Pre-Malignant Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PRM023 MIFTS: 33	Pre-Malignant Neoplasm Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases
Genes Related diseases Pathways Download Expand all tables

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Aliases & Classifications for Pre-Malignant Neoplasm

MalaCards integrated aliases for Pre-Malignant Neoplasm:

Name: Pre-Malignant Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Oral diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060071

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Summaries for Pre-Malignant Neoplasm

Disease Ontology : ¹² A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer.

MalaCards based summary : Pre-Malignant Neoplasm is related to conjunctival intraepithelial neoplasm and scirrhous adenocarcinoma. An important gene associated with Pre-Malignant Neoplasm is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are GPCR Pathway and Circadian entrainment. Related phenotypes are Decreased viability in esophageal squamous lineage and Increased cell death HMECs cells

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Related Diseases for Pre-Malignant Neoplasm

Diseases in the Lip Cancer family:

Pre-Malignant Neoplasm	Lip Carcinoma in Situ
in Situ Carcinoma	Eye Carcinoma in Situ

Diseases related to Pre-Malignant Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 213)

#	Related Disease	Score	Top Affiliating Genes
1	conjunctival intraepithelial neoplasm	11.1
2	scirrhous adenocarcinoma	11.1	ERBB2 PGR
3	breast apocrine carcinoma	11.1	ERBB2 PGR
4	endometrium carcinoma in situ	11.0	PGR TP53
5	breast intraductal proliferative lesion	11.0	EGFR ERBB2
6	vulvar syringoma	11.0	ESR1 PGR
7	lung leiomyoma	11.0	ESR1 PGR
8	endometrial clear cell adenocarcinoma	11.0	ESR1 TP53
9	brain ependymoma	11.0	EGFR TP53
10	vulvar benign neoplasm	11.0	ESR1 PGR
11	trigonitis	11.0	ESR1 PGR
12	breast mucoepidermoid carcinoma	11.0	ERBB2 PGR
13	brain stem astrocytic neoplasm	10.9	CDKN2A TP53
14	vulvar leiomyoma	10.9	ESR1 PGR
15	glassy cell carcinoma of the cervix	10.9	ERBB2 ESR1 PGR
16	gallbladder squamous cell carcinoma	10.9	ERBB2 TP53
17	gastric papillary adenocarcinoma	10.9	ERBB2 TP53
18	vestibular gland benign neoplasm	10.9	ESR1 PGR TP53
19	bartholin's gland adenoma	10.9	ESR1 PGR TP53
20	progesterone-receptor positive breast cancer	10.9	ERBB2 ESR1 PGR
21	breast metaplastic carcinoma	10.9	ERBB2 KRT5 PGR
22	uterine body mixed cancer	10.9	ERBB2 PGR TP53
23	intracystic papillary adenoma	10.9	EGFR ERBB2 PGR
24	progesterone-receptor negative breast cancer	10.9	EGFR ERBB2 PGR
25	inverted transitional papilloma	10.9	CDKN2A KRT5
26	cervical carcinosarcoma	10.9	ESR1 PGR TP53
27	vulvar dystrophy	10.9	CDKN2A PGR
28	adenosarcoma	10.9	ESR1 PGR TP53
29	hereditary site-specific ovarian cancer syndrome	10.8	BRCA1 BRCA2
30	breast cystic hypersecretory carcinoma	10.8	CDH1 ERBB2 KRT5
31	breast secretory carcinoma	10.8	ERBB2 KRT5 PGR
32	esophageal adenosquamous carcinoma	10.8	CDH1 KRT5
33	endometrial mucinous adenocarcinoma	10.8	CDKN2A ESR1 PGR
34	adenoid basal cell carcinoma	10.8	CDKN2A ESR1 PGR
35	serous cystadenocarcinoma	10.8	ERBB2 PGR TP53
36	vulvar intraepithelial neoplasia	10.8	CDH1 KRT5 TP53
37	epidermolysis bullosa simplex, autosomal recessive 1	10.8	KRT14 KRT5
38	keratinizing squamous cell carcinoma	10.8	CDKN2A KRT5 TP53
39	barrett's adenocarcinoma	10.8	CDKN2A ERBB2 TP53
40	cystadenocarcinoma	10.8	ERBB2 PGR TP53
41	schneiderian carcinoma	10.8	CDKN2A KRT5 TP53
42	papillary serous adenocarcinoma	10.8	BRCA1 PGR TP53
43	comedo carcinoma	10.8	ERBB2 ESR1
44	cerebral convexity meningioma	10.8	CDH1 TP53
45	necrotizing sialometaplasia	10.8	CDKN2A KRT5 TP53
46	oropharynx cancer	10.8	CDKN2A EGFR TP53
47	optic nerve neoplasm	10.8	CDKN2A KRT5 TP53
48	malignant spiradenoma	10.8	KRT5 TP53
49	spindle cell carcinoma	10.8	CDH1 KRT5 PGR
50	ovarian serous cystadenocarcinoma	10.7	ERBB2 PGR TP53

Graphical network of the top 20 diseases related to Pre-Malignant Neoplasm:

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Symptoms & Phenotypes for Pre-Malignant Neoplasm

GenomeRNAi Phenotypes related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability in esophageal squamous lineage	GR00235-A	9.7	BRCA1 BRCA2 CCND1 CDH1 CDKN2A ERBB2
2	Increased cell death HMECs cells	GR00103-A-0	9.1	BRCA1 EGFR PGR PIP S100A7 TP53

MGI Mouse Phenotypes related to Pre-Malignant Neoplasm:

⁴⁶ (show all 22)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.52	SERPIND1 TP53 BRCA2 ANXA8L1 BRCA1 CCND1
2	digestive/alimentary	MP:0005381	10.45	TP53 BRCA2 BRCA1 CCND1 ERBB2 CDH1
3	growth/size/body region	MP:0005378	10.42	PPP3R1 TP53 BRCA2 BRCA1 CCND1 CDKN2A
4	cardiovascular system	MP:0005385	10.41	PPP3R1 SERPIND1 TP53 BRCA1 CCND1 CDH1
5	endocrine/exocrine gland	MP:0005379	10.4	PPP3R1 TP53 BRCA2 BRCA1 CCND1 CDH1
6	homeostasis/metabolism	MP:0005376	10.4	TP53 PPP3R1 SERPIND1 CCND1 BRCA2 BRCA1
7	mortality/aging	MP:0010768	10.39	PPP3R1 SERPIND1 TP53 BRCA2 BRCA1 CCND1
8	hematopoietic system	MP:0005397	10.38	PPP3R1 SERPIND1 TP53 BRCA2 ANXA8L1 BRCA1
9	immune system	MP:0005387	10.36	TP53 PPP3R1 ANXA8L1 BRCA2 BRCA1 CCND1
10	behavior/neurological	MP:0005386	10.35	TP53 PPP3R1 BRCA1 CCND1 BRCA2 CDKN2A
11	integument	MP:0010771	10.34	TP53 BRCA2 BRCA1 CCND1 CDH1 EGFR
12	embryo	MP:0005380	10.27	TP53 PPP3R1 BRCA2 BRCA1 CDKN2A CDH1
13	craniofacial	MP:0005382	10.19	TP53 CCND1 EGFR ERBB2 INSM1 KRT14
14	neoplasm	MP:0002006	10.14	TP53 BRCA2 BRCA1 CCND1 CDH1 EGFR
15	muscle	MP:0005369	10.09	TP53 SERPIND1 BRCA1 CDKN2A EGFR ESR1
16	limbs/digits/tail	MP:0005371	10.08	TP53 BRCA2 BRCA1 EGFR ESR1 ERBB2
17	no phenotypic analysis	MP:0003012	10.02	TP53 CDKN2A CDH1 EGFR ESR1 INSM1
18	normal	MP:0002873	9.97	TP53 CCND1 BRCA2 BRCA1 EGFR CDH1
19	reproductive system	MP:0005389	9.93	TP53 BRCA2 BRCA1 CCND1 CDKN2A CDH1
20	pigmentation	MP:0001186	9.73	TP53 BRCA1 EGFR CDKN2A KRT14 KRT17
21	respiratory system	MP:0005388	9.65	TP53 CCND1 BRCA1 CDKN2A EGFR KRT14
22	skeleton	MP:0005390	9.32	TP53 CCND1 BRCA2 BRCA1 EGFR CDKN2A

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Drugs & Therapeutics for Pre-Malignant Neoplasm

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	EUS-guided Fine Needle Biopsy With a New Core Histology Needle Versus Conventional Fine Needle Aspiration	Completed	NCT01774162	Not Applicable

Search NIH Clinical Center for Pre-Malignant Neoplasm

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Genetic Tests for Pre-Malignant Neoplasm

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Anatomical Context for Pre-Malignant Neoplasm

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Publications for Pre-Malignant Neoplasm

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Genes for Pre-Malignant Neoplasm

Genes related to Pre-Malignant Neoplasm (0 elite genes):

(show all 21)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	18.34	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	ESR1	Estrogen Receptor 1	Protein Coding	17.81	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	PGR	Progesterone Receptor	Protein Coding	17.76	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	TP53	Tumor Protein P53	Protein Coding	17.1	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	KRT5	Keratin 5	Protein Coding	17.03	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	EGFR	Epidermal Growth Factor Receptor	Protein Coding	16.85	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	CDH1	Cadherin 1	Protein Coding	16.69	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	16.55	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	KRT17	Keratin 17	Protein Coding	16.29	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	BRCA1	BRCA1, DNA Repair Associated	Protein Coding	16.2	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	KRT14	Keratin 14	Protein Coding	16.18	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	SERPIND1	Serpin Family D Member 1	Protein Coding	16.02	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	BRCA2	BRCA2, DNA Repair Associated	Protein Coding	16.02	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
14	CCND1	Cyclin D1	Protein Coding	15.82	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
15	ANXA8L1	Annexin A8 Like 1	Protein Coding	7.69	DISEASES inferred ¹⁵ ¹⁵
16	S100A7	S100 Calcium Binding Protein A7	Protein Coding	6.08	DISEASES inferred ¹⁵
17	PDPN	Podoplanin	Protein Coding	6.02	DISEASES inferred ¹⁵
18	INSM1	INSM Transcriptional Repressor 1	Protein Coding	5.94	DISEASES inferred ¹⁵
19	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	5.81	DISEASES inferred ¹⁵
20	PIP	Prolactin Induced Protein	Protein Coding	5.74	DISEASES inferred ¹⁵
21	CCL27	C-C Motif Chemokine Ligand 27	Protein Coding	5.6	DISEASES inferred ¹⁵

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Variations for Pre-Malignant Neoplasm

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Expression for Pre-Malignant Neoplasm

Search GEO for disease gene expression data for Pre-Malignant Neoplasm.

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Pathways for Pre-Malignant Neoplasm

Pathways related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

(show all 42)

#	Super pathways	Score	Top Affiliating Genes
1	GPCR Pathway ⁶⁴ Show member pathways Breast Cancer Regulation by Stathmin1 ⁶⁴ Estrogen Pathway ⁶⁴ NFAT in Immune Response ⁶⁴ P2Y Receptor Signaling ⁶⁴ Pancreatic Adenocarcinoma ⁶⁴ Paxillin Interactions ⁶⁴ Ras Pathway ⁶⁴	13.7	BRCA1 BRCA2 CCND1 CDKN2A EGFR ERBB2
2	Circadian entrainment ³⁷ Show member pathways Cholinergic synapse ³⁷ Dopaminergic synapse ³⁷ Estrogen signaling pathway ³⁷ Glutamatergic synapse ³⁷ Relaxin receptors ⁶⁶ Relaxin signaling pathway ³⁷ Synaptic Neurotransmission Pathways: Glutamatergic Excitation ⁶⁵	12.97	EGFR ESR1 KRT14 KRT17 PGR PPP3R1
3	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.72	BRCA2 CCND1 CDH1 CDKN2A EGFR ERBB2
4	Chks in Checkpoint Regulation ⁶⁴ Show member pathways DNA Repair Mechanisms ⁶⁴ Estrogen-mediated S-Phase Entry ⁶⁴ G2-M Phase Transition ⁶⁴ Parkinson's Disease Pathway ⁶⁴ SREBP Proteolysis ⁶⁴	12.66	BRCA1 BRCA2 CCND1 ESR1 TP53
5	Pathways in cancer ³⁷	12.64	BRCA2 CCND1 CDH1 CDKN2A EGFR ERBB2
6	Glioma ³⁷ Show member pathways EGFR tyrosine kinase inhibitor resistance ³⁷ Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.58	BRCA1 BRCA2 CCND1 CDH1 CDKN2A EGFR
7	Development EGFR signaling pathway ²² Show member pathways Development ERBB-family signaling ²² EGF Pathway ⁶⁴ EGFR Signaling Pathway ⁶⁷ ErbB receptor signaling network ¹	12.48	CCND1 CDH1 EGFR ERBB2 TP53
8	DNA Damage ⁴	12.45	BRCA1 BRCA2 CCND1 CDKN2A TP53
9	HTLV-I infection ³⁷	12.39	CCND1 CDKN2A PPP3R1 TP53
10	MicroRNAs in cancer ³⁷	12.36	BRCA1 CCND1 CDKN2A EGFR ERBB2 TP53
11	DNA Damage Response ¹ Show member pathways miRNA Regulation of DNA Damage Response ¹ p53 signaling pathway ³⁷	12.34	BRCA1 CCND1 CDKN2A TP53
12	Cell cycle ¹ ³⁷	12.33	CCND1 CDH1 CDKN2A TP53
13	Development Ligand-independent activation of ESR1 and ESR2 ²² Show member pathways Transcription CREB pathway ²² Transcription PPAR Pathway ²²	12.27	CCND1 EGFR ERBB2 ESR1
14	Proteoglycans in cancer ³⁷	12.21	CCND1 EGFR ERBB2 ESR1 TP53
15	Colorectal Cancer Metastasis ⁶⁴	12.14	CCND1 CDH1 EGFR TP53
16	Cellular senescence (KEGG) ³⁷	12.12	CCND1 CDKN2A PPP3R1 TP53
17	Cell cycle Role of SCF complex in cell cycle regulation ²² Show member pathways Cell cycle ESR1 regulation of G1/S transition ²² Cell cycle Regulation of G1/S transition (part 1) ²² Immune response MIF-JAB1 signaling ²²	12.12	BRCA1 CCND1 CDKN2A ESR1 PGR
18	AKT Signaling Pathway ⁶⁷	12.11	CCND1 EGFR ERBB2 TP53
19	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁵ Show member pathways Akt Signaling Pathway ⁶⁵	12.03	CCND1 EGFR ERBB2
20	Gastric cancer ³⁷ Show member pathways Breast cancer ³⁷ Hepatocellular carcinoma ³⁷	11.99	BRCA1 BRCA2 CCND1 CDH1 CDKN2A EGFR
21	DNA Damage Response (only ATM dependent) ¹	11.92	CCND1 CDKN2A ERBB2 TP53
22	Glioblastoma Multiforme ⁶⁴	11.89	CCND1 CDKN2A EGFR TP53
23	Integrated Breast Cancer Pathway ¹	11.89	BRCA1 BRCA2 CCND1 CDH1 EGFR ESR1
24	Signaling by ERBB4 ⁶⁶ Show member pathways Downregulation of ERBB4 signaling ⁶⁶ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁶	11.87	EGFR ERBB2 ESR1 PGR
25	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors ⁶⁶ Show member pathways Activation of the TFAP2 (AP-2) family of transcription factors ⁶⁶ Negative regulation of activity of TFAP2 (AP-2) family transcription factors ⁶⁶ TFAP2 (AP-2) family regulates transcription of cell cycle factors ⁶⁶ TFAP2 (AP-2) family regulates transcription of growth factors and their receptors ⁶⁶ TFAP2 (AP-2) family regulates transcription of other transcription factors ⁶⁶ TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation ⁶⁶	11.83	EGFR ERBB2 ESR1
26	Androgen receptor signaling pathway ¹	11.82	BRCA1 CCND1 EGFR
27	BRCA1 Pathway ⁶⁴ Show member pathways Fanconi's Anaemia Pathway ⁶⁴	11.77	BRCA1 BRCA2 TP53
28	Glucocorticoid receptor regulatory network ¹	11.74	KRT14 KRT17 KRT5 TP53
29	Adherens junction ³⁷	11.7	CDH1 EGFR ERBB2
30	Transcription Ligand-dependent activation of the ESR1/SP pathway ²² Show member pathways Development Ligand-dependent activation of the ESR1/AP-1 pathway ²²	11.68	CCND1 EGFR ESR1
31	Platinum drug resistance ³⁷	11.66	BRCA1 CDKN2A ERBB2 TP53
32	Pathways Affected in Adenoid Cystic Carcinoma ¹	11.64	BRCA1 ERBB2 TP53
33	Regulation of Telomerase ¹	11.63	CCND1 EGFR ESR1
34	Central carbon metabolism in cancer ³⁷	11.62	EGFR ERBB2 TP53
35	Validated targets of C-MYC transcriptional repression ¹	11.54	BRCA1 CCND1 ERBB2 S100A7
36	Hepatitis C and Hepatocellular Carcinoma ¹	11.51	BRCA1 CCND1 TP53
37	DNA damage_ATM/ATR regulation of G1/S checkpoint ²²	11.42	BRCA1 CCND1 TP53
38	Photodynamic therapy-induced AP-1 survival signaling. ¹	11.38	CCND1 CDKN2A EGFR TP53
39	FOXM1 transcription factor network ¹	11.34	BRCA2 CCND1 ESR1
40	Bladder cancer ³⁷ ¹	11.3	CCND1 CDH1 CDKN2A EGFR ERBB2 TP53
41	GADD45 Pathway ⁶⁴	11.26	BRCA1 CCND1 TP53
42	a6b1 and a6b4 Integrin signaling ¹	11.23	CDH1 EGFR ERBB2

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GO Terms for Pre-Malignant Neoplasm

Cellular components related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:0005829	9.77	BRCA2 CCND1 CDKN2A ERBB2 ESR1 KRT14
2	cytoplasm	GO:0005737	9.53	BRCA1 BRCA2 CCND1 CDH1 CDKN2A EGFR
3	nucleus	GO:0005634	10	BRCA1 BRCA2 CCND1 CDKN2A EGFR ERBB2

Biological processes related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

(show all 18)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell cycle	GO:0007049	9.95	BRCA1 BRCA2 CCND1 CDKN2A INSM1 TP53
2	positive regulation of gene expression	GO:0010628	9.89	BRCA1 CDKN2A ERBB2 PIP TP53
3	positive regulation of cell growth	GO:0030307	9.72	EGFR ERBB2 KRT17
4	response to estrogen	GO:0043627	9.7	BRCA1 CCND1 ESR1
5	positive regulation of transcription, DNA-templated	GO:0045893	9.7	BRCA1 BRCA2 CDH1 CDKN2A EGFR ESR1
6	replicative senescence	GO:0090399	9.58	CDKN2A TP53
7	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	GO:0045899	9.57	ESR1 TP53
8	hemidesmosome assembly	GO:0031581	9.56	KRT14 KRT5
9	mitotic G1 DNA damage checkpoint	GO:0031571	9.54	CCND1 TP53
10	positive regulation of cell cycle arrest	GO:0071158	9.5	BRCA1 INSM1 TP53
11	negative regulation of immature T cell proliferation in thymus	GO:0033088	9.46	CDKN2A ERBB2
12	cellular response to indole-3-methanol	GO:0071681	9.43	BRCA1 CDH1
13	response to X-ray	GO:0010165	9.43	BRCA2 CCND1 TP53
14	chordate embryonic development	GO:0043009	9.4	BRCA1 BRCA2
15	response to UV-A	GO:0070141	9.37	CCND1 EGFR
16	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	9.13	BRCA1 BRCA2 TP53
17	epidermis development	GO:0008544	9.02	EGFR KRT14 KRT17 KRT5 S100A7
18	positive regulation of transcription by RNA polymerase II	GO:0045944	10.05	BRCA1 CDKN2A EGFR ESR1 PGR PPP3R1

Molecular functions related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein kinase binding	GO:0019901	9.72	CCND1 CDKN2A EGFR ESR1 TP53
2	identical protein binding	GO:0042802	9.7	BRCA2 CDH1 EGFR ERBB2 ESR1 PGR
3	protein phosphatase binding	GO:0019903	9.54	EGFR ERBB2 TP53
4	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:0046934	9.43	EGFR ERBB2 ESR1
5	obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity	GO:0004716	9.4	EGFR ERBB2
6	enzyme binding	GO:0019899	9.1	BRCA1 CCND1 EGFR ESR1 PGR TP53
7	nitric-oxide synthase regulator activity	GO:0030235	8.96	EGFR ESR1

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Sources for Pre-Malignant Neoplasm

¹ BioSystems

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⁶¹ PharmGKB

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⁷¹ TGDB

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