MCID: PST014
MIFTS: 30

Postsurgical Hypothyroidism

Categories: Endocrine diseases

Aliases & Classifications for Postsurgical Hypothyroidism

MalaCards integrated aliases for Postsurgical Hypothyroidism:

Name: Postsurgical Hypothyroidism 12 15
Postoperative Hypothyroidism 12 73
Post-Surgical Hypothyroidism 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1458
ICD10 33 E89.0
ICD9CM 35 244.0
SNOMED-CT 68 27059002
UMLS 73 C0154157

Summaries for Postsurgical Hypothyroidism

MalaCards based summary : Postsurgical Hypothyroidism, also known as postoperative hypothyroidism, is related to papillary thyroid microcarcinoma and hypothyroidism. An important gene associated with Postsurgical Hypothyroidism is TG (Thyroglobulin), and among its related pathways/superpathways is Thyroxine (Thyroid Hormone) Production. The drugs Hormones, Hormone Substitutes, and Hormone Antagonists and Hormones have been mentioned in the context of this disorder. Affiliated tissues include thyroid, skin and t cells, and related phenotype is hematopoietic system.

Related Diseases for Postsurgical Hypothyroidism

Diseases related to Postsurgical Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 papillary thyroid microcarcinoma 30.0 TG TSHR
2 hypothyroidism 30.0 TG TRH TSHR
3 exophthalmos 29.7 TG TSHR
4 thyroiditis 29.7 TG TRH TSHR
5 benign struma ovarii 10.2 TG TSHR
6 struma ovarii 10.2 TG TSHR
7 neonatal hypothyroidism 10.2 TG TSHR
8 athyreosis 10.2 TG TSHR
9 thyroid hormone resistance, generalized, autosomal dominant 10.2 TG TRH
10 endemic goiter 10.2 TG TSHR
11 hypothyroidism, congenital, nongoitrous, 2 10.2 TG TSHR
12 nontoxic goiter 10.2 TG TSHR
13 myxedema 10.2 TG TSHR
14 subacute thyroiditis 10.2 TG TSHR
15 hyperthyroxinemia 10.2 TRH TSHR
16 thyroid crisis 10.2 MB TG
17 hypothyroidism, congenital, nongoitrous, 4 10.2 TG TRH
18 nodular goiter 10.1 TG TSHR
19 chronic orbital inflammation 10.1 CSF3 TSHR
20 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1 TG TSHR
21 graves disease 1 10.1 TG TRH TSHR
22 toxic diffuse goiter 10.1 TG TRH TSHR
23 goiter 10.1 TG TRH TSHR
24 thyroid gland disease 10.1 TG TRH TSHR
25 hyperthyroidism 10.1 TG TRH TSHR
26 autoimmune disease of endocrine system 10.1 TG TSHR
27 multinodular goiter 10.1 TG TSHR
28 fungal esophagitis 10.1 ATP12A ATP4A
29 diclofenac allergy 10.1 ATP12A ATP4A
30 gastroduodenal crohn's disease 10.1 ATP12A ATP4A
31 neonatal candidiasis 10.1 ATP12A ATP4A
32 photoallergic dermatitis 10.1 ATP12A ATP4A
33 squamous papillomatosis 10.1 ATP12A ATP4A
34 toxic megacolon 10.1 ATP12A ATP4A
35 aspiration pneumonitis 10.1 ATP12A ATP4A
36 gastrointestinal neuroendocrine benign tumor 10.1 ATP12A ATP4A
37 gastric antral vascular ectasia 10.0 ATP12A ATP4A
38 granulomatous gastritis 10.0 ATP12A ATP4A
39 esophageal candidiasis 10.0 ATP12A ATP4A
40 gastric neuroendocrine neoplasm 10.0 ATP12A ATP4A
41 acute laryngitis 10.0 ATP12A ATP4A
42 laryngitis 10.0 ATP12A ATP4A
43 duodenitis 10.0 ATP12A ATP4A
44 rumination disorder 10.0 ATP12A ATP4A
45 active peptic ulcer disease 10.0 ATP12A ATP4A
46 congenital disorder of deglycosylation 10.0 ATP12A ATP4A
47 bladder calculus 10.0 ATP12A ATP4A
48 ischemic neuropathy 10.0 ATP12A ATP4A
49 bile reflux 10.0 ATP12A ATP4A
50 capillary disease 10.0 ATP12A ATP4A

Comorbidity relations with Postsurgical Hypothyroidism via Phenotypic Disease Network (PDN): (show all 12)


Acute Cystitis Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypoparathyroidism
Hypothyroidism Intermediate Coronary Syndrome
Ischemic Heart Disease Mitral Valve Disease
Osteoporosis Thyroid Cancer

Graphical network of the top 20 diseases related to Postsurgical Hypothyroidism:



Diseases related to Postsurgical Hypothyroidism

Symptoms & Phenotypes for Postsurgical Hypothyroidism

MGI Mouse Phenotypes related to Postsurgical Hypothyroidism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.17 ATP4A AURKA CSF3 HP MB TG

Drugs & Therapeutics for Postsurgical Hypothyroidism

Drugs for Postsurgical Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones, Hormone Substitutes, and Hormone Antagonists
2 Hormones
3 Hormone Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Levothyroxine Replacement With Liquid Gel Capsules vs Tablets Post-thyroidectomy Recruiting NCT02946918 Phase 4 Levothyroxine
2 Levothyroxine Treatment for Subclinical Hypothyroidism After Head and Neck Surgery Unknown status NCT02548715 Phase 2, Phase 3 Levothyroxine;Placebo
3 EIS in Thyroid and Parathyroid Surgery Completed NCT02901873 Not Applicable
4 Is Levothyroxine Alone Adequate Thyroid Hormone Replacement? Recruiting NCT02567877 levothyroxine in thyroidectomy patients

Search NIH Clinical Center for Postsurgical Hypothyroidism

Genetic Tests for Postsurgical Hypothyroidism

Anatomical Context for Postsurgical Hypothyroidism

MalaCards organs/tissues related to Postsurgical Hypothyroidism:

41
Thyroid, Skin, T Cells

Publications for Postsurgical Hypothyroidism

Articles related to Postsurgical Hypothyroidism:

(show all 11)
# Title Authors Year
1
Clinical Features of Early and Late Postoperative Hypothyroidism After Lobectomy. ( 28324106 )
2017
2
The Effect of Levothyroxine Discontinuation Timing on Postoperative Hypothyroidism after Hemithyroidectomy for Papillary Thyroid Microcarcinoma. ( 27293432 )
2016
3
Early Cardiac Tamponade in a Patient with Postsurgical Hypothyroidism. ( 26294982 )
2015
4
Factors associated with postoperative hypothyroidism after lobectomy in papillary thyroid microcarcinoma patients. ( 25111668 )
2015
5
Thyroid function after unilateral total lobectomy: risk factors for postoperative hypothyroidism. ( 18936354 )
2008
6
NIS mRNA expression level in resected thyroid tissue as a marker of postoperative hypothyroidism after subtotal thyroidectomy in patients with Graves' disease. ( 18187871 )
2008
7
Emergency approach to psychosis in postoperative hypothyroidism. ( 17912160 )
2007
8
Trial of autotransplantation of cryopreserved thyroid tissue for postoperative hypothyroidism in patients with Graves' disease. ( 11800336 )
2002
9
Pathophysiology and predictivity of postoperative hypothyroidism. ( 3225175 )
1988
10
Histometry of lymphoid infiltrate in the thyroid of primary thyrotoxicosis patients. Relation of extent of thyroiditis to preoperative drug treatment and postoperative hypothyroidism. ( 932230 )
1976
11
An unusual case of malignant exophthalmos and postoperative hypothyroidism complicating Graves' disease. ( 13084736 )
1953

Variations for Postsurgical Hypothyroidism

Expression for Postsurgical Hypothyroidism

Search GEO for disease gene expression data for Postsurgical Hypothyroidism.

Pathways for Postsurgical Hypothyroidism

Pathways related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.58 TG TRH TSHR

GO Terms for Postsurgical Hypothyroidism

Biological processes related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to hydrogen peroxide GO:0042542 9.48 HP MB
2 hormone-mediated signaling pathway GO:0009755 9.46 TRH TSHR
3 potassium ion import across plasma membrane GO:1990573 9.43 ATP12A ATP4A
4 sodium ion transport GO:0006814 9.43 ATP12A ATP4A SCN8A
5 potassium ion import GO:0010107 9.4 ATP12A ATP4A
6 ATP hydrolysis coupled proton transport GO:0015991 9.37 ATP12A ATP4A
7 cellular sodium ion homeostasis GO:0006883 9.32 ATP12A ATP4A
8 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP12A ATP4A
9 cellular potassium ion homeostasis GO:0030007 8.96 ATP12A ATP4A
10 sodium ion export across plasma membrane GO:0036376 8.62 ATP12A ATP4A

Molecular functions related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Postsurgical Hypothyroidism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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