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MCID: PST021
MIFTS: 55

Postpartum Depression

Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Postpartum Depression

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MalaCards integrated aliases for Postpartum Depression:

Name: Postpartum Depression 12 43 15
Depression, Postpartum 44 73
Maternity Blues 12 73
Post-Partum Depression 76
Depression Postpartum 55
Postnatal Depression 12

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:9478
ICD10 33 F53
MeSH 44 D019052
NCIt 50 C92852
SNOMED-CT 68 58703003
Sources

Summaries for Postpartum Depression

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MedlinePlus : 43 Many women have the baby blues after childbirth. If you have the baby blues, you may have mood swings, feel sad, anxious or overwhelmed, have crying spells, lose your appetite, or have trouble sleeping. The baby blues most often go away within a few days or a week. The symptoms are not severe and do not need treatment. The symptoms of postpartum depression last longer and are more severe. You may also feel hopeless and worthless, and lose interest in the baby. You may have thoughts of hurting yourself or the baby. Very rarely, new mothers develop something even more serious. They may have hallucinations or try to hurt themselves or the baby. They need to get treatment right away, often in the hospital. Postpartum depression can begin anytime within the first year after childbirth. The cause is not known. Hormonal and physical changes after birth and the stress of caring for a new baby may play a role. Women who have had depression are at higher risk. If you think you have postpartum depression, tell your health care provider. Medicines, including antidepressants and talk therapy can help you get well. Dept. of Health and Human Services Office on Women's Health

MalaCards based summary : Postpartum Depression, also known as depression, postpartum, is related to depression and anxiety, and has symptoms including pelvic pain and mental and behavioral signs and symptoms. An important gene associated with Postpartum Depression is CRH (Corticotropin Releasing Hormone), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Phenylalanine metabolism. The drugs Estradiol valerate and Copper have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and thyroid, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Disease Ontology : 12 An endogenous depression that involves intense, sustained and sometimes disabling depression experienced by women after giving birth.

Wikipedia : 76 Postpartum depression (PPD), also called postnatal depression, is a type of mood disorder associated... more...

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Related Diseases for Postpartum Depression

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Diseases related to Postpartum Depression via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 depression 32.7 BDNF CRH MAOA SLC6A4
2 anxiety 30.3 BDNF COMT CRH MAOA OXT SLC6A4
3 premenstrual tension 30.1 CRH OXT PRL
4 alexithymia 30.0 COMT OXTR SLC6A4
5 pain agnosia 29.8 IER3IP1 OXT
6 personality disorder 29.8 BDNF COMT MAOA PRL SLC6A4
7 generalized anxiety disorder 29.7 BDNF COMT MAOA SLC6A4
8 bulimia nervosa 29.7 BDNF COMT SLC6A4
9 panic disorder 29.7 BDNF COMT CRH MAOA SLC6A4
10 trigeminal neuralgia 29.7 ESR1 SLC6A4
11 schizophrenia 29.6 BDNF COMT MAOA PRL SLC6A4
12 sudden infant death syndrome 29.6 BDNF MAOA SLC6A4
13 bipolar disorder 29.5 BDNF COMT CRH MAOA PRL SLC6A4
14 borderline personality disorder 29.5 BDNF COMT MAOA SLC6A4
15 conduct disorder 29.4 COMT MAOA OXTR SLC6A4
16 mood disorder 29.3 BDNF COMT CRH MAOA SLC6A4
17 autism 29.1 BDNF COMT MAOA OXT OXTR SLC6A4
18 major depressive disorder 29.0 BDNF COMT CRH MAOA OXT OXTR
19 disease of mental health 29.0 BDNF COMT CRH IER3IP1 MAOA OXT
20 obsessive-compulsive disorder 28.8 BDNF COMT CRH MAOA OXT OXTR
21 pedophilia 10.2 OXT PRL
22 hypothalamic disease 10.2 CRH PRL
23 pituitary carcinoma 10.2 CRH PRL
24 nelson syndrome 10.2 CRH PRL
25 sheehan syndrome 10.2 CRH PRL
26 schizophreniform disorder 10.2 COMT PRL
27 acth-secreting pituitary adenoma 10.2 CRH PRL
28 spinocerebellar degeneration 10.2 CRH PRL
29 premature ejaculation 10.2 COMT SLC6A4
30 intermittent explosive disorder 10.2 PRL SLC6A4
31 avoidant personality disorder 10.2 MAOA SLC6A4
32 sexual disorder 10.2 OXT PRL SLC6A4
33 dysthymic disorder 10.2 MAOA SLC6A4
34 kleptomania 10.1 MAOA SLC6A4
35 phobia, specific 10.1 COMT MAOA
36 alcohol abuse 10.1 BDNF PRL SLC6A4
37 drug dependence 10.1 BDNF CRH SLC6A4
38 pathological gambling 10.1 MAOA SLC6A4
39 bipolar i disorder 10.1 BDNF COMT SLC6A4
40 hypothyroidism, congenital, nongoitrous, 4 10.1 CRH PRL TPO
41 adrenal cortex disease 10.1 CRH PRL
42 agoraphobia 10.1 MAOA SLC6A4
43 social phobia 10.1 MAOA PRL SLC6A4
44 separation anxiety disorder 10.1 OXT OXTR PRL
45 postmenopausal atrophic vaginitis 10.1 ESR1 OXT
46 traumatic brain injury 10.1 BDNF COMT
47 atypical depressive disorder 10.1 CRH MAOA SLC6A4
48 estrogen excess 10.1 ESR1 PRL
49 serotonin syndrome 10.1 MAOA OXT SLC6A4
50 paraphilia disorder 10.1 MAOA OXT PRL

Graphical network of the top 20 diseases related to Postpartum Depression:



Diseases related to Postpartum Depression
Sources

Symptoms & Phenotypes for Postpartum Depression

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UMLS symptoms related to Postpartum Depression:


pelvic pain, mental and behavioral signs and symptoms

MGI Mouse Phenotypes related to Postpartum Depression:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 BDNF COMT CRH ESR1 HSD11B1 MAOA
2 endocrine/exocrine gland MP:0005379 9.96 BDNF COMT CRH ESR1 HSD11B1 OXT
3 homeostasis/metabolism MP:0005376 9.85 BDNF COMT CRH ESR1 HSD11B1 MAOA
4 integument MP:0010771 9.56 BDNF CRH ESR1 HSD11B1 OXT OXTR
5 nervous system MP:0003631 9.32 BDNF COMT CRH ESR1 HSD11B1 MAOA
Sources

Drugs & Therapeutics for Postpartum Depression

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Drugs for Postpartum Depression (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 238)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 979-32-8
2
Copper Approved, Investigational Phase 4,Phase 3 7440-50-8 27099
3
Norethindrone Approved Phase 4 68-22-4 6230
4
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 50-28-2 5757
5
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
6
Polyestradiol phosphate Approved Phase 4,Phase 2,Not Applicable 28014-46-2
7
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
8
Fluvoxamine Approved, Investigational Phase 4 54739-18-3 3404 5324346
9
Sertraline Approved Phase 4,Phase 3,Phase 2,Not Applicable 79617-96-2 68617
10
Norepinephrine Approved Phase 4,Phase 3,Not Applicable 51-41-2 439260
11
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
12
Citalopram Approved Phase 4,Not Applicable 59729-33-8 2771
13
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Not Applicable 84057-95-4 175805 71273
14
Oxytocin Approved, Vet_approved Phase 4,Phase 2,Not Applicable 50-56-6 439302 53477758
15
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
16
Calcium Carbonate Approved, Investigational Phase 4 471-34-1
17
Medroxyprogesterone acetate Approved, Investigational Phase 4 71-58-9
18
Iron Approved Phase 4,Phase 3,Phase 2,Not Applicable 7439-89-6 23925
19
Hydroxocobalamin Approved Phase 4,Phase 2,Phase 3 13422-51-0 11953898 44475014
20
Methylcobalamin Approved, Experimental, Investigational Phase 4,Phase 2,Phase 3 13422-55-4
21
leucovorin Approved Phase 4,Phase 2,Phase 3 58-05-9 6006 143
22
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 57-27-2 5288826
23
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
24
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
25
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
26
Carbetocin Approved, Investigational Phase 4 37025-55-1 71715 16681432
27
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
28
Cyanocobalamin Approved, Nutraceutical Phase 4,Phase 2,Phase 3 68-19-9 44176380
29
Cobalamin Experimental Phase 4,Phase 2,Phase 3 13408-78-1 6438156
30 Contraceptives, Oral Phase 4,Not Applicable
31 Spermatocidal Agents Phase 4
32 Hormones Phase 4,Phase 2,Not Applicable
33 Hormone Antagonists Phase 4,Phase 2,Not Applicable
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Not Applicable
35 Contraceptive Agents Phase 4,Phase 2,Not Applicable
36 Estrogens Phase 4,Phase 2,Not Applicable
37 Estradiol 3-benzoate Phase 4,Phase 2,Not Applicable
38 Norethindrone acetate Phase 4
39 Estradiol 17 beta-cypionate Phase 4,Phase 2,Not Applicable
40 Venlafaxine Hydrochloride Phase 4
41 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
42 Antidepressive Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
43 Serotonin Uptake Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
44 Duloxetine Hydrochloride Phase 4,Not Applicable
45 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4,Phase 3,Not Applicable
46 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
47 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable
48 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
49 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
50 Serotonin Agents Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 396)
# Name Status NCT ID Phase Drugs
1 Oral Contraceptive Ethinyl Estradiol Dose Effect on Postpartum Depression and Sexual Functioning Scales Unknown status NCT02210702 Phase 4 Ethinyl Estradiol 35mcg/Norethindrone 1mg;Ethinyl Estradiol 20mcg/Norethindrone 1mg
2 The Influence of Antenatal Classes on Pregnancy, Birth and Parenthood Unknown status NCT00323401 Phase 4
3 Antidepressants During Pregnancy and Lactation: Pharmacokinetics and Clinical Implications Unknown status NCT01796132 Phase 4 SSRI/SNRI
4 Low-dose Ketamine and Postpartum Depression in Parturients With Prenatal Depression Completed NCT03336541 Phase 4 Ketamine;Placebo
5 Escitalopram (Lexapro) for the Treatment of Postpartum Depression Completed NCT00833469 Phase 4 Escitalopram
6 Effectiveness of Supplemental Calcium in Preventing Postpartum Depression Completed NCT00228033 Phase 4 Elemental calcium (as carbonate)
7 Timing of Postpartum Depot Medroxyprogesterone Acetate Administration on Breastfeeding, Contraceptive Continuation, and Depression Completed NCT01463202 Phase 4 Depot medroxyprogesterone acetate;Depot medroxyprogesterone acetate
8 Vitamin B12 Pregnancy Supplementation Completed NCT03522428 Phase 4
9 NEOBIFI: Clinical Trial for the Prevention and/or Reduction of the Incidence of Colics in Infants Completed NCT03219931 Phase 4 Bifidobacterium breve BR03 and Bifidobacterium breve B632;Placebos
10 Effect of Tramadol in Prevention of Postpartum Depression Recruiting NCT03309163 Phase 4 Tramadol;Hydromorphone;Ropivacaine (Epidural analgesia)
11 Postpartum Perineal Pain After Obstetric Anal Sphincter Injuries Recruiting NCT03470675 Phase 4 Epidural saline + IV saline;Epidural morphine 3 mg + IV saline;Epidural morphine 3 mg + IV ketamine 0.3 mg/kg
12 Impact of Local Anesthetic Wound Infiltration on Postoperative Pain Following Cesarean Delivery Recruiting NCT02829944 Phase 4 Ropivacaine;Ketorolac;Placebo
13 Vaginal Estrogen on Postpartum Atrophy, Perineal Pain, and Sexual Function Recruiting NCT03493126 Phase 4 Estradiol
14 Effect of Dexmedetomidine on Parturient Undergoing Elective Cesarean Section. Not yet recruiting NCT03805945 Phase 4 high dose dexmedetomidine group;medium dose dexmedetomidine group;low dose dexmedetomidine group;control group
15 Effect of the Uterotonic Carbetocin on Acute Post Cesarean-Section Pain Not yet recruiting NCT02642263 Phase 4 Carbetocin
16 Oxytocin Dosing at Planned Cesarean Section and Anemia Not yet recruiting NCT03361124 Phase 4 Oxytocin
17 Postpartum Depression: Transdermal Estradiol Versus Sertraline Terminated NCT00744328 Phase 4 Transdermal Estradiol;Sertraline
18 Outcome of Postnatal Depression Screening Using Edinburgh Postnatal Depression Scale Unknown status NCT00251342 Phase 2, Phase 3
19 Postoperative Analgesia After Caesarean Section Under ALR: TAP Block Versus Catheter Scar Infiltration Unknown status NCT02184559 Phase 3 Ropivacaine
20 A Randomized Trial of Docosahexaenoic Acid Supplementation During Pregnancy to Prevent Deep Placentation Disorders Unknown status NCT02336243 Phase 3
21 Aripiprazole and Resistant Postpartum Depression Completed NCT01386086 Phase 3 aripiprazole
22 A Study to Evaluate SAGE-217 in Subjects With Severe Postpartum Depression Completed NCT02978326 Phase 3 SAGE-217;Placebo
23 A Study to Evaluate SAGE-547 in Patients With Severe Postpartum Depression Completed NCT02942004 Phase 3 SAGE-547;Placebo
24 A Study to Evaluate SAGE-547 in Patients With Moderate Postpartum Depression Completed NCT02942017 Phase 3 SAGE-547;Placebo
25 Identification and Therapy of Postpartum Depression Completed NCT00282776 Phase 3
26 Sertraline for the Prevention of Recurrent Postpartum Depression Completed NCT00276900 Phase 3 Sertraline
27 Functional Outcome in Postpartum Depression in Women Treated With Desvenlafaxine Completed NCT01527786 Phase 3 Desvenlafaxine
28 A Randomised Trial of Sertraline, Cognitive Behaviour Therapy & Combined Therapy for Postnatal Depression Completed NCT02122393 Phase 3 Sertraline
29 Effect of the 'Mother and Baby' Program on Well-Being Completed NCT00361478 Phase 3
30 Mother-Infant Psychoanalysis Project of Stockholm Completed NCT00923559 Phase 3
31 Does Fish Oil Prevent Depression in Pregnancy and Postpartum? Completed NCT00711971 Phase 2, Phase 3 EPA-rich fish oil supplement;DHA-rich fish oil supplement;placebo
32 Improving Health Outcomes for New Mothers and Babies Completed NCT00360204 Phase 3
33 Gestational Diabetes: Insulin or Oral Hypoglycemic Agents? Completed NCT01215331 Phase 3 Insulin;Metformin, glyburide and insulin
34 Vitamin B12 Supplementation During Pregnancy Completed NCT01795131 Phase 2, Phase 3
35 Treatment of Women After Severe Postpartum Haemorrhage Completed NCT01895205 Phase 3 Iron isomaltoside 1000;Red blood cell transfusion
36 Treatment of Women After Postpartum Haemorrhage Completed NCT01895218 Phase 3 Iron isomaltoside 1000
37 Hypnosis Antenatal Training for Childbirth (HATCh): a Randomised Controlled Trial Completed NCT00282204 Phase 2, Phase 3
38 The Synchronized Trial on Expectant Mothers With Depressive Symptoms by Omega-3 PUFAs (SYNCHRO) Completed NCT02166424 Phase 3
39 Adjunctive Use of Celecoxib in the Treatment of Bipolar Postpartum Depression Recruiting NCT02726659 Phase 3 Celecoxib;Placebo
40 A Study to Assess the Safety and Efficacy of Brexanolone in the Treatment of Adolescent Female Subjects With Postpartum Depression Recruiting NCT03665038 Phase 3 Brexanolone;Placebo
41 CODEPAD (Collaborative Outcomes of DEpression and Pain Associated With Delivery) Recruiting NCT03167905 Phase 2, Phase 3 Entonox;Meperidine;Ultiva;Fentanyl;Ropivacaine
42 ITM + Bupivacaine QLB vs. ITM + Sham Saline QLB for Cesarean Delivery Pain Recruiting NCT03261193 Phase 3 ITM + Sham QLB;ITM + Bupivacaine QLB
43 Impact of Pre-pregnancy Micronutrient Supplementation on Maternal and Child Outcomes Active, not recruiting NCT01665378 Phase 3
44 Dolutegravir in Pregnant HIV Mothers and Their Neonates Active, not recruiting NCT03249181 Phase 3 Dolutegravir;Standard of Care (EFV + 2 NRTI backbone)
45 Oral Probiotic Supplementation in Pregnancy to Reduce Group B Streptococcus Colonization Not yet recruiting NCT03407157 Phase 3
46 Controlled Randomised Trial of Ferric Carboxymaltose and Oral Iron to Treat Postpartum Anemia Terminated NCT00929409 Phase 2, Phase 3 Ferric carboxymaltose;Ferrous sulfate tablets
47 A Phase III Efficacy and Safety Study of Intravenous Retosiban Versus Placebo for Women in Spontaneous Preterm Labor Terminated NCT02377466 Phase 3 Retosiban IV infusion;Placebo IV infusion
48 Pilot Trial of CenteringPregnancy With Mindfulness Skills Unknown status NCT01646463 Phase 1, Phase 2
49 Mom: Managing Our Mood, Part of The Family Help Program Completed NCT00795652 Phase 2
50 Evaluate SAGE-547 in Female Patients With Severe Postpartum Depression Completed NCT02285504 Phase 2 SAGE-547

Search NIH Clinical Center for Postpartum Depression

Cochrane evidence based reviews: depression, postpartum

Sources

Genetic Tests for Postpartum Depression

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Sources

Anatomical Context for Postpartum Depression

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MalaCards organs/tissues related to Postpartum Depression:

41
Testes, Skin, Thyroid, Brain, Pituitary, T Cells, Cortex
Sources

Publications for Postpartum Depression

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Articles related to Postpartum Depression:

(show top 50) (show all 1093)
# Title Authors Year
1
Associations between broader autism phenotype (BAP) and maternal attachment are moderated by maternal postpartum depression when infants are one month old: A prospective study of the Japan environment & children's study. ( 30273887 )
2019
2
History of postpartum depression as a contributor to the severity of NAS. ( 30268061 )
2019
3
'Happy that someone cared'-Non-native-speaking immigrant mothers' experiences of participating in screening for postpartum depression in the Swedish child health services. ( 29804463 )
2018
4
Relationship Between Postpartum Depression and Psychological and Biological Variables in the Initial Postpartum Period. ( 29423586 )
2018
5
Postpartum Depression and Its Long-term Impact on Children: Many New Questions. ( 29387871 )
2018
6
Passive smoking and postpartum depression among Chinese women: a prospective cohort study in Tianjin, China. ( 29924720 )
2018
7
Integrating Optimal Screening, Intervention, and Referral for Postpartum Depression in Adolescents. ( 29779510 )
2018
8
Preliminary Psychometric Testing of the Postpartum Depression Predictors Inventory-Revised (PDPI-R) in Portuguese Women. ( 29327321 )
2018
9
The role of tryptophan metabolism in postpartum depression. ( 29307018 )
2018
10
Screening for Postpartum Depression in American Indian/Alaska Native Women: A Comparison of Two Instruments. ( 29889949 )
2018
11
Subconstructs of the Edinburgh Postpartum Depression Scale in a postpartum sample in Mexico City. ( 29879609 )
2018
12
Mastery, self-esteem, and optimism mediate the link between religiousness and spirituality and postpartum depression. ( 29855845 )
2018
13
Adverse Childhood Experiences and Postpartum Depression in Home Visiting Programs: Prevalence, Association, and Mediating Mechanisms. ( 29435785 )
2018
14
Postpartum depression in older women. ( 29401116 )
2018
15
Association between intrapartum epidural use and maternal postpartum depression presenting for medical care: a population-based, matched cohort study. ( 29954649 )
2018
16
Postpartum depression and vitamin D: A systematic review. ( 29393662 )
2018
17
Effectiveness of acupuncture in postpartum depression: a systematic review and meta-analysis. ( 29907576 )
2018
18
Prevalence and factors associated with postpartum depression in women from single-child families. ( 29412451 )
2018
19
Rationale, design, and baseline data for the Healthy Mom II Trial: A randomized trial examining the efficacy of exercise and wellness interventions for the prevention of postpartum depression. ( 29747048 )
2018
20
Injection of oxytocin into paraventricular nucleus reverses depressive-like behaviors in the postpartum depression rat model. ( 28889022 )
2018
21
An analysis of whether sleep disorder will result in postpartum depression. ( 29861873 )
2018
22
Anaemia and depletion of iron stores as risk factors for postpartum depression: a literature review. ( 29363366 )
2018
23
Risk factors for positive postpartum depression screen in women with private health insurance and access to care. ( 29852802 )
2018
24
Commentary on "Improvement of postpartum depression and psychosis after electroconvulsive therapy - A population-based study with a matched comparison group". ( 29908473 )
2018
25
The effectiveness of exercise-based interventions for preventing or treating postpartum depression: a systematic review and meta-analysis. ( 29882074 )
2018
26
Adverse childhood experiences and intimate partner violence during pregnancy and their association to postpartum depression. ( 29310065 )
2018
27
Gene expression profile in peripheral blood mononuclear cells of postpartum depression patients. ( 29973662 )
2018
28
Thyroid peroxidase antibodies during early gestation and the subsequent risk of first-onset postpartum depression: A prospective cohort study. ( 28850854 )
2018
29
Digital Peer-Support Platform (7Cups) as an Adjunct Treatment for Women With Postpartum Depression: Feasibility, Acceptability, and Preliminary Efficacy Study. ( 29439944 )
2018
30
Perinatal Nurses' and Midwives' Knowledge About Assessment and Management of Postpartum Depression. ( 29916523 )
2018
31
Coping strategies of women with postpartum depression symptoms in rural Ethiopia: a cross-sectional community study. ( 29422037 )
2018
32
Developing a Postpartum Depression Screening and Referral Procedure in Pediatric Primary Care. ( 29305113 )
2018
33
Postpartum depression and social support in a racially and ethnically diverse population of women. ( 29968129 )
2018
34
Peer-support intervention for postpartum depression: Participant satisfaction and program effectiveness. ( 29908406 )
2018
35
Comments on: insomnia, postpartum depression and estradiol in women after delivery. ( 29340844 )
2018
36
Postpartum depression and resilience predict parenting sense of competence in women with childhood maltreatment history. ( 29860623 )
2018
37
Anxiety During Pregnancy and Postpartum: Course, Predictors and Comorbidity with Postpartum Depression. ( 30256010 )
2018
38
Association Between Antenatal and Postpartum Depression and Anxiety with Weight Retention 1 Year After Childbirth: A Longitudinal Study. ( 30140991 )
2018
39
Risk of Postpartum Depression Among Women with Asthma. ( 30292921 )
2018
40
Should all women with postpartum depression be screened for bipolar disorder? ( 30037609 )
2018
41
Are Mixed Symptoms a Red Flag for Conversion of Postpartum Depression to Bipolar Disorder? ( 29722935 )
2018
42
Postpartum Depression in Mothers of Infants With Cleft Lip and/or Palate. ( 29481498 )
2018
43
Pathophysiological Mechanisms Implicated in Postpartum Depression. ( 30552910 )
2018
44
The maternal reward system in postpartum depression. ( 30554286 )
2018
45
A Novel, Synthetic, Neuroactive Steroid Is Effective at Decreasing Depression-Like Behaviors and Improving Maternal Care in Preclinical Models of Postpartum Depression. ( 30532739 )
2018
46
Barriers to postpartum depression treatment among Indigenous Bedouin women in Israel: A focus group study. ( 30488992 )
2018
47
Mothers' Mental Health Care Utilization After Screening for Postpartum Depression at Well Child Visits. ( 30496869 )
2018
48
Predictive validity of the Postpartum Depression Predictors Inventory-Revised (PDPI-R): A longitudinal study with Portuguese women. ( 30496938 )
2018
49
PPD ACT: an app-based genetic study of postpartum depression. ( 30498212 )
2018
50
An exploratory study of the effect of labor pain management on postpartum depression among Chinese women. ( 30508215 )
2018
Sources

Variations for Postpartum Depression

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Sources

Expression for Postpartum Depression

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Search GEO for disease gene expression data for Postpartum Depression.
Sources

Pathways for Postpartum Depression

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Pathways related to Postpartum Depression according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.76 BDNF MAOA SLC6A4
2
Phenylalanine metabolism 37
Show member pathways
 11.02 COMT MAOA TPO
3
Prostaglandin Synthesis and Regulation 1
10.91 HSD11B1 PRL
4
Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics 61
10.85 MAOA SLC6A4
5
Biogenic Amine Synthesis 1
Show member pathways
 10.66 COMT MAOA
6
noradrenaline and adrenaline degradation 1
Show member pathways
 10.43 COMT MAOA
7
Dopamine metabolism 1
10.3 COMT MAOA
8
Neurotransmitter Clearance In The Synaptic Cleft 66
Show member pathways
 10.21 COMT MAOA SLC6A4
Sources

GO Terms for Postpartum Depression

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Biological processes related to Postpartum Depression according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 9.8 ESR1 OXT OXTR
2 response to estrogen GO:0043627 9.72 COMT CRH ESR1
3 response to drug GO:0042493 9.72 COMT CRH OXTR PRL SLC6A4
4 positive regulation of synapse assembly GO:0051965 9.71 BDNF OXT OXTR
5 social behavior GO:0035176 9.67 OXT OXTR SLC6A4
6 response to organic cyclic compound GO:0014070 9.67 COMT OXT OXTR PRL
7 response to progesterone GO:0032570 9.65 OXT OXTR
8 response to amphetamine GO:0001975 9.65 OXT OXTR
9 regulation of sensory perception of pain GO:0051930 9.64 COMT OXT
10 response to steroid hormone GO:0048545 9.64 OXT OXTR
11 eating behavior GO:0042755 9.63 OXT OXTR
12 positive regulation of blood pressure GO:0045777 9.62 OXT OXTR
13 response to pain GO:0048265 9.62 COMT CRH
14 maternal behavior GO:0042711 9.61 OXT OXTR
15 parturition GO:0007567 9.61 CRH PRL
16 response to cocaine GO:0042220 9.61 CRH OXT OXTR
17 sleep GO:0030431 9.6 OXT OXTR
18 catecholamine metabolic process GO:0006584 9.59 COMT MAOA
19 glucocorticoid biosynthetic process GO:0006704 9.58 CRH HSD11B1
20 neurotransmitter catabolic process GO:0042135 9.58 COMT MAOA
21 dopamine catabolic process GO:0042420 9.57 COMT MAOA
22 positive regulation of uterine smooth muscle contraction GO:0070474 9.56 OXT OXTR
23 memory GO:0007613 9.56 BDNF OXT OXTR SLC6A4
24 negative regulation of gastric acid secretion GO:0060455 9.52 OXT OXTR
25 positive regulation of penile erection GO:0060406 9.51 OXT OXTR
26 positive regulation of norepinephrine secretion GO:0010701 9.48 OXT OXTR
27 response to ether GO:0045472 9.46 CRH OXT
28 regulation of digestive system process GO:0044058 9.4 OXT OXTR
29 response to estradiol GO:0032355 9.35 ESR1 OXT OXTR PRL SLC6A4
30 sperm ejaculation GO:0042713 9.33 OXT OXTR SLC6A4
31 female pregnancy GO:0007565 9.02 COMT CRH OXT OXTR PRL

Molecular functions related to Postpartum Depression according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 9.16 ESR1 HSD11B1
2 neuropeptide hormone activity GO:0005184 8.96 CRH OXT
3 hormone activity GO:0005179 8.8 CRH OXT PRL
Sources

Sources for Postpartum Depression

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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