MCID: PRM023
MIFTS: 36

Pre-Malignant Neoplasm

Categories: Cancer diseases, Eye diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Pre-Malignant Neoplasm

MalaCards integrated aliases for Pre-Malignant Neoplasm:

Name: Pre-Malignant Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060071

Summaries for Pre-Malignant Neoplasm

Disease Ontology : 12 A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer.

MalaCards based summary : Pre-Malignant Neoplasm is related to conjunctival intraepithelial neoplasm and intracystic papillary adenoma. An important gene associated with Pre-Malignant Neoplasm is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are GPCR Pathway and Circadian entrainment. Affiliated tissues include lung, skin and eye, and related phenotypes are Decreased viability in esophageal squamous lineage and Increased cell death HMECs cells

Related Diseases for Pre-Malignant Neoplasm

Diseases in the Lip Cancer family:

Pre-Malignant Neoplasm Lip Carcinoma in Situ
in Situ Carcinoma Eye Carcinoma in Situ

Diseases related to Pre-Malignant Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 240)
# Related Disease Score Top Affiliating Genes
1 conjunctival intraepithelial neoplasm 11.2
2 intracystic papillary adenoma 10.4 ERBB2 PGR
3 comedo carcinoma 10.4 ERBB2 ESR1
4 vestibular gland benign neoplasm 10.4 ESR1 PGR
5 vulvar benign neoplasm 10.4 ESR1 PGR
6 scirrhous adenocarcinoma 10.4 ERBB2 PGR
7 trigonitis 10.4 ESR1 PGR
8 vulvar syringoma 10.4 ESR1 PGR
9 pleomorphic adenoma carcinoma 10.4 ERBB2 TP53
10 breast apocrine carcinoma 10.4 ERBB2 PGR
11 lung leiomyoma 10.4 ESR1 PGR
12 vulvar leiomyoma 10.4 ESR1 PGR
13 bartholin's gland adenoma 10.4 ESR1 PGR
14 gastric papillary adenocarcinoma 10.4 ERBB2 TP53
15 breast malignant phyllodes tumor 10.4 PGR TP53
16 endometrium carcinoma in situ 10.4 PGR TP53
17 breast intraductal proliferative lesion 10.4 EGFR ERBB2
18 malignant spiradenoma 10.3 KRT5 TP53
19 vulvar dystrophy 10.3 CDKN2A PGR
20 brain ependymoma 10.3 EGFR TP53
21 bizarre leiomyoma 10.3 CDKN2A PGR
22 cerebral convexity meningioma 10.3 CDH1 TP53
23 esophageal adenosquamous carcinoma 10.3 CDH1 KRT5
24 inverted transitional papilloma 10.3 CDKN2A KRT5
25 optic nerve sheath meningioma 10.3 CDKN2A KRT5
26 epidermolysis bullosa simplex, autosomal recessive 1 10.3 KRT14 KRT5
27 anaplastic oligodendroglioma 10.3 CDKN2A EGFR
28 malignant peritoneal mesothelioma 10.3 CDKN2A EGFR
29 lichen planopilaris 10.3 KRT14 KRT5
30 basal cell carcinoma, infundibulocystic 10.3 KRT14 KRT17
31 serous cystadenocarcinoma 10.3 ERBB2 PGR TP53
32 cystadenocarcinoma 10.3 ERBB2 PGR TP53
33 ovarian serous cystadenocarcinoma 10.3 ERBB2 PGR TP53
34 tonsil squamous cell carcinoma 10.3 CCND1 CDKN2A
35 adenomyosis 10.3 CDH1 ESR1 PGR
36 papillary carcinoma 10.3 CDH1 ERBB2 PGR
37 breast reconstruction 10.3 BRCA1 BRCA2
38 bowenoid papulosis 10.3 CCND1 CDKN2A
39 glassy cell carcinoma of the cervix 10.3 ERBB2 ESR1 PGR
40 barrett's adenocarcinoma 10.3 CDKN2A ERBB2 TP53
41 adenosquamous carcinoma 10.3 EGFR KRT5 TP53
42 carcinosarcoma 10.3 ERBB2 PGR TP53
43 colorectal adenocarcinoma 10.3 CDH1 EGFR TP53
44 respiratory system disease 10.3 CDH1 EGFR TP53
45 pleomorphic adenoma 10.3 ERBB2 KRT14 TP53
46 small cell carcinoma 10.3 CDKN2A EGFR TP53
47 intrahepatic cholangiocarcinoma 10.3 CDH1 EGFR TP53
48 supratentorial cancer 10.3 CDKN2A EGFR TP53
49 grade iii astrocytoma 10.3 CDKN2A EGFR TP53
50 central nervous system cancer 10.3 CDKN2A EGFR TP53

Graphical network of the top 20 diseases related to Pre-Malignant Neoplasm:



Diseases related to Pre-Malignant Neoplasm

Symptoms & Phenotypes for Pre-Malignant Neoplasm

GenomeRNAi Phenotypes related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.7 BRCA1 BRCA2 CCND1 CDH1 CDKN2A ERBB2
2 Increased cell death HMECs cells GR00103-A-0 9.1 BRCA1 EGFR PGR PIP S100A7 TP53

MGI Mouse Phenotypes related to Pre-Malignant Neoplasm:

46 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.52 ANXA8L1 BRCA1 BRCA2 CCND1 CDH1 CDKN2A
2 digestive/alimentary MP:0005381 10.45 BRCA1 BRCA2 CCND1 CDH1 CDKN2A EGFR
3 growth/size/body region MP:0005378 10.42 BRCA1 BRCA2 CCND1 CDH1 CDKN2A EGFR
4 cardiovascular system MP:0005385 10.41 BRCA1 CCND1 CDH1 CDKN2A EGFR ERBB2
5 endocrine/exocrine gland MP:0005379 10.4 BRCA1 BRCA2 CCND1 CDH1 CDKN2A EGFR
6 homeostasis/metabolism MP:0005376 10.4 BRCA1 BRCA2 CCND1 CDH1 CDKN2A EGFR
7 mortality/aging MP:0010768 10.39 BRCA1 BRCA2 CCND1 CDH1 CDKN2A EGFR
8 hematopoietic system MP:0005397 10.38 ANXA8L1 BRCA1 BRCA2 CCND1 CDKN2A EGFR
9 immune system MP:0005387 10.36 ANXA8L1 BRCA1 BRCA2 CCND1 CDH1 CDKN2A
10 behavior/neurological MP:0005386 10.35 BRCA1 BRCA2 CCND1 CDKN2A ERBB2 ESR1
11 integument MP:0010771 10.34 BRCA1 BRCA2 CCND1 CDH1 CDKN2A EGFR
12 embryo MP:0005380 10.27 BRCA1 BRCA2 CDH1 CDKN2A EGFR ERBB2
13 craniofacial MP:0005382 10.19 CCND1 EGFR ERBB2 INSM1 KRT14 KRT17
14 neoplasm MP:0002006 10.14 BRCA1 BRCA2 CCND1 CDH1 CDKN2A EGFR
15 muscle MP:0005369 10.09 BRCA1 CDKN2A EGFR ERBB2 ESR1 PDPN
16 limbs/digits/tail MP:0005371 10.08 BRCA1 BRCA2 EGFR ERBB2 ESR1 KRT5
17 no phenotypic analysis MP:0003012 10.02 CDH1 CDKN2A EGFR ESR1 INSM1 KRT17
18 normal MP:0002873 9.97 BRCA1 BRCA2 CCND1 CDH1 EGFR ERBB2
19 reproductive system MP:0005389 9.93 BRCA1 BRCA2 CCND1 CDH1 CDKN2A EGFR
20 pigmentation MP:0001186 9.73 BRCA1 CDKN2A EGFR KRT14 KRT17 TP53
21 respiratory system MP:0005388 9.65 BRCA1 CCND1 CDKN2A EGFR ERBB2 ESR1
22 skeleton MP:0005390 9.32 BRCA1 BRCA2 CCND1 CDKN2A EGFR ERBB2

Drugs & Therapeutics for Pre-Malignant Neoplasm

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 EUS-guided Fine Needle Biopsy With a New Core Histology Needle Versus Conventional Fine Needle Aspiration Completed NCT01774162 Not Applicable

Search NIH Clinical Center for Pre-Malignant Neoplasm

Genetic Tests for Pre-Malignant Neoplasm

Anatomical Context for Pre-Malignant Neoplasm

MalaCards organs/tissues related to Pre-Malignant Neoplasm:

41
Lung, Skin, Eye, Ovary, Tonsil, Prostate, Cervix

Publications for Pre-Malignant Neoplasm

Variations for Pre-Malignant Neoplasm

Expression for Pre-Malignant Neoplasm

Search GEO for disease gene expression data for Pre-Malignant Neoplasm.

Pathways for Pre-Malignant Neoplasm

Pathways related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 BRCA1 BRCA2 CCND1 CDKN2A EGFR ERBB2
2
Show member pathways
12.98 EGFR ESR1 KRT14 KRT17 PGR PPP3R1
3
Show member pathways
12.72 BRCA2 CCND1 CDH1 CDKN2A EGFR ERBB2
4
Show member pathways
12.66 BRCA1 BRCA2 CCND1 ESR1 TP53
5 12.64 BRCA2 CCND1 CDH1 CDKN2A EGFR ERBB2
6
Show member pathways
12.58 BRCA1 BRCA2 CCND1 CDH1 CDKN2A EGFR
7
Show member pathways
12.48 CCND1 CDH1 EGFR ERBB2 TP53
8 12.45 BRCA1 BRCA2 CCND1 CDKN2A TP53
9 12.39 CCND1 CDH1 PPP3R1 TP53
10 12.39 CCND1 CDKN2A PPP3R1 TP53
11 12.36 BRCA1 CCND1 CDKN2A EGFR ERBB2 TP53
12
Show member pathways
12.34 BRCA1 CCND1 CDKN2A TP53
13 12.33 CCND1 CDH1 CDKN2A TP53
14
Show member pathways
12.28 CCND1 EGFR ERBB2 ESR1
15 12.21 CCND1 EGFR ERBB2 ESR1 TP53
16
Show member pathways
12.17 CCND1 EGFR ERBB2 TP53
17 12.14 CCND1 CDH1 EGFR TP53
18 12.12 CCND1 CDKN2A PPP3R1 TP53
19
Show member pathways
12.12 BRCA1 CCND1 CDKN2A ESR1 PGR
20 12.08 CCND1 EGFR ERBB2 TP53
21
Show member pathways
11.99 BRCA1 BRCA2 CCND1 CDH1 CDKN2A EGFR
22 11.92 CCND1 CDKN2A ERBB2 TP53
23 11.89 CCND1 CDKN2A EGFR TP53
24 11.89 BRCA1 BRCA2 CCND1 CDH1 EGFR ESR1
25
Show member pathways
11.87 EGFR ERBB2 ESR1 PGR
26
Show member pathways
11.83 EGFR ERBB2 ESR1
27 11.82 BRCA1 CCND1 EGFR
28
Show member pathways
11.77 BRCA1 BRCA2 TP53
29 11.74 KRT14 KRT17 KRT5 TP53
30 11.7 CDH1 EGFR ERBB2
31
Show member pathways
11.68 CCND1 EGFR ESR1
32 11.66 BRCA1 CDKN2A ERBB2 TP53
33 11.65 BRCA1 ERBB2 TP53
34 11.64 CCND1 EGFR ESR1
35 11.63 EGFR ERBB2 TP53
36 11.54 BRCA1 BRCA2 PPP3R1 TP53
37 11.54 BRCA1 CCND1 ERBB2 S100A7
38 11.51 BRCA1 CCND1 TP53
39 11.42 BRCA1 CCND1 TP53
40 11.38 CCND1 CDKN2A EGFR TP53
41 11.34 BRCA2 CCND1 ESR1
42 11.3 CCND1 CDH1 CDKN2A EGFR ERBB2 TP53
43 11.26 BRCA1 CCND1 TP53
44 11.23 CDH1 EGFR ERBB2

GO Terms for Pre-Malignant Neoplasm

Cellular components related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.77 BRCA2 CCND1 CDKN2A ERBB2 ESR1 KRT14
2 cytoplasm GO:0005737 9.53 BRCA1 BRCA2 CCND1 CDH1 CDKN2A EGFR
3 nucleus GO:0005634 10 BRCA1 BRCA2 CCND1 CDKN2A EGFR ERBB2

Biological processes related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.92 BRCA1 CDKN2A ERBB2 PIP TP53
2 cell cycle GO:0007049 9.91 BRCA1 BRCA2 CCND1 CDKN2A INSM1 TP53
3 positive regulation of cell growth GO:0030307 9.75 EGFR ERBB2 KRT17
4 response to estrogen GO:0043627 9.72 BRCA1 CCND1 ESR1
5 positive regulation of transcription, DNA-templated GO:0045893 9.7 BRCA1 BRCA2 CDH1 CDKN2A EGFR ESR1
6 replicative senescence GO:0090399 9.59 CDKN2A TP53
7 hemidesmosome assembly GO:0031581 9.58 KRT14 KRT5
8 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.57 ESR1 TP53
9 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.56 EGFR TP53
10 response to estradiol GO:0032355 9.56 BRCA2 CCND1 EGFR ESR1
11 mitotic G1 DNA damage checkpoint GO:0031571 9.54 CCND1 TP53
12 positive regulation of cell cycle arrest GO:0071158 9.5 BRCA1 INSM1 TP53
13 negative regulation of ERBB signaling pathway GO:1901185 9.49 EGFR ERBB2
14 cellular response to indole-3-methanol GO:0071681 9.48 BRCA1 CDH1
15 negative regulation of immature T cell proliferation in thymus GO:0033088 9.46 CDKN2A ERBB2
16 chordate embryonic development GO:0043009 9.4 BRCA1 BRCA2
17 response to UV-A GO:0070141 9.37 CCND1 EGFR
18 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.13 BRCA1 BRCA2 TP53
19 epidermis development GO:0008544 9.02 EGFR KRT14 KRT17 KRT5 S100A7
20 positive regulation of transcription by RNA polymerase II GO:0045944 10.05 BRCA1 CDKN2A EGFR ESR1 PGR PPP3R1

Molecular functions related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.72 CCND1 CDKN2A EGFR ESR1 TP53
2 protein phosphatase binding GO:0019903 9.58 EGFR ERBB2 TP53
3 identical protein binding GO:0042802 9.56 BRCA1 BRCA2 CDH1 EGFR ERBB2 ESR1
4 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.43 EGFR ERBB2 ESR1
5 nitric-oxide synthase regulator activity GO:0030235 9.37 EGFR ESR1
6 enzyme binding GO:0019899 9.1 BRCA1 CCND1 EGFR ESR1 PGR TP53
7 protein binding GO:0005515 10.09 BRCA1 BRCA2 CCND1 CDH1 CDKN2A EGFR

Sources for Pre-Malignant Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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