Postsurgical Hypothyroidism disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Postsurgical Hypothyroidism

MalaCards integrated aliases for Postsurgical Hypothyroidism:

Name: Postsurgical Hypothyroidism ¹² ¹⁵

Postoperative Hypothyroidism ¹² ⁷³

Post-Surgical Hypothyroidism ¹²

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Endocrine, nutritional and metabolic diseases

Metabolic disorders

Postprocedural endocrine and metabolic disorders, not elsewhere classified

Postprocedural hypothyroidism

External Ids:

Disease Ontology ¹² DOID:1458

ICD10 ³³ E89.0

ICD9CM ³⁵ 244.0

SNOMED-CT ⁶⁸ 154662008 190275002 27059002

UMLS ⁷³ C0154157

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Summaries for Postsurgical Hypothyroidism

MalaCards based summary : Postsurgical Hypothyroidism, also known as postoperative hypothyroidism, is related to fungal esophagitis and bladder calculus. An important gene associated with Postsurgical Hypothyroidism is AURKA (Aurora Kinase A). The drugs Hormone Antagonists and Hormones have been mentioned in the context of this disorder. Affiliated tissues include thyroid, and related phenotype is hematopoietic system.

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Related Diseases for Postsurgical Hypothyroidism

Diseases related to Postsurgical Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)

#	Related Disease	Score	Top Affiliating Genes
1	fungal esophagitis	10.2	ATP12A ATP4A
2	bladder calculus	10.2	ATP12A ATP4A
3	gastrointestinal neuroendocrine benign tumor	10.2	ATP12A ATP4A
4	neonatal candidiasis	10.1	ATP12A ATP4A
5	photoallergic dermatitis	10.1	ATP12A ATP4A
6	squamous papillomatosis	10.1	ATP12A ATP4A
7	acute laryngitis	10.1	ATP12A ATP4A
8	gastroduodenal crohn's disease	10.1	ATP12A ATP4A
9	gastric neuroendocrine neoplasm	10.1	ATP12A ATP4A
10	toxic megacolon	10.1	ATP12A ATP4A
11	aspiration pneumonitis	10.1	ATP12A ATP4A
12	gastric antral vascular ectasia	10.1	ATP12A ATP4A
13	esophageal candidiasis	10.1	ATP12A ATP4A
14	duodenitis	10.1	ATP12A ATP4A
15	rumination disorder	10.1	ATP12A ATP4A
16	bile reflux	10.1	ATP12A ATP4A
17	granulomatous gastritis	10.1	ATP12A ATP4A
18	active peptic ulcer disease	10.1	ATP12A ATP4A
19	laryngeal disease	10.1	ATP12A ATP4A
20	ischemic neuropathy	10.1	ATP12A ATP4A
21	capillary disease	10.1	ATP12A ATP4A
22	peptic esophagitis	10.1	ATP12A ATP4A
23	duodenal disease	10.1	ATP12A ATP4A
24	dyskinesia of esophagus	10.1	ATP12A ATP4A
25	hernia, hiatus	10.1	ATP12A ATP4A
26	congenital disorder of deglycosylation	10.1	ATP12A ATP4A
27	anismus	10.1	ATP12A ATP4A
28	esophageal atresia/tracheoesophageal fistula	10.1	ATP12A ATP4A
29	laryngitis	10.1	ATP12A ATP4A
30	laryngeal tuberculosis	10.1	ATP12A ATP4A
31	lymphocytic colitis	10.1	ATP12A ATP4A
32	clostridium difficile colitis	10.1	ATP12A ATP4A
33	lower urinary tract calculus	10.1	ATP12A ATP4A
34	aspiration pneumonia	10.0	ATP12A ATP4A
35	diarrhea 1, secretory chloride, congenital	10.0	ATP12A ATP4A
36	chronic laryngitis	10.0	ATP12A ATP4A
37	substernal goiter	10.0	PTH TG
38	chronic intestinal vascular insufficiency	10.0	ATP12A ATP4A
39	water-clear cell adenoma	10.0	PTH TG
40	thyroid crisis	10.0	PTH TG
41	eosinophilic gastritis	10.0	ATP12A ATP4A
42	polyposis, skin pigmentation, alopecia, and fingernail changes	10.0	ATP12A ATP4A
43	esophageal varix	10.0	ATP12A ATP4A
44	esophagus adenocarcinoma	10.0	ATP12A ATP4A
45	myopathy, x-linked, with excessive autophagy	10.0	ATP12A ATP4A
46	clear cell adenoma	10.0	PTH TG
47	gastric lymphoma	10.0	ATP12A ATP4A
48	pancreatic steatorrhea	10.0	ATP12A ATP4A
49	pneumatosis cystoides intestinalis	10.0	ATP12A ATP4A
50	superior mesenteric artery syndrome	10.0	ATP12A ATP4A

Comorbidity relations with Postsurgical Hypothyroidism via Phenotypic Disease Network (PDN): (show all 12)

Acute Cystitis	Deficiency Anemia
Familial Atrial Fibrillation	Heart Disease
Hypertension, Essential	Hypoparathyroidism
Hypothyroidism	Intermediate Coronary Syndrome
Ischemic Heart Disease	Mitral Valve Disease
Osteoporosis	Thyroid Cancer

Graphical network of the top 20 diseases related to Postsurgical Hypothyroidism:

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Symptoms & Phenotypes for Postsurgical Hypothyroidism

MGI Mouse Phenotypes related to Postsurgical Hypothyroidism:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.1	ATP4A AURKA CSF3 HP PTH TG

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Drugs & Therapeutics for Postsurgical Hypothyroidism

Drugs for Postsurgical Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Hormone Antagonists
2	Hormones
3	Hormones, Hormone Substitutes, and Hormone Antagonists

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Levothyroxine Replacement With Liquid Gel Capsules vs Tablets Post-thyroidectomy	Recruiting	NCT02946918	Phase 4	Levothyroxine
2	Levothyroxine Treatment for Subclinical Hypothyroidism After Head and Neck Surgery	Unknown status	NCT02548715	Phase 2, Phase 3	Levothyroxine;Placebo
3	EIS in Thyroid and Parathyroid Surgery	Recruiting	NCT02901873	Phase 1
4	Is Levothyroxine Alone Adequate Thyroid Hormone Replacement?	Recruiting	NCT02567877		levothyroxine in thyroidectomy patients

Search NIH Clinical Center for Postsurgical Hypothyroidism

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Genetic Tests for Postsurgical Hypothyroidism

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Anatomical Context for Postsurgical Hypothyroidism

MalaCards organs/tissues related to Postsurgical Hypothyroidism:

⁴¹

Thyroid

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Publications for Postsurgical Hypothyroidism

Articles related to Postsurgical Hypothyroidism:

#	Title	Authors	Year
1	Early Cardiac Tamponade in a Patient with Postsurgical Hypothyroidism. ( 26294982 )	Sinha A....Curry B.H.	2015
2	Thyroid function after unilateral total lobectomy: risk factors for postoperative hypothyroidism. ( 18936354 )	De Carlucci D....Cernea C.R.	2008
3	NIS mRNA expression level in resected thyroid tissue as a marker of postoperative hypothyroidism after subtotal thyroidectomy in patients with Graves' disease. ( 18187871 )	Goto A....Onji M.	2008
4	[Postoperative hypothyroidism in patients with multi-nodular goiter]. ( 12953431 )	Saidova F.K.h.	2003

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Genes for Postsurgical Hypothyroidism

Genes related to Postsurgical Hypothyroidism (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	AURKA	Aurora Kinase A	Protein Coding	14.71	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	TG	Thyroglobulin	Protein Coding	14.6	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	HP	Haptoglobin	Protein Coding	14.11	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	ATP12A	ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit	Protein Coding	13.63	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	13.63	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	PTH	Parathyroid Hormone	Protein Coding	13.03	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	CSF3	Colony Stimulating Factor 3	Protein Coding	3.48	DISEASES inferred ¹⁵

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Variations for Postsurgical Hypothyroidism

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Expression for Postsurgical Hypothyroidism

Search GEO for disease gene expression data for Postsurgical Hypothyroidism.

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Pathways for Postsurgical Hypothyroidism

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GO Terms for Postsurgical Hypothyroidism

Cellular components related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.02	ATP4A CSF3 HP PTH TG

Biological processes related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of signaling receptor activity	GO:0010469	9.58	CSF3 PTH TG
2	potassium ion import	GO:0010107	9.37	ATP12A ATP4A
3	ATP hydrolysis coupled proton transport	GO:0015991	9.32	ATP12A ATP4A
4	cellular sodium ion homeostasis	GO:0006883	9.26	ATP12A ATP4A
5	cellular potassium ion homeostasis	GO:0030007	9.16	ATP12A ATP4A
6	sodium ion export across plasma membrane	GO:0036376	8.96	ATP12A ATP4A
7	establishment or maintenance of transmembrane electrochemical gradient	GO:0010248	8.62	ATP12A ATP4A

Molecular functions related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	9.16	PTH TG
2	sodium:potassium-exchanging ATPase activity	GO:0005391	8.96	ATP12A ATP4A
3	potassium:proton exchanging ATPase activity	GO:0008900	8.62	ATP12A ATP4A

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Sources for Postsurgical Hypothyroidism

¹ BioSystems

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⁷⁶ Wikipedia