Aliases & Classifications for Powassan Encephalitis

MalaCards integrated aliases for Powassan Encephalitis:

Name: Powassan Encephalitis 12 15 73
Powassan Encephalitis Virus Infection 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050179

Summaries for Powassan Encephalitis

Disease Ontology : 12 A viral infectious disease that results in inflammation located in brain, has material basis in Powassan virus, which is transmitted by Ixodes and transmitted by Dermacentor species of ticks. The infection has symptom headache, has symptom fever, has symptom vomiting, has symptom stiff neck, has symptom sleepiness, has symptom breathing distress, has symptom tremors, has symptom confusion, has symptom seizures, has symptom paralysis, and has symptom coma.

MalaCards based summary : Powassan Encephalitis, also known as powassan encephalitis virus infection, is related to encephalitis and lyme disease, and has symptoms including headache, fever and vomiting. An important gene associated with Powassan Encephalitis is GAD2 (Glutamate Decarboxylase 2), and among its related pathways/superpathways is Allograft rejection. Affiliated tissues include brain and brain, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Powassan encephalitis, caused by the Powassan virus (POWV), a flavivirus also known as the deer tick... more...

Related Diseases for Powassan Encephalitis

Diseases related to Powassan Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 encephalitis 10.5
2 lyme disease 9.9
3 orchitis 9.9
4 colorado tick fever 9.9
5 autoimmune disease 9.0 CD40LG GAD2

Graphical network of the top 20 diseases related to Powassan Encephalitis:



Diseases related to Powassan Encephalitis

Symptoms & Phenotypes for Powassan Encephalitis

Symptoms:

12 (show all 11)
  • headache
  • fever
  • vomiting
  • stiff neck
  • sleepiness
  • breathing distress
  • tremors
  • confusion
  • seizures
  • paralysis
  • coma

GenomeRNAi Phenotypes related to Powassan Encephalitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.23 CD40LG GAD2
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.23 CD40LG GAD2

Drugs & Therapeutics for Powassan Encephalitis

Search Clinical Trials , NIH Clinical Center for Powassan Encephalitis

Genetic Tests for Powassan Encephalitis

Anatomical Context for Powassan Encephalitis

The Foundational Model of Anatomy Ontology organs/tissues related to Powassan Encephalitis:

19
Brain

MalaCards organs/tissues related to Powassan Encephalitis:

41
Brain

Publications for Powassan Encephalitis

Articles related to Powassan Encephalitis:

(show all 12)
# Title Authors Year
1
Fatal Powassan Encephalitis (Deer Tick Virus, Lineage II) in a Patient With Fever and Orchitis Receiving Rituximab. ( 29554185 )
2018
2
Potential role of deer tick virus in Powassan encephalitis cases in Lyme disease-endemic areas of New York, U.S.A. ( 24274334 )
2013
3
Changing epidemiology of Powassan encephalitis in North America suggests the emergence of the deer tick virus subtype. ( 24124795 )
2013
4
Supranuclear ophthalmoplegia in Powassan encephalitis. ( 20929710 )
2010
5
Increased recognition of Powassan encephalitis in the United States, 1999-2005. ( 18959500 )
2008
6
Powassan encephalitis and Colorado tick fever. ( 18755390 )
2008
7
Ophthalmoplegia in Powassan encephalitis. ( 12771287 )
2003
8
Outbreak of Powassan encephalitis--Maine and Vermont, 1999-2001. ( 11787585 )
2001
9
From the Centers for Disease Control and Prevention. Outbreak of Powassan encephalitis--Maine and Vermont, 1999-2001. ( 11693145 )
2001
10
Powassan encephalitis: a case report with neuropathology and literature review. ( 10906899 )
1999
11
Powassan encephalitis. ( 10906898 )
1999
12
Powassan encephalitis in new brunswick. ( 21233909 )
1990

Variations for Powassan Encephalitis

Expression for Powassan Encephalitis

Search GEO for disease gene expression data for Powassan Encephalitis.

Pathways for Powassan Encephalitis

Pathways related to Powassan Encephalitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.36 CD40LG GAD2

GO Terms for Powassan Encephalitis

Sources for Powassan Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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