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MCID: PST030
MIFTS: 35

Postcholecystectomy Syndrome

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Postcholecystectomy Syndrome

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MalaCards integrated aliases for Postcholecystectomy Syndrome:

Name: Postcholecystectomy Syndrome 12 55 44 15 73

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:9740
ICD10 33 K91.5
ICD9CM 35 576.0
MeSH 44 D017562
SNOMED-CT 68 90782003
UMLS 73 C0152099
Sources

Summaries for Postcholecystectomy Syndrome

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MalaCards based summary : Postcholecystectomy Syndrome is related to cholelithiasis and irritable bowel syndrome, and has symptoms including icterus, pain, postoperative and postoperative nausea and vomiting. An important gene associated with Postcholecystectomy Syndrome is SOBP (Sine Oculis Binding Protein Homolog), and among its related pathways/superpathways is Gastric acid production. The drugs Pinaverium and calcium channel blockers have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and colon.

Wikipedia : 76 Postcholecystectomy syndrome describes the presence of abdominal symptoms, two years after a... more...

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Related Diseases for Postcholecystectomy Syndrome

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Diseases related to Postcholecystectomy Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 cholelithiasis 29.8 CCK SST
2 irritable bowel syndrome 29.6 CCK MLN
3 duodenogastric reflux 28.2 CCK GAST MLN SST
4 biliary dyskinesia 10.5 CCK SOBP
5 common bile duct disease 10.5 CCK SOBP
6 steatorrhea 10.2 CCK SST
7 rasmussen encephalitis 10.2 CCK SST
8 nasal cavity adenocarcinoma 10.2 CCK GAST
9 pancreas disease 10.1 CCK SST
10 short bowel syndrome 10.1 CCK SST
11 dyspepsia 10.1 CCK SST
12 gastrointestinal neuroendocrine benign tumor 10.1 GAST SST
13 gastric neuroendocrine neoplasm 10.1 GAST SST
14 cataract 14, multiple types 10.0 CCK GAST
15 hyperinsulinemic hypoglycemia, familial, 2 10.0 GAST SST
16 vipoma 10.0 GAST SST
17 retinitis pigmentosa 40 10.0 GAST SST
18 pernicious anemia 10.0 GAST SST
19 megalencephaly 10.0 CCK SST
20 zollinger-ellison syndrome 10.0 GAST SST
21 gastrinoma 10.0 GAST SST
22 mixed ductal-endocrine carcinoma 10.0 GAST SST
23 islet cell tumor 10.0 GAST SST
24 serotonin syndrome 9.9 GAST SST
25 dystonia 1, torsion, autosomal dominant 9.8 KANTR MGAM
26 premenstrual tension 9.8 KANTR MGAM
27 atrophic gastritis 9.8 GAST SST
28 angina pectoris 9.8
29 hepatitis 9.8
30 cholangitis 9.8
31 congenital hepatic fibrosis 9.8
32 functional gastric disease 9.7 CCK MLN SST
33 acute pancreatitis 9.7 CCK SST
34 gallbladder disease 9.7 CCK MLN SST
35 pancreatic cholera 9.6 CCK GAST SST
36 duodenal gastrinoma 9.6 CCK GAST SST
37 gastroparesis 9.6 CCK GAST MLN
38 duodenal ulcer 9.6 CCK GAST SST
39 endocrine gland cancer 9.6 GAST SST
40 esophageal disease 9.6 GAST KANTR
41 gastroesophageal reflux 9.6 CCK GAST MLN
42 thyroid carcinoma, familial medullary 9.6 CCK GAST SST
43 diarrhea 9.6 CCK GAST SST
44 orthostatic intolerance 9.5 KANTR MGAM
45 functional colonic disease 9.2 KANTR MLN SST
46 colonic pseudo-obstruction 9.2 KANTR MLN SST
47 multiple endocrine neoplasia, type i 9.2 GAST SST
48 stomach disease 9.0 CCK GAST MLN SST
49 constipation 9.0 CCK GAST MLN SST
50 gastrointestinal system disease 9.0 CCK GAST MLN SST

Comorbidity relations with Postcholecystectomy Syndrome via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Pancreatitis
Cholangitis

Graphical network of the top 20 diseases related to Postcholecystectomy Syndrome:



Diseases related to Postcholecystectomy Syndrome
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Symptoms & Phenotypes for Postcholecystectomy Syndrome

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UMLS symptoms related to Postcholecystectomy Syndrome:


icterus, pain, postoperative, postoperative nausea and vomiting
Sources

Drugs & Therapeutics for Postcholecystectomy Syndrome

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Drugs for Postcholecystectomy Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pinaverium Approved Phase 4 59995-65-2
2 calcium channel blockers Phase 4
3 Parasympatholytics Phase 4
4 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
5 Anticonvulsants Phase 4
6 Autonomic Agents Phase 4
7 Bromides Phase 4
8 Calcium, Dietary Phase 4
9 Analgesics Phase 3,Not Applicable
10 Cyclooxygenase 2 Inhibitors Phase 3
11 Cyclooxygenase Inhibitors Phase 3,Not Applicable
12 Analgesics, Non-Narcotic Phase 3,Not Applicable
13 Anti-Inflammatory Agents Phase 3,Not Applicable
14 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Not Applicable
15 Antirheumatic Agents Phase 3,Not Applicable
16
Bupivacaine Approved, Investigational Not Applicable 2180-92-9, 38396-39-3 2474
17
Ketorolac Approved Not Applicable 74103-06-3, 66635-83-4 3826
18
Acetaminophen Approved Not Applicable 103-90-2 1983
19
Fentanyl Approved, Illicit, Investigational, Vet_approved Not Applicable 437-38-7 3345
20
Mebeverine Approved, Investigational 3625-06-7 62887
21
Alverine Approved, Investigational 150-59-4 3678
22
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
23
Propofol Approved, Investigational, Vet_approved Not Applicable 2078-54-8 4943
24
Diazepam Approved, Illicit, Investigational, Vet_approved Not Applicable 439-14-5 3016
25 Central Nervous System Depressants Not Applicable
26 Adjuvants, Anesthesia Not Applicable
27 Narcotics Not Applicable
28 Analgesics, Opioid Not Applicable
29 Anesthetics Not Applicable
30 Anesthetics, General Not Applicable
31 Anesthetics, Intravenous Not Applicable
32 Ketorolac Tromethamine Not Applicable
33 Antipyretics Not Applicable

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Pinaverium Bromide in Post-cholecystectomy Sphincter of Oddi Dysfunction Unknown status NCT02833103 Phase 4 Danshu Capsules;Pinaverium Bromide
2 Effect of Rowachol on Prevention of Postcholecystectomy Syndrome Completed NCT01765465 Phase 4 Rowachol;Placebo
3 A Randomized, Double-Blind Study of the Efficacy and Safety of Valdecoxib Compared to Placebo for Treatment of Post- Cholecystectomy Surgery Pain Completed NCT00661635 Phase 3 placebo;valdecoxib;valdecoxib
4 Biodegradable Biliary Stent for Post Operative Cystic Duct Leakage Withdrawn NCT00493675 Phase 1
5 Effectiveness of Duspatalin® in Patients With Post-cholecystectomy Gastrointestinal Spasm Completed NCT02260154 Mebeverine
6 Quadratus Lumborum Block vs Transversus Abdominis Plane Block for Post-cholecystectomy Analgesia Completed NCT03323684 Not Applicable Paracetamol infusion;Ketorolac analgesia;fentanyl
7 Endoscopic Treatment of Benign Biliary Strictures and Cystic Duct Leakages With a Novel Biodegradable Biliary Stent Completed NCT02353286 Not Applicable
8 From Acute to Chronic Postoperative Pain in Patients for Elective Cholecystectomy. Immunological Tests Completed NCT01546480
9 From ACute To Chronic Postoperative Pain in Patients for Elective Cholecystectomy Completed NCT01553253
10 Comparison of Two Kinds of Biliary Intestinal Reconstruction in Cholangiectasia Recruiting NCT03401424 Not Applicable
11 Post-Cholecystectomy Quality of Life Recruiting NCT03326154
12 Reconstruction of the Bile Duct With the Round Ligament Recruiting NCT03030573 Not Applicable
13 Comparing Epidural Versus General Anesthesia for LESS Cholecystectomies Enrolling by invitation NCT03247257 Not Applicable
14 Korea Surgical Quality Improvement Program Enrolling by invitation NCT02983474
15 Solo Single Incision Laparoscopic Cholecystectomy Not yet recruiting NCT03018964 Not Applicable

Search NIH Clinical Center for Postcholecystectomy Syndrome

Cochrane evidence based reviews: postcholecystectomy syndrome

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Genetic Tests for Postcholecystectomy Syndrome

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Anatomical Context for Postcholecystectomy Syndrome

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MalaCards organs/tissues related to Postcholecystectomy Syndrome:

41
Testes, Liver, Colon, Small Intestine
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Publications for Postcholecystectomy Syndrome

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Articles related to Postcholecystectomy Syndrome:

(show top 50) (show all 71)
# Title Authors Year
1
Clinical patterns of postcholecystectomy syndrome. ( 29536056 )
2018
2
THE VALUE OF DEFORMATION OF THE BILE DUCTS IN THE DEVELOPMENT OF POSTCHOLECYSTECTOMY SYNDROME. ( 29889378 )
2016
3
A dilated cystic duct stump as a cause of postcholecystectomy syndrome. ( 21679537 )
2011
4
Biliary causes of postcholecystectomy syndrome. ( 18722735 )
2010
5
Postcholecystectomy syndrome (PCS). ( 19857610 )
2010
6
Postcholecystectomy syndrome - an algorithmic approach. ( 19337637 )
2009
7
Dealing with postcholecystectomy syndrome. ( 18360221 )
2008
8
Postcholecystectomy syndrome in the laparoscopic era. ( 17004873 )
2006
9
Gallbladder remnant and cystic duct stump calculus as a cause of postcholecystectomy syndrome. ( 16512471 )
2005
10
Postcholecystectomy syndrome with special regard to children--a review. ( 15343459 )
2004
11
Congenital hepatic fibrosis in a patient with suspected postcholecystectomy syndrome: hepatobiliary scintigraphy at diagnosis and during follow-up. ( 14688604 )
2004
12
Partial obstruction of the colon caused by postoperative adhesions after cholecystectomy as a rare form of postcholecystectomy syndrome. ( 11197271 )
2001
13
Postcholecystectomy syndrome: evaluation by biliary cholescintigraphy and MR cholangiopancreatography ( 10512106 )
1999
14
Endoscopic retrograde cholangiopancreatography in postcholecystectomy syndrome. ( 10999064 )
1996
15
The postcholecystectomy syndrome. A role for duodenogastric reflux. ( 8724257 )
1996
16
The postcholecystectomy syndrome: a review. ( 19864820 )
1996
17
Abnormal sphincter of Oddi response to cholecystokinin in postcholecystectomy syndrome patients with irritable bowel syndrome. The irritable sphincter. ( 7729279 )
1995
18
Postcholecystectomy syndrome mimicking angina pectoris detected by the morphine provocation test. ( 7718981 )
1995
19
Postcholecystectomy syndrome. How to determine if the sphincter of Oddi is the cause. ( 1546015 )
1992
20
Papillitis and the postcholecystectomy syndrome. ( 1578498 )
1992
21
Effect of cisapride on symptoms and biliary drainage in patients with postcholecystectomy syndrome. ( 1947787 )
1991
22
HIDA imaging in postcholecystectomy syndrome--clinical value or romancing the stone? ( 1858750 )
1991
23
[A study on motility of sphincter of Oddi in postcholecystectomy syndrome]. ( 1914667 )
1991
24
Intestinal adhesions: an overlooked cause of the postcholecystectomy syndrome. ( 2083937 )
1990
25
Postcholecystectomy syndrome in northern India--study on the diagnostic and therapeutic role of ERCP. ( 2358168 )
1990
26
The postcholecystectomy syndrome: bile ducts as pain trigger zone. ( 3387890 )
1988
27
The postcholecystectomy syndrome: diagnostic and therapeutic strategy. ( 3317780 )
1987
28
Postcholecystectomy syndrome: evaluation using biliary scintigraphy and endoscopic retrograde cholangiopancreatography. ( 4023244 )
1985
29
Retrograde cholangiography in the postcholecystectomy syndrome. ( 7284939 )
1981
30
Endoscopic retrograde cholangiopancreatography. Its use in the evaluation of nonjaundiced patients with the postcholecystectomy syndrome. ( 7235952 )
1981
31
The cystic duct stump and the postcholecystectomy syndrome. An analysis of 54 patients subjected to ERCP. ( 7337400 )
1981
32
Endoscopy in the postcholecystectomy syndrome. ( 6107476 )
1980
33
Postcholecystectomy syndrome and its association with ampullary stenosis. ( 7362006 )
1980
34
Pathogenetic significance of bile acid metabolism in the postcholecystectomy syndrome. ( 7414633 )
1980
35
Sphincteroplasty for postcholecystectomy syndrome. ( 4854367 )
1974
36
The postcholecystectomy syndrome. ( 5148858 )
1971
37
Choledochoduodenal junction stenosis in the postcholecystectomy syndrome. ( 5700086 )
1968
38
THE PROBLEM OF THE POSTCHOLECYSTECTOMY SYNDROME WITH REFERENCE TO DAMAGED LIVER TISSUE. ( 14104382 )
1964
39
THE POSTCHOLECYSTECTOMY SYNDROME: PSYCHOGENIC AND PHYSIOLOGIC FACTORS. ( 14057015 )
1963
40
SURGICAL TREATMENT OF THE POSTCHOLECYSTECTOMY SYNDROME. ( 14043565 )
1963
41
THE POSTCHOLECYSTECTOMY SYNDROME. ( 14044991 )
1963
42
POSTCHOLECYSTECTOMY SYNDROME. ( 14075399 )
1963
43
The postcholecystectomy syndrome. ( 14039219 )
1962
44
The postcholecystectomy syndrome. The functional aspect of biliary colic persistent after cholecystectomy. ( 13887771 )
1962
45
Radiographic small intestine changes in cholelithiasis and postcholecystectomy syndrome. ( 13926184 )
1962
46
Postcholecystectomy syndrome. ( 13867865 )
1961
47
Relationship between 'eccentric contractions' of the gallbladder and the postcholecystectomy syndrome. ( 13683428 )
1961
48
Postcholecystectomy syndrome: a survey of 114 patients after biliary tract surgery. ( 13824916 )
1960
49
Postcholecystectomy syndrome. ( 13858508 )
1959
50
Postcholecystectomy syndrome; with special reference to the cystic duct remnant. ( 13512596 )
1958
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Variations for Postcholecystectomy Syndrome

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Expression for Postcholecystectomy Syndrome

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Search GEO for disease gene expression data for Postcholecystectomy Syndrome.
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Pathways for Postcholecystectomy Syndrome

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Pathways related to Postcholecystectomy Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Gastric acid production 1
9.47 CCK GAST
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GO Terms for Postcholecystectomy Syndrome

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Cellular components related to Postcholecystectomy Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 8.8 CCK SOD1 SST

Biological processes related to Postcholecystectomy Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 locomotory behavior GO:0007626 9.16 SOBP SOD1
2 response to heat GO:0009408 8.96 SOD1 SST
3 regulation of signaling receptor activity GO:0010469 8.92 CCK GAST MLN SST

Molecular functions related to Postcholecystectomy Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 CCK GAST MLN SST
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Sources for Postcholecystectomy Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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