POTS
MCID: PST048
MIFTS: 45

Postural Orthostatic Tachycardia Syndrome (POTS)

Categories: Cardiovascular diseases, Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Postural Orthostatic Tachycardia Syndrome

MalaCards integrated aliases for Postural Orthostatic Tachycardia Syndrome:

Name: Postural Orthostatic Tachycardia Syndrome 12 52 53 43 15 71
Familial Orthostatic Tachycardia Due to Norepinephrine Transporter Deficiency 12 52
Postural Tachycardia Syndrome Due to Net Deficiency 12 52
Orthostatic Intolerance Due to Net Deficiency 12 52
Mitral Valve Prolapse Syndrome 12 71
Postural Tachycardia Syndrome 52 53
Neurocirculatory Asthenia 12 71
Irritable Heart 12 71
Postural Orthostatic Tachycardia Syndrome Due to Net Deficiency 52
Chronic Othostatic Intolerance 52
Pots Due to Net Deficiency 52
Orhtostatic Intolerance 12
Soldiers Heart 12
Pots 52

Classifications:



External Ids:

Disease Ontology 12 DOID:0111154
MeSH 43 D054972
ICD10 32 I95.1
UMLS 71 C0026267 C0027821 C1299624 more

Summaries for Postural Orthostatic Tachycardia Syndrome

NINDS : 53 Postural orthostatic tachycardia syndrome (POTS) is one of a group of disorders that have orthostatic intolerance (OI) as their primary symptom. OI describes a condition in which an excessively reduced volume of blood returns to the heart after an individual stands up from a lying down position. The primary symptom of OI is lightheadedness or fainting. In POTS, the lightheadedness or fainting is also accompanied by a rapid increase in heartbeat of more than 30 beats per minute, or a heart rate that exceeds 120 beats per minute, within 10 minutes of rising. The faintness or lightheadedness of POTS are relieved by lying down again. Anyone at any age can develop POTS, but the majority of individuals affected (between 75 and 80 percent) are women between the ages of 15 to 50 years of age. Some women report an increase in episodes of POTS right before their menstrual periods. POTS often begins after a pregnancy, major surgery, trauma, or a viral illness. It may make individuals unable to exercise because the activity brings on fainting spells or dizziness. Doctors aren't sure yet what causes the reduced return of blood to the heart that occurs in OI, or why the heart begins to beat so rapidly in POTS.  Current thinking is that there are a number of mechanisms.  Some individuals have peripheral denervation (neuropathic POTS); some have symptoms that are due to sustained or parosyxmal overactivity of the sympathetic nervous system (hyperadrenergic POTS); and many individuals with POTS have significant deconditioning.

MalaCards based summary : Postural Orthostatic Tachycardia Syndrome, also known as familial orthostatic tachycardia due to norepinephrine transporter deficiency, is related to orthostatic intolerance and mitral valve insufficiency, and has symptoms including edema, chest pain and angina pectoris. An important gene associated with Postural Orthostatic Tachycardia Syndrome is SLC44A1 (Solute Carrier Family 44 Member 1), and among its related pathways/superpathways are Elastic fibre formation and Hypothesized Pathways in Pathogenesis of Cardiovascular Disease. The drugs Bisoprolol and Cycloserine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain.

Disease Ontology : 12 A heart conduction disease characterized by orthostatic intolerance that has material basis in heterozygous mutation in the SLC6A2 gene on chromosome 16q12.2.

NIH Rare Diseases : 52 The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 443236 Definition A rare, genetic, primary orthostatic disorder characterized by dizziness, palpitations, fatigue, blurred vision and tachycardia following postural change from a supine to an upright position, in the absence of hypotension. A syncope with transient cognitive impairment and dyspnea may also occur. The norepinephrine transporter deficiency leads to abnormal uptake and high plasma concentrations of norepinephrine. Visit the Orphanet disease page for more resources.

Wikipedia : 74 Postural orthostatic tachycardia syndrome (POTS) is a condition in which a change from lying to standing... more...

Related Diseases for Postural Orthostatic Tachycardia Syndrome

Diseases related to Postural Orthostatic Tachycardia Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)
# Related Disease Score Top Affiliating Genes
1 orthostatic intolerance 33.0 SLC6A2 REN FBN2 FBN1
2 mitral valve insufficiency 31.3 REN FBN1
3 isolated ectopia lentis 29.5 SAP30L MFAP3 FBN2 FBN1 FAM114A2
4 syncope 11.9
5 mitral valve prolapse, familial, x-linked 11.9
6 autonomic dysfunction 11.9
7 dysautonomia 11.9
8 chronic orthostatic intolerance 11.8
9 fainting 11.8
10 autonomic nervous system disease 11.5
11 hereditary alpha tryptasemia syndrome 11.5
12 neurotic disorder 10.9
13 dystonia 10.7
14 pure autonomic failure 10.7
15 chronic fatigue syndrome 10.7
16 ehlers-danlos syndrome 10.6
17 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.6
18 hypermobile ehlers-danlos syndrome 10.6
19 endocarditis 10.5
20 autonomic neuropathy 10.5
21 infective endocarditis 10.5
22 graves disease 1 10.4
23 chronic pain 10.4
24 marfan syndrome 10.4
25 migraine with or without aura 1 10.4
26 hypermobility syndrome 10.4
27 cardiac conduction defect 10.3
28 cardiac arrest 10.3
29 osteochondrosis 10.3
30 aortic aneurysm, familial thoracic 2 10.3 FBN2 FBN1
31 tricuspid valve prolapse 10.3 FBN2 FBN1
32 marden-walker syndrome 10.3 FBN2 FBN1
33 pectus excavatum 10.3
34 heart valve disease 10.3
35 congestive heart failure 10.3
36 acromicric dysplasia 10.3 FBN2 FBN1
37 autoimmune disease 10.3
38 multiple sclerosis 10.3
39 ehlers-danlos syndrome, hypermobility type 10.3
40 brugada syndrome 10.3
41 lyme disease 10.3
42 constipation 10.3
43 panic disorder 10.3
44 fibromyalgia 10.3
45 homocystinuria 10.3
46 hypoglycemia 10.3
47 mast cell activation syndrome 10.3
48 raynaud phenomenon 10.3
49 headache 10.3
50 tremor 10.3

Comorbidity relations with Postural Orthostatic Tachycardia Syndrome via Phenotypic Disease Network (PDN):


Anxiety Dysthymic Disorder
Esophagitis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome

Graphical network of the top 20 diseases related to Postural Orthostatic Tachycardia Syndrome:



Diseases related to Postural Orthostatic Tachycardia Syndrome

Symptoms & Phenotypes for Postural Orthostatic Tachycardia Syndrome

UMLS symptoms related to Postural Orthostatic Tachycardia Syndrome:


edema, chest pain, angina pectoris

Drugs & Therapeutics for Postural Orthostatic Tachycardia Syndrome

Drugs for Postural Orthostatic Tachycardia Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 188)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bisoprolol Approved Phase 4 66722-44-9 2405
2
Cycloserine Approved Phase 3 68-41-7 401 6234
3
Dopamine Approved Phase 2, Phase 3 51-61-6, 62-31-7 681
4
Carbidopa Approved Phase 2, Phase 3 28860-95-9 34359
5
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
6
Alfacalcidol Approved, Nutraceutical Phase 3 41294-56-8 5282181
7 Trace Elements Phase 3
8 Micronutrients Phase 3
9 Vitamins Phase 3
10 Nutrients Phase 3
11 Calciferol Phase 3
12 Antimetabolites Phase 3
13 Caseins Phase 2, Phase 3
14 Insulin, Globin Zinc Phase 2, Phase 3
15 Mitogens Phase 2, Phase 3
16 insulin Phase 2, Phase 3
17 Antitubercular Agents Phase 3
18 Antibiotics, Antitubercular Phase 3
19 Hydroxycholecalciferols Phase 3
20 Aromatic Amino Acid Decarboxylase Inhibitors Phase 2, Phase 3
21 Dopamine Agents Phase 2, Phase 3
22 Pharmaceutical Solutions Phase 3
23 Plasma Substitutes Phase 3
24 Acidophilus Phase 2, Phase 3
25
Metoprolol Approved, Investigational Phase 2 37350-58-6, 51384-51-1 4171
26
Modafinil Approved, Investigational Phase 1, Phase 2 68693-11-8 4236
27
Nitric Oxide Approved Phase 1, Phase 2 10102-43-9 145068
28
Midodrine Approved Phase 1, Phase 2 133163-28-7, 42794-76-3 4195
29
Acetazolamide Approved, Vet_approved Phase 1, Phase 2 59-66-5 1986
30
Entacapone Approved, Investigational Phase 1, Phase 2 130929-57-6 5281081
31
Octreotide Approved, Investigational Phase 1, Phase 2 83150-76-9 383414 6400441
32
Isosorbide Dinitrate Approved, Investigational Phase 1, Phase 2 87-33-2 6883
33
Clonidine Approved Phase 1, Phase 2 4205-90-7 2803
34
Mecamylamine Approved, Investigational Phase 1, Phase 2 60-40-2 4032
35
AT-101 Approved, Investigational Phase 1, Phase 2 652-67-5, 90141-22-3 12597
36
Indomethacin Approved, Investigational Phase 1, Phase 2 53-86-1 3715
37
Sertraline Approved Phase 1, Phase 2 79617-96-2 68617
38
Memantine Approved, Investigational Phase 1, Phase 2 19982-08-2 4054
39
Propranolol Approved, Investigational Phase 2 525-66-6 4946
40
Albendazole Approved, Vet_approved Phase 2 54965-21-8 2082
41
Ivermectin Approved, Investigational, Vet_approved Phase 2 70288-86-7 6474909
42
Droxidopa Approved, Investigational Phase 1, Phase 2 23651-95-8 443940
43
Atenolol Approved Phase 1, Phase 2 29122-68-7 2249
44
Iron Approved, Experimental Phase 1, Phase 2 15438-31-0, 7439-89-6 27284 23925
45
Melatonin Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 73-31-4 896
46 Vasoconstrictor Agents Phase 1, Phase 2
47 Cholinergic Agents Phase 1, Phase 2
48 Protective Agents Phase 1, Phase 2
49 Catechol Phase 1, Phase 2
50 Adrenergic alpha-Agonists Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 111)
# Name Status NCT ID Phase Drugs
1 Comparison of Effect of Propranolol, Bisoprolol, Pyridosgitmine in Postural Orthostatic Tachycardia Syndrome (POTS) and Prognosis After Medical Treatment Completed NCT02171988 Phase 4 Propranolol;Bisoprolol;Propranolol+pyridostigmine;Bisoprolol+pyridostgmine
2 Influence of Protein Supplements on Serum Insulin-like Growth Factor-I Levels in Women With Anorexia Nervosa Completed NCT01823822 Phase 2, Phase 3
3 Role of Vitamin D (Alphacalcidol) Supplement to Reduce Pain and Cartilage Oligomeric Matrix Protein Serum Levels in Geriatric Knee Osteoarthritis Patients: A Randomized, Double-Blind, Placebo-Controlled Study Completed NCT04405960 Phase 3 Alfacalcidol 1 MCG Oral Capsule;Sugar pill
4 1/2 D-cycloserine Augmentation of CBT for Pediatric OCD Completed NCT01411774 Phase 3 d-cycloserine;Pill placebo
5 Effect of Ivabradine on Patients With Postural Orthostatic Tachycardia Syndrome (a Double-blind Placebo-parallel Group Trial) Active, not recruiting NCT03182725 Phase 3 Ivabradine;Placebo
6 Kidney Dopamine Effects on Urinary Sodium Excretion in Postural Tachycardia Syndrome Active, not recruiting NCT00685919 Phase 2, Phase 3 Carbidopa;Placebo
7 A Double Blind Randomized Controlled Crossover Study to Systematically Assess the Efficacy and Safety of Intravenous Albumin Infusions in Severe Postural Orthostatic Tachycardia Syndrome Not yet recruiting NCT03365414 Phase 3 Normal Saline 0.9% Infusion Solution Bag
8 Daily Intake of Lactobacillus Casei Shirota (LcS) Modulates Intestinal Permeability and Decreases Circulating Levels of Endotoxin That Associate With Both Cardiovascular and All-cause Mortality in Haemodialysis Patients Not yet recruiting NCT04390347 Phase 2, Phase 3
9 The Effect of "Funny" Channel Blocker Ivabradine on Patients With Postural Tachycardia Syndrome. Unknown status NCT01761825 Phase 2 ivabradine
10 Einfluss Selektiver I(f)-Blockade Auf Orthostase-Toleranz Und Sympathikusaktivität Bei Gesunden Unknown status NCT00865917 Phase 2 beta-blocker (Metoprolol);I(f)-blocker (ivabradine);Placebo
11 D-Cycloserine Augmentation of Therapy for Pediatric Obsessive-Compulsive Disorder Completed NCT00864123 Phase 2 D-cycloserine;Placebo pill
12 Northera Improves Postural Tachycardia Syndrome (POTS) and Postural Recruiting NCT02558972 Phase 2 Northera (Droxidopa);Placebo;Northera (Droxidopa);Placebo
13 Treatment of Orthostatic Intolerance Active, not recruiting NCT00262470 Phase 1, Phase 2 Acetazolamide;Atomoxetine;Clonidine;Entacapone;Entacapone & Propranolol;Atomoxetine & Propranolol;Indomethacin;Mecamylamine;Isosorbide Dinitrate;Midodrine;Modafinil;Octreotide;Propranolol;Modafinil & Propranolol;Sertraline;memantine
14 IVIG (Gamunex-C) Study of Treatment for Autoimmune Neuropathic Dysautonomia/Postural Tachycardia (POTS) Enrolling by invitation NCT03919773 Phase 1, Phase 2 IVIG;Albumin
15 A Randomized Crossover Study of Propranolol Versus Ivabradine in Postural Tachycardia Syndrome (POTS) Not yet recruiting NCT04186286 Phase 2 Ivabradine 4-week course;Propranolol 4-week course;Placebo 4-week course
16 Prospective, Parallel-group, Open-label Randomized Controlled Trial of Four Treatment Regimes for Trichuriasis in Pediatric Patients Not yet recruiting NCT04041453 Phase 2 Ivermectin;Albendazole
17 A Double-Blinded, Placebo-Controlled Study To Assess Hemodynamic Changes, Orthostatic Tolerance, Out-Patient Fatigue And Quality Of Life In Neuropathic And Non-Neuropathic POTS Patients In Response To Adrenoreceptor Agonist And Antagonist Terminated NCT03070730 Phase 1, Phase 2 Droxidopa;Atenolol;Placebos
18 A Randomized, Controlled, Double Blinded Clinical Trial of Intravenous Iron Sucrose in Adolescents With Non-anemic Iron Deficiency and Postural Orthostatic Tachycardia Syndrome (POTS) Terminated NCT01978535 Phase 1, Phase 2 Iron infusion;Normal saline infusion
19 The Renin-Aldosterone Axis in Postural Tachycardia Syndrome Completed NCT00962949 Phase 1 Angiotensin II
20 Autonomic Nervous System and Chronic Fatigue Syndrome Completed NCT00580619 Phase 1 L-NMMA trimethaphan;methyldopa
21 The Effect of Antioxidants on Skin Blood Flow During Local Heating Completed NCT03680638 Phase 1 Tempol;Apocynin;Allopurinol
22 Prospective Single-Arm Pilot Study for CT-Guided, Temporary Celiac Ganglion Block as a Test Before Celiac Ganglion Resection for Dysautonomia-Related Bowel Dysmotility Recruiting NCT04121338 Phase 1 Liposomal bupivacaine
23 Vagal Stimulation in POTS - The Autonomic Inflammatory Reflex (Pilot 3) Active, not recruiting NCT03124355 Phase 1 placebo sugar pill;Pyridostigmine Pill;Galantamine Pill
24 Reducing Orthostatic Intolerance With Oral Rehydration in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Active, not recruiting NCT02854683 Phase 1 Normal Saline
25 Clinical Efficacy of High-Sodium Diet and External Abdominal Compression in the Treatment of Orthostatic Intolerance in POTS Terminated NCT01771484 Phase 1
26 Evaluation of Sleep Disordered Breathing and Autonomic Dysfunction in Fibromyalgia Through Peripheral Arterial Tonometry Unknown status NCT01151163
27 Prevalence and Mechanism of Palpitations and Tachycardia in Fibromyalgia Syndrome Unknown status NCT01147263
28 Does Screening Parents Allow Targeting of a Paediatric Intensive Care Follow-up Clinic? A Feasibility Study Unknown status NCT01628263
29 Does Mechanical Bowel Preparation Destabilise the Gut Microbiota and Provide a Window of Opportunity in Which to Influence the Re-establishing Microbiota in Diverticulosis? Unknown status NCT03465293
30 Assessment of Vascular Endothelial Function in Postural Tachycardia Syndrome (POTS) Completed NCT01308099
31 Assessment of Objective Sleep Disturbances in Orthostatic Intolerance Completed NCT00581022
32 Origins of Cognitive Dysfunction in Postural Tachycardia Syndrome (POTS) Completed NCT01366963
33 Gabapentin Treatment of Postural Tachycardia Syndrome (PoTS): a Pilot Study Completed NCT04345432 Gabapentin
34 Local Vasoconstriction in Postural Tachycardia Syndrome Completed NCT01210430 Early Phase 1 Losartan;Ascorbic Acid (Vitamin C);Normal Saline
35 Qualitative Sweat Distribution Among Youth With Postural Tachycardia Syndrome (POTS), Syncope, or Anxiety Completed NCT02329548
36 Effects of Exercise in Orthostatic Intolerance Completed NCT00770484 Propranolol then Placebo;Placebo then Propranolol
37 Abdominal and Lower Extremity Compression During Tilt Table Testing in Adolescent POTS Patients Completed NCT01795469
38 Renal Salt Handling in Postural Tachycardia Syndrome Following Dietary Dopa Administration Completed NCT01064739 Early Phase 1
39 Electroencephalographic (EEG) Characteristics of Postural Tachycardia Syndrome (POTS) and Syncope (Without POTS) During Head-upright Tilt Table Testing Completed NCT02167412
40 Relationship of Autonomic Function to Hypnotic Susceptibility Completed NCT00061009
41 Head Circumference Growth in Children With Ehlers-Danlos Syndrome Who Develop Dysautonomia ("POTS" -- Postural Orthostatic Tachycardia Syndrome)Later in Life -- a Retrospective Analysis Completed NCT01367977
42 Implementation of a Transdiagnostic Psychological Group Intervention for Pediatric Autonomic Dysfunction Completed NCT03185247
43 Study Title: Brain Transmitters/Metabolites, Magnetic Resonance Spectroscopy, and Brain Connectivity: Diagnostic Strategies to Study the Effects of Non-Pharmacologic Therapies for Dysautonomia and Chronic Nausea Completed NCT01692561
44 Autonomic Profiles in Pediatric Patients With Cyclic Vomiting Syndrome, Irritable Bowel Syndrome, Postural Orthostatic Tachycardia Syndrome, Functional Abdominal Pain or Chronic Nausea Completed NCT00728026
45 Tilt Table and Autonomic Testing in Suspected POTS Subjects Completed NCT01617616
46 START & STOPP in GWI Stress Test Activated Reversible Tachycardia & Stress Test Originated Phantom Perception in Gulf War Illness Completed NCT03560830
47 The PRINCE Secondary Study: Persistent Physical Symptoms Reduction Intervention: a System Change and Evaluation in Secondary Care Completed NCT02426788
48 Clinical Autonomic Disorders: A Training Protocol Completed NCT02154009
49 Clinical Laboratory Evaluation of Chronic Orthostatic Intolerance Completed NCT00069693
50 Evaluation of Effects of Fermented Dairy Products Containing Probiotics Alone or in Association With Fibers on Bowel Functions, Constipation Symptoms and Health Related Quality of Life in Adult Subjects With Moderate Constipation: an Exploratory Randomized Double-blind, Controlled Adaptive Study Completed NCT02461485

Search NIH Clinical Center for Postural Orthostatic Tachycardia Syndrome

Cochrane evidence based reviews: postural orthostatic tachycardia syndrome

Genetic Tests for Postural Orthostatic Tachycardia Syndrome

Anatomical Context for Postural Orthostatic Tachycardia Syndrome

MalaCards organs/tissues related to Postural Orthostatic Tachycardia Syndrome:

40
Heart, Testes, Brain, Spinal Cord, Skin, Kidney, Endothelial

Publications for Postural Orthostatic Tachycardia Syndrome

Articles related to Postural Orthostatic Tachycardia Syndrome:

(show top 50) (show all 397)
# Title Authors PMID Year
1
Pediatric-Onset Postural Orthostatic Tachycardia Syndrome in a Single Tertiary Care Center. 61
32314650 2020
2
Psychological correlates of patients with postural orthostatic tachycardia syndrome (POTS). 61
32544859 2020
3
Ivabradine in children with postural orthostatic tachycardia syndrome: a retrospective study. 61
32498748 2020
4
The Relationship Between Hypermobile Ehlers-Danlos Syndrome (hEDS), Postural Orthostatic Tachycardia Syndrome (POTS), and Mast Cell Activation Syndrome (MCAS). 61
31267471 2020
5
Gastrointestinal motility evaluation in children with orthostatic intolerance: Mayo Clinic experience. 61
32483845 2020
6
Pediatric Syncope: A Systematic Review. 61
32530839 2020
7
[Vasovagal syncope or postural orthostatic tachycardia syndrome in children with neurological symptoms at disease onset: a clinical analysis of 88 cases]. 61
32434646 2020
8
Complex syndromes of chronic pain, fatigue and cognitive impairment linked to autoimmune dysautonomia and small fiber neuropathy. 61
32171889 2020
9
A new insight on postural tachycardia syndrome in 102 adults with hypermobile Ehlers-Danlos Syndrome/hypermobility spectrum disorder. 61
32434316 2020
10
High Submaximal Exercise Heart Rate Impacts Exercise Intolerance in the Postural Orthostatic Tachycardia Syndrome. 61
31972631 2020
11
Effect of a neck compression collar on cardiorespiratory and cerebrovascular function in postural orthostatic tachycardia syndrome (POTS). 61
32163327 2020
12
Proteomic analysis reveals sex-specific biomarker signature in postural orthostatic tachycardia syndrome. 61
32321428 2020
13
Ivabradine in Postural Orthostatic Tachycardia Syndrome: A Review of the Literature. 61
32489723 2020
14
Prevalence and Predictors of Gastrointestinal Dysmotility in Patients with Hypermobile Ehlers-Danlos Syndrome: A Tertiary Care Center Experience. 61
32489735 2020
15
Hospital Records of Pain, Fatigue, or Circulatory Symptoms in Girls Exposed to Human Papillomavirus Vaccination: Cohort, Self-Controlled Case Series, and Population Time Trend Studies. 61
31899791 2020
16
Syncope and hypermobile joints: Not rare, but rarely diagnosed. 61
32147649 2020
17
Canadian Cardiovascular Society Position Statement on Postural Orthostatic Tachycardia Syndrome (POTS) and Related Disorders of Chronic Orthostatic Intolerance. 61
32145864 2020
18
Functional Gastrointestinal Disorders, Autonomic Nervous System Dysfunction, and Joint Hypermobility in Children: Are They Related? 61
31955876 2020
19
Postural Orthostatic Tachycardia Syndrome (POTS): A critical assessment. 61
32222376 2020
20
Prevalence of hypermobile Ehlers-Danlos syndrome in postural orthostatic tachycardia syndrome. 61
31954224 2020
21
Postural Orthostatic Tachycardia Syndrome. 61
32148459 2020
22
Orthostatic heart rate does not predict symptomatic burden in pediatric patients with chronic orthostatic intolerance. 61
31385108 2020
23
Characterization of Blood Pressure and Heart Rate Oscillations in POTS Patients via Uniform Phase Empirical Mode Decomposition. 61
32078525 2020
24
Diagnostic and prognostic value of T-wave amplitude difference between supine and orthostatic electrocardiogram in children and adolescents with postural orthostatic tachycardia syndrome. 61
32112609 2020
25
Exercise alters cerebellar and cortical activity related to working memory in phenotypes of Gulf War Illness. 61
32025659 2020
26
Persistent instability in a nonhomogeneous delay differential equation system of the Valsalva maneuver. 61
31785229 2020
27
Infectious mononucleosis complicated by peritonsillar abscess and postural orthostatic tachycardia syndrome: A case report. 61
32284866 2020
28
Cerebral blood flow is reduced in ME/CFS during head-up tilt testing even in the absence of hypotension or tachycardia: A quantitative, controlled study using Doppler echography. 61
32140630 2020
29
Breathlessness and dysfunctional breathing in patients with postural orthostatic tachycardia syndrome (POTS): The impact of a physiotherapy intervention. 61
31743851 2020
30
Postural Orthostatic Tachycardia Syndrome: Mechanisms and New Therapies. 61
31412221 2020
31
Acute onset and severe manifestation of postural orthostatic tachycardia syndrome - Two cases. 61
31778914 2020
32
Yield and cost-effectiveness of tilt table tests combined with video-EEG. 61
31843734 2019
33
Heart rate and heart rate variability comparison between postural orthostatic tachycardia syndrome versus healthy participants; a systematic review and meta-analysis. 61
31888497 2019
34
Median Arcuate Ligament Syndrome and Its Associated Conditions. 61
31657316 2019
35
Unmasking the true face of postural orthostatic tachycardia syndrome. 61
30968485 2019
36
Monitoring of cerebral oximetry in patients with postural orthostatic tachycardia syndrome. 61
31384930 2019
37
Hop to It: The First Animal Model of Autoimmune Postural Orthostatic Tachycardia Syndrome. 61
31547756 2019
38
Dysautonomia and Headache in the Pediatric Population. 61
31549738 2019
39
Postural orthostatic tachycardia syndrome in primary care: diagnosis, treatment and a case of African-American man presenting with POTS. 61
31537586 2019
40
Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G-Protein Coupled Receptor Autoantibodies. 61
31495251 2019
41
Anaesthetic management of postural orthostatic tachycardia syndrome presenting during pregnancy. 61
30837098 2019
42
Vestibular neurons with direct projections to the solitary nucleus in the rat. 61
31166818 2019
43
A practical guide to active stand testing and analysis using continuous beat-to-beat non-invasive blood pressure monitoring. 61
31076939 2019
44
Sinus Node Sparing Novel Hybrid Approach for Treatment of Inappropriate Sinus Tachycardia/Postural Orthostatic Sinus Tachycardia With New Electrophysiological Finding. 61
31084999 2019
45
Associations of fitness and physical activity with orthostatic responses of heart rate and blood pressure at midlife. 61
30697819 2019
46
Neurocognitive Difficulties Among Youth with POTS within an Intensive Pain Rehabilitation Program. 61
30649432 2019
47
Orthostatic intolerance in chronic fatigue syndrome. 61
31159884 2019
48
Postural Orthostatic Tachycardia Syndrome and Vasospastic Angina: Therapeutic Approach to a Previously Unreported Association. 61
30322723 2019
49
A cluster analysis of serious adverse event reports after human papillomavirus (HPV) vaccination in Danish girls and young women, September 2009 to August 2017. 61
31088598 2019
50
Human leukocyte antigen associations in postural tachycardia syndrome. 61
31139694 2019

Variations for Postural Orthostatic Tachycardia Syndrome

Expression for Postural Orthostatic Tachycardia Syndrome

Search GEO for disease gene expression data for Postural Orthostatic Tachycardia Syndrome.

Pathways for Postural Orthostatic Tachycardia Syndrome

Pathways related to Postural Orthostatic Tachycardia Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.66 MFAP3 FBN2 FBN1
2 10.35 FBN2 FBN1

GO Terms for Postural Orthostatic Tachycardia Syndrome

Cellular components related to Postural Orthostatic Tachycardia Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microfibril GO:0001527 8.62 FBN2 FBN1

Biological processes related to Postural Orthostatic Tachycardia Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 embryonic eye morphogenesis GO:0048048 8.96 FBN2 FBN1
2 sequestering of TGFbeta in extracellular matrix GO:0035583 8.62 FBN2 FBN1

Molecular functions related to Postural Orthostatic Tachycardia Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix constituent conferring elasticity GO:0030023 8.62 FBN2 FBN1

Sources for Postural Orthostatic Tachycardia Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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