MCID: PST103
MIFTS: 33

Postpartum Psychosis

Categories: Rare diseases, Reproductive diseases

Aliases & Classifications for Postpartum Psychosis

MalaCards integrated aliases for Postpartum Psychosis:

Name: Postpartum Psychosis 59 72
Puerperal Psychosis 59

Characteristics:

Orphanet epidemiological data:

59
postpartum psychosis
Inheritance: Not applicable;

Classifications:



External Ids:

ICD10 via Orphanet 34 F53.1
UMLS via Orphanet 73 C0520678
Orphanet 59 ORPHA443173
UMLS 72 C0520678

Summaries for Postpartum Psychosis

MalaCards based summary : Postpartum Psychosis, also known as puerperal psychosis, is related to carbamoyl phosphate synthetase i deficiency, hyperammonemia due to and citrullinemia, classic. An important gene associated with Postpartum Psychosis is ASS1 (Argininosuccinate Synthase 1), and among its related pathways/superpathways are Carbon metabolism and Amino Acid metabolism. The drugs Estradiol and Polyestradiol phosphate have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and breast.

Wikipedia : 75 Postpartum psychosis is a rare psychiatric emergency in which symptoms of high mood and racing thoughts... more...

Related Diseases for Postpartum Psychosis

Diseases related to Postpartum Psychosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 carbamoyl phosphate synthetase i deficiency, hyperammonemia due to 29.6 OTC ASS1
2 citrullinemia, classic 29.6 OTC ASS1
3 carbonic anhydrase va deficiency, hyperammonemia due to 29.6 OTC ASS1
4 urea cycle disorder 29.5 OTC ASS1
5 argininosuccinic aciduria 29.2 OTC ASS1
6 major affective disorder 8 10.5
7 major affective disorder 9 10.5
8 bipolar disorder 10.5
9 mood disorder 10.3
10 psychotic disorder 10.3
11 encephalitis 10.2
12 mental depression 10.1
13 st anthony's fire 10.1
14 major affective disorder 1 10.1
15 subacute delirium 10.1
16 postpartum depression 10.1
17 graves disease 1 10.0
18 eclampsia 10.0
19 schizoaffective disorder 10.0
20 capgras syndrome 10.0
21 thyroiditis 10.0
22 depression 10.0
23 schizophrenia 9.9
24 hydatidiform mole, recurrent, 1 9.9
25 meningioma, radiation-induced 9.9
26 meningioma, familial 9.9
27 glucocorticoid resistance, generalized 9.9
28 spinal meningioma 9.9
29 leukemia 9.9
30 disease of mental health 9.9
31 gestational trophoblastic neoplasm 9.9
32 secretory meningioma 9.9
33 lymphoplasmacyte-rich meningioma 9.9
34 neurotic disorder 9.9
35 severe combined immunodeficiency 9.9
36 premenstrual tension 9.9
37 placenta disease 9.9
38 reye syndrome 9.9 OTC ASS1
39 ornithine transcarbamylase deficiency, hyperammonemia due to 9.8 OTC ASS1
40 hashimoto thyroiditis 9.8
41 systemic lupus erythematosus 9.8
42 teratoma, ovarian 9.8
43 autism 9.8
44 myasthenia gravis 9.8
45 ocular motor apraxia 9.8
46 phenylketonuria 9.8
47 pre-eclampsia 9.8
48 mastitis 9.8
49 depersonalization disorder 9.8
50 asphyxia neonatorum 9.8

Graphical network of the top 20 diseases related to Postpartum Psychosis:



Diseases related to Postpartum Psychosis

Symptoms & Phenotypes for Postpartum Psychosis

Drugs & Therapeutics for Postpartum Psychosis

Drugs for Postpartum Psychosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 2 50-28-2 5757
2
Polyestradiol phosphate Approved Phase 2 28014-46-2
3 Estrogens Phase 2
4 Contraceptive Agents Phase 2
5 Hormones Phase 2
6 Estradiol 17 beta-cypionate Phase 2
7 Estradiol 3-benzoate Phase 2
8 Hormone Antagonists Phase 2
9 Antipsychotic Agents Phase 2
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Double Blind Study of Estradiol Plus Neuroleptic Versus Placebo Plus Neuroleptic in the Treatment of Psychotic Symptoms in Women With Schizophrenia Completed NCT00206570 Phase 2 Estradiol
2 The Role of Psychoeducation on Perceived Social Support of Postpartum Others With a Psychotic Illness Unknown status NCT01172106
3 An Evaluation and Factor Analysis for Maternal Mental Health - The Analytic Study of the Shin Kong Wu Ho-Su Memorial Hospital Unknown status NCT01423331
4 Potential Risk Factors for Postpartum Psychosis Completed NCT00872313
5 Paternal Psychosis Evaluation After First Baby Born Completed NCT01011088
6 A Prospective Study of Pregnant and Postpartum Women With and Without Mood Disorders Recruiting NCT03615794
7 Community Based Maternal Healthcare Services Recruiting NCT03678415
8 Adjunctive Psychotherapy for Perinatal Bipolar Disorder Terminated NCT02402738

Search NIH Clinical Center for Postpartum Psychosis

Genetic Tests for Postpartum Psychosis

Anatomical Context for Postpartum Psychosis

MalaCards organs/tissues related to Postpartum Psychosis:

41
Brain, Thyroid, Breast, Monocytes, Testes, Eye, Cortex

Publications for Postpartum Psychosis

Articles related to Postpartum Psychosis:

(show top 50) (show all 451)
# Title Authors PMID Year
1
[Recent progress in autoimmune encephalitis and its related disorders]. 38
31341132 2019
2
Nursing interventions for patients with postpartum psychosis hospitalized in a psychiatric mother-baby unit: A qualitative study. 38
31250503 2019
3
Brain plasticity in pregnancy and the postpartum period: links to maternal caregiving and mental health. 38
30008085 2019
4
Recommendations of the Polish Psychiatric Association regarding the treatment of affective disorders in women of childbearing age. Part II: Bipolar disorder. 38
31317957 2019
5
Cytokine alterations in first-onset postpartum psychosis-clues for underlying immune dysregulation. 38
30974307 2019
6
Treatment of postpartum psychosis in a mother-baby unit: do both mother and baby benefit? 38
30663319 2019
7
Rehospitalization of Postpartum Depression and Psychosis After Electroconvulsive Therapy: A Population-Based Study With a Matched Control Group. 38
30807499 2019
8
Diagnostics and modern trends in therapy of postpartum depression. 38
31213061 2019
9
Fetomaternal Outcome in Eclampsia in Relationship with Gravidity. 38
30755549 2019
10
Postpartum psychosis in a non-native language-speaking patient: A perspective on language barriers and cultural competency. 38
31360910 2019
11
Maternal bereavement shortly before or during pregnancy and risk of postpartum psychotic illness: a population-based study from Denmark and Sweden. 38
31118817 2019
12
Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk? 38
30348609 2018
13
ECT in the Postpartum Period: A Retrospective Case Series from a Tertiary Health Care Center in India. 38
30533953 2018
14
The impact of postpartum psychosis on partners. 38
30352559 2018
15
The psychometric properties of the 16-item version of the Prodromal Questionnaire (PQ-16) as a screening instrument for perinatal psychosis. 38
29560530 2018
16
Recognizing and Managing Postpartum Psychosis: A Clinical Guide for Obstetric Providers. 38
30092921 2018
17
Treatment of Peripartum Bipolar Disorder. 38
30092918 2018
18
Stratification of the risk of bipolar disorder recurrences in pregnancy and postpartum. 38
30113284 2018
19
Anti-NMDA receptor encephalitis presenting as postpartum psychosis-a clinical description and review. 38
29417305 2018
20
Mothers with acute and chronic postpartum psychoses and impact on the mother-infant interaction. 38
29496331 2018
21
Postpartum psychiatric disorders. 38
29695824 2018
22
Are infectious agents involved in the pathogenesis of postpartum psychosis? 38
29310062 2018
23
Qualitative exploration of the effect of a television soap opera storyline on women with experience of postpartum psychosis. 38
29971150 2018
24
Postpartum Psychosis in a Young VA Patient: Diagnosis, Implications, and Treatment Recommendations. 38
30766340 2018
25
Mania triggered by sleep loss and risk of postpartum psychosis in women with bipolar disorder. 38
28889048 2018
26
Large animals as potential models of human mental and behavioral disorders. 38
29432500 2017
27
Brain structure in women at risk of postpartum psychosis: an MRI study. 38
29249808 2017
28
Pharmacological Management of Bipolar Disorder in Pregnancy. 38
28786084 2017
29
Prescription of Sodium Valproate as a Mood Stabiliser in Pregnancy. 38
28953852 2017
30
Phenotypical characteristics of postpartum psychosis: A clinical cohort study. 38
28699248 2017
31
Immune system aberrations in postpartum psychosis: An immunophenotyping study from a tertiary care neuropsychiatric hospital in India. 38
28778450 2017
32
A qualitative investigation in the role of the baby in recovery from postpartum psychosis. 38
28138996 2017
33
Safe Use of Atypical Antipsychotics in a Patient With Postpartum Psychosis and a History of Seronegative Myasthenia Gravis. 38
28703945 2017
34
Homeopathic Treatment for Postpartum Depression: A Case Report. 38
28355103 2017
35
The global prevalence of postpartum psychosis: a systematic review. 38
28754094 2017
36
Understanding the pathophysiology of postpartum psychosis: Challenges and new approaches. 38
28713685 2017
37
Obstetrical, pregnancy and socio-economic predictors for new-onset severe postpartum psychiatric disorders in primiparous women. 38
28112056 2017
38
Protection against hormone-mediated mood symptoms. 38
27987053 2017
39
Estrogen pathway related genes and their association with risk of postpartum psychosis: A case control study. 38
28483099 2017
40
Catatonia among women with postpartum psychosis in a Mother-Baby inpatient psychiatry unit. 38
28274337 2017
41
Some unusual forms of early onset postpartum psychosis. 38
27744500 2017
42
Erratum to: Non-reproductive triggers of postpartum psychosis. 38
27917438 2017
43
Suicide and filicide in postpartum psychosis. 38
27778148 2017
44
Non-reproductive triggers of postpartum psychosis. 38
27722949 2017
45
Men's experiences of having a partner who requires Mother and Baby Unit admission for first episode postpartum psychosis. 38
27533096 2017
46
Recurrent episodes associated with childbearing: a matrix of associations. 38
27752784 2017
47
Relapses of bipolar/cycloid psychosis related to childbearing. 38
27738781 2017
48
Late onset postpartum psychoses. 38
27714460 2017
49
T Cell Deficits and Overexpression of Hepatocyte Growth Factor in Anti-inflammatory Circulating Monocytes of Middle-Aged Patients with Bipolar Disorder Characterized by a High Prevalence of the Metabolic Syndrome. 38
28373847 2017
50
Functional Recovery After Postpartum Psychosis: A Prospective Longitudinal Study. 38
27631144 2017

Variations for Postpartum Psychosis

Expression for Postpartum Psychosis

Search GEO for disease gene expression data for Postpartum Psychosis.

Pathways for Postpartum Psychosis

Pathways related to Postpartum Psychosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.58 OTC ASS1
2 11.11 OTC ASS1
3
Show member pathways
10.37 OTC ASS1
4
Show member pathways
10 OTC ASS1

GO Terms for Postpartum Psychosis

Biological processes related to Postpartum Psychosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of angiogenesis GO:0016525 9.4 MIR212 MIR146A
2 liver development GO:0001889 9.37 OTC ASS1
3 cellular amino acid biosynthetic process GO:0008652 9.32 OTC ASS1
4 response to zinc ion GO:0010043 9.26 OTC ASS1
5 urea cycle GO:0000050 9.16 OTC ASS1
6 midgut development GO:0007494 8.96 OTC ASS1
7 arginine biosynthetic process GO:0006526 8.62 OTC ASS1

Molecular functions related to Postpartum Psychosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 8.96 MIR212 MIR146A
2 amino acid binding GO:0016597 8.62 OTC ASS1

Sources for Postpartum Psychosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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