MCID: PST041
MIFTS: 41

Posterior Urethral Valves

Categories: Fetal diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Posterior Urethral Valves

MalaCards integrated aliases for Posterior Urethral Valves:

Name: Posterior Urethral Valves 52
Congenital Posterior Urethral Valves 71 32

Classifications:



External Ids:

ICD10 32 Q64.2
UMLS 71 C0238506

Summaries for Posterior Urethral Valves

MalaCards based summary : Posterior Urethral Valves, also known as congenital posterior urethral valves, is related to cakut and congenital anomalies of kidney and urinary tract 2. An important gene associated with Posterior Urethral Valves is BNC2 (Basonuclin 2), and among its related pathways/superpathways are p70S6K Signaling and Dilated cardiomyopathy (DCM). The drugs Fentanyl and Mycophenolic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, appendix and prostate, and related phenotypes are growth/size/body region and behavior/neurological

Related Diseases for Posterior Urethral Valves

Diseases in the Anterior Urethral Valve family:

Posterior Urethral Valves

Diseases related to Posterior Urethral Valves via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 287)
# Related Disease Score Top Affiliating Genes
1 cakut 32.5 TBX18 NRIP1 DSTYK AGTR2
2 congenital anomalies of kidney and urinary tract 2 32.4 TGFB1 TBX18 DSTYK AGTR2
3 renal dysplasia 31.1 AGTR1 AGT ACE
4 oligohydramnios 31.0 AGTR1 AGT ACE
5 acute cystitis 30.8 TNF IL6 ACE
6 potter's syndrome 30.7 AGT ACE
7 hydronephrosis 30.6 TGFB1 TBX18 IL6 AGTR2
8 urinary tract obstruction 30.5 TNF TGFB1 BNC2 AGTR1 ACE
9 anuria 30.2 AGTR1 AGT ACE
10 vesicoureteral reflux 1 30.1 TGFB1 DSTYK AGTR2 AGTR1 AGT ACE
11 ureteral obstruction 30.1 TGFB1 AGTR2 AGTR1
12 uremia 30.1 TNF IL6 ACE
13 end stage renal disease 30.0 TNF IL6 AGTR1 AGT ACE
14 interstitial nephritis 29.9 AGTR1 AGT ACE
15 pyelonephritis 29.9 TNF TGFB1 IL6 ACE
16 obstructive nephropathy 29.7 TGFB1 AGTR2 AGT ACE
17 prostatitis 29.6 TNF TGFB1 IL6
18 renal hypertension 29.2 AGTR2 AGTR1 AGT ACE2 ACE
19 kidney disease 28.2 TGFB1 TBX18 IL6 DSTYK AGTR2 AGTR1
20 chronic kidney disease 28.1 TNF TGFB1 TBX18 IL6 DSTYK AGTR1
21 lower urinary tract obstruction, congenital 12.4
22 congenital anomalies of kidney and urinary tract 1 11.6
23 congenital anomalies of kidney and urinary tract 3 11.5
24 urethral stricture 10.6
25 prune belly syndrome 10.5
26 hypospadias 10.4
27 down syndrome 10.4
28 cryptorchidism, unilateral or bilateral 10.4
29 bladder neck obstruction 10.4
30 idiopathic nephrotic syndrome 10.3 TGFB1 ACE
31 anterior urethral valve 10.3
32 pneumothorax 10.3
33 duplication of urethra 10.3
34 histoplasmosis pericarditis 10.3 TNF ACE
35 kidney hypertrophy 10.3 ACE2 ACE
36 uveoparotid fever 10.2 TNF ACE
37 iga nephropathy 1 10.2 AGTR1 ACE
38 subacute cutaneous lupus erythematosus 10.2 TNF ACE
39 hypertensive encephalopathy 10.2 AGTR1 ACE
40 renal hypodysplasia/aplasia 1 10.2
41 anus, imperforate 10.2
42 renal hypoplasia 10.2
43 renal tubular acidosis 10.2
44 impotence 10.2
45 orchitis 10.2
46 acute kidney failure 10.2
47 infertility 10.2
48 urethral diverticulum 10.2
49 epididymo-orchitis 10.2
50 47,xyy 10.2

Graphical network of the top 20 diseases related to Posterior Urethral Valves:



Diseases related to Posterior Urethral Valves

Symptoms & Phenotypes for Posterior Urethral Valves

MGI Mouse Phenotypes related to Posterior Urethral Valves:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.15 ACE ACE2 AGT AGTR1 AGTR2 BNC2
2 behavior/neurological MP:0005386 10.11 ACE AGT AGTR1 AGTR2 BNC2 DSTYK
3 cardiovascular system MP:0005385 10.09 ACE ACE2 AGT AGTR1 AGTR2 IL6
4 adipose tissue MP:0005375 10.08 ACE AGT AGTR1 AGTR2 IL6 SLC3A1
5 homeostasis/metabolism MP:0005376 10.02 ACE ACE2 AGT AGTR1 AGTR2 IL6
6 digestive/alimentary MP:0005381 9.95 ACE2 AGTR2 BNC2 IL6 NRIP1 TGFB1
7 mortality/aging MP:0010768 9.93 ACE ACE2 AGT AGTR1 AGTR2 BNC2
8 immune system MP:0005387 9.91 ACE ACE2 AGT AGTR1 AGTR2 IL6
9 muscle MP:0005369 9.56 ACE2 AGT AGTR2 IL6 SLC3A1 TBX18
10 renal/urinary system MP:0005367 9.28 ACE ACE2 AGT AGTR1 AGTR2 IL6

Drugs & Therapeutics for Posterior Urethral Valves

Drugs for Posterior Urethral Valves (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
2
Mycophenolic acid Approved Phase 1 24280-93-1 446541
3 Anti-Bacterial Agents Phase 1
4 Anti-Infective Agents Phase 1
5 Antibiotics, Antitubercular Phase 1
6 Antitubercular Agents Phase 1
7 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial of Fetal Cystoscopy Versus Vesico-amniotic Shunting in Severe Lower Urinary Tract Obstructions Unknown status NCT01552824 Phase 2
2 Pilot Study of Mycophenolate Mofetil in Congenital Uropathies Completed NCT00193635 Phase 1 mycophenolate mofetil
3 Study to Compare 2 Minimally Invasive Fetal Neural Tube Defect Repair Techniques: Repair Using Durepair Patch vs. Repair Without Durepair Patch Recruiting NCT03794011 Phase 1
4 Minimally Invasive Fetal Neural Tube Defect Repair Study Active, not recruiting NCT02230072 Phase 1
5 Effect of Circumcision on the Risk of Febrile Urinary Tract Infections in Children With Posterior Urethral Valves. Unknown status NCT01537601
6 Renal Outcome in Children With Congenital Solitary Kidney: a Longitudinal Prognostic Study Unknown status NCT01831141
7 Open Spina Bifida Fetoscopic Repair Project Unknown status NCT03562286
8 Multicentre Validation of a Fetal Urine Peptidome-based Classifier to Predict Post-natal Renal Function in Posterior Urethral Valves Recruiting NCT03116217
9 Validation of the Standardized Prenatal Clinical Management of Fetuses With Lower Urinary Tract Obstruction (LUTO) Recruiting NCT02315521
10 Fetal Cystoscopy for Severe Lower Urinary Tract Obstruction - a Prospective Trial Terminated NCT02446184

Search NIH Clinical Center for Posterior Urethral Valves

Genetic Tests for Posterior Urethral Valves

Anatomical Context for Posterior Urethral Valves

MalaCards organs/tissues related to Posterior Urethral Valves:

40
Kidney, Appendix, Prostate, Colon, Testes, Spinal Cord, Smooth Muscle

Publications for Posterior Urethral Valves

Articles related to Posterior Urethral Valves:

(show top 50) (show all 1200)
# Title Authors PMID Year
1
Retroperitoneoscopic bilateral nephrectomy and extraperitoneal ureterocystoplasty in a child on peritoneal dialysis. 61
32322518 2020
2
Tape: an alternative to stirrups or wedges in positioning for infant cystoscopy. 61
32376291 2020
3
PUVs are more common in boys with hypospadias. 61
32234419 2020
4
Commentary to: Posterior urethral valves are more common in boys with hypospadias. 61
32418780 2020
5
Response to letter to the editor re posterior urethral valves are more common in boys with hypospadias. 61
32513444 2020
6
Anterior Urethral Valve - A Commonly Misdiagnosed Entity in Adolescent Boys. 61
32087211 2020
7
Multi-instance Deep Learning of Ultrasound Imaging Data for Pattern Classification of Congenital Abnormalities of the Kidney and Urinary Tract in Children. 61
32445770 2020
8
Serum creatinine levels in cases of posterior urethral valve: 29 years experience of a pediatric urology reference center. 61
32424984 2020
9
Re: Long-Term Outcome of Pediatric Renal Transplantation in Boys with Posterior Urethral Valves. 61
32407208 2020
10
Posterior Urethral Valves with Lower Urinary Tract Symptoms: Perspective on Urodynamics. 61
32292072 2020
11
Anterior urethral valves - A rare but challenging congenital pathology. 61
32340880 2020
12
Introducing a novel experimental model of bladder transplantation in mice. 61
32282990 2020
13
Challenges in pediatric urologic practice: a lifelong view. 61
32328778 2020
14
Overview of paediatric urology practice in lagos state university teaching hospital, Ikeja, Lagos, Nigeria. 61
32295945 2020
15
Optimal settings for the Holmium: YAG laser in pediatric endourology: Tips and tricks. 61
32224064 2020
16
[Surgical treatment of vesicoureteral reflux in the first year of life?] 61
31805578 2020
17
Vesicoureteral reflux in patients diagnosed with pyeloureteral junction obstruction. Is screening justified? 61
32250069 2020
18
Effect of Early Oxybutynin Treatment on Posterior Urethral Valve Outcomes in Infants: A Randomized Controlled Trial. 61
31821098 2020
19
Persistent myopathy despite release of partial obstruction: in vivo reversal of dysfunction and transcriptional responses using rapamycin. 61
31984552 2020
20
A single-center study to evaluate the efficacy of a fetal urine peptide signature predicting postnatal renal outcome in fetuses with posterior urethral valves. 61
31701236 2020
21
Is there a need for endoscopic evaluation in symptomatic boys with an unsuspicious urethra on VCUG? A consideration of secondary radiologic signs of posterior urethral valves. 61
32232556 2020
22
Re: A Clinical Predictive Model of Chronic Kidney Disease in Children with Posterior Urethral Valves. 61
31710556 2020
23
Adolescent Presentation of Posterior Urethral Valves. 61
31758982 2020
24
Sex effects in pyelonephritis. 61
32040629 2020
25
Long-term Outcome of Renal Transplantation in Patients with Congenital Lower Urinary Tract Malformations: A Multicenter Study. 61
30964838 2020
26
Gross Hematuria as a Presenting Feature of Posterior Urethral Valves in a Neonate with Normal Antenatal Sonograms. 61
31936198 2020
27
Can rectal catheters be avoided during paediatric urodynamic studies? 61
32082633 2020
28
Renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience. 61
31471579 2020
29
Short-Term Outcomes of Treatment of Boys with Posterior Urethral Valves. 61
32180661 2019
30
Survival and Kidney Outcomes of Children with an Early Diagnosis of Posterior Urethral Valves. 61
31582461 2019
31
Balloon catheterization in fetal lower urinary tract obstruction: an observational study of 10 fetuses. 61
31763721 2019
32
Long-term outcome of kidney transplantation in patients with congenital anomalies of the kidney and urinary tract. 61
31309282 2019
33
Cowper's syringocele in the pediatric population: a retrospective study of 122 patients. 61
31270025 2019
34
Can transient resting of the bladder with vesicostomy reduce the need for a major surgery in some patients? 61
31060966 2019
35
Surprising interobserver and intra-observer variability in pediatric testicular ultrasound volumes. 61
31104998 2019
36
Clinical Spectrum of Congenital Anomalies of Kidney and Urinary Tract in Children. 61
31333211 2019
37
Voiding cystography: an unusual route of induced hypothyroidism by iodine overdose in two newborns with chronic kidney disease. 61
30937552 2019
38
Lifelong Congenital Urology: The Challenges for Patients and Surgeons. 61
30935758 2019
39
Developmental pathology of congenital kidney and urinary tract anomalies. 61
31198539 2019
40
The fallow mitrofanoff. 61
30930019 2019
41
Long-term growth in children with posterior urethral valves. 61
30948260 2019
42
The protective arm of the renin-angiotensin system may counteract the intense inflammatory process in fetuses with posterior urethral valves. 61
29534877 2019
43
Prenatal extravasation of urine seems to preserve renal function in boys with posterior urethral valves. 61
30982696 2019
44
Double trouble: A rare case of posterior urethral valve and Cobb's collar. 61
31211059 2019
45
No single reason behind adult lower urinary tract symptoms in patients with posterior urethral valves. 61
31006310 2019
46
Posterior urethral valves: comparison of clinical outcomes between postnatal and antenatal cohorts. 61
30554921 2019
47
A classic twin study of lower urinary tract obstruction: Report of 3 cases and literature review. 61
29664229 2019
48
Population-based trend analysis of voiding cystourethrogram ordering practices in a single-payer healthcare system before and after the release of evaluation guidelines. 61
30718129 2019
49
Outcomes of kidney transplants in pediatric patients with the vertebral defects, anal atresia, cardiac defects, tracheoesophageal fistula, renal anomalies, limb abnormalities association. 61
30597716 2019
50
Re: Caring for Infants with Posterior Urethral Valves: . 61
30759650 2019

Variations for Posterior Urethral Valves

Expression for Posterior Urethral Valves

Search GEO for disease gene expression data for Posterior Urethral Valves.

Pathways for Posterior Urethral Valves

Pathways related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.76 TGFB1 IL6 AGTR2 AGTR1 AGT ACE
2
Show member pathways
11.92 TNF TGFB1 IL6 AGT ACE
3 11.84 TNF TGFB1 IL6
4 11.81 TNF TGFB1 IL6
5
Show member pathways
11.78 TNF IL6 AGT
6
Show member pathways
11.75 TNF TGFB1 IL6
7 11.71 TNF TGFB1 IL6
8 11.67 TNF TGFB1 NRIP1 IL6 AGT
9 11.65 TNF TGFB1 IL6
10 11.54 TNF TGFB1 IL6
11 11.49 AGTR1 AGT ACE
12 11.43 TNF TGFB1 IL6
13 11.35 TNF TGFB1 IL6 AGTR1 AGT
14 11.31 TNF TGFB1 IL6
15 11.01 TNF TGFB1 IL6
16
Show member pathways
11 TGFB1 AGTR2 AGTR1 AGT ACE2 ACE
17 10.87 TNF IL6
18 10.84 TNF NRIP1 IL6
19 10.71 TNF TGFB1
20 10.62 TGFB1 IL6

GO Terms for Posterior Urethral Valves

Biological processes related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.97 TNF TGFB1 IL6 AGTR2 AGTR1
2 positive regulation of transcription, DNA-templated GO:0045893 9.95 TNF TGFB1 NRIP1 IL6 AGTR2 AGT
3 negative regulation of cell growth GO:0030308 9.88 TGFB1 AGTR2 AGT
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 TNF TGFB1 IL6 AGT
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.85 TGFB1 IL6 AGT
6 positive regulation of inflammatory response GO:0050729 9.85 TNF AGTR1 AGT
7 regulation of inflammatory response GO:0050727 9.85 TNF AGTR1 ACE2
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.85 TNF TGFB1 IL6
9 regulation of blood pressure GO:0008217 9.81 AGTR2 AGT ACE
10 negative regulation of fat cell differentiation GO:0045599 9.8 TNF TGFB1 IL6
11 negative regulation of blood vessel endothelial cell migration GO:0043537 9.79 TNF TGFB1 AGTR2
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.78 TNF AGTR2 AGT
13 kidney development GO:0001822 9.76 AGTR2 AGTR1 AGT ACE
14 blood vessel remodeling GO:0001974 9.73 AGTR2 AGT ACE
15 vasodilation GO:0042311 9.72 AGTR2 AGT
16 regulation of cell proliferation GO:0042127 9.72 TNF TGFB1 AGTR1 AGT ACE2
17 positive regulation of chemokine production GO:0032722 9.71 TNF IL6
18 positive regulation of glial cell proliferation GO:0060252 9.71 TNF IL6
19 positive regulation of superoxide anion generation GO:0032930 9.71 TGFB1 AGT
20 nitric oxide mediated signal transduction GO:0007263 9.71 AGTR2 AGT
21 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.71 AGTR1 AGT
22 cellular sodium ion homeostasis GO:0006883 9.7 AGTR2 AGT
23 cell growth involved in cardiac muscle cell development GO:0061049 9.7 AGTR2 AGT
24 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.7 TNF IL6
25 positive regulation of renal sodium excretion GO:0035815 9.69 AGTR2 AGT
26 low-density lipoprotein particle remodeling GO:0034374 9.69 AGTR1 AGT
27 positive regulation of neuroinflammatory response GO:0150078 9.69 TNF IL6
28 angiotensin maturation GO:0002003 9.68 ACE2 ACE
29 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.68 TGFB1 IL6
30 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.67 TNF TGFB1
31 positive regulation of reactive oxygen species metabolic process GO:2000379 9.67 AGTR1 AGT ACE2
32 negative regulation of lipid storage GO:0010888 9.66 TNF IL6
33 regulation of protein import into nucleus GO:0042306 9.66 TGFB1 AGTR2
34 angiotensin-activated signaling pathway GO:0038166 9.65 AGTR2 AGTR1
35 positive regulation of cholesterol esterification GO:0010873 9.65 AGTR1 AGT
36 neutrophil mediated immunity GO:0002446 9.65 IL6 ACE
37 positive regulation of NAD(P)H oxidase activity GO:0033864 9.64 AGTR1 AGT
38 positive regulation of mononuclear cell migration GO:0071677 9.64 TNF TGFB1
39 negative regulation of neurotrophin TRK receptor signaling pathway GO:0051387 9.62 AGTR2 AGT
40 regulation of renal sodium excretion GO:0035813 9.62 AGTR1 AGT
41 positive regulation of extrinsic apoptotic signaling pathway GO:2001238 9.61 TNF AGTR2 AGT
42 positive regulation of gap junction assembly GO:1903598 9.6 AGT ACE2
43 receptor biosynthetic process GO:0032800 9.59 TNF ACE2
44 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.58 AGTR1 AGT
45 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.58 TGFB1 AGTR2 AGT
46 mononuclear cell proliferation GO:0032943 9.55 TGFB1 ACE
47 G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger GO:0007199 9.54 AGTR2 AGT
48 positive regulation of cellular protein metabolic process GO:0032270 9.54 TGFB1 AGTR1 AGT
49 angiotensin-mediated drinking behavior GO:0003051 9.52 AGT ACE2
50 regulation of renal output by angiotensin GO:0002019 9.51 AGT ACE

Molecular functions related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dipeptidyl-peptidase activity GO:0008239 9.32 ACE2 ACE
2 exopeptidase activity GO:0008238 9.26 ACE2 ACE
3 angiotensin type II receptor activity GO:0004945 9.16 AGTR2 AGTR1
4 peptidyl-dipeptidase activity GO:0008241 8.96 ACE2 ACE
5 bradykinin receptor binding GO:0031711 8.62 AGTR1 ACE

Sources for Posterior Urethral Valves

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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