PCA
MCID: PST086
MIFTS: 41

Posterior Cortical Atrophy (PCA)

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Posterior Cortical Atrophy

MalaCards integrated aliases for Posterior Cortical Atrophy:

Name: Posterior Cortical Atrophy 59
Biparietal Alzheimer Disease 59
Benson Syndrome 59
Pca 59

Characteristics:

Orphanet epidemiological data:

59
posterior cortical atrophy
Age of onset: Adult; Age of death: adult;

Classifications:

Orphanet: 59  
Rare neurological diseases


Summaries for Posterior Cortical Atrophy

MalaCards based summary : Posterior Cortical Atrophy, also known as biparietal alzheimer disease, is related to simultanagnosia and semantic dementia. An important gene associated with Posterior Cortical Atrophy is CNTNAP5 (Contactin Associated Protein Like 5), and among its related pathways/superpathways are Reelin Pathway (Cajal-Retzius cells) and G-protein signaling_Regulation of RAC1 activity. Affiliated tissues include cortex, brain and eye, and related phenotypes are ataxia and photophobia

Wikipedia : 76 Posterior cortical atrophy (PCA), also called Benson''s syndrome, is a form of dementia which is usually... more...

Related Diseases for Posterior Cortical Atrophy

Diseases related to Posterior Cortical Atrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 simultanagnosia 30.1 APOE MAPT
2 semantic dementia 29.8 APOE MAPT
3 alzheimer disease 2 29.7 APOE MAPT
4 aphasia 29.7 APOE MAPT
5 frontotemporal dementia 29.4 APOE MAPT
6 amyloidosis, primary localized cutaneous, 1 11.2
7 choanal atresia, posterior 11.1
8 primary cutaneous amyloidosis 11.1
9 alzheimer disease 10.7
10 dementia 10.5
11 prostate cancer 10.4
12 alexia 10.2
13 platelet membrane fluidity 10.1
14 pain agnosia 10.1
15 agraphia 10.0
16 agnosia 10.0
17 familial idiopathic basal ganglia calcification 10.0 APOE MAPT
18 kohlschutter-tonz syndrome 10.0 APOE MAPT
19 communicating hydrocephalus 10.0 APOE MAPT
20 moyamoya disease 1 10.0
21 coffin-lowry syndrome 10.0
22 prostatitis 10.0
23 pain - chronic 10.0
24 hydrocephalus 10.0 APOE MAPT
25 hydrocephalus, normal-pressure 10.0 APOE MAPT
26 binswanger's disease 10.0 APOE MAPT
27 brain injury 10.0 APOE MAPT
28 pick disease of brain 10.0 APOE MAPT
29 cerebral amyloid angiopathy, cst3-related 10.0 APOE MAPT
30 inclusion body myositis 10.0 APOE MAPT
31 supranuclear palsy, progressive, 1 10.0 APOE MAPT
32 vascular dementia 9.9 APOE MAPT
33 dementia, lewy body 9.9 APOE MAPT
34 speech and communication disorders 9.9 APOE MAPT
35 disease of mental health 9.9 APOE MAPT
36 creutzfeldt-jakob disease 9.9 APOE MAPT
37 cerebrovascular disease 9.9 APOE MAPT
38 nervous system disease 9.9 APOE MAPT
39 gilles de la tourette syndrome 9.8
40 down syndrome 9.8
41 aging 9.8
42 anxiety 9.8
43 alzheimer disease 19 9.8
44 temporal lobe epilepsy 9.8
45 visual agnosia 9.8
46 fuchs' endothelial dystrophy 9.8
47 epilepsy 9.8
48 corneal dystrophy 9.8
49 ischemia 9.8
50 dyslexia 9.8

Graphical network of the top 20 diseases related to Posterior Cortical Atrophy:



Diseases related to Posterior Cortical Atrophy

Symptoms & Phenotypes for Posterior Cortical Atrophy

Human phenotypes related to Posterior Cortical Atrophy:

59 32 (show all 22)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ataxia 59 32 hallmark (90%) Very frequent (99-80%) HP:0001251
2 photophobia 59 32 frequent (33%) Frequent (79-30%) HP:0000613
3 anxiety 59 32 hallmark (90%) Very frequent (99-80%) HP:0000739
4 memory impairment 59 32 occasional (7.5%) Occasional (29-5%) HP:0002354
5 dyslexia 59 32 frequent (33%) Frequent (79-30%) HP:0010522
6 dysgraphia 59 32 hallmark (90%) Very frequent (99-80%) HP:0010526
7 abnormality of color vision 59 32 frequent (33%) Frequent (79-30%) HP:0000551
8 oculomotor apraxia 59 32 hallmark (90%) Very frequent (99-80%) HP:0000657
9 confusion 59 32 hallmark (90%) Very frequent (99-80%) HP:0001289
10 language impairment 59 32 occasional (7.5%) Occasional (29-5%) HP:0002463
11 finger agnosia 59 32 hallmark (90%) Very frequent (99-80%) HP:0010525
12 visual hallucinations 59 32 occasional (7.5%) Occasional (29-5%) HP:0002367
13 speech apraxia 59 32 occasional (7.5%) Occasional (29-5%) HP:0011098
14 dyscalculia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002442
15 inertia 59 32 occasional (7.5%) Occasional (29-5%) HP:0030216
16 abnormal rapid eye movement sleep 59 32 occasional (7.5%) Occasional (29-5%) HP:0002494
17 alexia 59 32 hallmark (90%) Very frequent (99-80%) HP:0010523
18 limb apraxia 59 32 frequent (33%) Frequent (79-30%) HP:0030217
19 abnormality of vision 59 Frequent (79-30%)
20 cortical visual impairment 59 Very frequent (99-80%)
21 agnosia 59 Very frequent (99-80%)
22 cerebral visual impairment 32 hallmark (90%) HP:0100704

MGI Mouse Phenotypes related to Posterior Cortical Atrophy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 taste/olfaction MP:0005394 8.62 APOE MAPT

Drugs & Therapeutics for Posterior Cortical Atrophy

Search Clinical Trials , NIH Clinical Center for Posterior Cortical Atrophy

Genetic Tests for Posterior Cortical Atrophy

Anatomical Context for Posterior Cortical Atrophy

MalaCards organs/tissues related to Posterior Cortical Atrophy:

41
Cortex, Brain, Eye, Endothelial, Temporal Lobe, Lung, Prostate

Publications for Posterior Cortical Atrophy

Articles related to Posterior Cortical Atrophy:

(show top 50) (show all 213)
# Title Authors Year
1
Case of posterior cortical atrophy (PCA) evolved to PCA-CBS. ( 29914902 )
2018
2
Prevalence of Mathematical and Visuospatial Learning Disabilities in Patients With Posterior Cortical Atrophy. ( 29630699 )
2018
3
Posterior cortical atrophy: a single case cognitive and radiological follow-up. ( 29308699 )
2018
4
Navigational cue effects in Alzheimer's disease and posterior cortical atrophy. ( 29928653 )
2018
5
Cognitive Rehabilitation and Transcranial Direct Current Stimulation in a Patient with Posterior Cortical Atrophy: An fMRI Study. ( 29925828 )
2018
6
Clinical significance of cognitive rehabilitation and psychoeducational intervention for family caregivers of patients with posterior cortical atrophy: a longitudinal study. ( 29372599 )
2018
7
Methylphenidate Treatment for Patients With Posterior Cortical Atrophy. ( 29685063 )
2018
8
Executive dysfunction contributes to verbal encoding and retrieval deficits in posterior cortical atrophy. ( 29864594 )
2018
9
Differentiation of neuropsychological features between posterior cortical atrophy and early onset Alzheimer's disease. ( 29747584 )
2018
10
Association between precuneus volume and autobiographical memory impairment in posterior cortical atrophy: Beyond the visual syndrome. ( 29876268 )
2018
11
Down syndrome with posterior cortical atrophy. ( 29437810 )
2018
12
Posterior cortical atrophy variant of Alzheimer's dementia-A case report. ( 29864740 )
2018
13
Posterior cortical atrophy: from vision to emotion. ( 29569567 )
2018
14
'Because my brain isn't as active as it should be, my eyes don't always see': a qualitative exploration of the stress process for those living with posterior cortical atrophy. ( 29439072 )
2018
15
The rat model of placental ischemia as a model of postpartum posterior cortical atrophy? ( 30323132 )
2018
16
Posterior cortical atrophy of a suspected non-Alzheimer type: a case report. ( 29072103 )
2018
17
A double-blind placebo-controlled cross-over clinical trial of DONepezil In Posterior cortical atrophy due to underlying Alzheimer's Disease: DONIPAD study. ( 29716655 )
2018
18
Functional and structural brain networks in posterior cortical atrophy: A two-centre multiparametric MRI study. ( 30013929 )
2018
19
Exploring the contribution of visual imagery to scene construction - Evidence from Posterior Cortical Atrophy. ( 30059847 )
2018
20
Posterior cortical atrophy: A rare variant of Alzheimer's disease. ( 30069290 )
2018
21
Lateral parietal contributions to memory impairment in posterior cortical atrophy. ( 30094173 )
2018
22
Progressive Compromise of Nouns and Action Verbs in Posterior Cortical Atrophy. ( 30123155 )
2018
23
The impact of localized grey matter damage on neighboring connectivity: posterior cortical atrophy and the visual network. ( 30145717 )
2018
24
Electroencephalogram findings in patients with posterior cortical atrophy. ( 30297099 )
2018
25
Atrophy, metabolism and cognition in the posterior cortical atrophy spectrum based on Alzheimer's disease cerebrospinal fluid biomarkers. ( 30340200 )
2018
26
Contributions of patient and citizen researchers to 'Am I the right way up?' study of balance in posterior cortical atrophy and typical Alzheimer's disease. ( 30373456 )
2018
27
A patient with posterior cortical atrophy due to Alzheimer's disease. ( 30425798 )
2018
28
Posterior Cortical Atrophy. ( 30476997 )
2018
29
Intrinsic connectivity networks in posterior cortical atrophy: A role for the pulvinar? ( 30528957 )
2018
30
The Nature and Natural History of Posterior Cortical Atrophy Syndrome: A Variant of Early-onset Alzheimer Disease. ( 28796011 )
2017
31
Homonymous Hemianopsia Due to Posterior Cortical Atrophy. ( 28512507 )
2017
32
A case of posterior cortical atrophy with vertical neglect. ( 28387593 )
2017
33
Lateralized occipital degeneration in posterior cortical atrophy predicts visual field deficits. ( 28180083 )
2017
34
Consensus classification of posterior cortical atrophy. ( 28259709 )
2017
35
Progression of oculomotor deficit in a patient with posterior cortical atrophy. ( 27816183 )
2017
36
Statokinetic Dissociation (Riddoch Phenomenon) in a Patient with Homonymous Hemianopsia as the First Sign of Posterior Cortical Atrophy. ( 29422846 )
2017
37
Tau-PET Binding Distinguishes Patients With Early-stage Posterior Cortical Atrophy From Amnestic Alzheimer Disease Dementia. ( 28394771 )
2017
38
Semantic word category processing in semantic dementia and posterior cortical atrophy. ( 28624681 )
2017
39
Association between low thyroid-stimulating hormone, posterior cortical atrophy and nitro-oxidative stress in elderly patients with cognitive dysfunction. ( 28883858 )
2017
40
Posterior cortical atrophy: the value of neuroimaging in assessing memory loss. ( 29312879 )
2017
41
The oral spelling profile of posterior cortical atrophy and the nature of the graphemic representation. ( 27913156 )
2017
42
Homonymous hemianopia as the first sign of posterior cortical atrophy. ( 28131221 )
2017
43
F-18 FDG and F-18 Tau PET in posterior cortical atrophy. ( 28584971 )
2017
44
Visual Dysfunction in Posterior Cortical Atrophy. ( 28861031 )
2017
45
Posterior cortical atrophy as a primary clinical phenotype of corticobasal syndrome with a progranulin gene rs5848 TT genotype. ( 26852323 )
2016
46
Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease. ( 26993346 )
2016
47
18F-FDG PET in Posterior Cortical Atrophy and Dementia with Lewy Bodies. ( 27688479 )
2016
48
Clinical and neuroimaging differences between posterior cortical atrophy and typical amnestic Alzheimer's disease patients at an early disease stage. ( 27377199 )
2016
49
Effect of age at onset on cortical thickness and cognition in posterior cortical atrophy. ( 27318138 )
2016
50
Non-pharmacological intervention for posterior cortical atrophy. ( 27574605 )
2016

Variations for Posterior Cortical Atrophy

Expression for Posterior Cortical Atrophy

Search GEO for disease gene expression data for Posterior Cortical Atrophy.

Pathways for Posterior Cortical Atrophy

Pathways related to Posterior Cortical Atrophy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 APOE MAPT
2 10.84 APOE MAPT
3 10.28 APOE MAPT

GO Terms for Posterior Cortical Atrophy

Molecular functions related to Posterior Cortical Atrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipoprotein particle binding GO:0071813 8.62 APOE MAPT

Sources for Posterior Cortical Atrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....