Aliases & Classifications for Pouchitis

MalaCards integrated aliases for Pouchitis:

Name: Pouchitis 59 55 17 72

Characteristics:

Orphanet epidemiological data:

59
pouchitis
Prevalence: 1-5/10000 (Europe);

Classifications:



External Ids:

MESH via Orphanet 45 D019449
UMLS via Orphanet 73 C0376620
Orphanet 59 ORPHA217067
UMLS 72 C0376620

Summaries for Pouchitis

MalaCards based summary : Pouchitis is related to ileitis and crohn's colitis. An important gene associated with Pouchitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Ciprofloxacin and Vedolizumab have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and small intestine.

Wikipedia : 75 Pouchitis is inflammation of the ileal pouch (an artificial rectum surgically created out of ileal gut... more...

Related Diseases for Pouchitis

Diseases related to Pouchitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
# Related Disease Score Top Affiliating Genes
1 ileitis 31.4 TLR4 NOD2
2 crohn's colitis 30.6 NOD2 CXCL8
3 pyoderma 30.5 NOD2 CXCL8
4 pyoderma gangrenosum 30.5 NOD2 CXCL8
5 ulcerative colitis 30.2 TLR4 NOD2 IL10 CXCL8
6 spondyloarthropathy 1 30.1 TLR4 NOD2
7 spondylitis 30.0 NOD2 IL1RN
8 colitis 29.9 TLR4 NOD2 IL10 CXCL8
9 inflammatory bowel disease 29.6 TLR4 NOD2 IL10 CXCL8
10 appendicitis 29.5 IL10 CXCL8
11 uveitis 29.5 NOD2 IL10
12 peritonitis 29.2 IL10 CXCL8
13 arthritis 28.8 NOD2 IL1RN IL10 CXCL8
14 proteasome-associated autoinflammatory syndrome 1 28.7 TLR4 IL1RN IL10 CXCL8
15 familial adenomatous polyposis 10.8
16 crohn's disease 10.7
17 sclerosing cholangitis 10.5
18 cholangitis 10.5
19 cholangitis, primary sclerosing 10.5
20 overgrowth syndrome 10.5
21 papillomatosis, confluent and reticulated 10.4
22 diarrhea 10.4
23 hypersensitivity reaction type iv disease 10.3 NOD2 IL1RN
24 spondylarthropathy 10.3 TLR4 NOD2
25 inflammatory bowel disease 6 10.3 TLR4 NOD2
26 pediatric ulcerative colitis 10.3
27 cytomegalovirus infection 10.3
28 neisseria meningitidis infection 10.3 TLR4 IL1RN
29 sapho syndrome 10.2 NOD2 CXCL8
30 peripheral nervous system disease 10.2
31 neuropathy 10.2
32 necrotizing fasciitis 10.2 IL1RN CXCL8
33 familial mediterranean fever 10.2 NOD2 IL1RN
34 proctitis 10.2
35 cytokine deficiency 10.2
36 giant papillary conjunctivitis 10.1 LTF CXCL8
37 felty syndrome 10.1 LTF CXCL8
38 haemophilus influenzae 10.1 LTF CXCL8
39 superficial urinary bladder cancer 10.1 TLR4 CXCL8
40 periodontosis 10.1 TLR4 CXCL8
41 bronchopulmonary dysplasia 10.1 IL1RN CXCL8
42 pyelitis 10.1 TLR4 CXCL8
43 endometrial disease 10.1 TLR4 CXCL8
44 gastric ulcer 10.1 IL1RN CXCL8
45 bacteriuria 10.1 TLR4 CXCL8
46 septic arthritis 10.1 TLR4 CXCL8
47 oral candidiasis 10.1 LTF CXCL8
48 middle ear disease 10.1 TLR4 CXCL8
49 perinatal necrotizing enterocolitis 10.1 TLR4 CXCL8
50 silicosis 10.1 IL1RN CXCL8

Graphical network of the top 20 diseases related to Pouchitis:



Diseases related to Pouchitis

Symptoms & Phenotypes for Pouchitis

Drugs & Therapeutics for Pouchitis

Drugs for Pouchitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
2 Vedolizumab Approved Phase 4 943609-66-3
3 Acidophilus Phase 4
4 Gastrointestinal Agents Phase 4
5 Cytochrome P-450 Enzyme Inhibitors Phase 4
6 Topoisomerase Inhibitors Phase 4
7 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
8
Adalimumab Approved Phase 3 331731-18-1 16219006
9
Ursodeoxycholic acid Approved, Investigational Phase 2, Phase 3 128-13-2 31401
10
Valganciclovir Approved, Investigational Phase 3 175865-60-8 64147
11
Alicaforsen Investigational Phase 3 185229-68-9 16197724
12 Liver Extracts Phase 3
13 Anti-Inflammatory Agents Phase 3
14 Cholagogues and Choleretics Phase 2, Phase 3
15 Bile Acids and Salts Phase 2, Phase 3
16 Anti-Infective Agents Phase 3
17 Antiviral Agents Phase 3
18
Clotrimazole Approved, Vet_approved Phase 1, Phase 2 23593-75-1 2812
19 Antibiotics, Antitubercular Phase 2
20 Anti-Bacterial Agents Phase 1, Phase 2
21 Antitubercular Agents Phase 2
22
Scopolamine Approved, Investigational 6533-68-2, 51-34-3 5184
23
Infliximab Approved 170277-31-3
24
Ethanol Approved 64-17-5 702
25
Certolizumab pegol Approved 428863-50-7
26
Inulin Approved, Investigational, Nutraceutical 9005-80-5 24763
27 Defensins
28 Butylscopolammonium Bromide
29 Bifidobacterium
30 Antibodies
31 Immunoglobulins
32 Chicory
33 Dermatologic Agents
34 Antirheumatic Agents
35 Immunologic Factors
36 Immunosuppressive Agents

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 Double-blind Placebo Controlled Trial of VSL#3 in Children With Crohn's Disease Unknown status NCT00367705 Phase 4
2 Bacteria and Cytokines as Factors Modulating Visceral Afferent Processing in Irritable Bowel Syndrome: Manipulation of Intestinal Bacteria and Mucosal Cytokines by Probiotic Therapy and the Effect on Visceral Hypersensitivity Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
3 Lactobacillus Reuteri Reduces Pulmonary Exacerbations and Upper Respiratory Tract Infections in CF Patients With Mild-to-moderate Lung Disease. LR Administration Might Have a Beneficial Effect on the Disease Course of Cystic Fibrosis. Completed NCT01737983 Phase 4
4 Randomized, Double-Blind, Placebo-Controlled Study of VSL#3 Versus Placebo in the Maintenance of Remission in Crohn's Disease Completed NCT00114465 Phase 4 VSL#3
5 A Randomized, Double-Blind, Placebo-Controlled Phase 4 Study to Evaluate the Efficacy and Safety of Entyvio (Vedolizumab IV) in the Treatment of Chronic Pouchitis (EARNEST) Recruiting NCT02790138 Phase 4 Vedolizumab;Ciprofloxacin;Vedolizumab Placebo
6 Probiotics in Patients With Primary Sclerosing Cholangitis and Inflammatory Bowel Disease- a Randomized Placebo-Controlled Cross-Over Trial Unknown status NCT00161148 Phase 3 Probiotics
7 Adalimumab (Humira) in the Treatment of Chronic Pouchitis Completed NCT01670240 Phase 3 Adalimumab;Placebo
8 A Randomized, Double-Blind, Placebo-Controlled Trial of the Safety and Efficacy of Topical Alicaforsen Enema in Subjects With Active, Chronic, Antibiotic Refractory Primary Idiopathic Pouchitis Completed NCT02525523 Phase 3 Alicaforsen;Placebo
9 Clinical Approaches to Ileal Pouch Dysfunction Completed NCT00293553 Phase 3
10 Prospective Multicenter Randomized Controlled Double-blind Label Study of the Prophylaxis of Recurrent Pouchitis After Fecal Microbiota Transplant in UC With Ileo-anal Anastomosis Recruiting NCT03524352 Phase 3
11 The Role of Secondary Bile Acids in Intestinal Inflammation Recruiting NCT03724175 Phase 2, Phase 3 ursodiol (ursodeoxycholic acid, UDCA)
12 Relevance of Valganciclovir in Recurrent Bouts of Cryptogenic Inflammatory Bowel Diseases With an Infection by Cytomegalovirus Terminated NCT00237653 Phase 3 Valganciclovir
13 To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis (Pilot Study) Completed NCT02201186 Phase 2
14 The Use of Fecal Microbiota Transplantation in Patients With Ulcerative Colitis-associated Pouchitis Completed NCT02049502 Phase 2
15 A Pilot Study of the Safety and Efficacy of AST-120 in the Treatment of Active Pouchitis Completed NCT00583076 Phase 2 AST-120
16 A Randomized Double-Blind Trial of Perioperative Administration of Probiotics in Colorectal Cancer Patients. Completed NCT00936572 Phase 2
17 Randomized Trial of Fecal Microbiota Transplantation Versus Placebo for the Induction of Remission in Patients With Active Pouchitis Recruiting NCT03545386 Phase 2
18 Double-blinded Randomized Placebo Controlled Study: Fecal Microbiota Transplantation in the Treatment of Chronic Pouchitis Active, not recruiting NCT03378921 Phase 2
19 Clotrimazole Enemas for Pouchitis in Children and Adults Suspended NCT00061282 Phase 1, Phase 2 Clotrimazole
20 A Pilot Study of the Safety and Efficacy of AST-120 in the Treatment of Antibiotic-Refractory Pouchitis Terminated NCT00583531 Phase 2 AST-120
21 Safety and Efficacy of Fecal Microbiome Transplantation (FMT) in the Treatment of Antibiotic Dependent Pouchitis (ADP) Terminated NCT02782325 Phase 1, Phase 2
22 Prevention of Pouchitis With Short-Chain Fructooligosaccharide Therapy, A Double-Blind, Placebo-Controlled Trial Active, not recruiting NCT02203955 Phase 1 Short-Chain Fructooligosaccharide;Maltodextrin
23 The Interaction Between the Intestinal Microbiota, Innate Defense and Epithelial Integrity in the Development of Pouchitis: a Multifactorial Approach Unknown status NCT01202396
24 Microbiota and Immune microEnvironment in Pouchitis: Randomized Controlled Trial Oral Administration of Lactobacillus Casei DG After Ileostomy Closure in Ileal Pouch Mucosa Unknown status NCT03136419
25 Pelvic Collections on MRI in Patients With Ileal Pouches, and a Feasibility Study of Dynamic MRI Enema and Defaecating MRI Pouchography Unknown status NCT02925260
26 Title Effect of Microbial Translocation and Supplementation With the Probiotic VSL#3 on Neuro-cognitive Functions of HIV Positive Patients Receiving HAART Unknown status NCT02276326
27 Fecal Transplantation for the Treatment of Chronic Pouchitis - A Pilot Study Completed NCT03538366
28 Fecal Microbiota Transplant (FMT) for Pouchitis Completed NCT02428361 Early Phase 1 Biologically active human fecal material, OpenBiome
29 Evaluating the Nutritional Impact of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects With Ileal Pouch-Anal Anastomosis Completed NCT02828410
30 Ileal Pouch-anal Anastomosis or Ileo-rectal Anastomosis for Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis? Completed NCT01798953
31 Critical Assessment of Routine Surveillance of Asymptomatic Patients With Ulcerative Colitis With Ileal Pouch-anal Anastomosis and Risk Factors for Dysplasia - is There a Rationale? Completed NCT01764542
32 Ileal Pouch Salvage and Excision Operations: Indications, Complications and Outcomes Completed NCT03952195
33 A Pilot Study of Oral Probiotic Bacteria Supplementation to Reduce Microbial Translocation and Chronic Immune Activation in HIV-infected Malian Women Completed NCT02448238
34 Open-Label Trial of a Prebiotic Preparation Containing Inulin and Oligofructose (Synergy-1) for the Treatment of Mild to Moderate Acute Ulcerative Colitis Completed NCT02093767
35 Correlation of Infliximab Levels With Outcomes in Ulcerative Colitis Recruiting NCT02438410
36 The Effect of VSL#3 (Original De Simone Formulation) Probiotic Preparation on the Bile Acid Metabolism in Patients With Inflammatory Bowel Disease Recruiting NCT01765439
37 Hyperbaric Oxygen Therapy for Antibiotic Refractory Pouchitis: a Phase 2A Clinical Trial Not yet recruiting NCT03526796
38 Epidemiologic, Clinical, Endoscopic and Histological Database of Patients With Inflammatory Bowel Disease (IBD) Not yet recruiting NCT01266538
39 Safety and Efficacy of Fecal Microbiota Transplantation: A Pilot Study Not yet recruiting NCT04014413
40 EUS Evaluation of Perianal and Peri-rectal Fistulizing Crohn's Disease With CERTOLIZUMAB Treatment Terminated NCT01582568 Certolizumab

Search NIH Clinical Center for Pouchitis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Metronidazole

Genetic Tests for Pouchitis

Anatomical Context for Pouchitis

MalaCards organs/tissues related to Pouchitis:

41
Colon, Liver, Small Intestine, Testes, Lung, Neutrophil, Prostate

Publications for Pouchitis

Articles related to Pouchitis:

(show top 50) (show all 1414)
# Title Authors PMID Year
1
Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease. 9 38
19079235 2008
2
Pouch-ouch. 9 38
18043236 2008
3
The assessment of a rapid noninvasive immunochromatographic assay test for fecal lactoferrin in patients with suspected inflammation of the ileal pouch. 9 38
18085334 2008
4
Pilot study on the effect of reducing dietary FODMAP intake on bowel function in patients without a colon. 9 38
17828776 2007
5
Differential expression of toll-like receptor 3 and 5 in ileal pouch mucosa of ulcerative colitis patients. 9 38
16770571 2007
6
The expression patterns of Toll-like receptors in the ileal pouch mucosa of postoperative ulcerative colitis patients. 9 38
16493544 2006
7
Combined carriership of TLR9-1237C and CD14-260T alleles enhances the risk of developing chronic relapsing pouchitis. 9 38
16437636 2005
8
Innate immune receptor genetic polymorphisms in pouchitis: is CARD15 a susceptibility factor? 9 38
16239841 2005
9
Fecal lactoferrin for diagnosis of symptomatic patients with ileal pouch-anal anastomosis. 9 38
15131788 2004
10
Biliary lactoferrin concentrations are increased in active inflammatory bowel disease: a factor in the pathogenesis of primary sclerosing cholangitis? 9 38
9791051 1998
11
Impact of paediatric onset primary sclerosing cholangitis on clinical course and outcome of inflammatory bowel disease: a case-control population-based study in Finland. 38
31402720 2019
12
Early Experience with Variant Two-Stage Approach in Surgical Management of Inflammatory Bowel Disease Colitis in the Pediatric Population. 38
31403384 2019
13
Long-term bowel function and fate of the ileal pouch after restorative proctocolectomy in patients with Crohn's disease. A systematic review with meta-analysis and metaregression. 38
31412119 2019
14
Efficacy of Vedolizumab for Refractory Pouchitis of the Ileo-anal Pouch: Results From a Multicenter US Cohort. 38
30810748 2019
15
Ulcerative Colitis and Crohn's Disease Have the Same Burden and Goals for Treatment. 38
31301452 2019
16
Prevention And Medical Treatment Of Pouchitis In Ulcerative Colitis. 38
31333137 2019
17
Current surgical practice in pediatric ulcerative colitis: A systematic review. 38
30241963 2019
18
Real-World Experience with Tofacitinib in IBD at a Tertiary Center. 38
30734234 2019
19
Complications after proctocolectomy and ileal pouch-anal anastomosis in pediatric patients: A systematic review. 38
30291026 2019
20
Pouchitis in pediatric ulcerative colitis: A multicenter study on behalf of Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition. 38
31324473 2019
21
The Structure and Function of the Human Small Intestinal Microbiota: Current Understanding and Future Directions. 38
31344510 2019
22
Identifying Outcomes in Clinical Trials of Pouchitis for the Development of a Core Outcome Set. 38
30268563 2019
23
Fecal Microbiota Transplantation in Pouchitis: Clinical, Endoscopic, Histologic, and Microbiota Results from a Pilot Study. 38
31302808 2019
24
Characterization of risk factors for floppy pouch complex in ulcerative colitis. 38
30972491 2019
25
Morbidity related to diverting ileostomy after restorative proctocolectomy in patients with ulcerative colitis. 38
30698869 2019
26
Predictors for Pouchitis After Ileal Pouch-Anal Anastomosis for Pediatric-Onset Ulcerative Colitis. 38
30743232 2019
27
Short- and Long-term Outcomes After Ileal Pouch Anal Anastomosis in Pediatric Patients: A Systematic Review. 38
30668719 2019
28
Ustekinumab Is Effective for the Treatment of Chronic Antibiotic-Refractory Pouchitis. 38
31187322 2019
29
De Novo Crohn Disease of the Pouch in Children Undergoing Ileal Pouch-Anal Anastomosis for Ulcerative Colitis. 38
31136563 2019
30
Does Age Affect Surgical Outcomes After Ileal Pouch-Anal Anastomosis in Children? 38
30710880 2019
31
Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis. 38
31136680 2019
32
Dual arterial blood supply D-pouch in a patient with ulcerative colitis undergoing proctocolectomy and ileal pouch-anal anastomosis: A case report. 38
31045791 2019
33
Fecal Proteases from Pouchitis Patients Activate Protease Activating Receptor-2 to Disrupt the Epithelial Barrier. 38
31056700 2019
34
Combined Endoscopic and Oral Fecal Microbiota Transplantation in Patients with Antibiotic-Dependent Pouchitis: Low Clinical Efficacy due to Low Donor Microbial Engraftment. 38
31172007 2019
35
Mucosa-Associated Microbiota in Ileoanal Pouches May Contribute to Clinical Symptoms, Particularly Stool Frequency, Independent of Endoscopic Disease Activity. 38
31117112 2019
36
The efficacy of fecal microbiota transplantation for patients with chronic pouchitis: A case series. 38
30997086 2019
37
How do you treat this diversion ileitis and pouchitis? 38
29588334 2019
38
Vedolizumab for chronic antibiotic-refractory pouchitis. 38
30976425 2019
39
Difference in the frequency of pouchitis between ulcerative colitis and familial adenomatous polyposis: is the explanation in peripouch fat? 38
30985958 2019
40
SATB2 and Hep Par 1 Immunohistochemistry Is Helpful in Distinguishing Between Inflamed and Architecturally Altered Ileal Pouch and Rectal Cuff Mucosa. 38
30192165 2019
41
The Effect of Biologics on Postoperative Complications in Children With Inflammatory Bowel Disease and Bowel Resection. 38
30247424 2019
42
Starch Consumption May Modify Antiglycan Antibodies and Fecal Fungal Composition in Patients With Ileo-Anal Pouch. 38
30535148 2019
43
The Effect of Smoking on the Risk of Pouchitis in Ulcerative Colitis Patients With Ileal Pouch-anal Anastomosis. 38
30124837 2019
44
Response to the Letter to the Editor from Dai et al, Regarding "Smoking and the Risk of Pouchitis in Ulcerative Colitis Patients with Ileal Pouch Anal Anastomosis". 38
30124832 2019
45
Comparable perioperative outcomes, long-term outcomes, and quality of life in a retrospective analysis of ulcerative colitis patients following 2-stage versus 3-stage proctocolectomy with ileal pouch-anal anastomosis. 38
30610435 2019
46
Factors Associated with Long-Term Quality of Life After Restorative Proctocolectomy with Ileal Pouch Anal Anastomosis. 38
30097964 2019
47
Ustekinumab Is Effective for the Treatment of Crohn's Disease of the Pouch in a Multicenter Cohort. 38
30295784 2019
48
Fruit consumption is associated with alterations in microbial composition and lower rates of pouchitis. 38
30828722 2019
49
Short-term Results After Totally Robotic Restorative Total Proctocolectomy With Ileal Pouch Anal Anastomosis for Ulcerative Colitis. 38
30768495 2019
50
Clinical Outcomes After Ileal Pouch-Anal Anastomosis in Pediatric Patients. 38
30527503 2019

Variations for Pouchitis

Expression for Pouchitis

Search GEO for disease gene expression data for Pouchitis.

Pathways for Pouchitis

GO Terms for Pouchitis

Biological processes related to Pouchitis according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.78 IL1RN IL10 CXCL8
2 immune response GO:0006955 9.73 TLR4 IL1RN IL10 CXCL8
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.67 TLR4 NOD2 LTF
4 defense response to Gram-negative bacterium GO:0050829 9.65 TLR4 LTF
5 neutrophil chemotaxis GO:0030593 9.65 IL1RN CXCL8
6 regulation of inflammatory response GO:0050727 9.65 TLR4 NOD2
7 response to glucocorticoid GO:0051384 9.64 IL1RN IL10
8 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.64 LTF CXCL8
9 positive regulation of tumor necrosis factor production GO:0032760 9.63 TLR4 NOD2
10 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.63 TLR4 NOD2
11 interleukin-1-mediated signaling pathway GO:0070498 9.62 NOD2 IL1RN
12 negative regulation of tumor necrosis factor production GO:0032720 9.62 TLR4 IL10
13 inflammatory response GO:0006954 9.62 TLR4 IL1RN IL10 CXCL8
14 positive regulation of interleukin-1 beta secretion GO:0050718 9.6 TLR4 NOD2
15 negative regulation of interleukin-6 production GO:0032715 9.59 TLR4 IL10
16 negative regulation of interferon-gamma production GO:0032689 9.58 TLR4 IL10
17 positive regulation of interleukin-8 production GO:0032757 9.58 TLR4 NOD2
18 positive regulation of interleukin-10 production GO:0032733 9.57 TLR4 NOD2
19 leukocyte chemotaxis GO:0030595 9.56 IL10 CXCL8
20 positive regulation of stress-activated MAPK cascade GO:0032874 9.55 TLR4 NOD2
21 positive regulation of macrophage activation GO:0043032 9.54 TLR4 IL10
22 positive regulation of JNK cascade GO:0046330 9.54 TLR4 NOD2 IL1RN
23 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.52 TLR4 NOD2
24 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.51 TLR4 NOD2
25 response to molecule of bacterial origin GO:0002237 9.48 IL10 CXCL8
26 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.46 IL1RN IL10
27 defense response to bacterium GO:0042742 9.46 TLR4 NOD2 LTF IL10
28 positive regulation of interleukin-6 production GO:0032755 9.43 TLR4 NOD2 IL1RN
29 positive regulation of MHC class II biosynthetic process GO:0045348 9.4 TLR4 IL10
30 response to activity GO:0014823 9.31 IL10
31 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.26 TLR4 NOD2 LTF IL1RN
32 cellular response to lipopolysaccharide GO:0071222 9.02 TLR4 NOD2 IL1RN IL10 CXCL8

Molecular functions related to Pouchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.96 TLR4 LTF
2 cytokine activity GO:0005125 8.8 IL1RN IL10 CXCL8

Sources for Pouchitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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