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MCID: PRC019
MIFTS: 52

Precocious Puberty

Categories: Endocrine diseases, Genetic diseases, Metabolic diseases, Rare diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Precocious Puberty

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MalaCards integrated aliases for Precocious Puberty:

Name: Precocious Puberty 54 38 30 74
Cryptogenic Sexual Precocity 74
Familial Precocious Puberty 54
Idiopathic Sexual Precocity 54
Puberty Precocious 56
Sexual Precocity 54

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases Metabolic diseases
Anatomical: Endocrine diseases Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

KEGG 38 H00937
ICD10 34 E30.1
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Summaries for Precocious Puberty

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NIH Rare Diseases : 54 Precocious puberty is when a person's sexual and physical traits develop and mature earlier than normal. Normal puberty typically begins between ages 10 and 14 for girls, and ages 12 and 16 for boys. The start of puberty depends on various factors such as family history, nutrition and gender. The cause of precocious puberty is not always known. Some cases of precocious puberty are due to conditions that cause changes in the body's release of hormones. Treatment involves medications that can stop the release of sexual hormones.

MalaCards based summary : Precocious Puberty, also known as cryptogenic sexual precocity, is related to precocious puberty, male-limited and idiopathic central precocious puberty. An important gene associated with Precocious Puberty is LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor), and among its related pathways/superpathways are Calcium signaling pathway and Neuroactive ligand-receptor interaction. The drugs Leuprolide and Metformin have been mentioned in the context of this disorder. Affiliated tissues include bone, pituitary and testes, and related phenotypes are adipose tissue and endocrine/exocrine gland

Wikipedia : 77 In medicine, precocious puberty is puberty occurring at an unusually early age. In most cases, the... more...

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Related Diseases for Precocious Puberty

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Diseases in the Precocious Puberty family:

Precocious Puberty, Central, 1 Precocious Puberty, Central, 2
Central Precocious Puberty Secondary Central Precocious Puberty

Diseases related to Precocious Puberty via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 241)
# Related Disease Score Top Affiliating Genes
1 precocious puberty, male-limited 34.3 CYP19A1 LHCGR
2 idiopathic central precocious puberty 33.7 KISS1 KISS1R MKRN3
3 central precocious puberty 33.4 GH1 GNRH1 KISS1 KISS1R MKRN3
4 testotoxicosis 33.0 CYP19A1 GNAS LHCGR
5 mccune-albright syndrome 32.8 CYP19A1 GH1 GNAS
6 hypothalamic hamartomas 32.3 GNRH1 KISS1 KISS1R
7 fibrous dysplasia 30.6 GH1 GNAS
8 hypogonadotropic hypogonadism 30.5 GNRH1 KISS1 KISS1R
9 hyperprolactinemia 30.5 GH1 GNRH1
10 craniopharyngioma 30.5 GH1 GNRH1
11 empty sella syndrome 30.5 GH1 GNRH1
12 prader-willi syndrome 30.4 GH1 GNRH1 MKRN3
13 hypogonadism 30.1 GNRH1 KISS1 KISS1R LHCGR
14 hypogonadotropism 30.1 GNRH1 KISS1 KISS1R
15 adrenal rest tumor 30.0 CYP21A2 GNRH1
16 leydig cell tumor 30.0 CYP19A1 CYP21A2 LHCGR
17 hyperandrogenism 30.0 CYP19A1 CYP21A2 GNRH1
18 adenoma 30.0 CYP21A2 GH1 GNAS LHCGR
19 polycystic ovary syndrome 30.0 CYP19A1 CYP21A2 GNRH1
20 amenorrhea 30.0 GNRH1 LHCGR
21 pseudohermaphroditism 30.0 CYP19A1 LHCGR
22 lipoid congenital adrenal hyperplasia 30.0 CYP19A1 CYP21A2
23 luteoma 29.8 CYP19A1 CYP21A2
24 hypopituitarism 29.8 GH1 GNRH1
25 sex cord-gonadal stromal tumor 29.7 CYP19A1 GNAS
26 adrenocortical carcinoma, hereditary 29.7 CYP19A1 CYP21A2 GNAS
27 conn's syndrome 29.6 CYP21A2 GH1 GNAS
28 infertility 29.6 CYP19A1 GNRH1 LHCGR
29 gonadal disease 28.3 CYP19A1 GH1 GNRH1 KISS1 KISS1R LHCGR
30 familial male-limited precocious puberty 12.8
31 precocious puberty, central, 1 12.8
32 precocious puberty, central, 2 12.7
33 spastic paraplegia with precocious puberty 12.6
34 hypotonia, seizures, and precocious puberty 12.4
35 secondary central precocious puberty 12.4
36 precocious puberty, gonadotropin-dependent 12.3
37 aromatase excess syndrome 11.7
38 ovarian sex cord tumor with annular tubules 11.5
39 carpenter syndrome 1 11.3
40 pallister-hall syndrome 11.2
41 adrenal hyperplasia, congenital, due to steroid 11-beta-hydroxylase deficiency 11.2
42 mental retardation, x-linked 102 11.2
43 pineal gland cancer 11.2
44 8p inverted duplication/deletion syndrome 11.2
45 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 11.2
46 polyembryoma 11.2
47 septo-optic dysplasia spectrum 11.2
48 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.6
49 hypothyroidism 10.6
50 body mass index quantitative trait locus 1 10.6

Graphical network of the top 20 diseases related to Precocious Puberty:



Diseases related to Precocious Puberty
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Symptoms & Phenotypes for Precocious Puberty

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MGI Mouse Phenotypes related to Precocious Puberty:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.77 CYP19A1 GNAS KISS1 KISS1R LHCGR
2 endocrine/exocrine gland MP:0005379 9.73 CYP19A1 GNAS GNRH1 KISS1 KISS1R LHCGR
3 digestive/alimentary MP:0005381 9.72 CYP19A1 GNRH1 KISS1 KISS1R LHCGR
4 integument MP:0010771 9.55 CYP19A1 GNAS GNRH1 KISS1 KISS1R
5 liver/biliary system MP:0005370 9.43 CYP19A1 GNAS GNRH1 KISS1 KISS1R LHCGR
6 renal/urinary system MP:0005367 9.1 CYP19A1 GNAS GNRH1 KISS1 KISS1R LHCGR
Sources

Drugs & Therapeutics for Precocious Puberty

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Drugs for Precocious Puberty (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Leuprolide Approved, Investigational Phase 4,Phase 3,Early Phase 1 53714-56-0 657181 3911
2
Metformin Approved Phase 4 657-24-9 14219 4091
3 Deslorelin Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 57773-65-6
4 Contraceptive Agents Phase 4,Phase 3,Not Applicable
5 Triptorelin Pamoate Phase 4,Phase 3,Not Applicable
6 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
7 Luteolytic Agents Phase 4,Phase 3,Not Applicable
8 Fertility Agents Phase 4,Phase 3,Early Phase 1,Not Applicable
9 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
11 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
12 Prolactin Release-Inhibiting Factors Phase 4,Phase 2
13 Hypoglycemic Agents Phase 4
14 Insulin, Globin Zinc Phase 4
15 insulin Phase 4
16 Pharmaceutical Solutions Phase 3,Phase 2
17
Spironolactone Approved Phase 2 52-01-7, 1952-01-7 5833
18
Testosterone Approved, Experimental, Investigational Phase 2 58-22-0, 481-30-1 6013 10204
19
Testolactone Approved, Investigational Phase 2 968-93-4 13769
20
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
21
Bicalutamide Approved Phase 2 90357-06-5 2375 56069
22
Fulvestrant Approved, Investigational Phase 2 129453-61-8 104741 17756771
23
Calcium Approved, Nutraceutical Phase 1, Phase 2 7440-70-2 271
24 Androgens Phase 2,Phase 1,Not Applicable
25 Natriuretic Agents Phase 2
26 Mineralocorticoid Receptor Antagonists Phase 2
27 Mineralocorticoids Phase 2
28 diuretics Phase 2
29 Diuretics, Potassium Sparing Phase 2
30 Estrogens Phase 2,Phase 1
31 Aromatase Inhibitors Phase 2,Phase 1
32 Estrogen Receptor Antagonists Phase 2,Phase 1
33 Steroid Synthesis Inhibitors Phase 2,Phase 1
34 Estrogen Antagonists Phase 2,Phase 1
35 Androgen Antagonists Phase 2
36 Calcium, Dietary Phase 1, Phase 2
37 Bone Density Conservation Agents Phase 1, Phase 2
38
Oxandrolone Approved, Investigational Phase 1 53-39-4 5878
39
Letrozole Approved, Investigational Phase 1 112809-51-5 3902
40 Anabolic Agents Phase 1
41
Ganirelix Approved Early Phase 1 123246-29-7, 124904-93-4 25081094
42
Zinc Approved, Investigational 7440-66-6 32051
43
Histamine Approved, Investigational 51-45-6 774
44
Dexamethasone Approved, Investigational, Vet_approved Not Applicable 50-02-2 5743
45
Dexamethasone acetate Approved, Investigational, Vet_approved Not Applicable 1177-87-3
46
Racepinephrine Approved 329-65-7 838
47
Epinephrine Approved, Vet_approved 51-43-4 5816
48
Menotropins Approved Not Applicable 9002-68-0, 61489-71-2 5360545
49 Liver Extracts Not Applicable
50 Follicle Stimulating Hormone Early Phase 1

Interventional clinical trials:

(show top 50) (show all 54)
# Name Status NCT ID Phase Drugs
1 Analysis of Genetic and Environmental Parameters Influencing Growth Rate of Precocious Puberty Children Unknown status NCT00438217 Phase 4 Triptorelin (GnRH agonists);Leuprolide (GnRH agonists)
2 Analysis of Body Mass Index in Central Precocious Puberty Patients Treated With Leuprolide Acetate Unknown status NCT02974270 Phase 4 Leuprolide
3 Comparative Validation of the Triptorelin Test for the Diagnosis of CPP in Girls Unknown status NCT01278290 Phase 4 Triptorelin acetate and Gonadorelin acetate;Gonadorelin acetate and Triptorelin acetate
4 Study of Comprehensive Diagnosis and Treatment for Children Precocious Puberty Completed NCT02920515 Phase 4 Triptorlin or Leuprorelin;Zhibo dihuang pills;Dabu ying pills
5 The Clinical Trial to Evaluate the Efficacy and Safety of Luphere Depot Inj. 3.75mg(Leuprolide Acetate 3.75mg) in Patients With Precocious Puberty Completed NCT01634321 Phase 4 Luphere depot 3.75mg(Leuprolide acetate 3.75mg)
6 A Study to Assess the Safety and Efficacy of Leuprorelin in Central Precocious Puberty in Chinese Patients Completed NCT02427958 Phase 4 Leuprorelin
7 Understanding Experimentally Induced Hot Flushes Completed NCT00455689 Phase 4 Leuprolide acetate
8 The Health Influences of Puberty (HIP) Study Completed NCT01775813 Phase 4 Metformin
9 Leuprorelin Acetate DPS (Leuplin DPS) Treatment Quarterly in Patients With Central Precocious Puberty Recruiting NCT03316482 Phase 4 Leuplin DPS 11.25mg
10 A 4 Year Combination Therapy of Growth Hormone and (GnRH) Agonist in Children With a Short Predicted Height Active, not recruiting NCT00840944 Phase 4 somatropin;triptorelin
11 Pharmacokinetic Study of Leuprolide Acetate Injectable Suspension in the Treatment of Central Precocious Puberty Completed NCT02452931 Phase 3 Leuprolide Acetate 45 mg
12 Efficacy, Safety, and Pharmacokinetics (PK) of Triptorelin 6-month Formulation in Patients With Central Precocious Puberty Completed NCT01467882 Phase 3 Triptorelin
13 Histrelin Subcutaneous Implant in Children With Central Precocious Puberty Completed NCT00779103 Phase 3 Histrelin Subcutaneous Implant
14 Effects of Triptorelin Pamoate in Children With Precocious Puberty - Follow up Study Completed NCT00909844 Phase 3 Triptorelin (I.N.N.)
15 Efficacy and Safety Study of Pamoate of Triptorelin in Children With Precocious Puberty Completed NCT00564850 Phase 3 Triptorelin pamoate 11.25mg (Decapeptyl® SR)
16 Safety Extension Study Of Leuprolide Acetate (Lupron Depot) In The Treatment Of Central Precocious Puberty Completed NCT00667446 Phase 3 Leuprolide Acetate 3 Month Depot
17 Study of Lupron Depot In The Treatment of Central Precocious Puberty Completed NCT00660010 Phase 3 Lupron (leuprolide acetate)
18 A Study of Leuprolide 11.25 mg and 30 mg Administered Every 3 Months to Treat Central Precocious Puberty Completed NCT00635817 Phase 3 Leuprolide acetate 11.25 mg;Leuprolide acetate 30 mg
19 A Study to Evaluate Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of Leuprolide Acetate 45mg 6-Month Formulation in Children With Central Precocious Puberty (CPP) Recruiting NCT03695237 Phase 3 Leuprolide Acetate (LA)
20 Severe Decrease of Growth Velocity in Children With Anorexia Nervosa.Therapeutic Trial of Growth Hormone Active, not recruiting NCT01626833 Phase 2, Phase 3 SOMATROPINE* : Norditropine® simplexx®
21 Treatment of Boys With Precocious Puberty Completed NCT00001202 Phase 2 Spironolactone;Testolactone;Deslorelin
22 Testolactone for the Treatment of Girls With LHRH Resistant Precocious Puberty Completed NCT00001181 Phase 2 Testolactone
23 Pediatrics Testotoxicosis Study [Bicalutamide Anastrozole Treatment for Testotoxicosis] Completed NCT00094328 Phase 2 Bicalutamide;Anastrozole
24 Encouraging Calcium Absorption and Bone Formation During Early Puberty Completed NCT00022867 Phase 1, Phase 2 Nondigestible oligosaccharide (NDO)
25 Arimidex in McCune Albright Syndrome Completed NCT00055302 Phase 2 Arimidex 1 mg
26 Study of Luteinizing Hormone-Releasing Hormone Analog (LHRHa) in Pubertal Patients With Extreme Short Stature Completed NCT00001190 Phase 2 Deslorelin
27 Faslodex in McCune Albright Syndrome Active, not recruiting NCT00278915 Phase 2 Fulvestrant
28 Pilot Study of the Safety and Efficacy of Oxandrolone in the Prevention and Treatment of Malnutrition in Infants Unknown status NCT01048632 Phase 1 Oxandrolone
29 Effects of Letrozole on Precocious Puberty Due to McCune Albright Syndrome Completed NCT00006174 Phase 1 Letrozole
30 First-Voided Urinary LH vs. GnRH-stimulation in Differentiating Slowly- From Rapidly Progressive-Precocious Puberty Unknown status NCT01800565 Not Applicable
31 Follow-up of Girls With Premature Thelarche and Precocious Puberty Unknown status NCT01944475
32 Clinical Trial of Experienced Chinese Herbal Formulas on Different Types of Precocious Puberty Unknown status NCT02650141 Not Applicable ziyinxiehuo Granules;zishenqinggan Granules
33 Long-term Outcome of GnRH Analogues Treatment of Children With Idiopathic Central Precocious Puberty Unknown status NCT02790112 Not Applicable
34 LH Response to GnRH Test in Prepubescent Girls Under 6 Years Unknown status NCT01944488 Not Applicable GnRH agonist
35 Ultrasound Evaluation of Bone Age in Healthy Children Unknown status NCT01980693 Not Applicable
36 Psychosocial Impact of Early Puberty in Girls Aged 6 to 8 Years Completed NCT01679925
37 Purification of Testis-Stimulating Factor in Precocious Puberty Completed NCT00004344 leuprolide;testosterone
38 Effect of a GnRH Injection on Ghrelin Concentrations in Girls With Suspected Premature Puberty Completed NCT02431416 Not Applicable Gonadotropin releasing hormone (GnRH);Sodium Chloride
39 A Study to Assess the Safety and Efficacy of Leuprorelin in Central Precocious Puberty (CPP) Among Chinese Participants Completed NCT02993926 Leuprorelin
40 The Effect of Medical Clown on the Pain and Anxiety Perception During LRH Analog Treatment or GH Provocation Test Completed NCT02199587 Not Applicable
41 Follicle-Stimulating Hormone (FSH) and the Onset of Puberty Completed NCT00734279 Early Phase 1 Leuprolide Acetate - Early Puberty Leuprolide Visit;Ganirelix - Early Puberty Ganirelix Visit;Ganirelix - Delayed Puberty Ganirelix Visit;Leuprolide Acetate- Delayed Puberty Leuprolide Visit
42 Study of Gonadotropin-Releasing Hormone Pulse Frequency in Sexual Maturation and in the Menstrual Cycle Completed NCT00004335
43 Exercise in Insulin-Resistant Minority Adolescents Completed NCT00345436
44 Histamine Responsiveness in McCune-Albright Syndrome Completed NCT00318097
45 The Effect of Decaffeinated Green Tea Polyphenol Intake on the Risk of Precocious Puberty Among Obese Girls Recruiting NCT03628937 Not Applicable
46 Association Between Soy Based Formula in Infancy and Puberty Recruiting NCT02908971
47 Screening and Natural History of Patients With Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome Recruiting NCT00001727
48 Inherited Reproductive Disorders Recruiting NCT01500447
49 Ovarian Contribution to Androgen Production in Adolescent Girls Recruiting NCT01421810 Not Applicable Dexamethasone;rhCG
50 The Genetic Investigation of Reproductive Disorders (Including Kallmann Syndrome) Recruiting NCT01601171

Search NIH Clinical Center for Precocious Puberty

Inferred drug relations via UMLS 74 / NDF-RT 52 :
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Genetic Tests for Precocious Puberty

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Genetic tests related to Precocious Puberty:

# Genetic test Affiliating Genes
1 Precocious Puberty 30
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Anatomical Context for Precocious Puberty

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MalaCards organs/tissues related to Precocious Puberty:

42
Bone, Pituitary, Testes, Brain, Ovary, Pineal, Testis
Sources

Publications for Precocious Puberty

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Articles related to Precocious Puberty:

(show top 50) (show all 1571)
# Title Authors Year
1
Pituitary deficiency and precocious puberty after childhood severe traumatic brain injury: a long-term follow-up prospective study. ( 30884465 )
2019
2
Novel DNA variation of GPR54 gene in familial central precocious puberty. ( 30635063 )
2019
3
(Epi)genetic defects of MKRN3 are rare in Asian patients with central precocious puberty. ( 30675365 )
2019
4
One-year treatment with gonadotropin-releasing hormone analogues does not affect body mass index, insulin sensitivity or lipid profile in girls with central precocious puberty. ( 30699070 )
2019
5
Central precocious puberty, functional and tumor-related. ( 30733078 )
2019
6
Development of Prediction Models Using Machine Learning Algorithms for Girls with Suspected Central Precocious Puberty: Retrospective Study. ( 30747712 )
2019
7
Update on central precocious puberty: from etiologies to outcomes. ( 30763521 )
2019
8
Central Precocious Puberty as Presenting Sign of Non-Classical Congenital Adrenal Hyperplasia - Clinical Characteristics. ( 30779848 )
2019
9
Pelvic Ultrasound in Diagnosing and Evaluating the Efficacy of Gonadotropin-Releasing Hormone Agonist Therapy in Girls With Idiopathic Central Precocious Puberty. ( 30804790 )
2019
10
Serum Makorin ring finger protein 3 values for predicting Central precocious puberty in girls. ( 30806524 )
2019
11
Central precocious puberty in girls: Diagnostic study and auxological response to triptorelin treatment. ( 30808564 )
2019
12
Incidence and Prevalence of Central Precocious Puberty in Korea: An Epidemiologic Study Based on a National Database. ( 30857777 )
2019
13
Precocious pseudopuberty due to virilising adrenocortical carcinoma progressing to central precocious puberty after surgery. ( 30862670 )
2019
14
Hepatoblastoma with Precocious Puberty. ( 30686892 )
2019
15
Co-occurrence of genomic imbalances on Xp22.1 in the SHOX region and 15q25.2 in a girl with short stature, precocious puberty, urogenital malformations and bone anomalies. ( 30626445 )
2019
16
The Gonadotropin-Releasing Hormone Analogue Therapy May Not Impact Final Height in Precocious Puberty of Girls With Onset of Puberty Aged 6 - 8 Years. ( 30701006 )
2019
17
Effect of a social support program for mothers of children with precocious puberty: A preliminary quasi-experimental study. ( 30770158 )
2019
18
Idiopathic gonadotropin-independent precocious puberty - is regular surveillance required? ( 30849047 )
2019
19
MiR-664-2 impacts pubertal development in a precocious-puberty rat model through targeting the NMDA receptor-1. ( 30916745 )
2019
20
Hydroxymethylation of protein-encoding genes in the testes involved in precocious puberty of Eriocheir sinensis. ( 30315924 )
2019
21
CENTRAL PRECOCIOUS PUBERTY CAUSED BY A HETEROZYGOUS DELETION IN THE MKRN3 PROMOTER REGION. ( 29763903 )
2018
22
Central precocious puberty in a case of late-diagnosed familial testotoxicosis and long-term treatment monitoring. ( 29858851 )
2018
23
Herbal medicine for idiopathic central precocious puberty: A protocol for a systematic review of controlled trials. ( 29595688 )
2018
24
Gonadotropin-Releasing Hormone (GnRHa) Therapy for Central Precocious Puberty (CPP): Review of Nuances in Assessment of Height, Hormonal Suppression, Psychosocial Issues, and Weight Gain, with Patient Examples. ( 29806750 )
2018
25
A Case of a Girl with Arnold-Chiari Type 1 Malformation with Precocious Puberty. ( 29383213 )
2018
26
Subnormal Growth Velocity And Related Factors During GnRH Analog Therapy For Idiopathic Central Precocious Puberty. ( 29687783 )
2018
27
Investigation of <i>MKRN3</i> mutation in patients with familial central precocious puberty. ( 29537379 )
2018
28
Evaluation of characteristics of the craniofacial complex and dental maturity in girls with central precocious puberty. ( 29708396 )
2018
29
The prevalence of brain abnormalities in boys with central precocious puberty may be overestimated. ( 29614125 )
2018
30
Analysis of the PvuII and XbaI polymorphisms in the estrogen receptor alpha gene in girls with central precocious puberty: a pilot study. ( 29801469 )
2018
31
LHCGR Gene Analysis in Girls with Non-Classic Central Precocious Puberty. ( 29506309 )
2018
32
Review and evaluation of patient-centered psychosocial assessments for children with central precocious puberty or early puberty. ( 29649000 )
2018
33
Prevalence of cranial MRI findings in girls with central precocious puberty: a systematic review and meta-analysis. ( 29902155 )
2018
34
Etiological trends in male central precocious puberty. ( 29969878 )
2018
35
Peripheral Precocious Puberty Caused by Human Chorionic Gonadotropin Producing Pineal Gland Tumor. ( 29629701 )
2018
36
Malocclusion and maxillofacial characteristics of young girls having precocious puberty. ( 29926997 )
2018
37
Predictors of bone maturation, growth rate and adult height in children with central precocious puberty treated with depot leuprolide acetate. ( 29750651 )
2018
38
Longitudinal follow-up to near final height of auxological changes in girls with idiopathic central precocious puberty treated with gonadotropin-releasing hormone analog and grouped by pretreatment body mass index level. ( 29609441 )
2018
39
Visceral fat thickness and its associations with pubertal and metabolic parameters among girls with precocious puberty. ( 29969879 )
2018
40
A case of Riley Ruvalcaba syndrome with a novel PTEN mutation accompanied by diffuse testicular microlithiasis and precocious puberty. ( 29194042 )
2018
41
Presentation of central precocious puberty in two patients with Tay-Sachs disease. ( 29943104 )
2018
42
Triptorelin depot for the treatment of children 2 years and older with central precocious puberty. ( 29957076 )
2018
43
Central precocious puberty in Boston boys: A 10-year single center experience. ( 29949619 )
2018
44
Triptorelin (Triptodur) for central precocious puberty. ( 29294465 )
2018
45
Association between bisphenol a exposure and idiopathic central precocious puberty (ICPP) among school-aged girls in Shanghai, China. ( 29650233 )
2018
46
Adult height in patients with familial male-limited precocious puberty and the role of an aromatase inhibitor in patient management. ( 29654692 )
2018
47
The usefulness of circulating levels of leptin, kisspeptin, and neurokinin B in obese girls with precocious puberty. ( 29303010 )
2018
48
Anxiety, Self-esteem and Body Image in Girls with Precocious Puberty. ( 30286845 )
2018
49
Comparison of two bone markers with growth evolution in 74 girls with central precocious puberty. ( 29986677 )
2018
50
Serum levels of LH, IGF-1 and leptin in girls with idiopathic central precocious puberty (ICPP) and the correlations with the development of ICPP. ( 30037185 )
2018
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Variations for Precocious Puberty

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Expression for Precocious Puberty

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Search GEO for disease gene expression data for Precocious Puberty.
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Pathways for Precocious Puberty

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Pathways related to Precocious Puberty according to KEGG:

38
# Name Kegg Source Accession
1 Calcium signaling pathway hsa04020
2 Neuroactive ligand-receptor interaction hsa04080
3 GnRH signaling pathway hsa04912

Pathways related to Precocious Puberty according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Peptide ligand-binding receptors 67
Show member pathways
 12.91 GH1 GNAS GNRH1 KISS1 KISS1R LHCGR
2
Steroid hormone biosynthesis 38
Show member pathways
 11.19 CYP19A1 CYP21A2
3
G-protein signaling_RhoA regulation pathway 23
11.19 GH1 GNAS GNRH1
4
Ovarian Infertility Genes 1
10.76 CYP19A1 LHCGR
5
Ovarian steroidogenesis 38
10.49 CYP19A1 GNAS LHCGR
6
Hormone ligand-binding receptors 67
10.07 GNRH1 LHCGR
Sources

GO Terms for Precocious Puberty

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Biological processes related to Precocious Puberty according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid biosynthetic process GO:0006694 9.32 CYP19A1 CYP21A2
2 cognition GO:0050890 9.26 GNAS LHCGR
3 activation of adenylate cyclase activity GO:0007190 9.16 GNAS LHCGR
4 G protein-coupled receptor signaling pathway GO:0007186 9.02 GNAS GNRH1 KISS1 KISS1R LHCGR
5 sterol metabolic process GO:0016125 8.96 CYP19A1 CYP21A2

Molecular functions related to Precocious Puberty according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled peptide receptor activity GO:0008528 8.96 KISS1R LHCGR
2 steroid hydroxylase activity GO:0008395 8.62 CYP19A1 CYP21A2
Sources

Sources for Precocious Puberty

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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