MCID: PST030
MIFTS: 33

Postcholecystectomy Syndrome

Categories: Gastrointestinal diseases

Aliases & Classifications for Postcholecystectomy Syndrome

MalaCards integrated aliases for Postcholecystectomy Syndrome:

Name: Postcholecystectomy Syndrome 12 54 43 15 17 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:9740
ICD9CM 34 576.0
MeSH 43 D017562
SNOMED-CT 67 90782003
ICD10 32 K91.5
UMLS 71 C0152099

Summaries for Postcholecystectomy Syndrome

MalaCards based summary : Postcholecystectomy Syndrome is related to cholelithiasis and biliary dyskinesia, and has symptoms including pain, postoperative, postoperative nausea and vomiting and icterus. An important gene associated with Postcholecystectomy Syndrome is GAST (Gastrin), and among its related pathways/superpathways is Gastric acid production. The drugs Pinaverium and Parasympatholytics have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and small intestine.

Wikipedia : 74 Postcholecystectomy syndrome (PCS) describes the presence of abdominal symptoms two years... more...

Related Diseases for Postcholecystectomy Syndrome

Diseases related to Postcholecystectomy Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 cholelithiasis 30.7 GAST CCK
2 biliary dyskinesia 30.6 SOBP CCK
3 duodenogastric reflux 29.7 MLN GAST CCK
4 duodenal ulcer 29.7 MLN GAST CCK
5 diarrhea 29.5 MLN GAST CCK
6 irritable bowel syndrome 29.4 MLN CCK
7 constipation 29.3 SOD1 MLN GAST CCK
8 gallbladder disease 1 10.3
9 cholecystitis 10.3
10 choledocholithiasis 10.3
11 cholestasis 10.2
12 peptic ulcer disease 10.2
13 bile reflux 10.1 GAST CCK
14 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.1
15 vascular disease 10.1
16 cholangitis 10.1
17 aneurysm 10.1
18 short bowel syndrome 10.0 GAST CCK
19 social phobia 10.0 SOD1 CCK
20 postgastrectomy syndrome 10.0 MLN GAST
21 peptic esophagitis 10.0 MLN GAST
22 esophagitis 10.0 MLN GAST
23 thyroid carcinoma, familial medullary 10.0 GAST CCK
24 menkes disease 10.0 SOD1 CCK
25 diabetic autonomic neuropathy 10.0 MLN GAST
26 hypertrophic pyloric stenosis 10.0 MLN GAST
27 pyloric stenosis 10.0 MLN GAST
28 zollinger-ellison syndrome 10.0 MLN GAST
29 pancreatic cancer 9.9
30 pancreatic agenesis 1 9.9
31 helicobacter pylori infection 9.9
32 bile duct cysts 9.9
33 ascaris lumbricoides infection 9.9
34 familial cold autoinflammatory syndrome 3 9.9
35 cholangiocarcinoma 9.9
36 angina pectoris 9.9
37 optic papillitis 9.9
38 cholecystolithiasis 9.9
39 biliary atresia 9.9
40 splenic artery aneurysm 9.9
41 sclerosing cholangitis 9.9
42 neuroma 9.9
43 pancreas disease 9.9
44 ascaridiasis 9.9
45 bladder disease 9.9
46 gastritis 9.9
47 intrahepatic cholangiocarcinoma 9.9
48 pancreatitis 9.9
49 biliary tract disease 9.9
50 congenital hepatic fibrosis 9.9

Comorbidity relations with Postcholecystectomy Syndrome via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Pancreatitis
Cholangitis

Graphical network of the top 20 diseases related to Postcholecystectomy Syndrome:



Diseases related to Postcholecystectomy Syndrome

Symptoms & Phenotypes for Postcholecystectomy Syndrome

UMLS symptoms related to Postcholecystectomy Syndrome:


pain, postoperative, postoperative nausea and vomiting, icterus

Drugs & Therapeutics for Postcholecystectomy Syndrome

Drugs for Postcholecystectomy Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pinaverium Approved Phase 4 59995-65-2
2 Parasympatholytics Phase 4
3 Anticonvulsants Phase 4
4 Hormones Phase 4
5 Calcium, Dietary Phase 4
6 Bromides Phase 4
7 calcium channel blockers Phase 4
8
Calcium Nutraceutical Phase 4 7440-70-2 271
9
Alverine Approved, Investigational 150-59-4 3678
10
Mebeverine Approved, Investigational 3625-06-7 62887

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Application of Pinaverium Bromide in the Treatment of Patients With Post-cholecystectomy Sphincter of Oddi Dysfunction (SOD): A Randomized, Controlled and Multicenter Clinical Study Unknown status NCT02833103 Phase 4 Danshu Capsules;Pinaverium Bromide
2 Effect of Rowachol on Prevention of Postcholecystectomy Syndrome After Laparoscopic Cholecystectomy Completed NCT01765465 Phase 4 Rowachol;Placebo
3 The RCT Study of Two Surgical Biliary-enteric Reconstruction Minimally Invasive Treatment of Bile Duct Dilatation Unknown status NCT03401424
4 Effectiveness of Duspatalin® (Mebeverine Hydrochloride) 200 mg b.i.d. in Patients With Post-cholecystectomy Gastrointestinal Spasm: a Post Marketing Observational Program in the Russian Federation Completed NCT02260154 Mebeverine
5 Does Cholecystectomy Increase the Esophageal Alkaline Reflux? Evaluation by Impedance-pH Technique Completed NCT01047085
6 Post-Cholecystectomy Gall Bladder Remnant and Cystic Duct Stump Stone: Surgical Pitfalls, Causes of Occurrence and Completion Cholecystectomy (Open Vs Laparoscopic) as a Safe Surgical Option of Treatment Completed NCT04329143
7 Early Versus Late Intervention After Biliary Tract Injury Post Cholecystectomy Not yet recruiting NCT04134546

Search NIH Clinical Center for Postcholecystectomy Syndrome

Cochrane evidence based reviews: postcholecystectomy syndrome

Genetic Tests for Postcholecystectomy Syndrome

Anatomical Context for Postcholecystectomy Syndrome

MalaCards organs/tissues related to Postcholecystectomy Syndrome:

40
Liver, Testes, Small Intestine, Pancreas, Colon

Publications for Postcholecystectomy Syndrome

Articles related to Postcholecystectomy Syndrome:

(show top 50) (show all 346)
# Title Authors PMID Year
1
Characterization of functional biliary pain and dyspeptic symptoms in patients with sphincter of Oddi dysfunction: effect of papillotomy. 54 61
17106935 2006
2
The efficacy of endoscopic sphincterotomy in patients with sphincter of Oddi dysfunction. 61 54
8935223 1996
3
Abnormal sphincter of Oddi response to cholecystokinin in postcholecystectomy syndrome patients with irritable bowel syndrome. The irritable sphincter. 54 61
7729279 1995
4
[A study on motility of sphincter of Oddi in postcholecystectomy syndrome]. 54 61
1914667 1991
5
Remnant Cystic Duct Disease After Cholecystectomy: A Case Series. 61
32496345 2020
6
Management of Postcholecystectomy Biliary Complications: A Narrative Review. 61
32483004 2020
7
Late postcholecystectomy Mirizzi syndrome due to a sessile gall bladder remnant calculus managed by laparoscopic completion cholecystectomy: a feasible surgical option. 61
31387861 2019
8
Acupuncture for the postcholecystectomy syndrome: Protocol for a systematic review and meta-analysis. 61
31393398 2019
9
An unusual case of postcholecystectomy syndrome. 61
30902509 2019
10
DISCHARGE AFTER ELECTIVE UNCOMPLICATED LAPAROSCOPIC CHOLECYSTECTOMY: CAN THE POSTOPERATIVE STAY BE REDUCED? 61
31168204 2018
11
Postcholecystectomy syndrome: symptom clusters after laparoscopic cholecystectomy. 61
30182019 2018
12
Symptomatic Cholelithiasis of a Remnant Gallbladder after Open Cholecystectomy. 61
29941371 2018
13
Clinical patterns of postcholecystectomy syndrome. 61
29536056 2018
14
[Splenic artery aneurysm masked by postcholecystectomy syndrome]. 61
29688213 2018
15
Post cholecystectomy syndrome need to redo laparoscopic completion surgery: A case report. 61
29247966 2018
16
[Isolated gallbladder agenesis mimicking biliary colic: A difficult preoperative diagnosis]. 61
28583777 2017
17
Factors relevant to persistent upper abdominal pain after cholecystectomy. 61
28495436 2017
18
[Aneurysm of the gastroduodenal artery in a female patient with the postcholecystectomy syndrome (a clinical case report)]. 61
28574052 2017
19
[Postcholecystectomy syndrome in children, fact or fiction?] 61
28393506 2016
20
Belching After Biliary Pancreatitis and Laparoscopic Cholecystectomy. 61
27147793 2016
21
[POSTCHOLECYSTECTOMY SYNDROME: CLASSIFICATION, THE RISK FACTORS, CRITERIA OF THE DIAGNOSIS ESTABLISHMENT, TREATMENT-DIAGNOSTIC ALGORITHM]. 61
27434946 2016
22
THE VALUE OF DEFORMATION OF THE BILE DUCTS IN THE DEVELOPMENT OF POSTCHOLECYSTECTOMY SYNDROME. 61
29889378 2016
23
Combined Endoscopic and Laparoscopic Management of Postcholecystectomy Mirizzi Syndrome from a Remnant Cystic Duct Stone: Case Report and Review of the Literature. 61
27047698 2016
24
[SIMULTANT OPERATIONS FOR BILIARY CALCULOUS DISEASE AS A METHOD OF PREVENTION OF POSTCHOLECYSTECTOMY SYNDROME]. 61
27025020 2015
25
[Diagnosis of sphincter of Oddi dysfunction in patients with postcholecystectomy syndrome from hepatobiliary scintigraphic findings]. 61
26999929 2015
26
[ENDOSCOPIC DIAGNOSIS AND PARIETAL IMPEDANCOMETRY IN THE ASSESSMENT OF CHANGES IN THE MUCOSA OF THE DUODENUMIN PATIENTS WITH SUSPICION ON POSTCHOLECYSTECTOMY SYNDROME]. 61
26415262 2015
27
[ENZYME THERAPY OF POSTCHOLECYSTECTOMY SYNDROME IN CHILDREN]. 61
26281161 2015
28
Laparoscopic remnant cholecystectomy and transcystic common bile duct exploration for gallbladder/cystic duct remnant with stones and choledocholithiasis after cholecystectomy. 61
25535723 2015
29
[Cholelithiasis: complications and rehabilitation]. 61
25675740 2014
30
Utility of endoscopic ultrasound to diagnose remnant stones in symptomatic patients after cholecystectomy. 61
24977399 2014
31
Surgical and endoscopic management of remnant cystic duct lithiasis after cholecystectomy--a case series. 61
24810238 2014
32
Gastroduodenal pathology in patients with asymptomatic gallbladder stones. 61
24895828 2014
33
[Peculiarities of performance of endoscopic transpapillary interventions in the early period after cholecystectomy]. 61
23987028 2013
34
Stump stone 6 years after cholecystectomy: a possibility. 61
23378549 2013
35
[Risk factors and mechanisms of the postcholecystectomy syndrome development in children]. 61
23951899 2013
36
[The role of pathological changes of biliopancreatoduodenal zone in development of postcholecystectomy syndrome]. 61
24933977 2013
37
[The use of endoscopic techniques in acute strangulated adhesive small bowel obstruction, proceeded under the guise of acute pancreatitis]. 61
24294790 2013
38
[Postcholecystectomy syndrome in children (case report)]. 61
23951902 2013
39
[Application of essential phospholipids in the treatment and prophylaxis of postcholecystectomy syndrome]. 61
23033778 2012
40
[Clinico-morphological characteristics of major duodenal papilla benign neoformations of patients with postcholecystectomy syndrome]. 61
22288166 2011
41
A dilated cystic duct stump as a cause of postcholecystectomy syndrome. 61
21679537 2011
42
[Efficacy of rifaximine in small intestinal bacterial overgrowth syndrome in patients after cholecystectomy]. 61
22416449 2011
43
The size of the papilla of Vater and its relation to its height in comparison with the visibility of the sphincter of Oddi before and after cholecystectomy. 61
21819738 2011
44
[Morphological features and esophago-gastroduodenal zone microbiocenose in patients with syndrome postcholecystectomic syndrome]. 61
22629772 2011
45
Dynamic changes of echogenicity and the size of the papilla of Vater before and after cholecystectomy. 61
21819739 2011
46
Biliary causes of postcholecystectomy syndrome. 61
18722735 2010
47
Post-cholecystectomy Mirizzi's syndrome: magnetic resonance cholangiopancreatography demonstration. 61
20871198 2010
48
[Changes of micellarity and lithogenicity of bile under conditions of transcutaneous electrostimulation and enterosorption in patients with obturation jaundice of nontumoral genesis]. 61
20623975 2010
49
[Clinique--pathogenetic features of postcholecystectomy syndrome in children]. 61
20405707 2010
50
Postcholecystectomy syndrome (PCS). 61
19857610 2010

Variations for Postcholecystectomy Syndrome

Expression for Postcholecystectomy Syndrome

Search GEO for disease gene expression data for Postcholecystectomy Syndrome.

Pathways for Postcholecystectomy Syndrome

Pathways related to Postcholecystectomy Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.47 GAST CCK

GO Terms for Postcholecystectomy Syndrome

Biological processes related to Postcholecystectomy Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 locomotory behavior GO:0007626 8.62 SOD1 SOBP

Molecular functions related to Postcholecystectomy Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 MLN GAST CCK

Sources for Postcholecystectomy Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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