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MCID: PST005
MIFTS: 52

Posterior Uveitis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Posterior Uveitis

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MalaCards integrated aliases for Posterior Uveitis:

Name: Posterior Uveitis 12 76 53 15
Uveitis, Posterior 12 76 44 73
Uveitis Posterior 55

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases Neuronal diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12574
MeSH 44 D015866
NCIt 50 C35111
SNOMED-CT 68 43363007 46627006
UMLS 73 C0042167
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Summaries for Posterior Uveitis

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MalaCards based summary : Posterior Uveitis, also known as uveitis, posterior, is related to chorioretinitis and choroiditis, and has symptoms including eye manifestations An important gene associated with Posterior Uveitis is SAG (S-Antigen Visual Arrestin), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. The drugs Fluocinolone Acetonide and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotypes are immune system and mortality/aging

Wikipedia : 76 Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the... more...

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Related Diseases for Posterior Uveitis

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Diseases in the Uveitis family:

Autoimmune Uveitis Posterior Uveitis
Intermediate Uveitis Infectious Anterior Uveitis
Anterior Uveitis Infectious Posterior Uveitis

Diseases related to Posterior Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 257)
# Related Disease Score Top Affiliating Genes
1 chorioretinitis 32.3 RBP3 SAG
2 choroiditis 32.2 CFH TNF
3 uveitis 30.9 CAPN5 IFNG IL2RA RBP3 SAG TNF
4 panuveitis 30.6 RBP3 SAG TNF
5 intermediate uveitis 30.0 IFNG IL2 IL2RA IL6 TNF
6 scleritis 29.9 IFNG TNF
7 macular retinal edema 29.9 CAPN5 IL6
8 viral infectious disease 29.7 IFNG IL2 IL6 TNF
9 toxoplasmosis 29.7 IFNG IL6 TNF
10 measles 29.6 IFNG IL2 IL6
11 mumps 29.5 IFNG IL2 IL2RA TNF
12 multiple sclerosis 29.4 IFNG IL2 IL2RA IL6 TNF
13 autoimmune uveitis 29.3 CAPN5 IFNG IL2 RBP3 SAG TNF
14 acquired immunodeficiency syndrome 29.2 IFNG IL2 IL2RA IL6 TNF
15 anterior uveitis 29.2 CFH IL2RA IL6 TNF
16 autoimmune disease 28.7 IFNG IL2 IL2RA IL6 RBP3 SAG
17 infectious posterior uveitis 12.3
18 idiopathic posterior uveitis 12.3
19 birdshot chorioretinopathy 11.3
20 vitreoretinopathy, neovascular inflammatory 11.1
21 retinal vasculitis 11.1
22 primary systemic mycosis 10.3 IFNG TNF
23 cytomegalovirus retinitis 10.3 IFNG TNF
24 pleural tuberculosis 10.3 IFNG TNF
25 spotted fever 10.3 IFNG TNF
26 aseptic meningitis 10.3 IFNG TNF
27 poliomyelitis 10.3 IFNG TNF
28 lichen disease 10.3 IFNG TNF
29 orofacial granulomatosis 10.3 IFNG TNF
30 oligoarticular juvenile idiopathic arthritis 10.2 IL2RA TNF
31 folliculitis 10.2 IFNG IL2RA
32 toxic oil syndrome 10.2 IFNG IL2RA
33 progressive multifocal leukoencephalopathy 10.2 IL2 TNF
34 staphylococcal toxic shock syndrome 10.2 IFNG TNF
35 autoimmune myocarditis 10.2 IFNG TNF
36 ischemic heart disease 10.2 IL6 TNF
37 joint disorders 10.2 IL6 TNF
38 post-transplant lymphoproliferative disease 10.2 IL6 TNF
39 trichosporonosis 10.2 IFNG TNF
40 endometritis 10.2 IL6 TNF
41 pulpitis 10.2 IL6 TNF
42 listeriosis 10.2 IL6 TNF
43 crimean-congo hemorrhagic fever 10.2 IL6 TNF
44 periventricular leukomalacia 10.2 IL6 TNF
45 hypersensitivity reaction type iii disease 10.2 IL6 TNF
46 chronic beryllium disease 10.2 IFNG TNF
47 spinal cord disease 10.2 IL6 TNF
48 middle ear disease 10.2 IL6 TNF
49 monoclonal gammopathy of uncertain significance 10.2 IL6 TNF
50 localized scleroderma 10.2 IL6 TNF

Graphical network of the top 20 diseases related to Posterior Uveitis:



Diseases related to Posterior Uveitis
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Symptoms & Phenotypes for Posterior Uveitis

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UMLS symptoms related to Posterior Uveitis:


eye manifestations

MGI Mouse Phenotypes related to Posterior Uveitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.7 CAPN5 CFH IFNG IL2 IL2RA IL6
2 mortality/aging MP:0010768 9.56 CAPN5 CFH IFNG IL2 IL2RA IL6
3 vision/eye MP:0005391 9.28 CFH IFNG IL2 IL2RA IL6 KIAA1109
Sources

Drugs & Therapeutics for Posterior Uveitis

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Drugs for Posterior Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 88)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 67-73-2 6215
2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-24-8 5755
4
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 302-25-0
5
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Not Applicable 2921-57-5
6
Mycophenolic acid Approved Phase 4 24280-93-1 446541
7
Azathioprine Approved Phase 4,Phase 2 446-86-6 2265
8
Methotrexate Approved Phase 4,Phase 2,Phase 1,Not Applicable 59-05-2, 1959-05-2 126941
9
Infliximab Approved Phase 4,Phase 1,Phase 2 170277-31-3
10
leucovorin Approved Phase 4,Phase 1,Phase 2,Not Applicable 58-05-9 6006 143
11
Chlorambucil Approved Phase 4 305-03-3 2708
12
Cyclophosphamide Approved, Investigational Phase 4,Phase 2 6055-19-2, 50-18-0 2907
13
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
14
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
15
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-02-2 5743
16
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 1177-87-3
17
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 124-94-7 31307
18
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 59-30-3 6037
19
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2,Not Applicable 2920-86-7
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
21 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
22 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
23 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
24 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
25 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
26 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
27 Prednisolone acetate Phase 4,Phase 3,Phase 2,Not Applicable
28 Neuroprotective Agents Phase 4,Not Applicable
29 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
30 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
31 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
32 Protective Agents Phase 4,Not Applicable
33 Methylprednisolone acetate Phase 4,Phase 3,Phase 2,Not Applicable
34 Antimetabolites Phase 4,Phase 1,Phase 2,Not Applicable
35 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 1
36 Anti-Bacterial Agents Phase 4,Phase 2,Phase 1
37 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Cyclosporins Phase 4,Phase 3
39 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Antitubercular Agents Phase 4
41 Antimetabolites, Antineoplastic Phase 4,Phase 1,Phase 2,Not Applicable
42 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
44 Vitamin B Complex Phase 4,Phase 1,Phase 2,Not Applicable
45 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 1,Phase 2,Not Applicable
46 Folic Acid Antagonists Phase 4,Phase 1,Phase 2,Not Applicable
47 Dermatologic Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
48 Folate Phase 4,Phase 1,Phase 2,Not Applicable
49 Vitamin B9 Phase 4,Phase 1,Phase 2,Not Applicable
50 Antineoplastic Agents, Alkylating Phase 4

Interventional clinical trials:

(show top 50) (show all 62)
# Name Status NCT ID Phase Drugs
1 Flucinolone Acetonide Implant for Treating Refractory Ocular Behcet's Disease Unknown status NCT00720928 Phase 4 flucinolone acetonide
2 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4 methylorednisolone
3 Multicenter Uveitis Steroid Treatment (MUST) Trial Completed NCT00132691 Phase 4 fluocinolone acetonide intraocular implant;oral corticosteroid with immunosuppressive agents as needed
4 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
5 Efficacy and Safety of H.P. Acthar® Gel in Subjects With Severe Noninfectious Intermediate Uveitis, Posterior Uveitis, or Panuveitis NIPPU Recruiting NCT03656692 Phase 4 Acthar
6 Study of the Effectiveness of Ozurdex for the Control of Uveitis Recruiting NCT02049476 Phase 4 Dexamethasone pellet
7 Efficacy Study of Methotrexate to Treat Sarcoid-associated Uveitis Terminated NCT00918554 Phase 4 Methotrexate;Placebo
8 A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Intermediate or Posterior Uveitis Completed NCT00333814 Phase 2, Phase 3 Dexamethasone;dexamethasone;Sham injection
9 Efficacy and Safety of Adalimumab in Subjects With Inactive Uveitis Completed NCT01124838 Phase 3 Adalimumab;Prednisone;Placebo
10 Safety and Efficacy of Fluocinolone Acetonide Intravitreal Implants Completed NCT00407082 Phase 2, Phase 3 fluocinolone acetonide intravitreal implant;Fluocinolone acetonide 2.1mg
11 Efficacy and Safety of Adalimumab in Patients With Active Uveitis Completed NCT01138657 Phase 3 Prednisone;Placebo
12 Phase III Study in Refractory Behcet's Disease Completed NCT00995709 Phase 3 AIN457;AIN457;Placebo
13 A Controlled, Multi-center Study of the Utilization and Safety of the MK II Inserter and the Safety of the FAI Insert in Subjects With Non-infectious Uveitis Affecting the Posterior Segment of the Eye Completed NCT02748512 Phase 3 FAI insert
14 Interferon-alpha2a Versus Cyclosporin A for Severe Ocular Behcet`s Disease (INCYTOB) Completed NCT00167583 Phase 3 Cyclosporin A;Interferon-alpha2a
15 A Study of the Long-term Safety and Efficacy of Adalimumab in Subjects With Intermediate-, Posterior-, or Pan-uveitis Completed NCT01148225 Phase 3 adalimumab
16 Suprachoroidal Injection of CLS-TA in Subjects Non-infectious Uveitis Completed NCT03097315 Phase 3
17 Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis Completed NCT02595398 Phase 3 4mg CLS-TA Suprachoriodal Injection;Sham Procedure
18 Safety and Efficacy Study of a Fluocinolone Acetonide Intravitreal (FAI) Insert in Subjects With Chronic Non-infectious Posterior Uveitis Active, not recruiting NCT02746991 Phase 3 Sham Injection;FAI Insert
19 Safety and Efficacy of an Injectable Fluocinolone Acetonide Intravitreal Insert Active, not recruiting NCT01694186 Phase 3 FAI insert;Sham injection
20 38 Week Extension Study to CAIN457C2303 Terminated NCT01093846 Phase 3 AIN457;AIN457;Placebo AIN457
21 Safety and Efficacy of AIN457 in Patients With Active Non-infectious Uveitis Terminated NCT01095250 Phase 3 AIN457;AIN457;AIN457;Placebo
22 Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis Terminated NCT01032915 Phase 3 Placebo
23 Long-term Safety of Gevokizumab in the Treatment of Patients With Chronic Non-infectious Uveitis (EYEGUARD-X) Terminated NCT02375685 Phase 3
24 Safety and Efficacy Study of Gevokizumab to Treat Non-infectious Uveitis Controlled With Systemic Treatment Terminated NCT01747538 Phase 3 Placebo;Dose 1 gevokizumab;Dose 2 gevokizumab
25 Safety and Efficacy Study of Gevokizumab to Treat Active Non-infectious Uveitis Terminated NCT01684345 Phase 3 Placebo;Dose 1 gevokizumab;Dose 2 gevokizumab
26 Extension Study to Assess Safety and Efficacy of AIN457 in Patients With Active Non-infectious Uveitis Terminated NCT01103024 Phase 3
27 An Open-label, Rollover Study Providing Continued Dosing of Gevokizumab in Order to Assess Long-term Gevokizumab Safety Data Terminated NCT02258854 Phase 3 Dose 2 gevokizumab
28 Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis Terminated NCT01090310 Phase 3 AIN457;Placebo
29 Study to Evaluate the Long Term Use of Treatment With AIN457 for Uveitis Withdrawn NCT01327664 Phase 3
30 Combination Daclizumab/Denileukin Diftitox to Treat Uveitis Completed NCT00326508 Phase 2 Daclizumab
31 Safety, Tolerability, and Efficacy of AEB071 in the Treatment of Uveitis Completed NCT00615693 Phase 2 AEB071
32 Safety,Tolerability and Efficacy of Intravitreal LFG316 in Patients With Active Non-infectious Intermediate-, posterior-or Panuveitis , Completed NCT01526889 Phase 2 LFG316;Conventional Therapy
33 Evaluation of Birdshot Retine Choroidopathy Treatment by Either Steroid or Interferon alpha2a Completed NCT00508040 Phase 2 interferon alpha 2a;prednisone
34 Daclizumab to Treat Non-Infectious Sight-Threatening Uveitis Completed NCT00070759 Phase 2 Daclizumab
35 Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat Uveitis Completed NCT01789320 Phase 1, Phase 2 triamcinolone acetonide (Triesence®)
36 Rituximab for the Treatment of Severe Ocular Manifestations of Behcet's Disease Completed NCT00664599 Phase 2 Rituximab;Cytotoxic Combination
37 Intravitreal Infliximab in Refractory Uveitis in Behcet's Disease: A Safety and Efficacy Clinical Study Completed NCT02620618 Phase 1, Phase 2 Intravitreal Infliximab
38 Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis Completed NCT02255032 Phase 2 4 mg CLS-TA;0.8 mg CLS-TA
39 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2 AIN457;AIN 457;AIN457
40 Efficacy and Safety of Ustekinumab, a Human Monoclonal Anti-IL-12/IL-23 Antibody, in Patients With Behçet Disease Recruiting NCT02648581 Phase 2 Subcutaneous Ustekinumab
41 Intravitreal Sirolimus as Therapeutic Approach to Uveitis Recruiting NCT01280669 Phase 2 Intravitreal injection 440mcg;Intravitreal injection of sirolimus 880mcg
42 ACTH as A Re-emerging theRapy for Uveitis (The ACTHAR Study) Recruiting NCT02931175 Phase 2 ACTH gel
43 Study of the Safety, Tolerability, and Bioactivity of Tocilizumab On Patients With Non-infectious UVEITIS: The STOP-UVEITIS Study Active, not recruiting NCT01717170 Phase 1, Phase 2 Tocilizumab
44 Treatment of Non-infectious Intermediate and Posterior Uveitis Associated Macular Edema With Intravitreal Methotrexate Terminated NCT01314417 Phase 1, Phase 2 Methotrexate
45 Safety &Efficacy of CF101 to Subjects With Uveitis Withdrawn NCT01905124 Phase 2 CF101;Placebo
46 A Phase I/IIa Study for the Treatment of Uveitis With Iontophoresis Withdrawn NCT00499551 Phase 1, Phase 2
47 Efalizumab to Treat Uveitis Completed NCT00280826 Phase 1 Efalizumab
48 ANTI-TAC THERAPY FOR UVEITIS Completed NCT00001526 Phase 1 Daclizumab (Zenapax)
49 Daclizumab and Sirolimus to Treat Uveitis Completed NCT00078689 Phase 1 Daclizumab
50 Prophylactic Anecortave Acetate in Patients With a Retisert Implant Completed NCT00570479 Phase 1 anecortave acetate

Search NIH Clinical Center for Posterior Uveitis

Cochrane evidence based reviews: uveitis, posterior

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Genetic Tests for Posterior Uveitis

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Anatomical Context for Posterior Uveitis

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MalaCards organs/tissues related to Posterior Uveitis:

41
Eye, Retina, Endothelial, T Cells, Lung, Heart, B Cells
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Publications for Posterior Uveitis

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Articles related to Posterior Uveitis:

(show top 50) (show all 227)
# Title Authors Year
1
DETECTION OF TYPE 1 CHOROIDAL NEOVASCULAR MEMBRANES USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN TUBERCULAR POSTERIOR UVEITIS. ( 29689028 )
2018
2
Superficial and deep retinal foveal avascular zone OCTA findings of non-infectious anterior and posterior uveitis. ( 29980918 )
2018
3
Need for Quantitative Measurement Methods for Posterior Uveitis: Comparison of Dual FA/ICGA Angiography, EDI-OCT Choroidal Thickness and SUN Vitreous Haze Evaluation in Stromal Choroiditis. ( 29669371 )
2018
4
Inner Retinal Microvasculature Damage Correlates With Outer Retinal Disruption During Remission in BehAset's Posterior Uveitis by Optical Coherence Tomography Angiography. ( 29625452 )
2018
5
Bilateral ipilimumab-induced posterior uveitis following treatment for metastatic choroidal melanoma. ( 29653019 )
2018
6
Comparative efficacy between adalimumab and infliximab in the treatment of non-infectious intermediate uveitis, posterior uveitis, and panuveitis: a retrospective observational study of 107 patients. ( 30099655 )
2018
7
COMBINED VITRECTOMY WITH INTRAVITREAL DEXAMETHASONE IMPLANT FOR REFRACTORY MACULAR EDEMA SECONDARY TO DIABETIC RETINOPATHY, RETINAL VEIN OCCLUSION, AND NONINFECTIOUS POSTERIOR UVEITIS. ( 30312262 )
2018
8
Morphometric features on enhanced depth imaging optical coherence tomography scans in idiopathic posterior uveitis or panuveitis. ( 28585111 )
2017
9
Vogt-Koyanagi-Harada disease-like posterior uveitis in the course of nivolumab (anti-PD-1 antibody), interposed by vemurafenib (BRAF inhibitor), for metastatic cutaneous malignant melanoma. ( 28469878 )
2017
10
The Effectiveness of Pre- and Postoperative Infliximab in Controlling BehAset's Disease Posterior Uveitis in Patients Undergoing Vitrectomy: A Preliminary Study. ( 28484648 )
2017
11
A systematic review and economic evaluation of adalimumab and dexamethasone for treating non-infectious intermediate uveitis, posterior uveitis or panuveitis in adults. ( 29183563 )
2017
12
Reply to Lee and colleagues-Viral posterior uveitis. ( 28624250 )
2017
13
Re: Jaffe etA al.: Injectable fluocinolone acetonide long-acting implant for noninfectious intermediate uveitis, posterior uveitis, and panuveitis: 2-year results (Ophthalmology. 2016;123:1940-1948). ( 28734339 )
2017
14
Bilateral posterior uveitis associated with Zika virus infection. ( 27939402 )
2017
15
Re: Jaffe etA al.: Injectable fluocinolone acetonide long-acting implant for noninfectious intermediate uveitis, posterior uveitis, and panuveitis: two-year results (Ophthalmology. 2016;123:1940-1948). ( 28335961 )
2017
16
LONG-TERM OUTCOMES OF RITUXIMAB THERAPY IN PATIENTS WITH NONINFECTIOUS POSTERIOR UVEITIS REFRACTORY TO CONVENTIONAL IMMUNOSUPPRESSIVE THERAPY. ( 28225369 )
2017
17
Stalagmite-like preretinal inflammatory deposits in vitrectomized eyes with posterior uveitis. ( 28924415 )
2017
18
Viral Posterior Uveitis-Author's reply. ( 28606632 )
2017
19
Long-term Change of Subfoveal Choroidal Thickness in BehAset's Disease Patients with Posterior Uveitis. ( 28080153 )
2017
20
Effect of Adalimumab on Visual Functioning in Patients With Noninfectious Intermediate Uveitis, Posterior Uveitis, and Panuveitis in the VISUAL-1 and VISUAL-2 Trials. ( 28426849 )
2017
21
Detection of mild papilloedema in posterior uveitis using spectral domain optical coherence tomography. ( 27872047 )
2017
22
Dexamethasone implants in paediatric patients with noninfectious intermediate or posterior uveitis: first prospective exploratory case series. ( 29246154 )
2017
23
PEMBROLIZUMAB ADMINISTRATION ASSOCIATED WITH POSTERIOR UVEITIS. ( 27490976 )
2016
24
Risk of Ocular Complications in Patients with Noninfectious Intermediate Uveitis, Posterior Uveitis, or Panuveitis. ( 26712559 )
2016
25
Management of noninfectious posterior uveitis with intravitreal drug therapy. ( 27789936 )
2016
26
Viral Posterior Uveitis. ( 28012878 )
2016
27
The association between the parenchymal neurological involvement and posterior uveitis in BehAset's syndrome. ( 27791948 )
2016
28
Posterior Uveitis. ( 26502276 )
2016
29
The Effectiveness of Intraocular Methotrexate in the Treatment of Posterior Uveitis in BehAset's Disease Patients Compared to Retrobulbar Steroids Injection. ( 28070412 )
2016
30
A case of unilateral and spontaneously resolving posterior uveitis with overlapping features of Vogt-Koyanagi-Harada disease and Acute Posterior Multifocal Placoid Pigment Epitheliopathy. ( 27652046 )
2016
31
DELINEATION OF CHOROIDAL AND RETINAL LESIONS IN POSTERIOR UVEITIS BY MULTISPECTRAL WIDE-FIELD SCANNING LASER OPHTHALMOSCOPY. ( 27152831 )
2016
32
Failure to Integrate Quantitative Measurement Methods of Ocular Inflammation Hampers Clinical Practice and Trials on New Therapies for Posterior Uveitis. ( 27937751 )
2016
33
In-vivo immunofluorescent imaging in cases of posterior uveitis. ( 27063084 )
2016
34
Role of Ultra-Wide Field Imaging in the Management of Tubercular Posterior Uveitis. ( 26735848 )
2016
35
Injectable Fluocinolone Acetonide Long-Acting Implant for Noninfectious Intermediate Uveitis, Posterior Uveitis, and Panuveitis: Two-Year Results. ( 27421623 )
2016
36
Parafoveal cone abnormalities and recovery on adaptive optics in posterior uveitis. ( 29503883 )
2016
37
PRESUMED POSTERIOR UVEITIS RELATED TO EHRLICHIA EXPOSURE. ( 26352324 )
2015
38
Benefits of Systemic Anti-inflammatory Therapy versus Fluocinolone Acetonide Intraocular Implant for Intermediate Uveitis, Posterior Uveitis, and Panuveitis: Fifty-four-Month Results of the Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study. ( 26298715 )
2015
39
The Great Imitator: Ocular Syphilis Presenting as Posterior Uveitis. ( 26151369 )
2015
40
Syphilitic posterior uveitis. ( 25856651 )
2015
41
The role of fundus autofluorescence imaging in the study of the course of posterior uveitis disorders. ( 25695054 )
2015
42
Central Serous Chorioretinopathy Misdiagnosed as Posterior Uveitis and the Vicious Circle of Corticosteroid Therapy. ( 26730317 )
2015
43
Reply to Hall J: "Use of the Fluocinolone Acetonide Intravitreal Implant for the Treatment of Noninfectious Posterior Uveitis: 3-Year Results of a Randomized Clinical Trial in a Predominantly Asian Population" : Virender S. Sangwan, P. Andrew Pearson, Hemanth Paul, Timothy L. Comstock. ( 25794551 )
2015
44
Comment on: "Use of the Fluocinolone Acetonide Intravitreal Implant for the Treatment of Noninfectious Posterior Uveitis: 3-Year Results of a Randomized Clinical Trial in a Predominantly Asian Population". ( 25786593 )
2015
45
Quality of Life and Risks Associated with Systemic Anti-inflammatory Therapy versus Fluocinolone Acetonide Intraocular Implant for Intermediate Uveitis, Posterior Uveitis, or Panuveitis: Fifty-four-Month Results of the Multicenter Uveitis Steroid Treatment Trial and Follow-up Study. ( 26298718 )
2015
46
Efficacy and tolerability of bilateral sustained-release dexamethasone intravitreal implants for the treatment of noninfectious posterior uveitis and macular edema secondary to retinal vein occlusion. ( 26150689 )
2015
47
Results of intravitreal dexamethasone implant 0.7 mg (OzurdexAr) in non-infectious posterior uveitis. ( 26309888 )
2015
48
Factors affecting therapeutic decisions in intermediate and posterior uveitis. ( 25449000 )
2015
49
Development and Evaluation of Dexamethasone Nanomicelles with Potential for Treating Posterior Uveitis After Topical Application. ( 25839185 )
2015
50
Intravitreal Dexamethasone Implant for Treatment of Refractory BehAset Posterior Uveitis: One-year Follow-up Results. ( 26470764 )
2015
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Variations for Posterior Uveitis

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Expression for Posterior Uveitis

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Search GEO for disease gene expression data for Posterior Uveitis.
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Pathways for Posterior Uveitis

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Pathways related to Posterior Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 66
Show member pathways
 13.22 IFNG IL2 IL2RA IL6 TNF
2
Allograft rejection 1 37
Show member pathways
 12.76 IFNG IL2 IL2RA IL6 TNF
3
Pathways in cancer 37
12.72 IFNG IL2 IL2RA IL6
4
Influenza A 37
Show member pathways
 12.67 IFNG IL2 IL2RA IL6 TNF
5
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways 65
Show member pathways
 12.66 IL2 IL2RA IL6 TNF
6
Immune response NFAT in immune response 22
Show member pathways
 12.53 IFNG IL2 IL2RA TNF
7
Immune response IL-23 signaling pathway 22
Show member pathways
 12.49 IFNG IL2 IL6 TNF
8
NF-kappaB Signaling 4
12.47 IFNG IL2 IL2RA TNF
9
Th17 cell differentiation 37
Show member pathways
 12.45 IFNG IL2 IL2RA IL6 TNF
10
T cell receptor signaling pathway 37
Show member pathways
 12.34 IFNG IL2 IL6 TNF
11
Human T-cell leukemia virus 1 infection 37
12.34 IL2 IL2RA IL6 TNF
12
JAK-STAT signaling pathway (KEGG) 37
Show member pathways
 12.3 IFNG IL2 IL2RA IL6
13
Selenium Micronutrient Network 1
Show member pathways
 12.25 IFNG IL2 IL6 TNF
14
IL-17 Family Signaling Pathways 65
Show member pathways
 12.22 IFNG IL6 TNF
15
Tuberculosis 37
12.13 IFNG IL6 TNF
16
C-type lectin receptor signaling pathway 37
Show member pathways
 12.11 IL2 IL6 TNF
17
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.1 IFNG IL2 IL2RA IL6 TNF
18
Bacterial infections in CF airways 22
Show member pathways
 12.08 IFNG IL6 TNF
19
Colorectal Cancer Metastasis 64
12.08 IFNG IL6 TNF
20
IL-2 Signaling Pathway 1
Show member pathways
 11.98 IFNG IL2 IL2RA
21
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.98 IFNG IL2 IL2RA IL6
22
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 11.95 IFNG IL6 TNF
23
Th1 Differentiation Pathway 65
Show member pathways
 11.95 IFNG IL2 IL6 TNF
24
IL12-mediated signaling events 1
Show member pathways
 11.9 IFNG IL2 IL2RA
25
Spinal Cord Injury 1
11.86 IFNG IL2 IL6 TNF
26
Hematopoietic cell lineage 37
11.83 IL2RA IL6 TNF
27
Amoebiasis 37
11.82 IFNG IL6 TNF
28
Rheumatoid arthritis 37
11.78 IFNG IL6 TNF
29
Jak-Stat Signaling Pathway (sino) 67
11.77 IFNG IL2 IL2RA IL6
30
Glucocorticoid receptor regulatory network 1
11.73 IFNG IL2 IL6
31
Innate Lymphoid Cell Differentiation Pathways 65
11.66 IFNG IL2 IL2RA TNF
32
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.61 IFNG IL2 IL2RA TNF
33
Dendritic Cells Developmental Lineage Pathway 65
11.57 IFNG IL2 IL6 TNF
34
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.52 IFNG IL2 IL6 TNF
35
Malaria 37
11.48 IFNG IL6 TNF
36
Aryl Hydrocarbon Receptor Pathway 1
11.46 IFNG IL2 TNF
37
Th2 Differentiation Pathway 65
11.44 IFNG IL2 IL2RA
38
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.42 IFNG IL6 TNF
39
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.42 IFNG IL2 IL6 TNF
40
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.42 IFNG IL2 IL2RA IL6 TNF
41
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.34 IFNG IL2 IL2RA TNF
42
African trypanosomiasis 37
11.3 IFNG IL6 TNF
43
IL-10 Pathway 64
11.26 IL6 TNF
44
Inflammatory Response Pathway 1
11.26 IFNG IL2 IL2RA
45
Development and heterogeneity of the ILC family 1
11.24 IFNG IL6 TNF
46
Antifolate resistance 37
11.2 IL6 TNF
47
Immune response_IL-12 signaling pathway 22
Show member pathways
 11.17 IFNG IL2RA
48
IL12 signaling mediated by STAT4 1
11.17 IFNG IL2 IL2RA
49
Photodynamic therapy-induced AP-1 survival signaling. 1
11.16 IFNG IL2 IL6 TNF
50
OX40 Pathway 64
11.12 IFNG IL2
Sources

GO Terms for Posterior Uveitis

About this section

Cellular components related to Posterior Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 CFH IFNG IL2 IL6 RBP3 TNF

Biological processes related to Posterior Uveitis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.86 IFNG IL2 IL6 TNF
2 MAPK cascade GO:0000165 9.8 IL2 IL2RA TNF
3 cytokine-mediated signaling pathway GO:0019221 9.8 IL2 IL2RA IL6 TNF
4 positive regulation of protein phosphorylation GO:0001934 9.78 IFNG IL2 TNF
5 immune response GO:0006955 9.72 IFNG IL2 IL2RA IL6 TNF
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 IFNG IL2 IL6
7 positive regulation of activated T cell proliferation GO:0042104 9.62 IL2 IL2RA
8 negative regulation of neurogenesis GO:0050768 9.62 IL6 TNF
9 positive regulation of protein complex assembly GO:0031334 9.61 IFNG TNF
10 protein import into nucleus, translocation GO:0000060 9.6 IFNG TNF
11 positive regulation of osteoclast differentiation GO:0045672 9.59 IFNG TNF
12 positive regulation of chemokine production GO:0032722 9.58 IL6 TNF
13 positive regulation of T cell differentiation GO:0045582 9.58 IL2 IL2RA
14 positive regulation of T cell proliferation GO:0042102 9.58 IL2 IL2RA IL6
15 positive regulation of glial cell proliferation GO:0060252 9.57 IL6 TNF
16 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.55 IFNG TNF
17 positive regulation of immunoglobulin secretion GO:0051024 9.54 IL2 IL6
18 humoral immune response GO:0006959 9.54 IFNG IL6 TNF
19 interleukin-2-mediated signaling pathway GO:0038110 9.52 IL2 IL2RA
20 negative regulation of lipid storage GO:0010888 9.51 IL6 TNF
21 negative regulation of lymphocyte proliferation GO:0050672 9.46 IL2 IL2RA
22 positive regulation of neuroinflammatory response GO:0150078 9.43 IL6 TNF
23 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 IFNG TNF
24 regulation of T cell homeostatic proliferation GO:0046013 9.16 IL2 IL2RA
25 positive regulation of vitamin D biosynthetic process GO:0060557 8.96 IFNG TNF
26 regulation of regulatory T cell differentiation GO:0045589 8.8 IFNG IL2 IL2RA

Molecular functions related to Posterior Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 IFNG IL2 IL6 TNF
Sources

Sources for Posterior Uveitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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