MCID: PRM023
MIFTS: 29

Pre-Malignant Neoplasm

Categories: Cancer diseases, Eye diseases, Neuronal diseases
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Aliases & Classifications for Pre-Malignant Neoplasm

MalaCards integrated aliases for Pre-Malignant Neoplasm:

Name: Pre-Malignant Neoplasm 11 14

Classifications:



External Ids:

Disease Ontology 11 DOID:0060071

Summaries for Pre-Malignant Neoplasm

Disease Ontology: 11 A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer.

MalaCards based summary: Pre-Malignant Neoplasm is related to conjunctival intraepithelial neoplasm and breast adenomyoepithelioma. An important gene associated with Pre-Malignant Neoplasm is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Disease and GPCR Pathway. Related phenotypes are growth/size/body region and neoplasm

Related Diseases for Pre-Malignant Neoplasm

Diseases in the Eye Carcinoma in Situ family:

Pre-Malignant Neoplasm

Diseases related to Pre-Malignant Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 555)
# Related Disease Score Top Affiliating Genes
1 conjunctival intraepithelial neoplasm 11.2
2 breast adenomyoepithelioma 10.5 KRT5 KRT14
3 nipple carcinoma 10.5 PGR ESR1 ERBB2
4 breast mucinous cystadenocarcinoma 10.5 PGR ESR1 ERBB2
5 breast fibroadenosis 10.5 PGR ESR1 ERBB2
6 bulbospinal polio 10.5 PGR ESR1 ERBB2
7 spinal polio 10.5 PGR ESR1 ERBB2
8 glycogen-rich clear cell breast carcinoma 10.5 PGR ESR1 ERBB2
9 bartholin's gland adenoma 10.5 TP53 PGR ESR1
10 bartholin's gland benign neoplasm 10.5 TP53 PGR ESR1
11 vestibular gland benign neoplasm 10.5 TP53 PGR ESR1
12 breast cystic hypersecretory carcinoma 10.5 PGR ESR1 ERBB2
13 uterine corpus adenosarcoma 10.5 PGR ESR1
14 lipid-rich breast carcinoma 10.5 PGR KRT5 ERBB2
15 adenosquamous breast carcinoma 10.5 TP53 PGR KRT5
16 scirrhous adenocarcinoma 10.5 PGR ERBB2 CDH1
17 progesterone-receptor negative breast cancer 10.5 PGR ESR1 ERBB2
18 malignant spiradenoma 10.5 TP53 KRT5 ESR1
19 mucoepidermoid esophageal carcinoma 10.5 TP53 KRT5
20 breast mucinous carcinoma 10.5 PGR KRT5 ERBB2
21 cervical adenosarcoma 10.5 TP53 PGR ESR1
22 diffuse peritoneal leiomyomatosis 10.5 PGR ESR1 CYP19A1
23 peritoneal benign neoplasm 10.5 PGR ESR1 CYP19A1
24 tonsillar pillar cancer 10.5 EGFR CDKN2A
25 adult cystic nephroma 10.5 PGR ESR1
26 ovarian serous cystadenofibroma 10.5 TP53 PGR BRCA1
27 ovarian serous adenofibroma 10.5 TP53 PGR BRCA1
28 autosomal dominant generalized epidermolysis bullosa simplex, severe form 10.5 KRT5 KRT14
29 linitis plastica 10.5 PGR ERBB2 CDH1
30 penile urethral cancer 10.5 KRT5 CDKN2A
31 glycogen-rich carcinoma 10.5 PGR KRT14 ERBB2
32 ovarian seromucinous carcinoma 10.5 PGR ESR1 CDKN2A
33 vagina leiomyosarcoma 10.5 PGR ESR1
34 breast squamous cell carcinoma 10.5 PGR KRT5 ESR1 ERBB2
35 vulva basal cell carcinoma 10.5 KRT5 ERBB2 CDKN2A
36 her2-receptor negative breast cancer 10.5 PGR ERBB2
37 gastroesophageal junction adenocarcinoma 10.5 TP53 ERBB2 EGFR
38 hereditary site-specific ovarian cancer syndrome 10.5 BRCA2 BRCA1
39 vulvar benign neoplasm 10.5 PGR ESR1
40 adenoid squamous cell carcinoma 10.5 TP53 KRT5 CDH1
41 breast papillary carcinoma 10.5 PGR KRT5 ESR1 ERBB2
42 ovary transitional cell carcinoma 10.5 BRCA2 BRCA1
43 hereditary breast cancer 10.5 CDH1 BRCA2 BRCA1
44 breast adenoid cystic carcinoma 10.5 PGR KRT5 ESR1 ERBB2
45 pleomorphic carcinoma 10.5 TP53 KRT5 EGFR
46 ovarian cyst 10.5 PGR ESR1 CYP19A1 BRCA1
47 good syndrome 10.5 TP53 ERBB2 EGFR
48 cystitis 10.5 TP53 EGF CDH1
49 estrogen excess 10.5 PGR ESR1 CYP19A1
50 papillary squamous carcinoma 10.5 KRT5 EGFR CDKN2A

Graphical network of the top 20 diseases related to Pre-Malignant Neoplasm:



Diseases related to Pre-Malignant Neoplasm

Symptoms & Phenotypes for Pre-Malignant Neoplasm

MGI Mouse Phenotypes related to Pre-Malignant Neoplasm:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.3 BRCA1 BRCA2 CDH1 CDKN2A CYP19A1 EGF
2 neoplasm MP:0002006 10.26 BRCA1 BRCA2 CDH1 CDKN2A EGFR ERBB2
3 normal MP:0002873 10.21 BRCA1 BRCA2 CDH1 CYP19A1 EGF EGFR
4 endocrine/exocrine gland MP:0005379 10.21 BRCA1 BRCA2 CDH1 CDKN2A CYP19A1 EGF
5 digestive/alimentary MP:0005381 10.18 BRCA1 BRCA2 CDH1 CDKN2A CYP19A1 EGF
6 limbs/digits/tail MP:0005371 10.13 BRCA1 BRCA2 EGFR ERBB2 ESR1 KRT5
7 immune system MP:0005387 10.13 BRCA1 BRCA2 CDH1 CDKN2A CYP19A1 EGF
8 muscle MP:0005369 10.1 BRCA1 CDKN2A CYP19A1 EGFR ERBB2 ESR1
9 cellular MP:0005384 10.1 BRCA1 BRCA2 CDH1 CDKN2A CYP19A1 EGFR
10 embryo MP:0005380 10.06 BRCA1 BRCA2 CDH1 CDKN2A EGFR ERBB2
11 pigmentation MP:0001186 10.01 BRCA1 CDKN2A CYP19A1 EGFR KRT14 TP53
12 reproductive system MP:0005389 9.93 BRCA1 BRCA2 CDH1 CDKN2A CYP19A1 EGF
13 skeleton MP:0005390 9.65 BRCA1 BRCA2 CDKN2A CYP19A1 EGFR ERBB2
14 integument MP:0010771 9.47 BRCA1 BRCA2 CDH1 CDKN2A CYP19A1 EGF

Drugs & Therapeutics for Pre-Malignant Neoplasm

Search Clinical Trials, NIH Clinical Center for Pre-Malignant Neoplasm

Genetic Tests for Pre-Malignant Neoplasm

Anatomical Context for Pre-Malignant Neoplasm

Publications for Pre-Malignant Neoplasm

Articles related to Pre-Malignant Neoplasm:

# Title Authors PMID Year
1
Chemoprevention for keratinocytic (pre)cancers: balancing the risks and benefits. 62
22782153 2012
2
Natural selection in neoplastic progression of Barrett's esophagus. 62
16043360 2005
3
Assessment of cell surface glycoconjugates in normal, benign and malignant human nasal mucosa. 62
9532636 1997

Variations for Pre-Malignant Neoplasm

Expression for Pre-Malignant Neoplasm

Search GEO for disease gene expression data for Pre-Malignant Neoplasm.

Pathways for Pre-Malignant Neoplasm

Pathways related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 TP53 H2AC18 ESR1 ERBB2 EGFR EGF
2
Show member pathways
13.64 TP53 ESR1 ERBB2 EGFR EGF CDKN2A
3 12.76 PGR ESR1 ERBB2 EGFR EGF
4 12.58 TP53 EGFR EGF CDKN2A CDH1 BRCA1
5
Show member pathways
12.53 TP53 ERBB2 EGFR EGF CDKN2A CDH1
6
Show member pathways
12.41 CDH1 EGF EGFR ERBB2 TP53
7
Show member pathways
12.39 TP53 ESR1 ERBB2 CDH1
8
Show member pathways
12.29 PGR ESR1 CDKN2A BRCA1
9
Show member pathways
12.22 ESR1 ERBB2 EGFR EGF
10 12.09 TP53 EGFR EGF CDH1
11
Show member pathways
11.99 TP53 PGR ESR1 ERBB2 EGFR EGF
12
Show member pathways
11.95 PGR ESR1 ERBB2 EGFR EGF
13 11.88 TP53 ESR1 EGFR CYP19A1 CDH1 BRCA2
14
Show member pathways
11.83 TP53 CDKN2A BRCA2 BRCA1
15
Show member pathways
11.78 ESR1 ERBB2 EGFR
16
Show member pathways
11.75 TP53 BRCA2 BRCA1
17 11.73 TP53 BRCA2 BRCA1
18 11.69 TP53 KRT5 KRT14
19 11.64 TP53 ERBB2 EGFR CDKN2A
20 11.63 CDKN2A ESR1 TP53
21 11.62 ESR1 EGFR EGF
22 11.59 PGR ESR1 BRCA1
23 11.56 TP53 ERBB2 BRCA1
24 11.44 EGFR EGF CDH1
25 11.43 KRT5 KRT14 CDKN2A BRCA2
26 11.36 EGFR EGF CDH1
27 11.28 ESR1 CDKN2A BRCA2
28 11.27 CDH1 EGF EGFR ERBB2
29 11.13 PGR ESR1 ERBB2 EGFR
30 10.7 TP53 ERBB2 EGFR EGF CDKN2A CDH1
31 10.67 PGR ESR1 ERBB2 EGF
32 10.64 EGFR CYP19A1
33 10.63 TP53 CDH1
34 10.17 ESR1 CYP19A1

GO Terms for Pre-Malignant Neoplasm

Cellular components related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear ubiquitin ligase complex GO:0000152 8.92 BRCA2 BRCA1

Biological processes related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-templated transcription GO:0045893 10.03 BRCA1 BRCA2 CDH1 CDKN2A EGF EGFR
2 cellular response to ionizing radiation GO:0071479 9.73 TP53 BRCA2 BRCA1
3 positive regulation of gene expression GO:0010628 9.7 TP53 PGR MIR140 ERBB2 EGF CDKN2A
4 cellular response to indole-3-methanol GO:0071681 9.67 CDH1 BRCA1
5 positive regulation of RNA polymerase II transcription preinitiation complex assembly GO:0045899 9.62 TP53 ESR1
6 chordate embryonic development GO:0043009 9.61 BRCA2 BRCA1
7 negative regulation of immature T cell proliferation in thymus GO:0033088 9.58 ERBB2 CDKN2A
8 ERBB2-EGFR signaling pathway GO:0038134 9.1 ERBB2 EGFR EGF

Molecular functions related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA base-pairing translational repressor activity GO:1903231 8.92 MIR423 MIR342 MIR140 MIR139

Sources for Pre-Malignant Neoplasm

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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