MCID: PST014
MIFTS: 26

Postsurgical Hypothyroidism

Categories: Endocrine diseases

Aliases & Classifications for Postsurgical Hypothyroidism

MalaCards integrated aliases for Postsurgical Hypothyroidism:

Name: Postsurgical Hypothyroidism 12 15
Postoperative Hypothyroidism 12 73
Post-Surgical Hypothyroidism 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1458
ICD10 33 E89.0
ICD9CM 35 244.0
UMLS 73 C0154157

Summaries for Postsurgical Hypothyroidism

MalaCards based summary : Postsurgical Hypothyroidism, also known as postoperative hypothyroidism, is related to fungal esophagitis and bladder calculus. An important gene associated with Postsurgical Hypothyroidism is AURKA (Aurora Kinase A). The drugs Hormone Antagonists and Hormones have been mentioned in the context of this disorder. Affiliated tissues include thyroid, and related phenotype is hematopoietic system.

Related Diseases for Postsurgical Hypothyroidism

Diseases related to Postsurgical Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 fungal esophagitis 10.2 ATP12A ATP4A
2 bladder calculus 10.2 ATP12A ATP4A
3 gastrointestinal neuroendocrine benign tumor 10.2 ATP12A ATP4A
4 neonatal candidiasis 10.1 ATP12A ATP4A
5 photoallergic dermatitis 10.1 ATP12A ATP4A
6 squamous papillomatosis 10.1 ATP12A ATP4A
7 acute laryngitis 10.1 ATP12A ATP4A
8 gastroduodenal crohn's disease 10.1 ATP12A ATP4A
9 gastric neuroendocrine neoplasm 10.1 ATP12A ATP4A
10 toxic megacolon 10.1 ATP12A ATP4A
11 aspiration pneumonitis 10.1 ATP12A ATP4A
12 gastric antral vascular ectasia 10.1 ATP12A ATP4A
13 esophageal candidiasis 10.1 ATP12A ATP4A
14 duodenitis 10.1 ATP12A ATP4A
15 rumination disorder 10.1 ATP12A ATP4A
16 bile reflux 10.1 ATP12A ATP4A
17 granulomatous gastritis 10.1 ATP12A ATP4A
18 active peptic ulcer disease 10.1 ATP12A ATP4A
19 laryngeal disease 10.1 ATP12A ATP4A
20 ischemic neuropathy 10.1 ATP12A ATP4A
21 capillary disease 10.1 ATP12A ATP4A
22 peptic esophagitis 10.1 ATP12A ATP4A
23 duodenal disease 10.1 ATP12A ATP4A
24 dyskinesia of esophagus 10.1 ATP12A ATP4A
25 hernia, hiatus 10.1 ATP12A ATP4A
26 congenital disorder of deglycosylation 10.1 ATP12A ATP4A
27 anismus 10.1 ATP12A ATP4A
28 esophageal atresia/tracheoesophageal fistula 10.1 ATP12A ATP4A
29 laryngitis 10.1 ATP12A ATP4A
30 laryngeal tuberculosis 10.1 ATP12A ATP4A
31 lymphocytic colitis 10.1 ATP12A ATP4A
32 clostridium difficile colitis 10.1 ATP12A ATP4A
33 lower urinary tract calculus 10.1 ATP12A ATP4A
34 aspiration pneumonia 10.0 ATP12A ATP4A
35 diarrhea 1, secretory chloride, congenital 10.0 ATP12A ATP4A
36 chronic laryngitis 10.0 ATP12A ATP4A
37 substernal goiter 10.0 PTH TG
38 chronic intestinal vascular insufficiency 10.0 ATP12A ATP4A
39 water-clear cell adenoma 10.0 PTH TG
40 thyroid crisis 10.0 PTH TG
41 eosinophilic gastritis 10.0 ATP12A ATP4A
42 polyposis, skin pigmentation, alopecia, and fingernail changes 10.0 ATP12A ATP4A
43 esophageal varix 10.0 ATP12A ATP4A
44 esophagus adenocarcinoma 10.0 ATP12A ATP4A
45 myopathy, x-linked, with excessive autophagy 10.0 ATP12A ATP4A
46 clear cell adenoma 10.0 PTH TG
47 gastric lymphoma 10.0 ATP12A ATP4A
48 pancreatic steatorrhea 10.0 ATP12A ATP4A
49 pneumatosis cystoides intestinalis 10.0 ATP12A ATP4A
50 superior mesenteric artery syndrome 10.0 ATP12A ATP4A

Comorbidity relations with Postsurgical Hypothyroidism via Phenotypic Disease Network (PDN): (show all 12)


Acute Cystitis Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypoparathyroidism
Hypothyroidism Intermediate Coronary Syndrome
Ischemic Heart Disease Mitral Valve Disease
Osteoporosis Thyroid Cancer

Graphical network of the top 20 diseases related to Postsurgical Hypothyroidism:



Diseases related to Postsurgical Hypothyroidism

Symptoms & Phenotypes for Postsurgical Hypothyroidism

MGI Mouse Phenotypes related to Postsurgical Hypothyroidism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.1 ATP4A AURKA CSF3 HP PTH TG

Drugs & Therapeutics for Postsurgical Hypothyroidism

Drugs for Postsurgical Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormone Antagonists
2 Hormones
3 Hormones, Hormone Substitutes, and Hormone Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Levothyroxine Replacement With Liquid Gel Capsules vs Tablets Post-thyroidectomy Recruiting NCT02946918 Phase 4 Levothyroxine
2 Levothyroxine Treatment for Subclinical Hypothyroidism After Head and Neck Surgery Unknown status NCT02548715 Phase 2, Phase 3 Levothyroxine;Placebo
3 EIS in Thyroid and Parathyroid Surgery Recruiting NCT02901873 Phase 1
4 Is Levothyroxine Alone Adequate Thyroid Hormone Replacement? Recruiting NCT02567877 levothyroxine in thyroidectomy patients

Search NIH Clinical Center for Postsurgical Hypothyroidism

Genetic Tests for Postsurgical Hypothyroidism

Anatomical Context for Postsurgical Hypothyroidism

MalaCards organs/tissues related to Postsurgical Hypothyroidism:

41
Thyroid

Publications for Postsurgical Hypothyroidism

Articles related to Postsurgical Hypothyroidism:

# Title Authors Year
1
Early Cardiac Tamponade in a Patient with Postsurgical Hypothyroidism. ( 26294982 )
2015
2
Thyroid function after unilateral total lobectomy: risk factors for postoperative hypothyroidism. ( 18936354 )
2008
3
NIS mRNA expression level in resected thyroid tissue as a marker of postoperative hypothyroidism after subtotal thyroidectomy in patients with Graves' disease. ( 18187871 )
2008
4
[Postoperative hypothyroidism in patients with multi-nodular goiter]. ( 12953431 )
2003

Variations for Postsurgical Hypothyroidism

Expression for Postsurgical Hypothyroidism

Search GEO for disease gene expression data for Postsurgical Hypothyroidism.

Pathways for Postsurgical Hypothyroidism

GO Terms for Postsurgical Hypothyroidism

Cellular components related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 ATP4A CSF3 HP PTH TG

Biological processes related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.58 CSF3 PTH TG
2 potassium ion import GO:0010107 9.37 ATP12A ATP4A
3 ATP hydrolysis coupled proton transport GO:0015991 9.32 ATP12A ATP4A
4 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
5 cellular potassium ion homeostasis GO:0030007 9.16 ATP12A ATP4A
6 sodium ion export across plasma membrane GO:0036376 8.96 ATP12A ATP4A
7 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP12A ATP4A

Molecular functions related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.16 PTH TG
2 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Postsurgical Hypothyroidism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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