Powassan Encephalitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PWS001 MIFTS: 25	Powassan Encephalitis Categories: Infectious diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

Sources

Aliases & Classifications for Powassan Encephalitis

MalaCards integrated aliases for Powassan Encephalitis:

Name: Powassan Encephalitis ¹² ¹⁵ ⁷¹

Powassan Encephalitis Virus Infection ⁷¹

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050179

UMLS ⁷¹ C0032858 C1563215

Sources

Summaries for Powassan Encephalitis

Disease Ontology : ¹² A viral infectious disease that results in inflammation located in brain, has material basis in Powassan virus, which is transmitted by Ixodes and transmitted by Dermacentor species of ticks. The infection has symptom headache, has symptom fever, has symptom vomiting, has symptom stiff neck, has symptom sleepiness, has symptom breathing distress, has symptom tremors, has symptom confusion, has symptom seizures, has symptom paralysis, and has symptom coma.

MalaCards based summary : Powassan Encephalitis, also known as powassan encephalitis virus infection, is related to colorado tick fever and encephalitis, and has symptoms including seizures, vomiting and fever. An important gene associated with Powassan Encephalitis is RRP8 (Ribosomal RNA Processing 8), and among its related pathways/superpathways is Collagen chain trimerization. Affiliated tissues include brain, eye and salivary gland.

Sources

Related Diseases for Powassan Encephalitis

Diseases related to Powassan Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)

#	Related Disease	Score	Top Affiliating Genes
1	colorado tick fever	29.2	TLL2 MEP1B ASTL
2	encephalitis	10.7
3	tick-borne encephalitis	10.4
4	kearns-sayre syndrome	10.3
5	west nile virus	10.1
6	follicular lymphoma	10.1
7	mumps	10.1
8	lyme disease	10.1
9	orchitis	10.1
10	viral encephalitis	10.1
11	viral infectious disease	10.1
12	limbic encephalitis	10.1
13	omsk hemorrhagic fever	9.6	TLL2 ASTL
14	louping ill	8.8	TLL2 MEP1B MEP1A ASTL

Graphical network of the top 20 diseases related to Powassan Encephalitis:

Sources

Symptoms & Phenotypes for Powassan Encephalitis

Symptoms:

¹² (show all 11)

• seizures
• vomiting
• fever
• headache
• paralysis
• confusion

• coma
• stiff neck
• sleepiness
• breathing distress
• tremors

Sources

Drugs & Therapeutics for Powassan Encephalitis

Search Clinical Trials , NIH Clinical Center for Powassan Encephalitis

Sources

Genetic Tests for Powassan Encephalitis

Sources

Anatomical Context for Powassan Encephalitis

The Foundational Model of Anatomy Ontology organs/tissues related to Powassan Encephalitis:

¹⁹

Brain

MalaCards organs/tissues related to Powassan Encephalitis:

⁴⁰

Brain, Eye, Salivary Gland

Sources

Publications for Powassan Encephalitis

Articles related to Powassan Encephalitis:

(show all 31)

#	Title	Authors	PMID	Year
1	Prevalence of Infection and Co-Infection and Presence of Rickettsial Endosymbionts in Ixodes Scapularis (Acari: Ixodidae) in Connecticut, USA. ⁶¹	Pokutnaya D...Diaz AJ	31971489	2020
2	Seroprevalence of Borrelia burgdorferi, B. miyamotoi, and Powassan Virus in Residents Bitten by Ixodes Ticks, Maine, USA. ⁶¹	Smith RP...Krause PJ	30882312	2019
3	A case of Powassan encephalitis acquired in southern Quebec. ⁶¹	Sanderson M...Morshed M	30559280	2018
4	Tick⁻Virus⁻Host Interactions at the Cutaneous Interface: The Nidus of Flavivirus Transmission. ⁶¹	Hermance ME...Thangamani S	29986483	2018
5	Fatal Powassan Encephalitis (Deer Tick Virus, Lineage II) in a Patient With Fever and Orchitis Receiving Rituximab. ⁶¹	Solomon IH...De Girolami U	29554185	2018
6	First confirmed case of Powassan neuroinvasive disease in Rhode Island. ⁶¹	Patel KM...Reece RM	29942757	2018
7	The eye and tick-borne disease in the United States. ⁶¹	Sathiamoorthi S...Smith WM	27585218	2016
8	Interaction of Flaviviruses with Reproduction Inhibitors Binding in β-OG Pocket: Insights from Molecular Dynamics Simulations. ⁶¹	Dueva EV...Zefirov NS	27485304	2014
9	The prevalence of zoonotic tick-borne pathogens in Ixodes scapularis collected in the Hudson Valley, New York State. ⁶¹	Aliota MT...Kramer LD	24689680	2014
10	Potential role of deer tick virus in Powassan encephalitis cases in Lyme disease-endemic areas of New York, U.S.A. ⁶¹	El Khoury MY...Wong SJ	24274334	2013
11	Changing epidemiology of Powassan encephalitis in North America suggests the emergence of the deer tick virus subtype. ⁶¹	Ei Khoury MY...Wormser GP	24124795	2013
12	Early immunologic events at the tick-host interface. ⁶¹	Heinze DM...Thangamani S	23077588	2012
13	Supranuclear ophthalmoplegia in Powassan encephalitis. ⁶¹	Trepanier P...Savard M	20929710	2010
14	Tick (Acari: Ixodidae) infestation at two rural, seasonal camps in Maine and Vermont. ⁶¹	Lubelczyk C...Smith RP	19925041	2010
15	Zoonotic tick-borne flaviviruses. ⁶¹	Dobler G	19765917	2010
16	Increased recognition of Powassan encephalitis in the United States, 1999-2005. ⁶¹	Hinten SR...Marfin AA	18959500	2008
17	Powassan encephalitis and Colorado tick fever. ⁶¹	Romero JR...Simonsen KA	18755390	2008
18	Transcriptome analysis of the salivary glands of Dermacentor andersoni Stiles (Acari: Ixodidae). ⁶¹	Alarcon-Chaidez FJ...Wikel SK	17175446	2007
19	Tick-borne encephalopathies : epidemiology, diagnosis, treatment and prevention. ⁶¹	Gunther G...Haglund M	16332143	2005
20	Ophthalmoplegia in Powassan encephalitis. ⁶¹	Lessell S...Collins TE	12771287	2003
21	From the Centers for Disease Control and Prevention. Outbreak of Powassan encephalitis--Maine and Vermont, 1999-2001. ⁶¹		11693145	2001
22	Outbreak of Powassan encephalitis--Maine and Vermont, 1999-2001. ⁶¹	Centers for Disease Control and Prevention (CDC)	11787585	2001
23	Powassan encephalitis. ⁶¹	Ralph ED	10906898	1999
24	Powassan encephalitis: a case report with neuropathology and literature review. ⁶¹	Gholam BI...Provias JP	10906899	1999
25	Arboviral disease--United States, 1994. ⁶¹	Centers for Disease Control and Prevention (CDC)	7643850	1995
26	Diversity of tick species biting humans in an emerging area for Lyme disease. ⁶¹	Smith RP...Dearborn R	1536337	1992
27	[The clinico-epidemiological characteristics of Powassan encephalitis in the southern Soviet Far East]. ⁶¹	Leonova GN...Krugliak SP	1651637	1991
28	Powassan encephalitis in new brunswick. ⁶¹	Fitch WM...Artsob H	21233909	1990
29	[Tick-borne encephalitis in the Maritime Territory]. ⁶¹	Leonov GN...Somov GP	2816183	1989
30	[The role of wild murine rodents in the selection of different strains of tick-borne encephalitis and Powassan viruses]. ⁶¹	Leonova GN...Rybachuk VN	2829440	1987
31	Arbovirus infections in man in British Columbia. ⁶¹	Kettyls GD...Rublee JD	5034698	1972

Sources

Genes for Powassan Encephalitis

Genes related to Powassan Encephalitis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	RRP8	Ribosomal RNA Processing 8	Protein Coding	6.03	DISEASES inferred ¹⁵
2	NCBP3	Nuclear Cap Binding Subunit 3	Protein Coding	5.69	DISEASES inferred ¹⁵
3	LINC01150	Long Intergenic Non-Protein Coding RNA 1150	RNA Gene	4.96	DISEASES inferred ¹⁵
4	TLL2	Tolloid Like 2	Protein Coding	4.93	DISEASES inferred ¹⁵
5	ASTL	Astacin Like Metalloendopeptidase	Protein Coding	4.89	DISEASES inferred ¹⁵
6	MEP1B	Meprin A Subunit Beta	Protein Coding	4.85	DISEASES inferred ¹⁵
7	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	4.82	DISEASES inferred ¹⁵
8	MEP1A	Meprin A Subunit Alpha	Protein Coding	4.81	DISEASES inferred ¹⁵
9	TSKU	Tsukushi, Small Leucine Rich Proteoglycan	Protein Coding	4.74	DISEASES inferred ¹⁵

Sources

Variations for Powassan Encephalitis

Sources

Expression for Powassan Encephalitis

Search GEO for disease gene expression data for Powassan Encephalitis.

Sources

Pathways for Powassan Encephalitis

Pathways related to Powassan Encephalitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Collagen chain trimerization ⁶⁵ Show member pathways Anchoring fibril formation ⁶⁵ Assembly of collagen fibrils and other multimeric structures ⁶⁵ Blood Coagulation Cascade ⁶³ Collagen biosynthesis and modifying enzymes ⁶⁵ Collagen formation ⁶⁵ Crosslinking of collagen fibrils ⁶⁵ Intrinsic Prothrombin Activation Pathway ⁶³ Protein digestion and absorption ³⁶	11.53	TLL2 MEP1B MEP1A

Sources

GO Terms for Powassan Encephalitis

Cellular components related to Powassan Encephalitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	meprin A complex	GO:0017090	8.62	MEP1B MEP1A

Biological processes related to Powassan Encephalitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	proteolysis	GO:0006508	8.92	TLL2 MEP1B MEP1A ASTL

Molecular functions related to Powassan Encephalitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	zinc ion binding	GO:0008270	9.56	TLL2 MEP1B MEP1A ASTL
2	peptidase activity	GO:0008233	9.46	TLL2 MEP1B MEP1A ASTL
3	metallopeptidase activity	GO:0008237	9.26	TLL2 MEP1B MEP1A ASTL
4	metalloendopeptidase activity	GO:0004222	8.92	TLL2 MEP1B MEP1A ASTL

Sources

Sources for Powassan Encephalitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia