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PALE
MCID: PST092
MIFTS: 34

Posttransplant Acute Limbic Encephalitis (PALE)

Categories: Neuronal diseases, Rare diseases
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Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Posttransplant Acute Limbic Encephalitis

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MalaCards integrated aliases for Posttransplant Acute Limbic Encephalitis:

Name: Posttransplant Acute Limbic Encephalitis 58
Pale 58

Characteristics:


Age Of Onset:

All ages 58

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32
Orphanet: 58  
Rare neurological diseases


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Summaries for Posttransplant Acute Limbic Encephalitis

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Orphanet: 58 Posttransplant acute limbic encephalitis is a rare, acquired, non-paraneoplastic limbic encephalitis disorder, that develops in the setting of treatment-related immunosuppression, typically after allogeneic hemapoietic stem cell transplantation, characterized by onset of confusion, headache, anterograde amnesia, seizures and/or loss of consciousness 2-6 weeks following transplantation. Bilateral, non-enhancing T2 hyperintensities in limbic structures are observed on magnetic resonance imaging. Mild cerebrospinal fluid pleocytosis and syndrome of inappropriate antidiuretic hormone secretion may also be associated.

MalaCards based summary: Posttransplant Acute Limbic Encephalitis, also known as pale, is related to clear cell acanthoma and obesity, early-onset, with adrenal insufficiency and red hair. The drugs Dexlansoprazole and Lansoprazole have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and spinal cord, and related phenotypes are seizure and hyponatremia
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Related Diseases for Posttransplant Acute Limbic Encephalitis

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Diseases related to Posttransplant Acute Limbic Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 306)
# Related Disease Score Top Affiliating Genes
1 clear cell acanthoma 11.2
2 obesity, early-onset, with adrenal insufficiency and red hair 11.1
3 iron-refractory iron deficiency anemia 11.1
4 albinism, ocular, with late-onset sensorineural deafness 11.0
5 anemia, sideroblastic, 1 11.0
6 cardiomyopathy, infantile histiocytoid 11.0
7 paroxysmal nocturnal hemoglobinuria 11.0
8 tietz albinism-deafness syndrome 10.9
9 clouston syndrome 10.9
10 optic atrophy 1 10.9
11 anemia, hypochromic microcytic, with iron overload 1 10.9
12 pyruvate kinase deficiency of red cells 10.9
13 alpha-thalassemia 10.9
14 aortic aneurysm, familial thoracic 1 10.9
15 macular dystrophy with central cone involvement 10.9
16 lepromatous leprosy 10.9
17 congenital dyserythropoietic anemia 10.9
18 atrophic lichen planus 10.9
19 glucosephosphate isomerase deficiency 10.9
20 methylmalonic acidemia with homocystinuria 10.9
21 deficiency anemia 10.8
22 oculocutaneous albinism 10.8
23 iron deficiency anemia 10.8
24 syncope 10.8
25 alagille syndrome 1 10.8
26 aortic aneurysm, familial thoracic 4 10.8
27 hashimoto thyroiditis 10.8
28 renal cell carcinoma, nonpapillary 10.8
29 klippel-trenaunay-weber syndrome 10.8
30 chromosome 5q deletion syndrome 10.8
31 motion sickness 10.8
32 noonan syndrome 1 10.8
33 optic atrophy 3, autosomal dominant 10.8
34 paget disease, extramammary 10.8
35 pheochromocytoma 10.8
36 sturge-weber syndrome 10.8
37 albinism, oculocutaneous, type iii 10.8
38 atransferrinemia 10.8
39 folate malabsorption, hereditary 10.8
40 glutamate formiminotransferase deficiency 10.8
41 ghosal hematodiaphyseal dysplasia 10.8
42 hemolytic uremic syndrome, atypical 1 10.8
43 lecithin:cholesterol acyltransferase deficiency 10.8
44 thiamine-responsive megaloblastic anemia syndrome 10.8
45 myeloma, multiple 10.8
46 intrinsic factor deficiency 10.8
47 phosphoglycerate kinase 1 deficiency 10.8
48 anemia, sideroblastic, and spinocerebellar ataxia 10.8
49 spinocerebellar ataxia, x-linked 2 10.8
50 cyclic vomiting syndrome 10.8

Graphical network of the top 20 diseases related to Posttransplant Acute Limbic Encephalitis:



Diseases related to Posttransplant Acute Limbic Encephalitis
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Symptoms & Phenotypes for Posttransplant Acute Limbic Encephalitis

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Human phenotypes related to Posttransplant Acute Limbic Encephalitis:

58 30 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 seizure 58 30 Frequent (33%) Frequent (79-30%)
 HP:0001250
2 hyponatremia 58 30 Frequent (33%) Frequent (79-30%)
 HP:0002902
3 sepsis 58 30 Frequent (33%) Frequent (79-30%)
 HP:0100806
4 memory impairment 58 30 Frequent (33%) Frequent (79-30%)
 HP:0002354
5 viremia 58 30 Frequent (33%) Frequent (79-30%)
 HP:0020071
6 increased csf protein 58 30 Frequent (33%) Frequent (79-30%)
 HP:0002922
7 csf lymphocytic pleiocytosis 58 30 Frequent (33%) Frequent (79-30%)
 HP:0200149
8 eeg with focal epileptiform discharges 58 30 Frequent (33%) Frequent (79-30%)
 HP:0011185
9 hyperglycorrhachia 58 30 Frequent (33%) Frequent (79-30%)
 HP:0031885
10 csf polymorphonuclear pleocytosis 58 30 Frequent (33%) Frequent (79-30%)
 HP:0012756
11 depression 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0000716
12 ataxia 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0001251
13 myoclonus 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0001336
14 anxiety 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0000739
15 dystonia 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0001332
16 psychosis 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0000709
17 confusion 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0001289
18 abnormal hippocampus morphology 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0025100
19 abnormal autonomic nervous system physiology 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0012332
20 eeg with abnormally slow frequencies 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0011203
21 behavioral abnormality 58 Occasional (29-5%)
22 cognitive impairment 58 Occasional (29-5%)
23 abnormality of movement 58 Occasional (29-5%)
Sources

Drugs & Therapeutics for Posttransplant Acute Limbic Encephalitis

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Drugs for Posttransplant Acute Limbic Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6 9578005
2
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
3
Mometasone furoate Approved, Investigational, Vet_approved Phase 4 83919-23-7 4240 441336
4 Anti-Ulcer Agents Phase 4
5 Antacids Phase 4
6 Proton Pump Inhibitors Phase 4
7 Gastrointestinal Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Relationship Between Gastroesophageal Reflux and Pediatric Rhinitis: Significance of Pale/Blue Colored Turbinate. A Randomized Controlled Trial Unknown status NCT02278081 Phase 4 lansoprazole;placebo

Search NIH Clinical Center for Posttransplant Acute Limbic Encephalitis

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Genetic Tests for Posttransplant Acute Limbic Encephalitis

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Anatomical Context for Posttransplant Acute Limbic Encephalitis

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Organs/tissues related to Posttransplant Acute Limbic Encephalitis:

MalaCards : Bone Marrow, Lymph Node, Spinal Cord, Skeletal Muscle, Skin, Breast, Liver
Sources

Publications for Posttransplant Acute Limbic Encephalitis

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Articles related to Posttransplant Acute Limbic Encephalitis:

(show top 50) (show all 9683)
# Title Authors PMID Year
1
Rapid determination of the approximate content of bastnäsite in ores using cathodoluminescence imaging. 62
36327801 2023
2
Reactive oxygen species-mediated oxidative stress accelerates glycolysis via activation of the CaMKKβ/AMPK pathway in the yak longissimus dorsi postmortem. 62
36468614 2023
3
Exploring the role of protein DJ-1 in quality of pale, soft and exudative (PSE) and red, firm and non-exudative (RFN) pork during post-mortem aging. 62
35964574 2023
4
Age and causes of the Yellow River dissecting the Zoige Basin in the eastern Tibetan Plateau, China. 62
36265626 2023
5
First Report of Colletotrichum siamense causing Anthracnose on Pecan in China. 62
36471465 2022
6
Cerium(III) Niobate Layered Perovskites: Abnormal Optical Absorption Modulations by Tuning of B-Site Composition and Perovskite Layer Charge Control. 62
36459091 2022
7
Melanin synthesis genes BgTH and BgDdc affect body color and cuticle permeability in Blattella germanica. 62
35191584 2022
8
Acinetobacter faecalis Sp. Nov., Isolated from Elephant Faeces. 62
36460940 2022
9
Autologous Fat Grafting - A Step Forward in Wound Management. 62
35018850 2022
10
A highly active esterase from Lactobacillus helveticus hydrolyzes chlorogenic acid in sunflower meal to prevent chlorogenic acid induced greening in sunflower protein isolates. 62
36461298 2022
11
Effects of serum aspartate aminotransferase activity on levels of serum Ca2+, Ca2+ channel genes, apoptotic factors, and meat quality characteristics of chicken pectoralis major muscle. 62
36306562 2022
12
Functional unit of supergene in female-limited Batesian mimicry of Papilio polytes. 62
36454671 2022
13
Loss of the placental iron exporter ferroportin 1 causes embryonic demise in late-gestation mouse pregnancy. 62
36398730 2022
14
Andean crops: kañiwa and tarwi flours used for the development of vegan gluten-free muffins. 62
35753031 2022
15
Experimental data-sets on the histopathological and immunohistological assessment of the Interrenal gland (adrenal homolog) of Japanese medaka (Oryzias latipes) fish exposed to graphene oxide. 62
36426008 2022
16
New reports, new species, and high diversity of Cantharellus in the southern Appalachians. 62
36469755 2022
17
Permanent damage of the inner retinal layers in a patient with migraine: a different case of paracentral acute middle maculopathy. 62
36309339 2022
18
Active metabolic lithiasis: A condition that requires proper evaluation and monitoring. 62
36349061 2022
19
A rare combination of methemoglobinemia and carboxyhemoglobinemia in pesticide poisoning. 62
36163065 2022
20
Tongue and pulse features of 668 asymptomatic patients infected with the severe acute respiratory syndrome coronavirus 2 omicron variant in Shanghai. 62
36378060 2022
21
Morphometric study of percutaneous A1 pulley of thumb release. 62
36470935 2022
22
A comprehensive genotype-phenotype evaluation of eight Chinese probands with Waardenburg syndrome. 62
36329483 2022
23
Endoscopic suspect of subacute occlusive mesenteric ischemia. 62
35545898 2022
24
Severe encephalopathy associated with SARS-CoV-2 Omicron BA.1 variant infection in a neonate. 62
35835638 2022
25
[Clinical Comparative Analysis of Early-Onset Preeclampsia Combined with HELLP Syndrome]. 62
36443048 2022
26
Vaginal repair of cesarean section scar defects: Preoperative hysteroscopic evaluation. 62
35996831 2022
27
Methods applied to the Diagnosis of Cattle Trypanosoma Vivax Infection: An Overview of the Current State of The Art. 62
36366850 2022
28
Hepatic Amyloidosis in a Chronically Entangled Grey Seal (Halichoerus grypus). 62
36244232 2022
29
Proteomics and genomics of a monomorphic epitheliotropic intestinal T-cell lymphoma: An extremely rare case report and short review of literature. 62
36451465 2022
30
Low-grade tracheal adenocarcinoma with ETV6::NTRK3 fusion: unique morphology akin to subsets of sinonasal low-grade non-intestinal-type adenocarcinoma. 62
35670854 2022
31
Diffuse Large B-Cell Lymphoma (DLBCL) in an Aged Raccoon (Procyon lotor). 62
36356088 2022
32
Dimorphic cells: a common feature throughout the low nuclear grade breast neoplasia spectrum. 62
36378325 2022
33
Pot-bellied Vietnamese pig with visceral mast cell tumors and mastocytemia. 62
36336840 2022
34
Histological and molecular analysis of cellular leiomyoma with sclerosis: linked to HMGA2 overexpression. 62
35961656 2022
35
Fruit Wine Obtained from Melon by-Products: Physico-Chemical and Sensory Analysis, and Characterization of Key Aromas by GC-MS. 62
36429211 2022
36
Infantile Pompe disease with intrauterine onset: a case report and literature review. 62
36411466 2022
37
An autopsy case report of adult-onset Krabbe disease: Comparison with an infantile-onset case. 62
36200664 2022
38
First Report of Leaf Sheath Disease, Caused by Microdochium seminicola, on Zizania latifolia in China. 62
36320131 2022
39
Control of Globodera pallida using Sinapis alba or 4-hydroxy benzyl alcohol with the trap crop Solanum sisymbriifolium or the biofumigant Brassica juncea seed meal extract. 62
36320132 2022
40
Loss of chloroplast-localized NAD kinase causes ROS stress in Arabidopsis thaliana. 62
36367584 2022
41
First Report of Nalanthamala psidii causing wilt disease of guava in Guangdong, China. 62
36320135 2022
42
First Report of root rot Caused by Fusarium solani and F. breve on kiwifruit in China. 62
36366830 2022
43
First Report of Leaf Spot on Stephania tetrandra Caused by Albifimbria verrucaria in China. 62
36320140 2022
44
Comparison of gastric reactance with commonly used perfusion markers in a swine hypovolemic shock model. 62
36400981 2022
45
Notes on the Occurrence of Abnormal Thoracic and Abdominal Banding in Culex territans Larvae (Diptera: Culicidae). 62
36000967 2022
46
Control of Globodera pallida Using Brassica juncea Seed Meal Extract and the Trap Crop Solanum sisymbriifolium. 62
36428258 2022
47
Morphological and Molecular Characterization of Myxobolus planilizae n. sp. (Cnidaria; Myxosporea; Myxobolidae) Infecting the Largescale Mullet Planiliza macrolepis (Smith, 1846) Collected From Cochin Backwaters, India. 62
36348180 2022
48
First Report of Green Mold Disease Caused by Penicillium ochrochloron on Medicinal Plant Pseudostellaria heterophylla in China. 62
36346364 2022
49
Mucilaginibacter Phenanthrenivorans sp. nov., a Novel Phenanthrene Degradation Bacterium Isolated from Wetland Soil. 62
36329315 2022
50
Characteristics of pulsed electric field cardiac ablation porcine treatment zones with a focal catheter. 62
36335638 2022
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Variations for Posttransplant Acute Limbic Encephalitis

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Expression for Posttransplant Acute Limbic Encephalitis

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Search GEO for disease gene expression data for Posttransplant Acute Limbic Encephalitis.
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Pathways for Posttransplant Acute Limbic Encephalitis

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GO Terms for Posttransplant Acute Limbic Encephalitis

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Sources for Posttransplant Acute Limbic Encephalitis

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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