PDCD
MCID: PRD026
MIFTS: 20

Pre-Descemet Corneal Dystrophy (PDCD)

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Pre-Descemet Corneal Dystrophy

MalaCards integrated aliases for Pre-Descemet Corneal Dystrophy:

Name: Pre-Descemet Corneal Dystrophy 58
Pdcd 58

Characteristics:

Orphanet epidemiological data:

58
pre-descemet corneal dystrophy
Prevalence: <1/1000000 (Worldwide); Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 58  
Rare eye diseases


External Ids:

ICD10 via Orphanet 33 H18.5
UMLS via Orphanet 71 C0339282
Orphanet 58 ORPHA293462

Summaries for Pre-Descemet Corneal Dystrophy

MalaCards based summary : Pre-Descemet Corneal Dystrophy, also known as pdcd, is related to pyruvate dehydrogenase e1-alpha deficiency and corneal dystrophy. An important gene associated with Pre-Descemet Corneal Dystrophy is PRDX3 (Peroxiredoxin 3). Affiliated tissues include eye, prostate and t cells, and related phenotype is Negative genetic interaction between MUS81-/- and MUS81+/+.

Related Diseases for Pre-Descemet Corneal Dystrophy

Diseases related to Pre-Descemet Corneal Dystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 pyruvate dehydrogenase e1-alpha deficiency 11.1
2 corneal dystrophy 10.6
3 ichthyosis, x-linked 10.4
4 ichthyosis 10.4
5 stromal dystrophy 10.2
6 keratopathy 10.2
7 rheumatoid arthritis 10.0
8 aortic aneurysm, familial abdominal, 1 9.9
9 spondyloarthropathy 1 9.9
10 breast cancer 9.9
11 spastic paraplegia, intellectual disability, nystagmus, and obesity 9.9
12 polycystic ovary syndrome 9.9
13 inflammatory spondylopathy 9.9
14 larynx cancer 9.9
15 aortic aneurysm 9.9
16 spondylitis 9.9
17 arthritis 9.9
18 aneurysm 9.9

Graphical network of the top 20 diseases related to Pre-Descemet Corneal Dystrophy:



Diseases related to Pre-Descemet Corneal Dystrophy

Symptoms & Phenotypes for Pre-Descemet Corneal Dystrophy

GenomeRNAi Phenotypes related to Pre-Descemet Corneal Dystrophy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between MUS81-/- and MUS81+/+ GR00255-A-2 8.62 PRDX3 STS

Drugs & Therapeutics for Pre-Descemet Corneal Dystrophy

Search Clinical Trials , NIH Clinical Center for Pre-Descemet Corneal Dystrophy

Genetic Tests for Pre-Descemet Corneal Dystrophy

Anatomical Context for Pre-Descemet Corneal Dystrophy

MalaCards organs/tissues related to Pre-Descemet Corneal Dystrophy:

40
Eye, Prostate, T Cells, Endothelial, Tongue

Publications for Pre-Descemet Corneal Dystrophy

Articles related to Pre-Descemet Corneal Dystrophy:

(show top 50) (show all 100)
# Title Authors PMID Year
1
Dexmedetomidine suppresses the development of abdominal aortic aneurysm by downregulating the mircoRNA‑21/PDCD 4 axis. 61
33786608 2021
2
Anesthesia management for ENT surgery in a child with X-linked pyruvate kinase deficiency. 61
33295086 2021
3
Significance of in vitro photodynamic cytodiagnosis using 5-aminolevulinic acid in solid pancreatic tumors extracted by endoscopic ultrasound-guided fine-needle aspiration. 61
31629090 2021
4
Emotional and behavioral problems in Japanese preschool children with motor coordination difficulties: the role of autistic traits. 61
33566188 2021
5
Ferroptosis-Related Long Non-Coding RNA signature predicts the prognosis of Head and neck squamous cell carcinoma. 61
33767582 2021
6
Multimodal Imaging of Pre-Descemet Corneal Dystrophy Associated With X-Linked Ichthyosis and Deletion of the STS Gene. 61
32482962 2020
7
Utility of specific amino acid ratios in screening for pyruvate dehydrogenase complex deficiencies and other mitochondrial disorders associated with congenital lactic acidosis and newborn screening prospects. 61
33204598 2020
8
Multimodal imaging of pre-Descemet corneal dystrophy. 61
31298040 2020
9
Should We Be Utilizing More Liver Grafts From Pediatric Donation After Circulatory Death Donors? A National Analysis of the SRTR from 2002-2017. 61
32947583 2020
10
Patterns of Choroidal Deepening in Highly Myopic Eyes with Dome-Shaped Macula. 61
31868019 2020
11
MicroRNA-16, Programmed Cell Death Protein-4 (PDCD-4) and Polycystic Ovarian Syndrome. 61
32893806 2020
12
The daily practice reality of PD-L1 (CD274) evaluation in non-small cell lung cancer: A retrospective study. 61
32269612 2020
13
Punctiform and Polychromatic Pre-Descemet Corneal Dystrophy: Clinical Evaluation and Identification of the Genetic Basis. 61
31782998 2020
14
Psychometric Validation and Reference Norms for the European Spanish Developmental Coordination Disorder Questionnaire: DCDQ-ES. 61
32252448 2020
15
Self-perceptions in children with probable developmental coordination disorder with and without overweight. 61
32045831 2020
16
On-Demand, Ultraselective Hydrogenation System Enabled by Precisely Modulated Pd-Cd Nanocubes. 61
31852179 2020
17
Sinomenine restrains breast cancer cells proliferation, migration and invasion via modulation of miR-29/PDCD-4 axis. 61
31556312 2019
18
Physical activity in young children at risk for developmental coordination disorder. 61
30963540 2019
19
Hypermobility, developmental coordination disorder and physical activity in an Irish paediatric population. 61
31062457 2019
20
Role of Programmed Cell Death 4 (PDCD4)-Mediated Akt Signaling Pathway in Vascular Endothelial Cell Injury Caused by Lower-Extremity Ischemia-Reperfusion in Rats. 61
31253757 2019
21
Development of a multinational registry of pediatric deceased organ donation activity. 61
30724003 2019
22
Adults with probable developmental coordination disorder selectively process early visual, but not tactile information during action preparation. An electrophysiological study. 61
30981450 2019
23
Pyruvate Dehydrogenase Complex Deficiency: An Unusual Cause of Recurrent Lactic Acidosis in a Paediatric Critical Care Unit. 61
31161145 2019
24
Pediatric donation after circulatory determination of death (pDCD): A narrative review. 61
29716830 2019
25
The Possible Role of PD-1 Protein in Ganoderma lucidum-Mediated Immunomodulation and Cancer Treatment. 61
31595795 2019
26
The Molecular Evolution and Functional Divergence of Lamprey Programmed Cell Death Genes. 61
31281315 2019
27
Motor learning in children with developmental coordination disorder: The role of focus of attention and working memory. 61
30419514 2018
28
Heredity and in vivo confocal microscopy of punctiform and polychromatic pre-Descemet dystrophy. 61
29728753 2018
29
Neuron-specific knockdown of Drosophila PDHB induces reduction of lifespan, deficient locomotive ability, abnormal morphology of motor neuron terminals and photoreceptor axon targeting. 61
29501567 2018
30
Aquaporin-4-autoimmunity in patients with systemic lupus erythematosus: A predominantly population-based study. 61
28326889 2018
31
[Optical coherence tomography and in vivo confocal microscopy in pre-descemet corneal dystrophy]. 61
29422275 2018
32
The path to paediatric donation after circulatory determination of death guidelines. 61
29479276 2018
33
Deficits in Visuo-Motor Temporal Integration Impacts Manual Dexterity in Probable Developmental Coordination Disorder. 61
29556211 2018
34
PDCD5 regulates cell proliferation, cell cycle progression and apoptosis. 61
29403562 2018
35
Moderating Effects of Physical Activity and Global Self-Worth on Internalizing Problems in School-Aged Children With Developmental Coordination Disorder. 61
30283385 2018
36
Intermetallic: A Pseudoelement for Catalysis. 61
29219300 2017
37
Peri-dome Choroidal Deepening in Highly Myopic Eyes With Dome-Shaped Maculas. 61
28911990 2017
38
Maintenance of PD-1 on brain-resident memory CD8 T cells is antigen independent. 61
28829048 2017
39
Diminished motor imagery capability in adults with motor impairment: An fMRI mental rotation study. 61
28673767 2017
40
Poor Imitative Performance of Unlearned Gestures in Children with Probable Developmental Coordination Disorder. 61
27726691 2017
41
Tracking cardiorespiratory fitness and physical activity in children with and without motor coordination problems. 61
27760715 2017
42
In vivo confocal microscopy of pre-Descemet corneal dystrophy associated with X-linked ichthyosis: a case report. 61
28302098 2017
43
Case-control Association Study of Autoimmunity Associated Variants in PDCD1 and Juvenile Idiopathic Arthritis. 61
28056736 2017
44
White matter alterations in adults with probable developmental coordination disorder: an MRI diffusion tensor imaging study. 61
27902527 2017
45
The association between polymorphisms in the PDCD1 gene and the risk of cancer: A PRISMA-compliant meta-analysis. 61
27749524 2016
46
The Association Between Viral Infections and Co-stimulatory Gene Polymorphisms in Kidney Transplant Outcomes. 61
27800130 2016
47
Longitudinal examination of objectively-measured physical activity and sedentary time among children with and without significant movement impairments. 61
26999034 2016
48
PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6/STAT3 Pathway in Mice. 61
26891257 2016
49
Exploration of the regulatory effect of miR-21 on breast cancer cell line proliferation and invasion as well as the downstream target genes. 61
27261856 2016
50
MicroRNA-206, let-7a and microRNA-21 pathways involved in the anti-angiogenesis effects of the interval exercise training and hormone therapy in breast cancer. 61
26924493 2016

Variations for Pre-Descemet Corneal Dystrophy

Expression for Pre-Descemet Corneal Dystrophy

Search GEO for disease gene expression data for Pre-Descemet Corneal Dystrophy.

Pathways for Pre-Descemet Corneal Dystrophy

GO Terms for Pre-Descemet Corneal Dystrophy

Cellular components related to Pre-Descemet Corneal Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome GO:0005768 8.62 STS PRDX3

Sources for Pre-Descemet Corneal Dystrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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