MCID: PST041
MIFTS: 41

Posterior Urethral Valves

Categories: Fetal diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Posterior Urethral Valves

MalaCards integrated aliases for Posterior Urethral Valves:

Name: Posterior Urethral Valves 20
Congenital Posterior Urethral Valves 71 32

Classifications:



External Ids:

ICD10 32 Q64.2
UMLS 71 C0238506

Summaries for Posterior Urethral Valves

MalaCards based summary : Posterior Urethral Valves, also known as congenital posterior urethral valves, is related to congenital anomalies of kidney and urinary tract 2 and urinary tract infection. An important gene associated with Posterior Urethral Valves is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are p70S6K Signaling and Dilated cardiomyopathy. The drugs Fentanyl and Oxybutynin have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and appendix, and related phenotypes are growth/size/body region and cardiovascular system

Related Diseases for Posterior Urethral Valves

Diseases in the Anterior Urethral Valve family:

Posterior Urethral Valves

Diseases related to Posterior Urethral Valves via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 293)
# Related Disease Score Top Affiliating Genes
1 congenital anomalies of kidney and urinary tract 2 31.7 TGFB1 TBX18 DSTYK AGTR2
2 urinary tract infection 31.7 TGFB1 ACE
3 urinary tract obstruction 31.5 TGFB1 BNC2 ACE
4 renal dysplasia 31.4 AGTR1 AGT ACE
5 oligohydramnios 31.3 AGTR1 AGT ACE
6 hydronephrosis 31.0 TGFB1 IL6 AGTR2
7 acute cystitis 31.0 TNF IL6 ACE
8 vesicoureteral reflux 1 30.7 TGFB1 DSTYK AGTR2 AGTR1 AGT ACE
9 potter's syndrome 30.7 AGT ACE
10 pyelonephritis 30.4 TNF IL6 ACE
11 uremia 30.4 TNF IL6 ACE
12 anuria 30.3 AGTR1 AGT ACE
13 interstitial nephritis 30.2 AGTR1 AGT ACE
14 end stage renal disease 30.1 TNF TGFB1 IL6 AGTR1 AGT ACE
15 renal hypertension 30.1 AGTR1 AGT ACE2 ACE
16 ureteral obstruction 30.0 TGFB1 AGTR2 AGTR1
17 cakut 30.0 TBX18 NRIP1 DSTYK AGTR2
18 obstructive nephropathy 29.9 TGFB1 AGTR2 AGT ACE
19 renal hypodysplasia/aplasia 1 29.8 TBX18 DSTYK AGTR2 AGTR1 AGT ACE
20 prostatitis 29.7 TNF TGFB1 IL6
21 orchitis 29.7 TNF IL6 ACE2
22 respiratory failure 29.7 TNF IL6 ACE2 ACE
23 chronic kidney disease 29.2 TNF TGFB1 TBX18 IL6 DSTYK AGTR1
24 kidney disease 28.5 TNF TGFB1 TBX18 IL6 DSTYK AGTR2
25 lower urinary tract obstruction, congenital 11.4
26 congenital anomalies of kidney and urinary tract 1 11.4
27 congenital anomalies of kidney and urinary tract 3 11.2
28 urethral stricture 10.6
29 prune belly syndrome 10.5
30 proteinuria, chronic benign 10.5
31 hypospadias 10.5
32 cryptorchidism, unilateral or bilateral 10.5
33 bladder neck obstruction 10.5
34 down syndrome 10.4
35 47,xyy 10.4
36 anterior urethral valve 10.4
37 pneumothorax 10.3
38 impotence 10.3
39 hypertensive encephalopathy 10.3 AGTR1 ACE
40 renal hypoplasia 10.3
41 acute kidney failure 10.3
42 urethral diverticulum 10.3
43 duplication of urethra 10.3
44 hypertensive retinopathy 10.2 AGTR1 ACE
45 meningococcal infection 10.2 AGTR1 AGT
46 intracranial vasospasm 10.2 AGTR2 ACE
47 aldosterone-producing adenoma 10.2 AGTR2 AGTR1
48 anterior scleritis 10.2 TNF ACE
49 alzheimer disease 5 10.2 AGTR1 ACE
50 posterior scleritis 10.2 TNF ACE

Graphical network of the top 20 diseases related to Posterior Urethral Valves:



Diseases related to Posterior Urethral Valves

Symptoms & Phenotypes for Posterior Urethral Valves

MGI Mouse Phenotypes related to Posterior Urethral Valves:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.15 ACE ACE2 AGT AGTR1 AGTR2 BNC2
2 cardiovascular system MP:0005385 10.09 ACE ACE2 AGT AGTR1 AGTR2 IL6
3 adipose tissue MP:0005375 10.06 ACE AGT AGTR1 AGTR2 IL6 SLC3A1
4 mortality/aging MP:0010768 10.03 ACE ACE2 AGT AGTR1 AGTR2 BNC2
5 immune system MP:0005387 9.97 ACE ACE2 AGT AGTR1 AGTR2 IL6
6 digestive/alimentary MP:0005381 9.95 ACE2 AGTR2 BNC2 IL6 NRIP1 TGFB1
7 muscle MP:0005369 9.76 ACE2 AGT AGTR2 IL6 SLC3A1 TBX18
8 nervous system MP:0003631 9.65 ACE AGT AGTR1 AGTR2 BNC2 DSTYK
9 renal/urinary system MP:0005367 9.28 ACE ACE2 AGT AGTR1 AGTR2 IL6

Drugs & Therapeutics for Posterior Urethral Valves

Drugs for Posterior Urethral Valves (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
2
Oxybutynin Approved, Investigational Phase 2 5633-20-5 4634
3 Parasympatholytics Phase 2
4 Liver Extracts Phase 2
5 Cholinergic Antagonists Phase 2
6 Muscarinic Antagonists Phase 2
7 Neurotransmitter Agents Phase 2
8 Cholinergic Agents Phase 2
9 Antibiotics, Antitubercular
10 Anti-Infective Agents
11 Anti-Bacterial Agents
12 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial of Fetal Cystoscopy Versus Vesico-amniotic Shunting in Severe Lower Urinary Tract Obstructions Unknown status NCT01552824 Phase 2
2 Prospective Randomized Clinical Trial of Early Oxybutinin Treatment for Boys With Posterior Urethral Valves Not yet recruiting NCT04526353 Phase 2 Oxybutynin 1 mg/ml Syrup
3 Effect of Circumcision on the Risk of Febrile Urinary Tract Infections in Children With Posterior Urethral Valves. Unknown status NCT01537601
4 Validation of the Standardized Prenatal Clinical Management of Fetuses With Lower Urinary Tract Obstruction (LUTO) Recruiting NCT02315521
5 Multicentre Validation of a Fetal Urine Peptidome-based Classifier to Predict Post-natal Renal Function in Posterior Urethral Valves Recruiting NCT03116217
6 Fetal Cystoscopy for Severe Lower Urinary Tract Obstruction - a Prospective Trial Terminated NCT02446184

Search NIH Clinical Center for Posterior Urethral Valves

Genetic Tests for Posterior Urethral Valves

Anatomical Context for Posterior Urethral Valves

MalaCards organs/tissues related to Posterior Urethral Valves:

40
Liver, Kidney, Appendix, Smooth Muscle, Prostate, Spinal Cord, Testis

Publications for Posterior Urethral Valves

Articles related to Posterior Urethral Valves:

(show top 50) (show all 1221)
# Title Authors PMID Year
1
Sex effects in pyelonephritis. 61
32040629 2021
2
The impact of caring for children with posterior urethral valves. 61
32744791 2021
3
Role of a Pre-Operative Catheter Regimen in Achieving Early Primary Endoscopic Valve Ablation in Neonates With Posterior Urethral Valves. 61
33530747 2021
4
Evaluation of polyuria and polydipsia along with other established prognostic factors in posterior urethral valves for progression to kidney failure: experience from a developing country. 61
33462698 2021
5
Is there a need for endoscopic evaluation in symptomatic boys with an unsuspicious urethra on VCUG? A consideration of secondary radiologic signs of posterior urethral valves. 61
32232556 2021
6
COVID-19 in Children With Kidney Disease: A Report of 2 Cases. 61
33251504 2021
7
Evaluation of boys with daytime incontinence by combined cystourethroscopy, voiding cystourethrography and urodynamics. 61
33377406 2020
8
"When ablation goes wrong"- urethral strictures after ablation of posterior urethral valves-characteristics, management and outcomes". 61
32981860 2020
9
Comparative outcome analysis of pediatric kidney transplant in posterior urethral valves children with or without pretransplant Mitrofanoff procedure. 61
32741040 2020
10
Comparison of the amniotic fluid and fetal urine peptidome for biomarker discovery in renal developmental disease. 61
33303833 2020
11
Urethroplasty with balloon catheterization in fetal lower urinary tract obstruction: observational study of 10 fetuses. 61
31763721 2020
12
Association of Renal Glomerular and Tubular Function With Renal Outcome in Patients With Posterior Urethral Valves. 61
33296697 2020
13
Introducing a novel experimental model of bladder transplantation in mice. 61
32282990 2020
14
Antenatal biological models in the characterization and research of congenital lower urinary tract disorders. 61
33386226 2020
15
ACR Appropriateness Criteria® Antenatal Hydronephrosis-Infant. 61
33153550 2020
16
Fetal bladder outflow obstruction: Interventions, outcomes and management uncertainties. 61
32978001 2020
17
Contractile function of detrusor smooth muscle from children with posterior urethral valves - The role of fibrosis. 61
33214068 2020
18
Renal, Bladder and Sexual Outcomes in Adult Men with History of Posterior Urethral Valves Treated in Childhood. 61
33188791 2020
19
Anterior urethral valves - A rare but challenging congenital pathology. 61
32340880 2020
20
Posterior urethral valves and hypospadias: What about voiding dysfunction? 61
32798108 2020
21
Response to letter to the Editor re 'Posterior urethral valves are more common in boys with hypospadias'. 61
32900636 2020
22
Serum creatinine levels in cases of posterior urethral valve: 29 years experience of a pediatric urology reference center. 61
32424984 2020
23
Primary infertility secondary to a hidden posterior urethral valve representing a diagnostic challenge in the fifth decade. 61
32893284 2020
24
Re: Long-Term Outcome of Pediatric Renal Transplantation in Boys with Posterior Urethral Valves. 61
32407208 2020
25
Are pressure pop-offs beneficial to the bladder in boys with posterior urethral valves? 61
32605875 2020
26
Multi-instance Deep Learning of Ultrasound Imaging Data for Pattern Classification of Congenital Abnormalities of the Kidney and Urinary Tract in Children. 61
32445770 2020
27
Role of Urinary Transforming Growth Factor Beta-B1 and Monocyte Chemotactic Protein-1 as Prognostic Biomarkers in Posterior Urethral Valve. 61
32939113 2020
28
Posterior Urethral Valves Consensus. 61
32939127 2020
29
Retroperitoneoscopic bilateral nephrectomy and extraperitoneal ureterocystoplasty in a child on peritoneal dialysis. 61
32322518 2020
30
Unusual fetal ascites and spontaneous bladder rupture in a female fetus: a case report. 61
32684161 2020
31
Tape: an alternative to stirrups or wedges in positioning for infant cystoscopy. 61
32376291 2020
32
Anterior Urethral Valve - A Commonly Misdiagnosed Entity in Adolescent Boys. 61
32087211 2020
33
The ANTENATAL multicentre study to predict postnatal renal outcome in fetuses with posterior urethral valves: objectives and design. 61
32699617 2020
34
Response to letter to the editor re posterior urethral valves are more common in boys with hypospadias. 61
32513444 2020
35
Commentary to: Posterior urethral valves are more common in boys with hypospadias. 61
32418780 2020
36
PUVs are more common in boys with hypospadias. 61
32234419 2020
37
Challenges in pediatric urologic practice: a lifelong view. 61
32328778 2020
38
Effect of Early Oxybutynin Treatment on Posterior Urethral Valve Outcomes in Infants: A Randomized Controlled Trial. 61
31821098 2020
39
Overview of paediatric urology practice in lagos state university teaching hospital, Ikeja, Lagos, Nigeria. 61
32295945 2020
40
Optimal settings for the Holmium: YAG laser in pediatric endourology: Tips and tricks. 61
32224064 2020
41
Vesicoureteral reflux in patients diagnosed with pyeloureteral junction obstruction. Is screening justified? 61
32250069 2020
42
[Surgical treatment of vesicoureteral reflux in the first year of life?] 61
31805578 2020
43
Posterior Urethral Valves with Lower Urinary Tract Symptoms: Perspective on Urodynamics. 61
32292072 2020
44
A single-center study to evaluate the efficacy of a fetal urine peptide signature predicting postnatal renal outcome in fetuses with posterior urethral valves. 61
31701236 2020
45
Persistent myopathy despite release of partial obstruction: in vivo reversal of dysfunction and transcriptional responses using rapamycin. 61
31984552 2020
46
Adolescent Presentation of Posterior Urethral Valves. 61
31758982 2020
47
Re: A Clinical Predictive Model of Chronic Kidney Disease in Children with Posterior Urethral Valves. 61
31710556 2020
48
Can rectal catheters be avoided during paediatric urodynamic studies? 61
32082633 2020
49
Can the posterior:anterior urethral ratio on voiding cystourethrogram be used as a reliable predictor of successful posterior urethral valve ablation in male children? 61
32670630 2020
50
Renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience. 61
31471579 2020

Variations for Posterior Urethral Valves

Expression for Posterior Urethral Valves

Search GEO for disease gene expression data for Posterior Urethral Valves.

Pathways for Posterior Urethral Valves

Pathways related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.76 TGFB1 IL6 AGTR2 AGTR1 AGT ACE
2
Show member pathways
11.92 TNF TGFB1 IL6 AGT ACE
3 11.85 TNF TGFB1 IL6
4 11.82 TNF TGFB1 IL6
5
Show member pathways
11.78 TNF IL6 AGT
6 11.73 TNF TGFB1 IL6
7 11.68 TNF TGFB1 IL6
8 11.67 TNF TGFB1 NRIP1 IL6 AGT
9
Show member pathways
11.58 TNF TGFB1 IL6
10 11.56 TNF TGFB1 IL6
11 11.51 AGTR1 AGT ACE
12 11.47 TNF TGFB1 IL6
13 11.43 TNF TGFB1 IL6
14 11.35 TNF TGFB1 IL6 AGTR1 AGT
15 11.31 TNF TGFB1 IL6
16 11.01 TNF TGFB1 IL6
17
Show member pathways
11 TGFB1 AGTR2 AGTR1 AGT ACE2 ACE
18 10.88 TNF IL6
19 10.84 TNF NRIP1 IL6
20 10.72 TNF TGFB1
21 10.64 TGFB1 IL6

GO Terms for Posterior Urethral Valves

Biological processes related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.96 TNF TGFB1 IL6 AGTR2 AGTR1
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 TNF TGFB1 IL6 AGT
3 negative regulation of cell growth GO:0030308 9.87 TGFB1 AGTR2 AGT
4 positive regulation of inflammatory response GO:0050729 9.85 TNF AGTR1 AGT
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.85 TGFB1 IL6 AGT
6 regulation of inflammatory response GO:0050727 9.85 TNF AGTR1 ACE2
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.84 TNF TGFB1 IL6
8 kidney development GO:0001822 9.84 AGTR2 AGTR1 AGT ACE
9 regulation of blood pressure GO:0008217 9.81 AGTR2 AGT ACE
10 negative regulation of fat cell differentiation GO:0045599 9.8 TNF TGFB1 IL6
11 negative regulation of signaling receptor activity GO:2000272 9.78 TNF AGTR2 ACE2
12 negative regulation of blood vessel endothelial cell migration GO:0043537 9.77 TNF TGFB1 AGTR2
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 TNF AGTR2 AGT
14 blood vessel remodeling GO:0001974 9.72 AGTR2 AGT ACE
15 regulation of cell proliferation GO:0042127 9.72 TNF TGFB1 AGTR1 AGT ACE2
16 positive regulation of superoxide anion generation GO:0032930 9.71 TGFB1 AGT
17 positive regulation of blood vessel diameter GO:0097755 9.71 AGTR2 AGT
18 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.71 AGTR1 AGT
19 positive regulation of glial cell proliferation GO:0060252 9.71 TNF IL6
20 positive regulation of interleukin-17 production GO:0032740 9.71 TGFB1 IL6
21 nitric oxide mediated signal transduction GO:0007263 9.7 AGTR2 AGT
22 low-density lipoprotein particle remodeling GO:0034374 9.7 AGTR1 AGT
23 cell growth involved in cardiac muscle cell development GO:0061049 9.7 AGTR2 AGT
24 positive regulation of reactive oxygen species metabolic process GO:2000379 9.7 AGTR1 AGT ACE2
25 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.69 TNF IL6
26 positive regulation of renal sodium excretion GO:0035815 9.69 AGTR2 AGT
27 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.69 TGFB1 IL6
28 positive regulation of neuroinflammatory response GO:0150078 9.68 TNF IL6
29 angiotensin maturation GO:0002003 9.68 ACE2 ACE
30 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.68 TNF TGFB1
31 neutrophil mediated immunity GO:0002446 9.67 IL6 ACE
32 regulation of protein import into nucleus GO:0042306 9.66 TGFB1 AGTR2
33 angiotensin-activated signaling pathway GO:0038166 9.65 AGTR2 AGTR1
34 negative regulation of lipid storage GO:0010888 9.65 TNF IL6
35 positive regulation of cholesterol esterification GO:0010873 9.65 AGTR1 AGT
36 positive regulation of NAD(P)H oxidase activity GO:0033864 9.64 AGTR1 AGT
37 vascular endothelial growth factor production GO:0010573 9.64 TNF IL6
38 positive regulation of mononuclear cell migration GO:0071677 9.63 TNF TGFB1
39 negative regulation of neurotrophin TRK receptor signaling pathway GO:0051387 9.62 AGTR2 AGT
40 regulation of renal sodium excretion GO:0035813 9.61 AGTR1 AGT
41 positive regulation of extrinsic apoptotic signaling pathway GO:2001238 9.61 TNF AGTR2 AGT
42 positive regulation of gap junction assembly GO:1903598 9.58 AGT ACE2
43 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.58 TGFB1 AGTR2 AGT
44 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.57 AGTR1 AGT
45 positive regulation of cellular protein metabolic process GO:0032270 9.54 TGFB1 AGTR1 AGT
46 mononuclear cell proliferation GO:0032943 9.51 TGFB1 ACE
47 G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger GO:0007199 9.49 AGTR2 AGT
48 angiotensin-mediated drinking behavior GO:0003051 9.48 AGT ACE2
49 regulation of renal output by angiotensin GO:0002019 9.46 AGT ACE
50 regulation of blood vessel diameter GO:0097746 9.46 AGTR2 AGTR1 ACE2 ACE

Molecular functions related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 angiotensin type II receptor activity GO:0004945 9.16 AGTR2 AGTR1
2 peptidyl-dipeptidase activity GO:0008241 8.96 ACE2 ACE
3 bradykinin receptor binding GO:0031711 8.62 AGTR1 ACE

Sources for Posterior Urethral Valves

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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