MCID: PST027
MIFTS: 44

Postencephalitic Parkinson Disease

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Postencephalitic Parkinson Disease

MalaCards integrated aliases for Postencephalitic Parkinson Disease:

Name: Postencephalitic Parkinson Disease 12 15
Postencephalitic Parkinsonism 12 59 55
Parkinson Disease, Postencephalitic 44 73

Classifications:

Orphanet: 59  
Rare neurological diseases


Summaries for Postencephalitic Parkinson Disease

MalaCards based summary : Postencephalitic Parkinson Disease, also known as postencephalitic parkinsonism, is related to supranuclear palsy, progressive, 1 and dementia. An important gene associated with Postencephalitic Parkinson Disease is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways are Neuroscience and Alpha-synuclein signaling. Affiliated tissues include eye, brain and cortex, and related phenotypes are depressivity and seizures

Wikipedia : 76 Post-encephalitic Parkinsonism is a disease believed to be caused by a viral illness that triggers... more...

Related Diseases for Postencephalitic Parkinson Disease

Diseases related to Postencephalitic Parkinson Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 supranuclear palsy, progressive, 1 30.6 LRRK2 MAPT SNCA TARDBP
2 dementia 30.4 LRRK2 MAPT SNCA TARDBP
3 tremor 30.2 LRRK2 MAPT SNCA
4 movement disease 30.2 LRRK2 MAPT SNCA
5 early-onset parkinson's disease 30.1 LRRK2 SNCA
6 parkinson disease, late-onset 30.0 LRRK2 MAOB MAPT SNCA
7 alzheimer disease 29.8 MAOB MAPT SNCA SYP TARDBP
8 von economo's disease 11.6
9 sleeping sickness 11.3
10 influenza 10.3
11 encephalitis 10.3
12 nominal aphasia 10.2 MAPT TARDBP
13 semantic dementia 10.2 MAPT TARDBP
14 aphasia 10.2 MAPT SNCA
15 hereditary late-onset parkinson disease 10.2 LRRK2 SNCA
16 primary lateral sclerosis, adult, 1 10.2 MAPT SNCA
17 parkinson disease 10 10.2 LRRK2 SNCA
18 neuronal intranuclear inclusion disease 10.2 MAPT SNCA
19 rem sleep behavior disorder 10.2 LRRK2 SNCA
20 byssinosis 10.2 HLA-A MAPT
21 spinocerebellar ataxia 11 10.2 MAPT TARDBP
22 binswanger's disease 10.2 MAPT SYP
23 skin sarcoma 10.1 MAPT SYP
24 posterior myocardial infarction 10.1 KANTR MAPT
25 thymic dysplasia 10.1 HLA-A SNCA
26 corticobasal degeneration 10.1 LRRK2 MAPT TARDBP
27 childhood oligodendroglioma 10.1 SNCA SYP
28 alexia 10.1 KANTR TARDBP
29 oculogyric crisis 10.1 KANTR MAOB
30 parkinson disease 3, autosomal dominant 10.1 LRRK2 MAPT SNCA
31 multiple system atrophy 1 10.1 LRRK2 MAPT SNCA
32 pure autonomic failure 10.1 MAOB SNCA
33 pick disease of brain 10.1 MAPT SNCA TARDBP
34 dystonia 1, torsion, autosomal dominant 10.1 KANTR MAOB
35 disease of mental health 10.1 MAPT SNCA TARDBP
36 anterior cranial fossa meningioma 10.1 KANTR SYP
37 visual agnosia 10.1 KANTR SYP
38 motor neuron disease 10.1 MAPT SNCA TARDBP
39 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 10.1 MAPT TARDBP
40 parkinson disease 2, autosomal recessive juvenile 10.1 LRRK2 SNCA
41 abducens nerve disease 10.1 KANTR SYP
42 functional colonic disease 10.1 KANTR SYP
43 intraocular retinoblastoma 10.1 KANTR SYP
44 amphetamine abuse 10.1 KANTR MAOB
45 hemidystonia 10.0 KANTR SNCA
46 agraphia 10.0 KANTR MAPT TARDBP
47 speech and communication disorders 10.0 KANTR MAPT TARDBP
48 panencephalitis, subacute sclerosing 10.0
49 cerebellopontine angle tumor 10.0 KANTR SYP
50 colonic pseudo-obstruction 10.0 KANTR SYP

Graphical network of the top 20 diseases related to Postencephalitic Parkinson Disease:



Diseases related to Postencephalitic Parkinson Disease

Symptoms & Phenotypes for Postencephalitic Parkinson Disease

Human phenotypes related to Postencephalitic Parkinson Disease:

59 32 (show all 41)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 depressivity 59 32 occasional (7.5%) Occasional (29-5%) HP:0000716
2 seizures 59 32 occasional (7.5%) Occasional (29-5%) HP:0001250
3 dysarthria 59 32 occasional (7.5%) Occasional (29-5%) HP:0001260
4 dysphagia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002015
5 dysphasia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002357
6 kyphosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002808
7 fever 59 32 frequent (33%) Frequent (79-30%) HP:0001945
8 vomiting 59 32 occasional (7.5%) Occasional (29-5%) HP:0002013
9 generalized muscle weakness 59 32 frequent (33%) Frequent (79-30%) HP:0003324
10 babinski sign 59 32 frequent (33%) Frequent (79-30%) HP:0003487
11 paresthesia 59 32 occasional (7.5%) Occasional (29-5%) HP:0003401
12 open mouth 59 32 occasional (7.5%) Occasional (29-5%) HP:0000194
13 cough 59 32 occasional (7.5%) Occasional (29-5%) HP:0012735
14 headache 59 32 occasional (7.5%) Occasional (29-5%) HP:0002315
15 bradykinesia 59 32 frequent (33%) Frequent (79-30%) HP:0002067
16 slow saccadic eye movements 59 32 occasional (7.5%) Occasional (29-5%) HP:0000514
17 drowsiness 59 32 frequent (33%) Frequent (79-30%) HP:0002329
18 oculogyric crisis 59 32 frequent (33%) Frequent (79-30%) HP:0010553
19 hyperactive deep tendon reflexes 59 32 occasional (7.5%) Occasional (29-5%) HP:0006801
20 bilateral ptosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001488
21 poor speech 59 32 frequent (33%) Frequent (79-30%) HP:0002465
22 abnormal csf protein level 59 32 occasional (7.5%) Occasional (29-5%) HP:0025456
23 akinesia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002304
24 cogwheel rigidity 59 32 frequent (33%) Frequent (79-30%) HP:0002396
25 resting tremor 59 32 hallmark (90%) Very frequent (99-80%) HP:0002322
26 happy demeanor 59 32 occasional (7.5%) Occasional (29-5%) HP:0040082
27 camptocormia 59 32 occasional (7.5%) Occasional (29-5%) HP:0100595
28 abnormality of the substantia nigra 59 32 occasional (7.5%) Occasional (29-5%) HP:0045007
29 auditory hallucinations 59 32 occasional (7.5%) Occasional (29-5%) HP:0008765
30 fixed facial expression 59 32 occasional (7.5%) Occasional (29-5%) HP:0005329
31 abnormal aggressive, impulsive or violent behavior 59 32 occasional (7.5%) Occasional (29-5%) HP:0006919
32 upgaze palsy 59 32 occasional (7.5%) Occasional (29-5%) HP:0025331
33 tremor by anatomical site 59 32 occasional (7.5%) Occasional (29-5%) HP:0030188
34 csf lymphocytic pleiocytosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0200149
35 abnormality of eye movement 59 Occasional (29-5%)
36 abnormal pyramidal signs 59 Frequent (79-30%)
37 rigidity 59 Occasional (29-5%)
38 functional respiratory abnormality 59 Occasional (29-5%)
39 involuntary movements 59 Frequent (79-30%)
40 abnormality of higher mental function 59 Occasional (29-5%)
41 diminished movement 59 Occasional (29-5%)

Drugs & Therapeutics for Postencephalitic Parkinson Disease

Search Clinical Trials , NIH Clinical Center for Postencephalitic Parkinson Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: parkinson disease, postencephalitic

Genetic Tests for Postencephalitic Parkinson Disease

Anatomical Context for Postencephalitic Parkinson Disease

MalaCards organs/tissues related to Postencephalitic Parkinson Disease:

41
Eye, Brain, Cortex, Skin, Colon

Publications for Postencephalitic Parkinson Disease

Articles related to Postencephalitic Parkinson Disease:

(show top 50) (show all 60)
# Title Authors Year
1
Von Economo's disease and postencephalitic parkinsonism responsive to carbidopa and levodopa. ( 29670352 )
2018
2
Powassan virus postencephalitic parkinsonism. ( 29431163 )
2017
3
Enteroviral Postencephalitic Parkinsonism With Evidence of Impaired Presynaptic Dopaminergic Function. ( 27367905 )
2016
4
Poster 319 Response of Postencephalitic Parkinsonism to Various Dopaminergic Agonists: A Case Report. ( 27673072 )
2016
5
Postencephalitic parkinsonism and selective involvement of substantia nigra in childhood. ( 24745788 )
2015
6
Postencephalitic parkinsonism and selective involvement of substantia nigra. ( 25577509 )
2015
7
Postencephalitic parkinsonism responsive to a dopamine agonist: A case report. ( 25899543 )
2015
8
Postencephalitic parkinsonism: interesting clinico-imaging correlation. ( 24993469 )
2014
9
Effect of deep brain stimulation on postencephalitic parkinsonism: a case report. ( 22555963 )
2012
10
The diagnosis of postencephalitic parkinsonism at the neurological unit of Boston City Hospital, 1930-1981. ( 21327402 )
2011
11
Postencephalitic parkinsonism and basal ganglia necrosis due to Epstein-Barr virus infection. ( 21519006 )
2011
12
A historical analysis of the relationship between encephalitis lethargica and postencephalitic parkinsonism: a complex rather than a direct relationship. ( 20629120 )
2010
13
Does the historical literature on encephalitis lethargica support a simple (direct) relationship with postencephalitic Parkinsonism? ( 20629127 )
2010
14
Absence of alpha-synuclein pathology in postencephalitic parkinsonism. ( 19404653 )
2009
15
Rosenow's rabbits and postencephalitic parkinsonism. ( 19822874 )
2009
16
Progressive supranuclear palsy: new disease or variant of postencephalitic parkinsonism? ( 15022178 )
2004
17
Unexplained sudden amnesia, postencephalitic Parkinson disease, subacute sclerosing panencephalitis, and Alzheimer disease: does viral synergy produce neurofibrillary tangles? ( 12707087 )
2003
18
An autopsy case of postencephalitic parkinsonism of von Economo type: some new observations concerning neurofibrillary tangles and astrocytic tangles. ( 10935451 )
2000
19
FDG- and Dopa-PET in postencephalitic parkinsonism. ( 11145004 )
2000
20
Early cinematographic cases of postencephalitic parkinsonism and other movement disorders. ( 9452345 )
1998
21
Postencephalitic parkinsonism--a review. ( 9826109 )
1998
22
Accuracy of the clinical diagnosis of postencephalitic parkinsonism: a clinicopathologic study. ( 10210873 )
1998
23
Pathological tau proteins in postencephalitic parkinsonism: comparison with Alzheimer's disease and other neurodegenerative disorders. ( 9307257 )
1997
24
Supranuclear gaze palsy and eyelid apraxia in postencephalitic parkinsonism. ( 9451717 )
1997
25
A neuropathologic study of long-term, Economo-type postencephalitic parkinsonism with a prolonged clinical course. ( 8783379 )
1996
26
Possible clinical overlap between postencephalitic parkinsonism and progressive supranuclear palsy. ( 8778274 )
1996
27
MRI of transient postencephalitic parkinsonism. ( 8282871 )
1994
28
Anti-tau-positive glial fibrillary tangles in the brain of postencephalitic parkinsonism of Economo type. ( 8121623 )
1993
29
Pathological overlap in cases of parkinsonism associated with neurofibrillary tangles. A study of recent cases of postencephalitic parkinsonism and comparison with progressive supranuclear palsy and Guamanian parkinsonism-dementia complex. ( 8453463 )
1993
30
Cranial dystonia (Meige syndrome) in postencephalitic parkinsonism. ( 1557074 )
1992
31
Distribution of neurofibrillary tangles and senile plaques in the cerebral cortex in postencephalitic parkinsonism. ( 1407674 )
1992
32
[An autopsy case of postencephalitic parkinsonism: investigation on neurofibrillary tangles in comparison with those in progressive supranuclear palsy]. ( 2169789 )
1990
33
Sleep apnea in idiopathic and postencephalitic parkinsonism. ( 3825701 )
1987
34
Immunocytochemical comparison of neurofibrillary tangles in senile dementia of Alzheimer type, progressive supranuclear palsy, and postencephalitic parkinsonism. ( 6187274 )
1983
35
Old photographs: postencephalitic Parkinsonism in two small boys. ( 6644320 )
1983
36
Histocompatibility antigens and postencephalitic Parkinsonism. ( 6886712 )
1983
37
Frequency of Alzheimer's neurofibrillary tangle in the brains of progressive supranuclear palsy, postencephalitic parkinsonism, Alzheimer's disease, senile dementia and non-demented elderly person. ( 7286861 )
1981
38
Distribution and ultrastructure of Alzheimer's neurofibrillary tangles in postencephalitic Parkinsonism of Economo type. ( 7348007 )
1981
39
Oligoclonal banding in the cerebrospinal fluid of patients with postencephalitic Parkinsonism. ( 501378 )
1979
40
Influenza virus antigen in postencephalitic parkinsonism brain. Detection by immunofluorescence. ( 4370102 )
1974
41
Influenza A virus as a possible cause of postencephalitic Parkinsonism. ( 4594185 )
1973
42
Response of patients with postencephalitic Parkinsonism to levodopa. ( 5049808 )
1972
43
Benign early onset of Parkinson's disease: a syndrome distinct from classic postencephalitic parkinsonism. ( 5102868 )
1971
44
Benign early-onset Parkinson's disease: a syndrome distinct from classic postencephalitic parkinsonism. ( 5535037 )
1970
45
Levodopa in postencephalitic parkinsonism. ( 4098944 )
1970
46
Side-effects of L-dopa in postencephalitic parkinsonism. ( 4195790 )
1970
47
L-dopa for postencephalitic Parkinsonism. ( 5481239 )
1970
48
Dissociation of antitremorine activity and clinical antiparkinsonian effect. A clinical trial of AGN 511 in postencephalitic parkinsonism. ( 5537091 )
1970
49
L-dopa in postencephalitic parkinsonism. ( 4180215 )
1969
50
Para-encephalitic parkinsonism. Report of an acute case due to coxsackie virus type B 2 and re-examination of the etiologic concepts of postencephalitic parkinsonism. ( 5800856 )
1969

Variations for Postencephalitic Parkinson Disease

Expression for Postencephalitic Parkinson Disease

Search GEO for disease gene expression data for Postencephalitic Parkinson Disease.

Pathways for Postencephalitic Parkinson Disease

Pathways related to Postencephalitic Parkinson Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 LRRK2 MAPT SNCA SYP TARDBP
2 10.46 MAOB SNCA

GO Terms for Postencephalitic Parkinson Disease

Cellular components related to Postencephalitic Parkinson Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial outer membrane GO:0005741 9.54 LRRK2 MAOB SNCA
2 growth cone GO:0030426 9.43 LRRK2 MAPT SNCA
3 synaptic vesicle GO:0008021 9.33 LRRK2 SNCA SYP
4 inclusion body GO:0016234 9.32 LRRK2 SNCA
5 synaptic vesicle membrane GO:0030672 9.13 LRRK2 SNCA SYP
6 terminal bouton GO:0043195 8.8 LRRK2 SNCA SYP

Biological processes related to Postencephalitic Parkinson Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 regulation of synaptic vesicle exocytosis GO:2000300 9.54 LRRK2 SYP
2 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.52 LGALS7 LGALS7B
3 synapse organization GO:0050808 9.51 MAPT SNCA
4 positive regulation of neuron death GO:1901216 9.49 MAPT SNCA
5 synaptic vesicle endocytosis GO:0048488 9.48 SNCA SYP
6 regulation of long-term neuronal synaptic plasticity GO:0048169 9.46 SNCA SYP
7 regulation of neuron death GO:1901214 9.43 LRRK2 SNCA
8 regulation of neuronal synaptic plasticity GO:0048168 9.4 SNCA SYP
9 microglial cell activation GO:0001774 9.37 MAPT SNCA
10 supramolecular fiber organization GO:0097435 9.32 MAPT SNCA
11 intracellular distribution of mitochondria GO:0048312 9.26 LRRK2 MAPT
12 regulation of locomotion GO:0040012 9.16 LRRK2 SNCA
13 regulation of mitochondrial fission GO:0090140 8.96 LRRK2 MAPT
14 negative regulation of protein phosphorylation GO:0001933 8.8 LRRK2 SNCA TARDBP

Molecular functions related to Postencephalitic Parkinson Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 LRRK2 MAPT SNCA SYP TARDBP
2 microtubule binding GO:0008017 9.33 LRRK2 MAPT SNCA
3 double-stranded DNA binding GO:0003690 8.8 MAPT TARDBP XRCC6

Sources for Postencephalitic Parkinson Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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