MCID: PRM023
MIFTS: 33

Pre-Malignant Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Pre-Malignant Neoplasm

MalaCards integrated aliases for Pre-Malignant Neoplasm:

Name: Pre-Malignant Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060071

Summaries for Pre-Malignant Neoplasm

Disease Ontology : 12 A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer.

MalaCards based summary : Pre-Malignant Neoplasm is related to conjunctival intraepithelial neoplasm and scirrhous adenocarcinoma. An important gene associated with Pre-Malignant Neoplasm is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are GPCR Pathway and Circadian entrainment. Related phenotypes are Decreased viability in esophageal squamous lineage and Increased cell death HMECs cells

Related Diseases for Pre-Malignant Neoplasm

Diseases in the Lip Cancer family:

Pre-Malignant Neoplasm Lip Carcinoma in Situ
in Situ Carcinoma Eye Carcinoma in Situ

Diseases related to Pre-Malignant Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 213)
# Related Disease Score Top Affiliating Genes
1 conjunctival intraepithelial neoplasm 11.1
2 scirrhous adenocarcinoma 11.1 ERBB2 PGR
3 breast apocrine carcinoma 11.1 ERBB2 PGR
4 endometrium carcinoma in situ 11.0 PGR TP53
5 breast intraductal proliferative lesion 11.0 EGFR ERBB2
6 vulvar syringoma 11.0 ESR1 PGR
7 lung leiomyoma 11.0 ESR1 PGR
8 endometrial clear cell adenocarcinoma 11.0 ESR1 TP53
9 brain ependymoma 11.0 EGFR TP53
10 vulvar benign neoplasm 11.0 ESR1 PGR
11 trigonitis 11.0 ESR1 PGR
12 breast mucoepidermoid carcinoma 11.0 ERBB2 PGR
13 brain stem astrocytic neoplasm 10.9 CDKN2A TP53
14 vulvar leiomyoma 10.9 ESR1 PGR
15 glassy cell carcinoma of the cervix 10.9 ERBB2 ESR1 PGR
16 gallbladder squamous cell carcinoma 10.9 ERBB2 TP53
17 gastric papillary adenocarcinoma 10.9 ERBB2 TP53
18 vestibular gland benign neoplasm 10.9 ESR1 PGR TP53
19 bartholin's gland adenoma 10.9 ESR1 PGR TP53
20 progesterone-receptor positive breast cancer 10.9 ERBB2 ESR1 PGR
21 breast metaplastic carcinoma 10.9 ERBB2 KRT5 PGR
22 uterine body mixed cancer 10.9 ERBB2 PGR TP53
23 intracystic papillary adenoma 10.9 EGFR ERBB2 PGR
24 progesterone-receptor negative breast cancer 10.9 EGFR ERBB2 PGR
25 inverted transitional papilloma 10.9 CDKN2A KRT5
26 cervical carcinosarcoma 10.9 ESR1 PGR TP53
27 vulvar dystrophy 10.9 CDKN2A PGR
28 adenosarcoma 10.9 ESR1 PGR TP53
29 hereditary site-specific ovarian cancer syndrome 10.8 BRCA1 BRCA2
30 breast cystic hypersecretory carcinoma 10.8 CDH1 ERBB2 KRT5
31 breast secretory carcinoma 10.8 ERBB2 KRT5 PGR
32 esophageal adenosquamous carcinoma 10.8 CDH1 KRT5
33 endometrial mucinous adenocarcinoma 10.8 CDKN2A ESR1 PGR
34 adenoid basal cell carcinoma 10.8 CDKN2A ESR1 PGR
35 serous cystadenocarcinoma 10.8 ERBB2 PGR TP53
36 vulvar intraepithelial neoplasia 10.8 CDH1 KRT5 TP53
37 epidermolysis bullosa simplex, autosomal recessive 1 10.8 KRT14 KRT5
38 keratinizing squamous cell carcinoma 10.8 CDKN2A KRT5 TP53
39 barrett's adenocarcinoma 10.8 CDKN2A ERBB2 TP53
40 cystadenocarcinoma 10.8 ERBB2 PGR TP53
41 schneiderian carcinoma 10.8 CDKN2A KRT5 TP53
42 papillary serous adenocarcinoma 10.8 BRCA1 PGR TP53
43 comedo carcinoma 10.8 ERBB2 ESR1
44 cerebral convexity meningioma 10.8 CDH1 TP53
45 necrotizing sialometaplasia 10.8 CDKN2A KRT5 TP53
46 oropharynx cancer 10.8 CDKN2A EGFR TP53
47 optic nerve neoplasm 10.8 CDKN2A KRT5 TP53
48 malignant spiradenoma 10.8 KRT5 TP53
49 spindle cell carcinoma 10.8 CDH1 KRT5 PGR
50 ovarian serous cystadenocarcinoma 10.7 ERBB2 PGR TP53

Graphical network of the top 20 diseases related to Pre-Malignant Neoplasm:



Diseases related to Pre-Malignant Neoplasm

Symptoms & Phenotypes for Pre-Malignant Neoplasm

GenomeRNAi Phenotypes related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.7 BRCA1 BRCA2 CCND1 CDH1 CDKN2A ERBB2
2 Increased cell death HMECs cells GR00103-A-0 9.1 BRCA1 EGFR PGR PIP S100A7 TP53

MGI Mouse Phenotypes related to Pre-Malignant Neoplasm:

46 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.52 SERPIND1 TP53 BRCA2 ANXA8L1 BRCA1 CCND1
2 digestive/alimentary MP:0005381 10.45 TP53 BRCA2 BRCA1 CCND1 ERBB2 CDH1
3 growth/size/body region MP:0005378 10.42 PPP3R1 TP53 BRCA2 BRCA1 CCND1 CDKN2A
4 cardiovascular system MP:0005385 10.41 PPP3R1 SERPIND1 TP53 BRCA1 CCND1 CDH1
5 endocrine/exocrine gland MP:0005379 10.4 PPP3R1 TP53 BRCA2 BRCA1 CCND1 CDH1
6 homeostasis/metabolism MP:0005376 10.4 TP53 PPP3R1 SERPIND1 CCND1 BRCA2 BRCA1
7 mortality/aging MP:0010768 10.39 PPP3R1 SERPIND1 TP53 BRCA2 BRCA1 CCND1
8 hematopoietic system MP:0005397 10.38 PPP3R1 SERPIND1 TP53 BRCA2 ANXA8L1 BRCA1
9 immune system MP:0005387 10.36 TP53 PPP3R1 ANXA8L1 BRCA2 BRCA1 CCND1
10 behavior/neurological MP:0005386 10.35 TP53 PPP3R1 BRCA1 CCND1 BRCA2 CDKN2A
11 integument MP:0010771 10.34 TP53 BRCA2 BRCA1 CCND1 CDH1 EGFR
12 embryo MP:0005380 10.27 TP53 PPP3R1 BRCA2 BRCA1 CDKN2A CDH1
13 craniofacial MP:0005382 10.19 TP53 CCND1 EGFR ERBB2 INSM1 KRT14
14 neoplasm MP:0002006 10.14 TP53 BRCA2 BRCA1 CCND1 CDH1 EGFR
15 muscle MP:0005369 10.09 TP53 SERPIND1 BRCA1 CDKN2A EGFR ESR1
16 limbs/digits/tail MP:0005371 10.08 TP53 BRCA2 BRCA1 EGFR ESR1 ERBB2
17 no phenotypic analysis MP:0003012 10.02 TP53 CDKN2A CDH1 EGFR ESR1 INSM1
18 normal MP:0002873 9.97 TP53 CCND1 BRCA2 BRCA1 EGFR CDH1
19 reproductive system MP:0005389 9.93 TP53 BRCA2 BRCA1 CCND1 CDKN2A CDH1
20 pigmentation MP:0001186 9.73 TP53 BRCA1 EGFR CDKN2A KRT14 KRT17
21 respiratory system MP:0005388 9.65 TP53 CCND1 BRCA1 CDKN2A EGFR KRT14
22 skeleton MP:0005390 9.32 TP53 CCND1 BRCA2 BRCA1 EGFR CDKN2A

Drugs & Therapeutics for Pre-Malignant Neoplasm

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 EUS-guided Fine Needle Biopsy With a New Core Histology Needle Versus Conventional Fine Needle Aspiration Completed NCT01774162 Not Applicable

Search NIH Clinical Center for Pre-Malignant Neoplasm

Genetic Tests for Pre-Malignant Neoplasm

Anatomical Context for Pre-Malignant Neoplasm

Publications for Pre-Malignant Neoplasm

Variations for Pre-Malignant Neoplasm

Expression for Pre-Malignant Neoplasm

Search GEO for disease gene expression data for Pre-Malignant Neoplasm.

Pathways for Pre-Malignant Neoplasm

Pathways related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 BRCA1 BRCA2 CCND1 CDKN2A EGFR ERBB2
2
Show member pathways
12.97 EGFR ESR1 KRT14 KRT17 PGR PPP3R1
3
Show member pathways
12.72 BRCA2 CCND1 CDH1 CDKN2A EGFR ERBB2
4
Show member pathways
12.66 BRCA1 BRCA2 CCND1 ESR1 TP53
5 12.64 BRCA2 CCND1 CDH1 CDKN2A EGFR ERBB2
6
Show member pathways
12.58 BRCA1 BRCA2 CCND1 CDH1 CDKN2A EGFR
7
Show member pathways
12.48 CCND1 CDH1 EGFR ERBB2 TP53
8 12.45 BRCA1 BRCA2 CCND1 CDKN2A TP53
9 12.39 CCND1 CDKN2A PPP3R1 TP53
10 12.36 BRCA1 CCND1 CDKN2A EGFR ERBB2 TP53
11
Show member pathways
12.34 BRCA1 CCND1 CDKN2A TP53
12 12.33 CCND1 CDH1 CDKN2A TP53
13
Show member pathways
12.27 CCND1 EGFR ERBB2 ESR1
14 12.21 CCND1 EGFR ERBB2 ESR1 TP53
15 12.14 CCND1 CDH1 EGFR TP53
16 12.12 CCND1 CDKN2A PPP3R1 TP53
17
Show member pathways
12.12 BRCA1 CCND1 CDKN2A ESR1 PGR
18 12.11 CCND1 EGFR ERBB2 TP53
19
Show member pathways
12.03 CCND1 EGFR ERBB2
20
Show member pathways
11.99 BRCA1 BRCA2 CCND1 CDH1 CDKN2A EGFR
21 11.92 CCND1 CDKN2A ERBB2 TP53
22 11.89 CCND1 CDKN2A EGFR TP53
23 11.89 BRCA1 BRCA2 CCND1 CDH1 EGFR ESR1
24
Show member pathways
11.87 EGFR ERBB2 ESR1 PGR
25
Show member pathways
11.83 EGFR ERBB2 ESR1
26 11.82 BRCA1 CCND1 EGFR
27
Show member pathways
11.77 BRCA1 BRCA2 TP53
28 11.74 KRT14 KRT17 KRT5 TP53
29 11.7 CDH1 EGFR ERBB2
30
Show member pathways
11.68 CCND1 EGFR ESR1
31 11.66 BRCA1 CDKN2A ERBB2 TP53
32 11.64 BRCA1 ERBB2 TP53
33 11.63 CCND1 EGFR ESR1
34 11.62 EGFR ERBB2 TP53
35 11.54 BRCA1 CCND1 ERBB2 S100A7
36 11.51 BRCA1 CCND1 TP53
37 11.42 BRCA1 CCND1 TP53
38 11.38 CCND1 CDKN2A EGFR TP53
39 11.34 BRCA2 CCND1 ESR1
40 11.3 CCND1 CDH1 CDKN2A EGFR ERBB2 TP53
41 11.26 BRCA1 CCND1 TP53
42 11.23 CDH1 EGFR ERBB2

GO Terms for Pre-Malignant Neoplasm

Cellular components related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.77 BRCA2 CCND1 CDKN2A ERBB2 ESR1 KRT14
2 cytoplasm GO:0005737 9.53 BRCA1 BRCA2 CCND1 CDH1 CDKN2A EGFR
3 nucleus GO:0005634 10 BRCA1 BRCA2 CCND1 CDKN2A EGFR ERBB2

Biological processes related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cell cycle GO:0007049 9.95 BRCA1 BRCA2 CCND1 CDKN2A INSM1 TP53
2 positive regulation of gene expression GO:0010628 9.89 BRCA1 CDKN2A ERBB2 PIP TP53
3 positive regulation of cell growth GO:0030307 9.72 EGFR ERBB2 KRT17
4 response to estrogen GO:0043627 9.7 BRCA1 CCND1 ESR1
5 positive regulation of transcription, DNA-templated GO:0045893 9.7 BRCA1 BRCA2 CDH1 CDKN2A EGFR ESR1
6 replicative senescence GO:0090399 9.58 CDKN2A TP53
7 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.57 ESR1 TP53
8 hemidesmosome assembly GO:0031581 9.56 KRT14 KRT5
9 mitotic G1 DNA damage checkpoint GO:0031571 9.54 CCND1 TP53
10 positive regulation of cell cycle arrest GO:0071158 9.5 BRCA1 INSM1 TP53
11 negative regulation of immature T cell proliferation in thymus GO:0033088 9.46 CDKN2A ERBB2
12 cellular response to indole-3-methanol GO:0071681 9.43 BRCA1 CDH1
13 response to X-ray GO:0010165 9.43 BRCA2 CCND1 TP53
14 chordate embryonic development GO:0043009 9.4 BRCA1 BRCA2
15 response to UV-A GO:0070141 9.37 CCND1 EGFR
16 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.13 BRCA1 BRCA2 TP53
17 epidermis development GO:0008544 9.02 EGFR KRT14 KRT17 KRT5 S100A7
18 positive regulation of transcription by RNA polymerase II GO:0045944 10.05 BRCA1 CDKN2A EGFR ESR1 PGR PPP3R1

Molecular functions related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.72 CCND1 CDKN2A EGFR ESR1 TP53
2 identical protein binding GO:0042802 9.7 BRCA2 CDH1 EGFR ERBB2 ESR1 PGR
3 protein phosphatase binding GO:0019903 9.54 EGFR ERBB2 TP53
4 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.43 EGFR ERBB2 ESR1
5 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.4 EGFR ERBB2
6 enzyme binding GO:0019899 9.1 BRCA1 CCND1 EGFR ESR1 PGR TP53
7 nitric-oxide synthase regulator activity GO:0030235 8.96 EGFR ESR1

Sources for Pre-Malignant Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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