MCID: PST034
MIFTS: 25

Posterior Pituitary Gland Neoplasm

Categories: Cancer diseases, Endocrine diseases
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Aliases & Classifications for Posterior Pituitary Gland Neoplasm

MalaCards integrated aliases for Posterior Pituitary Gland Neoplasm:

Name: Posterior Pituitary Gland Neoplasm 11 14
Neoplasm of the Posterior Pituitary 71
Posterior Pituitary Tumor 11

Classifications:



External Ids:

Disease Ontology 11 DOID:5048
NCIt 49 C7157
UMLS 71 C1334957

Summaries for Posterior Pituitary Gland Neoplasm

MalaCards based summary: Posterior Pituitary Gland Neoplasm, also known as neoplasm of the posterior pituitary, is related to pituitary tumors and keratinizing squamous cell carcinoma. An important gene associated with Posterior Pituitary Gland Neoplasm is NKX2-1 (NK2 Homeobox 1), and among its related pathways/superpathways are BRCA1 Pathway and Transcription Ligand-dependent activation of the ESR1/SP pathway. Affiliated tissues include pituitary, and related phenotypes are Increased proliferation and neoplasm

Related Diseases for Posterior Pituitary Gland Neoplasm

Diseases related to Posterior Pituitary Gland Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 pituitary tumors 10.1
2 keratinizing squamous cell carcinoma 10.1 SMARCB1 NKX2-1
3 small cell carcinoma 10.1 SMARCA4 NKX2-1
4 smarca4-deficient sarcoma of thorax 10.1 SMARCB1 SMARCA4
5 sinonasal undifferentiated carcinoma 10.1 SMARCB1 SMARCA4
6 epithelioid malignant peripheral nerve sheath tumor 10.0 SMARCB1 SMARCA4
7 large cell carcinoma with rhabdoid phenotype 10.0 SMARCB1 SMARCA4
8 ovarian small cell carcinoma 10.0 SMARCB1 SMARCA4
9 kidney rhabdoid cancer 10.0 SMARCB1 SMARCA4
10 rhabdoid cancer 10.0 SMARCB1 SMARCA4
11 juvenile type testicular granulosa cell tumor 10.0 SMARCB1 SMARCA4
12 testicular granulosa cell tumor 10.0 SMARCB1 SMARCA4
13 paranasal sinus cancer 10.0 SMARCB1 SMARCA4
14 malignant teratoma 10.0 SMARCB1 SMARCA4
15 nasal cavity cancer 10.0 SMARCB1 SMARCA4
16 clark-baraitser syndrome 10.0 SMARCB1 SMARCA4
17 lung meningioma 10.0 NKX2-1 NF2
18 autosomal dominant intellectual developmental disorder 9.9 SMARCB1 SMARCA4
19 choroid plexus cancer 9.9 SMARCB1 SMARCA4
20 neurilemmoma 9.9 SMARCB1 NF2
21 full schwannomatosis 9.9 SMARCB1 NF2
22 childhood meningioma 9.9 SMARCB1 NF2
23 peripheral nerve schwannoma 9.9 SMARCB1 NF2
24 pineal region meningioma 9.9 SMARCB1 NF2
25 cerebral falx meningioma 9.9 SMARCB1 NF2
26 parasagittal meningioma 9.9 SMARCB1 NF2
27 cerebral convexity meningioma 9.9 SMARCB1 NF2
28 ovarian clear cell carcinoma 9.9 SMARCB1 SMARCA4
29 optic nerve sheath meningioma 9.9 SMARCB1 NF2
30 plexiform schwannoma 9.9 SMARCB1 NF2
31 schwannomatosis 1 9.9 SMARCB1 NF2
32 olfactory groove meningioma 9.9 SMARCB1 NF2
33 cerebellopontine angle tumor 9.9 SMARCB1 NF2
34 anterior cranial fossa meningioma 9.9 SMARCB1 NF2
35 cellular schwannoma 9.9 SMARCB1 NF2
36 oncocytoma 9.9
37 pituitary adenoma 9.9
38 pituicytoma 9.9
39 chordoid meningioma 9.9 SMARCB1 NF2
40 brain meningioma 9.9 SMARCB1 NF2
41 transitional meningioma 9.9 SMARCB1 NF2
42 atypical neurofibroma 9.9 SMARCB1 NF2
43 secretory meningioma 9.9 SMARCB1 NF2
44 optic nerve neoplasm 9.9 SMARCB1 NF2
45 melanotic neurilemmoma 9.9 SMARCB1 NF2
46 schwannoma of twelfth cranial nerve 9.9 SMARCB1 NF2
47 hypoglossal nerve disease 9.9 SMARCB1 NF2
48 rhabdoid meningioma 9.9 SMARCB1 NF2
49 skull base meningioma 9.9 SMARCB1 NF2
50 spinal canal and spinal cord meningioma 9.9 SMARCB1 NF2

Graphical network of the top 20 diseases related to Posterior Pituitary Gland Neoplasm:



Diseases related to Posterior Pituitary Gland Neoplasm

Symptoms & Phenotypes for Posterior Pituitary Gland Neoplasm

GenomeRNAi Phenotypes related to Posterior Pituitary Gland Neoplasm according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

MGI Mouse Phenotypes related to Posterior Pituitary Gland Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 NF2 NKX2-1 SMARCA4 SMARCB1

Drugs & Therapeutics for Posterior Pituitary Gland Neoplasm

Search Clinical Trials, NIH Clinical Center for Posterior Pituitary Gland Neoplasm

Genetic Tests for Posterior Pituitary Gland Neoplasm

Anatomical Context for Posterior Pituitary Gland Neoplasm

Organs/tissues related to Posterior Pituitary Gland Neoplasm:

MalaCards : Pituitary

Publications for Posterior Pituitary Gland Neoplasm

Articles related to Posterior Pituitary Gland Neoplasm:

# Title Authors PMID Year
1
Granular Cell Tumor and Spindle Cell Oncocytoma of the Pituitary Gland: Imaging and Intraoperative Cytology Diagnostic Dilemmas and Management Challenges. 62
34911085 2022
2
Dabrafenib monotherapy for a recurrent BRAFV600E-mutated TTF-1-positive posterior pituitary tumor. 62
35029761 2022
3
Adenohypophyseal hyperfunction syndromes and posterior pituitary tumors: prevalence, clinical characteristics, and pathophysiological mechanisms. 62
32613546 2020
4
TTF-1 positive posterior pituitary tumor: Limitations of current treatment and potential new hope in BRAF V600E mutation variants. 62
32682222 2020
5
Combined Endoscopic Endonasal and Video-microscopic Transcranial Approach with Preoperative Embolization for a Posterior Pituitary Tumor. 62
30092469 2018

Variations for Posterior Pituitary Gland Neoplasm

Expression for Posterior Pituitary Gland Neoplasm

Search GEO for disease gene expression data for Posterior Pituitary Gland Neoplasm.

Pathways for Posterior Pituitary Gland Neoplasm

Pathways related to Posterior Pituitary Gland Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.32 SMARCB1 SMARCA4
2
Show member pathways
11.21 SMARCB1 SMARCA4
3 11.09 SMARCA4 NKX2-1
4 11 SMARCB1 SMARCA4
5 10.74 SMARCB1 SMARCA4
6
Show member pathways
10.49 SMARCB1 SMARCA4
7 9.8 SMARCB1 SMARCA4

GO Terms for Posterior Pituitary Gland Neoplasm

Cellular components related to Posterior Pituitary Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SWI/SNF complex GO:0016514 9.71 SMARCB1 SMARCA4
2 nBAF complex GO:0071565 9.67 SMARCB1 SMARCA4
3 RSC-type complex GO:0016586 9.62 SMARCB1 SMARCA4
4 npBAF complex GO:0071564 9.56 SMARCB1 SMARCA4
5 bBAF complex GO:0140092 9.46 SMARCB1 SMARCA4
6 DNA packaging complex GO:0044815 8.96 SMARCB1 SMARCA4
7 SWI/SNF superfamily-type complex GO:0070603 8.62 SMARCB1 SMARCA4

Biological processes related to Posterior Pituitary Gland Neoplasm according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 brain development GO:0007420 9.93 SBK1 NKX2-1 NF2
2 positive regulation of stem cell population maintenance GO:1902459 9.83 SMARCB1 SMARCA4
3 positive regulation of myoblast differentiation GO:0045663 9.81 SMARCB1 SMARCA4
4 positive regulation of double-strand break repair GO:2000781 9.8 SMARCB1 SMARCA4
5 positive regulation of T cell differentiation GO:0045582 9.78 SMARCB1 SMARCA4
6 regulation of mitotic metaphase/anaphase transition GO:0030071 9.76 SMARCB1 SMARCA4
7 regulation of nucleotide-excision repair GO:2000819 9.73 SMARCB1 SMARCA4
8 regulation of G0 to G1 transition GO:0070316 9.71 SMARCA4 SMARCB1
9 nucleosome disassembly GO:0006337 9.67 SMARCB1 SMARCA4
10 positive regulation by host of viral transcription GO:0043923 9.62 SMARCB1 SMARCA4
11 RNA polymerase I preinitiation complex assembly GO:0001188 9.56 SMARCB1 SMARCA4
12 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I GO:1901838 9.46 SMARCB1 SMARCA4
13 positive regulation of cell differentiation GO:0045597 9.43 SMARCB1 SMARCA4 NF2
14 positive regulation of glucose mediated signaling pathway GO:1902661 8.92 SMARCB1 SMARCA4

Molecular functions related to Posterior Pituitary Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleosomal DNA binding GO:0031492 9.46 SMARCB1 SMARCA4
2 Tat protein binding GO:0030957 9.26 SMARCB1 SMARCA4
3 RNA polymerase I core promoter sequence-specific DNA binding GO:0001164 8.92 SMARCB1 SMARCA4

Sources for Posterior Pituitary Gland Neoplasm

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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