POTS
MCID: PST048
MIFTS: 46

Postural Orthostatic Tachycardia Syndrome (POTS)

Categories: Cardiovascular diseases, Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Postural Orthostatic Tachycardia Syndrome

MalaCards integrated aliases for Postural Orthostatic Tachycardia Syndrome:

Name: Postural Orthostatic Tachycardia Syndrome 12 20 53 44 15 70
Familial Orthostatic Tachycardia Due to Norepinephrine Transporter Deficiency 12 20
Postural Tachycardia Syndrome Due to Net Deficiency 12 20
Orthostatic Intolerance Due to Net Deficiency 12 20
Mitral Valve Prolapse Syndrome 12 70
Postural Tachycardia Syndrome 20 53
Neurocirculatory Asthenia 12 70
Irritable Heart 12 70
Postural Orthostatic Tachycardia Syndrome Due to Net Deficiency 20
Chronic Othostatic Intolerance 20
Pots Due to Net Deficiency 20
Orhtostatic Intolerance 12
Soldiers Heart 12
Pots 20

Classifications:



External Ids:

Disease Ontology 12 DOID:0111154
MeSH 44 D054972
ICD10 32 I95.1
UMLS 70 C0026267 C0027821 C1299624 more

Summaries for Postural Orthostatic Tachycardia Syndrome

NINDS : 53 Postural orthostatic tachycardia syndrome (POTS) is one of a group of disorders that have orthostatic intolerance (OI) as their primary symptom. OI describes a condition in which an excessively reduced volume of blood returns to the heart after an individual stands up from a lying down position. The primary symptom of OI is lightheadedness or fainting. In POTS, the lightheadedness or fainting is also accompanied by a rapid increase in heartbeat of more than 30 beats per minute, or a heart rate that exceeds 120 beats per minute, within 10 minutes of rising. The faintness or lightheadedness of POTS are relieved by lying down again. Anyone at any age can develop POTS, but the majority of individuals affected (between 75 and 80 percent) are women between the ages of 15 to 50 years of age. Some women report an increase in episodes of POTS right before their menstrual periods. POTS often begins after a pregnancy, major surgery, trauma, or a viral illness. It may make individuals unable to exercise because the activity brings on fainting spells or dizziness. Doctors aren't sure yet what causes the reduced return of blood to the heart that occurs in OI, or why the heart begins to beat so rapidly in POTS.  Current thinking is that there are a number of mechanisms.  Some individuals have peripheral denervation (neuropathic POTS); some have symptoms that are due to sustained or parosyxmal overactivity of the sympathetic nervous system (hyperadrenergic POTS); and many individuals with POTS have significant deconditioning.

MalaCards based summary : Postural Orthostatic Tachycardia Syndrome, also known as familial orthostatic tachycardia due to norepinephrine transporter deficiency, is related to orthostatic intolerance and mitral valve insufficiency, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Postural Orthostatic Tachycardia Syndrome is SLC44A1 (Solute Carrier Family 44 Member 1), and among its related pathways/superpathways are Elastic fibre formation and G-protein signaling_Rap2B regulation pathway. The drugs Cefuroxime and Cefazolin have been mentioned in the context of this disorder. Affiliated tissues include heart, spinal cord and endothelial.

Disease Ontology : 12 A heart conduction disease characterized by orthostatic intolerance that has material basis in heterozygous mutation in the SLC6A2 gene on chromosome 16q12.2.

GARD : 20 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 443236 Definition A rare, genetic, primary orthostatic disorder characterized by dizziness, palpitations, fatigue, blurred vision and tachycardia following postural change from a supine to an upright position, in the absence of hypotension. A syncope with transient cognitive impairment and dyspnea may also occur. The norepinephrine transporter deficiency leads to abnormal uptake and high plasma concentrations of norepinephrine.

Wikipedia : 73 Postural orthostatic tachycardia syndrome (POTS) is a condition in which a change from lying to standing... more...

Related Diseases for Postural Orthostatic Tachycardia Syndrome

Diseases related to Postural Orthostatic Tachycardia Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 216)
# Related Disease Score Top Affiliating Genes
1 orthostatic intolerance 32.4 SLC6A2 REN FBN2 FBN1
2 mitral valve insufficiency 31.2 REN FBN1
3 hypermobile ehlers-danlos syndrome 30.8 FKBP14 FBN1
4 isolated ectopia lentis 29.3 TBRG1 SAP30L MFAP3 FBN2 FBN1 FAM114A2
5 syncope 11.5
6 autonomic dysfunction 11.4
7 dysautonomia 11.4
8 mitral valve prolapse, familial, x-linked 11.4
9 chronic orthostatic intolerance 11.4
10 fainting 11.4
11 hereditary alpha tryptasemia syndrome 11.3
12 autonomic nervous system disease 11.3
13 neurotic disorder 10.8
14 pure autonomic failure 10.8
15 ehlers-danlos syndrome 10.7
16 chronic fatigue syndrome 10.7
17 dystonia 10.6
18 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.6
19 infective endocarditis 10.5
20 autonomic neuropathy 10.5
21 chronic pain 10.5
22 endocarditis 10.5
23 migraine with or without aura 1 10.4
24 mast cell activation syndrome 10.4
25 headache 10.4
26 marfan syndrome 10.4
27 cardiac conduction defect 10.4
28 ehlers-danlos syndrome, hypermobility type 10.4
29 anxiety 10.4
30 hypermobility syndrome 10.4
31 panic disorder 10.4
32 fibromyalgia 10.4
33 pectus excavatum 10.3
34 cardiac arrest 10.3
35 heart valve disease 10.3
36 graves disease 1 10.3
37 multiple sclerosis 10.3
38 storage pool platelet disease 10.3
39 brugada syndrome 10.3
40 covid-19 10.3
41 lyme disease 10.3
42 constipation 10.3
43 homocystinuria 10.3
44 hypoglycemia 10.3
45 raynaud phenomenon 10.3
46 tremor 10.3
47 neuropathy 10.3
48 aortic aneurysm, familial thoracic 2 10.3 FBN2 FBN1
49 tricuspid valve prolapse 10.2 FBN2 FBN1
50 pulmonary valve insufficiency 10.2 REN FBN1

Comorbidity relations with Postural Orthostatic Tachycardia Syndrome via Phenotypic Disease Network (PDN):


Anxiety Dysthymic Disorder
Esophagitis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome

Graphical network of the top 20 diseases related to Postural Orthostatic Tachycardia Syndrome:



Diseases related to Postural Orthostatic Tachycardia Syndrome

Symptoms & Phenotypes for Postural Orthostatic Tachycardia Syndrome

UMLS symptoms related to Postural Orthostatic Tachycardia Syndrome:


angina pectoris; chest pain; edema

Drugs & Therapeutics for Postural Orthostatic Tachycardia Syndrome

Drugs for Postural Orthostatic Tachycardia Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 173)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
2
Cefazolin Approved Phase 4 25953-19-9 33255 656510
3
Cefdinir Approved Phase 4 91832-40-5 6915944
4
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
5
Sulfamethoxazole Approved Phase 4 723-46-6 5329
6
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
7
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
8
Bisoprolol Approved Phase 4 66722-44-9 2405
9
Tranexamic Acid Approved Phase 4 1197-18-8 5526
10
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
11 Vitamin B9 Phase 4
12 cefuroxime axetil Phase 4
13 Cephalosporins Phase 4
14 Folic Acid Antagonists Phase 4
15 Cytochrome P-450 Enzyme Inhibitors Phase 4
16 Clindamycin phosphate Phase 4
17 Vitamin B Complex Phase 4
18 Clindamycin palmitate Phase 4
19 Antiparasitic Agents Phase 4
20 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
21 Antiprotozoal Agents Phase 4
22 Folate Phase 4
23 Antimalarials Phase 4
24 Sympatholytics Phase 4
25 Adrenergic beta-1 Receptor Antagonists Phase 4
26 Pharmaceutical Solutions Phase 4
27 Antibiotics, Antitubercular Phase 4
28 Anti-Bacterial Agents Phase 4
29 Antifibrinolytic Agents Phase 4
30 Coagulants Phase 4
31 Hemostatics Phase 4
32
Cycloserine Approved Phase 3 68-41-7 401 6234
33
Dopamine Approved Phase 2, Phase 3 62-31-7, 51-61-6 681
34
Carbidopa Approved Phase 2, Phase 3 28860-95-9 34359
35
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
36
Alfacalcidol Approved, Nutraceutical Phase 3 41294-56-8 5282181
37 Plasma Substitutes Phase 3
38 Vitamins Phase 3
39 Hydroxycholecalciferols Phase 3
40 Calciferol Phase 3
41 insulin Phase 2, Phase 3
42 Caseins Phase 2, Phase 3
43 Mitogens Phase 2, Phase 3
44 Insulin, Globin Zinc Phase 2, Phase 3
45 Antimetabolites Phase 3
46 Antitubercular Agents Phase 3
47 Anti-Infective Agents Phase 3
48 Dopamine Agents Phase 2, Phase 3
49 Aromatic Amino Acid Decarboxylase Inhibitors Phase 2, Phase 3
50
Metoprolol Approved, Investigational Phase 2 37350-58-6, 51384-51-1 4171

Interventional clinical trials:

(show top 50) (show all 108)
# Name Status NCT ID Phase Drugs
1 A Multicenter, Randomized, Placebo-Controlled, Double-Blind Study Evaluating the Impact of Prophylactic Oral Antibiotics on Sinonasal Outcomes Following Endoscopic Transsphenoidal Surgery for Pituitary Lesions Unknown status NCT03014687 Phase 4 Placebo;Oral Antibiotics cefdinir or trimethoprim/sulfamethoxazole
2 Comparison of Effect of Propranolol, Bisoprolol, Pyridosgitmine in Postural Orthostatic Tachycardia Syndrome (POTS) and Prognosis After Medical Treatment Completed NCT02171988 Phase 4 Propranolol;Bisoprolol;Propranolol+pyridostigmine;Bisoprolol+pyridostgmine
3 Tranexamic Acid Versus Novel Uterine Cooling Technique in Reducing Blood Loss and Incidence of Postpartum Hemorrhage at Caesarean Section Completed NCT02780245 Phase 4 Tranexamic Acid
4 A Double Blind Randomized Controlled Crossover Study to Systematically Assess the Efficacy and Safety of Intravenous Albumin Infusions in Severe Postural Orthostatic Tachycardia Syndrome Unknown status NCT03365414 Phase 3 Normal Saline 0.9% Infusion Solution Bag
5 Effect of Ivabradine on Patients With Postural Orthostatic Tachycardia Syndrome (a Double-blind Placebo-parallel Group Trial) Completed NCT03182725 Phase 3 Ivabradine;Placebo
6 Role of Vitamin D (Alphacalcidol) Supplement to Reduce Pain and Cartilage Oligomeric Matrix Protein Serum Levels in Geriatric Knee Osteoarthritis Patients: A Randomized, Double-Blind, Placebo-Controlled Study Completed NCT04405960 Phase 3 Alfacalcidol 1 MCG Oral Capsule;Sugar pill
7 Influence of Protein Supplements on Serum Insulin-like Growth Factor-I Levels in Women With Anorexia Nervosa Completed NCT01823822 Phase 2, Phase 3
8 1/2 D-cycloserine Augmentation of CBT for Pediatric OCD Completed NCT01411774 Phase 3 d-cycloserine;Pill placebo
9 Kidney Dopamine Effects on Urinary Sodium Excretion in Postural Tachycardia Syndrome Active, not recruiting NCT00685919 Phase 2, Phase 3 Carbidopa;Placebo
10 The Effect of "Funny" Channel Blocker Ivabradine on Patients With Postural Tachycardia Syndrome. Unknown status NCT01761825 Phase 2 ivabradine
11 Einfluss Selektiver I(f)-Blockade Auf Orthostase-Toleranz Und Sympathikusaktivität Bei Gesunden Unknown status NCT00865917 Phase 2 beta-blocker (Metoprolol);I(f)-blocker (ivabradine);Placebo
12 Nasal Irrigation for Chronic Rhinosinusitis and Fatigue in Patients With Gulf War Illness Completed NCT01700725 Phase 2 Nasal Irrigation - Xylitol
13 D-Cycloserine Augmentation of Therapy for Pediatric Obsessive-Compulsive Disorder Completed NCT00864123 Phase 2 D-cycloserine;Placebo pill
14 Northera Improves Postural Tachycardia Syndrome (POTS) and Postural Recruiting NCT02558972 Phase 2 Northera (Droxidopa);Placebo;Northera (Droxidopa);Placebo
15 A Randomized Crossover Study of Propranolol Versus Ivabradine in Postural Tachycardia Syndrome (POTS) Recruiting NCT04186286 Phase 2 Ivabradine 4-week course;Propranolol 4-week course;Placebo 4-week course
16 IVIG (Gamunex-C) Study of Treatment for Autoimmune Neuropathic Dysautonomia/Postural Tachycardia (POTS) Enrolling by invitation NCT03919773 Phase 1, Phase 2 IVIG;Albumin
17 The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome Enrolling by invitation NCT03674541 Phase 2 Pyridostigmine Bromide;Placebo
18 A Double-Blinded, Placebo-Controlled Study To Assess Hemodynamic Changes, Orthostatic Tolerance, Out-Patient Fatigue And Quality Of Life In Neuropathic And Non-Neuropathic POTS Patients In Response To Adrenoreceptor Agonist And Antagonist Terminated NCT03070730 Phase 1, Phase 2 Droxidopa;Atenolol;Placebos
19 A Randomized, Controlled, Double Blinded Clinical Trial of Intravenous Iron Sucrose in Adolescents With Non-anemic Iron Deficiency and Postural Orthostatic Tachycardia Syndrome (POTS) Terminated NCT01978535 Phase 1, Phase 2 Iron infusion;Normal saline infusion
20 The Renin-Aldosterone Axis in Postural Tachycardia Syndrome Completed NCT00962949 Phase 1 Angiotensin II
21 Autonomic Nervous System and Chronic Fatigue Syndrome Completed NCT00580619 Phase 1 L-NMMA trimethaphan;methyldopa
22 Assessment of Safety of Intravitreal POT-4 Therapy for Patients With Neovascular Age-Related Macular Degeneration (AMD) Completed NCT00473928 Phase 1 POT-4
23 Vagal Stimulation in POTS - The Autonomic Inflammatory Reflex (Pilot 3) Active, not recruiting NCT03124355 Phase 1 placebo sugar pill;Pyridostigmine Pill;Galantamine Pill
24 Reducing Orthostatic Intolerance With Oral Rehydration in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Active, not recruiting NCT02854683 Phase 1 Normal Saline
25 Clinical Efficacy of High-Sodium Diet and External Abdominal Compression in the Treatment of Orthostatic Intolerance in POTS Terminated NCT01771484 Phase 1
26 The European Bifurcation Club Left Main Study: A Randomised Comparison of Single Versus Dual Stent Implantation for Distal Left Main True Coronary Bifurcation Lesions Unknown status NCT02497014
27 The Effects of a Systematic Pain Assessment Approach on Critically Ill Patients Outcomes: A Randomized Interventional Clinical Study Unknown status NCT02435589
28 Origins of Cognitive Dysfunction in Postural Tachycardia Syndrome (POTS) Completed NCT01366963
29 Assessment of Objective Sleep Disturbances in Orthostatic Intolerance Completed NCT00581022
30 Electroencephalographic (EEG) Characteristics of Postural Tachycardia Syndrome (POTS) and Syncope (Without POTS) During Head-upright Tilt Table Testing Completed NCT02167412
31 Gabapentin Treatment of Postural Tachycardia Syndrome (PoTS): a Pilot Study Completed NCT04345432 Gabapentin
32 Qualitative Sweat Distribution Among Youth With Postural Tachycardia Syndrome (POTS), Syncope, or Anxiety Completed NCT02329548
33 Assessment of Vascular Endothelial Function in Postural Tachycardia Syndrome (POTS) Completed NCT01308099
34 POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME AND GASTROINTESTINAL SYMPTOMS: Contribution of Gastrointestinal Peptides Completed NCT03263819
35 Local Vasoconstriction in Postural Tachycardia Syndrome Completed NCT01210430 Early Phase 1 Losartan;Ascorbic Acid (Vitamin C);Normal Saline
36 Renal Salt Handling in Postural Tachycardia Syndrome Following Dietary Dopa Administration Completed NCT01064739 Early Phase 1
37 Abdominal and Lower Extremity Compression During Tilt Table Testing in Adolescent POTS Patients Completed NCT01795469
38 Tilt Table and Autonomic Testing in Suspected POTS Subjects Completed NCT01617616
39 Head Circumference Growth in Children With Ehlers-Danlos Syndrome Who Develop Dysautonomia ("POTS" -- Postural Orthostatic Tachycardia Syndrome)Later in Life -- a Retrospective Analysis Completed NCT01367977
40 Evaluation of the Compensatory Reserve Index and Psychosocial Factors in Pediatric Autonomic Dysfunction Completed NCT03974737
41 Autonomic Profiles in Pediatric Patients With Cyclic Vomiting Syndrome, Irritable Bowel Syndrome, Postural Orthostatic Tachycardia Syndrome, Functional Abdominal Pain or Chronic Nausea Completed NCT00728026
42 Relationship of Autonomic Function to Hypnotic Susceptibility Completed NCT00061009
43 Effects of Exercise in Orthostatic Intolerance Completed NCT00770484 Propranolol then Placebo;Placebo then Propranolol
44 Clinical Autonomic Disorders: A Training Protocol Completed NCT02154009
45 Evaluation of Effects of Fermented Dairy Products Containing Probiotics Alone or in Association With Fibers on Bowel Functions, Constipation Symptoms and Health Related Quality of Life in Adult Subjects With Moderate Constipation: an Exploratory Randomized Double-blind, Controlled Adaptive Study Completed NCT02461485
46 Effect of the Consumption of Yogurt Fortified in Calcium and Vitamin D on the Circulating Levels of 25OHD in Postmenopausal Women Completed NCT02534064
47 Association Between GI Microbiota, Low-grade Inflammation and Classical Pathophysiological Factors in Patients With Irritable Bowel Syndrome (IBS) and Effect of the Consumption of Activia on GI Symptoms Provoked by a Lactulose Challenge Test in IBS Patients Completed NCT01252550
48 Evaluation of a 28-day Fermented Milk Product Consumption Twice Daily as Compared to a Non-fermented Milk Product on Intestinal Gas Production in Healthy Subjects High Dihydrogen Producers A Randomized, Controlled, Double-blind, Parallel Arms, Adaptive Study Completed NCT03015441
49 A Randomized Control Trial of the Lucky Iron Fish to Improve Hemoglobin Concentration in Women in Preah Vihear, Cambodia Completed NCT02341586
50 Exploratory Study Aiming at Assessing the Impact of Specific and Controlled Diets Combined With a Fermented Milk Product on Gas-related Symptoms and Associated Measurements in FGID and Non-FGID Subjects Completed NCT02936713

Search NIH Clinical Center for Postural Orthostatic Tachycardia Syndrome

Cochrane evidence based reviews: postural orthostatic tachycardia syndrome

Genetic Tests for Postural Orthostatic Tachycardia Syndrome

Anatomical Context for Postural Orthostatic Tachycardia Syndrome

MalaCards organs/tissues related to Postural Orthostatic Tachycardia Syndrome:

40
Heart, Spinal Cord, Endothelial, Pituitary, Temporal Lobe, Eye, Retina

Publications for Postural Orthostatic Tachycardia Syndrome

Articles related to Postural Orthostatic Tachycardia Syndrome:

(show top 50) (show all 456)
# Title Authors PMID Year
1
Restless legs syndrome is increased in postural orthostatic tachycardia syndrome. 61
33231164 2021
2
Long-Haul Post-COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrome: The Swedish Experience. 61
33723532 2021
3
Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infection: a case series of 20 patients. 61
33786700 2021
4
Recommendations for tilt table testing and other provocative cardiovascular autonomic tests in conditions that may cause transient loss of consciousness. 61
33752997 2021
5
Further Observations on the Use of Pacemakers in Patients with Postural Orthostatic Tachycardia Syndrome with Demonstrated Asystole. 61
33777484 2021
6
Response to Letter: Postural Orthostatic Tachycardia Syndrome in Children-A Single-Center Study. 61
33661061 2021
7
Recommendations for tilt table testing and other provocative cardiovascular autonomic tests in conditions that may cause transient loss of consciousness : Consensus statement of the European Federation of Autonomic Societies (EFAS) endorsed by the American Autonomic Society (AAS) and the European Academy of Neurology (EAN). 61
33740206 2021
8
Prevalence of joint hypermobility syndromes in pediatric postural orthostatic tachycardia syndrome. 61
33388686 2021
9
Is postural orthostatic tachycardia syndrome (POTS) a central nervous system disorder? 61
33677650 2021
10
Postural orthostatic tachycardia syndrome following open thoracoabdominal aortic aneurysm repair. 61
33623665 2021
11
Postural orthostatic tachycardia syndrome is associated with significant employment and economic loss. 61
33586284 2021
12
Inflammatory Biomarkers in Postural Orthostatic Tachycardia Syndrome with Elevated G-Protein-Coupled Receptor Autoantibodies. 61
33562074 2021
13
Autonomic dysfunction in childhood hypersomnia disorders. 61
33385777 2021
14
Raising the bar in postural orthostatic tachycardia syndrome research: Evidence and challenges. 61
33714702 2021
15
Imaging findings of pelvic venous insufficiency in patients with postural orthostatic tachycardia syndrome. 61
32757696 2021
16
Higher Quality Evidence to Guide Our Management of Postural Orthostatic Tachycardia Syndrome: A New Era? 61
33602469 2021
17
gAChR antibodies in children and adolescents with acquired autoimmune dysautonomia in Japan. 61
33621398 2021
18
Postural orthostatic tachycardia syndrome - an 'invisible condition' with far-reaching consequences. 61
33544934 2021
19
Randomized Trial of Ivabradine in Patients With Hyperadrenergic Postural Orthostatic Tachycardia Syndrome. 61
33602468 2021
20
Supraventricular Tachycardia and Postural Orthostatic Tachycardia Syndrome Overlap: A Retrospective Study. 61
33654569 2021
21
Adalimumab as a potential treatment for postural orthostatic tachycardia syndrome. 61
33505857 2021
22
EMA's mishandling of an investigation into suspected serious neurological harms of HPV vaccines. 61
33514652 2021
23
Postural orthostatic tachycardia syndrome in patients of orthostatic intolerance symptoms: an ambispective study. 61
33490373 2021
24
Prevalence of gastrointestinal, cardiovascular, autonomic, and allergic manifestations in hospitalized patients with Ehlers-Danlos syndrome: a case-control study. 61
33410480 2021
25
Regional Gastrointestinal Transit and Contractility Patterns Vary in Postural Orthostatic Tachycardia Syndrome (POTS). 61
33428036 2021
26
Cardiovascular exercise as a treatment of postural orthostatic tachycardia syndrome: A pragmatic treatment trial. 61
33482385 2021
27
Compression Garment Reduces Orthostatic Tachycardia and Symptoms in Patients With Postural Orthostatic Tachycardia Syndrome. 61
33478652 2021
28
Mechanisms and management of gastrointestinal symptoms in postural orthostatic tachycardia syndrome. 61
33140561 2020
29
Increased Salt Intake for Orthostatic Intolerance Syndromes: A Systematic Review and Meta-Analysis. 61
32603788 2020
30
A Pilot Study using the Compensatory Reserve Index to evaluate individuals with Postural Orthostatic Tachycardia syndrome. 61
32993834 2020
31
Was the diagnosis really postural orthostatic tachycardia syndrome? 61
33191893 2020
32
Comparisons of the Nonlinear Relationship of Cerebral Blood Flow Response and Cerebral Vasomotor Reactivity to Carbon Dioxide under Hyperventilation between Postural Orthostatic Tachycardia Syndrome Patients and Healthy Subjects. 61
33352894 2020
33
Treatment of Postural Orthostatic Tachycardia Syndrome With Medication: A Systematic Review. 61
32838632 2020
34
Dimensional latent factor structure of psychopathology in adults with chronic illness. 61
33271041 2020
35
Cosegregation of postural orthostatic tachycardia syndrome, hypermobile Ehlers-Danlos syndrome, and mast cell activation syndrome. 61
32798618 2020
36
Functional gastrointestinal disorders are increased in joint hypermobility-related disorders with concomitant postural orthostatic tachycardia syndrome. 61
32803794 2020
37
Characterization of Blood Pressure and Heart Rate Oscillations of POTS Patients via Uniform Phase Empirical Mode Decomposition. 61
32078525 2020
38
New-onset Postural Orthostatic Tachycardia Syndrome Following Coronavirus Disease 2019 Infection. 61
33262898 2020
39
Postural Orthostatic Tachycardia Syndrome and Disordered Eating: Clarifying the Overlap. 61
33181565 2020
40
Reductions in Cerebral Blood Flow Can Be Provoked by Sitting in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients. 61
33050553 2020
41
Psychiatric Disorder in Postural Orthostatic Tachycardia Syndrome and Ehlers-Danlos Syndrome-Hypermobility Type. 61
33125200 2020
42
Quantitative sensory testing predicts histological small fiber neuropathy in postural tachycardia syndrome. 61
33299671 2020
43
Work Ability Assessment and Its Relationship with Cardiovascular Autonomic Profile in Postural Orthostatic Tachycardia Syndrome. 61
33114659 2020
44
The incidence of postural orthostatic tachycardia syndrome in the population of Zagreb, Croatia. 61
33150760 2020
45
Postural Orthostatic Tachycardia Syndrome Misdiagnosed as Anxiety: A Case Report with a Review of Therapy and Pathophysiology. 61
33178533 2020
46
Pediatric Syncope: A Systematic Review. 61
32530839 2020
47
Association between quadrivalent human papillomavirus vaccination and selected syndromes with autonomic dysfunction in Danish females: population based, self-controlled, case series analysis. 61
32878745 2020
48
Psychological correlates of patients with postural orthostatic tachycardia syndrome (POTS). 61
32544859 2020
49
Bier anemic spots, cyanosis, and urticaria-like eruption (BASCULE) syndrome: Report of two new cases and literature review. 61
32648305 2020
50
Time Course of Autonomic Symptoms in Postural Orthostatic Tachycardia Syndrome (POTS) Patients: Two-Year Follow-Up Results. 61
32823577 2020

Variations for Postural Orthostatic Tachycardia Syndrome

Expression for Postural Orthostatic Tachycardia Syndrome

Search GEO for disease gene expression data for Postural Orthostatic Tachycardia Syndrome.

Pathways for Postural Orthostatic Tachycardia Syndrome

Pathways related to Postural Orthostatic Tachycardia Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.66 MFAP3 FBN2 FBN1
2 10.36 FBN1 FBN2 GNAT1 TBRG1
3 10.35 FBN1 FBN2

GO Terms for Postural Orthostatic Tachycardia Syndrome

Cellular components related to Postural Orthostatic Tachycardia Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microfibril GO:0001527 8.62 FBN2 FBN1

Biological processes related to Postural Orthostatic Tachycardia Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 embryonic eye morphogenesis GO:0048048 8.96 FBN2 FBN1
2 sequestering of TGFbeta in extracellular matrix GO:0035583 8.62 FBN2 FBN1

Molecular functions related to Postural Orthostatic Tachycardia Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix constituent conferring elasticity GO:0030023 8.62 FBN2 FBN1

Sources for Postural Orthostatic Tachycardia Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....