MCID: PST014
MIFTS: 35

Postsurgical Hypothyroidism

Categories: Endocrine diseases

Aliases & Classifications for Postsurgical Hypothyroidism

MalaCards integrated aliases for Postsurgical Hypothyroidism:

Name: Postsurgical Hypothyroidism 12 15
Postoperative Hypothyroidism 12 72
Post-Surgical Hypothyroidism 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1458
ICD9CM 35 244.0
SNOMED-CT 68 27059002
ICD10 33 E89.0
UMLS 72 C0154157

Summaries for Postsurgical Hypothyroidism

MalaCards based summary : Postsurgical Hypothyroidism, also known as postoperative hypothyroidism, is related to myxedema and hypothyroidism. An important gene associated with Postsurgical Hypothyroidism is GRHL3 (Grainyhead Like Transcription Factor 3), and among its related pathways/superpathways is Thyroxine (Thyroid Hormone) Production. The drugs Parathyroid hormone and Calcium have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and kidney, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Postsurgical Hypothyroidism

Diseases related to Postsurgical Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 myxedema 30.6 TSHR TG
2 hypothyroidism 30.6 TSHR TRH TG
3 papillary thyroid microcarcinoma 30.6 TSHR TG
4 graves disease 1 30.5 TSHR TRH TG
5 thyroiditis 30.5 TSHR TRH TG
6 hyperthyroidism 30.4 TSHR TRH TG
7 goiter 30.3 TSHR TRH TG
8 exophthalmos 30.1 TSHR TG
9 nodular goiter 30.0 TSHR TG
10 thyroid gland disease 30.0 TSHR TRH TG PTH
11 multinodular goiter 29.6 TSHR TG
12 substernal goiter 10.7 TG PTH
13 water-clear cell adenoma 10.7 TG PTH
14 clear cell adenoma 10.7 TG PTH
15 benign struma ovarii 10.6 TSHR TG
16 struma ovarii 10.6 TSHR TG
17 athyreosis 10.6 TSHR TG
18 hypothyroidism, congenital, nongoitrous, 2 10.6 TSHR TG
19 nontoxic goiter 10.6 TSHR TG
20 subacute thyroiditis 10.6 TSHR TG
21 thyroid hormone resistance, generalized, autosomal dominant 10.6 TRH TG
22 hyperthyroxinemia 10.5 TSHR TRH
23 thymus lipoma 10.4 PTH MB
24 cell type benign neoplasm 10.4 TRH TG PTH
25 endemic goiter 10.4 TSHR TG PTH
26 toxic diffuse goiter 10.4 TSHR TRH TG
27 hypothyroidism, congenital, nongoitrous, 4 10.4 TRH TG
28 chronic orbital inflammation 10.3 TSHR CSF3
29 thyroid crisis 10.3 TG PTH MB
30 autoimmune disease of endocrine system 10.2 TSHR TG
31 fungal esophagitis 10.1 ATP4A ATP12A
32 gastroduodenal crohn's disease 10.1 ATP4A ATP12A
33 diclofenac allergy 10.1 ATP4A ATP12A
34 neonatal candidiasis 10.1 ATP4A ATP12A
35 squamous papillomatosis 10.1 ATP4A ATP12A
36 photoallergic dermatitis 10.1 ATP4A ATP12A
37 gastrointestinal neuroendocrine benign tumor 10.1 ATP4A ATP12A
38 aspiration pneumonitis 10.1 ATP4A ATP12A
39 toxic megacolon 10.1 ATP4A ATP12A
40 granulomatous gastritis 10.1 ATP4A ATP12A
41 gastric antral vascular ectasia 10.1 ATP4A ATP12A
42 acute laryngitis 10.1 ATP4A ATP12A
43 laryngitis 10.1 ATP4A ATP12A
44 gastric neuroendocrine neoplasm 10.1 ATP4A ATP12A
45 esophageal candidiasis 10.1 ATP4A ATP12A
46 duodenitis 10.1 ATP4A ATP12A
47 active peptic ulcer disease 10.1 ATP4A ATP12A
48 rumination disorder 10.1 ATP4A ATP12A
49 dyskinesia of esophagus 10.1 ATP4A ATP12A
50 peptic esophagitis 10.1 ATP4A ATP12A

Comorbidity relations with Postsurgical Hypothyroidism via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypoparathyroidism
Hypothyroidism Intermediate Coronary Syndrome
Mitral Valve Disease Osteoporosis

Graphical network of the top 20 diseases related to Postsurgical Hypothyroidism:



Diseases related to Postsurgical Hypothyroidism

Symptoms & Phenotypes for Postsurgical Hypothyroidism

MGI Mouse Phenotypes related to Postsurgical Hypothyroidism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 ATP4A AURKA CSF3 GRHL3 HP MB
2 homeostasis/metabolism MP:0005376 9.61 ATP12A ATP4A GRHL3 HP MB PTH
3 neoplasm MP:0002006 9.02 ATP4A AURKA GRHL3 HP TSHR

Drugs & Therapeutics for Postsurgical Hypothyroidism

Drugs for Postsurgical Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Parathyroid hormone Approved, Investigational 9002-64-6
2
Calcium Approved, Nutraceutical 7440-70-2 271
3 Calcium, Dietary
4 Hormones
5 Hormone Antagonists
6 Hormones, Hormone Substitutes, and Hormone Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ThyrOp: Individual Subclinical Hypothyroidism After Hemithyroidectomy for Benign Nontoxic Goiter - Focus on Weight Gain and Mitochondrial Dysfunction Unknown status NCT01358136
2 Phase 1 Study of Electrical Impedance Spectroscopy in Thyroid and Parathyroid Surgery Completed NCT02901873
3 Is Levothyroxine Alone Adequate Thyroid Hormone Replacement for All Patients? Recruiting NCT02567877 levothyroxine in thyroidectomy patients

Search NIH Clinical Center for Postsurgical Hypothyroidism

Genetic Tests for Postsurgical Hypothyroidism

Anatomical Context for Postsurgical Hypothyroidism

MalaCards organs/tissues related to Postsurgical Hypothyroidism:

41
Thyroid, Testes, Kidney, Lymph Node, Pituitary

Publications for Postsurgical Hypothyroidism

Articles related to Postsurgical Hypothyroidism:

(show top 50) (show all 133)
# Title Authors PMID Year
1
Adequate restitution in primary hypothyroidism depending on levothyroxine formulations 38
30376277 2018
2
Relationship between perioperative thyroid function and acute kidney injury after thyroidectomy. 38
30201973 2018
3
Prevalence of hypothyroidism among patients with isthmus-preserved thyroid lobectomy. 38
29968481 2018
4
Hypothyroidism and Wound Healing After Salvage Laryngectomy. 38
29264671 2018
5
Pancytopenia: a rare complication of Graves' disease. 38
29525760 2018
6
Severe Hyperthyroidism Complicated by Agranulocytosis Treated with Therapeutic Plasma Exchange: Case Report and Review of the Literature. 38
29552362 2018
7
[Hypothyreosis after Hemithyroidectomy - surprisingly frequent complication in aftercare]. 38
28597456 2018
8
Review of Heterotopic Thyroid Autotransplantation. 38
28535579 2017
9
Effect of Thyroid Remnant Volume on the Risk of Hypothyroidism After Hemithyroidectomy: A Prospective Study. 38
28058547 2017
10
Comparison of endoscopic and conventional open thyroidectomy for Graves' disease: A meta-analysis. 38
28235670 2017
11
Clinical Features of Early and Late Postoperative Hypothyroidism After Lobectomy. 38
28324106 2017
12
Thyroid Surgery in a Resource-Limited Setting. 38
28025932 2017
13
Concurrent Hypoparathyroidism Is Associated With Impaired Physical Function and Quality of Life in Hypothyroidism. 38
26865527 2016
14
[Cytoflavin rationale for the use in treatment of patients with postsurgical hypothyroidism]. 38
27459489 2016
15
The Effect of Levothyroxine Discontinuation Timing on Postoperative Hypothyroidism after Hemithyroidectomy for Papillary Thyroid Microcarcinoma. 38
27293432 2016
16
Experimental autotransplantation and cryopreservation of the thyroid gland. 38
24634027 2015
17
Early severe fetal Graves disease in a mother after thyroid ablation and thyroidectomy. 38
25710616 2015
18
Factors associated with postoperative hypothyroidism after lobectomy in papillary thyroid microcarcinoma patients. 38
25111668 2015
19
Early Cardiac Tamponade in a Patient with Postsurgical Hypothyroidism. 38
26294982 2015
20
Prediction of thyroid hormone supplementation after thyroid lobectomy. 38
25088372 2015
21
Prospective analysis of risk for hypothyroidism after hemithyroidectomy. 38
25918526 2015
22
[Postoperative hypothyroidism]. 38
25962288 2015
23
Changes in body weight after treatment of primary hypothyroidism with levothyroxine. 38
24936556 2014
24
Highlights in thyroidology: a historical vignette. 38
24652010 2014
25
Clinical effectiveness of thyroidectomy on the management of locally advanced laryngeal cancer. 38
24176487 2014
26
[Risk factors for renal dysfunction in patients with hypothyroidism]. 38
25796821 2014
27
Are levothyroxine requirements lower in thyroidectomized diabetic patients on metformin treatment? 38
23758637 2013
28
Papillary thyroid carcinoma with thyroiditis: lymph node metastasis, complications. 38
23833756 2013
29
Thyroid hormone replacement therapy, surveillance ultrasonography, and fine-needle aspiration after hemithyroidectomy. 38
23951697 2013
30
Levothyroxine replacement dosage determination after thyroidectomy. 38
23369308 2013
31
What is the best definitive treatment for Graves' disease? A systematic review of the existing literature. 38
22956065 2013
32
Selective or radical surgical strategy in functional autonomy of the thyroid in endemic areas. 38
24151744 2013
33
Hemithyroidectomy: a meta-analysis of postoperative need for hormone replacement and complications. 38
23486083 2013
34
Risk of hypothyroidism following hemithyroidectomy: systematic review and meta-analysis of prognostic studies. 38
22511795 2012
35
Thyroid function after subtotal thyroidectomy in patients with Graves' hyperthyroidism. 38
22448136 2012
36
Weight changes in euthyroid patients undergoing thyroidectomy. 38
22066482 2011
37
Detection and management of hypothyroidism following thyroid lobectomy: evaluation of a clinical algorithm. 38
21547704 2011
38
Subclinical hypothyroidism following hemithyroidectomy: a simple risk-scoring system using age and preoperative thyrotropin level. 38
21212713 2011
39
Successful treatment of postsurgical hypoparathyroidism by intramuscular injection of vitamin D3 in a patient associated with malabsorption syndrome due to multiple abdominal surgeries. 38
19657589 2010
40
Hypothyroidism following hemithyroidectomy: a retrospective review. 38
19779329 2009
41
Thyroid hormone replacement after thyroid lobectomy. 38
19789012 2009
42
What constitutes adequate surgical therapy for benign nodular goiter? 38
18952235 2009
43
[The method of toxic goiter surgical treatment]. 38
19491772 2009
44
Thyrotropin level and thyroid volume for prediction of hypothyroidism following hemithyroidectomy in an Asian patient cohort. 38
18758850 2008
45
Thyroid function after unilateral total lobectomy: risk factors for postoperative hypothyroidism. 38
18936354 2008
46
Hypothyrodism in male patients: a descriptive, observational and cross-sectional study in a series of 260 men. 38
18854673 2008
47
Prediction of hypothyroidism after hemithyroidectomy: a biochemical and pathological analysis. 38
17978827 2008
48
NIS mRNA expression level in resected thyroid tissue as a marker of postoperative hypothyroidism after subtotal thyroidectomy in patients with Graves' disease. 38
18187871 2008
49
Surgical treatment of Graves' disease: subtotal thyroidectomy might still be the preferred option. 38
18277085 2008
50
[Rhabdomyolysis in a patient with postoperative hypothyroidism and hypoparathyroidism]. 38
18318245 2008

Variations for Postsurgical Hypothyroidism

Expression for Postsurgical Hypothyroidism

Search GEO for disease gene expression data for Postsurgical Hypothyroidism.

Pathways for Postsurgical Hypothyroidism

Pathways related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.58 TSHR TRH TG

GO Terms for Postsurgical Hypothyroidism

Biological processes related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.63 TSHR TRH PTH
2 potassium ion import across plasma membrane GO:1990573 9.43 ATP4A ATP12A
3 ATP hydrolysis coupled proton transport GO:0015991 9.4 ATP4A ATP12A
4 cochlea morphogenesis GO:0090103 9.37 TSHR GRHL3
5 response to ethanol GO:0045471 9.33 TRH PTH CSF3
6 cellular sodium ion homeostasis GO:0006883 9.32 ATP4A ATP12A
7 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.26 ATP4A ATP12A
8 sodium ion export across plasma membrane GO:0036376 8.96 ATP4A ATP12A
9 cellular potassium ion homeostasis GO:0030007 8.62 ATP4A ATP12A

Molecular functions related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.33 TRH TG PTH
2 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Postsurgical Hypothyroidism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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