MCID: PST007
MIFTS: 30

Post-Vaccinal Encephalitis

Categories: Immune diseases, Neuronal diseases

Aliases & Classifications for Post-Vaccinal Encephalitis

MalaCards integrated aliases for Post-Vaccinal Encephalitis:

Name: Post-Vaccinal Encephalitis 12 15 72
Encephalitis Following Immunization Procedures 12
Encephalomyelitis, Acute Disseminated 44
Postvaccinal Encephalomyelitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13664
MeSH 44 D004673
SNOMED-CT 68 31367003
ICD10 33 G04.02
UMLS 72 C0751101

Summaries for Post-Vaccinal Encephalitis

MalaCards based summary : Post-Vaccinal Encephalitis, also known as encephalitis following immunization procedures, is related to allergic encephalomyelitis and demyelinating disease. An important gene associated with Post-Vaccinal Encephalitis is CEL (Carboxyl Ester Lipase), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and B Cell Development Pathways. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and skin, and related phenotype is growth/size/body region.

Related Diseases for Post-Vaccinal Encephalitis

Graphical network of the top 20 diseases related to Post-Vaccinal Encephalitis:



Diseases related to Post-Vaccinal Encephalitis

Symptoms & Phenotypes for Post-Vaccinal Encephalitis

MGI Mouse Phenotypes related to Post-Vaccinal Encephalitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.02 CD4 CEL HTRA1 MBP POMC

Drugs & Therapeutics for Post-Vaccinal Encephalitis

Drugs for Post-Vaccinal Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 4
2 Immunoglobulins Phase 4
3 Immunologic Factors Phase 4
4 Antibodies, Blocking Phase 4
5 Vaccines Phase 4
6
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
7
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
8
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
9
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
10
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
11 Hormone Antagonists Phase 3
12 Hormones Phase 3
13 Antiemetics Phase 3
14 Neuroprotective Agents Phase 3
15 Gastrointestinal Agents Phase 3
16 Anti-Inflammatory Agents Phase 3
17 Methylprednisolone Acetate Phase 3
18 Peripheral Nervous System Agents Phase 3
19 glucocorticoids Phase 3
20 Protective Agents Phase 3
21 Prednisolone acetate Phase 3
22 Autonomic Agents Phase 3
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Neutralizing Antibody Titers 6 Years After the Third Dose of Inactivated Japanese Encephalitis Vaccine and Projected Duration of Protection Completed NCT02039440 Phase 4
2 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
3 Large-scale, Multi-disciplinary Sample and Data Repository for Multiple Sclerosis and Related Demyelinating Diseases Active, not recruiting NCT00445367
4 PEDIATRIC SONICS: Pediatric Study of Neuropsychology and Imaging in CNS Demyelinating Syndromes. Not yet recruiting NCT03942952
5 Management of Acute Disseminated Encephalomyelitis in Neurology Unit of Assiut University Children Hospital Not yet recruiting NCT03284801

Search NIH Clinical Center for Post-Vaccinal Encephalitis

Cochrane evidence based reviews: encephalomyelitis, acute disseminated

Genetic Tests for Post-Vaccinal Encephalitis

Anatomical Context for Post-Vaccinal Encephalitis

MalaCards organs/tissues related to Post-Vaccinal Encephalitis:

41
Brain, Lung, Skin

Publications for Post-Vaccinal Encephalitis

Articles related to Post-Vaccinal Encephalitis:

(show top 50) (show all 80)
# Title Authors PMID Year
1
Reversible postvaccination paraneoplastic encephalomyelitis in a patient with lung adenocarcinoma. 38
20964557 2010
2
A mouse-based assay for the pre-clinical neurovirulence assessment of vaccinia virus-based smallpox vaccines. 38
19896867 2010
3
Iatrogenic concerns of the twentieth century: post-vaccinal encephalitis and spongiform encephalopathy. 38
21553697 2010
4
The origin and application of experimental autoimmune encephalomyelitis. 38
17917672 2007
5
Anticipating smallpox and monkeypox outbreaks: complications of the smallpox vaccine. 38
15335444 2004
6
Smallpox and smallpox vaccination: neurological implications. 38
12707424 2003
7
Encephalomyelitis, brain tumors, neuromuscular diseases and miscellaneous disorders. 38
11037180 2000
8
DNA vaccine encoding nucleocapsid and surface proteins of wild type canine distemper virus protects its natural host against distemper. 38
10825593 2000
9
ADEM: literature review and case report of acute psychosis presentation. 38
10669199 2000
10
[Acute disseminated encephalomyelitis]. 38
9103897 1997
11
[Guillain-Barré syndrome and acute disseminated encephalomyelitis (ADEM)]. 38
9128388 1996
12
Fatal rabies associated with extensive demyelination. 38
8442714 1993
13
Semple rabies vaccine: presence of myelin basic protein and proteolipid protein and its activity in experimental allergic encephalomyelitis. 38
2480399 1989
14
Rapid diagnosis of rabies and post-vaccinal encephalitides. 38
2894908 1988
15
Schilder's myelinoclastic diffuse sclerosis. 38
3940347 1986
16
[A highly efficient, highly purified duck embryo rabies vaccine]. 38
4089577 1985
17
Comparative analysis of the degree of specific humoral immunity, content of serum immunoglobulins and isolation of vaccinia virus in children with post-vaccinal encephalitis after smallpox vaccination. 38
6117594 1981
18
Allergic encephalitis, rabies antibodies, and the blood/brain barrier. 38
38289 1979
19
Postvaccinal encephalomyelitis without cutaneous vaccination reaction. 38
34358 1979
20
[Postvaccinal encephalitis in adult. A case with anatomo-clinical report (author's transl)]. 38
45321 1979
21
[Cases of postvaccinal encephalomyelitis after inoculation against tick-borne encephalitis]. 38
633817 1978
22
Post-vaccinal encephalitis. 38
24200 1977
23
The clinical picture of rabies in man. 38
982512 1976
24
Post-vaccinal encephalitis. Report of a case. 38
6390 1975
25
[Histopathological changes in patients with post-vaccinal encephalitis]. 38
54940 1975
26
[Pathomorphological and immunofluorescent studies of smallpox vaccine neurotropism]. 38
239507 1975
27
[Postvacccinal encephalomyelitis after protective antirabic innoculation, combined with polioencephalomyelitis (lyssa?)]. 38
702 1975
28
[On therapy of post-vaccinal encephalitis]. 38
4154396 1974
29
A virological study of post-vaccinal encephalitis. 38
4150692 1974
30
Skin reactivity and antibody response following vaccination against smallpox. 38
4150693 1974
31
[Manifestation of juvenile diabetes mellitus following postvaccinal encephalomyelitis]. 38
4150477 1973
32
[Diabetes mellitus from post-vaccinal encephalitis?]. 38
4392770 1970
33
[Post-vaccinal encephalitis in an infant with latent herpes infection]. 38
4395307 1970
34
[Contribution to the problem of allergic brain edema after variolation imitating post-vaccinal encephalitis]. 38
4390264 1969
35
[Recent views on the pathogenesis of parainfectious and post-vaccinal encephalitis]. 38
4389986 1969
36
[Contribution on the problem of allergic cerebral edema, following smallpox vaccination, that imitates post-vaccinal encephalitis]. 38
4389294 1968
37
[Rabies: prophylaxis and treatment. Apropos of a case of postvaccinal encephalomyelitis]. 38
4394863 1968
38
[Favorable course of severe post-vaccinal encephalitis under supporting therapy with helfergin (centrophenoxine)]. 38
4388772 1968
39
[Does an "asthenic" vaccination reaction lead to post-vaccinal encephalitis?]. 38
4386941 1968
40
[On the effectiveness of gamma-globulin with increased antivariolous antibody content in the treatment of post-vaccinal encephalitis]. 38
4176769 1968
41
[On the problem of postvaccinal encephalomyelitis with particular consideration of central nervous system complications after smallpox vaccination]. 38
4382466 1966
42
[Post-vaccinal encephalitis: a virologic study]. 38
4380154 1966
43
[Post-vaccinal encephalitis]. 38
4380994 1966
44
[Smallpox vaccinations and post-vaccinal encephalitis]. 38
4378496 1965
45
[Post-vaccinal encephalitis]. 38
4378642 1964
46
[Post-vaccinal encephalitis and its prophylaxis from the pediatrician's viewpoint]. 38
4157624 1964
47
[POST-VACCINAL ENCEPHALITIS. THE VIROLOGIST'S POINT OF VIEW]. 38
14156671 1964
48
[POST-VACCINAL ENCEPHALITIS. THE CLINICIAN'S POINT OF VIEW]. 38
14158918 1964
49
[POSTVACCINAL ENCEPHALOMYELITIS WITH ANTIRABIES VACCINE]. 38
14121349 1963
50
[A CASE OF FRONTAL SYNDROME WITH PARANOID COMPLICATIONS IN POST-VACCINAL ENCEPHALITIS]. 38
14091521 1963

Variations for Post-Vaccinal Encephalitis

Expression for Post-Vaccinal Encephalitis

Search GEO for disease gene expression data for Post-Vaccinal Encephalitis.

Pathways for Post-Vaccinal Encephalitis

Pathways related to Post-Vaccinal Encephalitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.32 CD40LG CD4
2 10.68 CD40LG CD4
3 10.19 CD40LG CD4

GO Terms for Post-Vaccinal Encephalitis

Cellular components related to Post-Vaccinal Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.26 POMC HTRA1 CEL CD40LG
2 cell surface GO:0009986 8.92 MBP CEL CD40LG CD4

Biological processes related to Post-Vaccinal Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane organization GO:0061024 9.16 MBP CD4
2 immune response GO:0006955 9.13 MBP CD40LG CD4
3 positive regulation of T cell proliferation GO:0042102 8.62 CD40LG CD4

Sources for Post-Vaccinal Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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