MCID: PST027
MIFTS: 45

Postencephalitic Parkinson Disease

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Postencephalitic Parkinson Disease

MalaCards integrated aliases for Postencephalitic Parkinson Disease:

Name: Postencephalitic Parkinson Disease 12 15 17
Postencephalitic Parkinsonism 12 58 54 32
Parkinson Disease, Postencephalitic 43 71

Classifications:

Orphanet: 58  
Rare neurological diseases


Summaries for Postencephalitic Parkinson Disease

MalaCards based summary : Postencephalitic Parkinson Disease, also known as postencephalitic parkinsonism, is related to corticobasal degeneration and tremor. An important gene associated with Postencephalitic Parkinson Disease is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Chks in Checkpoint Regulation. Affiliated tissues include brain, eye and cortex, and related phenotypes are resting tremor and fever

Wikipedia : 74 Post-encephalitic Parkinsonism is a disease believed to be caused by a viral illness that triggers... more...

Related Diseases for Postencephalitic Parkinson Disease

Diseases related to Postencephalitic Parkinson Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 corticobasal degeneration 30.6 TARDBP MAPT LRRK2
2 tremor 30.4 SNCA PRKN MAPT LRRK2
3 striatonigral degeneration 30.3 TH SNCA SLC6A3
4 olivopontocerebellar atrophy 30.0 TH SNCA SLC6A3 MAPT
5 creutzfeldt-jakob disease 29.8 SNCA SLC6A3 PARK7 MAPT
6 multiple system atrophy 1 29.0 TH SNCA SLC6A3 PRKN MAPT MAOB
7 early-onset parkinson's disease 28.7 TH SNCA PRKN PINK1 PARK7 LRRK2
8 dystonia 28.2 TH SLC6A3 PRKN PINK1 PARK7 MAOB
9 alzheimer disease 27.9 TH TARDBP SNCA SLC6A3 PRKN PINK1
10 movement disease 27.5 TH TARDBP SNCA SLC6A3 PRKN PINK1
11 supranuclear palsy, progressive, 1 27.1 TH TARDBP SNCA SLC6A3 PRKN PINK1
12 parkinson disease, late-onset 26.7 TH SNCA SLC6A3 PRKN PINK1 PARK7
13 encephalitis 10.7
14 von economo's disease 10.7
15 hereditary late-onset parkinson disease 10.4 SNCA LRRK2
16 primary lateral sclerosis, adult, 1 10.4 SNCA MAPT
17 associative agnosia 10.4 TARDBP MAPT
18 parkinson disease, mitochondrial 10.3 PRKN LRRK2
19 coenzyme q10 deficiency, primary, 1 10.3 SNCA MAPT
20 ideomotor apraxia 10.3 TARDBP MAPT
21 semantic dementia 10.3 TARDBP MAPT
22 agraphia 10.3 TARDBP MAPT
23 oculogyric crisis 10.3
24 nominal aphasia 10.3 TARDBP MAPT
25 dysgraphia 10.3 TARDBP MAPT
26 neuronal intranuclear inclusion disease 10.3 SNCA MAPT
27 prosopagnosia 10.3 TARDBP MAPT
28 writing disorder 10.3 TARDBP MAPT
29 arteriolosclerosis 10.2 TARDBP MAPT
30 viral encephalitis 10.2
31 influenza 10.2
32 subacute delirium 10.2
33 lrrk2 parkinson disease 10.2 SNCA PRKN LRRK2
34 paroxysmal dystonia 10.2 TH SLC6A3
35 akinetic mutism 10.2 TARDBP SLC6A3 MAPT
36 mutism 10.2 TARDBP SLC6A3 MAPT
37 gerstmann-straussler disease 10.2 TARDBP SNCA MAPT
38 prion disease 10.1 TARDBP SNCA MAPT
39 delusional disorder 10.1 TH SLC6A3
40 subacute sclerosing panencephalitis 10.1
41 amnestic disorder 10.1
42 lymphatic malformation 5 10.1
43 ocular motor apraxia 10.1
44 sleep apnea 10.1
45 apraxia 10.1
46 sleeping sickness 10.1
47 muscular atrophy 10.1
48 marchiafava bignami disease 10.1
49 cocaine abuse 10.1 SNCA SLC6A3 MAOB
50 impulse control disorder 10.0 SLC6A3 MAOB

Graphical network of the top 20 diseases related to Postencephalitic Parkinson Disease:



Diseases related to Postencephalitic Parkinson Disease

Symptoms & Phenotypes for Postencephalitic Parkinson Disease

Human phenotypes related to Postencephalitic Parkinson Disease:

58 31 (show all 41)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 resting tremor 58 31 hallmark (90%) Very frequent (99-80%) HP:0002322
2 fever 58 31 frequent (33%) Frequent (79-30%) HP:0001945
3 generalized muscle weakness 58 31 frequent (33%) Frequent (79-30%) HP:0003324
4 babinski sign 58 31 frequent (33%) Frequent (79-30%) HP:0003487
5 poor speech 58 31 frequent (33%) Frequent (79-30%) HP:0002465
6 bradykinesia 58 31 frequent (33%) Frequent (79-30%) HP:0002067
7 drowsiness 58 31 frequent (33%) Frequent (79-30%) HP:0002329
8 oculogyric crisis 58 31 frequent (33%) Frequent (79-30%) HP:0010553
9 cogwheel rigidity 58 31 frequent (33%) Frequent (79-30%) HP:0002396
10 seizures 58 31 occasional (7.5%) Occasional (29-5%) HP:0001250
11 depressivity 58 31 occasional (7.5%) Occasional (29-5%) HP:0000716
12 dysarthria 58 31 occasional (7.5%) Occasional (29-5%) HP:0001260
13 dysphagia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002015
14 dysphasia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002357
15 kyphosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002808
16 vomiting 58 31 occasional (7.5%) Occasional (29-5%) HP:0002013
17 open mouth 58 31 occasional (7.5%) Occasional (29-5%) HP:0000194
18 cough 58 31 occasional (7.5%) Occasional (29-5%) HP:0012735
19 paresthesia 58 31 occasional (7.5%) Occasional (29-5%) HP:0003401
20 bilateral ptosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001488
21 headache 58 31 occasional (7.5%) Occasional (29-5%) HP:0002315
22 hyperactive deep tendon reflexes 58 31 occasional (7.5%) Occasional (29-5%) HP:0006801
23 slow saccadic eye movements 58 31 occasional (7.5%) Occasional (29-5%) HP:0000514
24 akinesia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002304
25 abnormal csf protein level 58 31 occasional (7.5%) Occasional (29-5%) HP:0025456
26 abnormal aggressive, impulsive or violent behavior 58 31 occasional (7.5%) Occasional (29-5%) HP:0006919
27 happy demeanor 58 31 occasional (7.5%) Occasional (29-5%) HP:0040082
28 csf lymphocytic pleiocytosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0200149
29 camptocormia 58 31 occasional (7.5%) Occasional (29-5%) HP:0100595
30 fixed facial expression 58 31 occasional (7.5%) Occasional (29-5%) HP:0005329
31 upgaze palsy 58 31 occasional (7.5%) Occasional (29-5%) HP:0025331
32 abnormality of the substantia nigra 58 31 occasional (7.5%) Occasional (29-5%) HP:0045007
33 auditory hallucinations 58 31 occasional (7.5%) Occasional (29-5%) HP:0008765
34 tremor by anatomical site 58 31 occasional (7.5%) Occasional (29-5%) HP:0030188
35 abnormal pyramidal sign 58 Frequent (79-30%)
36 abnormality of eye movement 58 Occasional (29-5%)
37 rigidity 58 Occasional (29-5%)
38 functional respiratory abnormality 58 Occasional (29-5%)
39 involuntary movements 58 Frequent (79-30%)
40 abnormality of higher mental function 58 Occasional (29-5%)
41 diminished movement 58 Occasional (29-5%)

MGI Mouse Phenotypes related to Postencephalitic Parkinson Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.18 CCDC62 GAK LRRK2 MAOB MAPT PARK7
2 behavior/neurological MP:0005386 10.17 GAK LRRK2 MAOB MAPT PARK7 PINK1
3 homeostasis/metabolism MP:0005376 10.11 GAK LRRK2 MAOB MAPT PARK7 PINK1
4 nervous system MP:0003631 10 GAK LRRK2 MAOB MAPT PARK7 PINK1
5 integument MP:0010771 9.87 GAK LRRK2 MAPT PRKN SLC6A3 SNCA
6 no phenotypic analysis MP:0003012 9.7 LRRK2 MAPT PINK1 PRKN SNCA TARDBP
7 normal MP:0002873 9.5 GAK LRRK2 MAPT PRKN SLC6A3 SNCA
8 taste/olfaction MP:0005394 8.92 MAPT PINK1 SLC6A3 SNCA

Drugs & Therapeutics for Postencephalitic Parkinson Disease

Search Clinical Trials , NIH Clinical Center for Postencephalitic Parkinson Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Scopolamine
Scopolamine Hydrobromide

Cochrane evidence based reviews: parkinson disease, postencephalitic

Genetic Tests for Postencephalitic Parkinson Disease

Anatomical Context for Postencephalitic Parkinson Disease

MalaCards organs/tissues related to Postencephalitic Parkinson Disease:

40
Brain, Eye, Cortex, Testes

Publications for Postencephalitic Parkinson Disease

Articles related to Postencephalitic Parkinson Disease:

(show top 50) (show all 153)
# Title Authors PMID Year
1
Phosphorylated serine422 on tau proteins is a pathological epitope found in several diseases with neurofibrillary degeneration. 54 61
10090668 1999
2
Pathological tau proteins in postencephalitic parkinsonism: comparison with Alzheimer's disease and other neurodegenerative disorders. 54 61
9307257 1997
3
Centenary of Tretiakoff's thesis on the morphology of Parkinson's disease, evolved on the grounds of encephalitis lethargica pathology. 61
31226240 2019
4
The centennial lesson of encephalitis lethargica. 61
29555881 2018
5
Von Economo's disease and postencephalitic parkinsonism responsive to carbidopa and levodopa. 61
29670352 2018
6
Powassan virus postencephalitic parkinsonism. 61
29431163 2017
7
Olfactory vector hypothesis for encephalitis lethargica. 61
28571798 2017
8
Oculogyric crises: Etiology, pathophysiology and therapeutic approaches. 61
27964831 2017
9
Psychosis in parkinsonism: an unorthodox approach. 61
28553118 2017
10
Russell Meyers (1905-1999): pioneer of functional and ultrasonic neurosurgery. 61
26871378 2016
11
Poster 319 Response of Postencephalitic Parkinsonism to Various Dopaminergic Agonists: A Case Report. 61
27673072 2016
12
Enteroviral Postencephalitic Parkinsonism With Evidence of Impaired Presynaptic Dopaminergic Function. 61
27367905 2016
13
Postencephalitic parkinsonism responsive to a dopamine agonist: A case report. 61
25899543 2015
14
Postencephalitic parkinsonism and selective involvement of substantia nigra. 61
25577509 2015
15
Postencephalitic parkinsonism and selective involvement of substantia nigra in childhood. 61
24745788 2015
16
The medical treatment of Parkinson disease from James Parkinson to George Cotzias. 61
25491387 2015
17
Postencephalitic parkinsonism: interesting clinico-imaging correlation. 61
24993469 2014
18
Parkinson's disease presenting with oculogyric crisis in the off period. 61
24694499 2014
19
Centenary of Lewy bodies (1912-2012). 61
23456291 2013
20
Etiologies of Parkinsonism in a century-long autopsy-based cohort. 61
22702335 2013
21
The Demise of Poskanzer and Schwab's Influenza Theory on the Pathogenesis of Parkinson's Disease. 61
23853734 2013
22
Association of Parkinson's disease with infections and occupational exposure to possible vectors. 61
22753266 2012
23
Effect of deep brain stimulation on postencephalitic parkinsonism: a case report. 61
22555963 2012
24
The Wilson films--post encephalitic Parkinsonism. 61
22170267 2011
25
A film of patients with movement disorders made in Queen Square, London in the Mid-1920s by Samuel Alexander Kinnier Wilson. 61
21370261 2011
26
Postencephalitic parkinsonism and basal ganglia necrosis due to Epstein-Barr virus infection. 61
21519006 2011
27
The diagnosis of postencephalitic parkinsonism at the neurological unit of Boston City Hospital, 1930-1981. 61
21327402 2011
28
Does the historical literature on encephalitis lethargica support a simple (direct) relationship with postencephalitic Parkinsonism? 61
20629127 2010
29
A historical analysis of the relationship between encephalitis lethargica and postencephalitic parkinsonism: a complex rather than a direct relationship. 61
20629120 2010
30
Rosenow's rabbits and postencephalitic parkinsonism. 61
19822874 2009
31
Absence of alpha-synuclein pathology in postencephalitic parkinsonism. 61
19404653 2009
32
Constantin von Economo's contribution to the understanding of movement disorders. 61
17290463 2007
33
West Nile virus encephalomyelitis with polio-like paralysis & nigral degeneration. 61
17168167 2006
34
Topographic study of Alzheimer's neurofibrillary changes: a personal perspective. 61
16914844 2006
35
Movement disorders associated with encephalitis lethargica: a video compilation. 61
16200538 2006
36
Progressive supranuclear palsy: new disease or variant of postencephalitic parkinsonism? 61
15022178 2004
37
Parkinson's syndrome associated with neurofibrillary degeneration and tau pathologic findings. 61
14502653 2003
38
Dementia with Lewy bodies and the neurobehavioral decline of Mervyn Peake. 61
12810496 2003
39
Unexplained sudden amnesia, postencephalitic Parkinson disease, subacute sclerosing panencephalitis, and Alzheimer disease: does viral synergy produce neurofibrillary tangles? 61
12707087 2003
40
A fatal case of coxsackievirus B4 meningoencephalitis. 61
12533096 2003
41
Friedrich Heinrich Lewy (1885-1950) and his work. 61
12012571 2002
42
von Economo encephalitis. 61
11594935 2001
43
An autopsy case of postencephalitic parkinsonism of von Economo type: some new observations concerning neurofibrillary tangles and astrocytic tangles. 61
10935451 2000
44
FDG- and Dopa-PET in postencephalitic parkinsonism. 61
11145004 2000
45
Parkinsonism, dementia and vertical gaze palsy in a Guamanian with atypical neuroglial degeneration. 61
10651031 2000
46
Neuropsychiatry of Huntington's disease and other basal ganglia disorders. 61
10665265 2000
47
[Habitual mandibular dislocation in two patients with Parkinson's disease]. 61
10586632 1999
48
Adolf Hitler's Parkinson's disease and an attempt to analyse his personality structure. 61
10053222 1999
49
[Postencephalitic parkinsonism]. 61
10434584 1999
50
Accuracy of the clinical diagnosis of postencephalitic parkinsonism: a clinicopathologic study. 61
10210873 1998

Variations for Postencephalitic Parkinson Disease

Expression for Postencephalitic Parkinson Disease

Search GEO for disease gene expression data for Postencephalitic Parkinson Disease.

Pathways for Postencephalitic Parkinson Disease

GO Terms for Postencephalitic Parkinson Disease

Cellular components related to Postencephalitic Parkinson Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.26 TH TARDBP SNCA SLC6A3 PRKN PINK1
2 cell GO:0005623 10.01 TH SNCA PRKN PARK7 MAPT LRRK2
3 perinuclear region of cytoplasm GO:0048471 9.95 SNCA PRKN PINK1 PARK7 GAK
4 membrane raft GO:0045121 9.8 SLC6A3 PARK7 MAPT LRRK2
5 neuronal cell body GO:0043025 9.77 TH SNCA SLC6A3 MAPT LRRK2
6 mitochondrion GO:0005739 9.76 TH SNCA PRKN PINK1 PARK7 MAPT
7 synaptic vesicle GO:0008021 9.74 TH SNCA LRRK2
8 mitochondrial outer membrane GO:0005741 9.71 SNCA PINK1 MAOB LRRK2
9 cell body GO:0044297 9.7 PINK1 PARK7 MAPT
10 mitochondrial intermembrane space GO:0005758 9.69 SNCA PINK1 PARK7
11 presynapse GO:0098793 9.62 SNCA PRKN PARK7 GAK
12 terminal bouton GO:0043195 9.61 TH SNCA LRRK2
13 inclusion body GO:0016234 9.56 SNCA LRRK2
14 growth cone GO:0030426 9.56 SNCA PINK1 MAPT LRRK2
15 Lewy body GO:0097413 9.46 PRKN PINK1
16 neuron projection GO:0043005 9.43 TH SLC6A3 PRKN PARK7 MAPT LRRK2
17 axon GO:0030424 9.17 TH SNCA SLC6A3 PINK1 PARK7 MAPT

Biological processes related to Postencephalitic Parkinson Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.98 TH SNCA SLC6A3 MAOB
2 negative regulation of gene expression GO:0010629 9.91 TARDBP PRKN PINK1 PARK7 MAPT
3 response to lipopolysaccharide GO:0032496 9.9 TH SNCA MAOB
4 autophagy GO:0006914 9.89 PRKN PINK1 PARK7 LRRK2
5 response to oxidative stress GO:0006979 9.88 PRKN PINK1 LRRK2
6 response to ethanol GO:0045471 9.88 TH SLC6A3 MAOB
7 negative regulation of neuron apoptotic process GO:0043524 9.86 SNCA PRKN PINK1 PARK7
8 locomotory behavior GO:0007626 9.85 TH SLC6A3 PRKN
9 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.85 SNCA PINK1 PARK7
10 regulation of protein stability GO:0031647 9.84 TARDBP PRKN LRRK2
11 regulation of autophagy GO:0010506 9.82 PRKN MAPT LRRK2
12 cellular response to oxidative stress GO:0034599 9.8 SNCA PINK1 PARK7 LRRK2
13 adult locomotory behavior GO:0008344 9.78 SNCA PRKN PARK7
14 mitochondrion organization GO:0007005 9.78 PRKN PINK1 PARK7 LRRK2
15 negative regulation of JNK cascade GO:0046329 9.73 PRKN PINK1
16 microglial cell activation GO:0001774 9.73 SNCA MAPT
17 regulation of neuron apoptotic process GO:0043523 9.72 PINK1 PARK7
18 negative regulation of reactive oxygen species metabolic process GO:2000378 9.72 PRKN PINK1
19 regulation of neurotransmitter secretion GO:0046928 9.72 SNCA PRKN
20 regulation of neuron death GO:1901214 9.72 SNCA LRRK2
21 response to corticosterone GO:0051412 9.71 TH MAOB
22 regulation of protein ubiquitination GO:0031396 9.71 PRKN PINK1
23 regulation of mitochondrion organization GO:0010821 9.71 PRKN PINK1
24 regulation of mitochondrial membrane potential GO:0051881 9.71 PRKN PINK1 PARK7
25 cellular response to dopamine GO:1903351 9.7 PRKN LRRK2
26 negative regulation of hydrogen peroxide-induced cell death GO:1903206 9.7 PARK7 LRRK2
27 negative regulation of oxidative stress-induced neuron death GO:1903204 9.7 PINK1 PARK7
28 negative regulation of autophagosome assembly GO:1902902 9.7 PINK1 LRRK2
29 regulation of reactive oxygen species metabolic process GO:2000377 9.7 SNCA PRKN PINK1
30 positive regulation of mitochondrial fission GO:0090141 9.69 PRKN PINK1
31 dopamine metabolic process GO:0042417 9.69 SNCA PRKN
32 neurotransmitter biosynthetic process GO:0042136 9.69 TH SLC6A3
33 negative regulation of macroautophagy GO:0016242 9.68 PINK1 LRRK2
34 supramolecular fiber organization GO:0097435 9.68 SNCA MAPT
35 regulation of dopamine metabolic process GO:0042053 9.67 SLC6A3 PRKN
36 dopamine catabolic process GO:0042420 9.67 SLC6A3 MAOB
37 regulation of mitochondrial fission GO:0090140 9.66 MAPT LRRK2
38 intracellular distribution of mitochondria GO:0048312 9.65 MAPT LRRK2
39 regulation of locomotion GO:0040012 9.65 SNCA LRRK2
40 negative regulation of protein phosphorylation GO:0001933 9.65 TARDBP SNCA PRKN PARK7 LRRK2
41 positive regulation of autophagy of mitochondrion GO:1903599 9.64 PRKN PARK7
42 regulation of protein targeting to mitochondrion GO:1903214 9.64 PRKN PINK1
43 cellular response to toxic substance GO:0097237 9.63 PRKN PINK1
44 protein localization to mitochondrion GO:0070585 9.63 PRKN LRRK2
45 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 9.63 PRKN PARK7 LRRK2
46 positive regulation of histone deacetylase activity GO:1901727 9.62 PINK1 LRRK2
47 regulation of cellular response to oxidative stress GO:1900407 9.62 PRKN PINK1
48 positive regulation of mitophagy in response to mitochondrial depolarization GO:0098779 9.61 PRKN PINK1
49 negative regulation of oxidative stress-induced cell death GO:1903202 9.61 PRKN PINK1 PARK7
50 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903377 9.6 PRKN PARK7

Molecular functions related to Postencephalitic Parkinson Disease according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.85 TARDBP SNCA PRKN PARK7 MAPT LRRK2
2 protein binding GO:0005515 9.8 TH TARDBP SNCA SLC6A3 RCBTB2 PRKN
3 actin binding GO:0003779 9.76 SNCA PRKN MAPT LRRK2
4 double-stranded DNA binding GO:0003690 9.67 TARDBP PARK7 MAPT
5 protein-containing complex binding GO:0044877 9.62 SLC6A3 PRKN PINK1 PARK7
6 chaperone binding GO:0051087 9.61 PRKN MAPT GAK
7 ferrous iron binding GO:0008198 9.52 TH SNCA
8 ubiquitin-specific protease binding GO:1990381 9.51 PRKN PARK7
9 phospholipase binding GO:0043274 9.48 SNCA PRKN
10 dopamine binding GO:0035240 9.4 TH SLC6A3
11 tubulin binding GO:0015631 9.33 PRKN MAPT LRRK2
12 cuprous ion binding GO:1903136 9.26 SNCA PARK7
13 enzyme binding GO:0019899 9.02 TH SNCA PRKN PARK7 MAPT

Sources for Postencephalitic Parkinson Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....