developing Memory Reconsolidation Blockers as Novel PTSD Treatments Completed NCT01490697 Phase 4 Mifepristone;d-Cycloserine;Placebo-matching Mifepristone;Placebo-matching d-Cycloserine (DCS)
26 The Outcome of Treatment of Traumatised Refugees With Trauma-Focused Cognitive Behavioural Therapy and / or Antidepressants - a Randomised Controlled Trial Completed NCT00917397 Phase 4 Sertraline
27 Cognitive Behavioral Therapy vs. Sertraline in the Treatment of Post Traumatic Stress Disorder Completed NCT00391430 Phase 4 Sertraline
28 Telemedicine Outreach for Post Traumatic Stress in CBOCs Completed NCT00821678 Phase 4
29 Atomoxetine in Comorbid ADHD/PTSD: A Pilot, Placebo-Controlled Feasibility Study Completed NCT02287038 Phase 4 Atomoxetine 80 MG
30 The Effect of Intranasal Oxytocin on Emphatic Abilities in Patients With PTSD Completed NCT01325168 Phase 4 syntocinon nasal spray;placebo nasal spray
31 A Pilot Study to Assess the Effects of Doxazosin on Polysomnography in PTSD Completed NCT01959022 Phase 4 Doxazosin XL
32 A Double-blind, Placebo-controlled Randomized Trial of Vilazodone in the Treatment of Posttraumatic Stress Disorder Completed NCT01715519 Phase 4 Treatment (Viibryd)
33 The Treatment of Traumatised Refugees With Sertraline Versus Venlafaxine in Combination With Psychotherapy - a Randomised Clinical Study Completed NCT01569685 Phase 4 Venlafaxine;Sertraline
34 Combined Mirtazapine and Selective Serotonin Reuptake Inhibitor (SSRI) Treatment of Post-traumatic Stress Disorder (PTSD) Completed NCT01178671 Phase 4 Mirtazapine;Sertraline
35 Treatment of Sleep Disturbances in Trauma-affected Refugees: A Randomised Controlled Trial Completed NCT02761161 Phase 4 Mianserin
36 Efficacy of an SSRI in Acute Stress Disorder and PTSD Completed NCT00050804 Phase 4 sertraline
37 Topiramate Treatment of Alcohol Use Disorders in Veterans With Post Traumatic Stress Disorder (PTSD): A Pilot Controlled Trial of Augmentation Therapy Completed NCT01087736 Phase 4 Topiramate
38 Minocycline for Treatment of Posttraumatic Stress Disorder in Veterans Completed NCT03340350 Phase 4 Minocycline
39 Interest for a Relative of Seeing Himself Proposing to Witness Resuscitation of a Family Member Victim of a Cardiac Arrest Completed NCT01009606 Phase 4
40 Preventing Post-Operative Delirium in Pneumonectomy, Esophagectomy and Thoracotomy Patients Completed NCT02213900 Phase 4 Haloperidol;Placebo
41 Treatment for Psychogenic Nonepileptic Seizures: A Pilot, 12 Week, Prospective, Randomized, Placebo-controlled, Double-blind, Clinical Trial of Sertraline in the Treatment of Comorbid Psychiatric Disorders in NES Completed NCT00159965 Phase 4 sertraline;placebo
42 An Open Label Pilot Study of Adjunctive Asenapine for the Treatment of Posttraumatic Stress Disorder Completed NCT01587118 Phase 4 Adjunctive asenapine
43 Secondary Prevention With Paroxetine vs. Placebo in Subthreshold Posttraumatic Stress Disorder (PTSD) Completed NCT00560612 Phase 4 Paroxetine;Placebo
44 A Controlled Trial of Topiramate Treatment for Alcohol Dependence in Veterans With PTSD Completed NCT01749215 Phase 4 Topiramate;placebo
45 An Open-Label Trial of Memantine for Cognitive Impairment in Patients With Post-Traumatic Stress Disorder Completed NCT02258828 Phase 4 Memantine
46 Effects of Hydrocortisone and D-Cycloserine on Fear Extinction in Veterans With Posttraumatic Stress Disorder Completed NCT00674570 Phase 4 Hydrocortisone;D-Cycloserine;Placebo
47 Combination Treatment for PTSD After the WTC Attack Completed NCT01130103 Phase 4 Paroxetine
48 Neural Circuits in Women With Abuse and Posttraumatic Stress Disorder Completed NCT01681849 Phase 4 Placebo;Paroxetine
49 A Randomized, Placebo-Controlled Trial of Quetiapine (Seroquel) Monotherapy in the Treatment of PTSD Completed NCT00237393 Phase 4 Quetiapine;Placebo
50 Randomized Clinical Trial to Study the Topiramate Efficacy for Posttraumatic Disorder Treatment Completed NCT00725920 Phase 4 Topiramate;placebo control group

Search NIH Clinical Center for Post-Traumatic Stress Disorder

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Carbamazepine
Lithium
Lithium Aspartate
Lithium Carbonate
lithium citrate
nefazodone
Paroxetine
Paroxetine Hydrochloride
Sertraline
Sertraline Hydrochloride
Tranylcypromine
Tranylcypromine sulfate

Cochrane evidence based reviews: stress disorders, post-traumatic

Genetic Tests for Post-Traumatic Stress Disorder

Genetic tests related to Post-Traumatic Stress Disorder:

# Genetic test Affiliating Genes
1 Post-Traumatic Stress Disorder 29

Anatomical Context for Post-Traumatic Stress Disorder

MalaCards organs/tissues related to Post-Traumatic Stress Disorder:

40
Brain, Eye, Testes, Amygdala, Heart, Cortex, Prefrontal Cortex

Publications for Post-Traumatic Stress Disorder

Articles related to Post-Traumatic Stress Disorder:

(show top 50) (show all 10558)
# Title Authors PMID Year
1
Military Service-Related Post-traumatic Stress Disorder: Finding a Way Home. 61 42
31703776 2019
2
Music Therapy With Military Populations: A Scoping Review. 61 42
31696919 2019
3
Biological Citizenship - A 53-Year-Old Man with Schizoaffective Disorder and PTSD Applying for Supplemental Security Income. 42
31747725 2019
4
The D2 dopamine receptor gene variant C957T affects human fear conditioning and aversive priming. 54 61
19900188 2010
5
Candidate-gene approach in fibromyalgia syndrome: association analysis of the genes encoding substance P receptor, dopamine transporter and alpha1-antitrypsin. 54 61
20074437 2009
6
The DRD2 gene 957C>T polymorphism is associated with posttraumatic stress disorder in war veterans. 54 61
18833581 2009
7
Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorder. 54 61
18213623 2008
8
Effects of trauma-related audiovisual stimulation on cerebrospinal fluid norepinephrine and corticotropin-releasing hormone concentrations in post-traumatic stress disorder. 54 61
18295412 2008
9
Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model. 54 61
17644267 2007
10
No association between the Clara cell secretory protein (CC16) gene polymorphism and personality traits. 54 61
16764982 2006
11
The D2 dopamine receptor (DRD2) gene is associated with co-morbid depression, anxiety and social dysfunction in untreated veterans with post-traumatic stress disorder. 54 61
16632165 2006
12
Expression of c-fos and BDNF mRNA in subregions of the prefrontal cortex of male and female rats after acute uncontrollable stress. 54 61
15993862 2005
13
Glucocorticoid receptor polymorphisms and post-traumatic stress disorder. 54 61
15511603 2005
14
Neurobiological characteristics of rhesus macaque abusive mothers and their relation to social and maternal behavior. 54 61
15652254 2005
15
An increased capacity for adrenal DHEA release is associated with decreased avoidance and negative mood symptoms in women with PTSD. 54 61
15199367 2004
16
Effect of topiramate on glucocorticoid receptor mediated action. 54 61
14666121 2004
17
The effects of chronic treatment with the mood stabilizers valproic acid and lithium on corticotropin-releasing factor neuronal systems. 54 61
12606697 2003
18
Cerebrospinal fluid corticotropin-releasing factor (CRF) and vasopressin concentrations predict pituitary response in the CRF stimulation test: a multiple regression analysis. 54 61
12629539 2003
19
Flow cytometric determination of glucocorticoid receptor (GCR) expression in lymphocyte subpopulations: lower quantity of GCR in patients with post-traumatic stress disorder (PTSD). 54 61
12562397 2003
20
Harmful drinking in military veterans with post-traumatic stress disorder: association with the D2 dopamine receptor A1 allele. 54 61
12217937 2002
21
Corticotropin-releasing hormone in depression and post-traumatic stress disorder. 54 61
11337099 2001
22
The DRD2 gene in psychiatric and neurological disorders and its phenotypes. 54 61
11256581 2000
23
Plasma neuropeptide Y (NPY) increases in humans in response to the alpha 2 antagonist yohimbine. 54 61
9608581 1998
24
Effects of psychological stress on serum prolyl endopeptidase and dipeptidyl peptidase IV activity in humans: higher serum prolyl endopeptidase activity is related to stress-induced anxiety. 54 61
9802123 1998
25
An open trial of moclobemide in the treatment of post-traumatic stress disorder. 54 61
9347385 1997
26
Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder. 54 61
9137116 1997
27
Persistent changes in corticotropin-releasing factor systems due to early life stress: relationship to the pathophysiology of major depression and post-traumatic stress disorder. 54 61
9230630 1997
28
Hypersensitivity of the hypothalamic-pituitary-adrenal axis to naloxone in post-traumatic stress disorder. 54 61
8392385 1993
29
Pleiotropic actions of allopregnanolone underlie therapeutic benefits in stress-related disease. 61
31879693 2020
30
Pharmacological rewriting of fear memories: A beacon for post-traumatic stress disorder. 61
31778672 2020
31
Addressing the "Myth" of Racial Trauma: Developmental and Ecological Considerations for Youth of Color. 61
31641920 2020
32
Genetic association of FKBP5 with PTSD in US service members deployed to Iraq and Afghanistan. 61
31927265 2020
33
Is the mental health profile of immigrants changing? A national-level analysis based on hospital discharges in Italy. 61
31944210 2020
34
Assaying Fear Memory Discrimination and Generalization: Methods and Concepts. 61
31995285 2020
35
Differential effects of prior stress on conditioned inhibition of fear and fear extinction. 61
31891742 2020
36
Hazardous drinking and clinical correlates among suicidal patients receiving psychiatric inpatient care at military medical settings. 61
31783246 2020
37
A syndemic of psychosocial health problems is associated with increased HIV sexual risk among Nigerian gay, bisexual, and other men who have sex with men (GBMSM). 61
31608657 2020
38
The serotonergic and alpha-1 adrenergic receptor modulator ACH-000029 ameliorates anxiety-like behavior in a post-traumatic stress disorder model. 61
31843397 2020
39
Synapse impairment associated with enhanced apoptosis in post-traumatic stress disorder. 61
31562782 2020
40
Post-traumatic stress disorder and subthreshold post-traumatic stress disorder in recent male asylum seekers: An expected but overlooked "European" epidemic. 61
31769207 2020
41
Prevalence of Post-traumatic Stress Disorder and Depression After the September 19th, 2017 Earthquake in Mexico. 61
32023505 2020
42
The association between anaphylaxis and post-traumatic stress disorder in subjects with Hymenoptera venom allergy. 61
31400478 2020
43
Akt dependent adult hippocampal neurogenesis regulates the behavioral improvement of treadmill running to mice model of post-traumatic stress disorder. 61
31759046 2020
44
Clinical Implication of Altered Inhibitory Response in Patients with Post-traumatic Stress Disorder: Electrophysiological Evidence from a Go/Nogo Task. 61
32034577 2020
45
Mediating role of post-traumatic stress disorder in post-traumatic growth in adults who experienced the 2017 Pohang earthquake. 61
31818784 2020
46
Depression, post-traumatic stress disorder, suicidality and self-harm among people who inject drugs: A systematic review and meta-analysis. 61
31874449 2020
47
Calcineurin Promotes Neuroplastic Changes in the Amygdala Associated with Weakened Cocaine-Cue Memories. 61
31862855 2020
48
Mental health conditions and the risk of chronic opioid therapy among patients with rheumatoid arthritis: a retrospective veterans affairs cohort study. 61
32036583 2020
49
Hair cortisol levels in posttraumatic stress disorder and metabolic syndrome. 61
32008379 2020
50
Psychological interventions for common mental disorders in women experiencing intimate partner violence in low-income and middle-income countries: a systematic review and meta-analysis. 61
31981539 2020

Variations for Post-Traumatic Stress Disorder

Expression for Post-Traumatic Stress Disorder

Search GEO for disease gene expression data for Post-Traumatic Stress Disorder.

Pathways for Post-Traumatic Stress Disorder

Pathways related to Post-Traumatic Stress Disorder according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.58 MAOB MAOA DRD2 COMT ADCYAP1R1 ADCYAP1
2 12.17 DRD2 BDNF ADCYAP1R1 ADCYAP1
3
Show member pathways
11.88 MAOB MAOA DRD2 BDNF
4 11.86 SLC6A4 MAOB MAOA HTR2A
5 11.77 SLC6A4 NR3C1 MAOA IL1B HTR2A BDNF
6
Show member pathways
11.55 MAOB MAOA DBH COMT
7 11.35 NR3C1 IL1B APOE
8 11.1 SLC6A4 MAOA HTR2A
9
Show member pathways
11.09 SLC6A4 MAOA IL1B DBH
10
Show member pathways
11.05 SLC6A4 MAOA COMT
11
Show member pathways
10.92 MAOA DBH COMT
12
Show member pathways
10.67 MAOB MAOA
13
Show member pathways
10.67 MAOB MAOA COMT
14
Show member pathways
10.59 ADCYAP1R1 ADCYAP1
15 10.58 MAOB MAOA COMT
16
Show member pathways
10.46 SLC6A4 MAOB MAOA DRD2 DBH COMT

GO Terms for Post-Traumatic Stress Disorder

Cellular components related to Post-Traumatic Stress Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.65 HTR2A DRD2 COMT BDNF APOE
2 axon GO:0030424 9.55 HTR2A DRD2 COMT CNR1 BDNF
3 integral component of postsynaptic membrane GO:0099055 9.13 SLC6A4 HTR2A DRD2
4 integral component of presynaptic membrane GO:0099056 8.92 SLC6A4 HTR2A DRD2 CNR1

Biological processes related to Post-Traumatic Stress Disorder according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 10.1 HTR2A DRD2 CRH CNR1 APOE ADCYAP1R1
2 positive regulation of gene expression GO:0010628 9.97 SLC6A4 IL1B CRP CRH ADCYAP1
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.87 HTR2A DRD2 APOE ADCYAP1
4 response to lipopolysaccharide GO:0032496 9.84 MAOB IL1B COMT CNR1
5 response to toxic substance GO:0009636 9.8 SLC6A4 MAOB DRD2
6 female pregnancy GO:0007565 9.79 CRH COMT ADCYAP1
7 positive regulation of neuron projection development GO:0010976 9.78 CNR1 BDNF APOE ADCYAP1
8 negative regulation of cell death GO:0060548 9.76 DRD2 CRH ADCYAP1R1
9 sensory perception of pain GO:0019233 9.72 HTR2A CNR1 ADCYAP1
10 response to drug GO:0042493 9.7 SLC6A4 MAOB HTR2A DRD2 CRH COMT
11 response to cocaine GO:0042220 9.67 DRD2 CRH CNR1
12 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IL1B APOE
13 memory GO:0007613 9.65 SLC6A4 HTR2A DBH CNR1 BDNF
14 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.64 HTR2A DRD2
15 behavioral response to ethanol GO:0048149 9.64 DRD2 DBH
16 dopamine metabolic process GO:0042417 9.63 DRD2 COMT
17 associative learning GO:0008306 9.63 DRD2 DBH CRH
18 regulation of synaptic transmission, GABAergic GO:0032228 9.62 DRD2 CNR1
19 locomotory exploration behavior GO:0035641 9.61 CRH APOE
20 positive regulation of growth hormone secretion GO:0060124 9.61 DRD2 ADCYAP1
21 activation of phospholipase C activity GO:0007202 9.61 HTR2A BDNF ADCYAP1R1
22 negative regulation of potassium ion transport GO:0043267 9.6 HTR2A ADCYAP1
23 catecholamine metabolic process GO:0006584 9.59 MAOA COMT
24 response to pain GO:0048265 9.58 DBH CRH COMT
25 positive regulation of cAMP-mediated signaling GO:0043950 9.54 CRH ADCYAP1R1 ADCYAP1
26 positive regulation of fever generation GO:0031622 9.52 IL1B CNR1
27 negative regulation of dopamine secretion GO:0033602 9.51 DRD2 CNR1
28 neurotransmitter catabolic process GO:0042135 9.5 MAOB MAOA COMT
29 response to ethanol GO:0045471 9.43 MAOB DRD2 CRH CNR1 ADCYAP1R1 ADCYAP1
30 dopamine catabolic process GO:0042420 8.92 MAOB MAOA DBH COMT

Molecular functions related to Post-Traumatic Stress Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.58 SLC6A4 PREP NR3C1 MAOB MAOA IL1B
2 drug binding GO:0008144 9.33 HTR2A DRD2 CNR1
3 serotonin binding GO:0051378 9.26 SLC6A4 HTR2A
4 primary amine oxidase activity GO:0008131 8.96 MAOB MAOA

Sources for Post-Traumatic Stress Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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