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MCID: PRC019
MIFTS: 52

Precocious Puberty

Categories: Rare diseases, Endocrine diseases, Genetic diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Precocious Puberty

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MalaCards integrated aliases for Precocious Puberty:

Name: Precocious Puberty 53 37 29 73
Cryptogenic Sexual Precocity 73
Familial Precocious Puberty 53
Idiopathic Sexual Precocity 53
Puberty Precocious 55
Sexual Precocity 53

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Endocrine diseases Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

KEGG 37 H00937
ICD10 33 E30.1
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Summaries for Precocious Puberty

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NIH Rare Diseases : 53 Precocious puberty is when a person's sexual and physical traits develop and mature earlier than normal. Normal puberty typically begins between ages 10 and 14 for girls, and ages 12 and 16 for boys. The start of puberty depends on various factors such as family history, nutrition and gender. The cause of precocious puberty is not always known. Some cases of precocious puberty are due to conditions that cause changes in the body's release of hormones. Treatment involves medications that can stop the release of sexual hormones.

MalaCards based summary : Precocious Puberty, also known as cryptogenic sexual precocity, is related to precocious puberty, male-limited and idiopathic central precocious puberty. An important gene associated with Precocious Puberty is LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor), and among its related pathways/superpathways are Calcium signaling pathway and Neuroactive ligand-receptor interaction. The drugs Leuprolide and Metformin have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and pituitary, and related phenotypes are adipose tissue and endocrine/exocrine gland

Wikipedia : 76 In medicine, precocious puberty is puberty occurring at an unusually early age. In most cases, the... more...

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Related Diseases for Precocious Puberty

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Diseases in the Precocious Puberty family:

Precocious Puberty, Central, 1 Precocious Puberty, Central, 2
Central Precocious Puberty Secondary Central Precocious Puberty

Diseases related to Precocious Puberty via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 210)
# Related Disease Score Top Affiliating Genes
1 precocious puberty, male-limited 34.1 CYP19A1 LHCGR
2 idiopathic central precocious puberty 33.3 KISS1 KISS1R MKRN3
3 central precocious puberty 33.2 GNRH1 KISS1 KISS1R MKRN3
4 testotoxicosis 32.5 CYP19A1 GNAS LHCGR
5 mccune-albright syndrome 32.1 CYP19A1 GH1 GNAS
6 hypothalamic hamartomas 32.0 GNRH1 KISS1 KISS1R
7 empty sella syndrome 30.5 GH1 GNRH1
8 hypothalamic disease 30.2 GH1 GNRH1
9 fibrous dysplasia 30.2 GH1 GNAS
10 craniopharyngioma 30.1 GH1 GNRH1
11 hyperprolactinemia 30.1 GH1 GNRH1
12 adrenal rest tumor 30.1 CYP21A2 GNRH1
13 hypogonadotropic hypogonadism 30.0 GNRH1 KISS1 KISS1R
14 prader-willi syndrome 29.9 GH1 GNRH1 MKRN3
15 amenorrhea 29.9 GNRH1 LHCGR
16 hypogonadotropism 29.8 GNRH1 KISS1 KISS1R
17 estrogen excess 29.7 CYP19A1 LHCGR
18 pseudohermaphroditism 29.6 CYP19A1 LHCGR
19 leydig cell tumor 29.4 CYP19A1 CYP21A2 LHCGR
20 lipoid congenital adrenal hyperplasia 29.3 CYP19A1 CYP21A2
21 hypogonadism 29.3 GNRH1 KISS1 KISS1R LHCGR
22 hyperandrogenism 29.3 CYP19A1 CYP21A2 GNRH1
23 polycystic ovary syndrome 29.3 CYP19A1 CYP21A2 GNRH1
24 adenoma 29.3 CYP21A2 GH1 GNAS LHCGR
25 infertility 29.0 CYP19A1 GNRH1 LHCGR
26 adrenocortical carcinoma, hereditary 28.6 CYP19A1 CYP21A2 GNAS
27 precocious puberty, central, 2 12.5
28 familial male-limited precocious puberty 12.5
29 precocious puberty, central, 1 12.5
30 spastic paraplegia with precocious puberty 12.3
31 secondary central precocious puberty 12.2
32 hypotonia, seizures, and precocious puberty 12.2
33 x-linked intellectual disability-precocious puberty-obesity syndrome 12.1
34 precocious puberty, gonadotropin-dependent 12.1
35 carpenter syndrome 1 11.1
36 adrenal hyperplasia, congenital, due to steroid 11-beta-hydroxylase deficiency 11.0
37 mental retardation, x-linked 102 11.0
38 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 11.0
39 pineal gland cancer 11.0
40 ovarian sex cord tumor with annular tubules 11.0
41 polyembryoma 11.0
42 pallister-hall syndrome 11.0
43 penis agenesis 10.5 GNRH1 LHCGR
44 aging 10.4
45 aromatase excess syndrome 10.4
46 body mass index quantitative trait locus 1 10.4
47 hypothyroidism 10.4
48 acth-independent macronodular adrenal hyperplasia 10.3 GNAS GNRH1
49 pseudohypoparathyroidism, type ia 10.3 GH1 GNAS
50 chromophobe adenoma 10.2 GH1 GNRH1

Graphical network of the top 20 diseases related to Precocious Puberty:



Diseases related to Precocious Puberty
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Symptoms & Phenotypes for Precocious Puberty

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MGI Mouse Phenotypes related to Precocious Puberty:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.77 KISS1 KISS1R LHCGR CYP19A1 GNAS
2 endocrine/exocrine gland MP:0005379 9.73 KISS1 KISS1R LHCGR CYP19A1 GNAS GNRH1
3 digestive/alimentary MP:0005381 9.72 KISS1 KISS1R LHCGR CYP19A1 GNRH1
4 integument MP:0010771 9.55 KISS1 KISS1R CYP19A1 GNAS GNRH1
5 liver/biliary system MP:0005370 9.43 KISS1 KISS1R LHCGR CYP19A1 GNAS GNRH1
6 renal/urinary system MP:0005367 9.1 KISS1R LHCGR CYP19A1 GNAS GNRH1 KISS1
Sources

Drugs & Therapeutics for Precocious Puberty

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Drugs for Precocious Puberty (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Leuprolide Approved, Investigational Phase 4,Phase 2,Phase 3,Early Phase 1 53714-56-0 3911 657181
2
Metformin Approved Phase 4 657-24-9 14219 4091
3 Deslorelin Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 57773-65-6
4 Triptorelin Pamoate Phase 4,Phase 3,Not Applicable
5 Fertility Agents Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable
6 Contraceptive Agents Phase 4,Phase 3,Not Applicable
7 Luteolytic Agents Phase 4,Phase 3,Not Applicable
8 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable
9 insulin Phase 4
10 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
11 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
13 Hypoglycemic Agents Phase 4
14 Insulin, Globin Zinc Phase 4
15 Pharmaceutical Solutions Phase 3,Phase 2
16
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
17
Spironolactone Approved Phase 2 1952-01-7, 52-01-7 5833
18
Testolactone Approved, Investigational Phase 2 968-93-4 13769
19
Testosterone Approved, Investigational Phase 2 58-22-0 6013
20
Bicalutamide Approved Phase 2 90357-06-5 56069 2375
21
Fulvestrant Approved, Investigational Phase 2 129453-61-8 104741 17756771
22 diuretics Phase 2
23 Mineralocorticoid Receptor Antagonists Phase 2
24 Mineralocorticoids Phase 2
25 Natriuretic Agents Phase 2
26 Steroid Synthesis Inhibitors Phase 2,Phase 1
27 Androgen Antagonists Phase 2
28 Androgens Phase 2,Phase 1,Not Applicable
29 Diuretics, Potassium Sparing Phase 2
30 Estrogen Antagonists Phase 2,Phase 1
31 Estrogens Phase 2,Phase 1
32 Prolactin Release-Inhibiting Factors Phase 2
33 Aromatase Inhibitors Phase 2,Phase 1
34 Bone Density Conservation Agents Phase 1, Phase 2
35 Calcium, Dietary Phase 1, Phase 2
36 Estrogen Receptor Antagonists Phase 2
37
Letrozole Approved, Investigational Phase 1 112809-51-5 3902
38
Oxandrolone Approved, Investigational Phase 1 53-39-4 5878
39 Anabolic Agents Phase 1
40
Zinc Approved, Investigational 7440-66-6 23994
41
Ganirelix Approved Early Phase 1 123246-29-7, 124904-93-4 25081094
42
Histamine Approved, Investigational 75614-87-8, 51-45-6 774
43
Dexamethasone Approved, Investigational, Vet_approved Not Applicable 50-02-2 5743
44
Epinephrine Approved, Vet_approved 51-43-4 5816
45
Menotropins Approved Not Applicable 61489-71-2, 9002-68-0 5360545
46
Racepinephrine Approved 329-65-7 838
47 Liver Extracts Not Applicable
48
Histamine Phosphate 51-74-1 65513
49 Follicle Stimulating Hormone Early Phase 1
50 Neurotransmitter Agents

Interventional clinical trials:

(show top 50) (show all 52)
# Name Status NCT ID Phase Drugs
1 Analysis of Genetic and Environmental Parameters Influencing Growth Rate of Precocious Puberty Children Unknown status NCT00438217 Phase 4 Triptorelin (GnRH agonists);Leuprolide (GnRH agonists)
2 Comparative Validation of the Triptorelin Test for the Diagnosis of CPP in Girls Unknown status NCT01278290 Phase 4 Triptorelin acetate and Gonadorelin acetate;Gonadorelin acetate and Triptorelin acetate
3 Study of Comprehensive Diagnosis and Treatment for Children Precocious Puberty Completed NCT02920515 Phase 4 Triptorlin or Leuprorelin;Zhibo dihuang pills;Dabu ying pills
4 The Clinical Trial to Evaluate the Efficacy and Safety of Luphere Depot Inj. 3.75mg(Leuprolide Acetate 3.75mg) in Patients With Precocious Puberty Completed NCT01634321 Phase 4 Luphere depot 3.75mg(Leuprolide acetate 3.75mg)
5 Leuprorelin Acetate DPS (Leuplin DPS) Treatment Quarterly in Patients With Central Precocious Puberty Recruiting NCT03316482 Phase 4 Leuplin DPS 11.25mg
6 Analysis of Body Mass Index in Central Precocious Puberty Patients Treated With Leuprolide Acetate Recruiting NCT02974270 Phase 4 Leuprolide
7 A Study to Assess the Safety and Efficacy of Leuprorelin in Central Precocious Puberty in Chinese Patients Active, not recruiting NCT02427958 Phase 4 Leuprorelin
8 A 4 Year Combination Therapy of Growth Hormone and (GnRH) Agonist in Children With a Short Predicted Height Active, not recruiting NCT00840944 Phase 4 somatropin;triptorelin
9 The Health Influences of Puberty (HIP) Study Active, not recruiting NCT01775813 Phase 4 Metformin
10 Understanding Experimentally Induced Hot Flushes Unknown status NCT00455689 Phase 2, Phase 3 Leuprolide acetate (Lupron)
11 Efficacy, Safety, and Pharmacokinetics (PK) of Triptorelin 6-month Formulation in Patients With Central Precocious Puberty Completed NCT01467882 Phase 3 Triptorelin
12 Histrelin Subcutaneous Implant in Children With Central Precocious Puberty Completed NCT00779103 Phase 3 Histrelin Subcutaneous Implant
13 Effects of Triptorelin Pamoate in Children With Precocious Puberty - Follow up Study Completed NCT00909844 Phase 3 Triptorelin (I.N.N.)
14 Efficacy and Safety Study of Pamoate of Triptorelin in Children With Precocious Puberty Completed NCT00564850 Phase 3 Triptorelin pamoate 11.25mg (Decapeptyl® SR)
15 Safety Extension Study Of Leuprolide Acetate (Lupron Depot) In The Treatment Of Central Precocious Puberty Completed NCT00667446 Phase 3 Leuprolide Acetate 3 Month Depot
16 Study of Lupron Depot In The Treatment of Central Precocious Puberty Completed NCT00660010 Phase 3 Lupron (leuprolide acetate)
17 A Study of Leuprolide 11.25 mg and 30 mg Administered Every 3 Months to Treat Central Precocious Puberty Completed NCT00635817 Phase 3 Leuprolide acetate 11.25 mg;Leuprolide acetate 30 mg
18 Pharmacokinetic Study of Leuprolide Acetate Injectable Suspension in the Treatment of Central Precocious Puberty Active, not recruiting NCT02452931 Phase 3 Leuprolide Acetate 45 mg
19 Severe Decrease of Growth Velocity in Children With Anorexia Nervosa.Therapeutic Trial of Growth Hormone Active, not recruiting NCT01626833 Phase 2, Phase 3 SOMATROPINE* : Norditropine® simplexx®
20 Treatment of Boys With Precocious Puberty Completed NCT00001202 Phase 2 Spironolactone;Testolactone;Deslorelin
21 Testolactone for the Treatment of Girls With LHRH Resistant Precocious Puberty Completed NCT00001181 Phase 2 Testolactone
22 Pediatrics Testotoxicosis Study [Bicalutamide Anastrozole Treatment for Testotoxicosis] Completed NCT00094328 Phase 2 Bicalutamide;Anastrozole
23 Encouraging Calcium Absorption and Bone Formation During Early Puberty Completed NCT00022867 Phase 1, Phase 2 Nondigestible oligosaccharide (NDO)
24 Arimidex in McCune Albright Syndrome Completed NCT00055302 Phase 2 Arimidex 1 mg
25 Study of Luteinizing Hormone-Releasing Hormone Analog (LHRHa) in Pubertal Patients With Extreme Short Stature Completed NCT00001190 Phase 2 Deslorelin
26 Faslodex in McCune Albright Syndrome Active, not recruiting NCT00278915 Phase 2 Fulvestrant
27 Effects of Letrozole on Precocious Puberty Due to McCune Albright Syndrome Completed NCT00006174 Phase 1 Letrozole
28 Pilot Study of the Safety and Efficacy of Oxandrolone in the Prevention and Treatment of Malnutrition in Infants Active, not recruiting NCT01048632 Phase 1 Oxandrolone
29 Markers of Pubertal Suppression During Therapy for Precocious Puberty Unknown status NCT02006680
30 First-Voided Urinary LH vs. GnRH-stimulation in Differentiating Slowly- From Rapidly Progressive-Precocious Puberty Unknown status NCT01800565 Not Applicable
31 Follow-up of Girls With Premature Thelarche and Precocious Puberty Unknown status NCT01944475
32 Clinical Trial of Experienced Chinese Herbal Formulas on Different Types of Precocious Puberty Unknown status NCT02650141 Not Applicable ziyinxiehuo Granules;zishenqinggan Granules
33 LH Response to GnRH Test in Prepubescent Girls Under 6 Years Unknown status NCT01944488 Not Applicable GnRH agonist
34 Ultrasound Evaluation of Bone Age in Healthy Children Unknown status NCT01980693 Not Applicable
35 Psychosocial Impact of Early Puberty in Girls Aged 6 to 8 Years Completed NCT01679925
36 Purification of Testis-Stimulating Factor in Precocious Puberty Completed NCT00004344 leuprolide;testosterone
37 Follicle-Stimulating Hormone (FSH) and the Onset of Puberty Completed NCT00734279 Early Phase 1 Leuprolide Acetate - Early Puberty Leuprolide Visit;Ganirelix - Early Puberty Ganirelix Visit;Ganirelix - Delayed Puberty Ganirelix Visit;Leuprolide Acetate- Delayed Puberty Leuprolide Visit
38 Study of Gonadotropin-Releasing Hormone Pulse Frequency in Sexual Maturation and in the Menstrual Cycle Completed NCT00004335
39 Exercise in Insulin-Resistant Minority Adolescents Completed NCT00345436
40 Histamine Responsiveness in McCune-Albright Syndrome Completed NCT00318097
41 A Study to Assess the Safety and Efficacy of Leuprorelin in Central Precocious Puberty (CPP) Among Chinese Participants Recruiting NCT02993926 Leuprorelin
42 The Effect of Medical Clown on the Pain and Anxiety Perception During LRH Analog Treatment or GH Provocation Test Recruiting NCT02199587 Not Applicable
43 Association Between Soy Based Formula in Infancy and Puberty Recruiting NCT02908971
44 Screening and Natural History of Patients With Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome Recruiting NCT00001727
45 Inherited Reproductive Disorders Recruiting NCT01500447
46 Ovarian Contribution to Androgen Production in Adolescent Girls Recruiting NCT01421810 Not Applicable Dexamethasone;rhCG
47 The Genetic Investigation of Reproductive Disorders (Including Kallmann Syndrome) Recruiting NCT01601171
48 Effect of a GnRH Injection on Ghrelin Concentrations in Girls With Suspected Premature Puberty Active, not recruiting NCT02431416 Not Applicable Gonadotropin releasing hormone (GnRH);Sodium Chloride
49 Long-term Outcome of GnRH Analogues Treatment of Children With Idiopathic Central Precocious Puberty Enrolling by invitation NCT02790112 Not Applicable
50 Natural History Study of Patients With Excess Androgen Enrolling by invitation NCT00250159

Search NIH Clinical Center for Precocious Puberty

Inferred drug relations via UMLS 73 / NDF-RT 51 :
Sources

Genetic Tests for Precocious Puberty

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Genetic tests related to Precocious Puberty:

# Genetic test Affiliating Genes
1 Precocious Puberty 29
Sources

Anatomical Context for Precocious Puberty

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MalaCards organs/tissues related to Precocious Puberty:

41
Bone, Testes, Pituitary, Brain, Ovary, Pineal, Testis
Sources

Publications for Precocious Puberty

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Articles related to Precocious Puberty:

(show top 50) (show all 964)
# Title Authors Year
1
CENTRAL PRECOCIOUS PUBERTY CAUSED BY A HETEROZYGOUS DELETION IN THE MKRN3 PROMOTER REGION. ( 29763903 )
2018
2
Central precocious puberty in a case of late-diagnosed familial testotoxicosis and long-term treatment monitoring. ( 29858851 )
2018
3
Herbal medicine for idiopathic central precocious puberty: A protocol for a systematic review of controlled trials. ( 29595688 )
2018
4
Gonadotropin-Releasing Hormone (GnRHa) Therapy for Central Precocious Puberty (CPP): Review of Nuances in Assessment of Height, Hormonal Suppression, Psychosocial Issues, and Weight Gain, with Patient Examples. ( 29806750 )
2018
5
A Case of a Girl with Arnold-Chiari Type 1 Malformation with Precocious Puberty. ( 29383213 )
2018
6
Subnormal Growth Velocity And Related Factors During GnRH Analog Therapy For Idiopathic Central Precocious Puberty. ( 29687783 )
2018
7
Investigation of <i>MKRN3</i> mutation in patients with familial central precocious puberty. ( 29537379 )
2018
8
Evaluation of characteristics of the craniofacial complex and dental maturity in girls with central precocious puberty. ( 29708396 )
2018
9
The prevalence of brain abnormalities in boys with central precocious puberty may be overestimated. ( 29614125 )
2018
10
Analysis of the PvuII and XbaI polymorphisms in the estrogen receptor alpha gene in girls with central precocious puberty: a pilot study. ( 29801469 )
2018
11
LHCGR Gene Analysis in Girls with Non-Classic Central Precocious Puberty. ( 29506309 )
2018
12
Review and evaluation of patient-centered psychosocial assessments for children with central precocious puberty or early puberty. ( 29649000 )
2018
13
Prevalence of cranial MRI findings in girls with central precocious puberty: a systematic review and meta-analysis. ( 29902155 )
2018
14
Etiological trends in male central precocious puberty. ( 29969878 )
2018
15
Peripheral Precocious Puberty Caused by Human Chorionic Gonadotropin Producing Pineal Gland Tumor. ( 29629701 )
2018
16
Malocclusion and maxillofacial characteristics of young girls having precocious puberty. ( 29926997 )
2018
17
Predictors of bone maturation, growth rate and adult height in children with central precocious puberty treated with depot leuprolide acetate. ( 29750651 )
2018
18
Longitudinal follow-up to near final height of auxological changes in girls with idiopathic central precocious puberty treated with gonadotropin-releasing hormone analog and grouped by pretreatment body mass index level. ( 29609441 )
2018
19
Visceral fat thickness and its associations with pubertal and metabolic parameters among girls with precocious puberty. ( 29969879 )
2018
20
A case of Riley Ruvalcaba syndrome with a novel PTEN mutation accompanied by diffuse testicular microlithiasis and precocious puberty. ( 29194042 )
2018
21
Presentation of central precocious puberty in two patients with Tay-Sachs disease. ( 29943104 )
2018
22
Triptorelin depot for the treatment of children 2 years and older with central precocious puberty. ( 29957076 )
2018
23
Central precocious puberty in Boston boys: A 10-year single center experience. ( 29949619 )
2018
24
Triptorelin (Triptodur) for central precocious puberty. ( 29294465 )
2018
25
Association between bisphenol a exposure and idiopathic central precocious puberty (ICPP) among school-aged girls in Shanghai, China. ( 29650233 )
2018
26
Adult height in patients with familial male-limited precocious puberty and the role of an aromatase inhibitor in patient management. ( 29654692 )
2018
27
The usefulness of circulating levels of leptin, kisspeptin, and neurokinin B in obese girls with precocious puberty. ( 29303010 )
2018
28
Change in body mass index and insulin resistance after 1-year treatment with gonadotropin-releasing hormone agonists in girls with central precocious puberty. ( 28443256 )
2017
29
A Critical Appraisal of the Effect of Gonadotropin-Releasing Hormon Analog Treatment on Adult Height of Girls with Central Precocious Puberty. ( 29280737 )
2017
30
Phacomatosis pigmentokeratotica and precocious puberty associated with HRAS mutation. ( 28489335 )
2017
31
MKRN3 levels in girls with central precocious puberty and correlation with sexual hormone levels: a pilot study. ( 28299573 )
2017
32
Long-term Outcomes of Patients with Central Precocious Puberty due to Hypothalamic Hamartoma After GnRH Analog Treatment: Anthropometric, Metabolic and Reproductive Aspects. ( 28558376 )
2017
33
Characteristics of traditional Chinese medicine usage in children with precocious puberty: A nationwide population-based study. ( 28499829 )
2017
34
Precocious Puberty or Premature Thelarche: Analysis of a Large Patient Series in a Single Tertiary Center with Special Emphasis on 6- to 8-Year-Old Girls. ( 28878739 )
2017
35
Kisspeptin permits the sexual development of female rats with normal and precocious puberty but is not a trigger for it. ( 29298283 )
2017
36
Central Precocious Puberty and Response to GnRHa Therapy in Children with Cerebral Palsy and Moderate to Severe Motor Impairment: Data from a Longitudinal, Case-Control, Multicentre, Italian Study. ( 28791047 )
2017
37
Association study of LIN28B in girls with precocious puberty. ( 28525351 )
2017
38
Preventive Effect and Safety of a Follicle Stimulating Hormone Inhibitory Formulation Containing a Mixture of<i>Coicis Semen</i>and<i>Artemisia capillaris</i>for Precocious Puberty: A Preliminary Experimental Study Using Female Rats. ( 29348765 )
2017
39
Paternally Inherited DLK1 Deletion Associated With Familial Central Precocious Puberty. ( 28324015 )
2017
40
The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP). ( 28251550 )
2017
41
Treatment outcomes of gonadotropin-releasing hormone agonist in obese girls with central precocious puberty. ( 29301187 )
2017
42
Metabolic Outcomes, Bone Health, and Risk of Polycystic Ovary Syndrome in Girls with Idiopathic Central Precocious Puberty Treated with Gonadotropin-Releasing Hormone Analogues. ( 28391271 )
2017
43
One-Year Follow-Up of Girls with Precocious Puberty and Their Mothers: Do Psychological Assessments Change over Time or with Treatment? ( 28926827 )
2017
44
Corrigendum to: Increased high molecular weight adiponectin, but decreased total adiponectin and kisspeptin, in central precocious puberty compared with aged-matched prepubertal girls. ( 29145926 )
2017
45
Meta-Analysis of Paediatric Patients with Central Precocious Puberty Treated with Intramuscular Triptorelin 11.25 mg 3-Month Prolonged-Release Formulationa8c. ( 28334719 )
2017
46
Effect of gonadotropin-releasing hormone analogue on final adult height among Jordanian children with precocious puberty. ( 29114697 )
2017
47
Higher phthalate concentrations are associated with precocious puberty in normal weight Thai girls. ( 29176028 )
2017
48
Treatment of Girls and Boys with McCune-Albright Syndrome with Precocious Puberty - Update 2017. ( 29292624 )
2017
49
Effects of pomegranate extract in supplementing gonadotropin-releasing hormone therapy on idiopathic central precocious puberty in Chinese girls: a randomized, placebo-controlled, double-blind clinical trial. ( 28091641 )
2017
50
Effect of Antiandrogen, Aromatase Inhibitor, and Gonadotropin-releasing Hormone Analog on Adult Height in Familial Male Precocious Puberty. ( 29144249 )
2017
Sources

Variations for Precocious Puberty

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Sources

Expression for Precocious Puberty

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Search GEO for disease gene expression data for Precocious Puberty.
Sources

Pathways for Precocious Puberty

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Pathways related to Precocious Puberty according to KEGG:

37
# Name Kegg Source Accession
1 Calcium signaling pathway hsa04020
2 Neuroactive ligand-receptor interaction hsa04080
3 GnRH signaling pathway hsa04912

Pathways related to Precocious Puberty according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Peptide ligand-binding receptors 66
Show member pathways
 12.9 GH1 GNAS GNRH1 KISS1 KISS1R LHCGR
2
Steroid hormone biosynthesis 37
Show member pathways
 11.13 CYP19A1 CYP21A2
3
Ovarian Infertility Genes 1
10.76 CYP19A1 LHCGR
4
Ovarian steroidogenesis 37
10.49 CYP19A1 GNAS LHCGR
5
Hormone ligand-binding receptors 66
10.07 GNRH1 LHCGR
Sources

GO Terms for Precocious Puberty

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Biological processes related to Precocious Puberty according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 9.43 KISS1R LHCGR
2 steroid biosynthetic process GO:0006694 9.4 CYP19A1 CYP21A2
3 cognition GO:0050890 9.37 GNAS LHCGR
4 G-protein coupled receptor signaling pathway GO:0007186 9.35 GNAS GNRH1 KISS1 KISS1R LHCGR
5 activation of adenylate cyclase activity GO:0007190 9.32 GNAS LHCGR
6 sterol metabolic process GO:0016125 9.26 CYP19A1 CYP21A2
7 female gonad development GO:0008585 9.16 CYP19A1 LHCGR
8 uterus development GO:0060065 8.62 CYP19A1 LHCGR

Molecular functions related to Precocious Puberty according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hydroxylase activity GO:0008395 8.96 CYP19A1 CYP21A2
2 G-protein coupled peptide receptor activity GO:0008528 8.62 KISS1R LHCGR
Sources

Sources for Precocious Puberty

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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