MCID: PRM023
MIFTS: 28

Pre-Malignant Neoplasm

Categories: Cancer diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Pre-Malignant Neoplasm

MalaCards integrated aliases for Pre-Malignant Neoplasm:

Name: Pre-Malignant Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060071

Summaries for Pre-Malignant Neoplasm

Disease Ontology : 12 A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer.

MalaCards based summary : Pre-Malignant Neoplasm is related to conjunctival intraepithelial neoplasm and bartholin's gland adenoid cystic carcinoma. An important gene associated with Pre-Malignant Neoplasm is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Related phenotypes are digestive/alimentary and embryo

Related Diseases for Pre-Malignant Neoplasm

Diseases in the in Situ Carcinoma family:

Pre-Malignant Neoplasm Eye Carcinoma in Situ

Diseases related to Pre-Malignant Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 474)
# Related Disease Score Top Affiliating Genes
1 conjunctival intraepithelial neoplasm 11.1
2 bartholin's gland adenoid cystic carcinoma 10.6 PGR ESR1
3 uterine corpus adenosarcoma 10.6 PGR ESR1
4 chronic tympanitis 10.6 PGR ESR1
5 glassy cell carcinoma of the cervix 10.6 PGR ESR1 ERBB2
6 breast intraductal papillomatosis 10.6 PGR ESR1 ERBB2
7 nipple carcinoma 10.6 PGR ESR1 ERBB2
8 bartholin's gland adenoma 10.6 TP53 PGR ESR1
9 bartholin's gland benign neoplasm 10.6 TP53 PGR ESR1
10 vestibular gland benign neoplasm 10.6 TP53 PGR ESR1
11 oncocytic breast carcinoma 10.6 PGR ESR1 ERBB2
12 granulomatous endometritis 10.6 PGR ESR1
13 vulvar syringoma 10.6 PGR ESR1
14 fallopian tube clear cell adenocarcinoma 10.6 BRCA2 BRCA1
15 mucoepidermoid esophageal carcinoma 10.6 TP53 KRT5
16 apocrine adenosis of breast 10.6 TP53 PGR ERBB2
17 breast adenoid cystic carcinoma 10.6 PGR ESR1 ERBB2
18 scirrhous adenocarcinoma 10.6 PGR ERBB2 CDH1
19 lipid-rich breast carcinoma 10.6 PGR KRT5 ERBB2
20 breast squamous cell carcinoma 10.6 KRT5 ESR1 ERBB2
21 progesterone-receptor positive breast cancer 10.6 PGR ESR1 ERBB2
22 cervical adenosarcoma 10.5 TP53 PGR ESR1
23 breast mucinous carcinoma 10.5 PGR KRT5 ERBB2
24 lung leiomyoma 10.5 PGR ESR1
25 gastric papillary adenocarcinoma 10.5 TP53 ERBB2
26 gastric diffuse adenocarcinoma 10.5 PGR ERBB2 CDH1
27 retinitis pigmentosa 47 10.5 PGR ESR1 ERBB2
28 linitis plastica 10.5 PGR ERBB2 CDH1
29 parotid gland adenoid cystic carcinoma 10.5 ERBB2 CDKN2A
30 breast cystic hypersecretory carcinoma 10.5 KRT5 ERBB2 CDH1
31 penile urethral cancer 10.5 KRT5 CDKN2A
32 adult type testicular granulosa cell tumor 10.5 PGR ESR1
33 triple-receptor negative breast cancer 10.5 PGR ERBB2 BRCA2
34 cervical clear cell adenocarcinoma 10.5 PGR ESR1
35 familial ovarian cancer 10.5 ESR1 BRCA2 BRCA1
36 biphasic synovial sarcoma 10.5 PGR ESR1 CDH1
37 benign breast adenomyoepithelioma 10.5 KRT5 ESR1 EGFR
38 ovary transitional cell carcinoma 10.5 BRCA2 BRCA1
39 endosalpingiosis 10.5 PGR BRCA2 BRCA1
40 comedo carcinoma 10.5 TP53 PGR ESR1 ERBB2
41 mature teratoma 10.5 TP53 H2AC18 ERBB2
42 pregnancy adenoma 10.5 PGR KRT5
43 cancerophobia 10.5 BRCA2 BRCA1
44 external ear carcinoma 10.5 PGR KRT5
45 endometrial squamous cell carcinoma 10.5 PGR CDKN2A
46 breast papillary carcinoma 10.5 PGR KRT5 ESR1 ERBB2
47 mutagen sensitivity 10.5 TP53 BRCA2 BRCA1
48 intracranial meningioma 10.5 PGR ESR1 CDKN2A
49 nosophobia 10.5 BRCA2 BRCA1
50 papillary carcinoma 10.5 PGR ESR1 ERBB2 CDH1

Graphical network of the top 20 diseases related to Pre-Malignant Neoplasm:



Diseases related to Pre-Malignant Neoplasm

Symptoms & Phenotypes for Pre-Malignant Neoplasm

MGI Mouse Phenotypes related to Pre-Malignant Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.97 BRCA1 BRCA2 CDH1 CDKN2A EGFR ERBB2
2 embryo MP:0005380 9.91 BRCA1 BRCA2 CDH1 CDKN2A EGFR ERBB2
3 integument MP:0010771 9.9 BRCA1 BRCA2 CDH1 CDKN2A EGFR ERBB2
4 limbs/digits/tail MP:0005371 9.56 BRCA1 BRCA2 EGFR ERBB2 ESR1 KRT5
5 neoplasm MP:0002006 9.28 BRCA1 BRCA2 CDH1 CDKN2A EGFR ERBB2

Drugs & Therapeutics for Pre-Malignant Neoplasm

Search Clinical Trials , NIH Clinical Center for Pre-Malignant Neoplasm

Genetic Tests for Pre-Malignant Neoplasm

Anatomical Context for Pre-Malignant Neoplasm

Publications for Pre-Malignant Neoplasm

Articles related to Pre-Malignant Neoplasm:

# Title Authors PMID Year
1
Chemoprevention for keratinocytic (pre)cancers: balancing the risks and benefits. 61
22782153 2012
2
Natural selection in neoplastic progression of Barrett's esophagus. 61
16043360 2005
3
Assessment of cell surface glycoconjugates in normal, benign and malignant human nasal mucosa. 61
9532636 1997

Variations for Pre-Malignant Neoplasm

Expression for Pre-Malignant Neoplasm

Search GEO for disease gene expression data for Pre-Malignant Neoplasm.

Pathways for Pre-Malignant Neoplasm

Pathways related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.72 TP53 ERBB2 EGFR CDKN2A CDH1 BRCA2
2 12.64 TP53 ESR1 ERBB2 EGFR CDKN2A CDH1
3
Show member pathways
12.36 TP53 ESR1 ERBB2 EGFR CDKN2A CDH1
4
Show member pathways
12.28 TP53 PGR ESR1 ERBB2 EGFR CDKN2A
5
Show member pathways
12.2 TP53 MIR181A1 MIR17 CDKN2A BRCA1
6 12.15 TP53 ESR1 ERBB2 EGFR
7
Show member pathways
12.07 PGR ESR1 CDKN2A BRCA1
8 11.92 TP53 ESR1 EGFR CDH1 BRCA2 BRCA1
9
Show member pathways
11.79 PGR ESR1 ERBB2 EGFR
10 11.77 TP53 MIR342 MIR181A1 MIR17 MIR143 ERBB2
11
Show member pathways
11.67 TP53 BRCA2 BRCA1
12 11.59 ERBB2 EGFR CDH1
13 11.58 TP53 ERBB2 EGFR
14 11.58 TP53 ERBB2 EGFR CDKN2A CDH1
15 11.57 TP53 ERBB2 CDKN2A BRCA1
16 11.54 TP53 ERBB2 BRCA1
17 11.39 TP53 EGFR CDKN2A
18 11.14 ERBB2 EGFR CDH1

GO Terms for Pre-Malignant Neoplasm

Cellular components related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.43 TP53 ESR1 EGFR CDKN2A BRCA2 BRCA1
2 extracellular space GO:0005615 9.28 SERPINA3 MIR654 MIR342 MIR181A1 MIR17 MIR143

Biological processes related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.81 MIR143 ESR1 ERBB2 EGFR
2 negative regulation of gene expression GO:0010629 9.72 TP53 PGR MIR181A1 MIR17 ESR1
3 double-strand break repair GO:0006302 9.7 TP53 BRCA2 BRCA1
4 positive regulation of transcription, DNA-templated GO:0045893 9.7 TP53 ESR1 EGFR CDKN2A CDH1 BRCA2
5 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.57 TP53 EGFR
6 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.56 TP53 ESR1
7 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.55 TP53 ESR1
8 intracellular steroid hormone receptor signaling pathway GO:0030518 9.54 PGR ESR1
9 negative regulation of ERBB signaling pathway GO:1901185 9.49 ERBB2 EGFR
10 negative regulation of interleukin-1 alpha production GO:0032690 9.48 MIR181A1 MIR142
11 cellular response to indole-3-methanol GO:0071681 9.46 CDH1 BRCA1
12 chordate embryonic development GO:0043009 9.43 BRCA2 BRCA1
13 positive regulation of cell cycle arrest GO:0071158 9.43 TP53 CDKN2A BRCA1
14 negative regulation of immature T cell proliferation in thymus GO:0033088 9.4 ERBB2 CDKN2A
15 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.37 MIR17 MIR143
16 gene silencing by miRNA GO:0035195 9.17 MIR654 MIR342 MIR181A1 MIR17 MIR143 MIR142
17 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.13 TP53 BRCA2 BRCA1

Molecular functions related to Pre-Malignant Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.81 TP53 PGR ESR1 ERBB2 EGFR CT45A10
2 enzyme binding GO:0019899 9.65 TP53 PGR ESR1 EGFR BRCA1
3 ATPase binding GO:0051117 9.58 PGR ESR1 EGFR
4 mRNA 3'-UTR binding GO:0003730 9.43 TP53 MIR181A1 MIR17 MIR143 MIR142 MIR139
5 MDM2/MDM4 family protein binding GO:0097371 9.37 TP53 CDKN2A
6 nitric-oxide synthase regulator activity GO:0030235 9.32 ESR1 EGFR
7 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.17 MIR654 MIR342 MIR181A1 MIR17 MIR143 MIR142

Sources for Pre-Malignant Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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