MCID: PST035
MIFTS: 36

Postgastrectomy Syndrome

Categories: Gastrointestinal diseases

Aliases & Classifications for Postgastrectomy Syndrome

MalaCards integrated aliases for Postgastrectomy Syndrome:

Name: Postgastrectomy Syndrome 12 15
Postgastrectomy Syndromes 44 73
Postgastric Surgery Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8439
ICD10 33 K91.1
ICD9CM 35 564.2
MeSH 44 D011178
UMLS 73 C0032763

Summaries for Postgastrectomy Syndrome

MalaCards based summary : Postgastrectomy Syndrome, also known as postgastrectomy syndromes, is related to dumping syndrome and pancreatoblastoma, and has symptoms including constipation, pain, postoperative and vomiting following gastrointestinal surgery. An important gene associated with Postgastrectomy Syndrome is SST (Somatostatin), and among its related pathways/superpathways is Signaling by GPCR. The drugs lanreotide and Somatostatin have been mentioned in the context of this disorder. Related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Postgastrectomy Syndrome

Diseases related to Postgastrectomy Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 dumping syndrome 28.7 GIP INS NTS PYY SST
2 pancreatoblastoma 10.5 NTS SST
3 zollinger-ellison syndrome 10.4 NTS SST
4 wdha syndrome 10.4 SST VIP
5 duodenal somatostatinoma 10.4 INS SST
6 postural hypotension 10.3 INS SST
7 glucagonoma 10.3 SST VIP
8 hyperinsulinemic hypoglycemia, familial, 2 10.3 INS SST
9 hyperpituitarism 10.3 INS SST
10 secretory diarrhea 10.3 SST VIP
11 cryptosporidiosis 10.3 SST VIP
12 binswanger's disease 10.3 SST VIP
13 pituitary-dependent cushing's disease 10.3 INS SST
14 pituitary gland disease 10.3 INS SST
15 hyperinsulinemic hypoglycemia 10.3 INS SST
16 hyperprolactinemia 10.2 SST VIP
17 cell type benign neoplasm 10.2 INS SST
18 duodenal ulcer 10.2 INS SST
19 autonomic nervous system neoplasm 10.2 NTS VIP
20 gallbladder disease 10.2 INS SST
21 endocrine gland cancer 10.2 SST VIP
22 acromegaly 10.1 INS SST
23 hyperthyroidism 10.1 INS SST
24 insulinoma 10.0 INS SST
25 pertussis 10.0 SST VIP
26 serotonin syndrome 9.9 PYY SST
27 vipoma 9.9 NTS SST VIP
28 gastric cancer 9.9
29 somatostatinoma 9.8 INS SST VIP
30 gastrinoma 9.8 INS SST VIP
31 islet cell tumor 9.8 INS SST VIP
32 hyperinsulinism 9.8 INS SST
33 arteries, anomalies of 9.8
34 coronary artery anomaly 9.8
35 microinvasive gastric cancer 9.8
36 pancreatitis 9.8
37 multiple endocrine neoplasia, type i 9.7 INS SST VIP
38 pancreatic cholera 9.7 GIP SST VIP
39 neuroendocrine tumor 9.7 NTS SST
40 endocrine pancreas disease 9.6 GIP INS SST
41 overnutrition 9.6 INS PYY
42 pancreas disease 9.6 GIP INS SST
43 glucose metabolism disease 9.6 GIP INS SST
44 acquired metabolic disease 9.6 GIP INS SST
45 hyperglycemia 9.6 GIP INS SST
46 morbid obesity 9.6 INS PYY
47 duodenogastric reflux 9.6 NTS PYY SST
48 carcinoid syndrome 9.6 NTS PYY SST
49 short bowel syndrome 9.5 NTS PYY SST
50 gastrointestinal system disease 9.5 PYY SST

Comorbidity relations with Postgastrectomy Syndrome via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Esophagitis Intestinal Obstruction
Iron Deficiency Anemia Paralytic Ileus
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Postgastrectomy Syndrome:



Diseases related to Postgastrectomy Syndrome

Symptoms & Phenotypes for Postgastrectomy Syndrome

UMLS symptoms related to Postgastrectomy Syndrome:


constipation, pain, postoperative, vomiting following gastrointestinal surgery, postoperative nausea and vomiting

MGI Mouse Phenotypes related to Postgastrectomy Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.73 AP1S2 INS NTS PYY SST VIP
2 growth/size/body region MP:0005378 9.63 AP1S2 GIP INS NTS PYY SST
3 adipose tissue MP:0005375 9.62 AP1S2 INS NTS PYY
4 homeostasis/metabolism MP:0005376 9.5 AP1S2 GIP INS NTS PYY SST
5 normal MP:0002873 9.02 GIP INS PYY SST VIP

Drugs & Therapeutics for Postgastrectomy Syndrome

Drugs for Postgastrectomy Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 lanreotide Approved Phase 4,Phase 2 108736-35-2
2
Somatostatin Approved, Investigational Phase 4,Phase 2,Not Applicable 38916-34-6, 51110-01-1 53481605
3
Lactitol Investigational Phase 4 585-86-4 3871
4 Hormone Antagonists Phase 4,Phase 2,Not Applicable
5 Hormones Phase 4,Phase 2,Not Applicable
6 Angiopeptin Phase 4,Phase 2
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Not Applicable
8 Pharmaceutical Solutions Phase 2
9
Empagliflozin Approved Not Applicable 864070-44-0
10
Rifaximin Approved, Investigational Not Applicable 80621-81-4 6436173
11 insulin Not Applicable
12 Gastrointestinal Agents Not Applicable
13 Nucleic Acid Synthesis Inhibitors Not Applicable
14 Anti-Bacterial Agents Not Applicable
15 Hypoglycemic Agents Not Applicable
16 Antibiotics, Antitubercular Not Applicable
17 Anti-Infective Agents Not Applicable
18 Insulin, Globin Zinc Not Applicable
19 Interleukin 1 Receptor Antagonist Protein Not Applicable
20 Antirheumatic Agents Not Applicable
21 glucagon Not Applicable
22 Glucagon-Like Peptide 1 Not Applicable
23 Incretins Not Applicable

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Treatment of the Dumping Syndrome With Lanreotide Autogel® Unknown status NCT00543179 Phase 4 Somatuline (Lanreotide Autogel®)
2 Study to Allow Access to Pasireotide for Patients Benefiting From Pasireotide Treatment in a Novartis-sponsored Study. Recruiting NCT01794793 Phase 4 Pasireotide
3 Comparison Study for Bile Reflux and Gastric Stasis in Patients After Distal Gastrectomy Withdrawn NCT00622804 Phase 3
4 SOMATULINE Autogel 90 mg IN DUMPING SYNDROME Unknown status NCT01923649 Phase 2 Lanreotide 90 mg slow release formulation;Placebo
5 Study to Assess Safety and Efficacy of sc Pasireotide in Patients With Dumping Syndrome Completed NCT01895296 Phase 2 Pasireotide;Placebo
6 Phase II Study Evaluating Efficacy, Safety and Pharmacokinetics of Pasireotide in Patients With Dumping Syndrome Completed NCT01637272 Phase 2 SOM230
7 Postprandial Hypoglycemia in Patients After Bariatric Surgery With Empagliflozin and Anakinra - The Hypo-BEAR-Study Recruiting NCT03200782 Not Applicable Empagliflozin;Anakinra
8 Impact of an Educational Personalized Clinical Support Device Preventive and a Referent Nurse in Surgery for Obesity Recruiting NCT02891330 Not Applicable
9 Metabolic Consequences of Gastrointestinal Surgery Recruiting NCT02836353 Not Applicable Somatostatin;Rifaximin
10 Dumping Syndrome After Operation of Esophageal Atresia Type III Recruiting NCT02525705 Not Applicable
11 Gastrectomy, Eating Behaviour and GLP-1 Enrolling by invitation NCT02971631 Not Applicable

Search NIH Clinical Center for Postgastrectomy Syndrome

Cochrane evidence based reviews: postgastrectomy syndromes

Genetic Tests for Postgastrectomy Syndrome

Anatomical Context for Postgastrectomy Syndrome

Publications for Postgastrectomy Syndrome

Articles related to Postgastrectomy Syndrome:

(show all 27)
# Title Authors Year
1
Quality of life after total vs distal gastrectomy with Roux-en-Y reconstruction: Use of the Postgastrectomy Syndrome Assessment Scale-45. ( 28373774 )
2017
2
Assessment of postoperative quality of life following pylorus-preserving gastrectomy and Billroth-I distal gastrectomy in gastric cancer patients: results of the nationwide postgastrectomy syndrome assessment study. ( 25637175 )
2015
3
Long-term quality-of-life comparison of total gastrectomy and proximal gastrectomy by Postgastrectomy Syndrome Assessment Scale (PGSAS-45): a nationwide multi-institutional study. ( 24801198 )
2014
4
Evaluation of postgastrectomy symptoms after distal gastrectomy with Billroth-I reconstruction using the Postgastrectomy Syndrome Assessment Scale-45 (PGSAS-45). ( 25091080 )
2014
5
Postgastrectomy Syndrome Assessment Scale (PGSAS)-45 and changes in body weight are useful tools for evaluation of reconstruction methods following distal gastrectomy. ( 24590434 )
2014
6
Characteristics and clinical relevance of postgastrectomy syndrome assessment scale (PGSAS)-45: newly developed integrated questionnaires for assessment of living status and quality of life in postgastrectomy patients. ( 24515247 )
2014
7
Pathophysiological studies on the relationship between postgastrectomy syndrome and gastric emptying function at 5 years after pylorus-preserving distal gastrectomy for early gastric cancer. ( 12734683 )
2003
8
Delayed ulcer recurrence after gastric resection: a new postgastrectomy syndrome? ( 9393258 )
1997
9
Small-bowel bacterial overgrowth in the postgastrectomy syndrome. ( 6369509 )
1983
10
Gastric phytobezoar: still another postgastrectomy syndrome. ( 626436 )
1978
11
Surgical management of postgastrectomy syndrome. ( 4841119 )
1974
12
Postgastrectomy syndrome. A clinical study based upon 100 patients. ( 5274413 )
1970
13
The value of the B II-BI conversion operation in the treatment of the postgastrectomy syndrome. ( 5713448 )
1968
14
Clinical experiences with jejunal interposition for postgastrectomy syndrome. ( 6083245 )
1967
15
THE EXCRETION OF 5-HYDROXYINDOLEACETIC ACID IN THE POSTGASTRECTOMY SYNDROME. ( 14179358 )
1964
16
Jejunal loop interposition. A case of interposition for postgastrectomy syndrome following the Billroth II operation. ( 13782971 )
1961
17
A case of the late symptoms of the postgastrectomy syndrome. ( 13681931 )
1960
18
Post-gastrectomy pancreatic secretion; dietary management of patients with postgastrectomy syndrome. ( 13625745 )
1958
19
The postgastrectomy syndrome and coronary artery disease: report of a case. ( 13564997 )
1958
20
Cardiovascular changes in the postgastrectomy syndrome. ( 13548319 )
1958
21
The postgastrectomy syndrome: the place of enteroenterostomy in treatment. ( 13489576 )
1958
22
The postgastrectomy syndrome: studies on pathogenesis. ( 13412023 )
1957
23
The use of blood transfusions in the treatment of the postgastrectomy syndrome. ( 13495819 )
1957
24
Postgastrectomy syndrome. ( 13372202 )
1956
25
Esophagoduodenostomy, total gastrectomy and the postgastrectomy syndrome. ( 13156937 )
1954
26
Mechanism of the postgastrectomy syndrome. ( 18107958 )
1949
27
The postgastrectomy syndrome. ( 20295780 )
1947

Variations for Postgastrectomy Syndrome

Expression for Postgastrectomy Syndrome

Search GEO for disease gene expression data for Postgastrectomy Syndrome.

Pathways for Postgastrectomy Syndrome

Pathways related to Postgastrectomy Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.8 GIP INS NTS PYY SST VIP

GO Terms for Postgastrectomy Syndrome

Cellular components related to Postgastrectomy Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 GIP INS NTS PYY SST VIP
2 transport vesicle GO:0030133 8.96 INS NTS

Biological processes related to Postgastrectomy Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.5 INS PYY SST
2 response to glucose GO:0009749 9.43 GIP INS
3 G-protein coupled receptor signaling pathway GO:0007186 9.43 GIP INS NTS PYY SST VIP
4 response to nutrient levels GO:0031667 9.4 GIP INS
5 regulation of protein localization GO:0032880 9.37 INS VIP
6 response to amino acid GO:0043200 9.26 GIP SST
7 response to acidic pH GO:0010447 9.16 GIP SST
8 regulation of signaling receptor activity GO:0010469 9.1 GIP INS NTS PYY SST VIP

Molecular functions related to Postgastrectomy Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.13 NTS PYY VIP
2 hormone activity GO:0005179 9.02 GIP INS PYY SST VIP

Sources for Postgastrectomy Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....