MCID: PST008
MIFTS: 38

Posterior Scleritis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Posterior Scleritis

MalaCards integrated aliases for Posterior Scleritis:

Name: Posterior Scleritis 12 15 73

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:13676
ICD10 33 H15.03
ICD9CM 35 379.07
SNOMED-CT 68 49429000
UMLS 73 C0155357

Summaries for Posterior Scleritis

MalaCards based summary : Posterior Scleritis is related to temporal arteritis and vasculitis. An important gene associated with Posterior Scleritis is TNFRSF10A (TNF Receptor Superfamily Member 10a), and among its related pathways/superpathways are Immune response Fc epsilon RI pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Infliximab and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include eye, lung and bone, and related phenotypes are cellular and hematopoietic system

Related Diseases for Posterior Scleritis

Diseases in the Scleritis family:

Posterior Scleritis Anterior Scleritis

Diseases related to Posterior Scleritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 temporal arteritis 29.8 TNF TNFRSF10A
2 vasculitis 29.6 PRTN3 TNF
3 systemic lupus erythematosus 28.9 CD19 CD22 PRTN3 TNF
4 scleritis 10.9
5 retinal detachment 10.1
6 uveitis 10.1
7 melanoma 10.1
8 necrobiotic xanthogranuloma 10.1
9 livedoid vasculitis 10.1 PRTN3 TNFRSF10A
10 chronic orbital inflammation 10.1 MRAP PRTN3
11 vogt-koyanagi-harada disease 10.1
12 colon lymphoma 10.0 CD19 CD22
13 small intestine lymphoma 10.0 CD19 CD22
14 central nervous system vasculitis 10.0 TNF TNFRSF10A
15 juvenile ankylosing spondylitis 10.0 MRAP TNF
16 scleral disease 10.0 MRAP TNF
17 pustulosis of palm and sole 10.0 MRAP TNF
18 lung lymphoma 10.0 CD19 CD22
19 post-transplant lymphoproliferative disease 10.0 TNF TNFRSF10A
20 acute salpingitis 10.0 MRAP TNF
21 coccidiosis 10.0 MRAP TNF
22 myositis 10.0
23 arthritis 10.0
24 orbital cellulitis 10.0
25 cellulitis 10.0
26 herpes zoster 10.0
27 anterior uveitis 10.0
28 herpes zoster ophthalmicus 10.0
29 transient arthritis 10.0 MRAP PRTN3 TNFRSF10A
30 inclusion conjunctivitis 10.0 MRAP TNF
31 conjunctival disease 10.0 MRAP TNF
32 lymphoma, hodgkin, classic 10.0 CD19 CD22
33 glaucomatocyclitic crisis 10.0 MRAP TNF
34 panuveitis 9.9 MRAP TNF
35 anca-associated vasculitis 9.9 PRTN3 TNF
36 hypersensitivity reaction type iv disease 9.9 MRAP TNF
37 uveal disease 9.9 MRAP TNF
38 encephalitozoonosis 9.9 CD19 TNF
39 transient hypogammaglobulinemia 9.9 CD19 TNF
40 middle ear disease 9.9 PRTN3 TNF
41 churg-strauss syndrome 9.9 PRTN3 TNF
42 monoclonal gammopathy of uncertain significance 9.9 CD19 TNF
43 spondyloarthropathy 9.9 MRAP TNF
44 spondyloarthropathy 1 9.8 MRAP TNF
45 lateral medullary syndrome 9.8 CD19 CD22 PRTN3
46 appendicitis 9.8 CD19 TNF
47 leukemia, chronic lymphocytic 2 9.8
48 leukemia, chronic lymphocytic 9.8
49 rheumatoid arthritis 9.8
50 sturge-weber syndrome 9.8

Graphical network of the top 20 diseases related to Posterior Scleritis:



Diseases related to Posterior Scleritis

Symptoms & Phenotypes for Posterior Scleritis

MGI Mouse Phenotypes related to Posterior Scleritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.73 CD19 CD22 OGG1 PRTN3 TNF TNFRSF10A
2 hematopoietic system MP:0005397 9.63 CD19 CD22 OGG1 PRTN3 TNF TNFRSF10A
3 immune system MP:0005387 9.43 CD19 CD22 OGG1 PRTN3 TNF TNFRSF10A
4 neoplasm MP:0002006 8.92 CD19 OGG1 TNF TNFRSF10A

Drugs & Therapeutics for Posterior Scleritis

Drugs for Posterior Scleritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 3 170277-31-3
2
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
3
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
4
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
5 Antineoplastic Agents, Hormonal Phase 3
6 Antineoplastic Agents, Alkylating Phase 3
7 Alkylating Agents Phase 3
8 Antirheumatic Agents Phase 3
9 Immunologic Factors Phase 3
10 glucocorticoids Phase 3
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
12 Anti-Inflammatory Agents Phase 3
13 Hormones Phase 3
14 Immunosuppressive Agents Phase 3
15 Gastrointestinal Agents Phase 3
16 Dermatologic Agents Phase 3
17 Hormone Antagonists Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) Not yet recruiting NCT03088293 Phase 3 Infliximab;Cyclophosphamide

Search NIH Clinical Center for Posterior Scleritis

Genetic Tests for Posterior Scleritis

Anatomical Context for Posterior Scleritis

MalaCards organs/tissues related to Posterior Scleritis:

41
Eye, Lung, Bone, Colon, B Cells, Myeloid, Small Intestine

Publications for Posterior Scleritis

Articles related to Posterior Scleritis:

(show top 50) (show all 129)
# Title Authors Year
1
Posterior scleritis follow-up by Swept-Source optical coherence tomography. ( 29169639 )
2018
2
Atypical posterior scleritis mimicking choroidal melanoma. ( 29738013 )
2018
3
Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis. ( 29511745 )
2018
4
Clinical profile of patients with posterior scleritis: A report from Eastern India. ( 30038152 )
2018
5
Commentary: Posterior scleritis: Nuances to discern and handle effectively! ( 30038153 )
2018
6
IgG4-related disease presenting as posterior scleritis and vitritis, progressing to multifocal orbital involvement. ( 28438752 )
2017
7
Posterior Scleritis with Choroidal Effusion Secondary to Herpes Zoster Ophthalmicus. ( 28981391 )
2017
8
Severe Idiopathic Posterior Scleritis in a Patient with HIV. ( 28147399 )
2017
9
Bilateral Posterior Scleritis Associated with Giant Cell Arteritis: A Case Report. ( 28914559 )
2017
10
Trigeminal autonomic cephalgia caused by recurrent posterior scleritis. ( 27495133 )
2016
11
Posterior scleritis in pediatric age group: A case report and review of literature. ( 27013832 )
2016
12
Posterior Scleritis and Necrobiotic Xanthogranuloma. ( 26717063 )
2016
13
A Case of Necrobiotic Xanthogranuloma Presenting as Bilateral Posterior Scleritis. ( 27775456 )
2016
14
Poststreptococcal syndrome presenting as posterior scleritis in a child. ( 28007653 )
2016
15
Isolated posterior scleritis associated with tuberculosis. ( 27224075 )
2016
16
An unusual case of ocular tuberculosis presenting as subretinal abscess with posterior scleritis. ( 27193122 )
2016
17
Posterior scleritis presenting as conjunctivitis in a child. ( 27941114 )
2016
18
An atypical case of bilateral posterior scleritis in a patient with chronic lymphocytic leukemia. ( 26257236 )
2015
19
A case of nodular posterior scleritis mimicking choroidal mass. ( 25892938 )
2015
20
Optical coherence tomography in the management of posterior scleritis. ( 26265857 )
2015
21
NODULAR POSTERIOR SCLERITIS: Clinico-Sonographic Characteristics and Proposed Diagnostic Criteria. ( 26296144 )
2015
22
A case of giant nodular posterior scleritis mimicking choroidal malignancy. ( 26862098 )
2015
23
Bilateral Posterior Scleritis: Analysis of 18 Cases from a Large Cohort of Posterior Scleritis. ( 26471249 )
2015
24
Posterior Scleritis: Analysis of Epidemiology, Clinical Factors, and Risk of Recurrence in a Cohort of 114 Patients. ( 26134101 )
2015
25
Recurrent Unilateral Vogt-Koyanagi-Harada Disease with Posterior Scleritis. ( 26457043 )
2015
26
Posterior Scleritis with Inflammatory Retinal Detachment. ( 26759674 )
2015
27
Nodular Posterior Scleritis Mimicking Choroidal Tumor in a Patient With Systemic Lupus Erythematous: A Case Report and Literature Review. ( 26692258 )
2015
28
Posterior scleritis with retinal pigment epithelium rip: an unusual presentation. ( 25523863 )
2014
29
Choroidal observations in posterior scleritis using high-penetration optical coherence tomography. ( 24398712 )
2014
30
Bilateral Posterior Scleritis Presenting as the First Manifestation of Immunoglobulin A Nephropathy: Case Report and Review of the Literature. ( 25290901 )
2014
31
Bilateral posterior scleritis as a presenting manifestation of giant cell arteritis: A case report. ( 25433749 )
2014
32
Enhanced depth imaging optical coherence tomography of the choroid in recurrent unilateral posterior scleritis. ( 22395202 )
2013
33
Enhanced depth imaging optical coherence tomography of the choroid in new-onset acute posterior scleritis. ( 23381654 )
2013
34
Clinical Features and Presentation of Posterior Scleritis: A Report of 31 Cases. ( 24131324 )
2013
35
Pediatric posterior scleritis. ( 22749104 )
2012
36
Fatal Pneumocystis jirovecii pneumonia following immunosuppressive therapy with rituximab and prednisolone for posterior scleritis. ( 21649871 )
2012
37
Posterior scleritis in a 9-year-old boy: a case report. ( 25390705 )
2012
38
Stellate neuroretinitis associated with posterior scleritis. ( 25390952 )
2012
39
Posterior scleritis in children: clinical features and treatment. ( 22137553 )
2012
40
Posterior scleritis presenting with angle closure glaucoma. ( 22439667 )
2012
41
Combined anterior and posterior scleritis associated with central retinal vein occlusion: a case report. ( 22411459 )
2012
42
Posterior scleritis resembling acute retinal necrosis syndrome. ( 25390725 )
2012
43
Adjunctive globe magnetic resonance imaging in the diagnosis of posterior scleritis. ( 21816252 )
2011
44
Nodular posterior scleritis mimicking choroidal metastasis: a report of two cases. ( 21760715 )
2011
45
Intravitreal bevacizumab (avastin) as an adjuvant for the treatment of posterior scleritis. ( 21860578 )
2011
46
Posterior scleritis in patients with systemic lupus erythematosus. ( 25390910 )
2010
47
Posterior scleritis mimicking orbital cellulitis. ( 20819053 )
2010
48
Bilateral posterior scleritis: an idiopathic painless presentation. ( 20932196 )
2010
49
Bilateral disc swelling associated with posterior scleritis. ( 20508658 )
2010
50
The role of Scheimpflug imaging in the management of posterior scleritis. ( 28539761 )
2010

Variations for Posterior Scleritis

Expression for Posterior Scleritis

Search GEO for disease gene expression data for Posterior Scleritis.

Pathways for Posterior Scleritis

GO Terms for Posterior Scleritis

Cellular components related to Posterior Scleritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.1 CD19 CD22 MRAP PRTN3 TNF TNFRSF10A

Biological processes related to Posterior Scleritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.16 TNF TNFRSF10A
2 extrinsic apoptotic signaling pathway GO:0097191 8.96 TNF TNFRSF10A
3 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 8.62 TNF TNFRSF10A

Molecular functions related to Posterior Scleritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.62 TNF TNFRSF10A

Sources for Posterior Scleritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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