Pre-Malignant Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PRM023 MIFTS: 28	Pre-Malignant Neoplasm Categories: Cancer diseases, Eye diseases, Neuronal diseases
Genes Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Pre-Malignant Neoplasm

MalaCards integrated aliases for Pre-Malignant Neoplasm:

Name: Pre-Malignant Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060071

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Summaries for Pre-Malignant Neoplasm

Disease Ontology : ¹² A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer.

MalaCards based summary : Pre-Malignant Neoplasm is related to conjunctival intraepithelial neoplasm and bartholin's gland adenoid cystic carcinoma. An important gene associated with Pre-Malignant Neoplasm is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Related phenotypes are digestive/alimentary and embryo

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Related Diseases for Pre-Malignant Neoplasm

Diseases in the in Situ Carcinoma family:

Pre-Malignant Neoplasm

Eye Carcinoma in Situ

Diseases related to Pre-Malignant Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 474)

#	Related Disease	Score	Top Affiliating Genes
1	conjunctival intraepithelial neoplasm	11.1
2	bartholin's gland adenoid cystic carcinoma	10.6	PGR ESR1
3	uterine corpus adenosarcoma	10.6	PGR ESR1
4	chronic tympanitis	10.6	PGR ESR1
5	glassy cell carcinoma of the cervix	10.6	PGR ESR1 ERBB2
6	breast intraductal papillomatosis	10.6	PGR ESR1 ERBB2
7	nipple carcinoma	10.6	PGR ESR1 ERBB2
8	bartholin's gland adenoma	10.6	TP53 PGR ESR1
9	bartholin's gland benign neoplasm	10.6	TP53 PGR ESR1
10	vestibular gland benign neoplasm	10.6	TP53 PGR ESR1
11	oncocytic breast carcinoma	10.6	PGR ESR1 ERBB2
12	granulomatous endometritis	10.6	PGR ESR1
13	vulvar syringoma	10.6	PGR ESR1
14	fallopian tube clear cell adenocarcinoma	10.6	BRCA2 BRCA1
15	mucoepidermoid esophageal carcinoma	10.6	TP53 KRT5
16	apocrine adenosis of breast	10.6	TP53 PGR ERBB2
17	breast adenoid cystic carcinoma	10.6	PGR ESR1 ERBB2
18	scirrhous adenocarcinoma	10.6	PGR ERBB2 CDH1
19	lipid-rich breast carcinoma	10.6	PGR KRT5 ERBB2
20	breast squamous cell carcinoma	10.6	KRT5 ESR1 ERBB2
21	progesterone-receptor positive breast cancer	10.6	PGR ESR1 ERBB2
22	cervical adenosarcoma	10.5	TP53 PGR ESR1
23	breast mucinous carcinoma	10.5	PGR KRT5 ERBB2
24	lung leiomyoma	10.5	PGR ESR1
25	gastric papillary adenocarcinoma	10.5	TP53 ERBB2
26	gastric diffuse adenocarcinoma	10.5	PGR ERBB2 CDH1
27	retinitis pigmentosa 47	10.5	PGR ESR1 ERBB2
28	linitis plastica	10.5	PGR ERBB2 CDH1
29	parotid gland adenoid cystic carcinoma	10.5	ERBB2 CDKN2A
30	breast cystic hypersecretory carcinoma	10.5	KRT5 ERBB2 CDH1
31	penile urethral cancer	10.5	KRT5 CDKN2A
32	adult type testicular granulosa cell tumor	10.5	PGR ESR1
33	triple-receptor negative breast cancer	10.5	PGR ERBB2 BRCA2
34	cervical clear cell adenocarcinoma	10.5	PGR ESR1
35	familial ovarian cancer	10.5	ESR1 BRCA2 BRCA1
36	biphasic synovial sarcoma	10.5	PGR ESR1 CDH1
37	benign breast adenomyoepithelioma	10.5	KRT5 ESR1 EGFR
38	ovary transitional cell carcinoma	10.5	BRCA2 BRCA1
39	endosalpingiosis	10.5	PGR BRCA2 BRCA1
40	comedo carcinoma	10.5	TP53 PGR ESR1 ERBB2
41	mature teratoma	10.5	TP53 H2AC18 ERBB2
42	pregnancy adenoma	10.5	PGR KRT5
43	cancerophobia	10.5	BRCA2 BRCA1
44	external ear carcinoma	10.5	PGR KRT5
45	endometrial squamous cell carcinoma	10.5	PGR CDKN2A
46	breast papillary carcinoma	10.5	PGR KRT5 ESR1 ERBB2
47	mutagen sensitivity	10.5	TP53 BRCA2 BRCA1
48	intracranial meningioma	10.5	PGR ESR1 CDKN2A
49	nosophobia	10.5	BRCA2 BRCA1
50	papillary carcinoma	10.5	PGR ESR1 ERBB2 CDH1

Graphical network of the top 20 diseases related to Pre-Malignant Neoplasm:

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Symptoms & Phenotypes for Pre-Malignant Neoplasm

MGI Mouse Phenotypes related to Pre-Malignant Neoplasm:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.97	BRCA1 BRCA2 CDH1 CDKN2A EGFR ERBB2
2	embryo	MP:0005380	9.91	BRCA1 BRCA2 CDH1 CDKN2A EGFR ERBB2
3	integument	MP:0010771	9.9	BRCA1 BRCA2 CDH1 CDKN2A EGFR ERBB2
4	limbs/digits/tail	MP:0005371	9.56	BRCA1 BRCA2 EGFR ERBB2 ESR1 KRT5
5	neoplasm	MP:0002006	9.28	BRCA1 BRCA2 CDH1 CDKN2A EGFR ERBB2

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Drugs & Therapeutics for Pre-Malignant Neoplasm

Search Clinical Trials , NIH Clinical Center for Pre-Malignant Neoplasm

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Genetic Tests for Pre-Malignant Neoplasm

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Anatomical Context for Pre-Malignant Neoplasm

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Publications for Pre-Malignant Neoplasm

Articles related to Pre-Malignant Neoplasm:

#	Title	Authors	PMID	Year
1	Chemoprevention for keratinocytic (pre)cancers: balancing the risks and benefits. ⁶¹	Hollestein LM...Nijsten T	22782153	2012
2	Natural selection in neoplastic progression of Barrett's esophagus. ⁶¹	Maley CC...Reid BJ	16043360	2005
3	Assessment of cell surface glycoconjugates in normal, benign and malignant human nasal mucosa. ⁶¹	Fang SY...Ohyama M	9532636	1997

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Genes for Pre-Malignant Neoplasm

Genes related to Pre-Malignant Neoplasm (0 elite genes):

(show all 49)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	9.13	DISEASES inferred ¹⁵
2	PGR	Progesterone Receptor	Protein Coding	8.84	DISEASES inferred ¹⁵
3	ESR1	Estrogen Receptor 1	Protein Coding	8.76	DISEASES inferred ¹⁵
4	CT45A10	Cancer/Testis Antigen Family 45 Member A10	Protein Coding	8.43	DISEASES inferred ¹⁵ ¹⁵
5	TP53	Tumor Protein P53	Protein Coding	7.96	DISEASES inferred ¹⁵
6	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	7.85	DISEASES inferred ¹⁵
7	MIR181A1	MicroRNA 181a-1	RNA Gene	7.78	DISEASES inferred ¹⁵ ¹⁵
8	H2AC18	H2A Clustered Histone 18	Protein Coding	7.75	DISEASES inferred ¹⁵ ¹⁵
9	MIR143	MicroRNA 143	RNA Gene	7.65	DISEASES inferred ¹⁵ ¹⁵
10	KRT5	Keratin 5	Protein Coding	7.63	DISEASES inferred ¹⁵
11	CDH1	Cadherin 1	Protein Coding	7.6	DISEASES inferred ¹⁵
12	EGFR	Epidermal Growth Factor Receptor	Protein Coding	7.55	DISEASES inferred ¹⁵
13	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	7.51	DISEASES inferred ¹⁵
14	MIR342	MicroRNA 342	RNA Gene	7.45	DISEASES inferred ¹⁵ ¹⁵
15	MIR17	MicroRNA 17	RNA Gene	7.4	DISEASES inferred ¹⁵ ¹⁵
16	MIR139	MicroRNA 139	RNA Gene	7.38	DISEASES inferred ¹⁵ ¹⁵
17	MIR654	MicroRNA 654	RNA Gene	7.26	DISEASES inferred ¹⁵ ¹⁵
18	MIR142	MicroRNA 142	RNA Gene	7.23	DISEASES inferred ¹⁵ ¹⁵
19	SERPINA3	Serpin Family A Member 3	Protein Coding	7.21	DISEASES inferred ¹⁵ ¹⁵
20	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	7.18	DISEASES inferred ¹⁵
21	MIR193A	MicroRNA 193a	RNA Gene	7.14	DISEASES inferred ¹⁵ ¹⁵
22	CYP19A1	Cytochrome P450 Family 19 Subfamily A Member 1	Protein Coding	7.1	DISEASES inferred ¹⁵
23	MIR299	MicroRNA 299	RNA Gene	7.08	DISEASES inferred ¹⁵ ¹⁵
24	KRT14	Keratin 14	Protein Coding	7.08	DISEASES inferred ¹⁵
25	EGF	Epidermal Growth Factor	Protein Coding	6.97	DISEASES inferred ¹⁵
26	MIR548B	MicroRNA 548b	RNA Gene	6.95	DISEASES inferred ¹⁵ ¹⁵
27	CCND1	Cyclin D1	Protein Coding	6.94	DISEASES inferred ¹⁵
28	CCL27	C-C Motif Chemokine Ligand 27	Protein Coding	6.78	DISEASES inferred ¹⁵
29	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	6.78	DISEASES inferred ¹⁵
30	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	6.76	DISEASES inferred ¹⁵
31	KRT8	Keratin 8	Protein Coding	6.69	DISEASES inferred ¹⁵
32	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	6.66	DISEASES inferred ¹⁵
33	PDPN	Podoplanin	Protein Coding	6.62	DISEASES inferred ¹⁵
34	CTNNB1	Catenin Beta 1	Protein Coding	6.62	DISEASES inferred ¹⁵
35	KRT17	Keratin 17	Protein Coding	6.59	DISEASES inferred ¹⁵
36	PTEN	Phosphatase And Tensin Homolog	Protein Coding	6.57	DISEASES inferred ¹⁵
37	TLR7	Toll Like Receptor 7	Protein Coding	6.57	DISEASES inferred ¹⁵
38	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	6.57	DISEASES inferred ¹⁵
39	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	6.56	DISEASES inferred ¹⁵ ¹⁵
40	S100A7	S100 Calcium Binding Protein A7	Protein Coding	6.55	DISEASES inferred ¹⁵
41	LCOR	Ligand Dependent Nuclear Receptor Corepressor	Protein Coding	6.53	DISEASES inferred ¹⁵ ¹⁵
42	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	6.5	DISEASES inferred ¹⁵
43	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	6.49	DISEASES inferred ¹⁵
44	CD44	CD44 Molecule (Indian Blood Group)	Protein Coding	6.47	DISEASES inferred ¹⁵
45	PIP	Prolactin Induced Protein	Protein Coding	6.41	DISEASES inferred ¹⁵
46	INSM1	INSM Transcriptional Repressor 1	Protein Coding	6.37	DISEASES inferred ¹⁵
47	KRT19	Keratin 19	Protein Coding	6.33	DISEASES inferred ¹⁵
48	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	6.32	DISEASES inferred ¹⁵
49	ACTB	Actin Beta	Protein Coding	6.32	DISEASES inferred ¹⁵

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Variations for Pre-Malignant Neoplasm

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Expression for Pre-Malignant Neoplasm

Search GEO for disease gene expression data for Pre-Malignant Neoplasm.

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Pathways for Pre-Malignant Neoplasm

Pathways related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

(show all 18)

#	Super pathways	Score	Top Affiliating Genes
1	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁶	12.72	TP53 ERBB2 EGFR CDKN2A CDH1 BRCA2
2	Pathways in cancer ³⁶	12.64	TP53 ESR1 ERBB2 EGFR CDKN2A CDH1
3	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.36	TP53 ESR1 ERBB2 EGFR CDKN2A CDH1
4	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.28	TP53 PGR ESR1 ERBB2 EGFR CDKN2A
5	DNA Damage Response ¹ Show member pathways miRNA Regulation of DNA Damage Response ¹ p53 signaling pathway ³⁶	12.2	TP53 MIR181A1 MIR17 CDKN2A BRCA1
6	Proteoglycans in cancer ³⁶	12.15	TP53 ESR1 ERBB2 EGFR
7	Cell cycle Role of SCF complex in cell cycle regulation ²³ Show member pathways Cell cycle ESR1 regulation of G1/S transition ²³ Cell cycle Regulation of G1/S transition (part 1) ²³ Immune response MIF-JAB1 signaling ²³	12.07	PGR ESR1 CDKN2A BRCA1
8	Integrated Breast Cancer Pathway ¹	11.92	TP53 ESR1 EGFR CDH1 BRCA2 BRCA1
9	Signaling by ERBB4 ⁶⁵ Show member pathways Downregulation of ERBB4 signaling ⁶⁵ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁵	11.79	PGR ESR1 ERBB2 EGFR
10	MicroRNAs in cancer ³⁶	11.77	TP53 MIR342 MIR181A1 MIR17 MIR143 ERBB2
11	BRCA1 Pathway ⁶³ Show member pathways Fanconi's Anaemia Pathway ⁶³	11.67	TP53 BRCA2 BRCA1
12	Adherens junction ³⁶	11.59	ERBB2 EGFR CDH1
13	Central carbon metabolism in cancer ³⁶	11.58	TP53 ERBB2 EGFR
14	Bladder cancer ³⁶ ¹	11.58	TP53 ERBB2 EGFR CDKN2A CDH1
15	Platinum drug resistance ³⁶	11.57	TP53 ERBB2 CDKN2A BRCA1
16	Pathways Affected in Adenoid Cystic Carcinoma ¹	11.54	TP53 ERBB2 BRCA1
17	Photodynamic therapy-induced AP-1 survival signaling. ¹	11.39	TP53 EGFR CDKN2A
18	a6b1 and a6b4 Integrin signaling ¹	11.14	ERBB2 EGFR CDH1

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GO Terms for Pre-Malignant Neoplasm

Cellular components related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein-containing complex	GO:0032991	9.43	TP53 ESR1 EGFR CDKN2A BRCA2 BRCA1
2	extracellular space	GO:0005615	9.28	SERPINA3 MIR654 MIR342 MIR181A1 MIR17 MIR143

Biological processes related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of protein kinase B signaling	GO:0051897	9.81	MIR143 ESR1 ERBB2 EGFR
2	negative regulation of gene expression	GO:0010629	9.72	TP53 PGR MIR181A1 MIR17 ESR1
3	double-strand break repair	GO:0006302	9.7	TP53 BRCA2 BRCA1
4	positive regulation of transcription, DNA-templated	GO:0045893	9.7	TP53 ESR1 EGFR CDKN2A CDH1 BRCA2
5	positive regulation of production of miRNAs involved in gene silencing by miRNA	GO:1903800	9.57	TP53 EGFR
6	negative regulation of production of miRNAs involved in gene silencing by miRNA	GO:1903799	9.56	TP53 ESR1
7	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	GO:0045899	9.55	TP53 ESR1
8	intracellular steroid hormone receptor signaling pathway	GO:0030518	9.54	PGR ESR1
9	negative regulation of ERBB signaling pathway	GO:1901185	9.49	ERBB2 EGFR
10	negative regulation of interleukin-1 alpha production	GO:0032690	9.48	MIR181A1 MIR142
11	cellular response to indole-3-methanol	GO:0071681	9.46	CDH1 BRCA1
12	chordate embryonic development	GO:0043009	9.43	BRCA2 BRCA1
13	positive regulation of cell cycle arrest	GO:0071158	9.43	TP53 CDKN2A BRCA1
14	negative regulation of immature T cell proliferation in thymus	GO:0033088	9.4	ERBB2 CDKN2A
15	positive regulation of pulmonary blood vessel remodeling	GO:1905111	9.37	MIR17 MIR143
16	gene silencing by miRNA	GO:0035195	9.17	MIR654 MIR342 MIR181A1 MIR17 MIR143 MIR142
17	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	9.13	TP53 BRCA2 BRCA1

Molecular functions related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.81	TP53 PGR ESR1 ERBB2 EGFR CT45A10
2	enzyme binding	GO:0019899	9.65	TP53 PGR ESR1 EGFR BRCA1
3	ATPase binding	GO:0051117	9.58	PGR ESR1 EGFR
4	mRNA 3'-UTR binding	GO:0003730	9.43	TP53 MIR181A1 MIR17 MIR143 MIR142 MIR139
5	MDM2/MDM4 family protein binding	GO:0097371	9.37	TP53 CDKN2A
6	nitric-oxide synthase regulator activity	GO:0030235	9.32	ESR1 EGFR
7	mRNA binding involved in posttranscriptional gene silencing	GO:1903231	9.17	MIR654 MIR342 MIR181A1 MIR17 MIR143 MIR142

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Sources for Pre-Malignant Neoplasm

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia