MCID: PST035
MIFTS: 36

Postgastrectomy Syndrome

Categories: Gastrointestinal diseases

Aliases & Classifications for Postgastrectomy Syndrome

MalaCards integrated aliases for Postgastrectomy Syndrome:

Name: Postgastrectomy Syndrome 12 15
Postgastrectomy Syndromes 45 74
Postgastric Surgery Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8439
ICD9CM 36 564.2
MeSH 45 D011178
SNOMED-CT 69 80193009
ICD10 34 K91.1
UMLS 74 C0032763

Summaries for Postgastrectomy Syndrome

MalaCards based summary : Postgastrectomy Syndrome, also known as postgastrectomy syndromes, is related to dumping syndrome and diarrhea, and has symptoms including constipation, pain, postoperative and postoperative nausea and vomiting. An important gene associated with Postgastrectomy Syndrome is SST (Somatostatin). The drugs Somatostatin and lanreotide have been mentioned in the context of this disorder. Affiliated tissues include testes, and related phenotypes are adipose tissue and growth/size/body region

Related Diseases for Postgastrectomy Syndrome

Diseases related to Postgastrectomy Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 dumping syndrome 31.1 GIP INS NTS PYY SST
2 diarrhea 29.2 SI SST
3 vipoma 10.2 NTS SST
4 pancreatoblastoma 10.2 NTS SST
5 zollinger-ellison syndrome 10.2 NTS SST
6 duodenal somatostatinoma 10.2 INS SST
7 somatostatinoma 10.2 INS SST
8 pancreatic endocrine carcinoma 10.2 INS SST
9 insulinomatosis and diabetes mellitus 10.2 INS SST
10 insulinoma 10.2 INS SST
11 hyperpituitarism 10.2 INS SST
12 functional gastric disease 10.1 INS SST
13 pneumatosis cystoides intestinalis 10.1 PYY SST
14 pancreatic cystadenoma 10.1 INS SST
15 gastrinoma 10.1 INS SST
16 islet cell tumor 10.1 INS SST
17 gastrointestinal system benign neoplasm 10.1 INS SST
18 pituitary-dependent cushing's disease 10.1 INS SST
19 serotonin syndrome 10.1 PYY SST
20 endocrine organ benign neoplasm 10.1 INS SST
21 thyroid gland disease 10.1 INS SST
22 pituitary gland disease 10.1 INS SST
23 hyperinsulinemic hypoglycemia 10.1 INS SST
24 duodenal ulcer 10.1 INS SST
25 pancreatic cholera 10.1 GIP SST
26 cell type benign neoplasm 10.1 INS SST
27 acromegaly 10.1 INS SST
28 gastroesophageal reflux 10.1 NTS PYY
29 hyperthyroidism 10.0 INS SST
30 gastric cancer 10.0
31 microvascular complications of diabetes 1 10.0 INS SST
32 overnutrition 10.0 INS PYY
33 multiple endocrine neoplasia, type i 10.0 INS SST
34 neuroendocrine tumor 10.0 NTS SST
35 morbid obesity 10.0 INS PYY
36 insulin-like growth factor i 10.0 INS SST
37 duodenogastric reflux 10.0 NTS PYY SST
38 carcinoid syndrome 9.9 NTS PYY SST
39 short bowel syndrome 9.9 NTS PYY SST
40 constipation 9.9 NTS PYY SST
41 arteries, anomalies of 9.9
42 coronary artery anomaly 9.9
43 microinvasive gastric cancer 9.9
44 gastritis 9.9
45 degos 'en cocarde' erythrokeratoderma 9.9
46 gastrointestinal system disease 9.9 INS PYY SST
47 hyperinsulinism 9.9 INS SST
48 endocrine pancreas disease 9.8 GIP INS SST
49 pancreas disease 9.8 GIP INS SST
50 glucose metabolism disease 9.8 GIP INS SST

Comorbidity relations with Postgastrectomy Syndrome via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Esophagitis Intestinal Obstruction
Iron Deficiency Anemia Paralytic Ileus
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Postgastrectomy Syndrome:



Diseases related to Postgastrectomy Syndrome

Symptoms & Phenotypes for Postgastrectomy Syndrome

UMLS symptoms related to Postgastrectomy Syndrome:


constipation, pain, postoperative, postoperative nausea and vomiting, vomiting following gastrointestinal surgery

MGI Mouse Phenotypes related to Postgastrectomy Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.46 AP1S2 INS NTS PYY
2 growth/size/body region MP:0005378 9.43 AP1S2 GIP INS NTS PYY SST
3 homeostasis/metabolism MP:0005376 9.1 AP1S2 GIP INS NTS PYY SST

Drugs & Therapeutics for Postgastrectomy Syndrome

Drugs for Postgastrectomy Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved, Investigational Phase 4,Phase 2,Not Applicable 38916-34-6, 51110-01-1 53481605
2
lanreotide Approved Phase 4,Phase 2 108736-35-2
3
Pasireotide Approved Phase 4,Phase 2 396091-73-9 9941444
4
Lactitol Investigational Phase 4 585-86-4, 585-88-6 493591
5 Hormones Phase 4,Phase 2,Not Applicable
6 Hormone Antagonists Phase 4,Phase 2,Not Applicable
7 Angiopeptin Phase 4,Phase 2
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Not Applicable
9 Pharmaceutical Solutions Phase 2
10
Empagliflozin Approved Not Applicable 864070-44-0
11
Octreotide Approved, Investigational 83150-76-9 6400441 383414
12
Acetaminophen Approved 103-90-2 1983
13
Sulfasalazine Approved 599-79-1 5353980 5359476
14
Glucagon Approved Not Applicable 16941-32-5
15
Rifaximin Approved, Investigational Not Applicable 80621-81-4 6436173 46783403
16 Sodium-Glucose Transporter 2 Inhibitors Not Applicable
17 Antirheumatic Agents Not Applicable
18 Insulin, Globin Zinc Not Applicable
19 insulin Not Applicable
20 Hypoglycemic Agents Not Applicable
21 Interleukin 1 Receptor Antagonist Protein Not Applicable
22 Anti-Inflammatory Agents
23 Peripheral Nervous System Agents
24 Anti-Infective Agents ,Not Applicable
25 Glucagon-Like Peptide 1 ,Not Applicable
26 Nutrients
27 Anti-Inflammatory Agents, Non-Steroidal
28 Antipyretics
29 Analgesics
30 Antineoplastic Agents, Hormonal
31 Gastrointestinal Agents ,Not Applicable
32 Analgesics, Non-Narcotic
33 Incretins Not Applicable
34 Anti-Bacterial Agents Not Applicable
35 Antibiotics, Antitubercular Not Applicable

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Treatment of the Dumping Syndrome With Lanreotide Autogel® Unknown status NCT00543179 Phase 4 Somatuline (Lanreotide Autogel®)
2 Study to Allow Access to Pasireotide for Patients Benefiting From Pasireotide Treatment in a Novartis-sponsored Study. Recruiting NCT01794793 Phase 4 Pasireotide
3 Comparison Study for Bile Reflux and Gastric Stasis in Patients After Distal Gastrectomy Withdrawn NCT00622804 Phase 3
4 SOMATULINE Autogel 90 mg IN DUMPING SYNDROME Unknown status NCT01923649 Phase 2 Lanreotide 90 mg slow release formulation;Placebo
5 Study to Assess Safety and Efficacy of sc Pasireotide in Patients With Dumping Syndrome Completed NCT01895296 Phase 2 Pasireotide;Placebo
6 Phase II Study Evaluating Efficacy, Safety and Pharmacokinetics of Pasireotide in Patients With Dumping Syndrome Completed NCT01637272 Phase 2 SOM230
7 Postprandial Hypoglycemia in Patients After Bariatric Surgery With Empagliflozin and Anakinra - The Hypo-BEAR-Study Completed NCT03200782 Not Applicable Empagliflozin;Anakinra
8 Impact of an Educational Personalized Clinical Support Device Preventive and a Referent Nurse in Surgery for Obesity Recruiting NCT02891330 Not Applicable
9 Dumping Syndrome and Quality of Life After Vagus Nerve-preserving Distal Gastrectomy Recruiting NCT03880747
10 Dumping Syndrome After Operation of Esophageal Atresia Type III Recruiting NCT02525705 Not Applicable
11 Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery Enrolling by invitation NCT03734627 Octreotide Acetate;Saline Solution;Paracetamol;Sulfasalazine
12 Gastrectomy, Eating Behaviour and GLP-1 Enrolling by invitation NCT02971631 Not Applicable
13 Metabolic Consequences of Gastrointestinal Surgery Terminated NCT02836353 Not Applicable Somatostatin;Rifaximin

Search NIH Clinical Center for Postgastrectomy Syndrome

Cochrane evidence based reviews: postgastrectomy syndromes

Genetic Tests for Postgastrectomy Syndrome

Anatomical Context for Postgastrectomy Syndrome

MalaCards organs/tissues related to Postgastrectomy Syndrome:

42
Testes

Publications for Postgastrectomy Syndrome

Articles related to Postgastrectomy Syndrome:

(show top 50) (show all 68)
# Title Authors Year
1
Background factors influencing postgastrectomy syndromes after various types of gastrectomy. ( 30613669 )
2018
2
Quality of life after total vs distal gastrectomy with Roux-en-Y reconstruction: Use of the Postgastrectomy Syndrome Assessment Scale-45. ( 28373774 )
2017
3
Postgastrectomy Syndromes and Nutritional Considerations Following Gastric Surgery. ( 28325187 )
2017
4
Assessment of postoperative quality of life following pylorus-preserving gastrectomy and Billroth-I distal gastrectomy in gastric cancer patients: results of the nationwide postgastrectomy syndrome assessment study. ( 25637175 )
2015
5
Long-term quality-of-life comparison of total gastrectomy and proximal gastrectomy by Postgastrectomy Syndrome Assessment Scale (PGSAS-45): a nationwide multi-institutional study. ( 24801198 )
2014
6
Evaluation of postgastrectomy symptoms after distal gastrectomy with Billroth-I reconstruction using the Postgastrectomy Syndrome Assessment Scale-45 (PGSAS-45). ( 25091080 )
2014
7
Postgastrectomy Syndrome Assessment Scale (PGSAS)-45 and changes in body weight are useful tools for evaluation of reconstruction methods following distal gastrectomy. ( 24590434 )
2014
8
Characteristics and clinical relevance of postgastrectomy syndrome assessment scale (PGSAS)-45: newly developed integrated questionnaires for assessment of living status and quality of life in postgastrectomy patients. ( 24515247 )
2014
9
Postgastrectomy syndromes. ( 21889032 )
2011
10
Postgastrectomy syndromes--diagnosis and treatment. ( 15494286 )
2004
11
Pathophysiological studies on the relationship between postgastrectomy syndrome and gastric emptying function at 5 years after pylorus-preserving distal gastrectomy for early gastric cancer. ( 12734683 )
2003
12
Jejunal interposition to prevent postgastrectomy syndromes (Br J Surg 2000; 87: 1576-9). ( 11412275 )
2001
13
Jejunal interposition to prevent postgastrectomy syndromes. ( 11091248 )
2000
14
Delayed ulcer recurrence after gastric resection: a new postgastrectomy syndrome? ( 9393258 )
1997
15
Postgastrectomy syndromes: dumping and diarrhea. ( 8070912 )
1994
16
Early postoperative and postgastrectomy syndromes. Diagnosis, management, and prevention. ( 8070910 )
1994
17
The value of sham-feeding tests in patients with postgastrectomy syndromes. ( 8368935 )
1993
18
Postgastrectomy syndromes. ( 1549803 )
1992
19
Surgical options in postgastrectomy syndromes. ( 1989110 )
1991
20
The Roux operation for postgastrectomy syndromes. ( 1990879 )
1991
21
Management of postgastrectomy syndromes. ( 2294803 )
1990
22
Postgastrectomy syndromes. ( 3589901 )
1987
23
Small-bowel bacterial overgrowth in the postgastrectomy syndrome. ( 6369509 )
1983
24
Postgastrectomy syndromes. ( 7025276 )
1981
25
Remedial operation for alkaline reflux gastritis and associated postgastrectomy syndromes. ( 7362463 )
1980
26
Treatment of postgastrectomy syndromes. ( 7386983 )
1980
27
Continuing education examination: pre-test and post-test: treatment of postgastrectomy syndromes. ( 7386993 )
1980
28
The use of stapling devices in the management of postgastrectomy syndromes. ( 507539 )
1979
29
Gastric phytobezoar: still another postgastrectomy syndrome. ( 626436 )
1978
30
Postgastrectomy syndromes. ( 1267099 )
1976
31
Surgical treatment of late postgastrectomy syndromes. ( 1211535 )
1975
32
Surgical management of postgastrectomy syndrome. ( 4841119 )
1974
33
Jejunal transposition in treatment of postgastrectomy syndromes. ( 4453806 )
1974
34
Reversed intestinal segments in treatment of postgastrectomy syndromes. Case report. ( 4846760 )
1974
35
Postgastrectomy syndromes. ( 4934865 )
1971
36
Postgastrectomy syndromes and their management. ( 5314204 )
1971
37
Postgastrectomy syndrome. A clinical study based upon 100 patients. ( 5274413 )
1970
38
Remedial operations for postgastrectomy syndromes. ( 5433925 )
1970
39
Jejunal segments for the postgastrectomy syndromes. ( 5779138 )
1969
40
The value of the B II-BI conversion operation in the treatment of the postgastrectomy syndrome. ( 5713448 )
1968
41
Clinical experiences with jejunal interposition for postgastrectomy syndrome. ( 6083245 )
1967
42
Postgastrectomy syndromes. ( 6036134 )
1967
43
Jejunal interposition for certain postgastrectomy syndromes. ( 5905046 )
1966
44
Postgastrectomy syndromes. ( 5934620 )
1966
45
THE USE OF SEROTONIN ANTAGONISTS IN POSTGASTRECTOMY SYNDROMES. ( 14248301 )
1965
46
THE EXCRETION OF 5-HYDROXYINDOLEACETIC ACID IN THE POSTGASTRECTOMY SYNDROME. ( 14179358 )
1964
47
LATE POST-GASTRECTOMY SYNDROMES. THE PLACE OF SURGERY IN THE TREATMENT OF POSTGASTRECTOMY SYNDROMES. ( 14178941 )
1964
48
The postgastrectomy syndromes. Review of the literature, elucidation of mechanisms and a resume of personal experience. ( 14450602 )
1962
49
Jejunal loop interposition. A case of interposition for postgastrectomy syndrome following the Billroth II operation. ( 13782971 )
1961
50
The postgastrectomy syndromes. ( 13867303 )
1961

Variations for Postgastrectomy Syndrome

Expression for Postgastrectomy Syndrome

Search GEO for disease gene expression data for Postgastrectomy Syndrome.

Pathways for Postgastrectomy Syndrome

GO Terms for Postgastrectomy Syndrome

Cellular components related to Postgastrectomy Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule lumen GO:0034774 9.16 GIP INS
2 extracellular region GO:0005576 9.02 GIP INS NTS PYY SST
3 transport vesicle GO:0030133 8.96 INS NTS

Biological processes related to Postgastrectomy Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.35 GIP INS NTS PYY SST
2 response to amino acid GO:0043200 9.26 GIP SST
3 response to acidic pH GO:0010447 9.16 GIP SST
4 regulation of signaling receptor activity GO:0010469 9.02 GIP INS NTS PYY SST

Molecular functions related to Postgastrectomy Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 8.96 NTS PYY
2 hormone activity GO:0005179 8.92 GIP INS PYY SST

Sources for Postgastrectomy Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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