MCID: PST035
MIFTS: 36

Postgastrectomy Syndrome

Categories: Gastrointestinal diseases

Aliases & Classifications for Postgastrectomy Syndrome

MalaCards integrated aliases for Postgastrectomy Syndrome:

Name: Postgastrectomy Syndrome 12 15
Postgastrectomy Syndromes 44 70
Postgastric Surgery Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8439
ICD9CM 34 564.2
MeSH 44 D011178
SNOMED-CT 67 266527005
ICD10 32 K91.1
UMLS 70 C0032763

Summaries for Postgastrectomy Syndrome

MalaCards based summary : Postgastrectomy Syndrome, also known as postgastrectomy syndromes, is related to gastritis and bile reflux, and has symptoms including constipation, pain, postoperative and postoperative nausea and vomiting. An important gene associated with Postgastrectomy Syndrome is GCG (Glucagon), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. Affiliated tissues include small intestine, lymph node and pancreas, and related phenotype is digestive/alimentary.

Related Diseases for Postgastrectomy Syndrome

Diseases related to Postgastrectomy Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 172)
# Related Disease Score Top Affiliating Genes
1 gastritis 29.8 SST GHRL GAST
2 bile reflux 29.7 MLN GAST ATP12A
3 lactose intolerance 29.6 SI INS ATP12A
4 microinvasive gastric cancer 29.6 GAST ATP12A
5 peptic esophagitis 29.4 MLN GAST ATP12A
6 hernia, hiatus 29.1 MLN GHRL GAST ATP12A
7 peptic ulcer disease 29.1 SST GHRL GAST ATP12A
8 duodenogastric reflux 28.7 SST PYY NTS MLN GAST ATP12A
9 dumping syndrome 28.6 SST PYY NTS MLN INS GIP
10 diarrhea 28.2 SST SI PYY NTS MLN MGAM
11 constipation 27.8 SST PYY NTS MLN INS GHRL
12 afferent loop syndrome 11.1
13 splenic flexure cancer 10.3 INS GCG
14 angular cheilitis 10.3 SST GCG
15 bile acid malabsorption, primary 10.3 SST GCG
16 meckel diverticulum 10.3 SST GCG
17 acidophil adenoma 10.3 SST INS
18 adenosquamous bile duct carcinoma 10.3 GIP GCG
19 functional colonic disease 10.3 SST MLN
20 pituitary infarct 10.3 SST INS
21 acute insulin response 10.3 INS GCG
22 colonic pseudo-obstruction 10.2 SST MLN
23 transient refractive change 10.2 SST INS
24 pituitary apoplexy 10.2 SST INS
25 pancreatoblastoma 10.2 SST NTS
26 hyperpituitarism 10.2 SST INS
27 gastric hemangioma 10.2 SST ATP12A
28 diencephalic astrocytoma 10.2 INS GHRL
29 idiopathic gastroparesis 10.2 GIP GHRL
30 carcinoid syndrome 10.2 SST PYY NTS
31 biliary dyskinesia 10.1 SST ATP12A
32 pituitary gland disease 10.1 SST INS GCG
33 hyperinsulinemic hypoglycemia 10.1 SST INS GCG
34 hypoglycemia 10.1 SST INS GCG
35 active peptic ulcer disease 10.1 SST ATP12A
36 autonomic nervous system disease 10.1 INS GCG
37 mediastinitis 10.1 INS ATP12A
38 rumination disorder 10.1 MLN ATP12A
39 maturity-onset diabetes of the young, type 1 10.1 INS GCG
40 blind loop syndrome 10.1 MLN ATP12A
41 angiodysplasia 10.1 SST ATP12A
42 teratoma 10.1 SST INS GCG
43 lymphocytic colitis 10.1 PYY ATP12A
44 alzheimer disease 9 10.1 INS GHRL
45 abnormality of glucagon secretion 10.1 SST GHRL GCG
46 glossitis 10.1 GCG ATP12A
47 esophagitis 10.1
48 dyskinesia of esophagus 10.1 MLN ATP12A
49 eating disorder 10.1 PYY GHRL GCG
50 drug allergy 10.1 INS ATP12A

Comorbidity relations with Postgastrectomy Syndrome via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Esophagitis Intestinal Obstruction
Iron Deficiency Anemia Paralytic Ileus
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Postgastrectomy Syndrome:



Diseases related to Postgastrectomy Syndrome

Symptoms & Phenotypes for Postgastrectomy Syndrome

UMLS symptoms related to Postgastrectomy Syndrome:


constipation; pain, postoperative; postoperative nausea and vomiting; vomiting following gastrointestinal surgery

MGI Mouse Phenotypes related to Postgastrectomy Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.1 ATP12A GAST GHRL GIP INS SST

Drugs & Therapeutics for Postgastrectomy Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 MAgnetic Gastrointestinal Universal Septotome: a Safety and Feasibility Study Recruiting NCT04480216

Search NIH Clinical Center for Postgastrectomy Syndrome

Cochrane evidence based reviews: postgastrectomy syndromes

Genetic Tests for Postgastrectomy Syndrome

Anatomical Context for Postgastrectomy Syndrome

MalaCards organs/tissues related to Postgastrectomy Syndrome:

40
Small Intestine, Lymph Node, Pancreas, Thyroid

Publications for Postgastrectomy Syndrome

Articles related to Postgastrectomy Syndrome:

(show top 50) (show all 233)
# Title Authors PMID Year
1
Feasibility and quality of life assessment of laparoscopic proximal gastrectomy using double-tract reconstruction. 61
33452650 2021
2
Comparison of Postoperative Quality of Life among Three Different Reconstruction Methods After Proximal Gastrectomy: Insights From the PGSAS Study. 61
32506229 2020
3
Severity of postgastrectomy syndrome and quality of life after advanced gastric cancer radical gastrectomy. 61
32714536 2020
4
Evaluation of postoperative quality of life by PGSAS-45 following local gastrectomy based on the sentinel lymph node concept in early gastric cancer. 61
32086650 2020
5
Delta-shaped anastomosis vs circular stapler anastomosis after laparoscopic distal gastrectomy with Billroth I reconstruction: A randomized controlled trial. 61
31814306 2020
6
Short-term and long-term comparisons of laparoscopy-assisted proximal gastrectomy with esophagogastrostomy by the double-flap technique and laparoscopy-assisted total gastrectomy for proximal gastric cancer. 61
33180871 2020
7
Rikkunshito for upper gastrointestinal symptoms: A systematic review and meta-analysis. 61
30670250 2019
8
Background factors influencing postgastrectomy syndromes after various types of gastrectomy. 61
30613669 2018
9
Quality of life after proximal gastrectomy a review. 61
30441989 2018
10
Preservation of duodenal passage as a determinant of short- and long-term quality of life in gastric cancer patients after total gastrectomy. 61
28425683 2017
11
Predictive factors for body weight loss and its impact on quality of life following gastrectomy. 61
28765704 2017
12
Postgastrectomy Syndromes and Nutritional Considerations Following Gastric Surgery. 61
28325187 2017
13
Postoperative quality of life after laparoscopy-assisted pylorus-preserving gastrectomy compared With laparoscopy-assisted distal gastrectomy: A cross-sectional postal questionnaire survey. 61
27751530 2017
14
Quality of life after total vs distal gastrectomy with Roux-en-Y reconstruction: Use of the Postgastrectomy Syndrome Assessment Scale-45. 61
28373774 2017
15
Extreme dilatation of the interposed jejunal pouch after proximal gastrectomy associated with portal venous gas: A case report. 61
28715720 2017
16
Impaired Gastrointestinal Function Affects Symptoms and Alimentary Status in Patients After Gastrectomy. 61
27357933 2016
17
Factors affecting the quality of life of patients after gastrectomy as assessed using the newly developed PGSAS-45 scale: A nationwide multi-institutional study. 61
27833389 2016
18
Diminished Gastric Resection Preserves Better Quality of Life in Patients with Early Gastric Cancer. 61
27094837 2016
19
Assessment of postoperative quality of life following pylorus-preserving gastrectomy and Billroth-I distal gastrectomy in gastric cancer patients: results of the nationwide postgastrectomy syndrome assessment study. 61
25637175 2016
20
ASSESSMENT OF THE GASTRO-JEJUNO-DUODENAL TRANSIT AFTER JEJUNAL POUCH INTERPOSITION. 61
26734789 2015
21
[RESULTS OF GASTROPLASTY, USING ILEOCECAL SEGMENT OF INTESTINE AFTER COMBINED GASTRECTOMY]. 61
26939418 2015
22
Optimal Roux-en-Y reconstruction after distal gastrectomy for early gastric cancer as assessed using the newly developed PGSAS-45 scale. 61
25631461 2015
23
Evaluation of postgastrectomy symptoms after distal gastrectomy with Billroth-I reconstruction using the Postgastrectomy Syndrome Assessment Scale-45 (PGSAS-45). 61
25091080 2015
24
Long-term quality-of-life comparison of total gastrectomy and proximal gastrectomy by postgastrectomy syndrome assessment scale (PGSAS-45): a nationwide multi-institutional study. 61
24801198 2015
25
Factors that minimize postgastrectomy symptoms following pylorus-preserving gastrectomy: assessment using a newly developed scale (PGSAS-45). 61
24760336 2015
26
Characteristics and clinical relevance of postgastrectomy syndrome assessment scale (PGSAS)-45: newly developed integrated questionnaires for assessment of living status and quality of life in postgastrectomy patients. 61
24515247 2015
27
Assessment of motor function of the remnant stomach by ¹³C breath test with special reference to gastric local resection. 61
24934641 2014
28
Postgastrectomy Syndrome Assessment Scale (PGSAS)-45 and changes in body weight are useful tools for evaluation of reconstruction methods following distal gastrectomy. 61
24590434 2014
29
Roux-en-Y limb motility after total gastrectomy. 61
24496746 2014
30
[State of duodenal patency in patients with postgastrectomy syndromes]. 61
25042190 2014
31
Effects of rikkunshito, a kampo medicine, on quality of life after proximal gastrectomy. 61
23856127 2013
32
Endoscopic treatment of efferent loop syndrome with insertion of double pigtail stent. 61
24222968 2013
33
[Improving the quality of life after gastrectomy is the next issue after saving the lives of patients with gastric cancer]. 61
22413550 2012
34
[Postgastrectomy symptoms following total gastrectomy with or without preservation of the duodenal passage]. 61
22169340 2011
35
Postgastrectomy syndromes. 61
21889032 2011
36
[Postgastrectomy syndromes in therapeutic practice ]. 61
22416446 2011
37
[The Roux reconstruction for the correction of postresectional and postgastrectomy syndromes]. 61
22408798 2011
38
Improved long-term quality of life in patients with laparoscopy-assisted distal gastrectomy with jejunal pouch interposition for early gastric cancer. 61
20443144 2010
39
Gastric emptying function in patients 5 years after pylorus-preserving distal gastrectomy with or without preserving pyloric and hepatic branches of the vagal nerve for early gastric cancer. 61
19649759 2009
40
Functional evaluation after vagus-nerve-sparing laparoscopically assisted distal gastrectomy. 61
18594924 2008
41
Simultaneous dynamic study of gastric emptying and changes of serum levels of gut hormones in patients after peptic ulcer surgery. 61
16791805 2006
42
Pylorus-preserving gastrectomy in gastric cancer surgery--open and laparoscopic approaches. 61
16096761 2005
43
[Late follow-up of gastrectomized patients for peptic ulcer: clinical, endoscopic and histopathological aspects]. 61
16200249 2005
44
[Surgical treatment of diseases of operated stomach]. 61
16044124 2005
45
[Postgastrectomy syndrome and its management]. 61
15685879 2005
46
Postgastrectomy syndromes--diagnosis and treatment. 61
15494286 2004
47
Altered contractile responsiveness in ileal longitudinal muscle after total gastrectomy in a rat model. 61
14745614 2004
48
Pathophysiological studies on the relationship between postgastrectomy syndrome and gastric emptying function at 5 years after pylorus-preserving distal gastrectomy for early gastric cancer. 61
12734683 2003
49
New type of reconstruction method after subtotal gastrectomy (Noh's operation). 61
12715224 2003
50
Reconstruction after distal gastrectomy by interposition of a double-jejunal pouch using a triangulating stapling technique. 61
12658493 2003

Variations for Postgastrectomy Syndrome

Expression for Postgastrectomy Syndrome

Search GEO for disease gene expression data for Postgastrectomy Syndrome.

Pathways for Postgastrectomy Syndrome

GO Terms for Postgastrectomy Syndrome

Cellular components related to Postgastrectomy Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 SST PYY INS GIP GHRL GCG
2 endoplasmic reticulum lumen GO:0005788 9.56 INS GIP GHRL GCG
3 extracellular region GO:0005576 9.32 SST PYY NTS MLN MGAM INS
4 secretory granule lumen GO:0034774 9.26 INS GIP GHRL GCG

Biological processes related to Postgastrectomy Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 9.37 GHRL GCG
2 response to amino acid GO:0043200 9.32 SST GIP
3 G protein-coupled receptor signaling pathway GO:0007186 9.28 SST PYY NTS MLN INS GIP
4 feeding behavior GO:0007631 9.26 PYY GCG
5 response to acidic pH GO:0010447 9.16 SST GIP
6 polysaccharide digestion GO:0044245 8.96 SI MGAM

Molecular functions related to Postgastrectomy Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 9.32 SI MGAM
2 neuropeptide hormone activity GO:0005184 9.26 PYY NTS
3 hormone activity GO:0005179 9.23 SST PYY MLN INS GIP GHRL
4 alpha-1,4-glucosidase activity GO:0004558 9.16 SI MGAM
5 glucagon receptor binding GO:0031769 8.96 GIP GCG

Sources for Postgastrectomy Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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