Postsurgical Hypothyroidism disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Postsurgical Hypothyroidism

MalaCards integrated aliases for Postsurgical Hypothyroidism:

Name: Postsurgical Hypothyroidism ¹² ¹⁵

Postoperative Hypothyroidism ¹² ⁷⁴

Post-Surgical Hypothyroidism ¹²

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Endocrine, nutritional and metabolic diseases

Metabolic disorders

Postprocedural endocrine and metabolic disorders, not elsewhere classified

Postprocedural hypothyroidism

External Ids:

Disease Ontology ¹² DOID:1458

ICD9CM ³⁶ 244.0

SNOMED-CT ⁶⁹ 27059002

ICD10 ³⁴ E89.0

UMLS ⁷⁴ C0154157

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Summaries for Postsurgical Hypothyroidism

MalaCards based summary : Postsurgical Hypothyroidism, also known as postoperative hypothyroidism, is related to papillary thyroid microcarcinoma and hypothyroidism. An important gene associated with Postsurgical Hypothyroidism is TG (Thyroglobulin), and among its related pathways/superpathways are amb2 Integrin signaling and Thyroxine (Thyroid Hormone) Production. The drugs Parathyroid hormone and Calcium have been mentioned in the context of this disorder. Affiliated tissues include thyroid, and related phenotype is hematopoietic system.

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Related Diseases for Postsurgical Hypothyroidism

Diseases related to Postsurgical Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)

#	Related Disease	Score	Top Affiliating Genes
1	papillary thyroid microcarcinoma	30.2	TG TSHR
2	hypothyroidism	30.1	TG TRH TSHR
3	exophthalmos	29.9	TG TSHR
4	goiter	29.8	TG TRH TSHR
5	graves disease 1	29.8	TG TRH TSHR
6	thyroiditis	29.8	TG TRH TSHR
7	nodular goiter	29.8	TG TSHR
8	substernal goiter	10.4	PTH TG
9	water-clear cell adenoma	10.4	PTH TG
10	clear cell adenoma	10.4	PTH TG
11	benign struma ovarii	10.4	TG TSHR
12	struma ovarii	10.4	TG TSHR
13	neonatal hypothyroidism	10.4	TG TSHR
14	athyreosis	10.4	TG TSHR
15	hypothyroidism, congenital, nongoitrous, 2	10.4	TG TSHR
16	thyroid hormone resistance, generalized, autosomal dominant	10.4	TG TRH
17	nontoxic goiter	10.4	TG TSHR
18	myxedema	10.4	TG TSHR
19	subacute thyroiditis	10.3	TG TSHR
20	hyperthyroxinemia	10.3	TRH TSHR
21	thymus lipoma	10.3	MB PTH
22	cell type benign neoplasm	10.2	PTH TG TRH
23	hypothyroidism, congenital, nongoitrous, 4	10.2	TG TRH
24	endemic goiter	10.2	PTH TG TSHR
25	toxic diffuse goiter	10.2	TG TRH TSHR
26	hyperthyroidism	10.2	TG TRH TSHR
27	chronic orbital inflammation	10.2	CSF3 TSHR
28	thyroid crisis	10.2	MB PTH TG
29	alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity	10.2	TG TSHR
30	autoimmune disease of endocrine system	10.2	TG TSHR
31	multinodular goiter	10.1	TG TSHR
32	fungal esophagitis	10.1	ATP12A ATP4A
33	diclofenac allergy	10.1	ATP12A ATP4A
34	gastroduodenal crohn's disease	10.1	ATP12A ATP4A
35	neonatal candidiasis	10.1	ATP12A ATP4A
36	photoallergic dermatitis	10.1	ATP12A ATP4A
37	squamous papillomatosis	10.1	ATP12A ATP4A
38	toxic megacolon	10.1	ATP12A ATP4A
39	aspiration pneumonitis	10.1	ATP12A ATP4A
40	gastrointestinal neuroendocrine benign tumor	10.1	ATP12A ATP4A
41	gastric antral vascular ectasia	10.1	ATP12A ATP4A
42	granulomatous gastritis	10.1	ATP12A ATP4A
43	thyroid gland disease	10.1	PTH TG TRH TSHR
44	esophageal candidiasis	10.1	ATP12A ATP4A
45	gastric neuroendocrine neoplasm	10.1	ATP12A ATP4A
46	acute laryngitis	10.1	ATP12A ATP4A
47	laryngitis	10.1	ATP12A ATP4A
48	duodenitis	10.1	ATP12A ATP4A
49	rumination disorder	10.1	ATP12A ATP4A
50	active peptic ulcer disease	10.1	ATP12A ATP4A

Comorbidity relations with Postsurgical Hypothyroidism via Phenotypic Disease Network (PDN): (show all 12)

Acute Cystitis	Deficiency Anemia
Familial Atrial Fibrillation	Heart Disease
Hypertension, Essential	Hypoparathyroidism
Hypothyroidism	Intermediate Coronary Syndrome
Ischemic Heart Disease	Mitral Valve Disease
Osteoporosis	Thyroid Cancer

Graphical network of the top 20 diseases related to Postsurgical Hypothyroidism:

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Symptoms & Phenotypes for Postsurgical Hypothyroidism

MGI Mouse Phenotypes related to Postsurgical Hypothyroidism:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.23	ATP4A AURKA CSF3 HP MB PTH

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Drugs & Therapeutics for Postsurgical Hypothyroidism

Drugs for Postsurgical Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Parathyroid hormone

Approved, Investigational

Not Applicable

9002-64-6

Synonyms:

Parathormone

Parathormone (human recombinant)

Parathyrin

Parathyroid hormone

Parathyroid hormone (1-84) human recombinant

Parathyroid hormone (rDNA)

PTH

PTH(1-84)

rhPTH

rhPTH(1-84)

rPTH

rPTH(1-84)

2

Calcium

Approved, Nutraceutical

Not Applicable

7440-70-2

271

Synonyms:

Blood coagulation factor XIII

Ca

Ca(2+)

Ca2+

Calcio

Calcium

Calcium element

CALCIUM ion

Calcium, doubly charged positive ion

Calcium, elemental

Coagulation factor XIII

Elemental calcium

Factor XIII

Factor XIII a chain

Factor XIII a-chain

Factor XIII transamidase

Factor XIII, coagulation

Fibrin stabilizing factor

Fibrinase

Kalzium

Laki lorand factor

Laki-lorand factor

Stabilizing factor, fibrin

Transamidase, factor XIII

XIII, coagulation factor

3

Hormones

Not Applicable

4

Calcium, Dietary

Not Applicable

5

Hormones, Hormone Substitutes, and Hormone Antagonists

6

Hormone Antagonists

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Levothyroxine Replacement With Liquid Gel Capsules vs Tablets Post-thyroidectomy	Recruiting	NCT02946918	Phase 4	Levothyroxine
2	Levothyroxine Treatment for Subclinical Hypothyroidism After Head and Neck Surgery	Unknown status	NCT02548715	Phase 2, Phase 3	Levothyroxine;Placebo
3	EIS in Thyroid and Parathyroid Surgery	Completed	NCT02901873	Not Applicable
4	Is Levothyroxine Alone Adequate Thyroid Hormone Replacement?	Recruiting	NCT02567877		levothyroxine in thyroidectomy patients

Search NIH Clinical Center for Postsurgical Hypothyroidism

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Genetic Tests for Postsurgical Hypothyroidism

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Anatomical Context for Postsurgical Hypothyroidism

MalaCards organs/tissues related to Postsurgical Hypothyroidism:

⁴²

Thyroid

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Publications for Postsurgical Hypothyroidism

Articles related to Postsurgical Hypothyroidism:

(show all 12)

#	Title	Authors	Year
1	Clinical Features of Early and Late Postoperative Hypothyroidism After Lobectomy. ( 28324106 )	Park S...Kim WG	2017
2	The Effect of Levothyroxine Discontinuation Timing on Postoperative Hypothyroidism after Hemithyroidectomy for Papillary Thyroid Microcarcinoma. ( 27293432 )	Ha TK...Ahn KJ	2016
3	Early Cardiac Tamponade in a Patient with Postsurgical Hypothyroidism. ( 26294982 )	Sinha A....Curry B.H.	2015
4	Factors associated with postoperative hypothyroidism after lobectomy in papillary thyroid microcarcinoma patients. ( 25111668 )	Park HK...Bae SK	2015
5	Thyroid function after unilateral total lobectomy: risk factors for postoperative hypothyroidism. ( 18936354 )	De Carlucci D....Cernea C.R.	2008
6	NIS mRNA expression level in resected thyroid tissue as a marker of postoperative hypothyroidism after subtotal thyroidectomy in patients with Graves' disease. ( 18187871 )	Goto A....Onji M.	2008
7	Emergency approach to psychosis in postoperative hypothyroidism. ( 17912160 )	Colombo GM...Cicchinelli M	2007
8	[Postoperative hypothyroidism in patients with multi-nodular goiter]. ( 12953431 )	Saidova F.K.h.	2003
9	Trial of autotransplantation of cryopreserved thyroid tissue for postoperative hypothyroidism in patients with Graves' disease. ( 11800336 )	Shimizu K...Tanaka S	2002
10	Pathophysiology and predictivity of postoperative hypothyroidism. ( 3225175 )	Manfredi A...Goffrini PA	1988
11	Histometry of lymphoid infiltrate in the thyroid of primary thyrotoxicosis patients. Relation of extent of thyroiditis to preoperative drug treatment and postoperative hypothyroidism. ( 932230 )	Young RJ...Beck JS	1976
12	An unusual case of malignant exophthalmos and postoperative hypothyroidism complicating Graves' disease. ( 13084736 )	ENGEL FL	1953

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Genes for Postsurgical Hypothyroidism

Genes related to Postsurgical Hypothyroidism (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TG	Thyroglobulin	Protein Coding	15.63	DISEASES inferred ¹⁵
2	PTH	Parathyroid Hormone	Protein Coding	14.53	DISEASES inferred ¹⁵
3	TRH	Thyrotropin Releasing Hormone	Protein Coding	14.47	DISEASES inferred ¹⁵
4	TSHR	Thyroid Stimulating Hormone Receptor	Protein Coding	14.25	DISEASES inferred ¹⁵
5	AURKA	Aurora Kinase A	Protein Coding	14.12	DISEASES inferred ¹⁵
6	MB	Myoglobin	Protein Coding	13.81	DISEASES inferred ¹⁵
7	HP	Haptoglobin	Protein Coding	13.63	DISEASES inferred ¹⁵
8	LPA	Lipoprotein(A)	Protein Coding	13.45	DISEASES inferred ¹⁵
9	ATP12A	ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit	Protein Coding	13.18	DISEASES inferred ¹⁵
10	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	13.18	DISEASES inferred ¹⁵
11	LXN	Latexin	Protein Coding	5.34	DISEASES inferred ¹⁵
12	CSF3	Colony Stimulating Factor 3	Protein Coding	3.04	DISEASES inferred ¹⁵

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Variations for Postsurgical Hypothyroidism

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Expression for Postsurgical Hypothyroidism

Search GEO for disease gene expression data for Postsurgical Hypothyroidism.

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Pathways for Postsurgical Hypothyroidism

Pathways related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	amb2 Integrin signaling ¹	10.64	HP LPA
2	Thyroxine (Thyroid Hormone) Production ¹	9.58	TG TRH TSHR

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GO Terms for Postsurgical Hypothyroidism

Biological processes related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of signaling receptor activity	GO:0010469	9.67	CSF3 PTH TG TRH
2	cell-cell signaling	GO:0007267	9.61	PTH TRH TSHR
3	potassium ion import across plasma membrane	GO:1990573	9.46	ATP12A ATP4A
4	ATP hydrolysis coupled proton transport	GO:0015991	9.4	ATP12A ATP4A
5	response to ethanol	GO:0045471	9.33	CSF3 PTH TRH
6	cellular sodium ion homeostasis	GO:0006883	9.32	ATP12A ATP4A
7	establishment or maintenance of transmembrane electrochemical gradient	GO:0010248	9.26	ATP12A ATP4A
8	cellular potassium ion homeostasis	GO:0030007	8.96	ATP12A ATP4A
9	sodium ion export across plasma membrane	GO:0036376	8.62	ATP12A ATP4A

Molecular functions related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	9.33	PTH TG TRH
2	sodium:potassium-exchanging ATPase activity	GO:0005391	8.96	ATP12A ATP4A
3	potassium:proton exchanging ATPase activity	GO:0008900	8.62	ATP12A ATP4A

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Sources for Postsurgical Hypothyroidism

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