PTSD
MCID: PST028
MIFTS: 60

Post-Traumatic Stress Disorder (PTSD)

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Post-Traumatic Stress Disorder

MalaCards integrated aliases for Post-Traumatic Stress Disorder:

Name: Post-Traumatic Stress Disorder 12 29 43 15 17 72 33
Stress Disorders, Post-Traumatic 44
Post Traumatic Stress Disorder 75
Posttraumatic Stress Disorder 15
Traumatic Neurosis 12
Ptsd 48

Classifications:



External Ids:

Disease Ontology 12 DOID:2055
ICD9CM 35 309.81
MeSH 44 D013313
NCIt 50 C3389
SNOMED-CT 68 47505003
ICD10 33 F43.1 F43.10
UMLS 72 C0038436

Summaries for Post-Traumatic Stress Disorder

MedlinePlus : 43 Post-traumatic stress disorder (PTSD) is a real illness. You can get PTSD after living through or seeing a traumatic event, such as war, a hurricane, sexual assault, physical abuse, or a bad accident. PTSD makes you feel stressed and afraid after the danger is over. It affects your life and the people around you. PTSD can cause problems like Flashbacks, or feeling like the event is happening again Trouble sleeping or nightmares Feeling alone Angry outbursts Feeling worried, guilty, or sad PTSD starts at different times for different people. Signs of PTSD may start soon after a frightening event and then continue. Other people develop new or more severe signs months or even years later. PTSD can happen to anyone, even children. Treatment may include talk therapy, medicines, or both. Treatment might take 6 to 12 weeks. For some people, it takes longer. NIH: National Institute of Mental Health

MalaCards based summary : Post-Traumatic Stress Disorder, also known as stress disorders, post-traumatic, is related to traumatic brain injury and brain injury, and has symptoms including nervousness An important gene associated with Post-Traumatic Stress Disorder is LINC01090 (Long Intergenic Non-Protein Coding RNA 1090), and among its related pathways/superpathways are Circadian entrainment and Amphetamine addiction. The drugs Tramadol and Diazepam have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related phenotypes are homeostasis/metabolism and behavior/neurological

Disease Ontology : 12 An anxiety disorder which results from a traumatic experience that results in psychological trauma.

Wikipedia : 75 Posttraumatic stress disorder (PTSD)[note 1] is a mental disorder that can develop after a person is... more...

Related Diseases for Post-Traumatic Stress Disorder

Diseases related to Post-Traumatic Stress Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 468)
# Related Disease Score Top Affiliating Genes
1 traumatic brain injury 33.3 DRD2 COMT BDNF APOE
2 brain injury 31.8 DRD2 COMT BDNF APOE
3 anxiety 31.5 SLC6A4 NR3C1 MAOA HTR2A CRH COMT
4 avoidant personality disorder 31.0 SLC6A4 MAOA
5 substance abuse 30.9 SLC6A4 MAOA DRD2 COMT BDNF
6 fibromyalgia 30.9 SLC6A4 HTR2A CRH COMT
7 social phobia 30.8 SLC6A4 MAOA DRD2
8 depression 30.8 SLC6A4 NR3C1 MAOA HTR2A CRH BDNF
9 phobia, specific 30.7 MAOA COMT
10 bipolar disorder 30.7 SLC6A4 HTR2A DRD2 COMT BDNF
11 alexithymia 30.6 SLC6A4 DRD2 CRP COMT
12 amnestic disorder 30.5 PREP CNR1 BDNF
13 panic disorder 30.5 SLC6A4 MAOA HTR2A CRH COMT
14 conduct disorder 30.5 SLC6A4 MAOA DRD2 COMT
15 dysthymic disorder 30.5 SLC6A4 MAOA HTR2A
16 phobic disorder 30.5 SLC6A4 MAOA COMT
17 substance-induced psychosis 30.5 HTR2A DRD2
18 sleep apnea 30.5 IL1B HTR2A CRP APOE
19 bulimia nervosa 30.4 SLC6A4 HTR2A COMT BDNF
20 cannabis abuse 30.4 CNR1 BDNF
21 personality disorder 30.4 SLC6A4 MAOA HTR2A DRD2 COMT BDNF
22 arteries, anomalies of 30.3 IL1B CRP APOE
23 substance dependence 30.3 SLC6A4 MAOA DRD2 CNR1 BDNF
24 postpartum depression 30.3 SLC6A4 MAOA CRH COMT BDNF
25 drug dependence 30.2 SLC6A4 DRD2 CRH CNR1 BDNF
26 borderline personality disorder 30.2 SLC6A4 NR3C1 MAOA HTR2A COMT BDNF
27 bipolar i disorder 30.2 SLC6A4 HTR2A COMT BDNF
28 eating disorder 30.2 SLC6A4 DRD2 CRH COMT CNR1 BDNF
29 generalized anxiety disorder 30.2 SLC6A4 MAOA HTR2A DRD2 COMT BDNF
30 mental depression 30.1 SLC6A4 NR3C1 MAOA HTR2A FKBP5 CRH
31 anorexia nervosa 30.1 SLC6A4 HTR2A CRH COMT BDNF
32 psychotic disorder 30.1 SLC6A4 MAOB HTR2A DRD2 COMT BDNF
33 periodic limb movement disorder 30.0 SLC6A4 HTR2A DRD2
34 oppositional defiant disorder 30.0 SLC6A4 MAOA DRD2 COMT
35 cannabis dependence 30.0 FAAH COMT CNR1
36 somatoform disorder 29.9 IL1B FAAH COMT
37 obsessive-compulsive disorder 29.9 SLC6A4 MAOA HTR2A DRD2 CRH COMT
38 antisocial personality disorder 29.8 SLC6A4 MAOB MAOA DRD2 COMT
39 tobacco addiction 29.8 SLC6A4 MAOA HTR2A DRD2 COMT
40 schizoaffective disorder 29.8 SLC6A4 HTR2A DRD2 COMT BDNF
41 pheochromocytoma 29.7 MAOB CRH COMT ADCYAP1
42 paranoid schizophrenia 29.7 SLC6A4 MAOA HTR2A COMT BDNF
43 multiple sclerosis 29.5 IL1B CNR1 BDNF APOE
44 gastrointestinal system disease 29.5 IL1B CRP CRH
45 alzheimer disease 29.5 SLC6A4 MAOB IL1B CRH BDNF APOE
46 migraine with or without aura 1 29.5 SLC6A4 MAOA HTR2A DRD2 COMT CNR1
47 polysubstance abuse 29.4 FAAH DRD2 COMT CNR1
48 serotonin syndrome 29.4 SLC6A4 MAOB MAOA HTR2A
49 chronic fatigue syndrome 29.4 SLC6A4 NR3C1 MAOA IL1B HTR2A CRH
50 attention deficit-hyperactivity disorder 29.3 SLC6A4 MAOB MAOA HTR2A DRD2 COMT

Comorbidity relations with Post-Traumatic Stress Disorder via Phenotypic Disease Network (PDN):


Anxiety Dysthymic Disorder
Major Depressive Disorder

Graphical network of the top 20 diseases related to Post-Traumatic Stress Disorder:



Diseases related to Post-Traumatic Stress Disorder

Symptoms & Phenotypes for Post-Traumatic Stress Disorder

UMLS symptoms related to Post-Traumatic Stress Disorder:


nervousness

MGI Mouse Phenotypes related to Post-Traumatic Stress Disorder:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.45 ADCYAP1 ADCYAP1R1 APOE BDNF CNR1 COMT
2 behavior/neurological MP:0005386 10.43 ADCYAP1 ADCYAP1R1 APOE BDNF CNR1 COMT
3 growth/size/body region MP:0005378 10.25 ADCYAP1 ADCYAP1R1 APOE BDNF CNR1 CRH
4 mortality/aging MP:0010768 10.25 ADCYAP1 ADCYAP1R1 APOE BDNF CNR1 DRD2
5 nervous system MP:0003631 10.24 ADCYAP1 ADCYAP1R1 APOE BDNF CNR1 COMT
6 immune system MP:0005387 10.18 ADCYAP1 ADCYAP1R1 APOE COMT CRH CRP
7 integument MP:0010771 10.11 APOE BDNF CNR1 CRH DRD2 FAAH
8 adipose tissue MP:0005375 10.08 ADCYAP1 APOE CNR1 CRH DRD2 NR3C1
9 muscle MP:0005369 9.95 ADCYAP1 APOE DRD2 FAAH HTR2A NR3C1
10 no phenotypic analysis MP:0003012 9.92 ADCYAP1 ADCYAP1R1 APOE BDNF CNR1 CRH
11 normal MP:0002873 9.91 ADCYAP1R1 BDNF CNR1 CRH DRD2 FAAH
12 renal/urinary system MP:0005367 9.76 APOE COMT CRH DRD2 FKBP5 MAOB
13 reproductive system MP:0005389 9.61 ADCYAP1 ADCYAP1R1 APOE BDNF CNR1 COMT
14 taste/olfaction MP:0005394 8.92 APOE BDNF CNR1 DRD2

Drugs & Therapeutics for Post-Traumatic Stress Disorder

Drugs for Post-Traumatic Stress Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 370)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
2
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
3
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
4
Cycloserine Approved Phase 4 68-41-7 6234 401
5
Lamotrigine Approved, Investigational Phase 4 84057-84-1 3878
6
Mifepristone Approved, Investigational Phase 4 84371-65-3 55245
7
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
8
Mianserin Approved, Investigational Phase 4 24219-97-4 4184
9
Mirtazapine Approved Phase 4 61337-67-5, 85650-52-8 4205
10
Histamine Approved, Investigational Phase 4 51-45-6 774
11
Dronabinol Approved, Illicit Phase 4 1972-08-3 16078
12
Haloperidol Approved Phase 4 52-86-8 3559
13
Asenapine Approved Phase 4 65576-45-6, 85650-56-2 3001386
14
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
15
Memantine Approved, Investigational Phase 4 19982-08-2 4054
16
Levodopa Approved Phase 4 59-92-7 6047
17
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
18
Citalopram Approved Phase 4 59729-33-8 2771
19
Vortioxetine Approved, Investigational Phase 4 508233-74-7 9966051
20
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
21
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
22
Polyestradiol phosphate Approved Phase 4 28014-46-2
23
Fluvoxamine Approved, Investigational Phase 4 54739-18-3 3404 5324346
24
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
25
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
26
Prazosin Approved Phase 4 19216-56-9 4893
27
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
28
Promethazine Approved, Investigational Phase 4 60-87-7 4927
29
Suvorexant Approved, Investigational Phase 4 1030377-33-3
30
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
31
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
32
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
33
Carbon monoxide Approved, Investigational Phase 4 630-08-0 281
34
Sodium citrate Approved, Investigational Phase 4 68-04-2
35
Sertraline Approved Phase 4 79617-96-2 68617
36
Propranolol Approved, Investigational Phase 4 525-66-6 4946
37
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
38
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
39
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
40
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
41
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
42 Olive Phase 4
43 Protective Agents Phase 4
44 Analgesics, Non-Narcotic Phase 4
45 Antiparkinson Agents Phase 4
46 Autonomic Agents Phase 4
47 Quetiapine Fumarate Phase 4 111974-72-2
48 Anti-Infective Agents Phase 4
49 calcium channel blockers Phase 4
50 Calcium, Dietary Phase 4

Interventional clinical trials:

(show top 50) (show all 1567)
# Name Status NCT ID Phase Drugs
1 A Prospective Double Blind Randomized Placebo Controlled Trial of Repetitive Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder Unknown status NCT00134446 Phase 4
2 A Double-Blind, Placebo-Controlled, Flexible-Dose Pilot Clinical Trial of Once-Daily Extended-Release Tramadol for the Treatment of PTSD Unknown status NCT01517711 Phase 4 Tramadol;Placebo
3 The Effect of 21-Days Intranasal Oxytocin on Clinical Symptoms and Social Function in Patients With Post Traumatic Stress Disorder (PTSD), a Randomized Controled Trail Unknown status NCT02336568 Phase 4 Oxytoine;PLACEBO
4 Predictors of Treatment Response to Fluoxetine in PTSD Following a Recent History of War Zone Stress Exposure Unknown status NCT00633685 Phase 4 Fluoxetine;Placebo
5 Treatment of Sleep Disturbances in Trauma-affected Refugees: A Randomised Controlled Trial Unknown status NCT02761161 Phase 4 Mianserin
6 A Randomized Cross Over Trial of Two Treatments for Obstructive Sleep Apnea in Veterans With Post Traumatic Stress Disorder Unknown status NCT01535586 Phase 4
7 Posttraumatic Stress Disorder and Affective Functioning: A Test of the Potentially Normalizing Effects of Oxytocin Unknown status NCT02546570 Phase 4 Oxytocin;Placebo
8 Early Pharmacological Intervention With Diazepam in the Emergency Room Setting to Prevent Posttraumatic Stress Disorder (PTSD). Unknown status NCT01221883 Phase 4 Diazepam
9 Double Blind, Placebo-Controlled Trial of THC as add-on Therapy for PTSD Unknown status NCT00965809 Phase 4 Tetrahydrocannabinol
10 Neurofunctional Markers of SSRI Treatment Response in PTSD Completed NCT00700999 Phase 4 Paroxetine
11 Eszopiclone for the Treatment of PTSD Completed NCT01605253 Phase 4 Eszopiclone;Placebo
12 Randomized Trial of Sertraline, Prolonged Exposure, and Their Combination for Post-traumatic Stress Disorder (PTSD) in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF). Completed NCT01524133 Phase 4 Sertraline
13 Naltrexone and Cognitive-Behavioral Therapy for Patients With Alcoholism and Post-Traumatic Stress Disorder Completed NCT00006489 Phase 4 Naltrexone;Placebo
14 Reducing Suicidal Ideation Through Treatment of Nightmares-PTSD Completed NCT02199652 Phase 4 Prazosin;Placebo
15 Geodon (Ziprasidone) for Posttraumatic Stress Disorder Completed NCT00208208 Phase 4 Ziprasidone
16 Risperidone Monotherapy in the Treatment of PTSD in Women Survivors of Domestic Abuse and Rape Trauma: a Double-Blind, Placebo Controlled, Randomized Clinical Trial Completed NCT00208182 Phase 4 Risperidone
17 Topiramate in the Treatment of Post Traumatic Stress Disorder (PTSD) Completed NCT00203463 Phase 4 topiramate
18 Effects of Escitalopram on Autonomic Reactivity in Post Traumatic Stress Disorder Among Veterans of Operation Enduring Freedom and Iraqi Freedom (OEF/OIF) Completed NCT01271244 Phase 4 Escitalopram
19 A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Determine the Efficacy and Safety of Topiramate in the Treatment of Posttraumatic Stress Disorder in Civilians Completed NCT00208130 Phase 4 Topiramate
20 Coordinated Anxiety Learning and Management (CALM): Improving Primary Care Anxiety Outcomes Completed NCT00347269 Phase 4 Psychotropic medication optimization
21 Eszopiclone for Sleep Disturbance and Nightmares in Post-Traumatic Stress Disorder Completed NCT00120250 Phase 4 Eszopiclone
22 Developing Memory Reconsolidation Blockers as Novel PTSD Treatments Completed NCT01490697 Phase 4 Mifepristone;d-Cycloserine;Placebo-matching Mifepristone;Placebo-matching d-Cycloserine (DCS)
23 The Outcome of Treatment of Traumatised Refugees With Trauma-Focused Cognitive Behavioural Therapy and / or Antidepressants - a Randomised Controlled Trial Completed NCT00917397 Phase 4 Sertraline
24 Cognitive Behavioral Therapy vs. Sertraline in the Treatment of Post Traumatic Stress Disorder Completed NCT00391430 Phase 4 Sertraline
25 Telemedicine Outreach for Post Traumatic Stress in CBOCs Completed NCT00821678 Phase 4
26 Atomoxetine in Comorbid ADHD/PTSD: A Pilot, Placebo-Controlled Feasibility Study Completed NCT02287038 Phase 4 Atomoxetine 80 MG
27 The Effect of Intranasal Oxytocin on Emphatic Abilities in Patients With PTSD Completed NCT01325168 Phase 4 syntocinon nasal spray;placebo nasal spray
28 A Pilot Study to Assess the Effects of Doxazosin on Polysomnography in PTSD Completed NCT01959022 Phase 4 Doxazosin XL
29 A Double-blind, Placebo-controlled Randomized Trial of Vilazodone in the Treatment of Posttraumatic Stress Disorder Completed NCT01715519 Phase 4 Treatment (Viibryd)
30 The Treatment of Traumatised Refugees With Sertraline Versus Venlafaxine in Combination With Psychotherapy - a Randomised Clinical Study Completed NCT01569685 Phase 4 Venlafaxine;Sertraline
31 Combined Mirtazapine and Selective Serotonin Reuptake Inhibitor (SSRI) Treatment of Post-traumatic Stress Disorder (PTSD) Completed NCT01178671 Phase 4 Mirtazapine;Sertraline
32 Efficacy of an SSRI in Acute Stress Disorder and PTSD Completed NCT00050804 Phase 4 sertraline
33 Topiramate Treatment of Alcohol Use Disorders in Veterans With Post Traumatic Stress Disorder (PTSD): A Pilot Controlled Trial of Augmentation Therapy Completed NCT01087736 Phase 4 Topiramate
34 Interest for a Relative of Seeing Himself Proposing to Witness Resuscitation of a Family Member Victim of a Cardiac Arrest Completed NCT01009606 Phase 4
35 Preventing Post-Operative Delirium in Pneumonectomy, Esophagectomy and Thoracotomy Patients Completed NCT02213900 Phase 4 Haloperidol;Placebo
36 An Open Label Pilot Study of Adjunctive Asenapine for the Treatment of Posttraumatic Stress Disorder Completed NCT01587118 Phase 4 Adjunctive asenapine
37 Secondary Prevention With Paroxetine vs. Placebo in Subthreshold Posttraumatic Stress Disorder (PTSD) Completed NCT00560612 Phase 4 Paroxetine;Placebo
38 Minocycline for Treatment of Posttraumatic Stress Disorder in Veterans Completed NCT03340350 Phase 4 Minocycline
39 A Controlled Trial of Topiramate Treatment for Alcohol Dependence in Veterans With PTSD Completed NCT01749215 Phase 4 Topiramate;placebo
40 An Open-Label Trial of Memantine for Cognitive Impairment in Patients With Post-Traumatic Stress Disorder Completed NCT02258828 Phase 4 Memantine
41 Effects of Hydrocortisone and D-Cycloserine on Fear Extinction in Veterans With Posttraumatic Stress Disorder Completed NCT00674570 Phase 4 Hydrocortisone;D-Cycloserine;Placebo
42 Combination Treatment for PTSD After the WTC Attack Completed NCT01130103 Phase 4 Paroxetine
43 Neural Circuits in Women With Abuse and Posttraumatic Stress Disorder Completed NCT01681849 Phase 4 Placebo;Paroxetine
44 A Randomized, Placebo-Controlled Trial of Quetiapine (Seroquel) Monotherapy in the Treatment of PTSD Completed NCT00237393 Phase 4 Quetiapine;Placebo
45 Randomized Clinical Trial to Study the Topiramate Efficacy for Posttraumatic Disorder Treatment Completed NCT00725920 Phase 4 Topiramate;placebo control group
46 Effects of Paxil CR on Neural Circuits in PTSD Completed NCT00672776 Phase 4 paroxetine;placebo
47 Aripiprazole (Abilify) Therapy for Reducing Comorbid Substance Abuse Completed NCT00208169 Phase 4 Aripiprazole
48 A Double-Blind Placebo-Controlled Trial of Prazosin for the Treatment of Alcohol Dependence Completed NCT00167687 Phase 4 prazosin
49 Dopamine Enhancement of Fear Extinction Learning in PTSD (1R21MH108753) Completed NCT02560389 Phase 4 Placebo;Levodopa
50 A Psychophysiologic Study of Weakening Traumatic Combat Memories With Post-Reactivation Propranolol Completed NCT00709735 Phase 4 Propranolol;Placebo

Search NIH Clinical Center for Post-Traumatic Stress Disorder

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Carbamazepine
Citalopram
Escitalopram
Imipramine
Lithium
Lithium Aspartate
Lithium Carbonate
lithium citrate
nefazodone
Olanzapine
Paroxetine
Paroxetine
Paroxetine Hydrochloride
Quetiapine
Risperidone
Sertraline
Sertraline
Sertraline Hydrochloride
Tranylcypromine
Tranylcypromine sulfate

Cochrane evidence based reviews: stress disorders, post-traumatic

Genetic Tests for Post-Traumatic Stress Disorder

Genetic tests related to Post-Traumatic Stress Disorder:

# Genetic test Affiliating Genes
1 Post-Traumatic Stress Disorder 29

Anatomical Context for Post-Traumatic Stress Disorder

MalaCards organs/tissues related to Post-Traumatic Stress Disorder:

41
Brain, Eye, Testes, Amygdala, Cortex, Heart, Prefrontal Cortex

Publications for Post-Traumatic Stress Disorder

Articles related to Post-Traumatic Stress Disorder:

(show top 50) (show all 10059)
# Title Authors PMID Year
1
Post-traumatic stress disorder in living donors after pediatric liver transplantation: A cross-sectional investigation study. 38 17
31096459 2019
2
Effect of an ICU Diary on Posttraumatic Stress Disorder Symptoms Among Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial. 17
31310299 2019
3
Using Speech Markers to Diagnose PTSD. 17
31184717 2019
4
The D2 dopamine receptor gene variant C957T affects human fear conditioning and aversive priming. 9 38
19900188 2010
5
Candidate-gene approach in fibromyalgia syndrome: association analysis of the genes encoding substance P receptor, dopamine transporter and alpha1-antitrypsin. 9 38
20074437 2009
6
The DRD2 gene 957C>T polymorphism is associated with posttraumatic stress disorder in war veterans. 9 38
18833581 2009
7
Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorder. 9 38
18213623 2008
8
Effects of trauma-related audiovisual stimulation on cerebrospinal fluid norepinephrine and corticotropin-releasing hormone concentrations in post-traumatic stress disorder. 9 38
18295412 2008
9
Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model. 9 38
17644267 2007
10
No association between the Clara cell secretory protein (CC16) gene polymorphism and personality traits. 9 38
16764982 2006
11
The D2 dopamine receptor (DRD2) gene is associated with co-morbid depression, anxiety and social dysfunction in untreated veterans with post-traumatic stress disorder. 9 38
16632165 2006
12
Expression of c-fos and BDNF mRNA in subregions of the prefrontal cortex of male and female rats after acute uncontrollable stress. 9 38
15993862 2005
13
Glucocorticoid receptor polymorphisms and post-traumatic stress disorder. 9 38
15511603 2005
14
Neurobiological characteristics of rhesus macaque abusive mothers and their relation to social and maternal behavior. 9 38
15652254 2005
15
An increased capacity for adrenal DHEA release is associated with decreased avoidance and negative mood symptoms in women with PTSD. 9 38
15199367 2004
16
Effect of topiramate on glucocorticoid receptor mediated action. 9 38
14666121 2004
17
The effects of chronic treatment with the mood stabilizers valproic acid and lithium on corticotropin-releasing factor neuronal systems. 9 38
12606697 2003
18
Cerebrospinal fluid corticotropin-releasing factor (CRF) and vasopressin concentrations predict pituitary response in the CRF stimulation test: a multiple regression analysis. 9 38
12629539 2003
19
Flow cytometric determination of glucocorticoid receptor (GCR) expression in lymphocyte subpopulations: lower quantity of GCR in patients with post-traumatic stress disorder (PTSD). 9 38
12562397 2003
20
Harmful drinking in military veterans with post-traumatic stress disorder: association with the D2 dopamine receptor A1 allele. 9 38
12217937 2002
21
Corticotropin-releasing hormone in depression and post-traumatic stress disorder. 9 38
11337099 2001
22
The DRD2 gene in psychiatric and neurological disorders and its phenotypes. 9 38
11256581 2000
23
Effects of psychological stress on serum prolyl endopeptidase and dipeptidyl peptidase IV activity in humans: higher serum prolyl endopeptidase activity is related to stress-induced anxiety. 9 38
9802123 1998
24
Plasma neuropeptide Y (NPY) increases in humans in response to the alpha 2 antagonist yohimbine. 9 38
9608581 1998
25
An open trial of moclobemide in the treatment of post-traumatic stress disorder. 9 38
9347385 1997
26
Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder. 9 38
9137116 1997
27
Persistent changes in corticotropin-releasing factor systems due to early life stress: relationship to the pathophysiology of major depression and post-traumatic stress disorder. 9 38
9230630 1997
28
Hypersensitivity of the hypothalamic-pituitary-adrenal axis to naloxone in post-traumatic stress disorder. 9 38
8392385 1993
29
Effects of intranasal oxytocin on distraction as emotion regulation strategy in patients with post-traumatic stress disorder. 38
30554861 2019
30
HPA axis function and diurnal cortisol in post-traumatic stress disorder: A systematic review. 38
31236437 2019
31
Adult hippocampal neurogenesis for systems consolidation of memory. 38
31201874 2019
32
The blockade of the serotoninergic receptors 5-HT5A, 5-HT6 and 5-HT7 in the basolateral amygdala, but not in the hippocampus facilitate the extinction of fear memory. 38
31233821 2019
33
A syndemic of psychosocial and mental health problems in Liberia: Examining the link to transactional sex among young pregnant women. 38
31010396 2019
34
Social rhythm regularity moderates the relationship between sleep disruption and depressive symptoms in veterans with post-traumatic stress disorder and major depressive disorder. 38
31368369 2019
35
New neurons restore structural and behavioral abnormalities in a rat model of PTSD. 38
30865372 2019
36
Common pathways and communication between the brain and heart: connecting post-traumatic stress disorder and heart failure. 38
31161843 2019
37
Post-traumatic Stress Disorder Symptoms are Associated With Incident Chronic Back Pain: A Longitudinal Twin Study of Older Male Veterans. 38
30985567 2019
38
Molecular targets for the interactive effect of etazolate during post-traumatic stress disorder: Role of oxidative stress, BDNF and histones. 38
31047921 2019
39
Disempowered midwives and traumatised women: Exploring the parallel processes of care provider interaction that contribute to women developing Post Traumatic Stress Disorder (PTSD) post childbirth. 38
31154157 2019
40
Mental health disorder, pain, and pain treatment among long-term care residents: Evidence from the Minimum Data Set 3.0. 38
30404536 2019
41
Long-term social dysfunction after trauma: What is the prevalence, risk factors, and associated outcomes? 38
31104807 2019
42
How Do Patients with Mental Health Diagnoses Use Online Patient Portals? An Observational Analysis from the Veterans Health Administration. 38
31065908 2019
43
The Effects of Terrorist Attacks on Symptom Clusters of PTSD: a Comparison with Victims of Other Traumatic Events. 38
31187353 2019
44
The protective role of mentalizing: Reflective functioning as a mediator between child maltreatment, psychopathology and parental attitude in expecting parents. 38
31255871 2019
45
Structural, interpersonal, psychosocial, and behavioral risk factors for HIV acquisition among female bar workers in Dar es Salaam, Tanzania. 38
31079476 2019
46
An Examination of the Association Between Post-traumatic Growth and Stress Symptomatology in Cardiac Outpatients. 38
30317415 2019
47
Gender differences in the association of living and working conditions and the mental health of trafficking survivors. 38
31243470 2019
48
Unmet Needs of People with Serious Mental Illness: Perspectives from Certified Peer Specialists. 38
31154551 2019
49
Effects of MDMA on attention to positive social cues and pleasantness of affective touch. 38
31042696 2019
50
The effects of trauma on brain and body: A unifying role for the midbrain periaqueductal gray. 38
31254294 2019

Variations for Post-Traumatic Stress Disorder

Expression for Post-Traumatic Stress Disorder

Search GEO for disease gene expression data for Post-Traumatic Stress Disorder.

Pathways for Post-Traumatic Stress Disorder

Pathways related to Post-Traumatic Stress Disorder according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.82 MAOB MAOA FKBP5 DRD2 COMT ADCYAP1R1
2
Show member pathways
11.77 MAOB MAOA DRD2 BDNF
3 11.73 SLC6A4 MAOB MAOA HTR2A
4 11.43 SLC6A4 NR3C1 MAOA IL1B HTR2A BDNF
5 11.29 NR3C1 IL1B APOE
6
Show member pathways
11.24 SLC6A4 MAOA IL1B
7 10.94 SLC6A4 MAOA HTR2A
8
Show member pathways
10.85 SLC6A4 MAOA COMT
9
Show member pathways
10.62 MAOB MAOA
10
Show member pathways
10.54 ADCYAP1R1 ADCYAP1
11
Show member pathways
10.51 MAOB MAOA COMT
12 10.28 MAOB MAOA COMT

GO Terms for Post-Traumatic Stress Disorder

Cellular components related to Post-Traumatic Stress Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.65 HTR2A DRD2 COMT BDNF APOE
2 axon GO:0030424 9.55 HTR2A DRD2 COMT CNR1 BDNF
3 integral component of postsynaptic membrane GO:0099055 9.13 SLC6A4 HTR2A DRD2
4 cell body fiber GO:0070852 9.02 HTR2A
5 integral component of presynaptic membrane GO:0099056 8.92 SLC6A4 HTR2A DRD2 CNR1

Biological processes related to Post-Traumatic Stress Disorder according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.93 SLC6A4 IL1B CRP CRH ADCYAP1
2 positive regulation of neuron projection development GO:0010976 9.82 CNR1 APOE ADCYAP1
3 response to lipopolysaccharide GO:0032496 9.81 MAOB IL1B COMT CNR1
4 response to toxic substance GO:0009636 9.8 SLC6A4 MAOB DRD2
5 female pregnancy GO:0007565 9.79 CRH COMT ADCYAP1
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.77 HTR2A DRD2 ADCYAP1
7 negative regulation of cell death GO:0060548 9.73 DRD2 CRH ADCYAP1R1
8 sensory perception of pain GO:0019233 9.7 HTR2A CNR1 ADCYAP1
9 response to cocaine GO:0042220 9.65 DRD2 CRH CNR1
10 synaptic transmission, dopaminergic GO:0001963 9.64 DRD2 CRH
11 response to estradiol GO:0032355 9.64 SLC6A4 ADCYAP1R1
12 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.63 IL1B APOE
13 dopamine metabolic process GO:0042417 9.63 DRD2 COMT
14 regulation of synaptic transmission, GABAergic GO:0032228 9.61 DRD2 CNR1
15 locomotory exploration behavior GO:0035641 9.61 CRH APOE
16 negative regulation of potassium ion transport GO:0043267 9.59 HTR2A ADCYAP1
17 catecholamine metabolic process GO:0006584 9.58 MAOA COMT
18 positive regulation of growth hormone secretion GO:0060124 9.58 DRD2 ADCYAP1
19 activation of phospholipase C activity GO:0007202 9.58 HTR2A BDNF ADCYAP1R1
20 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.57 HTR2A DRD2
21 positive regulation of cAMP-mediated signaling GO:0043950 9.54 CRH ADCYAP1R1 ADCYAP1
22 neurotransmitter catabolic process GO:0042135 9.5 MAOB MAOA COMT
23 response to drug GO:0042493 9.5 SLC6A4 MAOB HTR2A DRD2 CRH COMT
24 positive regulation of fever generation GO:0031622 9.49 IL1B CNR1
25 negative regulation of dopamine secretion GO:0033602 9.46 DRD2 CNR1
26 memory GO:0007613 9.46 SLC6A4 HTR2A CNR1 BDNF
27 response to morphine GO:0043278 9.43 DRD2 CNR1
28 dopamine catabolic process GO:0042420 9.43 MAOB MAOA COMT
29 response to ethanol GO:0045471 9.1 MAOB DRD2 CRH CNR1 ADCYAP1R1 ADCYAP1
30 G protein-coupled receptor signaling pathway GO:0007186 10.09 HTR2A DRD2 CRH CNR1 APOE ADCYAP1R1

Molecular functions related to Post-Traumatic Stress Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serotonin binding GO:0051378 9.16 SLC6A4 HTR2A
2 drug binding GO:0008144 9.13 HTR2A DRD2 CNR1
3 primary amine oxidase activity GO:0008131 8.62 MAOB MAOA

Sources for Post-Traumatic Stress Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
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44 MeSH
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57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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