MCID: PST103
MIFTS: 32

Postpartum Psychosis

Categories: Rare diseases, Reproductive diseases

Aliases & Classifications for Postpartum Psychosis

MalaCards integrated aliases for Postpartum Psychosis:

Name: Postpartum Psychosis 58 71
Puerperal Psychosis 58

Characteristics:

Orphanet epidemiological data:

58
postpartum psychosis
Inheritance: Not applicable;

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

ICD10 via Orphanet 33 F53.1
UMLS via Orphanet 72 C0520678
Orphanet 58 ORPHA443173
UMLS 71 C0520678

Summaries for Postpartum Psychosis

MalaCards based summary : Postpartum Psychosis, also known as puerperal psychosis, is related to carbamoyl phosphate synthetase i deficiency, hyperammonemia due to and carbonic anhydrase va deficiency, hyperammonemia due to. An important gene associated with Postpartum Psychosis is ASS1 (Argininosuccinate Synthase 1), and among its related pathways/superpathways are Carbon metabolism and Amino Acid metabolism. The drugs Estradiol and Polyestradiol phosphate have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and breast.

Wikipedia : 74 Early in the history of medicine it was recognized that severe mental illness sometimes started abruptly... more...

Related Diseases for Postpartum Psychosis

Diseases related to Postpartum Psychosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 carbamoyl phosphate synthetase i deficiency, hyperammonemia due to 29.7 OTC ASS1
2 carbonic anhydrase va deficiency, hyperammonemia due to 29.7 OTC ASS1
3 argininosuccinic aciduria 29.6 OTC ASS1
4 urea cycle disorder 29.6 OTC ASS1
5 citrullinemia, classic 29.6 OTC ASS1
6 phenylketonuria 29.5 OTC ASS1
7 major affective disorder 8 10.5
8 major affective disorder 9 10.5
9 bipolar disorder 10.5
10 mood disorder 10.3
11 psychotic disorder 10.3
12 encephalitis 10.2
13 mental depression 10.1
14 st anthony's fire 10.1
15 major affective disorder 1 10.1
16 schizoaffective disorder 10.1
17 subacute delirium 10.1
18 postpartum depression 10.1
19 pyrimidine metabolic disorder 10.0 OTC ASS1
20 citrullinemia, type ii, adult-onset 10.0 OTC ASS1
21 hyperornithinemia-hyperammonemia-homocitrullinuria syndrome 10.0 OTC ASS1
22 acyl-coa dehydrogenase deficiency 10.0 OTC ASS1
23 graves disease 1 10.0
24 eclampsia 10.0
25 bipolar i disorder 10.0
26 capgras syndrome 10.0
27 thyroiditis 10.0
28 depression 10.0
29 ornithine transcarbamylase deficiency, hyperammonemia due to 10.0 OTC ASS1
30 reye syndrome 10.0 OTC ASS1
31 argininemia 10.0 OTC ASS1
32 schizophrenia 9.9
33 hydatidiform mole, recurrent, 1 9.9
34 meningioma, radiation-induced 9.9
35 meningioma, familial 9.9
36 glucocorticoid resistance, generalized 9.9
37 spinal meningioma 9.9
38 leukemia 9.9
39 disease of mental health 9.9
40 gestational trophoblastic neoplasm 9.9
41 secretory meningioma 9.9
42 lymphoplasmacyte-rich meningioma 9.9
43 neurotic disorder 9.9
44 severe combined immunodeficiency 9.9
45 premenstrual tension 9.9
46 placenta disease 9.9
47 orotic aciduria 9.9 OTC ASS1
48 lysinuric protein intolerance 9.9 OTC ASS1
49 propionic acidemia 9.9 OTC ASS1
50 amino acid metabolic disorder 9.9 OTC ASS1

Graphical network of the top 20 diseases related to Postpartum Psychosis:



Diseases related to Postpartum Psychosis

Symptoms & Phenotypes for Postpartum Psychosis

Drugs & Therapeutics for Postpartum Psychosis

Drugs for Postpartum Psychosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 2 50-28-2 5757
2
Polyestradiol phosphate Approved Phase 2 28014-46-2
3 Hormone Antagonists Phase 2
4 Estradiol 17 beta-cypionate Phase 2
5 Estradiol 3-benzoate Phase 2
6 Antipsychotic Agents Phase 2
7 Estrogens Phase 2
8 Hormones Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Double Blind Study of Estradiol Plus Neuroleptic Versus Placebo Plus Neuroleptic in the Treatment of Psychotic Symptoms in Women With Schizophrenia Completed NCT00206570 Phase 2 Estradiol
2 The Role of Psychoeducation on Perceived Social Support of Postpartum Others With a Psychotic Illness Unknown status NCT01172106
3 An Evaluation and Factor Analysis for Maternal Mental Health - The Analytic Study of the Shin Kong Wu Ho-Su Memorial Hospital Unknown status NCT01423331
4 Potential Risk Factors for Postpartum Psychosis Completed NCT00872313
5 Paternal Psychosis Evaluation After First Baby Born Completed NCT01011088
6 Community Based Maternal Healthcare Services Completed NCT03678415
7 A Prospective Study of Pregnant and Postpartum Women With and Without Mood Disorders Recruiting NCT03615794
8 Adjunctive Psychotherapy for Perinatal Bipolar Disorder Terminated NCT02402738

Search NIH Clinical Center for Postpartum Psychosis

Genetic Tests for Postpartum Psychosis

Anatomical Context for Postpartum Psychosis

MalaCards organs/tissues related to Postpartum Psychosis:

40
Brain, Thyroid, Breast, Monocytes, Eye, Cortex, Testes

Publications for Postpartum Psychosis

Articles related to Postpartum Psychosis:

(show top 50) (show all 469)
# Title Authors PMID Year
1
Supporting women who develop poor postnatal mental health: what support do fathers receive to support their partner and their own mental health? 61
32564772 2020
2
Postpartum psychosis in peripartum cardiomyopathy: a case report. 61
32160870 2020
3
Psychiatric disorders and changes in immune response in labor and postpartum. 61
32114440 2020
4
Neurocognitive correlates of working memory and emotional processing in postpartum psychosis: an fMRI study. 61
32174288 2020
5
Biological stress response in women at risk of postpartum psychosis: The role of life events and inflammation. 61
31923613 2020
6
Long-Term Outcomes of Postpartum Psychosis: A Systematic Review and Meta-Analysis. 61
32160423 2020
7
Recovery from postpartum psychosis: a systematic review and metasynthesis of women's and families' experiences. 61
32020314 2020
8
Adverse childhood experiences and postpartum depression in bipolar disorder. 61
31744744 2020
9
Postpartum psychosis in bipolar disorder: no evidence of association with personality traits, cognitive style or affective temperaments. 61
31830938 2019
10
Preeclampsia as a risk factor for postpartum depression and psychosis: a systematic review and meta-analysis. 61
31802249 2019
11
Rehospitalization of Postpartum Depression and Psychosis After Electroconvulsive Therapy: A Population-Based Study With a Matched Control Group. 61
31764450 2019
12
Psychological interventions for managing postpartum psychosis: a qualitative analysis of women's and family members' experiences and preferences. 61
31856785 2019
13
Postpartum psychosis in Sturge-Weber syndrome: A case report. 61
31896875 2019
14
Mental disorders/difficulties in the postpartum period. 61
31488750 2019
15
Nursing interventions for patients with postpartum psychosis hospitalized in a psychiatric mother-baby unit: A qualitative study. 61
31250503 2019
16
[Recent progress in autoimmune encephalitis and its related disorders]. 61
31341132 2019
17
Puerperal Psychosis: A brief review and unusual case report. 61
31452852 2019
18
Recommendations of the Polish Psychiatric Association regarding the treatment of affective disorders in women of childbearing age. Part II: Bipolar disorder. 61
31317957 2019
19
Brain plasticity in pregnancy and the postpartum period: links to maternal caregiving and mental health. 61
30008085 2019
20
Cytokine alterations in first-onset postpartum psychosis-clues for underlying immune dysregulation. 61
30974307 2019
21
Treatment of postpartum psychosis in a mother-baby unit: do both mother and baby benefit? 61
30663319 2019
22
Rehospitalization of Postpartum Depression and Psychosis After Electroconvulsive Therapy: A Population-Based Study With a Matched Control Group. 61
30807499 2019
23
Diagnostics and modern trends in therapy of postpartum depression. 61
31213061 2019
24
Fetomaternal Outcome in Eclampsia in Relationship with Gravidity. 61
30755549 2019
25
An Analysis of Cellular Communication Network Factor Proteins as Candidate Mediators of Postpartum Psychosis Risk. 61
31849729 2019
26
Postpartum psychosis in a non-native language-speaking patient: A perspective on language barriers and cultural competency. 61
31360910 2019
27
Maternal bereavement shortly before or during pregnancy and risk of postpartum psychotic illness: a population-based study from Denmark and Sweden. 61
31118817 2019
28
Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk? 61
30348609 2018
29
ECT in the Postpartum Period: A Retrospective Case Series from a Tertiary Health Care Center in India. 61
30533953 2018
30
The impact of postpartum psychosis on partners. 61
30352559 2018
31
The psychometric properties of the 16-item version of the Prodromal Questionnaire (PQ-16) as a screening instrument for perinatal psychosis. 61
29560530 2018
32
Recognizing and Managing Postpartum Psychosis: A Clinical Guide for Obstetric Providers. 61
30092921 2018
33
Stratification of the risk of bipolar disorder recurrences in pregnancy and postpartum. 61
30113284 2018
34
Treatment of Peripartum Bipolar Disorder. 61
30092918 2018
35
Anti-NMDA receptor encephalitis presenting as postpartum psychosis-a clinical description and review. 61
29417305 2018
36
Mothers with acute and chronic postpartum psychoses and impact on the mother-infant interaction. 61
29496331 2018
37
Postpartum psychiatric disorders. 61
29695824 2018
38
Are infectious agents involved in the pathogenesis of postpartum psychosis? 61
29310062 2018
39
Qualitative exploration of the effect of a television soap opera storyline on women with experience of postpartum psychosis. 61
29971150 2018
40
Postpartum Psychosis in a Young VA Patient: Diagnosis, Implications, and Treatment Recommendations. 61
30766340 2018
41
Mania triggered by sleep loss and risk of postpartum psychosis in women with bipolar disorder. 61
28889048 2018
42
A Mother's Love? Postpartum Disorders, the DSM-5 and Criminal Responsibility - A South African Medicolegal Perspective. 61
31984015 2018
43
Large animals as potential models of human mental and behavioral disorders. 61
29432500 2017
44
Brain structure in women at risk of postpartum psychosis: an MRI study. 61
29249808 2017
45
Pharmacological Management of Bipolar Disorder in Pregnancy. 61
28786084 2017
46
Prescription of Sodium Valproate as a Mood Stabiliser in Pregnancy. 61
28953852 2017
47
Phenotypical characteristics of postpartum psychosis: A clinical cohort study. 61
28699248 2017
48
Immune system aberrations in postpartum psychosis: An immunophenotyping study from a tertiary care neuropsychiatric hospital in India. 61
28778450 2017
49
A qualitative investigation in the role of the baby in recovery from postpartum psychosis. 61
28138996 2017
50
Safe Use of Atypical Antipsychotics in a Patient With Postpartum Psychosis and a History of Seronegative Myasthenia Gravis. 61
28703945 2017

Variations for Postpartum Psychosis

Expression for Postpartum Psychosis

Search GEO for disease gene expression data for Postpartum Psychosis.

Pathways for Postpartum Psychosis

Pathways related to Postpartum Psychosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.58 OTC ASS1
2 11.11 OTC ASS1
3
Show member pathways
10.37 OTC ASS1
4
Show member pathways
10 OTC ASS1

GO Terms for Postpartum Psychosis

Biological processes related to Postpartum Psychosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.46 MIR146A ASS1
2 negative regulation of angiogenesis GO:0016525 9.43 MIR212 MIR146A
3 miRNA mediated inhibition of translation GO:0035278 9.4 MIR212 MIR146A
4 liver development GO:0001889 9.37 OTC ASS1
5 cellular amino acid biosynthetic process GO:0008652 9.32 OTC ASS1
6 response to zinc ion GO:0010043 9.26 OTC ASS1
7 urea cycle GO:0000050 9.16 OTC ASS1
8 midgut development GO:0007494 8.96 OTC ASS1
9 arginine biosynthetic process GO:0006526 8.62 OTC ASS1

Molecular functions related to Postpartum Psychosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amino acid binding GO:0016597 8.62 OTC ASS1

Sources for Postpartum Psychosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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