MCID: PST027
MIFTS: 39

Postencephalitic Parkinson Disease

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Postencephalitic Parkinson Disease

MalaCards integrated aliases for Postencephalitic Parkinson Disease:

Name: Postencephalitic Parkinson Disease 12 15
Postencephalitic Parkinsonism 12 59 55
Parkinson Disease, Postencephalitic 44 73

Classifications:

Orphanet: 59  
Rare neurological diseases


Summaries for Postencephalitic Parkinson Disease

MalaCards based summary : Postencephalitic Parkinson Disease, also known as postencephalitic parkinsonism, is related to parkinson disease, late-onset and alzheimer disease. An important gene associated with Postencephalitic Parkinson Disease is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways are Neuroscience and Alpha-synuclein signaling. Affiliated tissues include eye, and related phenotypes are resting tremor and fever

Wikipedia : 76 Post-encephalitic Parkinsonism is a disease believed to be caused by a viral illness that triggers... more...

Related Diseases for Postencephalitic Parkinson Disease

Diseases related to Postencephalitic Parkinson Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 parkinson disease, late-onset 29.8 LRRK2 MAOB MAPT SNCA
2 alzheimer disease 29.0 MAOB MAPT SNCA SYP TARDBP
3 von economo's disease 11.4
4 sleeping sickness 11.1
5 semantic dementia 10.7 MAPT TARDBP
6 hereditary late-onset parkinson disease 10.6 LRRK2 SNCA
7 parkinson disease 10 10.6 LRRK2 SNCA
8 parkinson disease 2, autosomal recessive juvenile 10.6 LRRK2 SNCA
9 spinocerebellar ataxia 11 10.6 MAPT TARDBP
10 leukoencephalopathy, hereditary diffuse, with spheroids 10.6 MAPT SNCA
11 binswanger's disease 10.6 MAPT SYP
12 rem sleep behavior disorder 10.6 LRRK2 SNCA
13 neuronal intranuclear inclusion disease 10.6 MAPT SNCA
14 early-onset parkinson's disease 10.5 LRRK2 SNCA
15 byssinosis 10.5 HLA-A MAPT
16 posterior myocardial infarction 10.4 KANTR MAPT
17 corticobasal degeneration 10.4 LRRK2 MAPT TARDBP
18 nominal aphasia 10.4 MAPT TARDBP
19 childhood oligodendroglioma 10.4 SNCA SYP
20 oculogyric crisis 10.4 KANTR MAOB
21 alexia 10.4 KANTR TARDBP
22 pure autonomic failure 10.3 MAOB SNCA
23 parkinson disease 3, autosomal dominant 10.3 LRRK2 MAPT SNCA
24 dystonia 1, torsion, autosomal dominant 10.3 KANTR MAOB
25 tremor 10.3 LRRK2 MAPT SNCA
26 aphasia 10.3 LRRK2 MAPT SNCA
27 thymic dysplasia 10.3 HLA-A SNCA
28 multiple system atrophy 1 10.3 LRRK2 MAPT SNCA
29 visual agnosia 10.3 KANTR SYP
30 movement disease 10.3 LRRK2 MAPT SNCA
31 niemann-pick disease, type c1 10.3 MAPT SNCA
32 intraocular retinoblastoma 10.3 KANTR SYP
33 pick disease of brain 10.3 MAPT SNCA TARDBP
34 amphetamine abuse 10.2 KANTR MAOB
35 functional colonic disease 10.2 KANTR SYP
36 motor neuron disease 10.2 MAPT SNCA TARDBP
37 cerebellopontine angle tumor 10.2 KANTR SYP
38 hemidystonia 10.2 KANTR SNCA
39 agraphia 10.1 KANTR MAPT TARDBP
40 basal ganglia disease 10.1 MAPT TARDBP
41 speech and communication disorders 10.1 KANTR MAPT TARDBP
42 colonic pseudo-obstruction 10.1 KANTR SYP
43 perry syndrome 10.1 SNCA TARDBP
44 synucleinopathy 10.0 LRRK2 MAOB MAPT SNCA
45 supranuclear palsy, progressive, 1 10.0 LRRK2 MAPT SNCA TARDBP
46 panencephalitis, subacute sclerosing 9.9
47 frontotemporal dementia 9.9 LRRK2 MAPT SNCA TARDBP
48 dementia 9.9 LRRK2 MAPT SNCA TARDBP
49 ideomotor apraxia 9.8 IVL MAPT TARDBP
50 lig4 syndrome 9.7 LRRK2 XRCC6

Graphical network of the top 20 diseases related to Postencephalitic Parkinson Disease:



Diseases related to Postencephalitic Parkinson Disease

Symptoms & Phenotypes for Postencephalitic Parkinson Disease

Human phenotypes related to Postencephalitic Parkinson Disease:

59 32 (show all 41)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 resting tremor 59 32 hallmark (90%) Very frequent (99-80%) HP:0002322
2 fever 59 32 frequent (33%) Frequent (79-30%) HP:0001945
3 bradykinesia 59 32 frequent (33%) Frequent (79-30%) HP:0002067
4 drowsiness 59 32 frequent (33%) Frequent (79-30%) HP:0002329
5 cogwheel rigidity 59 32 frequent (33%) Frequent (79-30%) HP:0002396
6 poor speech 59 32 frequent (33%) Frequent (79-30%) HP:0002465
7 generalized muscle weakness 59 32 frequent (33%) Frequent (79-30%) HP:0003324
8 babinski sign 59 32 frequent (33%) Frequent (79-30%) HP:0003487
9 oculogyric crisis 59 32 frequent (33%) Frequent (79-30%) HP:0010553
10 open mouth 59 32 occasional (7.5%) Occasional (29-5%) HP:0000194
11 slow saccadic eye movements 59 32 occasional (7.5%) Occasional (29-5%) HP:0000514
12 depressivity 59 32 occasional (7.5%) Occasional (29-5%) HP:0000716
13 seizures 59 32 occasional (7.5%) Occasional (29-5%) HP:0001250
14 dysarthria 59 32 occasional (7.5%) Occasional (29-5%) HP:0001260
15 bilateral ptosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001488
16 vomiting 59 32 occasional (7.5%) Occasional (29-5%) HP:0002013
17 dysphagia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002015
18 akinesia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002304
19 headache 59 32 occasional (7.5%) Occasional (29-5%) HP:0002315
20 dysphasia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002357
21 kyphosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002808
22 paresthesia 59 32 occasional (7.5%) Occasional (29-5%) HP:0003401
23 fixed facial expression 59 32 occasional (7.5%) Occasional (29-5%) HP:0005329
24 hyperactive deep tendon reflexes 59 32 occasional (7.5%) Occasional (29-5%) HP:0006801
25 abnormal aggressive, impulsive or violent behavior 59 32 occasional (7.5%) Occasional (29-5%) HP:0006919
26 auditory hallucinations 59 32 occasional (7.5%) Occasional (29-5%) HP:0008765
27 cough 59 32 occasional (7.5%) Occasional (29-5%) HP:0012735
28 upgaze palsy 59 32 occasional (7.5%) Occasional (29-5%) HP:0025331
29 abnormal csf protein level 59 32 occasional (7.5%) Occasional (29-5%) HP:0025456
30 tremor by anatomical site 59 32 occasional (7.5%) Occasional (29-5%) HP:0030188
31 happy demeanor 59 32 occasional (7.5%) Occasional (29-5%) HP:0040082
32 abnormality of the substantia nigra 59 32 occasional (7.5%) Occasional (29-5%) HP:0045007
33 camptocormia 59 32 occasional (7.5%) Occasional (29-5%) HP:0100595
34 csf lymphocytic pleiocytosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0200149
35 involuntary movements 59 Frequent (79-30%)
36 abnormal pyramidal signs 59 Frequent (79-30%)
37 abnormality of eye movement 59 Occasional (29-5%)
38 rigidity 59 Occasional (29-5%)
39 diminished movement 59 Occasional (29-5%)
40 functional respiratory abnormality 59 Occasional (29-5%)
41 abnormality of higher mental function 59 Occasional (29-5%)

Drugs & Therapeutics for Postencephalitic Parkinson Disease

Search Clinical Trials , NIH Clinical Center for Postencephalitic Parkinson Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: parkinson disease, postencephalitic

Genetic Tests for Postencephalitic Parkinson Disease

Anatomical Context for Postencephalitic Parkinson Disease

MalaCards organs/tissues related to Postencephalitic Parkinson Disease:

41
Eye

Publications for Postencephalitic Parkinson Disease

Articles related to Postencephalitic Parkinson Disease:

# Title Authors Year
1
Von Economo's disease and postencephalitic parkinsonism responsive to carbidopa and levodopa. ( 29670352 )
2018
2
Absence of alpha-synuclein pathology in postencephalitic parkinsonism. ( 19404653 )
2009
3
Progressive supranuclear palsy: new disease or variant of postencephalitic parkinsonism? ( 15022178 )
2004
4
Unexplained sudden amnesia, postencephalitic Parkinson disease, subacute sclerosing panencephalitis, and Alzheimer disease: does viral synergy produce neurofibrillary tangles? ( 12707087 )
2003
5
Pathological tau proteins in postencephalitic parkinsonism: comparison with Alzheimer's disease and other neurodegenerative disorders. ( 9307257 )
1997
6
A neuropathologic study of long-term, Economo-type postencephalitic parkinsonism with a prolonged clinical course. ( 8783379 )
1996
7
[An autopsy case of postencephalitic parkinsonism: investigation on neurofibrillary tangles in comparison with those in progressive supranuclear palsy]. ( 2169789 )
1990

Variations for Postencephalitic Parkinson Disease

Expression for Postencephalitic Parkinson Disease

Search GEO for disease gene expression data for Postencephalitic Parkinson Disease.

Pathways for Postencephalitic Parkinson Disease

Pathways related to Postencephalitic Parkinson Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 LRRK2 MAPT SNCA SYP TARDBP
2 10.46 MAOB SNCA

GO Terms for Postencephalitic Parkinson Disease

Cellular components related to Postencephalitic Parkinson Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial outer membrane GO:0005741 9.5 LRRK2 MAOB SNCA
2 growth cone GO:0030426 9.33 LRRK2 MAPT SNCA
3 inclusion body GO:0016234 9.26 LRRK2 SNCA
4 synaptic vesicle GO:0008021 9.13 LRRK2 SNCA SYP
5 terminal bouton GO:0043195 8.8 LRRK2 SNCA SYP

Biological processes related to Postencephalitic Parkinson Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 synapse organization GO:0050808 9.51 MAPT SNCA
2 positive regulation of neuron death GO:1901216 9.49 MAPT SNCA
3 synaptic vesicle endocytosis GO:0048488 9.48 SNCA SYP
4 regulation of long-term neuronal synaptic plasticity GO:0048169 9.46 SNCA SYP
5 regulation of neuronal synaptic plasticity GO:0048168 9.43 SNCA SYP
6 regulation of neuron death GO:1901214 9.4 LRRK2 SNCA
7 microglial cell activation GO:0001774 9.37 MAPT SNCA
8 supramolecular fiber organization GO:0097435 9.32 MAPT SNCA
9 intracellular distribution of mitochondria GO:0048312 9.26 LRRK2 MAPT
10 regulation of mitochondrial fission GO:0090140 9.16 LRRK2 MAPT
11 regulation of locomotion GO:0040012 8.96 LRRK2 SNCA
12 negative regulation of protein phosphorylation GO:0001933 8.8 LRRK2 SNCA TARDBP

Molecular functions related to Postencephalitic Parkinson Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 LRRK2 MAPT SNCA SYP TARDBP
2 microtubule binding GO:0008017 9.33 LRRK2 MAPT SNCA
3 double-stranded DNA binding GO:0003690 8.8 MAPT TARDBP XRCC6

Sources for Postencephalitic Parkinson Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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