MCID: PRC019
MIFTS: 48

Precocious Puberty

Categories: Endocrine diseases, Genetic diseases, Metabolic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Precocious Puberty

MalaCards integrated aliases for Precocious Puberty:

Name: Precocious Puberty 20 36 29 6 70 32
Cryptogenic Sexual Precocity 70
Familial Precocious Puberty 20
Idiopathic Sexual Precocity 20
Puberty Precocious 54
Sexual Precocity 20

Classifications:



External Ids:

KEGG 36 H00937
ICD10 32 E30.1
UMLS 70 C0034013 C0271527

Summaries for Precocious Puberty

KEGG : 36 Precocious puberty has been classically defined as the onset of secondary sexual characteristics in girls younger than 8 years old and in boys younger than 9 and a half years old. Central precocious puberty (CEPREPU) refers to a gonadotropin-dependent type which results from premature activation of the hypothalamic-pituitary-gonadal axis (HPG). CEPREPU is much more frequent in girls than in boys (up to 20:1 ratio). Recently, kisspeptin receptor (KISS1R) and its ligand, kisspeptin, were revealed as major gatekeepers of puberty onset. Mutations of the KISS1R gene were described in patients with impaired pubertal development. On the other hand, it has been reported that heterozygous mutations of the LHCGR gene cause gonadotropin-independent precocious puberty in males, but have no detectable effects on prepubertal or postpubertal females.

MalaCards based summary : Precocious Puberty, also known as cryptogenic sexual precocity, is related to central precocious puberty and idiopathic central precocious puberty. An important gene associated with Precocious Puberty is LOC100507346 (Uncharacterized LOC100507346), and among its related pathways/superpathways are Calcium signaling pathway and Neuroactive ligand-receptor interaction. The drugs Megestrol acetate and Prolactin Release-Inhibiting Factors have been mentioned in the context of this disorder. Affiliated tissues include pituitary, ovary and pineal, and related phenotypes are endocrine/exocrine gland and integument

GARD : 20 Precocious puberty is when a person's sexual and physical traits develop and mature earlier than normal. Normal puberty typically begins between ages 10 and 14 for girls, and ages 12 and 16 for boys. The start of puberty depends on various factors such as family history, nutrition and gender. The cause of precocious puberty is not always known. Some cases of precocious puberty are due to conditions that cause changes in the body's release of hormones. Treatment involves medications that can stop the release of sexual hormones.

Wikipedia : 73 In medicine, precocious puberty is puberty occurring at an unusually early age. In most cases, the... more...

Related Diseases for Precocious Puberty

Diseases in the Precocious Puberty family:

Precocious Puberty, Central, 1 Precocious Puberty, Central, 2
Central Precocious Puberty Secondary Central Precocious Puberty
Rare Precocious Puberty

Diseases related to Precocious Puberty via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 474)
# Related Disease Score Top Affiliating Genes
1 central precocious puberty 32.6 MKRN3 KISS1R KISS1 GNRH1 GH1
2 idiopathic central precocious puberty 32.4 MKRN3 KISS1R KISS1
3 hypothalamic hamartomas 32.1 KISS1R KISS1 GNRH1
4 precocious puberty, male-limited 31.3 STON1-GTF2A1L MKRN3 LHCGR KISS1R KISS1 GNRH1
5 ovarian cyst 31.0 GNRH1 GNAS
6 hypogonadism 31.0 LHCGR KISS1R KISS1 GNRH1
7 hyperprolactinemia 30.7 GNRH1 GNAS GH1
8 leydig cell tumor 30.6 LHCGR GNRH1 GNAS CYP21A2
9 empty sella syndrome 30.5 GNRH1 GH1
10 hypothalamic disease 30.4 GNRH1 GH1
11 hypothyroidism 30.4 GNRH1 GNAS GH1 FSHR
12 estrogen excess 30.4 GNRH1 FSHR
13 polycystic ovary syndrome 30.4 GNRH1 GH1 FSHR CYP21A2
14 fibrous dysplasia/mccune-albright syndrome 30.4 GNAS GH1
15 prader-willi syndrome 30.4 MKRN3 LEPR GNRH1 GH1
16 hypogonadotropic hypogonadism 30.4 LHCGR LEPR KISS1R KISS1 GNRH1
17 leydig cell hypoplasia 30.3 STON1-GTF2A1L LHCGR
18 pituitary adenoma 30.3 GNRH1 GNAS GH1
19 adenoma 30.2 LHCGR GNAS GH1 CYP21A2
20 pituitary tumors 30.2 GNAS GH1
21 amenorrhea 30.2 LHCGR GNRH1 FSHR
22 46 xx gonadal dysgenesis 30.2 LHCGR FSHR
23 pituitary gland disease 30.1 GNRH1 GNAS GH1
24 temple syndrome 30.1 MKRN3 KISS1 GNAS
25 craniopharyngioma 30.1 PTCH1 LEPR GNRH1 GH1
26 overgrowth syndrome 30.0 PTCH1 LOC100507346
27 pseudohermaphroditism 30.0 STON1-GTF2A1L LHCGR FSHR CYP21A2
28 pseudohypoparathyroidism, type ia 30.0 GNAS GH1
29 luteoma 30.0 FSHR CYP21A2
30 hyperinsulinism 30.0 LEPR GNRH1 GH1
31 normosmic congenital hypogonadotropic hypogonadism 29.9 KISS1R KISS1 GNRH1
32 pituitary adenoma, prolactin-secreting 29.8 GNRH1 GNAS GH1
33 cryptorchidism, unilateral or bilateral 29.7 MKRN3 LHCGR KISS1R KISS1 GNRH1 FSHR
34 anovulation 29.6 KISS1 GNRH1 FSHR CYP21A2
35 conn's syndrome 29.5 LHCGR GNRH1 GNAS GH1 CYP21A2
36 congenital hydrocephalus 29.5 PTCH1 LOC100507346
37 body mass index quantitative trait locus 11 29.5 LEPR GNAS GH1 FSHR CYP21A2
38 acromegaly 29.4 LEPR GNRH1 GNAS GH1
39 premature menopause 29.3 LHCGR KISS1R KISS1 GNRH1 FSHR CYP21A2
40 infertility 29.1 LHCGR LEPR KISS1 GNRH1 FSHR CYP21A2
41 kallmann syndrome 28.8 MKRN3 LEPR KISS1R KISS1 GNRH1 FSHR
42 precocious puberty, central, 2 11.8
43 precocious puberty, central, 1 11.8
44 mccune-albright syndrome 11.7
45 spastic paraplegia with precocious puberty 11.6
46 precocious puberty, gonadotropin-dependent 11.4
47 aromatase excess syndrome 11.3
48 precocious puberty in female 11.2
49 rare peripheral precocious puberty 11.2
50 rare precocious puberty 11.2

Graphical network of the top 20 diseases related to Precocious Puberty:



Diseases related to Precocious Puberty

Symptoms & Phenotypes for Precocious Puberty

MGI Mouse Phenotypes related to Precocious Puberty:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.97 FSHR GNAS GNRH1 KISS1 KISS1R LEPR
2 integument MP:0010771 9.92 CYP21A2 FSHR GNAS GNRH1 KISS1 KISS1R
3 adipose tissue MP:0005375 9.91 FSHR GNAS KISS1 KISS1R LEPR LHCGR
4 digestive/alimentary MP:0005381 9.88 GNRH1 KISS1 KISS1R LEPR LHCGR PTCH1
5 liver/biliary system MP:0005370 9.73 GNAS GNRH1 KISS1 KISS1R LEPR LHCGR
6 neoplasm MP:0002006 9.55 FSHR GNAS GNRH1 LEPR PTCH1
7 renal/urinary system MP:0005367 9.5 GNAS GNRH1 KISS1 KISS1R LEPR LHCGR
8 reproductive system MP:0005389 9.17 FSHR GNRH1 KISS1 KISS1R LEPR LHCGR

Drugs & Therapeutics for Precocious Puberty

Drugs for Precocious Puberty (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Megestrol acetate Approved, Investigational, Vet_approved Phase 4 595-33-5 11683
2 Prolactin Release-Inhibiting Factors Phase 4
3 Contraceptive Agents Phase 4
4 Central Nervous System Stimulants Phase 4
5
Megestrol Phase 4 3562-63-8 19090 3080587
6 Contraceptives, Oral Phase 4
7 Pharmaceutical Solutions Phase 3
8 Triptorelin Pamoate Phase 3
9
Testosterone Approved, Investigational Phase 2 58-22-0 6013
10
Bicalutamide Approved Phase 2 90357-06-5 56069 2375
11
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
12
Testolactone Approved, Investigational Phase 2 968-93-4 13769
13
Spironolactone Approved Phase 2 1952-01-7, 52-01-7 5833
14
Fulvestrant Approved, Investigational Phase 2 129453-61-8 104741 17756771
15
Deslorelin Investigational, Vet_approved Phase 2 57773-65-6
16 Hormone Antagonists Phase 2
17 Aromatase Inhibitors Phase 2
18 Androgen Antagonists Phase 2
19 Mineralocorticoid Receptor Antagonists Phase 2
20 Diuretics, Potassium Sparing Phase 2
21 Mineralocorticoids Phase 2
22 diuretics Phase 2
23 Estrogen Receptor Antagonists Phase 2
24 Estrogen Antagonists Phase 2
25 Estrogens Phase 2
26
Letrozole Approved, Investigational Phase 1 112809-51-5 3902
27
Ganirelix Approved Early Phase 1 124904-93-4, 123246-29-7 25081094
28
Epinephrine Approved, Vet_approved 51-43-4 5816
29
Racepinephrine Approved 329-65-7 838
30
Leuprolide Approved, Investigational 53714-56-0 3911 657181
31
Metformin Approved 657-24-9 14219 4091
32 Liver Extracts
33 Tin Fluorides
34 Follicle Stimulating Hormone Early Phase 1
35 Tea
36 Androgens
37 Epinephryl borate
38 Antineoplastic Agents, Hormonal
39 Hormones
40 Hypoglycemic Agents

Interventional clinical trials:

(show all 49)
# Name Status NCT ID Phase Drugs
1 Analysis of Genetic and Environmental Parameters Influencing Growth Rate of Precocious Puberty Children Unknown status NCT00438217 Phase 4 Triptorelin (GnRH agonists);Leuprolide (GnRH agonists)
2 Analysis of Body Mass Index in Central Precocious Puberty(CPP) Patients Treated With Leuprolide Acetate Unknown status NCT02974270 Phase 4 Leuprolide
3 An Open Label, Multicenter Study to Assess the Safety and Efficacy of Leuprorelin in the Treatment of Central Precocious Puberty Completed NCT02427958 Phase 4 Leuprorelin
4 The Phase 4 Clinical Trial to Evaluate the Efficacy and Safety of Luphere Depot Inj. 3.75mg(Leuprolide Acetate 3.75mg) in Patients With Precocious Puberty; A Single, Open, Multi-center, Prospective Study Completed NCT01634321 Phase 4 Luphere depot 3.75mg(Leuprolide acetate 3.75mg)
5 A Multicenter, Open, Prospective Study to Evaluate the Safety and Efficacy of Leuprorelin Acetate DPS (Leuplin DPS) Treatment Quarterly in Patients With Central Precocious Puberty Completed NCT03316482 Phase 4 Leuplin DPS 11.25mg
6 Multi-site Study of Comprehensive Treatment for Children Precocious Puberty Completed NCT02920515 Phase 4 Triptorlin or Leuprorelin;Zhibo dihuang pills;Dabu ying pills
7 Understanding Experimentally Induced Hot Flushes and Their Impact on Sleep and Mood Completed NCT00455689 Phase 4 Leuprolide acetate
8 Evidence-based Medical Research on the Treatment of Children's Rapid Progressive Central Precocious Puberty With Integrative Chinese and Western Medicine Recruiting NCT03963752 Phase 4 Ziyinxiehuo Granules Herbs;Megestrol Acetate Tablet;Leuprorelin Acetate 3.75mg Injection
9 Triptorelin Acetate Utilization for the Early Diagnosis of Central Precocious Puberty (CPP) in Girls. Completed NCT01278290 Phase 3
10 Phase III, Open-Label Study to Evaluate Efficacy and Safety of Histrelin Subdermal Implant in Children With Central Precocious Puberty Completed NCT00779103 Phase 3 Histrelin Subcutaneous Implant
11 A Phase 3, Randomized, Multi-Center, Open-Label Study to Evaluate the Efficacy and Safety of Leuprolide Acetate 11.25 and 30 mg Formulations in Children With Central Precocious Puberty Completed NCT00635817 Phase 3 Leuprolide acetate 11.25 mg;Leuprolide acetate 30 mg
12 Study of Lupron Depot In The Treatment of Central Precocious Puberty Completed NCT00660010 Phase 3 Lupron (leuprolide acetate)
13 An Open-label, Non-comparative, Multicenter Study on the Efficacy, Safety, and Pharmacokinetics of Triptorelin Pamoate (Embonate) 22.5 mg 6-month Formulation in Patients Suffering From Central (Gonadotropin-dependent) Precocious Puberty Completed NCT01467882 Phase 3 Triptorelin
14 Follow-up of the Phase III, Multicentre, Non Comparative, One Single Group, Open Study to Assess the Long-term Efficacy and Tolerability of Pamoate of Triptorelin 11.25 mg in Children With Precocious Puberty Completed NCT00909844 Phase 3 Triptorelin (I.N.N.)
15 Phase III, Multicentre, Non-comparative, Open and Single Stage Study to Assess the Efficacy and Safety of Pamoate of Triptorelin 11.25 MG in Children With Precocious Puberty Completed NCT00564850 Phase 3 Triptorelin pamoate 11.25mg (Decapeptyl® SR)
16 An Open-label, Single Arm, Multicenter Study on the Efficacy, Safety, and Pharmacokinetics of Leuprolide Acetate 45 mg for Injectable Suspension Controlled Release in Subjects With Central (Gonadotropin-Dependent) Precocious Puberty Completed NCT02452931 Phase 3 Leuprolide Acetate 45 mg
17 A 36 Month, Multi-Center, Open-Label Extension Study to Evaluate the Safety of Leuprolide Acetate 11.25 mg and 30 mg Formulations in Children With Central Precocious Puberty Completed NCT00667446 Phase 3 Leuprolide Acetate 3 Month Depot
18 A Phase 3, Multicenter, Open-Label, Two-Part Study to Evaluate the Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of Leuprolide Acetate 45mg 6-Month Depot Formulation in Children With Central Precocious Puberty (CPP) Active, not recruiting NCT03695237 Phase 3 Leuprolide Acetate (LA)
19 An Open-label, Multicentre, Single Arm Study to Assess the Efficacy and Safety of Triptorelin 3-month Formulation in Chinese Children With Central Precocious Puberty Not yet recruiting NCT04736602 Phase 3 Triptorelin pamoate 15mg
20 An Open-label, Non-comparative, Multi-centre Study to Assess the Efficacy and Safety of Bicalutamide When Used in Combination With Anastrozole for the Treatment of Gonadotropin-independent Precocious Puberty in Boys With Testotoxicosis Completed NCT00094328 Phase 2 Bicalutamide;Anastrozole
21 Spironolactone and Testolactone Treatment of Boys With Familial Isosexual Precocious Puberty Completed NCT00001202 Phase 2 Spironolactone;Testolactone;Deslorelin
22 Testolactone Treatment of Girls With LHRH Analog-Resistant Precocious Puberty Due to Autonomous, Non-Neoplastic Ovarian Estrogen Secretion Completed NCT00001181 Phase 2 Testolactone
23 An Open-label Study Evaluating the Safety and Efficacy of Anastrozole™ (ARIMIDEX) in the Treatment of Precocious Puberty in Girls With McCune-Albright Syndrome Completed NCT00055302 Phase 2 Arimidex 1 mg
24 An Open-label, Non-Comparative Trial to Evaluate the Safety, Efficacy and Pharmacokinetics of Faslodex (Fulvestrant) in Girls With Progressive Precocious Puberty Associated With McCune-Albright Syndrome Active, not recruiting NCT00278915 Phase 2 Fulvestrant
25 Effects of the Aromatase Inhibitor Letrozole on Pubertal Progression and Indices of Bone Turnover in Girls With Precocious Puberty and McCune-Albright Syndrome (MAS) Completed NCT00006174 Phase 1 Letrozole
26 Urinary LH in the Diagnosis of Precocious Puberty Unknown status NCT01800565
27 Influence of Early Adiposity Rebound, Genetic Polymorphisms and GnRHa Treatment on Long-term Outcome of Girls With Idiopathic Central Precocious Puberty. Unknown status NCT02790112
28 LH Response to GnRH Test in Prepubescent Girls Under 6 Years Unknown status NCT01944488 GnRH agonist
29 Follow-up of Girls With Premature Thelarche and Precocious Puberty: a Clinical and Paraclinical Study of Girls With Thelarche and Healthy Controls Unknown status NCT01944475
30 Purification of Testis-Stimulating Factor in Precocious Puberty Completed NCT00004344 leuprolide;testosterone
31 Study of Gonadotropin-Releasing Hormone Pulse Frequency in Sexual Maturation and in the Menstrual Cycle Completed NCT00004335
32 Effect of a GnRH Injection on Ghrelin Concentrations in Girls With Suspected Precocious Puberty Completed NCT02431416 Gonadotropin releasing hormone (GnRH);Sodium Chloride
33 Efficacy of Experienced Chinese Herbal Formulas for the Treatment of Different Types of Precocious Puberty: A Single-blinded Randomized Controlled Trial Completed NCT02650141 ziyinxiehuo Granules;zishenqinggan Granules
34 The Effect of Medical Clown on the Pain and Anxiety Perception During LRH Analog Treatment or Growth Hormone Provocation Test Completed NCT02199587
35 An Observational, Retrospective Study to Evaluate the Long Term Safety and Effectiveness of Leuprorelin in the Treatment of Central Precocious Puberty Completed NCT02993926 Enantone;GnRH agonist
36 Polymorphisms in the Kisspeptin/GPR54 Pathway Genes and the Risk of Early Puberty Completed NCT04012632
37 Qualitative Assessment of the Psychosocial Impact of Early Puberty in Girls Aged 6 to 8 Years Completed NCT01679925
38 Follicle-Stimulating Hormone (FSH) and the Onset of Puberty Completed NCT00734279 Early Phase 1 Leuprolide Acetate - Early Puberty Leuprolide Visit;Ganirelix - Early Puberty Ganirelix Visit;Ganirelix - Delayed Puberty Ganirelix Visit;Leuprolide Acetate- Delayed Puberty Leuprolide Visit
39 Polymorphisms in Obesity-related Genes Are Associated With Risk of Early Puberty in Han Chinese Girls Completed NCT04317014
40 The Effect of Childhood Overweight and Obesity and Genetic Factors on Puberty Development: a Prospective Cohort Study Recruiting NCT04113070
41 Molecular Basis of Inherited Reproductive Disorders Recruiting NCT00494169
42 The Genetics of Neuroendocrine Reproductive Disorders and of the Cleft Lip and/or Palate Recruiting NCT01601171
43 The Effect of Decaffeinated Green Tea Polyphenol Intake on the Risk of Precocious Puberty Among Obese Girls Active, not recruiting NCT03628937
44 Natural History Study of Patients With Excess Androgen Enrolling by invitation NCT00250159
45 Effect of Prevalence of Overweight and Obesity(Body Mass Index (BMI)) on Efficacy of Herbal Medicines(ZiYinXieHuo) in Girls' Sexual Precocity Not yet recruiting NCT04665713
46 Evaluation of the Correlation Between Psychological Intervention, Including Providing Knowledge and Tools for Problems Solving, and the Anxiety Level of Female Patients Arriving to ACTH LRH Test - Pilot Study Not yet recruiting NCT04502836
47 THE EFFICACY OF PREOPERATIVE USAGE OF GONADOTROPINE-RELEASING HORMONE AGONIST IN PATIENTS UNDERGOING TOTAL LAPAROSCOPIC HYSTERECTOMY DUE TO UTERIN FIBROIDS Not yet recruiting NCT04192812 PREOPERATİVE GnRHa THERAPY (LEUPROLIDE ACETATE) BEFORE SURGERY FOR UTERİN FIBROIDS;NO GnRHa
48 Markers of Adequate Pubertal Suppression During Supprelin LA Therapy for Central Precocious Puberty Terminated NCT02006680
49 A Double Blind Randomized Controlled 12 Month Trial of Metformin for the Treatment of Premature Pubarche in Girls Terminated NCT01316042 sugar pill;Metformin, glucophage

Search NIH Clinical Center for Precocious Puberty

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Gonadorelin
Gonadorelin Acetate
Gonadorelin Hydrochloride
Leuprolide
Leuprolide Acetate
Nafarelin
Nafarelin Acetate
Tamoxifen
Tamoxifen Citrate

Genetic Tests for Precocious Puberty

Genetic tests related to Precocious Puberty:

# Genetic test Affiliating Genes
1 Precocious Puberty 29

Anatomical Context for Precocious Puberty

MalaCards organs/tissues related to Precocious Puberty:

40
Pituitary, Ovary, Pineal, Testis, Hypothalamus, Bone, Brain

Publications for Precocious Puberty

Articles related to Precocious Puberty:

(show top 50) (show all 4310)
# Title Authors PMID Year
1
Central precocious puberty due to hypothalamic hamartomas correlates with anatomic features but not with expression of GnRH, TGFalpha, or KISS1. 54 61
20389100 2010
2
Thyroid autoimmunity and miscarriages: the corpus luteum hypothesis. 54 61
19505771 2009
3
No activating mutations of FSH receptor in four children with ovarian juvenile granulosa cell tumors and the association of these tumors with central precocious puberty. 54 61
19539204 2009
4
[Advances on related genes with sexual precocity in mammals]. 61 54
19138897 2009
5
Body mass index and body composition in adolescents treated with gonadotropin-releasing hormone analogue triptorelin depot for central precocious puberty: data at near final height. 61 54
19176945 2009
6
A case of X-linked adrenal hypoplasia congenita, central precocious puberty and absence of the DAX-1 gene: implications for pubertal regulation. 54 61
19339795 2009
7
ACTH-dependent precocious pseudopuberty in an infant with DAX1 gene mutation. 61 54
18414894 2009
8
Subcutaneous gonadotropin-releasing hormone agonist (triptorelin) test for diagnosing precocious puberty. 61 54
19690429 2009
9
Effectiveness of anastrozole and cyproterone acetate in two brothers with familial male precocious puberty. 61 54
19209621 2008
10
[Relationship of plasma ghrelin and adenohypophyseal hormone levels in female precocious puberty]. 54 61
18925720 2008
11
A 46XX disorder of sex development with a prostate gland and increased level of prostate-specific antigen. 61 54
18300543 2008
12
Diversity of actions of GnRHs mediated by ligand-induced selective signaling. 61 54
17976709 2008
13
Predictive factors for organic central precocious puberty and utility of simplified gonadotropin-releasing hormone tests. 54 61
18045276 2007
14
Leuprolide acetate: a drug of diverse clinical applications. 61 54
17970643 2007
15
Luteinizing hormone (LH) and estradiol suppression and growth in girls with central precocious puberty: is more suppression better? Are pre-injection LH levels useful in monitoring treatment? 61 54
18183790 2007
16
Early maturation of gonadotropin-releasing hormone secretion and sexual precocity after exposure of infant female rats to estradiol or dichlorodiphenyltrichloroethane. 54 61
17596564 2007
17
Serum sex hormone-binding globulin levels in healthy children and girls with precocious puberty before and during gonadotropin-releasing hormone agonist treatment. 61 54
17519314 2007
18
Efficacy of combined treatment with growth hormone and gonadotropin releasing hormone analogue in children with poor prognosis of adult height. 54 61
17684302 2007
19
Association study of the polymorphisms in the KISS1 gene with central precocious puberty in Chinese girls. 61 54
17609410 2007
20
Regulation of circulating leptin and its soluble receptor during pubertal development in the male rhesus monkey (Macaca mulatta). 61 54
17873322 2007
21
Insights learned from L457(3.43)R, an activating mutant of the human lutropin receptor. 54 61
17055147 2007
22
Unexpected mosaicism of R201H-GNAS1 mutant-bearing cells in the testes underlie macro-orchidism without sexual precocity in McCune-Albright syndrome. 54 61
17101633 2006
23
Recurrent anaphylaxis associated with gonadotropin-releasing hormone analogs: case report and review of the literature. 54 61
17125443 2006
24
A constitutively active mutant of the human lutropin receptor (hLHR-L457R) escapes lysosomal targeting and degradation. 61 54
16803865 2006
25
A single somatic activating Asp578His mutation of the luteinizing hormone receptor causes Leydig cell tumour in boys with gonadotropin-independent precocious puberty. 61 54
16918965 2006
26
Variable presentation of precocious puberty associated with the D564G mutation of the LHCGR gene in children with testotoxicosis. 61 54
16887451 2006
27
Management of short stature with GnRH agonist and co-treatment with growth hormone: a controversial issue. 61 54
16787697 2006
28
Long-term GnRH agonist treatment for female central precocious puberty does not impair reproductive function. 54 61
16757104 2006
29
Ultrasonographic and clinical parameters for early differentiation between precocious puberty and premature thelarche. 54 61
16728550 2006
30
McCune-Albright syndrome: growth hormone and prolactin hypersecretion. 54 61
16789626 2006
31
Congenital adrenal hyperplasia in the Bahamas due to 21-hydroxylase deficiency. 61 54
16921705 2006
32
Gonadotropin-releasing hormone analog therapy for central precocious puberty and other childhood disorders affecting growth and puberty. 54 61
17002488 2006
33
Control of puberty by excitatory amino acid neurotransmitters and its clinical implications. 54 61
16388117 2005
34
The histrelin implant: a novel treatment for central precocious puberty. 61 54
16322137 2005
35
Prolactin secretion before, during, and after chronic gonadotropin-releasing hormone agonist treatments in children. 61 54
16169408 2005
36
New developments in the use of peptide gonadotropin-releasing hormone antagonists versus agonists. 54 61
16144493 2005
37
Leptin changes in Taiwanese girls with central precocious puberty before and during the GnRH agonist treatment. 54 61
16640001 2005
38
The gonadotrophins response to GnRH test is not a predictor of neurological lesion in girls with central precocious puberty. 54 61
16279361 2005
39
Antagonistic and agonistic GnRH analogue treatment of precocious puberty: tracking gonadotropin concentrations in urine. 61 54
15995342 2005
40
Gonadotropin-releasing hormone analogue treatment for precocious puberty. Twenty years of experience. 61 54
15722620 2005
41
Non-peptidic GnRH receptor antagonists. 54 61
15544487 2004
42
[Simplified gonadorelin stimulation test in diagnosis of precocious puberty]. 61 54
15476332 2004
43
Activating GNAS1 gene mutations in patients with premature thelarche. 61 54
15289771 2004
44
[Clinical application of simplified gonadotropin releasing hormone stimulating test in management of female isosexual precocious puberty]. 54 61
15312320 2004
45
Aromatase inhibitors in precocious puberty: rationale and experience to date. 61 54
16026110 2004
46
Clinical and molecular analysis of human reproductive disorders in Brazilian patients. 61 54
14689055 2004
47
Lack of efficacy of fadrozole in treating precocious puberty in girls with the McCune-Albright syndrome. 54 61
14671160 2003
48
Quantitative calcaneal ultrasound parameters and bone mineral density at final height in girls treated with depot gonadotrophin-releasing hormone agonist for central precocious puberty or idiopathic short stature. 61 54
13680381 2003
49
Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 in girls with premature thelarche. 54 61
12948294 2003
50
Final adult height in "early normal pubertal girls" treated with gonadotropin releasing hormone agonists. 61 54
12929985 2003

Variations for Precocious Puberty

ClinVar genetic disease variations for Precocious Puberty:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 PTCH1 , LOC100507346 NM_000264.5(PTCH1):c.2265_2268del (p.Leu756fs) Deletion Pathogenic 997831 GRCh37: 9:98229690-98229693
GRCh38: 9:95467408-95467411

Expression for Precocious Puberty

Search GEO for disease gene expression data for Precocious Puberty.

Pathways for Precocious Puberty

Pathways related to Precocious Puberty according to KEGG:

36
# Name Kegg Source Accession
1 Calcium signaling pathway hsa04020
2 Neuroactive ligand-receptor interaction hsa04080
3 GnRH signaling pathway hsa04912

GO Terms for Precocious Puberty

Biological processes related to Precocious Puberty according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.87 PTCH1 LHCGR KISS1R GNRH1 GNAS GH1
2 G protein-coupled receptor signaling pathway GO:0007186 9.63 LHCGR KISS1R KISS1 GNRH1 GNAS FSHR
3 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.54 LHCGR GNAS FSHR
4 energy reserve metabolic process GO:0006112 9.4 LEPR GNAS
5 negative regulation of multicellular organism growth GO:0040015 9.26 PTCH1 GNAS
6 ovulation cycle process GO:0022602 8.96 LHCGR FSHR
7 activation of adenylate cyclase activity GO:0007190 8.8 LHCGR GNAS FSHR

Molecular functions related to Precocious Puberty according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-hormone receptor activity GO:0016500 8.96 LHCGR FSHR
2 G protein-coupled peptide receptor activity GO:0008528 8.8 LHCGR KISS1R FSHR

Sources for Precocious Puberty

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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