Postherpetic Neuralgia

Categories: Neuronal diseases, Skin diseases

Aliases & Classifications for Postherpetic Neuralgia

MalaCards integrated aliases for Postherpetic Neuralgia:

Name: Postherpetic Neuralgia 54 37 72


External Ids:

KEGG 37 H01624
UMLS 72 C0032768

Summaries for Postherpetic Neuralgia

NINDS : 54 Shingles (herpes zoster) is an outbreak of rash or blisters on the skin that is caused by the same virus that causes chickenpox — the varicella-zoster virus. The first sign of shingles is often burning or tingling pain (which can be severe), or sometimes numbness or itch,generally on one side of the body. After several days or a week, a rash of fluid-filled blisters, similar to chickenpox, appears in one area on one side of the body. Shingles pain can be mild or intense.  Some people have mostly itching; some feel pain from the gentlest touch or breeze.  The most common location for shingles is a band, called a dermatome, spanning one side of the trunk around the waistline. Anyone who has had chickenpox is at risk for shingles.  Scientists think that some of the virus particles from the original exposure to the varicella-zoster virus,leave the skin blisters and move into the nervous system.  When the varicella-zoster virus reactivates, the virus moves back down the long nerve fibers that extend from the sensory cell bodies to the skin.  The viruses multiply, the tell-tale rash erupts, and the person now has shingles.

MalaCards based summary : Postherpetic Neuralgia is related to herpes zoster and graft-versus-host disease, and has symptoms including sciatica and neuralgia. An important gene associated with Postherpetic Neuralgia is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Cytokine Signaling in Immune system. The drugs Acyclovir and Foscarnet have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and brain.

KEGG : 37
Herpes zoster (HZ) presents as a rash of 2-3 weeks duration in immunocompetent patients that is accompanied by moderate or severe pain. In some patients, pain does not resolve when the rash heals but continues for weeks and, sometimes, for months or years; this phenomenon is known as postherpetic neuralgia (PHN). PHN is the most troublesome side effect associated with HZ. Both gabapentin and pregabalin can reduce pain and improve sleep patterns in patients with PHN.

Wikipedia : 75 Postherpetic neuralgia (PHN) is neuropathic pain which occurs due to damage to a peripheral nerve caused... more...

Related Diseases for Postherpetic Neuralgia

Diseases related to Postherpetic Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 herpes zoster 32.8 HLA-B HLA-A
2 graft-versus-host disease 29.0 HLA-DRB1 HLA-B HLA-A
3 exanthem 11.1
4 chickenpox 11.0
5 chronic pain 10.9
6 neuropathy 10.8
7 diabetic neuropathy 10.6
8 peripheral nervous system disease 10.6
9 trigeminal neuralgia 10.5
10 paresthesia 10.5
11 pain agnosia 10.4
12 herpes zoster ophthalmicus 10.4
13 polyneuropathy 10.4
14 neuromuscular disease 10.4
15 cytokine deficiency 10.4
16 myelitis 10.3
17 fibromyalgia 10.3
18 peptic ulcer disease 10.3
19 migraine with or without aura 1 10.2
20 anxiety 10.2
21 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.2
22 osteonecrosis 10.2
23 allergic hypersensitivity disease 10.2
24 diabetic polyneuropathy 10.2
25 personality disorder 10.2
26 mental depression 10.2
27 neuritis 10.2
28 constipation 10.2
29 complex regional pain syndrome 10.2
30 dystonia 10.2
31 herpes simplex 10.2
32 back pain 10.2
33 spasticity 10.2
34 spinal cord injury 10.2
35 echinococcosis 10.1 HLA-DRB1 HLA-B
36 atrial standstill 1 10.1
37 autoimmune disease 10.1
38 carpal tunnel syndrome 10.1
39 erythermalgia, primary 10.1
40 hemifacial spasm, familial 10.1
41 systemic lupus erythematosus 10.1
42 rheumatoid arthritis 10.1
43 spinal arachnoiditis 10.1
44 galactorrhea 10.1
45 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
46 ocular motor apraxia 10.1
47 paine syndrome 10.1
48 ataxia and polyneuropathy, adult-onset 10.1
49 helicobacter pylori infection 10.1
50 coronary heart disease 1 10.1

Graphical network of the top 20 diseases related to Postherpetic Neuralgia:

Diseases related to Postherpetic Neuralgia

Symptoms & Phenotypes for Postherpetic Neuralgia

UMLS symptoms related to Postherpetic Neuralgia:

sciatica, neuralgia

Drugs & Therapeutics for Postherpetic Neuralgia

DrugBank drugs 16 :

(show all 11)
# Drug Name Indication DrugBank ID
1 Capsaicin The capsaicin 8% patch is indicated in the treatment of neuropathic pain associated with post-herpetic neuralgia. There are multiple topical capsaicin formulations available, including creams and solutions, indicated for temporary analgesia in muscle and join pain as well as neuropathic pain. DB06774
2 Clonidine Clonidine tablets and transdermal systems are indicated for the treatment of hypertension alone or in combination with other medications.[L7237,L7240] A clonidine injection is indicated for use with opiates in the treatment of severe cancer pain where opiates alone are insufficient.[L7243] An extended release tablet of clonidine is indicated for the treatment of ADHD either alone or in combination with other medications.[L7246] Clonidine is also used for the diagnosis of pheochromocytoma,[A180565] treatment of nicotine dependance,[A180568] and opiate withdrawal.[A180571] DB00575
3 Desipramine For relief of symptoms in various depressive syndromes, especially endogenous depression. It has also been used to manage chronic peripheral neuropathic pain, as a second line agent for the management of anxiety disorders (e.g. panic disorder, generalized anxiety disorder), and as a second or third line agent in the ADHD management. DB01151
4 Gabapentin For the management of postherpetic neuralgia in adults and as adjunctive therapy in the treatment of partial seizures with and without secondary generalization in patients over 12 years of age with epilepsy. DB00996
5 Gabapentin enacarbil For the treatment of adult Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN). DB08872
6 Lidocaine Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks [F4349, L5930]. DB00281
7 Methotrimeprazine For the treatment of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. DB01403
8 Methyl salicylate Ointments or liniments containing methyl salicylate are applied topically as counter irritant for relief of acute pain associated with lumbago,sciatica and rheumatic conditions. Local analgesics for human and veterinary medicine. DB09543
9 Nortriptyline Primarily indicated for the relief of symptoms of depression. DB00540
10 Pregabalin Pregabalin is used for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, and as adjunctive therapy for adult patients with partial onset seizures [FDA label]. DB00230
11 Triamcinolone For the treatment of perennial and seasonal allergic rhinitis. DB00620

Drugs for Postherpetic Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 100)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Acyclovir Approved Phase 4 59277-89-3 2022
Foscarnet Approved Phase 4 63585-09-1, 4428-95-9 3415
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
Phosphonoacetic Acid Experimental Phase 4 4408-78-0 546
9 Reverse Transcriptase Inhibitors Phase 4
10 Anti-Retroviral Agents Phase 4
11 Anesthetics, Intravenous Phase 4
12 Anesthetics, Dissociative Phase 4
13 Anesthetics, General Phase 4
14 Analgesics, Non-Narcotic Phase 4
15 Cyclooxygenase Inhibitors Phase 4
16 Cyclooxygenase 2 Inhibitors Phase 4
17 Anti-Inflammatory Agents, Non-Steroidal Phase 4
18 diuretics Phase 4
19 Sodium Potassium Chloride Symporter Inhibitors Phase 4
20 Natriuretic Agents Phase 4
21 Anti-Infective Agents Phase 4
22 Antiviral Agents Phase 4
23 valacyclovir Phase 4
24 Excitatory Amino Acid Antagonists Phase 4
25 Excitatory Amino Acids Phase 4
26 Antimanic Agents Phase 4
Remifentanil Approved Phase 3 132875-61-7 60815
Triamcinolone Approved, Vet_approved Phase 2, Phase 3 124-94-7 31307
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
Sodium citrate Approved, Investigational Phase 3 68-04-2
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
Desipramine Approved, Investigational Phase 3 50-47-5 2995
Morphine Approved, Investigational Phase 3 57-27-2 5288826
Methadone Approved, Illicit Phase 3 76-99-3 4095
Nortriptyline Approved Phase 3 72-69-5 4543
Hydrocodone Approved, Illicit, Investigational Phase 3 125-29-1 5284569
Citric acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
38 triamcinolone acetonide Phase 2, Phase 3
39 Triamcinolone hexacetonide Phase 2, Phase 3
40 Triamcinolone diacetate Phase 2, Phase 3
41 Adrenergic Agents Phase 3
42 Anticoagulants Phase 3
43 Antidepressive Agents, Tricyclic Phase 3
44 Citrate Phase 3
45 Chelating Agents Phase 3
46 Adjuvants, Anesthesia Phase 3
47 Chlorpheniramine, phenylpropanolamine drug combination Phase 3
48 Respiratory System Agents Phase 3
49 Antitussive Agents Phase 3
Levetiracetam Approved, Investigational Phase 2 102767-28-2 441341

Interventional clinical trials:

(show top 50) (show all 130)
# Name Status NCT ID Phase Drugs
1 A Multi-centered, Randomized Study to Evaluate the Efficacy and Safety of Foscarnet Sodium and Sodium Chloride Injection Compared to Intravenous Acyclovir in Patients With Herpes Zoster From China Unknown status NCT02151240 Phase 4 Foscarnet Sodium;Acyclovir
2 An Enriched Enrollment, Double-Blind, Placebo-Controlled, Parallel Group, Randomized Withdrawal Trial to Evaluate the Efficacy, Tolerability and Safety of Etoricoxib (Arcoxia) in Patients With Moderate to Severe Neuropathic Pain Unknown status NCT01264237 Phase 4 Etoricoxib;Placebo
3 Lidocaine Patch for Postoperative Analgesia After Laparoscopic Cholecystectomy Unknown status NCT01485939 Phase 4
4 The Effect of Ketamine Infusion for Reduction of Neuropathic Pain and Improvement of Quality of Life After Lumbar Surgery Unknown status NCT02154438 Phase 4 Ketamine
5 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Unknown status NCT02535000 Phase 4 Duloxetine;Placebo
6 Effects of Pregabalin on Mechanical Hyperalgesia - EPOM Unknown status NCT00310583 Phase 4 Pregabalin
7 An 8-week Randomized, Double Blind, Multi-center, Placebo-controlled Study To Evaluate The Efficacy, Safety And Tolerability Of Pregabalin ( 300mg/Day ) Using A Fixed Dosing Schedule In The Treatment Of Subjects With Postherpetic Neuralgia ( Phn ) Completed NCT01455428 Phase 4 Lyrica (pregabalin);Placebo
8 A Prospective, Open-Label, Multicenter Study of the Effectiveness And Safety Of Lidoderm® As Add-On Treatment in Patients With Postherpetic Neuralgia, Diabetic Neuropathy, or Low Back Pain Completed NCT00904020 Phase 4 Lidoderm
9 Efficacy and Safety of Pregabalin in an Open-label, Non-comparative, Flexible-dose Trial With Diabetic Peripheral Neuropathy or Postherpetic Neuralgia Completed NCT00629681 Phase 4 Pregabalin
10 A Multicentre, Single-Arm, Open-Label Study Of The Repeated Administration Of QUTENZA For The Treatment Of Peripheral Neuropathic Pain Completed NCT01252160 Phase 4 QUTENZA
11 Randomized Placebo-Controlled Study of the Efficacy of Botulinum Toxin Type A (Botox) in Spontaneous Pain and Allodynia Related to Traumatic Nerve Injury or Postherpetic Neuralgia Completed NCT00527202 Phase 4 botulinum toxin A and saline
12 A Prospective, Open Label, Multi-Center, Study Of Pregabalin In The Treatment Of Neuropathic Pain Associated With Diabetic Peripheral Neuropathy, Postherpetic Neuralgia, HIV-Related Peripheral Neuropathic Pain And Chemotherapy Induced Peripheral Neuropathic Pain Completed NCT00407511 Phase 4 Pregabalin
13 Qutenza Versus Pregabalin in Subjects With Peripheral Neuropathic Pain: an Open-label, Randomized, Multicenter, Non-inferiority Efficacy and Tolerability Study Completed NCT01713426 Phase 4 Qutenza;Pregabalin
14 A Prospective, Randomized Study Evaluating the Efficacy and Safety of Early Diuresis Following Colorectal Surgery Completed NCT02351934 Phase 4 Furosemide;Celecoxib;Gabapentin
15 Randomized Double Blind Placebo Controlled Multicenter Study of the Efficacy and Safety of Repeated Administrations of Botulinum Toxin Type A (Botox) in the Treatment of Peripheral Neuropathic Pain Completed NCT01251211 Phase 4 botulinum toxin type A
16 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
17 Analgetic Effectiveness of Acupuncture When Compared to a Standardised Analgesic Regimen in the Treatment of Herpes Zoster Neuralgia Completed NCT00885586 Phase 4 gabapentine
18 The Effect of Epidural Steroid Use on Pain Relief in Patients With Continuous Epidural Nerve Block in Postherpetic Neuralgia Patients. Recruiting NCT03995563 Phase 4 Dexamethasone;Ropivacaine
19 Long-term Suppressive Valacyclovir Treatment for Herpes Zoster Ophthalmicus Recruiting NCT03134196 Phase 4 Masked Placebo;Masked Oral Valacyclovir
20 A Phase 4 Multicenter, Open-Label, Pilot Study Of Pregabalin And Prediction Of Treatment Response In Patients With Postherpetic Neuralgia Terminated NCT01603394 Phase 4 pregabalin
21 The Effect of Gabapentin on Postoperative Pain: a Randomized, Double Blind, Placebo Controlled Trial Terminated NCT01546857 Phase 4 Placebo;Gapabentin
22 Efficacy, Safety, Tolerability and Pharmacokinetics of Concomitant Administration of Tramadol With Duloxetine or Pregabalin: a Randomized Controlled Flexible-dose Study in Patients With Neuropathic Pain Withdrawn NCT01116531 Phase 4 Tramadol;Duloxetine;Pregabalin
23 Efficacy and Safety of Pregabalin Sustained Release Tablet for Postherpetic Neuralgia -A Multicenter,Randomized, Double-blind, Placebo-controlled Trial Unknown status NCT02868801 Phase 3 Placebo;Pregabalin SR tablet 165mg/day;Pregabalin SR tablet 330mg/day;Pregabalin SR tablet 660mg/day
24 Effect of Opioids in Neuropathic Pain in Postherpetic Patients Unknown status NCT01102101 Phase 3 Remifentanil
25 Prevention Effect of Pregabalin on Postherpetic Neuralgia: A Multicenter, Randomized, Double-blind, Controlled Trial Unknown status NCT03186443 Phase 3 Pregabalin;Gabapentin
26 Novel Non Invasive Brain Stimulation Based Treatment for Chronic Low Back Unknown status NCT02393391 Phase 2, Phase 3
27 A Phase 3 Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of Gabapentin Extended Release (G-ER) Tablets in the Treatment of Patients With Postherpetic Neuralgia Completed NCT00636636 Phase 3 Gabapentin Extended Release tablets;Placebo
28 A Long-Term Study To Evaluate Safety And Efficacy Of Pregabalin In The Treatment Of Postherpetic Neuralgia Completed NCT00424372 Phase 3 pregabalin
29 A Phase 3 Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of Gabapentin Extended Release (G-ER) Tablets in the Treatment of Patients With Postherpetic Neuralgia Completed NCT00335933 Phase 3 Gabapentin extended-release tablets
30 A Phase 2, Double Blind, Placebo Controlled, Dose-Ranging Study in Subjects With Postherpetic Neuralgia (PHN) to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Four Doses of TAK-583, Compared With Placebo Completed NCT00377598 Phase 2, Phase 3 TAK-583;TAK-583;TAK-583;TAK-583;Placebo
31 A 13-Week, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study To Evaluate Efficacy And Safety Of Pregabalin In The Treatment Of Postherpetic Neuralgia Completed NCT00394901 Phase 3 Placebo;Pregabalin;Pregabalin;Pregabalin
32 An 11-week Randomized, Double-blind, Multi Center, Placebo-controlled Study To Evaluate The Efficacy, Safety And Tolerability Of Pregabalin (300 Mg/Day) Using A Fixed Dosing Schedule In The Treatment Of Subjects S With Pain Associated With Diabetic Peripheral Neuropathy. Completed NCT01332149 Phase 3 Pregabalin;Placebo matched with pregabalin
33 A Multicenter Randomized, Double-Blind, Controlled Study of NGX-4010 for the Treatment of Postherpetic Neuralgia Completed NCT00300222 Phase 3 NGX-4010
34 A Randomized, Double-Blind, Controlled Study of NGX-4010 for the Treatment of Postherpetic Neuralgia Completed NCT00115310 Phase 3 NGX-4010
35 Safety and Efficacy of Lidocaine 5% Medicated Plaster in Comparison to Systemic Treatment in Postherpetic Neuralgia and Diabetic Polyneuropathic Pain. Completed NCT00414349 Phase 3 Topical analgesic;oral intake;Topical analgesic
36 A Randomized, Placebo-Controlled Trial of the Efficacy and Safety of Pregabalin in the Treatment of Subjects With Peripheral Neuropathic Pain Completed NCT00219544 Phase 3 Pregabalin (Lyrica);Pregabalin (Lyrica);Pregabalin (Lyrica);Placebo
37 A Phase 3 Double-blind, Randomized, Placebo-controlled, Safety And Efficacy Study Of Once Daily Controlled Release Pregabalin In The Treatment Of Patients With Postherpetic Neuralgia (Protocol A0081224) Completed NCT01270828 Phase 3 Pregabalin;placebo
38 A Randomized, Double-Blind, Controlled Study of NGX-4010 for the Treatment of Postherpetic Neuralgia Completed NCT00068081 Phase 3 Capsaicin Dermal Patch
39 A Multi-Center, Open-Label Extension Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of E2007 (Perampanel) in Patients With Painful Diabetic Neuropathy (PDN) or Post-Herpetic Neuralgia (PHN) Completed NCT00592904 Phase 2, Phase 3 E2007
40 A 12-Week Open-Label Study With 3 Within-Patient Double-Blind Placebo-Controlled Periods to Evaluate the Efficacy and Safety of OraVescent Fentanyl Citrate Treatment for the Management of Breakthrough Pain in Opioid-Tolerant Patients With Noncancer-Related Chronic Pain Completed NCT00343733 Phase 3 OraVescent Fentanyl
41 A Randomized, Double-Blind, Controlled Dose Finding Study of NGX-4010 for the Treatment of Postherpetic Neuralgia Completed NCT00061776 Phase 2, Phase 3 Capsaicin Dermal Patch
42 A Verification Study of JNS020QD in Patients With Post-herpetic Neuralgia, Complex Regional Pain Syndrome (CRPS) or Postoperative Pain Syndrome Completed NCT01008553 Phase 3 Fentanyl;Placebo
43 A Double-blind, Multicentre, Multiple-dose, Enriched Enrolment, Randomized-withdrawal, Parallel-group Phase III Study With Lido-Patch and Corresponding Placebo Plaster in Patients Suffering From Postherpetic Neuralgia (PHN) Completed NCT03745404 Phase 3 Lidocaine 5% medicated Plaster;Placebo Plaster
44 Phase III Randomized Controlled Study of Morphine and Nortriptyline in the Management of Postherpetic Neuralgia Completed NCT00004390 Phase 3 desipramine;methadone;morphine;nortriptyline
45 CSP #403 - Trial of Varicella Zoster Vaccine for the Prevention of Herpes Zoster and Its Complications Completed NCT00007501 Phase 3
46 A 12-Month, Open-Label Study to Evaluate the Long-Term Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) at 15 to 90 mg Every 12 Hours in Patients Who Require Opioid Treatment for an Extended Period of Time Completed NCT01223365 Phase 3 Hydrocodone ER
47 An Open-label, Multicenter, Multiple-dose, Phase III Study With Lidocaine 5% Medicated Plaster in Patients Suffering From Postherpetic Neuralgia Completed NCT03765697 Phase 3 Lidocaine 5% medicated plaster
48 A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study Evaluating the Efficacy and Tolerability of Oral SLC022 300 mg TID, a Glial Cell Modulating Agent, Versus Placebo in the Treatment of Post Herpetic Neuralgia Unknown status NCT00813826 Phase 2 SLC022;Placebo
49 Efficacy and Safety of Lidocaine Infusion Treatment in Management of Neuropathic Pain: Randomized, Controlled, Comparative Study Unknown status NCT02597257 Phase 2 Lidocaine HCl;Normal saline
50 Phase 2/3 Multi-Center, Double-Blind, Controlled Trial Comparing Topical ARYS-01 (Sorivudine) Cream 3%, Oral Valaciclovir, and Combination Topical ARYS-01 Cream /Oral Valaciclovir for Treatment of Herpes Zoster in Immunocompetent Patients 18 Years of Age or Older Unknown status NCT00652184 Phase 2 ARYS-01 (sorivudine) cream 3% or placebo cream;placebo;valaciclovir

Search NIH Clinical Center for Postherpetic Neuralgia

Inferred drug relations via UMLS 72 / NDF-RT 51 :

Gabapentin enacarbil
Methyl salicylate

Genetic Tests for Postherpetic Neuralgia

Anatomical Context for Postherpetic Neuralgia

MalaCards organs/tissues related to Postherpetic Neuralgia:

Skin, Spinal Cord, Brain, Testes, Dorsal Root Ganglion, Kidney, Eye

Publications for Postherpetic Neuralgia

Articles related to Postherpetic Neuralgia:

(show top 50) (show all 1891)
# Title Authors PMID Year
Suppression of neuropathic pain by selective silencing of dorsal root ganglion ectopia using nonblocking concentrations of lidocaine. 38
31095098 2019
A rare case of a gabapentin-induced cardiomyopathy. 38
30968430 2019
Transcutaneous Electrical Nerve Stimulation (TENS): a review of applications in dermatology. 38
31418608 2019
[Therapy of herpes zoster and postherpetic neuralgia]. 38
31270550 2019
Long-term effectiveness of zoster vaccine live for postherpetic neuralgia prevention. 38
31301920 2019
Mirogabalin for the management of postherpetic neuralgia: a randomized, double-blind, placebo-controlled phase 3 study in Asian patients: Erratum. 38
31335662 2019
Deep Sequencing Identification of Differentially Expressed miRNAs in the Spinal Cord of Resiniferatoxin-Treated Rats in Response to Electroacupuncture. 38
31124075 2019
A clinico-epidemiological multicenter study of herpes zoster in immunocompetent and immunocompromised hospitalized children. 38
31406693 2019
Relationships of varicella zoster virus (VZV)-specific cell-mediated immunity and persistence of VZV DNA in saliva and the development of postherpetic neuralgia in patients with herpes zoster. 38
31286531 2019
A Call for Caution in Prescribing Gabapentin to Individuals With Concurrent Polysubstance Abuse: A Case Report. 38
31291212 2019
Commentary on "A Call for Caution in Prescribing Gabapentin to Individuals with Concurrent Polysubstance Abuse: A Case Report". 38
31291213 2019
Effect of Recombinant Zoster Vaccine on Incidence of Herpes Zoster After Autologous Stem Cell Transplantation: A Randomized Clinical Trial. 38
31287523 2019
High-Voltage, Long-Duration Pulsed Radiofrequency on Gasserian Ganglion Improves Acute/Subacute Zoster-Related Trigeminal Neuralgia: A Randomized, Double-Blinded, Controlled Trial. 38
31337167 2019
A clinical study of paraspinal nerve block on treatment of herpes zoster under ultrasonic guidance. 38
31348920 2019
The efficacy of selective nerve root block for the long-term outcome of postherpetic neuralgia. 38
31257830 2019
Repetitive Transcranial Magnetic Stimulation at Different Frequencies for Postherpetic Neuralgia: A Double-Blind, Sham-Controlled, Randomized Trial. 38
31337172 2019
Public Health Impact and Cost-Effectiveness of Non-live Adjuvanted Recombinant Zoster Vaccine in Canadian Adults. 38
31250218 2019
Sleep Shortage Is Associated With Postherpetic Neuralgia Development Through Hyperesthesia and Acute Pain Intensity: A Community-Based Prospective Cohort Study. 38
30659740 2019
Population Pharmacokinetics of Pregabalin Extended-Release in Healthy Volunteers and Patients With Postherpetic Neuralgia, Fibromyalgia, and Partial-Onset Seizures. 38
31183879 2019
Attenuation of Unevoked Mechanical and Cold Pain Hypersensitivities Associated With Experimental Neuropathy in Mice by Angiotensin II Type-2 Receptor Antagonism. 38
31094778 2019
Neurological and Ophthalmological Manifestations of Varicella Zoster Virus. 38
30188405 2019
Incidence of herpes zoster and postherpetic neuralgia in Italian adults aged ≥50 years: A prospective study. 38
31193254 2019
Effects of Mindfulness-Based Stress Reduction on Depression, Anxiety, and Pain in Patients With Postherpetic Neuralgia. 38
31045954 2019
Antiviral Medications for the Prevention of Postherpetic Neuralgia After Herpes Zoster Infection. 38
30421565 2019
The Epidemiology of Herpes Zoster and Postherpetic Neuralgia in China: Results from a Cross-Sectional Study. 38
31218562 2019
Patient report of herpes zoster pain: Incremental benefits of zoster vaccine live. 38
31088744 2019
Corticosteroids for Preventing Postherpetic Neuralgia After Herpes Zoster Infection. 38
30421477 2019
The effects of repetitive transcranial magnetic stimulation on the whole-brain functional network of postherpetic neuralgia patients. 38
31232955 2019
Cost-Effectiveness of the Adjuvant Recombinant Zoster Vaccine in Japanese Adults Aged 65 Years and Older. 38
30929219 2019
Effect of pregabalin for the treatment of chronic refractory cough: A case report. 38
31169707 2019
A Clinical Overview of Off-label Use of Gabapentinoid Drugs. 38
30907944 2019
The comparative efficacy and safety of herpes zoster vaccines: A network meta-analysis. 38
30982636 2019
The Effect of Interventional Pain Management on Treating Postherpetic Neuralgia. 38
31148876 2019
Mirogabalin for the management of postherpetic neuralgia: a randomized, double-blind, placebo-controlled phase 3 study in Asian patients. 38
30913164 2019
Public health impact model estimating the impact of introducing an adjuvanted recombinant zoster vaccine into the UK universal mass vaccination programme. 38
31061027 2019
Interventional Treatments for Postherpetic Neuralgia: A Systematic Review. 38
31151330 2019
Patient-reported improvement in pain with pregabalin for painful diabetic neuropathy and postherpetic neuralgia is promising but needs further investigation. 38
31092541 2019
AAPT Diagnostic Criteria for Peripheral Neuropathic Pain: Focal and Segmental Disorders. 38
30527971 2019
Somatosensory profiles in acute herpes zoster and predictors of postherpetic neuralgia. 38
30585985 2019
Efficient induction of cell-mediated immunity to varicella-zoster virus glycoprotein E co-lyophilized with a cationic liposome-based adjuvant in mice. 38
30827737 2019
Herbal medicinal products or preparations for neuropathic pain. 38
30938843 2019
Effects of mirogabalin, a novel ligand for the α₂δ subunit of voltage-gated calcium channels, on N-type calcium channel currents of rat dorsal root ganglion culture neurons. 38
30961679 2019
Burden of Herpes Zoster in the Japanese Population with Immunocompromised/Chronic Disease Conditions: Results from a Cohort Study Claims Database from 2005-2014. 38
30456446 2019
Response to Transforaminal Epidural Block as a Useful Predictive Factor of Postherpetic Neuralgia. 38
30866567 2019
Epidemiology and clinical characteristics of herpes zoster in a tertiary care hospital in Brazil. 38
30935817 2019
Premedication With Gabapentin Significantly Reduces the Risk of Postherpetic Neuralgia in Patients With Neuropathy. 38
30718068 2019
ZTlido--a new lidocaine patch for postherpetic neuralgia. 38
31022155 2019
Acute pain and postherpetic neuralgia related to Varicella zoster virus reactivation: Comparison between typical herpes zoster and zoster sine herpete. 38
30179265 2019
The Economic Burden and Impact on Quality of Life of Herpes Zoster and Postherpetic Neuralgia in Individuals Aged 50 Years or Older in Italy. 38
30793003 2019
Herpes zoster and the risks of osteoporosis and fracture: a nationwide cohort study. 38
30460416 2019

Variations for Postherpetic Neuralgia

Expression for Postherpetic Neuralgia

Search GEO for disease gene expression data for Postherpetic Neuralgia.

Pathways for Postherpetic Neuralgia

Pathways related to Postherpetic Neuralgia according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
Show member pathways
Show member pathways
Show member pathways
12.04 HLA-B HLA-A
Show member pathways
7 11.93 HLA-B HLA-A
Show member pathways
9 11.83 HLA-B HLA-A
10 11.7 HLA-B HLA-A
11 11.67 HLA-DRB1 HLA-B HLA-A
12 11.61 HLA-B HLA-A
Show member pathways
11.51 HLA-DRB1 HLA-A
Show member pathways
11.47 HLA-DRB1 HLA-A
15 11.31 HLA-DRB1 HLA-B HLA-A
16 10.96 HLA-DRB1 HLA-B HLA-A
17 10.72 HLA-B HLA-A

GO Terms for Postherpetic Neuralgia

Cellular components related to Postherpetic Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.65 HLA-DRB1 HLA-B HLA-A
2 Golgi apparatus GO:0005794 9.63 HLA-DRB1 HLA-B HLA-A
3 cell surface GO:0009986 9.5 HLA-DRB1 HLA-B HLA-A
4 early endosome membrane GO:0031901 9.43 HLA-B HLA-A
5 Golgi membrane GO:0000139 9.43 HLA-DRB1 HLA-B HLA-A
6 recycling endosome membrane GO:0055038 9.4 HLA-B HLA-A
7 phagocytic vesicle membrane GO:0030670 9.37 HLA-B HLA-A
8 MHC class I protein complex GO:0042612 9.16 HLA-B HLA-A
9 ER to Golgi transport vesicle membrane GO:0012507 9.13 HLA-DRB1 HLA-B HLA-A
10 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.8 HLA-DRB1 HLA-B HLA-A

Biological processes related to Postherpetic Neuralgia according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.65 HLA-DRB1 HLA-B HLA-A
2 immune response GO:0006955 9.63 HLA-DRB1 HLA-B HLA-A
3 regulation of immune response GO:0050776 9.51 HLA-B HLA-A
4 type I interferon signaling pathway GO:0060337 9.49 HLA-B HLA-A
5 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.43 HLA-B HLA-A
6 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.4 HLA-B HLA-A
7 positive regulation of T cell mediated cytotoxicity GO:0001916 9.37 HLA-B HLA-A
8 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.32 HLA-B HLA-A
9 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.26 HLA-B HLA-A
10 protection from natural killer cell mediated cytotoxicity GO:0042270 9.16 HLA-B HLA-A
11 interferon-gamma-mediated signaling pathway GO:0060333 9.13 HLA-DRB1 HLA-B HLA-A
12 antigen processing and presentation GO:0019882 8.8 HLA-DRB1 HLA-B HLA-A

Molecular functions related to Postherpetic Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.8 HLA-DRB1 HLA-B HLA-A

Sources for Postherpetic Neuralgia

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
71 Tocris
73 UMLS via Orphanet
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