MCID: PST035
MIFTS: 37

Postgastrectomy Syndrome

Categories: Gastrointestinal diseases

Aliases & Classifications for Postgastrectomy Syndrome

MalaCards integrated aliases for Postgastrectomy Syndrome:

Name: Postgastrectomy Syndrome 12 15
Postgastrectomy Syndromes 43 71
Postgastric Surgery Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8439
ICD9CM 34 564.2
MeSH 43 D011178
SNOMED-CT 67 80193009
ICD10 32 K91.1
UMLS 71 C0032763

Summaries for Postgastrectomy Syndrome

MalaCards based summary : Postgastrectomy Syndrome, also known as postgastrectomy syndromes, is related to gastritis and lactose intolerance, and has symptoms including constipation, pain, postoperative and postoperative nausea and vomiting. An important gene associated with Postgastrectomy Syndrome is GCG (Glucagon), and among its related pathways/superpathways are Peptide ligand-binding receptors and cAMP signaling pathway. Affiliated tissues include testes, small intestine and lymph node, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Related Diseases for Postgastrectomy Syndrome

Diseases related to Postgastrectomy Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 gastritis 30.6 SST GHRL GAST
2 lactose intolerance 29.8 SI INS ATP12A
3 bile reflux 29.7 GAST CACNA1E ATP12A
4 peptic esophagitis 29.5 MLN GAST CACNA1E ATP12A
5 peptic ulcer disease 29.4 SST INS GHRL GAST ATP12A
6 hernia, hiatus 29.4 GHRL GAST ATP12A
7 dumping syndrome 29.2 SST SI PYY NTS MLN MGAM
8 diarrhea 28.4 SST SI PYY NTS MLN MGAM
9 duodenogastric reflux 28.1 SST PYY NTS MLN GAST CACNA1E
10 stomach disease 28.1 SST MLN INS GHRL GCG GAST
11 constipation 27.4 SST PYY NTS MLN INS GHRL
12 petrositis 10.5 SST GCG
13 angular cheilitis 10.4 SST GCG
14 bile acid malabsorption, primary 10.4 SST GCG
15 adenosquamous bile duct carcinoma 10.4 GIP GCG
16 pituitary infarct 10.4 SST INS
17 duodenal somatostatinoma 10.4 SST INS
18 acidophil adenoma 10.4 SST INS
19 acute insulin response 10.4 INS GCG
20 meckel diverticulum 10.4 SST GCG
21 transient refractive change 10.4 SST INS
22 chronic congestive splenomegaly 10.3 SST CACNA1E
23 pituitary apoplexy 10.3 SST INS
24 esophagitis 10.3
25 hyperpituitarism 10.3 SST INS
26 idiopathic gastroparesis 10.3 GIP GHRL
27 pancreas disease 10.3 SST INS GCG
28 functional colonic disease 10.3 SST MLN
29 maturity-onset diabetes of the young, type 2 10.3 INS GCG
30 hyperinsulinemic hypoglycemia 10.3 SST INS GCG
31 colonic pseudo-obstruction 10.3 SST MLN
32 mucormycosis 10.3 INS CACNA1E
33 carcinoid syndrome 10.3 SST PYY NTS
34 pituitary gland disease 10.3 SST INS GCG
35 pancreatoblastoma 10.2 SST NTS
36 gastric hemangioma 10.2 SST ATP12A
37 abnormality of glucagon secretion 10.2 SST GHRL GCG
38 teratoma 10.2 SST INS GCG
39 afferent loop syndrome 10.2
40 biliary dyskinesia 10.2 SST ATP12A
41 gastrointestinal neuroendocrine benign tumor 10.2 SST GAST
42 active peptic ulcer disease 10.2 SST ATP12A
43 non-functioning pancreatic endocrine tumor 10.2 SST GAST
44 rectum neuroendocrine neoplasm 10.2 SST GAST
45 mediastinitis 10.2 INS ATP12A
46 hypoglycemic coma 10.2 SI INS GCG
47 gastric neuroendocrine neoplasm 10.2 SST GAST
48 abdominal obesity-metabolic syndrome 1 10.2 INS GHRL GCG
49 appendix lymphoma 10.2 SST GAST
50 glucagonoma 10.2 SST GAST

Comorbidity relations with Postgastrectomy Syndrome via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Esophagitis Intestinal Obstruction
Iron Deficiency Anemia Paralytic Ileus
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Postgastrectomy Syndrome:



Diseases related to Postgastrectomy Syndrome

Symptoms & Phenotypes for Postgastrectomy Syndrome

UMLS symptoms related to Postgastrectomy Syndrome:


constipation, pain, postoperative, postoperative nausea and vomiting, vomiting following gastrointestinal surgery

MGI Mouse Phenotypes related to Postgastrectomy Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.43 ATP12A GAST GHRL GIP INS SST
2 homeostasis/metabolism MP:0005376 9.36 AP1S2 ATP12A CACNA1E GAST GHRL GIP

Drugs & Therapeutics for Postgastrectomy Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Study on Comparison for Bile Reflux and Gastric Stasis in Patients With Gastric Cancer After Distal Gastrectomy Withdrawn NCT00622804 Phase 3

Search NIH Clinical Center for Postgastrectomy Syndrome

Cochrane evidence based reviews: postgastrectomy syndromes

Genetic Tests for Postgastrectomy Syndrome

Anatomical Context for Postgastrectomy Syndrome

MalaCards organs/tissues related to Postgastrectomy Syndrome:

40
Testes, Small Intestine, Lymph Node, Liver, Pancreas, Thyroid

Publications for Postgastrectomy Syndrome

Articles related to Postgastrectomy Syndrome:

(show top 50) (show all 228)
# Title Authors PMID Year
1
Evaluation of postoperative quality of life by PGSAS-45 following local gastrectomy based on the sentinel lymph node concept in early gastric cancer. 61
32086650 2020
2
Comparison of Postoperative Quality of Life among Three Different Reconstruction Methods After Proximal Gastrectomy: Insights From the PGSAS Study. 61
32506229 2020
3
Delta-shaped anastomosis vs circular stapler anastomosis after laparoscopic distal gastrectomy with Billroth I reconstruction: A randomized controlled trial. 61
31814306 2019
4
Rikkunshito for upper gastrointestinal symptoms: A systematic review and meta-analysis. 61
30670250 2019
5
Background factors influencing postgastrectomy syndromes after various types of gastrectomy. 61
30613669 2018
6
Quality of life after proximal gastrectomy a review. 61
30441989 2018
7
Preservation of duodenal passage as a determinant of short- and long-term quality of life in gastric cancer patients after total gastrectomy. 61
28425683 2017
8
Predictive factors for body weight loss and its impact on quality of life following gastrectomy. 61
28765704 2017
9
Postgastrectomy Syndromes and Nutritional Considerations Following Gastric Surgery. 61
28325187 2017
10
Postoperative quality of life after laparoscopy-assisted pylorus-preserving gastrectomy compared With laparoscopy-assisted distal gastrectomy: A cross-sectional postal questionnaire survey. 61
27751530 2017
11
Quality of life after total vs distal gastrectomy with Roux-en-Y reconstruction: Use of the Postgastrectomy Syndrome Assessment Scale-45. 61
28373774 2017
12
Extreme dilatation of the interposed jejunal pouch after proximal gastrectomy associated with portal venous gas: A case report. 61
28715720 2017
13
Impaired Gastrointestinal Function Affects Symptoms and Alimentary Status in Patients After Gastrectomy. 61
27357933 2016
14
Factors affecting the quality of life of patients after gastrectomy as assessed using the newly developed PGSAS-45 scale: A nationwide multi-institutional study. 61
27833389 2016
15
Assessment of postoperative quality of life following pylorus-preserving gastrectomy and Billroth-I distal gastrectomy in gastric cancer patients: results of the nationwide postgastrectomy syndrome assessment study. 61
25637175 2016
16
Diminished Gastric Resection Preserves Better Quality of Life in Patients with Early Gastric Cancer. 61
27094837 2016
17
ASSESSMENT OF THE GASTRO-JEJUNO-DUODENAL TRANSIT AFTER JEJUNAL POUCH INTERPOSITION. 61
26734789 2015
18
[RESULTS OF GASTROPLASTY, USING ILEOCECAL SEGMENT OF INTESTINE AFTER COMBINED GASTRECTOMY]. 61
26939418 2015
19
Optimal Roux-en-Y reconstruction after distal gastrectomy for early gastric cancer as assessed using the newly developed PGSAS-45 scale. 61
25631461 2015
20
Evaluation of postgastrectomy symptoms after distal gastrectomy with Billroth-I reconstruction using the Postgastrectomy Syndrome Assessment Scale-45 (PGSAS-45). 61
25091080 2015
21
Factors that minimize postgastrectomy symptoms following pylorus-preserving gastrectomy: assessment using a newly developed scale (PGSAS-45). 61
24760336 2015
22
Long-term quality-of-life comparison of total gastrectomy and proximal gastrectomy by postgastrectomy syndrome assessment scale (PGSAS-45): a nationwide multi-institutional study. 61
24801198 2015
23
Characteristics and clinical relevance of postgastrectomy syndrome assessment scale (PGSAS)-45: newly developed integrated questionnaires for assessment of living status and quality of life in postgastrectomy patients. 61
24515247 2015
24
Assessment of motor function of the remnant stomach by ¹³C breath test with special reference to gastric local resection. 61
24934641 2014
25
Postgastrectomy Syndrome Assessment Scale (PGSAS)-45 and changes in body weight are useful tools for evaluation of reconstruction methods following distal gastrectomy. 61
24590434 2014
26
Roux-en-Y limb motility after total gastrectomy. 61
24496746 2014
27
[State of duodenal patency in patients with postgastrectomy syndromes]. 61
25042190 2014
28
Effects of rikkunshito, a kampo medicine, on quality of life after proximal gastrectomy. 61
23856127 2013
29
Endoscopic treatment of efferent loop syndrome with insertion of double pigtail stent. 61
24222968 2013
30
[Improving the quality of life after gastrectomy is the next issue after saving the lives of patients with gastric cancer]. 61
22413550 2012
31
[Postgastrectomy symptoms following total gastrectomy with or without preservation of the duodenal passage]. 61
22169340 2011
32
Postgastrectomy syndromes. 61
21889032 2011
33
[Postgastrectomy syndromes in therapeutic practice ]. 61
22416446 2011
34
[The Roux reconstruction for the correction of postresectional and postgastrectomy syndromes]. 61
22408798 2011
35
Improved long-term quality of life in patients with laparoscopy-assisted distal gastrectomy with jejunal pouch interposition for early gastric cancer. 61
20443144 2010
36
Gastric emptying function in patients 5 years after pylorus-preserving distal gastrectomy with or without preserving pyloric and hepatic branches of the vagal nerve for early gastric cancer. 61
19649759 2009
37
Functional evaluation after vagus-nerve-sparing laparoscopically assisted distal gastrectomy. 61
18594924 2008
38
Simultaneous dynamic study of gastric emptying and changes of serum levels of gut hormones in patients after peptic ulcer surgery. 61
16791805 2006
39
Pylorus-preserving gastrectomy in gastric cancer surgery--open and laparoscopic approaches. 61
16096761 2005
40
[Late follow-up of gastrectomized patients for peptic ulcer: clinical, endoscopic and histopathological aspects]. 61
16200249 2005
41
[Postgastrectomy syndrome and its management]. 61
15685879 2005
42
[Surgical treatment of diseases of operated stomach]. 61
16044124 2005
43
Postgastrectomy syndromes--diagnosis and treatment. 61
15494286 2004
44
Altered contractile responsiveness in ileal longitudinal muscle after total gastrectomy in a rat model. 61
14745614 2004
45
Pathophysiological studies on the relationship between postgastrectomy syndrome and gastric emptying function at 5 years after pylorus-preserving distal gastrectomy for early gastric cancer. 61
12734683 2003
46
New type of reconstruction method after subtotal gastrectomy (Noh's operation). 61
12715224 2003
47
Reconstruction after distal gastrectomy by interposition of a double-jejunal pouch using a triangulating stapling technique. 61
12658493 2003
48
Jejunal interposition to prevent postgastrectomy syndromes (Br J Surg 2000; 87: 1576-9). 61
11412275 2001
49
Jejunal interposition to prevent postgastrectomy syndromes. 61
11091248 2000
50
[Restoration of duodenal transit in the surgical treatment of postgastrectomy syndrome. The Soupault-Bucaille procedure]. 61
11140107 2000

Variations for Postgastrectomy Syndrome

Expression for Postgastrectomy Syndrome

Search GEO for disease gene expression data for Postgastrectomy Syndrome.

Pathways for Postgastrectomy Syndrome

GO Terms for Postgastrectomy Syndrome

Cellular components related to Postgastrectomy Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 SST PYY INS GIP GHRL GCG
2 extracellular region GO:0005576 9.61 SST PYY NTS MLN INS GIP
3 endoplasmic reticulum lumen GO:0005788 9.46 INS GIP GHRL GCG
4 secretory granule lumen GO:0034774 8.92 INS GIP GHRL GCG

Biological processes related to Postgastrectomy Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of insulin secretion GO:0050796 9.33 GIP GCG CACNA1E
2 G protein-coupled receptor signaling pathway GO:0007186 9.28 SST PYY NTS MLN INS GIP
3 response to acidic pH GO:0010447 9.26 SST GIP
4 polysaccharide digestion GO:0044245 8.96 SI MGAM

Molecular functions related to Postgastrectomy Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.23 SST PYY MLN INS GIP GHRL
2 neuropeptide hormone activity GO:0005184 9.16 PYY NTS
3 glucagon receptor binding GO:0031769 8.96 GIP GCG

Sources for Postgastrectomy Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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