MCID: PST022
MIFTS: 45

Posterior Uveal Melanoma

Categories: Cancer diseases, Eye diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Posterior Uveal Melanoma

MalaCards integrated aliases for Posterior Uveal Melanoma:

Name: Posterior Uveal Melanoma 12 15
Ciliary Body and Choroid Melanoma, Medium/large Size 73
Ciliary Body and Choroid Melanoma, Small Size 73
Medium/large Size Posterior Uveal Melanoma 12
Small Size Posterior Uveal Melanoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6566
NCIt 50 C9089 C9090

Summaries for Posterior Uveal Melanoma

MalaCards based summary : Posterior Uveal Melanoma, also known as ciliary body and choroid melanoma, medium/large size, is related to melanoma, uveal and melanoma. An important gene associated with Posterior Uveal Melanoma is THBS2 (Thrombospondin 2), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Ras signaling pathway. The drugs Dacarbazine and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and eye, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Posterior Uveal Melanoma

Diseases in the Melanoma, Uveal family:

Melanoma, Uveal 1 Melanoma, Uveal 2
Posterior Uveal Melanoma

Diseases related to Posterior Uveal Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 melanoma, uveal 31.1 BRAF MITF THBS1
2 melanoma 11.0
3 intraocular melanoma 10.3
4 mucosal melanoma 10.0 BRAF MITF
5 retinal detachment 10.0
6 retinoblastoma 10.0
7 microphthalmia 10.0
8 macular holes 10.0
9 skin melanoma 10.0 BRAF MITF
10 colorectal adenocarcinoma 9.9 BRAF VEGFA
11 differentiated thyroid carcinoma 9.9 BRAF VEGFA
12 vascular cancer 9.9 THBS1 VEGFA
13 arteriovenous malformations of the brain 9.9 THBS1 VEGFA
14 corneal neovascularization 9.9 THBS1 VEGFA
15 renal cell carcinoma, papillary, 1 9.8 BRAF MITF
16 myeloma, multiple 9.8 BRAF CCND2 VEGFA
17 glioma 9.8 BRAF CCND2 VEGFA
18 brain cancer 9.7 BRAF THBS1 VEGFA

Graphical network of the top 20 diseases related to Posterior Uveal Melanoma:



Diseases related to Posterior Uveal Melanoma

Symptoms & Phenotypes for Posterior Uveal Melanoma

MGI Mouse Phenotypes related to Posterior Uveal Melanoma:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 BRAF CCND2 MITF THBS1 THBS2 VEGFA
2 homeostasis/metabolism MP:0005376 9.99 BRAF CCND2 MITF THBS1 THBS2 VEGFA
3 immune system MP:0005387 9.97 BRAF CCND2 MITF THBS1 THBS2 VEGFA
4 behavior/neurological MP:0005386 9.96 BRAF CCND2 MITF THBS2 VEGFA
5 cardiovascular system MP:0005385 9.95 BRAF CCND2 THBS1 THBS2 VEGFA
6 endocrine/exocrine gland MP:0005379 9.93 BRAF CCND2 MITF THBS1 VEGFA
7 integument MP:0010771 9.88 BRAF MITF THBS1 THBS2 VEGFA
8 mortality/aging MP:0010768 9.88 BRAF CCND2 MITF THBS1 THBS2 VEGFA
9 limbs/digits/tail MP:0005371 9.85 BRAF MITF THBS1 THBS2 VEGFA
10 liver/biliary system MP:0005370 9.73 BRAF CCND2 THBS1 VEGFA
11 muscle MP:0005369 9.67 BRAF THBS1 THBS2 VEGFA
12 reproductive system MP:0005389 9.65 BRAF CCND2 MITF THBS1 VEGFA
13 neoplasm MP:0002006 9.62 BRAF THBS1 THBS2 VEGFA
14 respiratory system MP:0005388 9.46 BRAF THBS1 THBS2 VEGFA
15 skeleton MP:0005390 9.35 BRAF MITF THBS1 THBS2 VEGFA
16 vision/eye MP:0005391 9.02 BRAF CCND2 MITF THBS1 VEGFA

Drugs & Therapeutics for Posterior Uveal Melanoma

Drugs for Posterior Uveal Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
2
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
3
Imidazole Experimental, Investigational Phase 2 288-32-4 795
4 Alkylating Agents Phase 2
5 Antineoplastic Agents, Alkylating Phase 2
6 Liver Extracts Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Temozolomide or Selumetinib in Treating Patients With Metastatic Melanoma of the Eye Completed NCT01143402 Phase 2 Dacarbazine;Selumetinib;Temozolomide
2 Radiation Therapy in Preventing Liver Metastases in Patients With Uveal Melanoma Who HaveMonosomy 3 or DecisionDx Class 2 Disease and Are More Likely to Develop Liver Metastases Terminated NCT02336763 Not Applicable
3 Validation of a Molecular Prognostic Test for Eye Melanoma Withdrawn NCT00406120

Search NIH Clinical Center for Posterior Uveal Melanoma

Genetic Tests for Posterior Uveal Melanoma

Anatomical Context for Posterior Uveal Melanoma

MalaCards organs/tissues related to Posterior Uveal Melanoma:

41
Liver, Bone, Eye, Endothelial, Bone Marrow, Thyroid, Brain

Publications for Posterior Uveal Melanoma

Articles related to Posterior Uveal Melanoma:

(show top 50) (show all 95)
# Title Authors Year
1
Plaque brachytherapy for posterior uveal melanoma in 2018: improved techniques and expanded indications. ( 29538180 )
2018
2
Unsuspected and misdiagnosed posterior uveal melanoma following enucleation and evisceration in Ottawa-Gatineau. ( 29631828 )
2018
3
Long-Term Metastatic Risk after Biopsy of Posterior Uveal Melanoma. ( 29705056 )
2018
4
Visual outcome after posterior uveal melanoma episcleral brachytherapy including radiobiological doses. ( 29789761 )
2018
5
Posterior uveal melanoma in adolescents and children: current perspectives. ( 30464381 )
2018
6
Clinical Features, Metastasis, and Survival in Patients Younger Than 21 Years With Posterior Uveal Melanoma. ( 30422230 )
2018
7
INTRAVITREAL DEXAMETHASONE (OZURDEX) IMPLANT FOR RADIATION MACULOPATHY SECONDARY TO STEREOTACTIC RADIOTHERAPY FOR POSTERIOR UVEAL MELANOMA. ( 28489707 )
2017
8
Local Failure After Episcleral Brachytherapy for Posterior Uveal Melanoma: Patterns, Risk Factors, and Management. ( 28163118 )
2017
9
Local Failure After Episcleral Brachytherapy for Posterior Uveal Melanoma: Patterns, Risk Factors, and Management. ( 28756956 )
2017
10
Repeat Episcleral Plaque Brachytherapy: Clinical Outcomes in Patients Treated for Locally Recurrent Posterior Uveal Melanoma. ( 28048976 )
2016
11
Clinical application of genetic testing for posterior uveal melanoma. ( 27847622 )
2016
12
Management of posterior uveal melanoma: past, present, and future: the 2014 Charles L. Schepens lecture. ( 25439609 )
2015
13
Sufficiency of FNAB aspirates of posterior uveal melanoma for cytologic versus GEP classification in 159 patients, and relative prognostic significance of these classifications. ( 24270974 )
2014
14
Relationship between rate of posterior uveal melanoma flattening following plaque radiotherapy and GEP class of tumor cells. ( 24408979 )
2014
15
Treatment of posterior uveal melanoma with multi-dose photodynamic therapy. ( 24463441 )
2014
16
Diffusion restriction of posterior uveal melanoma on MR imaging. ( 25597216 )
2014
17
Gamma-knife-based stereotactic radiosurgery for medium- and large-sized posterior uveal melanoma. ( 22944897 )
2013
18
Long-term followup comparing two treatment dosing strategies of (125) I plaque radiotherapy in the management of small/medium posterior uveal melanoma. ( 23533708 )
2013
19
American Joint Committee on Cancer classification of posterior uveal melanoma (tumor size category) predicts prognosis in 7731 patients. ( 23664467 )
2013
20
Genome-wide profiling is a clinically relevant and affordable prognostic test in posterior uveal melanoma. ( 24169649 )
2013
21
Intravitreal triamcinolone versus intravitreal bevacizumab in the treatment of exudative retinal detachment secondary to posterior uveal melanoma. ( 22995029 )
2013
22
Combination therapy with triamcinolone acetonide and bevacizumab for the treatment of severe radiation maculopathy in patients with posterior uveal melanoma. ( 24092966 )
2013
23
Tumor-related lipid exudation and associated tumor-related complications after plaque radiotherapy of posterior uveal melanoma. ( 23483500 )
2013
24
Posterior uveal melanoma coexistent with macular hole. ( 23604299 )
2013
25
One-day session LINAC-based stereotactic radiosurgery of posterior uveal melanoma. ( 21534252 )
2012
26
Evaluation of the surgical learning curve for I-125 episcleral plaque placement for the treatment of posterior uveal melanoma: a two decade review. ( 22536035 )
2012
27
Safety of pars plana vitrectomy in eyes with plaque-irradiated posterior uveal melanoma. ( 23044941 )
2012
28
Role of microRNA-182 in posterior uveal melanoma: regulation of tumor development through MITF, BCL2 and cyclin D2. ( 22848417 )
2012
29
Carcinoembryonic antigen cell adhesion molecule-1 (CEACAM1) in posterior uveal melanoma: correlation with clinical and histological survival markers. ( 22039239 )
2011
30
Posterior uveal melanoma in young patients treated with proton beam therapy. ( 20224468 )
2010
31
No differences in outcome between radical surgical treatment (enucleation) and stereotactic radiosurgery in patients with posterior uveal melanoma. ( 20429631 )
2010
32
Update on posterior uveal melanoma: treatment of the eye and emerging strategies in the prognosis and treatment of metastatic disease. ( 19644367 )
2009
33
A reappraisal of the significance of largest basal diameter of posterior uveal melanoma. ( 19876071 )
2009
34
The T1799A point mutation is present in posterior uveal melanoma. ( 18985043 )
2008
35
Posterior uveal melanoma. Distribution of the sites of origin and patterns of tumour extent in the ocular fundus. ( 18523080 )
2008
36
Posterior uveal melanoma treated with I-125 brachytherapy or primary enucleation. ( 17585309 )
2008
37
In vivo monosomy 3 detection of posterior uveal melanoma: 3-year follow-up. ( 17934749 )
2008
38
Lipid exudation following plaque radiotherapy for posterior uveal melanoma. ( 16490526 )
2006
39
Apoptosis inhibitor, survivin, in posterior uveal melanoma: comparison among primary tumors, tumors resistant to brachytherapy, tumors with liver metastases, and liver metastases. ( 16531282 )
2006
40
Proton or stereotactic photon irradiation for posterior uveal melanoma? A planning intercomparison. ( 16362788 )
2005
41
18 years' experience with high dose rate strontium-90 brachytherapy of small to medium sized posterior uveal melanoma. ( 16170122 )
2005
42
Genomic investigations of posterior uveal melanoma. ( 16352494 )
2005
43
Differential expression of angioregulatory matricellular proteins in posterior uveal melanoma. ( 16314734 )
2005
44
Association between posterior uveal melanoma and iris freckles, iris naevi, and choroidal naevi. ( 14693769 )
2004
45
Association between choroidal pigmentation and posterior uveal melanoma in a white population. ( 14693770 )
2004
46
Post-brachytherapy initial tumour regression rate correlates with metastatic spread in posterior uveal melanoma. ( 15205232 )
2004
47
Pars plana vitrectomy in eyes containing a treated posterior uveal melanoma. ( 12967800 )
2003
48
Noncontiguous tumor recurrence of posterior uveal melanoma after transscleral local resection. ( 12470139 )
2002
49
Management of posterior uveal melanoma: past, present, future. ( 11927844 )
2002
50
Changes in ultrasound findings in posterior uveal melanoma after Ruthenium 106 brachytherapy. ( 12045056 )
2002

Variations for Posterior Uveal Melanoma

Expression for Posterior Uveal Melanoma

Search GEO for disease gene expression data for Posterior Uveal Melanoma.

Pathways for Posterior Uveal Melanoma

Pathways related to Posterior Uveal Melanoma according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.51 CCND2 THBS1 THBS2 VEGFA
2
Show member pathways
12.34 BRAF THBS1 VEGFA
3 12.28 BRAF CCND2 MITF VEGFA
4
Show member pathways
12.13 BRAF CCND2 MITF VEGFA
5 12.11 CCND2 THBS1 VEGFA
6 11.88 BRAF THBS1 VEGFA
7
Show member pathways
11.86 BRAF MITF VEGFA
8
Show member pathways
11.79 BRAF CCND2 THBS1 THBS2 VEGFA
9 11.72 BRAF CCND2 VEGFA
10 11.58 BRAF THBS1
11 11.45 CCND2 MITF
12
Show member pathways
11.42 THBS1 THBS2
13 11.2 THBS1 THBS2
14 11.13 THBS1 THBS2
15 11.1 BRAF VEGFA
16 11 BRAF THBS1 VEGFA

GO Terms for Posterior Uveal Melanoma

Cellular components related to Posterior Uveal Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 9.26 THBS1 VEGFA
2 platelet alpha granule lumen GO:0031093 9.16 THBS1 VEGFA
3 extracellular matrix GO:0031012 9.13 THBS1 THBS2 VEGFA
4 platelet alpha granule GO:0031091 8.62 THBS1 THBS2

Biological processes related to Posterior Uveal Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.61 CCND2 THBS1 VEGFA
2 positive regulation of gene expression GO:0010628 9.5 BRAF MITF VEGFA
3 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.4 BRAF VEGFA
4 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.37 THBS1 VEGFA
5 positive regulation of endothelial cell migration GO:0010595 9.26 THBS1 VEGFA
6 positive regulation of blood vessel endothelial cell migration GO:0043536 9.16 THBS1 VEGFA
7 negative regulation of apoptotic process GO:0043066 9.02 BRAF CCND2 MITF THBS1 VEGFA
8 sprouting angiogenesis GO:0002040 8.96 THBS1 VEGFA

Molecular functions related to Posterior Uveal Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix binding GO:0050840 9.16 THBS1 VEGFA
2 fibronectin binding GO:0001968 8.96 THBS1 VEGFA
3 heparin binding GO:0008201 8.8 THBS1 THBS2 VEGFA

Sources for Posterior Uveal Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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