MCID: PRC004
MIFTS: 21

Precursor B Lymphoblastic Lymphoma/leukemia

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Precursor B Lymphoblastic Lymphoma/leukemia

MalaCards integrated aliases for Precursor B Lymphoblastic Lymphoma/leukemia:

Name: Precursor B Lymphoblastic Lymphoma/leukemia 38 12 15
B Lymphoblastic Leukemia/lymphoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7061
NCIt 50 C8936
UMLS 73 C0862030

Summaries for Precursor B Lymphoblastic Lymphoma/leukemia

MalaCards based summary : Precursor B Lymphoblastic Lymphoma/leukemia, also known as b lymphoblastic leukemia/lymphoma, is related to precursor lymphoblastic lymphoma/leukemia. An important gene associated with Precursor B Lymphoblastic Lymphoma/leukemia is PTPRJ (Protein Tyrosine Phosphatase, Receptor Type J), and among its related pathways/superpathways is PAK Pathway. The drugs Fludarabine and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include b lymphoblasts, b cells and testes.

Related Diseases for Precursor B Lymphoblastic Lymphoma/leukemia

Diseases in the Precursor Lymphoblastic Lymphoma/leukemia family:

Precursor B Lymphoblastic Lymphoma/leukemia Precursor T-Lymphoblastic Lymphoma/leukemia

Diseases related to Precursor B Lymphoblastic Lymphoma/leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 precursor lymphoblastic lymphoma/leukemia 9.7 CD27 PTPRJ

Symptoms & Phenotypes for Precursor B Lymphoblastic Lymphoma/leukemia

Drugs & Therapeutics for Precursor B Lymphoblastic Lymphoma/leukemia

Drugs for Precursor B Lymphoblastic Lymphoma/leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fludarabine Approved Phase 2 75607-67-9, 21679-14-1 30751
2
Cyclophosphamide Approved, Investigational Phase 2 6055-19-2, 50-18-0 2907

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 MB-CART19.1 in Patients With R/R ALL Not yet recruiting NCT03321123 Phase 2 MB-CART19.1

Search NIH Clinical Center for Precursor B Lymphoblastic Lymphoma/leukemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Stem-cell-based therapeutic approaches for Precursor B Lymphoblastic Lymphoma/leukemia:
Blood stem cell transplantation for hematological diseases
Embryonic/Adult Cultured Cells Related to Precursor B Lymphoblastic Lymphoma/leukemia:
Peripheral blood-derived hematopoietic stem cells (family)

Genetic Tests for Precursor B Lymphoblastic Lymphoma/leukemia

Anatomical Context for Precursor B Lymphoblastic Lymphoma/leukemia

MalaCards organs/tissues related to Precursor B Lymphoblastic Lymphoma/leukemia:

41
B Lymphoblasts, B Cells, Testes

Publications for Precursor B Lymphoblastic Lymphoma/leukemia

Articles related to Precursor B Lymphoblastic Lymphoma/leukemia:

(show all 16)
# Title Authors Year
1
Lymphomatoid Granulomatosis in a 14-Year-Old Boy with Trisomy 21 and History of B-Lymphoblastic Leukemia/Lymphoma. ( 29336635 )
2018
2
B Lymphoblastic Leukemia/Lymphoma With Burkitt-like Morphology and IGH/MYC Rearrangement: Report of 3 Cases in Adult Patients. ( 29112016 )
2018
3
Laboratory testing in BCR-ABL1-like (Philadelphia-like) B-lymphoblastic leukemia/lymphoma. ( 29696694 )
2018
4
A novel flow cytometric assay for detection of residual disease in patients with B-lymphoblastic leukemia/lymphoma post anti-CD19 therapy. ( 27598971 )
2018
5
Chronic Myelogenous Leukemia Presenting as a Secondary Malignancy After BCR-ABL1-negative B-lymphoblastic Leukemia/Lymphoma in a Pediatric Patient. ( 28276292 )
2017
6
B lymphoblastic leukemia/lymphoma: new insights into genetics, molecular aberrations, subclassification and targeted therapy. ( 29029550 )
2017
7
Immunophenotypic and cytogenetic findings of B-lymphoblastic leukemia/lymphoma associated with combined IGH/BCL2 and MYC rearrangement. ( 26517296 )
2017
8
CD25 Expression in B Lymphoblastic Leukemia/Lymphoma Predicts t(9;22)(q34;q11)/Philadelphia Chromosome Translocation (Ph) and Is Associated With Residual Disease in Ph-Negative Patients. ( 28430957 )
2016
9
B-lymphoblastic leukemia/lymphoma: overexpression of nuclear DNA repair protein PARP-1 correlates with antiapoptotic protein Bcl-2 and complex chromosomal abnormalities. ( 24856976 )
2014
10
Extramedullary B lymphoblastic leukemia/lymphoma (B-ALL/B-LBL): a diagnostic challenge. ( 24589157 )
2014
11
B-lymphoblastic leukemia/lymphoma associated with t(8;13)(p11;q12)/ ZMYM2 (ZNF198)-FGFR1 : rare case and review of the literature. ( 23594707 )
2013
12
B lymphoblastic leukemia/lymphoma presenting as seventh cranial nerve palsy. ( 30107017 )
2013
13
Concurrent t(4;11) and t(1:19) in a Pediatric Patient with B-Lymphoblastic Leukemia/Lymphoma (B-ALL): A Case Report and Review of the Literature. ( 26030419 )
2013
14
De novo B lymphoblastic leukemia/lymphoma in an adult with t(14;18)(q32;q21) and c-MYC gene rearrangement involving 10p13. ( 21718139 )
2011
15
Stability of leukemia-associated immunophenotypes in precursor B-lymphoblastic leukemia/lymphoma: a single institution experience. ( 17145625 )
2007
16
Is B-lineage acute lymphoblastic leukemia with a mature phenotype and l1 morphology a precursor B-lymphoblastic leukemia/lymphoma or Burkitt leukemia/lymphoma? ( 14521459 )
2003

Variations for Precursor B Lymphoblastic Lymphoma/leukemia

Expression for Precursor B Lymphoblastic Lymphoma/leukemia

Search GEO for disease gene expression data for Precursor B Lymphoblastic Lymphoma/leukemia.

Pathways for Precursor B Lymphoblastic Lymphoma/leukemia

Pathways related to Precursor B Lymphoblastic Lymphoma/leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.69 CD27 PTPRJ

GO Terms for Precursor B Lymphoblastic Lymphoma/leukemia

Cellular components related to Precursor B Lymphoblastic Lymphoma/leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 8.96 CD27 PTPRJ
2 cell surface GO:0009986 8.62 CD27 PTPRJ

Sources for Precursor B Lymphoblastic Lymphoma/leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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