MCID: PST008
MIFTS: 28

Posterior Scleritis

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Posterior Scleritis

MalaCards integrated aliases for Posterior Scleritis:

Name: Posterior Scleritis 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:13676
ICD9CM 34 379.07
SNOMED-CT 67 194144007
ICD10 32 H15.03
UMLS 70 C0155357

Summaries for Posterior Scleritis

MalaCards based summary : Posterior Scleritis is related to scleritis and cogan syndrome. An important gene associated with Posterior Scleritis is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Development_Leptin signaling via JAK/STAT and MAPK cascades and Overview of nanoparticle effects. Affiliated tissues include eye, lymph node and colon.

Related Diseases for Posterior Scleritis

Diseases in the Scleritis family:

Posterior Scleritis Anterior Scleritis

Diseases related to Posterior Scleritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 441)
# Related Disease Score Top Affiliating Genes
1 scleritis 31.3 TNF PRTN3 CRP
2 cogan syndrome 30.5 PRTN3 CRP
3 orbital plasma cell granuloma 30.3 PRTN3 CRP
4 vasculitis 30.3 TNF PRTN3 CRP
5 anterior scleritis 30.3 TNF PRTN3 CRP ACE
6 cellulitis 30.2 TNF CRP
7 retinal vasculitis 30.2 TNF ACE
8 neuroretinitis 30.1 CRP ACE
9 sarcoidosis 1 30.1 TNF CRP ACE
10 macular retinal edema 30.0 VEGFA TNF ACE
11 lymph node tuberculosis 29.9 TNF CRP
12 pustulosis of palm and sole 29.9 TNF CRP
13 cranial nerve palsy 29.8 PRTN3 CRP ACE
14 choroiditis 29.8 VEGFA TNF ACE
15 spondyloarthropathy 1 29.8 TNF PRTN3 CRP
16 proteinuria, chronic benign 29.6 VEGFA ACE
17 pneumonia 29.6 TNF CRP ACE
18 retinal vein occlusion 29.6 VEGFA TNF ACE
19 retinal artery occlusion 29.5 VEGFA CRP ACE
20 branch retinal artery occlusion 29.5 VEGFA PRTN3 CRP
21 psoriatic arthritis 29.4 VEGFA TNF CRP
22 temporal arteritis 29.3 TNFRSF10A TNF PRTN3 CRP
23 endophthalmitis 29.2 VEGFA TNF CRP
24 iridocyclitis 29.2 VEGFA TNFRSF10A TNF CRP ACE
25 connective tissue disease 29.2 VEGFA TNF CRP ACE
26 chorioretinitis 29.0 VEGFA TNF CRP ACE
27 eye disease 28.8 VEGFA TNF IMPG2 CRP
28 systemic lupus erythematosus 28.6 VEGFA TNF PRTN3 CRP ACE
29 retinal detachment 10.7
30 uveitis 10.5
31 exophthalmos 10.3
32 granulomatous myositis 10.3 PRTN3 ACE
33 acute dacryoadenitis 10.2 CRP ACE
34 felty syndrome 10.2 TNFRSF10A PRTN3
35 mediastinum teratoma 10.2 CRP ACE
36 cardiac tuberculosis 10.2 CRP ACE
37 posterior uveitis 10.2
38 silent myocardial infarction 10.2 CRP ACE
39 urinary tract infection 10.2 CRP ACE
40 purulent acute otitis media 10.2 PRTN3 CRP
41 generalized atherosclerosis 10.2 CRP ACE
42 frontal sinusitis 10.2 PRTN3 CRP
43 bicipital tenosynovitis 10.2 PRTN3 CRP
44 ethmoid sinusitis 10.2 PRTN3 CRP
45 intracranial embolism 10.2 CRP ACE
46 cat-scratch disease 10.2 CRP ACE
47 first-degree atrioventricular block 10.2 CRP ACE
48 pulmonary valve insufficiency 10.2 CRP ACE
49 constrictive pericarditis 10.2 CRP ACE
50 splenic tuberculosis 10.2 PRTN3 CRP

Graphical network of the top 20 diseases related to Posterior Scleritis:



Diseases related to Posterior Scleritis

Symptoms & Phenotypes for Posterior Scleritis

Drugs & Therapeutics for Posterior Scleritis

Search Clinical Trials , NIH Clinical Center for Posterior Scleritis

Genetic Tests for Posterior Scleritis

Anatomical Context for Posterior Scleritis

MalaCards organs/tissues related to Posterior Scleritis:

40
Eye, Lymph Node, Colon, Neutrophil

Publications for Posterior Scleritis

Articles related to Posterior Scleritis:

(show top 50) (show all 296)
# Title Authors PMID Year
1
Atypical Sympathetic Ophthalmia Presenting with Ocular Pain Associated with Posterior Scleral Involvement. 61
33734929 2021
2
Bilateral posterior scleritis as a form of presentation of giant cell arteritis. 61
33171310 2021
3
Bisphosphonate-induced Posterior Scleritis. 61
33612163 2021
4
Cilioretinal Artery Occlusion in Posterior Scleritis Secondary to Ankylosing Spondylitis. 61
33626171 2021
5
Prevalence and causes of clinically detectable uveitic serous retinal detachment. 61
33530714 2021
6
Intravitreal dexamethasone implant - a new treatment for idiopathic posterior scleritis: A case report. 61
33521111 2021
7
Posterior scleritis as a rare manifestation of Behçet's disease. 61
33160729 2021
8
Infliximab for management of severe refractory posterior scleritis in a 9-year-old boy. 61
33358990 2020
9
Reactive AA Amyloidosis in the setting of infective endocarditis manifesting as bilateral orbitopathy and choroidopathy. 61
33394958 2020
10
Posterior Scleritis as a Paraneoplastic Syndrome in Colon Cancer: A Case Report 61
33389939 2020
11
Current Approach for the Diagnosis and Management of Noninfective Scleritis. 61
33290287 2020
12
Eye pain in the white and quiet eye. 61
33009080 2020
13
Recurrent posterior scleritis with secondary choroidal osteoma in a child. 61
33120660 2020
14
Segmental Choroidal Vasculitis in Nodular Posterior Scleritis Associated with Polyarteritis Nodosa. 61
32826795 2020
15
Monocular posterior scleritis presenting as acute conjunctivitis: A case report. 61
33195678 2020
16
Exudative Retinal Detachment in Ocular Inflammatory Diseases: Risk and Predictive Factors. 61
32621891 2020
17
Eye pain in the white and quiet eye. 61
32897919 2020
18
A rare case of bilateral sequential posterior scleritis in an elderly woman. 61
32900729 2020
19
Worsening of posterior scleritis and orbital pseudotumor in a patient with granulomatosis polyangiitis with rituximab-A case report. 61
32823451 2020
20
Pediatric Uveitis and Scleritis in a Multi-Ethnic Asian Population. 61
32643984 2020
21
Case report-immune recovery posterior scleritis in a HIV positive patient. 61
32615955 2020
22
Psoriasis-associated progressive necrotizing posterior scleritis: A 6-year follow-up. 61
30638053 2020
23
Tubulointerstitial Nephritis and Uveitis Syndrome: Characterization of Clinical Features. 61
32463299 2020
24
More Than Meets the Eye: A Rare Case of Posterior Scleritis Masquerading as Orbital Cellulitis. 61
32566418 2020
25
Multimodal Imaging of Nodular Posterior Scleritis: Case Report and Review of the Literature. 61
32874049 2020
26
Retinochoroidal fold with severe discedema in a case of posterior scleritis. 61
32174593 2020
27
A case of giant cell arteritis presenting with nodular posterior scleritis mimicking a choroidal mass. 61
32095658 2020
28
Retained intraorbital wooden foreign body presenting with combined anterior and posterior scleritis. 61
32041758 2020
29
VARIX OF A VORTEX VEIN AMPULLA INDUCED BY NODULAR SCLERITIS. 61
31923038 2020
30
Multimodal Imaging in a Case of Localized Suprachoroidal Hemorrhage. 61
32095214 2020
31
Clinical Features, Treatment, and Visual Outcomes of Japanese Patients with Posterior Scleritis. 61
30806525 2020
32
Nodular posterior scleritis associated with presumed ocular tuberculosis: A multimodal imaging case report. 61
31650086 2019
33
Cryopyrin-associated periodic syndrome presenting with posterior scleritis. 61
31170293 2019
34
Tuberculous scleritis in a young Asian Indian girl-a case presentation and literature review. 61
31872314 2019
35
Ocular inflammation associated with relapsing polychondritis in Japanese patients: a review of 11 patients. 61
31077023 2019
36
Point-of-Care Ultrasound in the Evaluation of the Acutely Painful Red Eye. 61
31353264 2019
37
Multimodal imaging in a child with severe posterior scleritis. 61
31915742 2019
38
Posterior Scleritis. 61
31671201 2019
39
Miscellaneous Ocular Symptoms in a Case of Relapsing Polychondritis. 61
31663794 2019
40
Clinical characteristics of scleritis patients with emphasized comparison of associated systemic diseases (anti-neutrophil cytoplasmic antibody-associated vasculitis and rheumatoid arthritis). 61
31183624 2019
41
Tubercular posterior scleritis: A case report and review of literature. 61
31332144 2019
42
Infective conjunctivitis progressing to posterior scleritis. 61
30912241 2019
43
An unusual case of Behcet disease with posterior scleritis: A case report. 61
31464918 2019
44
Commentary: Tubercular posterior scleritis - Nuances in practice! 61
31332146 2019
45
Commentary: Presumed tubercular posterior scleritis - What is our understanding so far? 61
31332145 2019
46
Panscleritis as an Unusual Complication of Gonioscopy-assisted Transluminal Trabeculotomy. 61
30300308 2019
47
The clinical features of posterior scleritis with serous retinal detachment: a retrospective clinical analysis. 61
31341807 2019
48
Orbital Inflammatory Syndrome Post Group A Streptococcal Infection - Case Series and Review of Literature. 61
29020538 2019
49
Posterior Scleritis in Familial Mediterranean Fever. 61
32231554 2019
50
Clinical Features of Scleritis Across the Asia-Pacific Region. 61
29953309 2019

Variations for Posterior Scleritis

Expression for Posterior Scleritis

Search GEO for disease gene expression data for Posterior Scleritis.

Pathways for Posterior Scleritis

Pathways related to Posterior Scleritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.43 VEGFA CRP
2 9.9 TNF CRP

GO Terms for Posterior Scleritis

Cellular components related to Posterior Scleritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.13 TNFRSF10A TNF PRTN3
2 extracellular region GO:0005576 9.1 VEGFA TNF PRTN3 IMPG2 CRP ACE

Biological processes related to Posterior Scleritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.16 TNFRSF10A TNF
2 negative regulation of lipid storage GO:0010888 8.96 TNF CRP
3 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 8.62 VEGFA ACE

Sources for Posterior Scleritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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