MCID: PST035
MIFTS: 34

Postgastrectomy Syndrome

Categories: Gastrointestinal diseases

Aliases & Classifications for Postgastrectomy Syndrome

MalaCards integrated aliases for Postgastrectomy Syndrome:

Name: Postgastrectomy Syndrome 12 15
Postgastrectomy Syndromes 44 73
Postgastric Surgery Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8439
ICD10 33 K91.1
ICD9CM 35 564.2
MeSH 44 D011178
SNOMED-CT 68 80193009
UMLS 73 C0032763

Summaries for Postgastrectomy Syndrome

MalaCards based summary : Postgastrectomy Syndrome, also known as postgastrectomy syndromes, is related to dumping syndrome and pancreatoblastoma, and has symptoms including constipation, pain, postoperative and postoperative nausea and vomiting. An important gene associated with Postgastrectomy Syndrome is SST (Somatostatin), and among its related pathways/superpathways is Signaling by GPCR. The drugs Somatostatin and lanreotide have been mentioned in the context of this disorder. Affiliated tissues include testes, pituitary and pancreas, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Postgastrectomy Syndrome

Diseases related to Postgastrectomy Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 dumping syndrome 31.3 GIP INS NTS PYY SST
2 pancreatoblastoma 10.2 NTS SST
3 zollinger-ellison syndrome 10.1 NTS SST
4 wdha syndrome 10.1 SST VIP
5 duodenal somatostatinoma 10.1 INS SST
6 postural hypotension 10.1 INS SST
7 pancreatic endocrine carcinoma 10.1 INS SST
8 glucagonoma 10.1 SST VIP
9 insulinomatosis and diabetes mellitus 10.1 INS SST
10 insulinoma 10.1 INS SST
11 hyperpituitarism 10.1 INS SST
12 binswanger's disease 10.1 SST VIP
13 functional gastric disease 10.1 INS SST
14 cryptosporidiosis 10.1 SST VIP
15 pancreatic cystadenoma 10.1 INS SST
16 gastrointestinal system benign neoplasm 10.1 INS SST
17 pituitary-dependent cushing's disease 10.1 INS SST
18 endocrine organ benign neoplasm 10.1 INS SST
19 thyroid gland disease 10.1 INS SST
20 pituitary gland disease 10.1 INS SST
21 space motion sickness 10.1 NTS VIP
22 hyperinsulinemic hypoglycemia 10.1 INS SST
23 hyperprolactinemia 10.1 SST VIP
24 duodenal ulcer 10.1 INS SST
25 autonomic nervous system neoplasm 10.1 NTS VIP
26 cell type benign neoplasm 10.1 INS SST
27 peripheral nervous system neoplasm 10.1 NTS VIP
28 gallbladder disease 10.1 INS SST
29 acromegaly 10.0 INS SST
30 gastric cancer 10.0
31 hyperthyroidism 10.0 INS SST
32 microvascular complications of diabetes 1 10.0 INS SST
33 pertussis 10.0 SST VIP
34 pneumatosis cystoides intestinalis 10.0 PYY SST
35 insulin-like growth factor i 10.0 INS SST
36 serotonin syndrome 10.0 PYY SST
37 vipoma 10.0 NTS SST VIP
38 neuroendocrine tumor 10.0 NTS SST
39 endocrine gland cancer 10.0 SST VIP
40 somatostatinoma 9.9 INS SST VIP
41 gastrinoma 9.9 INS SST VIP
42 islet cell tumor 9.9 INS SST VIP
43 multiple endocrine neoplasia, type i 9.9 INS SST VIP
44 pancreatic cholera 9.9 GIP SST VIP
45 endocrine pancreas disease 9.9 GIP INS SST
46 pancreas disease 9.9 GIP INS SST
47 irritable bowel syndrome 9.9 PYY VIP
48 glucose metabolism disease 9.9 GIP INS SST
49 acquired metabolic disease 9.9 GIP INS SST
50 hyperglycemia 9.9 GIP INS SST

Comorbidity relations with Postgastrectomy Syndrome via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Esophagitis Intestinal Obstruction
Iron Deficiency Anemia Paralytic Ileus
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Postgastrectomy Syndrome:



Diseases related to Postgastrectomy Syndrome

Symptoms & Phenotypes for Postgastrectomy Syndrome

UMLS symptoms related to Postgastrectomy Syndrome:


constipation, pain, postoperative, postoperative nausea and vomiting, vomiting following gastrointestinal surgery

MGI Mouse Phenotypes related to Postgastrectomy Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.73 AP1S2 INS NTS PYY SST VIP
2 growth/size/body region MP:0005378 9.63 AP1S2 GIP INS NTS PYY SST
3 adipose tissue MP:0005375 9.62 AP1S2 INS NTS PYY
4 homeostasis/metabolism MP:0005376 9.5 AP1S2 GIP INS NTS PYY SST
5 normal MP:0002873 9.02 GIP INS PYY SST VIP

Drugs & Therapeutics for Postgastrectomy Syndrome

Drugs for Postgastrectomy Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved, Investigational Phase 4,Phase 2,Not Applicable 51110-01-1, 38916-34-6 53481605
2 lanreotide Approved Phase 4,Phase 2 108736-35-2
3
Pasireotide Approved Phase 4,Phase 2 396091-73-9 9941444
4
Lactitol Investigational Phase 4 585-86-4 3871
5 Angiopeptin Phase 4,Phase 2
6 Hormones Phase 4,Phase 2,Not Applicable
7 Hormone Antagonists Phase 4,Phase 2,Not Applicable
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Not Applicable
9 Pharmaceutical Solutions Phase 2
10
Empagliflozin Approved Not Applicable 864070-44-0
11
Rifaximin Approved, Investigational Not Applicable 80621-81-4 6436173
12 Antirheumatic Agents Not Applicable
13 Insulin, Globin Zinc Not Applicable
14 Hypoglycemic Agents Not Applicable
15 insulin Not Applicable
16 Interleukin 1 Receptor Antagonist Protein Not Applicable
17 Gastrointestinal Agents Not Applicable
18 Anti-Infective Agents Not Applicable
19 Nucleic Acid Synthesis Inhibitors Not Applicable
20 Anti-Bacterial Agents Not Applicable
21 Antibiotics, Antitubercular Not Applicable
22 Incretins Not Applicable
23 glucagon Not Applicable
24 Glucagon-Like Peptide 1 Not Applicable

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Treatment of the Dumping Syndrome With Lanreotide Autogel® Unknown status NCT00543179 Phase 4 Somatuline (Lanreotide Autogel®)
2 Study to Allow Access to Pasireotide for Patients Benefiting From Pasireotide Treatment in a Novartis-sponsored Study. Recruiting NCT01794793 Phase 4 Pasireotide
3 Comparison Study for Bile Reflux and Gastric Stasis in Patients After Distal Gastrectomy Withdrawn NCT00622804 Phase 3
4 SOMATULINE Autogel 90 mg IN DUMPING SYNDROME Unknown status NCT01923649 Phase 2 Lanreotide 90 mg slow release formulation;Placebo
5 Study to Assess Safety and Efficacy of sc Pasireotide in Patients With Dumping Syndrome Completed NCT01895296 Phase 2 Pasireotide;Placebo
6 Phase II Study Evaluating Efficacy, Safety and Pharmacokinetics of Pasireotide in Patients With Dumping Syndrome Completed NCT01637272 Phase 2 SOM230
7 Postprandial Hypoglycemia in Patients After Bariatric Surgery With Empagliflozin and Anakinra - The Hypo-BEAR-Study Completed NCT03200782 Not Applicable Empagliflozin;Anakinra
8 Impact of an Educational Personalized Clinical Support Device Preventive and a Referent Nurse in Surgery for Obesity Recruiting NCT02891330 Not Applicable
9 Metabolic Consequences of Gastrointestinal Surgery Recruiting NCT02836353 Not Applicable Somatostatin;Rifaximin
10 Dumping Syndrome After Operation of Esophageal Atresia Type III Recruiting NCT02525705 Not Applicable
11 Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery Enrolling by invitation NCT03734627 Octreotide Acetate;Saline Solution;Paracetamol;Sulfasalazine
12 Gastrectomy, Eating Behaviour and GLP-1 Enrolling by invitation NCT02971631 Not Applicable

Search NIH Clinical Center for Postgastrectomy Syndrome

Cochrane evidence based reviews: postgastrectomy syndromes

Genetic Tests for Postgastrectomy Syndrome

Anatomical Context for Postgastrectomy Syndrome

MalaCards organs/tissues related to Postgastrectomy Syndrome:

41
Testes, Pituitary, Pancreas, Thyroid

Publications for Postgastrectomy Syndrome

Articles related to Postgastrectomy Syndrome:

(show top 50) (show all 67)
# Title Authors Year
1
Quality of life after total vs distal gastrectomy with Roux-en-Y reconstruction: Use of the Postgastrectomy Syndrome Assessment Scale-45. ( 28373774 )
2017
2
Postgastrectomy Syndromes and Nutritional Considerations Following Gastric Surgery. ( 28325187 )
2017
3
Assessment of postoperative quality of life following pylorus-preserving gastrectomy and Billroth-I distal gastrectomy in gastric cancer patients: results of the nationwide postgastrectomy syndrome assessment study. ( 25637175 )
2015
4
Long-term quality-of-life comparison of total gastrectomy and proximal gastrectomy by Postgastrectomy Syndrome Assessment Scale (PGSAS-45): a nationwide multi-institutional study. ( 24801198 )
2014
5
Evaluation of postgastrectomy symptoms after distal gastrectomy with Billroth-I reconstruction using the Postgastrectomy Syndrome Assessment Scale-45 (PGSAS-45). ( 25091080 )
2014
6
Postgastrectomy Syndrome Assessment Scale (PGSAS)-45 and changes in body weight are useful tools for evaluation of reconstruction methods following distal gastrectomy. ( 24590434 )
2014
7
Characteristics and clinical relevance of postgastrectomy syndrome assessment scale (PGSAS)-45: newly developed integrated questionnaires for assessment of living status and quality of life in postgastrectomy patients. ( 24515247 )
2014
8
Postgastrectomy syndromes. ( 21889032 )
2011
9
Postgastrectomy syndromes--diagnosis and treatment. ( 15494286 )
2004
10
Pathophysiological studies on the relationship between postgastrectomy syndrome and gastric emptying function at 5 years after pylorus-preserving distal gastrectomy for early gastric cancer. ( 12734683 )
2003
11
Jejunal interposition to prevent postgastrectomy syndromes (Br J Surg 2000; 87: 1576-9). ( 11412275 )
2001
12
Jejunal interposition to prevent postgastrectomy syndromes. ( 11091248 )
2000
13
Delayed ulcer recurrence after gastric resection: a new postgastrectomy syndrome? ( 9393258 )
1997
14
Postgastrectomy syndromes: dumping and diarrhea. ( 8070912 )
1994
15
Early postoperative and postgastrectomy syndromes. Diagnosis, management, and prevention. ( 8070910 )
1994
16
The value of sham-feeding tests in patients with postgastrectomy syndromes. ( 8368935 )
1993
17
Postgastrectomy syndromes. ( 1549803 )
1992
18
Surgical options in postgastrectomy syndromes. ( 1989110 )
1991
19
The Roux operation for postgastrectomy syndromes. ( 1990879 )
1991
20
Management of postgastrectomy syndromes. ( 2294803 )
1990
21
Postgastrectomy syndromes. ( 3589901 )
1987
22
Small-bowel bacterial overgrowth in the postgastrectomy syndrome. ( 6369509 )
1983
23
Postgastrectomy syndromes. ( 7025276 )
1981
24
Remedial operation for alkaline reflux gastritis and associated postgastrectomy syndromes. ( 7362463 )
1980
25
Treatment of postgastrectomy syndromes. ( 7386983 )
1980
26
Continuing education examination: pre-test and post-test: treatment of postgastrectomy syndromes. ( 7386993 )
1980
27
The use of stapling devices in the management of postgastrectomy syndromes. ( 507539 )
1979
28
Gastric phytobezoar: still another postgastrectomy syndrome. ( 626436 )
1978
29
Postgastrectomy syndromes. ( 1267099 )
1976
30
Surgical treatment of late postgastrectomy syndromes. ( 1211535 )
1975
31
Surgical management of postgastrectomy syndrome. ( 4841119 )
1974
32
Jejunal transposition in treatment of postgastrectomy syndromes. ( 4453806 )
1974
33
Reversed intestinal segments in treatment of postgastrectomy syndromes. Case report. ( 4846760 )
1974
34
Postgastrectomy syndromes. ( 4934865 )
1971
35
Postgastrectomy syndromes and their management. ( 5314204 )
1971
36
Postgastrectomy syndrome. A clinical study based upon 100 patients. ( 5274413 )
1970
37
Remedial operations for postgastrectomy syndromes. ( 5433925 )
1970
38
Jejunal segments for the postgastrectomy syndromes. ( 5779138 )
1969
39
The value of the B II-BI conversion operation in the treatment of the postgastrectomy syndrome. ( 5713448 )
1968
40
Clinical experiences with jejunal interposition for postgastrectomy syndrome. ( 6083245 )
1967
41
Postgastrectomy syndromes. ( 6036134 )
1967
42
Jejunal interposition for certain postgastrectomy syndromes. ( 5905046 )
1966
43
Postgastrectomy syndromes. ( 5934620 )
1966
44
THE USE OF SEROTONIN ANTAGONISTS IN POSTGASTRECTOMY SYNDROMES. ( 14248301 )
1965
45
THE EXCRETION OF 5-HYDROXYINDOLEACETIC ACID IN THE POSTGASTRECTOMY SYNDROME. ( 14179358 )
1964
46
LATE POST-GASTRECTOMY SYNDROMES. THE PLACE OF SURGERY IN THE TREATMENT OF POSTGASTRECTOMY SYNDROMES. ( 14178941 )
1964
47
The postgastrectomy syndromes. Review of the literature, elucidation of mechanisms and a resume of personal experience. ( 14450602 )
1962
48
Jejunal loop interposition. A case of interposition for postgastrectomy syndrome following the Billroth II operation. ( 13782971 )
1961
49
The postgastrectomy syndromes. ( 13867303 )
1961
50
A case of the late symptoms of the postgastrectomy syndrome. ( 13681931 )
1960

Variations for Postgastrectomy Syndrome

Expression for Postgastrectomy Syndrome

Search GEO for disease gene expression data for Postgastrectomy Syndrome.

Pathways for Postgastrectomy Syndrome

Pathways related to Postgastrectomy Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.8 GIP INS NTS PYY SST VIP

GO Terms for Postgastrectomy Syndrome

Cellular components related to Postgastrectomy Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 GIP INS NTS PYY SST VIP
2 transport vesicle GO:0030133 8.96 INS NTS

Biological processes related to Postgastrectomy Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.43 GIP INS NTS PYY SST VIP
2 regulation of protein localization GO:0032880 9.37 INS VIP
3 response to amino acid GO:0043200 9.32 GIP SST
4 positive regulation of blood vessel diameter GO:0097755 9.26 INS VIP
5 response to acidic pH GO:0010447 9.16 GIP SST
6 regulation of signaling receptor activity GO:0010469 9.1 GIP INS NTS PYY SST VIP

Molecular functions related to Postgastrectomy Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.13 NTS PYY VIP
2 hormone activity GO:0005179 9.02 GIP INS PYY SST VIP

Sources for Postgastrectomy Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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