MCID: PST014
MIFTS: 30

Postsurgical Hypothyroidism

Categories: Endocrine diseases

Aliases & Classifications for Postsurgical Hypothyroidism

MalaCards integrated aliases for Postsurgical Hypothyroidism:

Name: Postsurgical Hypothyroidism 12 15
Postoperative Hypothyroidism 12 74
Post-Surgical Hypothyroidism 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1458
ICD9CM 36 244.0
SNOMED-CT 69 27059002
ICD10 34 E89.0
UMLS 74 C0154157

Summaries for Postsurgical Hypothyroidism

MalaCards based summary : Postsurgical Hypothyroidism, also known as postoperative hypothyroidism, is related to papillary thyroid microcarcinoma and hypothyroidism. An important gene associated with Postsurgical Hypothyroidism is TG (Thyroglobulin), and among its related pathways/superpathways are amb2 Integrin signaling and Thyroxine (Thyroid Hormone) Production. The drugs Parathyroid hormone and Calcium have been mentioned in the context of this disorder. Affiliated tissues include thyroid, and related phenotype is hematopoietic system.

Related Diseases for Postsurgical Hypothyroidism

Diseases related to Postsurgical Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 papillary thyroid microcarcinoma 30.2 TG TSHR
2 hypothyroidism 30.1 TG TRH TSHR
3 exophthalmos 29.9 TG TSHR
4 goiter 29.8 TG TRH TSHR
5 graves disease 1 29.8 TG TRH TSHR
6 thyroiditis 29.8 TG TRH TSHR
7 nodular goiter 29.8 TG TSHR
8 substernal goiter 10.4 PTH TG
9 water-clear cell adenoma 10.4 PTH TG
10 clear cell adenoma 10.4 PTH TG
11 benign struma ovarii 10.4 TG TSHR
12 struma ovarii 10.4 TG TSHR
13 neonatal hypothyroidism 10.4 TG TSHR
14 athyreosis 10.4 TG TSHR
15 hypothyroidism, congenital, nongoitrous, 2 10.4 TG TSHR
16 thyroid hormone resistance, generalized, autosomal dominant 10.4 TG TRH
17 nontoxic goiter 10.4 TG TSHR
18 myxedema 10.4 TG TSHR
19 subacute thyroiditis 10.3 TG TSHR
20 hyperthyroxinemia 10.3 TRH TSHR
21 thymus lipoma 10.3 MB PTH
22 cell type benign neoplasm 10.2 PTH TG TRH
23 hypothyroidism, congenital, nongoitrous, 4 10.2 TG TRH
24 endemic goiter 10.2 PTH TG TSHR
25 toxic diffuse goiter 10.2 TG TRH TSHR
26 hyperthyroidism 10.2 TG TRH TSHR
27 chronic orbital inflammation 10.2 CSF3 TSHR
28 thyroid crisis 10.2 MB PTH TG
29 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2 TG TSHR
30 autoimmune disease of endocrine system 10.2 TG TSHR
31 multinodular goiter 10.1 TG TSHR
32 fungal esophagitis 10.1 ATP12A ATP4A
33 diclofenac allergy 10.1 ATP12A ATP4A
34 gastroduodenal crohn's disease 10.1 ATP12A ATP4A
35 neonatal candidiasis 10.1 ATP12A ATP4A
36 photoallergic dermatitis 10.1 ATP12A ATP4A
37 squamous papillomatosis 10.1 ATP12A ATP4A
38 toxic megacolon 10.1 ATP12A ATP4A
39 aspiration pneumonitis 10.1 ATP12A ATP4A
40 gastrointestinal neuroendocrine benign tumor 10.1 ATP12A ATP4A
41 gastric antral vascular ectasia 10.1 ATP12A ATP4A
42 granulomatous gastritis 10.1 ATP12A ATP4A
43 thyroid gland disease 10.1 PTH TG TRH TSHR
44 esophageal candidiasis 10.1 ATP12A ATP4A
45 gastric neuroendocrine neoplasm 10.1 ATP12A ATP4A
46 acute laryngitis 10.1 ATP12A ATP4A
47 laryngitis 10.1 ATP12A ATP4A
48 duodenitis 10.1 ATP12A ATP4A
49 rumination disorder 10.1 ATP12A ATP4A
50 active peptic ulcer disease 10.1 ATP12A ATP4A

Comorbidity relations with Postsurgical Hypothyroidism via Phenotypic Disease Network (PDN): (show all 12)


Acute Cystitis Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypoparathyroidism
Hypothyroidism Intermediate Coronary Syndrome
Ischemic Heart Disease Mitral Valve Disease
Osteoporosis Thyroid Cancer

Graphical network of the top 20 diseases related to Postsurgical Hypothyroidism:



Diseases related to Postsurgical Hypothyroidism

Symptoms & Phenotypes for Postsurgical Hypothyroidism

MGI Mouse Phenotypes related to Postsurgical Hypothyroidism:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.23 ATP4A AURKA CSF3 HP MB PTH

Drugs & Therapeutics for Postsurgical Hypothyroidism

Drugs for Postsurgical Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Parathyroid hormone Approved, Investigational Not Applicable 9002-64-6
2
Calcium Approved, Nutraceutical Not Applicable 7440-70-2 271
3 Hormones Not Applicable
4 Calcium, Dietary Not Applicable
5 Hormones, Hormone Substitutes, and Hormone Antagonists
6 Hormone Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Levothyroxine Replacement With Liquid Gel Capsules vs Tablets Post-thyroidectomy Recruiting NCT02946918 Phase 4 Levothyroxine
2 Levothyroxine Treatment for Subclinical Hypothyroidism After Head and Neck Surgery Unknown status NCT02548715 Phase 2, Phase 3 Levothyroxine;Placebo
3 EIS in Thyroid and Parathyroid Surgery Completed NCT02901873 Not Applicable
4 Is Levothyroxine Alone Adequate Thyroid Hormone Replacement? Recruiting NCT02567877 levothyroxine in thyroidectomy patients

Search NIH Clinical Center for Postsurgical Hypothyroidism

Genetic Tests for Postsurgical Hypothyroidism

Anatomical Context for Postsurgical Hypothyroidism

MalaCards organs/tissues related to Postsurgical Hypothyroidism:

42
Thyroid

Publications for Postsurgical Hypothyroidism

Articles related to Postsurgical Hypothyroidism:

(show all 12)
# Title Authors Year
1
Clinical Features of Early and Late Postoperative Hypothyroidism After Lobectomy. ( 28324106 )
2017
2
The Effect of Levothyroxine Discontinuation Timing on Postoperative Hypothyroidism after Hemithyroidectomy for Papillary Thyroid Microcarcinoma. ( 27293432 )
2016
3
Early Cardiac Tamponade in a Patient with Postsurgical Hypothyroidism. ( 26294982 )
2015
4
Factors associated with postoperative hypothyroidism after lobectomy in papillary thyroid microcarcinoma patients. ( 25111668 )
2015
5
Thyroid function after unilateral total lobectomy: risk factors for postoperative hypothyroidism. ( 18936354 )
2008
6
NIS mRNA expression level in resected thyroid tissue as a marker of postoperative hypothyroidism after subtotal thyroidectomy in patients with Graves' disease. ( 18187871 )
2008
7
Emergency approach to psychosis in postoperative hypothyroidism. ( 17912160 )
2007
8
[Postoperative hypothyroidism in patients with multi-nodular goiter]. ( 12953431 )
2003
9
Trial of autotransplantation of cryopreserved thyroid tissue for postoperative hypothyroidism in patients with Graves' disease. ( 11800336 )
2002
10
Pathophysiology and predictivity of postoperative hypothyroidism. ( 3225175 )
1988
11
Histometry of lymphoid infiltrate in the thyroid of primary thyrotoxicosis patients. Relation of extent of thyroiditis to preoperative drug treatment and postoperative hypothyroidism. ( 932230 )
1976
12
An unusual case of malignant exophthalmos and postoperative hypothyroidism complicating Graves' disease. ( 13084736 )
1953

Variations for Postsurgical Hypothyroidism

Expression for Postsurgical Hypothyroidism

Search GEO for disease gene expression data for Postsurgical Hypothyroidism.

Pathways for Postsurgical Hypothyroidism

Pathways related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.64 HP LPA
2 9.58 TG TRH TSHR

GO Terms for Postsurgical Hypothyroidism

Biological processes related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.67 CSF3 PTH TG TRH
2 cell-cell signaling GO:0007267 9.61 PTH TRH TSHR
3 potassium ion import across plasma membrane GO:1990573 9.46 ATP12A ATP4A
4 ATP hydrolysis coupled proton transport GO:0015991 9.4 ATP12A ATP4A
5 response to ethanol GO:0045471 9.33 CSF3 PTH TRH
6 cellular sodium ion homeostasis GO:0006883 9.32 ATP12A ATP4A
7 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.26 ATP12A ATP4A
8 cellular potassium ion homeostasis GO:0030007 8.96 ATP12A ATP4A
9 sodium ion export across plasma membrane GO:0036376 8.62 ATP12A ATP4A

Molecular functions related to Postsurgical Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.33 PTH TG TRH
2 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Postsurgical Hypothyroidism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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