MCID: PCH007
MIFTS: 39

Pouchitis

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Pouchitis

MalaCards integrated aliases for Pouchitis:

Name: Pouchitis 58 54 17 71

Characteristics:

Orphanet epidemiological data:

58
pouchitis
Prevalence: 1-5/10000 (Europe);

Classifications:

Orphanet: 58  
Rare gastroenterological diseases


External Ids:

MESH via Orphanet 44 D019449
UMLS via Orphanet 72 C0376620
Orphanet 58 ORPHA217067
UMLS 71 C0376620

Summaries for Pouchitis

MalaCards based summary : Pouchitis is related to ileitis and colitis. An important gene associated with Pouchitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and Toll-Like receptor Signaling Pathways. The drugs Ciprofloxacin and Vedolizumab have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and small intestine.

Wikipedia : 74 Pouchitis is inflammation of the ileal pouch (an artificial rectum surgically created out of ileal gut... more...

Related Diseases for Pouchitis

Diseases related to Pouchitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 230)
# Related Disease Score Top Affiliating Genes
1 ileitis 30.9 TLR4 NOD2
2 colitis 30.6 TLR4 NOD2 CXCL8
3 ulcerative colitis 30.4 TLR4 NOD2 IL1RN CXCL8
4 proctitis 30.4 NOD2 LTF
5 cholangitis, primary sclerosing 30.4 TLR4 NOD2 LTF
6 crohn's colitis 30.2 NOD2 CXCL8
7 sclerosing cholangitis 30.1 TLR4 NOD2 CXCL8
8 cholangitis 30.1 TLR4 NOD2 CXCL8
9 spondylitis 30.0 NOD2 IL1RN
10 diarrhea 29.9 TLR4 NOD2 CXCL8
11 exanthem 29.8 IL1RN CXCL8
12 pyoderma 29.7 NOD2 IL1RN CXCL8
13 pyoderma gangrenosum 29.7 NOD2 IL1RN CXCL8
14 crohn's disease 29.7 TLR4 S100A9 NOD2 CXCL8
15 proteasome-associated autoinflammatory syndrome 1 29.4 TLR4 IL1RN CXCL8
16 respiratory failure 29.0 TLR4 IL1RN CXCL8
17 appendicitis 29.0 TLR4 S100A9 CXCL8
18 spondyloarthropathy 1 29.0 TLR4 S100A9 NOD2 IL1RN
19 arthritis 29.0 TLR4 NOD2 IL1RN CXCL8
20 inflammatory bowel disease 28.7 TLR4 S100A9 NOD2 LTF IL1RN CXCL8
21 familial adenomatous polyposis 10.8
22 overgrowth syndrome 10.5
23 papillomatosis, confluent and reticulated 10.4
24 peripheral nervous system disease 10.3
25 neuropathy 10.3
26 pediatric ulcerative colitis 10.3
27 cytomegalovirus infection 10.3
28 tenosynovitis 10.2 NOD2 IL1RN
29 mevalonic aciduria 10.2 NOD2 IL1RN
30 familial cold autoinflammatory syndrome 10.2 NOD2 IL1RN
31 cinca syndrome 10.2 NOD2 IL1RN
32 cluster headache 10.2
33 cytokine deficiency 10.2
34 alzheimer disease 17 10.1 S100A9 IL1RN
35 spondylarthropathy 10.1 TLR4 NOD2
36 intestinal perforation 10.1 TLR4 NOD2
37 acute diarrhea 10.1 S100A9 LTF
38 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 10.1
39 deficiency anemia 10.1
40 collagenous colitis 10.1
41 diversion colitis 10.1
42 megacolon 10.1
43 uveitis 10.1
44 iritis 10.1
45 toxic megacolon 10.1
46 adenocarcinoma 10.1
47 colonic disease 10.1
48 gastroduodenitis 10.1
49 chronic acquired demyelinating polyneuropathy 10.1
50 undetermined colitis 10.1

Graphical network of the top 20 diseases related to Pouchitis:



Diseases related to Pouchitis

Symptoms & Phenotypes for Pouchitis

Drugs & Therapeutics for Pouchitis

Drugs for Pouchitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
2 Vedolizumab Approved Phase 4 943609-66-3
3 Gastrointestinal Agents Phase 4
4 Cytochrome P-450 Enzyme Inhibitors Phase 4
5
Adalimumab Approved Phase 3 331731-18-1 16219006
6
Metronidazole Approved Phase 3 443-48-1 4173
7
Ustekinumab Approved, Investigational Phase 3 815610-63-0
8
Ursodeoxycholic acid Approved, Investigational Phase 2, Phase 3 128-13-2 31401
9
Valganciclovir Approved, Investigational Phase 3 175865-60-8 64147
10
Alicaforsen Investigational Phase 3 185229-68-9 16197724
11 Liver Extracts Phase 3
12 Anti-Inflammatory Agents Phase 3
13 Dermatologic Agents Phase 3
14 Anti-Infective Agents Phase 3
15 Antiviral Agents Phase 3
16
Clotrimazole Approved, Vet_approved Phase 1, Phase 2 23593-75-1 2812
17
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
18 Hormones Phase 1, Phase 2
19 Hormone Antagonists Phase 1, Phase 2
20 Anti-Infective Agents, Local Phase 1, Phase 2
21 Antifungal Agents Phase 1, Phase 2
22 Cytochrome P-450 CYP3A Inhibitors Phase 1, Phase 2
23 Anti-Bacterial Agents Phase 1, Phase 2
24 Antibiotics, Antitubercular Phase 1, Phase 2
25
Scopolamine Approved, Investigational 6533-68-2, 51-34-3 5184
26
Infliximab Approved 170277-31-3
27
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
28
Ethanol Approved 64-17-5 702
29
Nitazoxanide Approved, Investigational, Vet_approved 55981-09-4 41684
30
Certolizumab pegol Approved 428863-50-7
31
Inulin Approved, Investigational, Nutraceutical 9005-80-5 24763
32 Defensins
33 Bifidobacterium
34 Antibodies
35 Immunoglobulins, Intravenous
36 Immunoglobulins
37 Butylscopolammonium Bromide
38 Chicory
39 Acidophilus
40 Antitubercular Agents
41 Complement Factor H
42 Antiparasitic Agents
43 Complement System Proteins
44 Antiprotozoal Agents
45 Antimalarials
46 Bile Acids and Salts
47 Antirheumatic Agents
48 Immunosuppressive Agents
49 Immunologic Factors

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Double-blind Placebo Controlled Trial of VSL#3 in Children With Crohn's Disease Unknown status NCT00367705 Phase 4
2 Bacteria and Cytokines as Factors Modulating Visceral Afferent Processing in Irritable Bowel Syndrome: Manipulation of Intestinal Bacteria and Mucosal Cytokines by Probiotic Therapy and the Effect on Visceral Hypersensitivity Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
3 Lactobacillus Reuteri Reduces Pulmonary Exacerbations and Upper Respiratory Tract Infections in CF Patients With Mild-to-moderate Lung Disease. LR Administration Might Have a Beneficial Effect on the Disease Course of Cystic Fibrosis. Completed NCT01737983 Phase 4
4 Randomized, Double-Blind, Placebo-Controlled Study of VSL#3 Versus Placebo in the Maintenance of Remission in Crohn's Disease Completed NCT00114465 Phase 4 VSL#3
5 A Randomized, Double-Blind, Placebo-Controlled Phase 4 Study to Evaluate the Efficacy and Safety of Entyvio (Vedolizumab IV) in the Treatment of Chronic Pouchitis (EARNEST) Active, not recruiting NCT02790138 Phase 4 Vedolizumab;Ciprofloxacin;Vedolizumab Placebo
6 Probiotics in Patients With Primary Sclerosing Cholangitis and Inflammatory Bowel Disease- a Randomized Placebo-Controlled Cross-Over Trial Unknown status NCT00161148 Phase 3 Probiotics
7 Adalimumab (Humira) in the Treatment of Chronic Pouchitis Completed NCT01670240 Phase 3 Adalimumab;Placebo
8 A Randomized, Double-Blind, Placebo-Controlled Trial of the Safety and Efficacy of Topical Alicaforsen Enema in Subjects With Active, Chronic, Antibiotic Refractory Primary Idiopathic Pouchitis Completed NCT02525523 Phase 3 Alicaforsen;Placebo
9 Clinical Approaches to Ileal Pouch Dysfunction Completed NCT00293553 Phase 3
10 Prospective Multicenter Randomized Controlled Double-blind Label Study of the Prophylaxis of Recurrent Pouchitis After Fecal Microbiota Transplant in UC With Ileo-anal Anastomosis Recruiting NCT03524352 Phase 3
11 Stelara fOr ChRonic AntibioTic rEfractory pouchitiS (SOCRATES): A Belgian Open Label Multicenter Pilot-study Recruiting NCT04089345 Phase 3 Ustekinumab
12 The Role of Secondary Bile Acids in Intestinal Inflammation Recruiting NCT03724175 Phase 2, Phase 3 ursodiol (ursodeoxycholic acid, UDCA)
13 Relevance of Valganciclovir in Recurrent Bouts of Cryptogenic Inflammatory Bowel Diseases With an Infection by Cytomegalovirus Terminated NCT00237653 Phase 3 Valganciclovir
14 To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis (Pilot Study) Completed NCT02201186 Phase 2
15 The Use of Fecal Microbiota Transplantation in Patients With Ulcerative Colitis-associated Pouchitis Completed NCT02049502 Phase 2
16 Double-blinded Randomized Placebo Controlled Study: Fecal Microbiota Transplantation in the Treatment of Chronic Pouchitis Completed NCT03378921 Phase 2
17 A Pilot Study of the Safety and Efficacy of AST-120 in the Treatment of Active Pouchitis Completed NCT00583076 Phase 2 AST-120
18 A Randomized Double-Blind Trial of Perioperative Administration of Probiotics in Colorectal Cancer Patients. Completed NCT00936572 Phase 2
19 Randomized Trial of Fecal Microbiota Transplantation Versus Placebo for the Induction of Remission in Patients With Active Pouchitis Recruiting NCT03545386 Phase 2
20 An Exploratory Pilot Study Assessing the Efficacy of Fecal Microbial Transplantation for Clinical and Endoscopic Characteristics of Ileal Pouch Anal Anastomosis Patients Recruiting NCT04336319 Phase 2
21 Clotrimazole Enemas for Pouchitis in Children and Adults Suspended NCT00061282 Phase 1, Phase 2 Clotrimazole
22 A Pilot Study of the Safety and Efficacy of AST-120 in the Treatment of Antibiotic-Refractory Pouchitis Terminated NCT00583531 Phase 2 AST-120
23 Safety and Efficacy of Fecal Microbiome Transplantation (FMT) in the Treatment of Antibiotic Dependent Pouchitis (ADP) Terminated NCT02782325 Phase 1, Phase 2
24 Prevention of Pouchitis With Short-Chain Fructooligosaccharide Therapy, A Double-Blind, Placebo-Controlled Trial Completed NCT02203955 Phase 1 Short-Chain Fructooligosaccharide;Maltodextrin
25 The Interaction Between the Intestinal Microbiota, Innate Defense and Epithelial Integrity in the Development of Pouchitis: a Multifactorial Approach Unknown status NCT01202396
26 Microbiota and Immune microEnvironment in Pouchitis: Randomized Controlled Trial Oral Administration of Lactobacillus Casei DG After Ileostomy Closure in Ileal Pouch Mucosa Unknown status NCT03136419
27 Title Effect of Microbial Translocation and Supplementation With the Probiotic VSL#3 on Neuro-cognitive Functions of HIV Positive Patients Receiving HAART Unknown status NCT02276326
28 Fecal Microbiota Transplantation for the Treatment of Chronic Pouchitis Completed NCT03538366
29 Fecal Microbiota Transplant (FMT) for Pouchitis Completed NCT02428361 Early Phase 1 Biologically active human fecal material, OpenBiome
30 Evaluating the Nutritional Impact of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects With Ileal Pouch-Anal Anastomosis Completed NCT02828410
31 Ileal Pouch-anal Anastomosis or Ileo-rectal Anastomosis for Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis? Completed NCT01798953
32 Pelvic Collections on MRI in Patients With Ileal Pouches, and a Feasibility Study of Dynamic MRI Enema and Defaecating MRI Pouchography Completed NCT02925260
33 Critical Assessment of Routine Surveillance of Asymptomatic Patients With Ulcerative Colitis With Ileal Pouch-anal Anastomosis and Risk Factors for Dysplasia - is There a Rationale? Completed NCT01764542
34 Ileal Pouch Salvage and Excision Operations: Indications, Complications and Outcomes Completed NCT03952195
35 Correlation of Infliximab Levels With Outcomes in Ulcerative Colitis Completed NCT02438410
36 A Pilot Study of Oral Probiotic Bacteria Supplementation to Reduce Microbial Translocation and Chronic Immune Activation in HIV-infected Malian Women Completed NCT02448238
37 Open-Label Trial of a Prebiotic Preparation Containing Inulin and Oligofructose (Synergy-1) for the Treatment of Mild to Moderate Acute Ulcerative Colitis Completed NCT02093767
38 The Effect of Faecal Microbiota Transplantation in the Treatment of Chronic Pouchitis: A Multicentre, Placebo-controlled, Randomized, Double Blinded Trial Recruiting NCT04100291
39 Prospective Dietary Therapy Using Crohn's Disease Exclusion Diet ("CDED") for Ileal Pouch Anal Anastomosis ("IPAA") Patients With Endoscopic Deterioration or Clinically Suspected Pouchitis Recruiting NCT04327219
40 Biomarker-based Multidisciplinary Team Approach to Personalized Microbial-targeted Treatment of Pouchitis and Crohn's Disease Recruiting NCT04082559
41 Safety and Efficacy of Fecal Microbiota Transplantation: A Pilot Study Recruiting NCT04014413
42 Development of an Effective Treatment of Cryptosporidiosis in Bangladeshi Children Recruiting NCT04103216
43 The Effect of VSL#3 (Original De Simone Formulation) Probiotic Preparation on the Bile Acid Metabolism in Patients With Inflammatory Bowel Disease Active, not recruiting NCT01765439
44 Hyperbaric Oxygen Therapy for Antibiotic Refractory Pouchitis: a Phase 2A Clinical Trial Not yet recruiting NCT03526796
45 Epidemiologic, Clinical, Endoscopic and Histological Database of Patients With Inflammatory Bowel Disease (IBD) Not yet recruiting NCT01266538
46 EUS Evaluation of Perianal and Peri-rectal Fistulizing Crohn's Disease With CERTOLIZUMAB Treatment Terminated NCT01582568 Certolizumab

Search NIH Clinical Center for Pouchitis

Genetic Tests for Pouchitis

Anatomical Context for Pouchitis

MalaCards organs/tissues related to Pouchitis:

40
Colon, Liver, Small Intestine, Testes, Lung, Neutrophil, Prostate

Publications for Pouchitis

Articles related to Pouchitis:

(show top 50) (show all 1474)
# Title Authors PMID Year
1
Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease. 54 61
19079235 2008
2
Pouch-ouch. 61 54
18043236 2008
3
The assessment of a rapid noninvasive immunochromatographic assay test for fecal lactoferrin in patients with suspected inflammation of the ileal pouch. 54 61
18085334 2008
4
Pilot study on the effect of reducing dietary FODMAP intake on bowel function in patients without a colon. 54 61
17828776 2007
5
Differential expression of toll-like receptor 3 and 5 in ileal pouch mucosa of ulcerative colitis patients. 54 61
16770571 2007
6
The expression patterns of Toll-like receptors in the ileal pouch mucosa of postoperative ulcerative colitis patients. 61 54
16493544 2006
7
Combined carriership of TLR9-1237C and CD14-260T alleles enhances the risk of developing chronic relapsing pouchitis. 61 54
16437636 2005
8
Innate immune receptor genetic polymorphisms in pouchitis: is CARD15 a susceptibility factor? 61 54
16239841 2005
9
Fecal lactoferrin for diagnosis of symptomatic patients with ileal pouch-anal anastomosis. 61 54
15131788 2004
10
Biliary lactoferrin concentrations are increased in active inflammatory bowel disease: a factor in the pathogenesis of primary sclerosing cholangitis? 54 61
9791051 1998
11
Greater Peripouch Fat Area on CT Image Is Associated with Chronic Pouchitis and Pouch Failure in Inflammatory Bowel Diseases Patients. 61
32500285 2020
12
Impact of fecal microbiota transplantation on chronic recurrent pouchitis in ulcerative colitis with ileo-anal anastomosis: study protocol for a prospective, multicenter, double-blind, randomized, controlled trial. 61
32493442 2020
13
Inflammatory Pouch Conditions Are Common After Ileal Pouch Anal Anastomosis in Ulcerative Colitis Patients. 61
31587035 2020
14
Outcomes Following Pouch Formation in Paediatric Ulcerative Colitis: A Study from the Porto Group of ESPGHAN. 61
32541197 2020
15
Pyloric and foveolar type metaplasia are important diagnostic features in Crohn's disease that are frequently missed in routine pathology. 61
31538655 2020
16
Consumption of yoghurt favours remission after faecal microbiota transplantation for chronic pouchitis. 61
32504332 2020
17
Ileal pouch-anal anastomosis for ulcerative colitis: long-term outcomes and trends over time in a low-volume institution. 61
32472241 2020
18
High Abundance of Proteobacteria in Ileo-Anal Pouch Anastomosis and Increased Abundance of Fusobacteria Associated with Increased Pouch Inflammation. 61
32397087 2020
19
Obesity Is Associated with Decreased Risk of Clostridium difficile Infection in Hospitalized Patients with Pouchitis. 61
31617129 2020
20
Mixed Bag: How C. Difficile Can Cause Pouchitis. 61
31828463 2020
21
IBD Microbial Metabolome: The Good, Bad, and Unknown. 61
32456844 2020
22
An Update on the Medical Management of Inflammatory Pouch Complications. 61
32453044 2020
23
A New Rat Model of Pouchitis After Proctocolectomy and Ileal Pouch-Anal Anastomosis Using 2,4,6-Trinitrobenzene Sulfonic Acid. 61
32424688 2020
24
Clinical results and microbiota changes after faecal microbiota transplantation for chronic pouchitis: a pilot study. 61
32285709 2020
25
Liver transplantation for fulminant herpes simplex hepatitis in a patient treated with adalimumab for chronic pouchitis. 61
32267914 2020
26
Pouchitis: Treatment dilemmas at different stages of the disease. 61
32213019 2020
27
Promise of Fecal Microbiota Transplantation Therapy in Pouchitis. 61
31529413 2020
28
Fecal Microbiota Transplantation in Pouchitis: Clinical, Endoscopic, Histologic, and Microbiota Results from a Pilot Study. 61
31302808 2020
29
Endoscopic treatment of pouch inlet and afferent limb strictures: stricturotomy vs. balloon dilation. 61
32306110 2020
30
Creation of a Case-Finding Definition for Identifying Patients With Acute Pouchitis in Administrative Claims Data. 61
32147595 2020
31
Microbial-Based and Microbial-Targeted Therapies for Inflammatory Bowel Diseases. 61
32006212 2020
32
Prebiotics and Probiotics in Inflammatory Bowel Disease (IBD): Where Are We Now And Where Are We Going?Funders. 61
32164516 2020
33
Increased Quinolone-Resistant Mutations of gyrA and parC Genes after Pouchitis Treatment with Ciprofloxacin. 61
32182609 2020
34
The Importance of Accurate Phenotyping and Pouchitis Risk and Dietary Assessment When Investigating the Microbial Factors Behind Antibiotic-Dependent Pouchitis. 61
32234300 2020
35
Long-Term Bowel Function and Fate of the Ileal Pouch After Restorative Proctocolectomy in Patients With Crohn's Disease: A Systematic Review With Meta-Analysis and Metaregression. 61
31412119 2020
36
A case of refractory chronic pouchitis successfully treated with tofacitinib. 61
32130659 2020
37
Predominantly Antibiotic-resistant Intestinal Microbiome Persists in Patients With Pouchitis Who Respond to Antibiotic Therapy. 61
31605691 2020
38
DIAGNOSTIC AND MANAGEMENT APPROACH TO POUCHITIS IN INFLAMMATORY BOWEL DISEASE. 61
32130304 2020
39
Short-term Results After Totally Robotic Restorative Total Proctocolectomy With Ileal Pouch Anal Anastomosis for Ulcerative Colitis. 61
30768495 2020
40
Diet-Microbiome Interactions and the Risk of Pouchitis in Ileal Pouch-Anal Anastomosis. 61
31605607 2020
41
Exposing the Achilles Heel of Antibiotic Therapy for Pouchitis Using Microbial Function and Composition. 61
31863743 2020
42
Outcome of Ileal Pouch Anal Anastomosis in Patients with Indeterminate Colitis: A Systematic Review and Meta-analysis. 61
31912129 2020
43
Letter: is measurement of faecal biomarkers helpful for the early diagnosis and prediction of pouchitis after proctocolectomy for ulcerative colitis? 61
31850563 2020
44
The Structure and Function of the Human Small Intestinal Microbiota: Current Understanding and Future Directions. 61
31344510 2020
45
Impact of preoperative duration of ulcerative colitis on long-term outcomes of restorative proctocolectomy. 61
31760437 2020
46
Letter: is measurement of faecal biomarkers helpful for the early diagnosis and prediction of pouchitis after proctocolectomy for ulcerative colitis? Authors' reply. 61
31850582 2020
47
DIAGNOSTIC AND MANAGEMENT APPROACH TO POUCHITIS IN INFLAMMATORY BOWEL DISEASE. 61
32294743 2020
48
Pouchitis: diagnosis and management. 61
31599752 2020
49
Prolyl Hydroxylase Inhibition Mitigates Pouchitis. 61
31618435 2020
50
Antibiotics and probiotics in inflammatory bowel disease: when to use them? 61
31885842 2020

Variations for Pouchitis

Expression for Pouchitis

Search GEO for disease gene expression data for Pouchitis.

Pathways for Pouchitis

Pathways related to Pouchitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.23 TLR4 S100A9 NOD2 LTF IL1RN CXCL8
2
Show member pathways
11.56 TLR4 NOD2 IL1RN CXCL8
3 11.39 TLR4 NOD2 CXCL8
4 11.28 TLR4 CXCL8
5 11.12 TLR4 CXCL8
6 11.02 TLR4 CXCL8
7 10.95 IL1RN CXCL8

GO Terms for Pouchitis

Biological processes related to Pouchitis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.78 TLR4 S100A9 NOD2 LTF
2 immune response GO:0006955 9.77 TLR4 IL1RN CXCL8
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.61 TLR4 NOD2 LTF
4 neutrophil chemotaxis GO:0030593 9.6 S100A9 CXCL8
5 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.58 TLR4 NOD2
6 antimicrobial humoral response GO:0019730 9.58 S100A9 LTF
7 cellular response to lipopolysaccharide GO:0071222 9.58 TLR4 NOD2 CXCL8
8 positive regulation of interleukin-6 production GO:0032755 9.57 TLR4 NOD2
9 positive regulation of tumor necrosis factor production GO:0032760 9.56 TLR4 NOD2
10 inflammatory response GO:0006954 9.56 TLR4 S100A9 IL1RN CXCL8
11 toll-like receptor signaling pathway GO:0002224 9.55 TLR4 S100A9
12 positive regulation of interleukin-1 beta secretion GO:0050718 9.54 TLR4 NOD2
13 positive regulation of interleukin-8 production GO:0032757 9.52 TLR4 NOD2
14 positive regulation of interleukin-10 production GO:0032733 9.51 TLR4 NOD2
15 regulation of inflammatory response GO:0050727 9.5 TLR4 S100A9 NOD2
16 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.49 TLR4 NOD2
17 positive regulation of stress-activated MAPK cascade GO:0032874 9.46 TLR4 NOD2
18 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.37 TLR4 NOD2
19 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.33 S100A9 LTF CXCL8
20 defense response to bacterium GO:0042742 9.26 TLR4 S100A9 NOD2 LTF
21 positive regulation of NF-kappaB transcription factor activity GO:0051092 8.92 TLR4 S100A9 NOD2 LTF

Molecular functions related to Pouchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.62 TLR4 LTF

Sources for Pouchitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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