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MCID: PST027
MIFTS: 43

Postencephalitic Parkinson Disease

Categories: Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Postencephalitic Parkinson Disease

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MalaCards integrated aliases for Postencephalitic Parkinson Disease:

Name: Postencephalitic Parkinson Disease 12 15 17
Postencephalitic Parkinsonism 12 60 56
Parkinson Disease, Postencephalitic 45 74

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 34 35
Orphanet: 60  
Rare neurological diseases


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Summaries for Postencephalitic Parkinson Disease

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MalaCards based summary : Postencephalitic Parkinson Disease, also known as postencephalitic parkinsonism, is related to supranuclear palsy, progressive, 1 and dementia. An important gene associated with Postencephalitic Parkinson Disease is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways are Neuroscience and Alpha-synuclein signaling. Affiliated tissues include eye, brain and colon, and related phenotypes are resting tremor and fever

Wikipedia : 77 Post-encephalitic Parkinsonism is a disease believed to be caused by a viral illness that triggers... more...

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Related Diseases for Postencephalitic Parkinson Disease

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Diseases related to Postencephalitic Parkinson Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 supranuclear palsy, progressive, 1 30.9 LRRK2 MAPT SNCA
2 dementia 30.7 LRRK2 MAPT SNCA
3 tremor 30.3 LRRK2 MAPT SNCA
4 movement disease 30.3 LRRK2 MAPT SNCA
5 early-onset parkinson's disease 30.3 LRRK2 RAB39B SNCA
6 parkinson disease, late-onset 29.8 LRRK2 MAOB MAPT RAB39B SNCA
7 alzheimer disease 29.7 MAOB MAPT SNCA SYP
8 von economo's disease 10.4
9 influenza 10.4
10 encephalitis 10.4
11 primary lateral sclerosis, adult, 1 10.3 MAPT SNCA
12 neuronal intranuclear inclusion disease 10.3 MAPT SNCA
13 byssinosis 10.3 HLA-A MAPT
14 hereditary late-onset parkinson disease 10.3 LRRK2 SNCA
15 parkinson disease 10 10.3 LRRK2 SNCA
16 rem sleep behavior disorder 10.3 LRRK2 SNCA
17 binswanger's disease 10.3 MAPT SYP
18 corticobasal degeneration 10.2 LRRK2 MAPT
19 skin sarcoma 10.2 MAPT SYP
20 thymic dysplasia 10.2 HLA-A SNCA
21 posterior myocardial infarction 10.2 KANTR MAPT
22 childhood oligodendroglioma 10.2 SNCA SYP
23 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 10.2 MAPT RAB39B
24 oculogyric crisis 10.2 KANTR MAOB
25 pure autonomic failure 10.2 MAOB SNCA
26 x-linked non-specific intellectual disability 10.2 RAB39B SYP
27 agraphia 10.2 KANTR MAPT
28 dystonia 1, torsion, autosomal dominant 10.2 KANTR MAOB
29 parkinson disease 2, autosomal recessive juvenile 10.2 LRRK2 SNCA
30 parkinson disease 3, autosomal dominant 10.1 LRRK2 MAPT SNCA
31 multiple system atrophy 1 10.1 LRRK2 MAPT SNCA
32 anterior cranial fossa meningioma 10.1 KANTR SYP
33 visual agnosia 10.1 KANTR SYP
34 amphetamine abuse 10.1 KANTR MAOB
35 frontotemporal dementia 10.1 LRRK2 MAPT SNCA
36 abducens nerve disease 10.1 KANTR SYP
37 functional colonic disease 10.1 KANTR SYP
38 intraocular retinoblastoma 10.1 KANTR SYP
39 hemidystonia 10.1 KANTR SNCA
40 panencephalitis, subacute sclerosing 10.1
41 amnestic disorder 10.1
42 cerebellopontine angle tumor 10.1 KANTR SYP
43 lymphatic malformation 5 10.1
44 sleep apnea 10.1
45 apraxia 10.1
46 dystonia 10.1
47 supranuclear ocular palsy 10.1
48 colonic pseudo-obstruction 10.1 KANTR SYP
49 syndromic x-linked intellectual disability 10.1 RAB39B SYP
50 lig4 syndrome 10.0 LRRK2 XRCC6

Graphical network of the top 20 diseases related to Postencephalitic Parkinson Disease:



Diseases related to Postencephalitic Parkinson Disease
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Symptoms & Phenotypes for Postencephalitic Parkinson Disease

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Human phenotypes related to Postencephalitic Parkinson Disease:

60 33 (show all 41)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 resting tremor 60 33 hallmark (90%) Very frequent (99-80%) HP:0002322
2 fever 60 33 frequent (33%) Frequent (79-30%) HP:0001945
3 generalized muscle weakness 60 33 frequent (33%) Frequent (79-30%) HP:0003324
4 babinski sign 60 33 frequent (33%) Frequent (79-30%) HP:0003487
5 bradykinesia 60 33 frequent (33%) Frequent (79-30%) HP:0002067
6 drowsiness 60 33 frequent (33%) Frequent (79-30%) HP:0002329
7 oculogyric crisis 60 33 frequent (33%) Frequent (79-30%) HP:0010553
8 poor speech 60 33 frequent (33%) Frequent (79-30%) HP:0002465
9 cogwheel rigidity 60 33 frequent (33%) Frequent (79-30%) HP:0002396
10 depressivity 60 33 occasional (7.5%) Occasional (29-5%) HP:0000716
11 seizures 60 33 occasional (7.5%) Occasional (29-5%) HP:0001250
12 dysarthria 60 33 occasional (7.5%) Occasional (29-5%) HP:0001260
13 dysphagia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002015
14 dysphasia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002357
15 kyphosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0002808
16 vomiting 60 33 occasional (7.5%) Occasional (29-5%) HP:0002013
17 paresthesia 60 33 occasional (7.5%) Occasional (29-5%) HP:0003401
18 headache 60 33 occasional (7.5%) Occasional (29-5%) HP:0002315
19 open mouth 60 33 occasional (7.5%) Occasional (29-5%) HP:0000194
20 cough 60 33 occasional (7.5%) Occasional (29-5%) HP:0012735
21 hyperactive deep tendon reflexes 60 33 occasional (7.5%) Occasional (29-5%) HP:0006801
22 slow saccadic eye movements 60 33 occasional (7.5%) Occasional (29-5%) HP:0000514
23 bilateral ptosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0001488
24 abnormal csf protein level 60 33 occasional (7.5%) Occasional (29-5%) HP:0025456
25 akinesia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002304
26 abnormal aggressive, impulsive or violent behavior 60 33 occasional (7.5%) Occasional (29-5%) HP:0006919
27 happy demeanor 60 33 occasional (7.5%) Occasional (29-5%) HP:0040082
28 camptocormia 60 33 occasional (7.5%) Occasional (29-5%) HP:0100595
29 fixed facial expression 60 33 occasional (7.5%) Occasional (29-5%) HP:0005329
30 abnormality of the substantia nigra 60 33 occasional (7.5%) Occasional (29-5%) HP:0045007
31 auditory hallucinations 60 33 occasional (7.5%) Occasional (29-5%) HP:0008765
32 upgaze palsy 60 33 occasional (7.5%) Occasional (29-5%) HP:0025331
33 tremor by anatomical site 60 33 occasional (7.5%) Occasional (29-5%) HP:0030188
34 csf lymphocytic pleiocytosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0200149
35 abnormality of eye movement 60 Occasional (29-5%)
36 abnormal pyramidal sign 60 Frequent (79-30%)
37 rigidity 60 Occasional (29-5%)
38 functional respiratory abnormality 60 Occasional (29-5%)
39 involuntary movements 60 Frequent (79-30%)
40 abnormality of higher mental function 60 Occasional (29-5%)
41 diminished movement 60 Occasional (29-5%)
Sources

Drugs & Therapeutics for Postencephalitic Parkinson Disease

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Search Clinical Trials , NIH Clinical Center for Postencephalitic Parkinson Disease

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: parkinson disease, postencephalitic

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Genetic Tests for Postencephalitic Parkinson Disease

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Anatomical Context for Postencephalitic Parkinson Disease

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MalaCards organs/tissues related to Postencephalitic Parkinson Disease:

42
Eye, Brain, Colon, Cortex, Skin
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Publications for Postencephalitic Parkinson Disease

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Articles related to Postencephalitic Parkinson Disease:

(show top 50) (show all 59)
# Title Authors Year
1
Von Economo's disease and postencephalitic parkinsonism responsive to carbidopa and levodopa. ( 29670352 )
2018
2
Powassan virus postencephalitic parkinsonism. ( 29431163 )
2017
3
Enteroviral Postencephalitic Parkinsonism With Evidence of Impaired Presynaptic Dopaminergic Function. ( 27367905 )
2016
4
Poster 319 Response of Postencephalitic Parkinsonism to Various Dopaminergic Agonists: A Case Report. ( 27673072 )
2016
5
Postencephalitic parkinsonism and selective involvement of substantia nigra in childhood. ( 24745788 )
2015
6
Postencephalitic parkinsonism and selective involvement of substantia nigra. ( 25577509 )
2015
7
Postencephalitic parkinsonism responsive to a dopamine agonist: A case report. ( 25899543 )
2015
8
Postencephalitic parkinsonism: interesting clinico-imaging correlation. ( 24993469 )
2014
9
Effect of deep brain stimulation on postencephalitic parkinsonism: a case report. ( 22555963 )
2012
10
The diagnosis of postencephalitic parkinsonism at the neurological unit of Boston City Hospital, 1930-1981. ( 21327402 )
2011
11
Postencephalitic parkinsonism and basal ganglia necrosis due to Epstein-Barr virus infection. ( 21519006 )
2011
12
A historical analysis of the relationship between encephalitis lethargica and postencephalitic parkinsonism: a complex rather than a direct relationship. ( 20629120 )
2010
13
Does the historical literature on encephalitis lethargica support a simple (direct) relationship with postencephalitic Parkinsonism? ( 20629127 )
2010
14
Absence of alpha-synuclein pathology in postencephalitic parkinsonism. ( 19404653 )
2009
15
Rosenow's rabbits and postencephalitic parkinsonism. ( 19822874 )
2009
16
Progressive supranuclear palsy: new disease or variant of postencephalitic parkinsonism? ( 15022178 )
2004
17
Unexplained sudden amnesia, postencephalitic Parkinson disease, subacute sclerosing panencephalitis, and Alzheimer disease: does viral synergy produce neurofibrillary tangles? ( 12707087 )
2003
18
An autopsy case of postencephalitic parkinsonism of von Economo type: some new observations concerning neurofibrillary tangles and astrocytic tangles. ( 10935451 )
2000
19
FDG- and Dopa-PET in postencephalitic parkinsonism. ( 11145004 )
2000
20
Early cinematographic cases of postencephalitic parkinsonism and other movement disorders. ( 9452345 )
1998
21
Postencephalitic parkinsonism--a review. ( 9826109 )
1998
22
Accuracy of the clinical diagnosis of postencephalitic parkinsonism: a clinicopathologic study. ( 10210873 )
1998
23
Supranuclear gaze palsy and eyelid apraxia in postencephalitic parkinsonism. ( 9451717 )
1997
24
Pathological tau proteins in postencephalitic parkinsonism: comparison with Alzheimer's disease and other neurodegenerative disorders. ( 9307257 )
1997
25
Possible clinical overlap between postencephalitic parkinsonism and progressive supranuclear palsy. ( 8778274 )
1996
26
A neuropathologic study of long-term, Economo-type postencephalitic parkinsonism with a prolonged clinical course. ( 8783379 )
1996
27
MRI of transient postencephalitic parkinsonism. ( 8282871 )
1994
28
Pathological overlap in cases of parkinsonism associated with neurofibrillary tangles. A study of recent cases of postencephalitic parkinsonism and comparison with progressive supranuclear palsy and Guamanian parkinsonism-dementia complex. ( 8453463 )
1993
29
Anti-tau-positive glial fibrillary tangles in the brain of postencephalitic parkinsonism of Economo type. ( 8121623 )
1993
30
Cranial dystonia (Meige syndrome) in postencephalitic parkinsonism. ( 1557074 )
1992
31
Distribution of neurofibrillary tangles and senile plaques in the cerebral cortex in postencephalitic parkinsonism. ( 1407674 )
1992
32
Sleep apnea in idiopathic and postencephalitic parkinsonism. ( 3825701 )
1987
33
Immunocytochemical comparison of neurofibrillary tangles in senile dementia of Alzheimer type, progressive supranuclear palsy, and postencephalitic parkinsonism. ( 6187274 )
1983
34
Old photographs: postencephalitic Parkinsonism in two small boys. ( 6644320 )
1983
35
Histocompatibility antigens and postencephalitic Parkinsonism. ( 6886712 )
1983
36
Frequency of Alzheimer's neurofibrillary tangle in the brains of progressive supranuclear palsy, postencephalitic parkinsonism, Alzheimer's disease, senile dementia and non-demented elderly person. ( 7286861 )
1981
37
Distribution and ultrastructure of Alzheimer's neurofibrillary tangles in postencephalitic Parkinsonism of Economo type. ( 7348007 )
1981
38
Oligoclonal banding in the cerebrospinal fluid of patients with postencephalitic Parkinsonism. ( 501378 )
1979
39
Influenza virus antigen in postencephalitic parkinsonism brain. Detection by immunofluorescence. ( 4370102 )
1974
40
Influenza A virus as a possible cause of postencephalitic Parkinsonism. ( 4594185 )
1973
41
Response of patients with postencephalitic Parkinsonism to levodopa. ( 5049808 )
1972
42
Benign early onset of Parkinson's disease: a syndrome distinct from classic postencephalitic parkinsonism. ( 5102868 )
1971
43
Benign early-onset Parkinson's disease: a syndrome distinct from classic postencephalitic parkinsonism. ( 5535037 )
1970
44
Levodopa in postencephalitic parkinsonism. ( 4098944 )
1970
45
Side-effects of L-dopa in postencephalitic parkinsonism. ( 4195790 )
1970
46
L-dopa for postencephalitic Parkinsonism. ( 5481239 )
1970
47
Dissociation of antitremorine activity and clinical antiparkinsonian effect. A clinical trial of AGN 511 in postencephalitic parkinsonism. ( 5537091 )
1970
48
L-dopa in postencephalitic parkinsonism. ( 4180215 )
1969
49
Para-encephalitic parkinsonism. Report of an acute case due to coxsackie virus type B 2 and re-examination of the etiologic concepts of postencephalitic parkinsonism. ( 5800856 )
1969
50
Distribution of the brain stem lesions in postencephalitic Parkinsonism. ( 5919815 )
1966
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Variations for Postencephalitic Parkinson Disease

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Expression for Postencephalitic Parkinson Disease

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Search GEO for disease gene expression data for Postencephalitic Parkinson Disease.
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Pathways for Postencephalitic Parkinson Disease

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Pathways related to Postencephalitic Parkinson Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
11.46 LRRK2 MAPT SNCA SYP
2
Alpha-synuclein signaling 1
10.46 MAOB SNCA
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GO Terms for Postencephalitic Parkinson Disease

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Cellular components related to Postencephalitic Parkinson Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial outer membrane GO:0005741 9.58 LRRK2 MAOB SNCA
2 neuron projection GO:0043005 9.56 LRRK2 MAPT RAB39B SYP
3 growth cone GO:0030426 9.5 LRRK2 MAPT SNCA
4 inclusion body GO:0016234 9.37 LRRK2 SNCA
5 synaptic vesicle GO:0008021 9.33 LRRK2 SNCA SYP
6 synaptic vesicle membrane GO:0030672 9.13 LRRK2 SNCA SYP
7 terminal bouton GO:0043195 8.8 LRRK2 SNCA SYP

Biological processes related to Postencephalitic Parkinson Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 regulation of synaptic vesicle exocytosis GO:2000300 9.54 LRRK2 SYP
2 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.52 LGALS7 LGALS7B
3 positive regulation of neuron death GO:1901216 9.51 MAPT SNCA
4 synaptic vesicle endocytosis GO:0048488 9.49 SNCA SYP
5 regulation of long-term neuronal synaptic plasticity GO:0048169 9.48 SNCA SYP
6 regulation of neuron death GO:1901214 9.46 LRRK2 SNCA
7 regulation of neuronal synaptic plasticity GO:0048168 9.43 SNCA SYP
8 microglial cell activation GO:0001774 9.4 MAPT SNCA
9 supramolecular fiber organization GO:0097435 9.37 MAPT SNCA
10 intracellular distribution of mitochondria GO:0048312 9.32 LRRK2 MAPT
11 regulation of locomotion GO:0040012 9.26 LRRK2 SNCA
12 regulation of mitochondrial fission GO:0090140 9.16 LRRK2 MAPT
13 regulation of autophagy GO:0010506 9.13 LRRK2 MAPT RAB39B
14 synapse organization GO:0050808 8.8 MAPT RAB39B SNCA

Molecular functions related to Postencephalitic Parkinson Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule binding GO:0008017 8.8 LRRK2 MAPT SNCA
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Sources for Postencephalitic Parkinson Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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