MCID: PST014
MIFTS: 32

Postsurgical Hypothyroidism

Categories: Endocrine diseases

Aliases & Classifications for Postsurgical Hypothyroidism

MalaCards integrated aliases for Postsurgical Hypothyroidism:

Name: Postsurgical Hypothyroidism 12 15
Postoperative Hypothyroidism 12 71
Post-Surgical Hypothyroidism 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1458
ICD9CM 34 244.0
SNOMED-CT 67 27059002
ICD10 32 E89.0
UMLS 71 C0154157

Summaries for Postsurgical Hypothyroidism

MalaCards based summary : Postsurgical Hypothyroidism, also known as postoperative hypothyroidism, is related to exophthalmos and myxedema. An important gene associated with Postsurgical Hypothyroidism is TG (Thyroglobulin), and among its related pathways/superpathways is Thyroxine (Thyroid Hormone) Production. The drugs Parathyroid hormone and Hormones have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and kidney, and related phenotypes are cardiovascular system and limbs/digits/tail

Related Diseases for Postsurgical Hypothyroidism

Diseases related to Postsurgical Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 exophthalmos 29.3 TPO TG
2 myxedema 29.1 TPO TG FHL2
3 hypoparathyroidism 29.1 TPO RET PTH
4 nodular goiter 28.9 TPO TG RET
5 thyroid carcinoma 28.9 TPO TG RET
6 pendred syndrome 28.9 TPO TG
7 graves disease 1 28.8 TRH TPO TG PTH
8 multinodular goiter 28.8 TPO TG RET PTH
9 hyperthyroidism 28.8 TRH TPO TG PTH
10 adenoma 28.7 TRH TG RET PTH
11 hypothyroidism 28.7 TRH TPO TG RET
12 thyroiditis 28.6 TRH TPO TG RET
13 goiter 28.5 TRH TPO TG RET
14 thyroid gland disease 27.5 TRH TPO TG RET PTH FHL2
15 substernal goiter 10.3 TG PTH
16 clear cell adenoma 10.3 TG PTH
17 hypothyroidism, congenital, nongoitrous, 1 10.3 TG PTH
18 multicentric papillary thyroid carcinoma 10.2 TG RET
19 benign struma ovarii 10.2 TG RET
20 struma ovarii 10.2 TG RET
21 atypical follicular adenoma 10.2 TG RET
22 malignant struma ovarii 10.2 TG RET
23 ovarian germ cell teratoma 10.1 TG RET
24 familial hypocalciuric hypercalcemia 10.1 RET PTH
25 euthyroid sick syndrome 10.0 TRH TG
26 thyroid gland medullary carcinoma 10.0 TG RET
27 thyroid hormone resistance, generalized, autosomal dominant 10.0 TRH TG
28 graves' disease 10.0
29 multiple endocrine neoplasia, type iia 10.0 RET PTH
30 pseudohypoparathyroidism, type ia 10.0 TRH PTH
31 pseudohypoparathyroidism 10.0 TRH PTH
32 parathyroid carcinoma 10.0 RET PTH
33 mechanical strabismus 10.0 TPO TG
34 tall cell variant papillary carcinoma 9.9 TG RET PTH
35 familial thyroid dyshormonogenesis 9.9 TPO TG
36 iodine hypothyroidism 9.9 TPO TG
37 papillary thyroid microcarcinoma 9.9
38 acute thyroiditis 9.9 TPO TG
39 thyroid crisis 9.9 TPO TG
40 parathyroid gland disease 9.9 TG RET PTH
41 toxic diffuse goiter 9.9 TPO TG
42 goiter, multinodular 1, with or without sertoli-leydig cell tumors 9.9 TPO TG
43 thyroid lymphoma 9.9 TPO TG
44 subacute lymphocytic thyroiditis 9.9 TPO TG
45 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9 TPO TG
46 thyroid carcinoma, familial medullary 9.9 TG RET
47 diabetes mellitus, insulin-dependent, 20 9.9 TPO TG
48 subacute thyroiditis 9.9 TPO TG
49 premature menopause 9.9 TPO TG
50 adrenal cortical hypofunction 9.9 TPO TG

Comorbidity relations with Postsurgical Hypothyroidism via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypoparathyroidism
Hypothyroidism Intermediate Coronary Syndrome
Mitral Valve Disease Osteoporosis

Graphical network of the top 20 diseases related to Postsurgical Hypothyroidism:



Diseases related to Postsurgical Hypothyroidism

Symptoms & Phenotypes for Postsurgical Hypothyroidism

MGI Mouse Phenotypes related to Postsurgical Hypothyroidism:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.63 FHL2 GRHL3 HNRNPF PTH RET TRH
2 limbs/digits/tail MP:0005371 9.35 GRHL3 PTH RET TG TPO
3 skeleton MP:0005390 9.1 FHL2 GRHL3 PTH TG TPO TRH

Drugs & Therapeutics for Postsurgical Hypothyroidism

Drugs for Postsurgical Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Parathyroid hormone Approved, Investigational 9002-64-6
2 Hormones

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ThyrOp: Individual Subclinical Hypothyroidism After Hemithyroidectomy for Benign Nontoxic Goiter - Focus on Weight Gain and Mitochondrial Dysfunction Unknown status NCT01358136
2 Phase 1 Study of Electrical Impedance Spectroscopy in Thyroid and Parathyroid Surgery Completed NCT02901873
3 Is Levothyroxine Alone Adequate Thyroid Hormone Replacement for All Patients? Recruiting NCT02567877 levothyroxine in thyroidectomy patients

Search NIH Clinical Center for Postsurgical Hypothyroidism

Genetic Tests for Postsurgical Hypothyroidism

Anatomical Context for Postsurgical Hypothyroidism

MalaCards organs/tissues related to Postsurgical Hypothyroidism:

40
Thyroid, Lymph Node, Kidney, Testes, Pituitary

Publications for Postsurgical Hypothyroidism

Articles related to Postsurgical Hypothyroidism:

(show top 50) (show all 142)
# Title Authors PMID Year
1
Oncological impact of hypothyroidism and levothyroxine supplementation following hemithyroidectomy in patients with papillary thyroid carcinoma. 61
31930773 2020
2
A BULL IN A PILL SHOP: ALPHA-GAL ALLERGY COMPLICATING TREATMENT OPTIONS FOR POSTPROCEDURAL HYPOTHYROIDISM. 61
32524021 2020
3
Different Formulations of Levothyroxine for Treating Hypothyroidism: A Real-Life Study. 61
32184819 2020
4
Usefulness of 1-year of thyroid stimulating hormone suppression on additional levothyroxine in patients who underwent hemithyroidectomy with papillary thyroid microcarcinoma. 61
32042670 2019
5
The Role of Serum Procalcitonin in Predicting Bacterial Sepsis in Patients With Hypothyroidism. 61
31361312 2019
6
Treatment of patients with Graves' disease and the appropriate extent of thyroidectomy. 61
31530446 2019
7
Presentation, Morbidity and Treatment Outcome of Acromegaly Patients at a Single Centre. 61
31741902 2019
8
Management of Subclinical and Overt Hypothyroidism Following Hemithyroidectomy in Children and Adolescents: A Pilot Study. 61
31612123 2019
9
Incidences of Hypothyroidism Associated With Surgical Procedures for Thyroid Disorders: A Nationwide Population-Based Study. 61
31920634 2019
10
Adequate restitution in primary hypothyroidism depending on levothyroxine formulations 61
30376277 2018
11
Relationship between perioperative thyroid function and acute kidney injury after thyroidectomy. 61
30201973 2018
12
Prevalence of hypothyroidism among patients with isthmus-preserved thyroid lobectomy. 61
29968481 2018
13
Hypothyroidism and Wound Healing After Salvage Laryngectomy. 61
29264671 2018
14
Pancytopenia: a rare complication of Graves' disease. 61
29525760 2018
15
Severe Hyperthyroidism Complicated by Agranulocytosis Treated with Therapeutic Plasma Exchange: Case Report and Review of the Literature. 61
29552362 2018
16
[Hypothyreosis after Hemithyroidectomy - surprisingly frequent complication in aftercare]. 61
28597456 2018
17
Review of Heterotopic Thyroid Autotransplantation. 61
28535579 2017
18
Effect of Thyroid Remnant Volume on the Risk of Hypothyroidism After Hemithyroidectomy: A Prospective Study. 61
28058547 2017
19
Comparison of endoscopic and conventional open thyroidectomy for Graves' disease: A meta-analysis. 61
28235670 2017
20
Clinical Features of Early and Late Postoperative Hypothyroidism After Lobectomy. 61
28324106 2017
21
Thyroid Surgery in a Resource-Limited Setting. 61
28025932 2017
22
Concurrent Hypoparathyroidism Is Associated With Impaired Physical Function and Quality of Life in Hypothyroidism. 61
26865527 2016
23
The Effect of Levothyroxine Discontinuation Timing on Postoperative Hypothyroidism after Hemithyroidectomy for Papillary Thyroid Microcarcinoma. 61
27293432 2016
24
[Cytoflavin rationale for the use in treatment of patients with postsurgical hypothyroidism]. 61
27459489 2016
25
Experimental autotransplantation and cryopreservation of the thyroid gland. 61
24634027 2015
26
Early severe fetal Graves disease in a mother after thyroid ablation and thyroidectomy. 61
25710616 2015
27
Factors associated with postoperative hypothyroidism after lobectomy in papillary thyroid microcarcinoma patients. 61
25111668 2015
28
Early Cardiac Tamponade in a Patient with Postsurgical Hypothyroidism. 61
26294982 2015
29
Prospective analysis of risk for hypothyroidism after hemithyroidectomy. 61
25918526 2015
30
Prediction of thyroid hormone supplementation after thyroid lobectomy. 61
25088372 2015
31
[Postoperative hypothyroidism]. 61
25962288 2015
32
Changes in body weight after treatment of primary hypothyroidism with levothyroxine. 61
24936556 2014
33
Highlights in thyroidology: a historical vignette. 61
24652010 2014
34
Clinical effectiveness of thyroidectomy on the management of locally advanced laryngeal cancer. 61
24176487 2014
35
[Risk factors for renal dysfunction in patients with hypothyroidism]. 61
25796821 2014
36
Are levothyroxine requirements lower in thyroidectomized diabetic patients on metformin treatment? 61
23758637 2013
37
Papillary thyroid carcinoma with thyroiditis: lymph node metastasis, complications. 61
23833756 2013
38
Thyroid hormone replacement therapy, surveillance ultrasonography, and fine-needle aspiration after hemithyroidectomy. 61
23951697 2013
39
Levothyroxine replacement dosage determination after thyroidectomy. 61
23369308 2013
40
What is the best definitive treatment for Graves' disease? A systematic review of the existing literature. 61
22956065 2013
41
Selective or radical surgical strategy in functional autonomy of the thyroid in endemic areas. 61
24151744 2013
42
Hemithyroidectomy: a meta-analysis of postoperative need for hormone replacement and complications. 61
23486083 2013
43
Risk of hypothyroidism following hemithyroidectomy: systematic review and meta-analysis of prognostic studies. 61
22511795 2012
44
Thyroid function after subtotal thyroidectomy in patients with Graves' hyperthyroidism. 61
22448136 2012
45
Weight changes in euthyroid patients undergoing thyroidectomy. 61
22066482 2011
46
Detection and management of hypothyroidism following thyroid lobectomy: evaluation of a clinical algorithm. 61
21547704 2011
47
Subclinical hypothyroidism following hemithyroidectomy: a simple risk-scoring system using age and preoperative thyrotropin level. 61
21212713 2011
48
Successful treatment of postsurgical hypoparathyroidism by intramuscular injection of vitamin D3 in a patient associated with malabsorption syndrome due to multiple abdominal surgeries. 61
19657589 2010
49
Hypothyroidism following hemithyroidectomy: a retrospective review. 61
19779329 2009
50
Thyroid hormone replacement after thyroid lobectomy. 61
19789012 2009

Variations for Postsurgical Hypothyroidism

Expression for Postsurgical Hypothyroidism

Search GEO for disease gene expression data for Postsurgical Hypothyroidism.

Pathways for Postsurgical Hypothyroidism

Pathways related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.58 TRH TPO TG

GO Terms for Postsurgical Hypothyroidism

Biological processes related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 thyroid hormone generation GO:0006590 8.96 TPO TG
2 hormone biosynthetic process GO:0042446 8.62 TPO TG

Molecular functions related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 TRH TG PTH

Sources for Postsurgical Hypothyroidism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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