MCID: PST022
MIFTS: 39

Posterior Uveal Melanoma

Categories: Cancer diseases, Neuronal diseases, Eye diseases, Skin diseases, Rare diseases

Aliases & Classifications for Posterior Uveal Melanoma

MalaCards integrated aliases for Posterior Uveal Melanoma:

Name: Posterior Uveal Melanoma 12 15
Ciliary Body and Choroid Melanoma, Medium/large Size 73
Ciliary Body and Choroid Melanoma, Small Size 73
Medium/large Size Posterior Uveal Melanoma 12
Small Size Posterior Uveal Melanoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6566
NCIt 50 C9089 C9090

Summaries for Posterior Uveal Melanoma

MalaCards based summary : Posterior Uveal Melanoma, also known as ciliary body and choroid melanoma, medium/large size, is related to melanoma, uveal and melanoma. An important gene associated with Posterior Uveal Melanoma is THBS2 (Thrombospondin 2), and among its related pathways/superpathways are Pathways in cancer and Glioma. The drugs Dacarbazine and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include eye, liver and testes, and related phenotypes are hematopoietic system and immune system

Related Diseases for Posterior Uveal Melanoma

Diseases in the Melanoma, Uveal family:

Melanoma, Uveal 1 Melanoma, Uveal 2
Posterior Uveal Melanoma

Diseases related to Posterior Uveal Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 melanoma, uveal 30.0 MITF THBS1
2 melanoma 10.9
3 choroiditis 10.0
4 endotheliitis 10.0
5 retinal detachment 9.9
6 retinoblastoma 9.9
7 microphthalmia 9.9
8 retinitis 9.9
9 thyroiditis 9.9
10 macular holes 9.9
11 cell type cancer 9.8 MITF VEGFA
12 vascular cancer 9.6 THBS1 VEGFA
13 arteriovenous malformations of the brain 9.6 THBS1 VEGFA
14 corneal neovascularization 9.5 THBS1 VEGFA
15 peters-plus syndrome 9.3 THBS1 THBS2

Graphical network of the top 20 diseases related to Posterior Uveal Melanoma:



Diseases related to Posterior Uveal Melanoma

Symptoms & Phenotypes for Posterior Uveal Melanoma

MGI Mouse Phenotypes related to Posterior Uveal Melanoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.72 VEGFA CCND2 MITF THBS1 THBS2
2 immune system MP:0005387 9.65 VEGFA CCND2 MITF THBS1 THBS2
3 integument MP:0010771 9.46 THBS2 VEGFA MITF THBS1
4 limbs/digits/tail MP:0005371 9.26 VEGFA MITF THBS1 THBS2
5 vision/eye MP:0005391 8.92 VEGFA CCND2 MITF THBS1

Drugs & Therapeutics for Posterior Uveal Melanoma

Drugs for Posterior Uveal Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
2
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
3
Imidazole Experimental, Investigational Phase 2 288-32-4 795
4 Alkylating Agents Phase 2
5 Antineoplastic Agents, Alkylating Phase 2
6 Liver Extracts Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Temozolomide or Selumetinib in Treating Patients With Metastatic Melanoma of the Eye Completed NCT01143402 Phase 2 Dacarbazine;Selumetinib;Temozolomide
2 Radiation Therapy in Preventing Liver Metastases in Patients With Uveal Melanoma Who HaveMonosomy 3 or DecisionDx Class 2 Disease and Are More Likely to Develop Liver Metastases Terminated NCT02336763 Not Applicable
3 Validation of a Molecular Prognostic Test for Eye Melanoma Withdrawn NCT00406120

Search NIH Clinical Center for Posterior Uveal Melanoma

Genetic Tests for Posterior Uveal Melanoma

Anatomical Context for Posterior Uveal Melanoma

MalaCards organs/tissues related to Posterior Uveal Melanoma:

41
Eye, Liver, Testes, Endothelial, Thyroid

Publications for Posterior Uveal Melanoma

Articles related to Posterior Uveal Melanoma:

(show top 50) (show all 100)
# Title Authors Year
1
Plaque brachytherapy for posterior uveal melanoma in 2018: improved techniques and expanded indications. ( 29538180 )
2018
2
Unsuspected and misdiagnosed posterior uveal melanoma following enucleation and evisceration in Ottawa-Gatineau. ( 29631828 )
2018
3
Long-Term Metastatic Risk after Biopsy of Posterior Uveal Melanoma. ( 29705056 )
2018
4
Visual outcome after posterior uveal melanoma episcleral brachytherapy including radiobiological doses. ( 29789761 )
2018
5
INTRAVITREAL DEXAMETHASONE (OZURDEX) IMPLANT FOR RADIATION MACULOPATHY SECONDARY TO STEREOTACTIC RADIOTHERAPY FOR POSTERIOR UVEAL MELANOMA. ( 28489707 )
2017
6
Local Failure After Episcleral Brachytherapy for Posterior Uveal Melanoma: Patterns, Risk Factors, and Management. ( 28163118 )
2017
7
Local Failure After Episcleral Brachytherapy for Posterior Uveal Melanoma: Patterns, Risk Factors, and Management. ( 28756956 )
2017
8
Independent Prognostic Significance of Gene Expression Profile Class and Largest Basal Diameter of Posterior Uveal Melanomas. ( 26596399 )
2016
9
Repeat Episcleral Plaque Brachytherapy: Clinical Outcomes in Patients Treated for Locally Recurrent Posterior Uveal Melanoma. ( 28048976 )
2016
10
Clinical application of genetic testing for posterior uveal melanoma. ( 27847622 )
2016
11
Management of posterior uveal melanoma: past, present, and future: the 2014 Charles L. Schepens lecture. ( 25439609 )
2015
12
Frequency and implications of discordant gene expression profile class in posterior uveal melanomas sampled by fine needle aspiration biopsy. ( 25448994 )
2015
13
Sufficiency of FNAB aspirates of posterior uveal melanoma for cytologic versus GEP classification in 159 patients, and relative prognostic significance of these classifications. ( 24270974 )
2014
14
Relationship between rate of posterior uveal melanoma flattening following plaque radiotherapy and GEP class of tumor cells. ( 24408979 )
2014
15
Treatment of posterior uveal melanoma with multi-dose photodynamic therapy. ( 24463441 )
2014
16
Diffusion restriction of posterior uveal melanoma on MR imaging. ( 25597216 )
2014
17
Gamma-knife-based stereotactic radiosurgery for medium- and large-sized posterior uveal melanoma. ( 22944897 )
2013
18
Long-term followup comparing two treatment dosing strategies of (125) I plaque radiotherapy in the management of small/medium posterior uveal melanoma. ( 23533708 )
2013
19
American Joint Committee on Cancer classification of posterior uveal melanoma (tumor size category) predicts prognosis in 7731 patients. ( 23664467 )
2013
20
Genome-wide profiling is a clinically relevant and affordable prognostic test in posterior uveal melanoma. ( 24169649 )
2013
21
Intravitreal triamcinolone versus intravitreal bevacizumab in the treatment of exudative retinal detachment secondary to posterior uveal melanoma. ( 22995029 )
2013
22
Combination therapy with triamcinolone acetonide and bevacizumab for the treatment of severe radiation maculopathy in patients with posterior uveal melanoma. ( 24092966 )
2013
23
Tumor-related lipid exudation and associated tumor-related complications after plaque radiotherapy of posterior uveal melanoma. ( 23483500 )
2013
24
Posterior uveal melanoma coexistent with macular hole. ( 23604299 )
2013
25
One-day session LINAC-based stereotactic radiosurgery of posterior uveal melanoma. ( 21534252 )
2012
26
Evaluation of the surgical learning curve for I-125 episcleral plaque placement for the treatment of posterior uveal melanoma: a two decade review. ( 22536035 )
2012
27
Safety of pars plana vitrectomy in eyes with plaque-irradiated posterior uveal melanoma. ( 23044941 )
2012
28
Role of microRNA-182 in posterior uveal melanoma: regulation of tumor development through MITF, BCL2 and cyclin D2. ( 22848417 )
2012
29
Carcinoembryonic antigen cell adhesion molecule-1 (CEACAM1) in posterior uveal melanoma: correlation with clinical and histological survival markers. ( 22039239 )
2011
30
Posterior uveal melanoma in young patients treated with proton beam therapy. ( 20224468 )
2010
31
No differences in outcome between radical surgical treatment (enucleation) and stereotactic radiosurgery in patients with posterior uveal melanoma. ( 20429631 )
2010
32
Update on posterior uveal melanoma: treatment of the eye and emerging strategies in the prognosis and treatment of metastatic disease. ( 19644367 )
2009
33
Ruthenium-106 plaque brachytherapy for thick posterior uveal melanomas. ( 19570767 )
2009
34
A reappraisal of the significance of largest basal diameter of posterior uveal melanoma. ( 19876071 )
2009
35
The T1799A point mutation is present in posterior uveal melanoma. ( 18985043 )
2008
36
Posterior uveal melanoma. Distribution of the sites of origin and patterns of tumour extent in the ocular fundus. ( 18523080 )
2008
37
Posterior uveal melanoma treated with I-125 brachytherapy or primary enucleation. ( 17585309 )
2008
38
In vivo monosomy 3 detection of posterior uveal melanoma: 3-year follow-up. ( 17934749 )
2008
39
Expression of vascular endothelial growth factor-A, matrix metalloproteinase-9, and extravascular matrix patterns and their correlations with clinicopathologic parameters in posterior uveal melanomas. ( 17926107 )
2007
40
Lipid exudation following plaque radiotherapy for posterior uveal melanoma. ( 16490526 )
2006
41
Apoptosis inhibitor, survivin, in posterior uveal melanoma: comparison among primary tumors, tumors resistant to brachytherapy, tumors with liver metastases, and liver metastases. ( 16531282 )
2006
42
Proton or stereotactic photon irradiation for posterior uveal melanoma? A planning intercomparison. ( 16362788 )
2005
43
18 years' experience with high dose rate strontium-90 brachytherapy of small to medium sized posterior uveal melanoma. ( 16170122 )
2005
44
Genomic investigations of posterior uveal melanoma. ( 16352494 )
2005
45
Differential expression of angioregulatory matricellular proteins in posterior uveal melanoma. ( 16314734 )
2005
46
Association between posterior uveal melanoma and iris freckles, iris naevi, and choroidal naevi. ( 14693769 )
2004
47
Expression of PCNA and Ki-67 in posterior uveal melanomas in adults. ( 15638382 )
2004
48
Evidence of macrophage and lymphocyte, but not dendritic cell, infiltration in posterior uveal melanomas, whilst cultured uveal melanomas demonstrate pluripotency by expressing CD68 and CD163. ( 15113392 )
2004
49
Association between choroidal pigmentation and posterior uveal melanoma in a white population. ( 14693770 )
2004
50
Post-brachytherapy initial tumour regression rate correlates with metastatic spread in posterior uveal melanoma. ( 15205232 )
2004

Variations for Posterior Uveal Melanoma

Expression for Posterior Uveal Melanoma

Search GEO for disease gene expression data for Posterior Uveal Melanoma.

Pathways for Posterior Uveal Melanoma

GO Terms for Posterior Uveal Melanoma

Cellular components related to Posterior Uveal Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 MIR182 THBS1 THBS2 VEGFA
2 secretory granule GO:0030141 9.16 THBS1 VEGFA
3 platelet alpha granule lumen GO:0031093 8.96 THBS1 VEGFA
4 platelet alpha granule GO:0031091 8.62 THBS1 THBS2

Biological processes related to Posterior Uveal Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.54 CCND2 THBS1 VEGFA
2 platelet degranulation GO:0002576 9.43 THBS1 VEGFA
3 negative regulation of angiogenesis GO:0016525 9.4 THBS1 THBS2
4 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.32 THBS1 VEGFA
5 positive regulation of endothelial cell migration GO:0010595 9.26 THBS1 VEGFA
6 negative regulation of apoptotic process GO:0043066 9.26 CCND2 MITF THBS1 VEGFA
7 positive regulation of blood vessel endothelial cell migration GO:0043536 9.16 THBS1 VEGFA
8 regulation of cGMP metabolic process GO:0030823 8.62 THBS1 VEGFA

Molecular functions related to Posterior Uveal Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix binding GO:0050840 9.16 THBS1 VEGFA
2 fibronectin binding GO:0001968 8.96 THBS1 VEGFA
3 heparin binding GO:0008201 8.8 THBS1 THBS2 VEGFA

Sources for Posterior Uveal Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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