MCID: PRN062
MIFTS: 9

Pr Interval, Variation in

Aliases & Classifications for Pr Interval, Variation in

MalaCards integrated aliases for Pr Interval, Variation in:

Name: Pr Interval, Variation in 56
Atrioventricular Conduction Time, Variation in 56

Characteristics:

OMIM:

56
Inheritance:
? polygenic influence


External Ids:

OMIM 56 108980

Summaries for Pr Interval, Variation in

OMIM : 56 The PR (or PQ) interval is the time required for an electrical impulse to travel from the atrial myocardium adjacent to the sinus node through the atrioventricular node (AVN) to the Purkinje fibers. Delayed conduction results in prolongation of the PR interval and subsequent risk of atrial fibrillation (summary by Holm et al., 2010). The PR interval has a substantial heritable component, with heritability estimates ranging between 30 and 50%. The PR interval is considered an intermediate phenotype for atrial fibrillation, as alterations in atrial action potential duration and in atrioventricular conduction influence both PR interval and atrial fibrillation risk (summary by Pfeufer et al., 2010). (108980)

MalaCards based summary : Pr Interval, Variation in, is also known as atrioventricular conduction time, variation in. Affiliated tissues include atrioventricular node and heart.

Related Diseases for Pr Interval, Variation in

Symptoms & Phenotypes for Pr Interval, Variation in

Symptoms via clinical synopsis from OMIM:

56
Lab:
electrocardiographic atrioventricular conduction time

Clinical features from OMIM:

108980

Drugs & Therapeutics for Pr Interval, Variation in

Search Clinical Trials , NIH Clinical Center for Pr Interval, Variation in

Genetic Tests for Pr Interval, Variation in

Anatomical Context for Pr Interval, Variation in

MalaCards organs/tissues related to Pr Interval, Variation in:

40
Atrioventricular Node, Heart

Publications for Pr Interval, Variation in

Articles related to Pr Interval, Variation in:

# Title Authors PMID Year
1
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. 56
21076409 2010
2
Genome-wide association study of PR interval. 56
20062060 2010
3
Genetic variation in SCN10A influences cardiac conduction. 56
20062061 2010
4
Several common variants modulate heart rate, PR interval and QRS duration. 56
20062063 2010
5
Inheritance of atrioventricular conduction time in Tokelau Islanders. 56
3948429 1986
6
The atrioventricular conduction time - a heritable trait? III. Twin studies. 56
7201363 1982
7
Atrioventricular conduction time--a heritable trait? 56
7449186 1980
8
Variability of heart rate, P-R, QRS and Q-T durations in twins. 56
7188949 1980

Variations for Pr Interval, Variation in

Expression for Pr Interval, Variation in

Search GEO for disease gene expression data for Pr Interval, Variation in.

Pathways for Pr Interval, Variation in

GO Terms for Pr Interval, Variation in

Sources for Pr Interval, Variation in

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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