MCID: PST014
MIFTS: 30

Postsurgical Hypothyroidism

Categories: Endocrine diseases

Aliases & Classifications for Postsurgical Hypothyroidism

MalaCards integrated aliases for Postsurgical Hypothyroidism:

Name: Postsurgical Hypothyroidism 12 15
Postoperative Hypothyroidism 12 71
Post-Surgical Hypothyroidism 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1458
ICD9CM 34 244.0
SNOMED-CT 67 27059002
ICD10 32 E89.0
UMLS 71 C0154157

Summaries for Postsurgical Hypothyroidism

MalaCards based summary : Postsurgical Hypothyroidism, also known as postoperative hypothyroidism, is related to thyroiditis and papillary thyroid microcarcinoma. An important gene associated with Postsurgical Hypothyroidism is TG (Thyroglobulin), and among its related pathways/superpathways is Thyroxine (Thyroid Hormone) Production. The drugs Parathyroid hormone and Calcium have been mentioned in the context of this disorder. Affiliated tissues include thyroid, kidney and t cells.

Related Diseases for Postsurgical Hypothyroidism

Diseases related to Postsurgical Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 thyroiditis 30.1 TSHR TG
2 papillary thyroid microcarcinoma 30.1 TSHR TG
3 myxedema 29.9 TSHR TG
4 thyroid carcinoma 29.8 TSHR TG
5 nodular goiter 29.8 TSHR TG
6 graves disease 1 29.7 TSHR TG PTH
7 hyperthyroidism 29.6 TSHR TG PTH
8 multinodular goiter 29.6 TSHR TG PTH
9 exophthalmos 29.5 TSHR TG
10 hypothyroidism 29.0 TUBB1 TSHR TG FOXE1
11 thyroid gland disease 28.6 TSHR TG PTH FOXE1
12 substernal goiter 10.2 TG PTH
13 clear cell adenoma 10.2 TG PTH
14 tall cell variant papillary carcinoma 10.2 TG PTH
15 iodine hypothyroidism 10.2 TSHR TG
16 thyroid crisis 10.1 TSHR TG
17 toxic diffuse goiter 10.1 TSHR TG
18 neonatal thyrotoxicosis 10.1 TSHR TG
19 subacute lymphocytic thyroiditis 10.1 TSHR TG
20 benign struma ovarii 10.1 TSHR TG
21 struma ovarii 10.1 TSHR TG
22 plummer's disease 10.1 TSHR TG
23 orbital disease 10.1 TSHR TG
24 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1 TSHR TG
25 tubulin, beta 10.1 TUBB8 TUBB1
26 parathyroid gland disease 10.0 TG PTH
27 thyroid hormone resistance, generalized, autosomal dominant 10.0 TSHR TG
28 subacute thyroiditis 10.0 TSHR TG
29 graves' disease 10.0
30 chondrodysplasia, blomstrand type 10.0 TSHR PTH
31 thyroid gland follicular carcinoma 10.0 TSHR TG
32 thyroid cancer, nonmedullary, 2 9.9 TSHR TG
33 endemic goiter 9.9 TSHR TG PTH
34 nontoxic goiter 9.9 TSHR TG PTH
35 hypoparathyroidism 9.9
36 hemopericardium 9.9
37 cardiac tamponade 9.9
38 pericardial effusion 9.9
39 galactorrhea 9.9
40 goiter 9.9
41 amenorrhea 9.9
42 autoimmune disease of endocrine system 9.9 TSHR TG PTH
43 follicular adenoma 9.9 TSHR TG
44 primary congenital hypothyroidism 9.8 TSHR FOXE1
45 endocrine organ benign neoplasm 9.7 TG PTH
46 autoimmune disease 9.7
47 pendred syndrome 9.7
48 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 9.7
49 acute kidney failure 9.7
50 adenoma 9.7

Comorbidity relations with Postsurgical Hypothyroidism via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypoparathyroidism
Hypothyroidism Intermediate Coronary Syndrome
Mitral Valve Disease Osteoporosis

Graphical network of the top 20 diseases related to Postsurgical Hypothyroidism:



Diseases related to Postsurgical Hypothyroidism

Symptoms & Phenotypes for Postsurgical Hypothyroidism

Drugs & Therapeutics for Postsurgical Hypothyroidism

Drugs for Postsurgical Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Parathyroid hormone Approved, Investigational 9002-64-6
2
Calcium Approved, Nutraceutical 7440-70-2 271
3 Calcium, Dietary
4 Hormones
5 Hormone Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ThyrOp: Individual Subclinical Hypothyroidism After Hemithyroidectomy for Benign Nontoxic Goiter - Focus on Weight Gain and Mitochondrial Dysfunction Unknown status NCT01358136
2 Phase 1 Study of Electrical Impedance Spectroscopy in Thyroid and Parathyroid Surgery Completed NCT02901873
3 Is Levothyroxine Alone Adequate Thyroid Hormone Replacement for All Patients? Recruiting NCT02567877 levothyroxine in thyroidectomy patients

Search NIH Clinical Center for Postsurgical Hypothyroidism

Genetic Tests for Postsurgical Hypothyroidism

Anatomical Context for Postsurgical Hypothyroidism

MalaCards organs/tissues related to Postsurgical Hypothyroidism:

40
Thyroid, Kidney, T Cells, Lymph Node, Testes, Pituitary

Publications for Postsurgical Hypothyroidism

Articles related to Postsurgical Hypothyroidism:

(show top 50) (show all 139)
# Title Authors PMID Year
1
Oncological impact of hypothyroidism and levothyroxine supplementation following hemithyroidectomy in patients with papillary thyroid carcinoma. 61
31930773 2020
2
The Role of Serum Procalcitonin in Predicting Bacterial Sepsis in Patients With Hypothyroidism. 61
31361312 2019
3
Treatment of patients with Graves' disease and the appropriate extent of thyroidectomy. 61
31530446 2019
4
Presentation, Morbidity and Treatment Outcome of Acromegaly Patients at a Single Centre. 61
31741902 2019
5
Management of Subclinical and Overt Hypothyroidism Following Hemithyroidectomy in Children and Adolescents: A Pilot Study. 61
31612123 2019
6
Incidences of Hypothyroidism Associated With Surgical Procedures for Thyroid Disorders: A Nationwide Population-Based Study. 61
31920634 2019
7
Adequate restitution in primary hypothyroidism depending on levothyroxine formulations 61
30376277 2018
8
Relationship between perioperative thyroid function and acute kidney injury after thyroidectomy. 61
30201973 2018
9
Prevalence of hypothyroidism among patients with isthmus-preserved thyroid lobectomy. 61
29968481 2018
10
Hypothyroidism and Wound Healing After Salvage Laryngectomy. 61
29264671 2018
11
Pancytopenia: a rare complication of Graves' disease. 61
29525760 2018
12
Severe Hyperthyroidism Complicated by Agranulocytosis Treated with Therapeutic Plasma Exchange: Case Report and Review of the Literature. 61
29552362 2018
13
[Hypothyreosis after Hemithyroidectomy - surprisingly frequent complication in aftercare]. 61
28597456 2018
14
Review of Heterotopic Thyroid Autotransplantation. 61
28535579 2017
15
Effect of Thyroid Remnant Volume on the Risk of Hypothyroidism After Hemithyroidectomy: A Prospective Study. 61
28058547 2017
16
Comparison of endoscopic and conventional open thyroidectomy for Graves' disease: A meta-analysis. 61
28235670 2017
17
Clinical Features of Early and Late Postoperative Hypothyroidism After Lobectomy. 61
28324106 2017
18
Thyroid Surgery in a Resource-Limited Setting. 61
28025932 2017
19
Concurrent Hypoparathyroidism Is Associated With Impaired Physical Function and Quality of Life in Hypothyroidism. 61
26865527 2016
20
The Effect of Levothyroxine Discontinuation Timing on Postoperative Hypothyroidism after Hemithyroidectomy for Papillary Thyroid Microcarcinoma. 61
27293432 2016
21
[Cytoflavin rationale for the use in treatment of patients with postsurgical hypothyroidism]. 61
27459489 2016
22
Experimental autotransplantation and cryopreservation of the thyroid gland. 61
24634027 2015
23
Early severe fetal Graves disease in a mother after thyroid ablation and thyroidectomy. 61
25710616 2015
24
Factors associated with postoperative hypothyroidism after lobectomy in papillary thyroid microcarcinoma patients. 61
25111668 2015
25
Early Cardiac Tamponade in a Patient with Postsurgical Hypothyroidism. 61
26294982 2015
26
Prediction of thyroid hormone supplementation after thyroid lobectomy. 61
25088372 2015
27
Prospective analysis of risk for hypothyroidism after hemithyroidectomy. 61
25918526 2015
28
[Postoperative hypothyroidism]. 61
25962288 2015
29
Changes in body weight after treatment of primary hypothyroidism with levothyroxine. 61
24936556 2014
30
Highlights in thyroidology: a historical vignette. 61
24652010 2014
31
Clinical effectiveness of thyroidectomy on the management of locally advanced laryngeal cancer. 61
24176487 2014
32
[Risk factors for renal dysfunction in patients with hypothyroidism]. 61
25796821 2014
33
Are levothyroxine requirements lower in thyroidectomized diabetic patients on metformin treatment? 61
23758637 2013
34
Papillary thyroid carcinoma with thyroiditis: lymph node metastasis, complications. 61
23833756 2013
35
Thyroid hormone replacement therapy, surveillance ultrasonography, and fine-needle aspiration after hemithyroidectomy. 61
23951697 2013
36
Levothyroxine replacement dosage determination after thyroidectomy. 61
23369308 2013
37
What is the best definitive treatment for Graves' disease? A systematic review of the existing literature. 61
22956065 2013
38
Selective or radical surgical strategy in functional autonomy of the thyroid in endemic areas. 61
24151744 2013
39
Hemithyroidectomy: a meta-analysis of postoperative need for hormone replacement and complications. 61
23486083 2013
40
Risk of hypothyroidism following hemithyroidectomy: systematic review and meta-analysis of prognostic studies. 61
22511795 2012
41
Thyroid function after subtotal thyroidectomy in patients with Graves' hyperthyroidism. 61
22448136 2012
42
Weight changes in euthyroid patients undergoing thyroidectomy. 61
22066482 2011
43
Detection and management of hypothyroidism following thyroid lobectomy: evaluation of a clinical algorithm. 61
21547704 2011
44
Subclinical hypothyroidism following hemithyroidectomy: a simple risk-scoring system using age and preoperative thyrotropin level. 61
21212713 2011
45
Successful treatment of postsurgical hypoparathyroidism by intramuscular injection of vitamin D3 in a patient associated with malabsorption syndrome due to multiple abdominal surgeries. 61
19657589 2010
46
Hypothyroidism following hemithyroidectomy: a retrospective review. 61
19779329 2009
47
Thyroid hormone replacement after thyroid lobectomy. 61
19789012 2009
48
What constitutes adequate surgical therapy for benign nodular goiter? 61
18952235 2009
49
[The method of toxic goiter surgical treatment]. 61
19491772 2009
50
Thyrotropin level and thyroid volume for prediction of hypothyroidism following hemithyroidectomy in an Asian patient cohort. 61
18758850 2008

Variations for Postsurgical Hypothyroidism

Expression for Postsurgical Hypothyroidism

Search GEO for disease gene expression data for Postsurgical Hypothyroidism.

Pathways for Postsurgical Hypothyroidism

Pathways related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.4 TSHR TG

GO Terms for Postsurgical Hypothyroidism

Biological processes related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule-based process GO:0007017 9.16 TUBB8 TUBB1
2 thyroid gland development GO:0030878 8.96 TG FOXE1
3 cochlea morphogenesis GO:0090103 8.62 TSHR GRHL3

Sources for Postsurgical Hypothyroidism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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