Aliases & Classifications for Pouchitis

MalaCards integrated aliases for Pouchitis:

Name: Pouchitis 60 56 17 74

Characteristics:

Orphanet epidemiological data:

60
pouchitis
Prevalence: 1-5/10000 (Europe);

Classifications:



External Ids:

MESH via Orphanet 46 D019449
UMLS via Orphanet 75 C0376620
Orphanet 60 ORPHA217067
UMLS 74 C0376620

Summaries for Pouchitis

MalaCards based summary : Pouchitis is related to ileitis and colitis. An important gene associated with Pouchitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Vedolizumab and Ciprofloxacin have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and neutrophil, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 Pouchitis is inflammation of the ileal pouch (an artificial rectum surgically created out of ileal gut... more...

Related Diseases for Pouchitis

Diseases related to Pouchitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
# Related Disease Score Top Affiliating Genes
1 ileitis 30.7 NOD2 TLR4
2 colitis 30.4 CXCL8 IL10 NOD2 TLR4
3 ulcerative colitis 30.4 CXCL8 IL10 NOD2 TLR4
4 pyoderma gangrenosum 30.3 CXCL8 NOD2
5 pyoderma 30.3 CXCL8 NOD2
6 inflammatory bowel disease 29.7 CXCL8 IL10 NOD2 TLR4
7 arthritis 29.5 CXCL8 IL10 IL1RN NOD2
8 uveitis 29.4 IL10 NOD2
9 crohn's disease 10.3
10 familial adenomatous polyposis 10.3
11 cytomegalovirus infection 10.2
12 hypersensitivity reaction type iv disease 10.2 IL1RN NOD2
13 spondylarthropathy 10.2 NOD2 TLR4
14 inflammatory bowel disease 6 10.2 NOD2 TLR4
15 cholangitis, primary sclerosing 10.2
16 sclerosing cholangitis 10.2
17 cholangitis 10.2
18 neisseria meningitidis infection 10.2 IL1RN TLR4
19 sapho syndrome 10.1 CXCL8 NOD2
20 crohn's colitis 10.1 CXCL8 NOD2
21 familial mediterranean fever 10.1 IL1RN NOD2
22 adenocarcinoma 10.1
23 pediatric ulcerative colitis 10.1
24 necrotizing fasciitis 10.1 CXCL8 IL1RN
25 spondyloarthropathy 1 10.1 NOD2 TLR4
26 felty syndrome 10.1 CXCL8 LTF
27 giant papillary conjunctivitis 10.1 CXCL8 LTF
28 haemophilus influenzae 10.1 CXCL8 LTF
29 superficial urinary bladder cancer 10.1 CXCL8 TLR4
30 bronchopulmonary dysplasia 10.1 CXCL8 IL1RN
31 endometrial disease 10.1 CXCL8 TLR4
32 pyelitis 10.1 CXCL8 TLR4
33 periodontosis 10.1 CXCL8 TLR4
34 gastric ulcer 10.1 CXCL8 IL1RN
35 spondylitis 10.1 IL1RN NOD2
36 bacteriuria 10.1 CXCL8 TLR4
37 septic arthritis 10.1 CXCL8 TLR4
38 oral candidiasis 10.1 CXCL8 LTF
39 middle ear disease 10.1 CXCL8 TLR4
40 silicosis 10.1 CXCL8 IL1RN
41 perinatal necrotizing enterocolitis 10.0 CXCL8 TLR4
42 invasive aspergillosis 10.0 CXCL8 TLR4
43 atrophic gastritis 10.0 CXCL8 IL1RN
44 bacterial vaginosis 10.0 CXCL8 TLR4
45 duodenal ulcer 10.0 CXCL8 IL1RN
46 deficiency anemia 10.0
47 bacterial pneumonia 10.0 CXCL8 TLR4
48 orofacial granulomatosis 10.0 IL10 NOD2
49 gaucher disease, type ii 10.0 IL10 IL1RN
50 leprosy 3 10.0 IL10 NOD2

Graphical network of the top 20 diseases related to Pouchitis:



Diseases related to Pouchitis

Symptoms & Phenotypes for Pouchitis

GenomeRNAi Phenotypes related to Pouchitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.23 NOD2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.23 IL10
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.23 IL10
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.23 IL10
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.23 IL10
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.23 IL10 NOD2 TLR4

Drugs & Therapeutics for Pouchitis

Drugs for Pouchitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vedolizumab Approved Phase 4 943609-66-3
2
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
3 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
4 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
5 Gastrointestinal Agents Phase 4,Phase 3
6 Cytochrome P-450 Enzyme Inhibitors Phase 4
7 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
8 Topoisomerase Inhibitors Phase 4
9
Adalimumab Approved Phase 3 331731-18-1 16219006
10
Ursodeoxycholic acid Approved, Investigational Phase 3 128-13-2 31401
11
Alicaforsen Investigational Phase 3 185229-68-9 16197724
12 Antirheumatic Agents Phase 3
13 Anti-Inflammatory Agents Phase 3
14 Immunosuppressive Agents Phase 3
15 Immunologic Factors Phase 3,Not Applicable
16 Antibiotics, Antitubercular Phase 3,Phase 1,Phase 2,Not Applicable
17 Bile Acids and Salts Phase 3
18 Cholagogues and Choleretics Phase 3
19
Clotrimazole Approved, Vet_approved Phase 1, Phase 2 23593-75-1 2812
20 Antitubercular Agents Phase 2
21
Scopolamine Approved, Investigational 6533-68-2, 51-34-3 5184
22
Certolizumab pegol Approved 428863-50-7
23 Defensins
24 Immunoglobulins Not Applicable
25 Antibodies Not Applicable
26 Acidophilus Not Applicable
27 Butylscopolammonium Bromide

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 VSL#3 Treatment in Children With Crohn's Disease Unknown status NCT00367705 Phase 4
2 Phase 4 Study to Evaluate the Efficacy and Safety of Vedolizumab in the Treatment of Chronic Pouchitis Recruiting NCT02790138 Phase 4 Vedolizumab;Ciprofloxacin;Vedolizumab Placebo
3 Adalimumab in the Treatment of Chronic Pouchitis Completed NCT01670240 Phase 3 Adalimumab;Placebo
4 Efficacy of Alicaforsen in Pouchitis Patients Who Have Failed to Respond to at Least One Course of Antibiotics Completed NCT02525523 Phase 3 Alicaforsen;Placebo
5 Clinical Approaches to Ileal Pouch Dysfunction Completed NCT00293553 Phase 3
6 the Prophylaxis of Recurrent Pouchitis After Fecal Microbiota Transplant in UC With Ileo-anal Anastomosis Recruiting NCT03524352 Phase 3
7 The Role of Secondary Bile Acids in Intestinal Inflammation Not yet recruiting NCT03724175 Phase 3 ursodiol (ursodeoxycholic acid, UDCA)
8 To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis Completed NCT02201186 Phase 2
9 FMT in Ulcerative Colitis-Associated Pouchitis Completed NCT02049502 Phase 2
10 Safety and Efficacy of AST-120 in the Treatment of Pouchitis Completed NCT00583076 Phase 2 AST-120
11 Fecal Microbiota Transplantation in the Treatment of Pouchitis Active, not recruiting NCT03378921 Phase 2
12 Safety and Efficacy of Fecal Microbiome Transplantation (FMT) in the Treatment of Antibiotic Dependent Pouchitis (ADP) Active, not recruiting NCT02782325 Phase 1, Phase 2
13 Fecal Microbiota Transplantation for Pouchitis Not yet recruiting NCT03545386 Phase 2
14 Clotrimazole Enemas for Pouchitis in Children and Adults Suspended NCT00061282 Phase 1, Phase 2 Clotrimazole
15 Safety and Efficacy of AST-120 in the Treatment of Antibiotic-Refractory Pouchitis Terminated NCT00583531 Phase 2 AST-120
16 Study of Sc-FOS for Pouchitis Prevention Active, not recruiting NCT02203955 Phase 1 Short-Chain Fructooligosaccharide;Maltodextrin
17 The Interaction Between Intestinal Microbiota, Innate Defense and Epithelial Integrity in the Development of Pouchitis Unknown status NCT01202396
18 Clinical Outcome After Close Rectal Ileo Pouch Anal Anastomosis for Colitis Ulcerosa(CU) Unknown status NCT01111708 Not Applicable
19 The Effect of Diet on Microbial Profile and Disease Outcomes in Patients With Inflammatory Bowel Diseases Unknown status NCT02858557 Not Applicable
20 Nutritional Impact of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects With IPAA Completed NCT02828410 Not Applicable
21 Surgical Reconstruction in Ulcerative Colitis With Primary Sclerosing Cholangitis Completed NCT01798953
22 Characterization of Disease Related Changes in Inflammatory Bowel Disease Using Fecal Metabolite Profiling Completed NCT01666717
23 Fecal Transplantation for Chronic Pouchitis - A Pilot Study Recruiting NCT03538366 Not Applicable
24 Microbiota and Immune microEnvironment in Pouchitis Recruiting NCT03136419 Not Applicable
25 MRI in Normal Ileal Pouches, and a Feasibility Study of Dynamic MRI Enema and Defaecating MRI Pouchography Recruiting NCT02925260
26 TAMIS-IPAA vs. Lap-IPAA for Ulcerative Colitiis Recruiting NCT03536988 Not Applicable
27 Fecal Microbiota Transplant (FMT) for Pouchitis Active, not recruiting NCT02428361 Early Phase 1 Biologically active human fecal material, OpenBiome
28 Corrona Inflammatory Bowel Disease (IBD) Registry Enrolling by invitation NCT03162549
29 Hyperbaric Oxygen Therapy for Antibiotic Refractory Pouchitis Not yet recruiting NCT03526796 Not Applicable
30 EUS Evaluation of Perianal and Peri-rectal Fistulizing Crohn's Disease With CERTOLIZUMAB Treatment Terminated NCT01582568 Certolizumab
31 Ileal Pouch-Anal Anastomosis Registry Terminated NCT01026480

Search NIH Clinical Center for Pouchitis

Genetic Tests for Pouchitis

Anatomical Context for Pouchitis

MalaCards organs/tissues related to Pouchitis:

42
Colon, Liver, Neutrophil, Small Intestine, Testes, Prostate, Monocytes

Publications for Pouchitis

Articles related to Pouchitis:

(show top 50) (show all 454)
# Title Authors Year
1
Predictors for Pouchitis After Ileal Pouch-Anal Anastomosis for Pediatric-Onset Ulcerative Colitis. ( 30743232 )
2019
2
The therapy of chronic pouchitis. ( 30623632 )
2019
3
Adalimumab in the treatment of chronic pouchitis. A randomized double-blind, placebo-controlled trial. ( 30739519 )
2019
4
Efficacy of Vedolizumab for Refractory Pouchitis of the Ileo-anal Pouch: Results From a Multicenter US Cohort. ( 30810748 )
2019
5
Fruit consumption is associated with alterations in microbial composition and lower rates of pouchitis. ( 30828722 )
2019
6
Management of Pouchitis and Other Common Complications of the Pouch. ( 29688472 )
2018
7
Diversion colitis and pouchitis: A mini-review. ( 29713128 )
2018
8
Reliability among central readers in the evaluation of endoscopic disease activity in pouchitis. ( 29660321 )
2018
9
Systematic Review With Meta-Analysis: Anti-TNF Therapy in Refractory Pouchitis and Crohn's Disease-Like Complications of the Pouch After Ileal Pouch-Anal Anastomosis Following Colectomy for Ulcerative Colitis. ( 29361101 )
2018
10
Editorial: biologic therapy for chronic pouchitis - are we beginning to meet the unmet need? ( 29446134 )
2018
11
Effective use of ustekinumab for prepouch ileitis without improvement of concomitant pouchitis. ( 29423578 )
2018
12
Long-term follow-up of the use of maintenance antibiotic therapy for chronic antibiotic-dependent pouchitis. ( 29588846 )
2018
13
Vedolizumab in the treatment of chronic, antibiotic-dependent or refractory pouchitis. ( 29266360 )
2018
14
How do you treat this diversion ileitis and pouchitis? ( 29588334 )
2018
15
Pouchitis as an Indication for Ileal Pouch Surgical Revision. ( 29939252 )
2018
16
Use of vedolizumab in a patient with chronic and refractory pouchitis. ( 29720865 )
2018
17
Festschrift for Ronan O'Connell: pouchitis, ulcerative colitis and the microbiome. ( 29524104 )
2018
18
Another RESIN for Pouchitis: Chronic Pouchitis With Erosion Secondary to Sodium Polystyrene Sulfonate Crystals. ( 29535436 )
2018
19
Ustekinumab Rescue Therapy in a Patient with Chronic Refractory Pouchitis. ( 29659775 )
2018
20
Smoking and the Risk of Pouchitis in Ulcerative Colitis Patients With Ileal Pouch-Anal Anastomosis. ( 29788269 )
2018
21
Successful treatment with tacrolimus of refractory pyoderma gangrenosum with pouchitis after restorative proctocolectomy for ulcerative colitis. ( 30618342 )
2018
22
Early first episode of pouchitis after ileal pouch-anal anastomosis for pediatric ulcerative colitis is a risk factor for development of chronic pouchitis. ( 30446392 )
2018
23
Response to the Letter to the Editor from Dai et al, Regarding "Smoking and the Risk of Pouchitis in Ulcerative Colitis Patients with Ileal Pouch Anal Anastomosis". ( 30124832 )
2018
24
The Effect of Smoking on the Risk of Pouchitis in Ulcerative Colitis Patients With Ileal Pouch-anal Anastomosis. ( 30124837 )
2018
25
Refractory Chronic Pouchitis and Autoimmune Hemolytic Anemia Successfully Treated with Vedolizumab. ( 30480056 )
2018
26
Placebo Rates in Randomized Controlled Trials of Pouchitis Therapy. ( 29995184 )
2018
27
Identifying Outcomes in Clinical Trials of Pouchitis for the Development of a Core Outcome Set. ( 30268563 )
2018
28
Central Serous Chorioretinopathy in a Patient with Ulcerative Colitis with Pouchitis on Budesonide-EC. ( 28328626 )
2017
29
NOD2 genetic variants predispose one of two familial adenomatous polyposis siblings to pouchitis through microbiome dysbiosis. ( 28633443 )
2017
30
Lactobacillus acidophilus alleviates pouchitis after ileal pouch-anal anastomosis in rats. ( 28765694 )
2017
31
Intestinal Barrier Disruption in Ileal Pouchitis After Ileal Pouch-Anal Anastomosis in a Rat Model. ( 28486255 )
2017
32
Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis. ( 28248733 )
2017
33
Cryptosporidium Pouchitis. ( 28223201 )
2017
34
Endoscopic Treatment of Bleeding Diversion Pouchitis with High-Concentration Dextrose Spray. ( 28377939 )
2017
35
Frequency and Risk Factors of Clostridium difficile Infection in Hospitalized Patients With Pouchitis: A Population-based Study. ( 28296825 )
2017
36
Refractory pouchitis improves after administration of the green tea polyphenol EGCG: a retrospective review. ( 28929216 )
2017
37
Pouchitis after ileal pouch-anal anastomosis in ulcerative colitis: Diagnosis, management, risk factors, and incidence. ( 27681447 )
2017
38
Abdominal Visceral Fat Area and Chronic Pouchitis after Ileal Pouch-Anal Anastomosis. ( 29391089 )
2017
39
Preoperative Extraintestinal Manifestations Associated with Chronic Pouchitis in Japanese Patients with Ulcerative Colitis After Ileal Pouch-anal Anastomosis: A Retrospective Study. ( 28346273 )
2017
40
Combination therapy with vedolizumab and etanercept in a patient with pouchitis and spondylarthritis. ( 28243458 )
2017
41
Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis. ( 28221248 )
2017
42
Efficacy of granulocyte and monocyte apheresis for antibiotic-refractory pouchitis after proctocolectomy for ulcerative colitis: an open-label, prospective, multicentre study. ( 28203278 )
2017
43
Colonic Histological Criteria Predict Development of Pouchitis after Ileal Pouch: Anal Anastomosis for Patients with Ulcerative Colitis. ( 28662525 )
2017
44
Tripterygium wilfordii polyglycosidium ameliorates pouchitis induced by dextran sulfate sodium in rats. ( 27988458 )
2017
45
Successful Treatment With Ustekinumab for Chronic Refractory Pouchitis. ( 28199485 )
2017
46
Successful treatment of chronic refractory pouchitis with vedolizumab. ( 28698974 )
2017
47
Sulfasalazine in Prevention of Pouchitis After Proctocolectomy with Ileal Pouch-Anal Anastomosis for Ulcerative Colitis. ( 28110377 )
2017
48
Successful treatment of pouchitis with Vedolizumab, but not fecal microbiota transfer (FMT), after proctocolectomy in ulcerative colitis. ( 28097380 )
2017
49
Predictors of pouchitis after ileal pouch-anal anastomosis in pediatric-onset ulcerative colitis. ( 28542114 )
2017
50
Efficacy of Vedolizumab in Patients with Antibiotic and Anti-tumor Necrosis Alpha Refractory Pouchitis. ( 27930413 )
2017

Variations for Pouchitis

Expression for Pouchitis

Search GEO for disease gene expression data for Pouchitis.

Pathways for Pouchitis

GO Terms for Pouchitis

Biological processes related to Pouchitis according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.82 CXCL8 IL10 IL1RN
2 cytokine-mediated signaling pathway GO:0019221 9.78 CXCL8 IL10 IL1RN
3 immune response GO:0006955 9.73 CXCL8 IL10 IL1RN TLR4
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.67 LTF NOD2 TLR4
5 defense response to Gram-negative bacterium GO:0050829 9.66 LTF TLR4
6 neutrophil chemotaxis GO:0030593 9.65 CXCL8 IL1RN
7 regulation of inflammatory response GO:0050727 9.65 NOD2 TLR4
8 response to glucocorticoid GO:0051384 9.64 IL10 IL1RN
9 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.64 CXCL8 LTF
10 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.63 NOD2 TLR4
11 positive regulation of tumor necrosis factor production GO:0032760 9.63 NOD2 TLR4
12 interleukin-1-mediated signaling pathway GO:0070498 9.62 IL1RN NOD2
13 negative regulation of tumor necrosis factor production GO:0032720 9.62 IL10 TLR4
14 inflammatory response GO:0006954 9.62 CXCL8 IL10 IL1RN TLR4
15 negative regulation of interferon-gamma production GO:0032689 9.6 IL10 TLR4
16 negative regulation of interleukin-6 production GO:0032715 9.59 IL10 TLR4
17 positive regulation of interleukin-1 beta secretion GO:0050718 9.58 NOD2 TLR4
18 positive regulation of interleukin-8 production GO:0032757 9.58 NOD2 TLR4
19 leukocyte chemotaxis GO:0030595 9.57 CXCL8 IL10
20 positive regulation of interleukin-10 production GO:0032733 9.56 NOD2 TLR4
21 positive regulation of stress-activated MAPK cascade GO:0032874 9.55 NOD2 TLR4
22 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.54 NOD2 TLR4
23 positive regulation of JNK cascade GO:0046330 9.54 IL1RN NOD2 TLR4
24 positive regulation of macrophage activation GO:0043032 9.52 IL10 TLR4
25 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.51 NOD2 TLR4
26 response to molecule of bacterial origin GO:0002237 9.48 CXCL8 IL10
27 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.46 IL10 IL1RN
28 defense response to bacterium GO:0042742 9.46 IL10 LTF NOD2 TLR4
29 positive regulation of interleukin-6 production GO:0032755 9.43 IL1RN NOD2 TLR4
30 positive regulation of MHC class II biosynthetic process GO:0045348 9.4 IL10 TLR4
31 response to activity GO:0014823 9.31 IL10
32 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.26 IL1RN LTF NOD2 TLR4
33 cellular response to lipopolysaccharide GO:0071222 9.02 CXCL8 IL10 IL1RN NOD2 TLR4

Molecular functions related to Pouchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.96 LTF TLR4
2 cytokine activity GO:0005125 8.8 CXCL8 IL10 IL1RN

Sources for Pouchitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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