PCA
MCID: PST086
MIFTS: 39

Posterior Cortical Atrophy (PCA)

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Posterior Cortical Atrophy

MalaCards integrated aliases for Posterior Cortical Atrophy:

Name: Posterior Cortical Atrophy 60
Biparietal Alzheimer Disease 60
Benson Syndrome 60
Pca 60

Characteristics:

Orphanet epidemiological data:

60
posterior cortical atrophy
Age of onset: Adult; Age of death: adult;

Classifications:

Orphanet: 60  
Rare neurological diseases


Summaries for Posterior Cortical Atrophy

MalaCards based summary : Posterior Cortical Atrophy, also known as biparietal alzheimer disease, is related to simultanagnosia and aphasia. An important gene associated with Posterior Cortical Atrophy is APOE (Apolipoprotein E), and among its related pathways/superpathways are Reelin Pathway (Cajal-Retzius cells) and G-protein signaling_Regulation of RAC1 activity. Affiliated tissues include cortex, brain and eye, and related phenotypes are ataxia and anxiety

Wikipedia : 77 Posterior cortical atrophy (PCA), also called Benson''s syndrome, is a form of dementia which is usually... more...

Related Diseases for Posterior Cortical Atrophy

Diseases related to Posterior Cortical Atrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 simultanagnosia 30.0 APOE MAPT
2 aphasia 29.8 APOE MAPT
3 semantic dementia 29.7 APOE MAPT
4 alzheimer disease 2 29.6 APOE MAPT
5 frontotemporal dementia 29.1 APOE MAPT
6 amyloidosis, primary localized cutaneous, 1 11.2
7 choanal atresia, posterior 11.1
8 primary cutaneous amyloidosis 11.1
9 alzheimer disease 10.7
10 dementia 10.5
11 prostate cancer 10.5
12 prostate cancer, hereditary, 8 10.4
13 prostate cancer, hereditary, 6 10.4
14 pain agnosia 10.3
15 alexia 10.2
16 platelet membrane fluidity 10.2
17 dural sinus malformation 10.2
18 tetralogy of fallot 10.1
19 moyamoya disease 1 10.0
20 adenocarcinoma 10.0
21 agraphia 10.0
22 agnosia 10.0
23 retinitis pigmentosa 10.0
24 coffin-lowry syndrome 10.0
25 intraocular pressure quantitative trait locus 10.0
26 scoliosis 10.0
27 mucositis 10.0
28 patulous eustachian tube 10.0
29 prostatitis 10.0
30 pain - chronic 10.0
31 nodular lymphocyte predominant hodgkin lymphoma 10.0
32 kohlschutter-tonz syndrome 9.9 APOE MAPT
33 alzheimer disease mitochondrial 9.9 APOE MAPT
34 communicating hydrocephalus 9.9 APOE MAPT
35 hydrocephalus 9.9 APOE MAPT
36 hydrocephalus, normal-pressure 9.9 APOE MAPT
37 binswanger's disease 9.9 APOE MAPT
38 brain injury 9.9 APOE MAPT
39 supranuclear palsy, progressive, 1 9.9 APOE MAPT
40 pick disease of brain 9.9 APOE MAPT
41 gilles de la tourette syndrome 9.9
42 down syndrome 9.9
43 aging 9.9
44 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 9.9
45 anxiety 9.9
46 temporal lobe epilepsy 9.9
47 visual agnosia 9.9
48 fuchs' endothelial dystrophy 9.9
49 epilepsy 9.9
50 corneal dystrophy 9.9

Graphical network of the top 20 diseases related to Posterior Cortical Atrophy:



Diseases related to Posterior Cortical Atrophy

Symptoms & Phenotypes for Posterior Cortical Atrophy

Human phenotypes related to Posterior Cortical Atrophy:

60 33 (show all 22)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ataxia 60 33 hallmark (90%) Very frequent (99-80%) HP:0001251
2 anxiety 60 33 hallmark (90%) Very frequent (99-80%) HP:0000739
3 dysgraphia 60 33 hallmark (90%) Very frequent (99-80%) HP:0010526
4 oculomotor apraxia 60 33 hallmark (90%) Very frequent (99-80%) HP:0000657
5 confusion 60 33 hallmark (90%) Very frequent (99-80%) HP:0001289
6 finger agnosia 60 33 hallmark (90%) Very frequent (99-80%) HP:0010525
7 dyscalculia 60 33 hallmark (90%) Very frequent (99-80%) HP:0002442
8 alexia 60 33 hallmark (90%) Very frequent (99-80%) HP:0010523
9 cerebral visual impairment 33 hallmark (90%) HP:0100704
10 photophobia 60 33 frequent (33%) Frequent (79-30%) HP:0000613
11 dyslexia 60 33 frequent (33%) Frequent (79-30%) HP:0010522
12 abnormality of color vision 60 33 frequent (33%) Frequent (79-30%) HP:0000551
13 limb apraxia 60 33 frequent (33%) Frequent (79-30%) HP:0030217
14 memory impairment 60 33 occasional (7.5%) Occasional (29-5%) HP:0002354
15 language impairment 60 33 occasional (7.5%) Occasional (29-5%) HP:0002463
16 visual hallucinations 60 33 occasional (7.5%) Occasional (29-5%) HP:0002367
17 speech apraxia 60 33 occasional (7.5%) Occasional (29-5%) HP:0011098
18 inertia 60 33 occasional (7.5%) Occasional (29-5%) HP:0030216
19 abnormal rapid eye movement sleep 60 33 occasional (7.5%) Occasional (29-5%) HP:0002494
20 abnormality of vision 60 Frequent (79-30%)
21 cortical visual impairment 60 Very frequent (99-80%)
22 agnosia 60 Very frequent (99-80%)

MGI Mouse Phenotypes related to Posterior Cortical Atrophy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 taste/olfaction MP:0005394 8.62 APOE MAPT

Drugs & Therapeutics for Posterior Cortical Atrophy

Search Clinical Trials , NIH Clinical Center for Posterior Cortical Atrophy

Genetic Tests for Posterior Cortical Atrophy

Anatomical Context for Posterior Cortical Atrophy

MalaCards organs/tissues related to Posterior Cortical Atrophy:

42
Cortex, Brain, Eye, Testes, Endothelial, Thyroid, Temporal Lobe

Publications for Posterior Cortical Atrophy

Articles related to Posterior Cortical Atrophy:

(show top 50) (show all 218)
# Title Authors Year
1
A Case of Overlap Posterior Cortical Atrophy and Logopenic Variant Primary Progressive Aphasia. ( 30817493 )
2019
2
18 F-AV-1451 uptake differs between dementia with lewy bodies and posterior cortical atrophy. ( 30615804 )
2019
3
Posterior Cortical Atrophy. ( 30707187 )
2019
4
Relative preservation of facial expression recognition in posterior cortical atrophy. ( 30760634 )
2019
5
Qualitative, exploratory pilot study to investigate how people living with posterior cortical atrophy, their carers and clinicians experience tests used to assess vision. ( 30898793 )
2019
6
Case of posterior cortical atrophy (PCA) evolved to PCA-CBS. ( 29914902 )
2018
7
Prevalence of Mathematical and Visuospatial Learning Disabilities in Patients With Posterior Cortical Atrophy. ( 29630699 )
2018
8
Posterior cortical atrophy: a single case cognitive and radiological follow-up. ( 29308699 )
2018
9
Navigational cue effects in Alzheimer's disease and posterior cortical atrophy. ( 29928653 )
2018
10
Cognitive Rehabilitation and Transcranial Direct Current Stimulation in a Patient with Posterior Cortical Atrophy: An fMRI Study. ( 29925828 )
2018
11
Clinical significance of cognitive rehabilitation and psychoeducational intervention for family caregivers of patients with posterior cortical atrophy: a longitudinal study. ( 29372599 )
2018
12
Methylphenidate Treatment for Patients With Posterior Cortical Atrophy. ( 29685063 )
2018
13
Executive dysfunction contributes to verbal encoding and retrieval deficits in posterior cortical atrophy. ( 29864594 )
2018
14
Differentiation of neuropsychological features between posterior cortical atrophy and early onset Alzheimer's disease. ( 29747584 )
2018
15
Association between precuneus volume and autobiographical memory impairment in posterior cortical atrophy: Beyond the visual syndrome. ( 29876268 )
2018
16
Down syndrome with posterior cortical atrophy. ( 29437810 )
2018
17
Posterior cortical atrophy variant of Alzheimer's dementia-A case report. ( 29864740 )
2018
18
Posterior cortical atrophy: from vision to emotion. ( 29569567 )
2018
19
'Because my brain isn't as active as it should be, my eyes don't always see': a qualitative exploration of the stress process for those living with posterior cortical atrophy. ( 29439072 )
2018
20
A double-blind placebo-controlled cross-over clinical trial of DONepezil In Posterior cortical atrophy due to underlying Alzheimer's Disease: DONIPAD study. ( 29716655 )
2018
21
The rat model of placental ischemia as a model of postpartum posterior cortical atrophy? ( 30323132 )
2018
22
Functional and structural brain networks in posterior cortical atrophy: A two-centre multiparametric MRI study. ( 30013929 )
2018
23
Exploring the contribution of visual imagery to scene construction - Evidence from Posterior Cortical Atrophy. ( 30059847 )
2018
24
Posterior cortical atrophy: A rare variant of Alzheimer's disease. ( 30069290 )
2018
25
Lateral parietal contributions to memory impairment in posterior cortical atrophy. ( 30094173 )
2018
26
Progressive Compromise of Nouns and Action Verbs in Posterior Cortical Atrophy. ( 30123155 )
2018
27
The impact of localized grey matter damage on neighboring connectivity: posterior cortical atrophy and the visual network. ( 30145717 )
2018
28
Electroencephalogram findings in patients with posterior cortical atrophy. ( 30297099 )
2018
29
Atrophy, metabolism and cognition in the posterior cortical atrophy spectrum based on Alzheimer's disease cerebrospinal fluid biomarkers. ( 30340200 )
2018
30
Contributions of patient and citizen researchers to 'Am I the right way up?' study of balance in posterior cortical atrophy and typical Alzheimer's disease. ( 30373456 )
2018
31
A patient with posterior cortical atrophy due to Alzheimer's disease. ( 30425798 )
2018
32
Posterior Cortical Atrophy. ( 30476997 )
2018
33
Intrinsic connectivity networks in posterior cortical atrophy: A role for the pulvinar? ( 30528957 )
2018
34
The Nature and Natural History of Posterior Cortical Atrophy Syndrome: A Variant of Early-onset Alzheimer Disease. ( 28796011 )
2017
35
Homonymous Hemianopsia Due to Posterior Cortical Atrophy. ( 28512507 )
2017
36
A case of posterior cortical atrophy with vertical neglect. ( 28387593 )
2017
37
Lateralized occipital degeneration in posterior cortical atrophy predicts visual field deficits. ( 28180083 )
2017
38
Consensus classification of posterior cortical atrophy. ( 28259709 )
2017
39
Progression of oculomotor deficit in a patient with posterior cortical atrophy. ( 27816183 )
2017
40
Statokinetic Dissociation (Riddoch Phenomenon) in a Patient with Homonymous Hemianopsia as the First Sign of Posterior Cortical Atrophy. ( 29422846 )
2017
41
Tau-PET Binding Distinguishes Patients With Early-stage Posterior Cortical Atrophy From Amnestic Alzheimer Disease Dementia. ( 28394771 )
2017
42
Semantic word category processing in semantic dementia and posterior cortical atrophy. ( 28624681 )
2017
43
Association between low thyroid-stimulating hormone, posterior cortical atrophy and nitro-oxidative stress in elderly patients with cognitive dysfunction. ( 28883858 )
2017
44
Posterior cortical atrophy: the value of neuroimaging in assessing memory loss. ( 29312879 )
2017
45
Posterior cortical atrophy of a suspected non-Alzheimer type: a case report. ( 29072103 )
2017
46
Homonymous hemianopia as the first sign of posterior cortical atrophy. ( 28131221 )
2017
47
The oral spelling profile of posterior cortical atrophy and the nature of the graphemic representation. ( 27913156 )
2017
48
Visual Dysfunction in Posterior Cortical Atrophy. ( 28861031 )
2017
49
F-18 FDG and F-18 Tau PET in posterior cortical atrophy. ( 28584971 )
2017
50
Posterior cortical atrophy as a primary clinical phenotype of corticobasal syndrome with a progranulin gene rs5848 TT genotype. ( 26852323 )
2016

Variations for Posterior Cortical Atrophy

Expression for Posterior Cortical Atrophy

Search GEO for disease gene expression data for Posterior Cortical Atrophy.

Pathways for Posterior Cortical Atrophy

Pathways related to Posterior Cortical Atrophy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 APOE MAPT
2 10.84 APOE MAPT
3 10.28 APOE MAPT

GO Terms for Posterior Cortical Atrophy

Molecular functions related to Posterior Cortical Atrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipoprotein particle binding GO:0071813 8.62 APOE MAPT

Sources for Posterior Cortical Atrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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